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Conserved domains on  [gi|2217288863|ref|XP_047284740|]
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photoreceptor ankyrin repeat protein isoform X4 [Homo sapiens]

Protein Classification

ankyrin repeat domain-containing protein( domain architecture ID 11429852)

ankyrin repeat domain-containing protein; ANK proteins mediate specific protein-protein interactions without necessarily recognizing specific primary sequences which allows for one ankyrin repeat domain to recognize and bind to a variety of intracellular substrates and may be involved in a wide array of functions

Gene Ontology:  GO:0005515
PubMed:  17176038
SCOP:  4000366

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
107-259 3.40e-32

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 124.30  E-value: 3.40e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217288863 107 ALYWACVHNDPTQLQAILDGGVSPEeatQVDSNGRTGLMVACYHGFQSVVALLshcpfL----DVNQQDKGGDTALMLAA 182
Cdd:COG0666    90 LLHAAARNGDLEIVKLLLEAGADVN---ARDKDGETPLHLAAYNGNLEIVKLL-----LeagaDVNAQDNDGNTPLHLAA 161

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2217288863 183 QAGHVPLVSLLLNYyvGLDLERRDQRGLTALMKAAMRNRCECVATLLMAGADLTAVDPvRGKTALEWAVLTDSFDTV 259
Cdd:COG0666   162 ANGNLEIVKLLLEA--GADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDN-DGKTALDLAAENGNLEIV 235
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
107-259 3.40e-32

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 124.30  E-value: 3.40e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217288863 107 ALYWACVHNDPTQLQAILDGGVSPEeatQVDSNGRTGLMVACYHGFQSVVALLshcpfL----DVNQQDKGGDTALMLAA 182
Cdd:COG0666    90 LLHAAARNGDLEIVKLLLEAGADVN---ARDKDGETPLHLAAYNGNLEIVKLL-----LeagaDVNAQDNDGNTPLHLAA 161

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2217288863 183 QAGHVPLVSLLLNYyvGLDLERRDQRGLTALMKAAMRNRCECVATLLMAGADLTAVDPvRGKTALEWAVLTDSFDTV 259
Cdd:COG0666   162 ANGNLEIVKLLLEA--GADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDN-DGKTALDLAAENGNLEIV 235
Ank_2 pfam12796
Ankyrin repeats (3 copies);
144-239 2.26e-20

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 85.55  E-value: 2.26e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217288863 144 LMVACYHGFQSVVALLSHCPFlDVNQQDKGGDTALMLAAQAGHVPLVSLLLNYyvgLDLERRDQrGLTALMKAAMRNRCE 223
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGA-DANLQDKNGRTALHLAAKNGHLEIVKLLLEH---ADVNLKDN-GRTALHYAARSGHLE 75

                          90
                  ....*....|....*.
gi 2217288863 224 CVATLLMAGADLTAVD 239
Cdd:pfam12796  76 IVKLLLEKGADINVKD 91
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 120-259 3.72e-06

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 49.48  E-value: 3.72e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217288863 120 LQAILDGGVSPEEAtqvDSNGRTGLMVACYHGFQS-VVALLSH-CpflDVNQQDKGGDTALMLAAQAGHVPLVSLLLNY- 196
Cdd:PLN03192  541 LEELLKAKLDPDIG---DSKGRTPLHIAASKGYEDcVLVLLKHaC---NVHIRDANGNTALWNAISAKHHKIFRILYHFa 614

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2217288863 197 -----YVGLDLerrdqrgltaLMKAAMRNRCECVATLLMAGADLTAVDPvRGKTALEWAVLTDSFDTV 259
Cdd:PLN03192  615 sisdpHAAGDL----------LCTAAKRNDLTAMKELLKQGLNVDSEDH-QGATALQVAMAEDHVDMV 671
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 169-268 6.24e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 42.31  E-value: 6.24e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217288863 169 QQDKGGDTALMLAAQAGHVPLVSLLLNYYvGLDLERRDQRGLTALMKAAMRNRCECVATLLMAGADLTAV----DPVRGK 244
Cdd:cd22192    12 QQKRISESPLLLAAKENDVQAIKKLLKCP-SCDLFQRGALGETALHVAALYDNLEAAVVLMEAAPELVNEpmtsDLYQGE 90

                          90       100
                  ....*....|....*....|....
gi 2217288863 245 TALEWAVLTDSFDTVwriRQLLRR 268
Cdd:cd22192    91 TALHIAVVNQNLNLV---RELIAR 111
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
107-259 3.40e-32

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 124.30  E-value: 3.40e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217288863 107 ALYWACVHNDPTQLQAILDGGVSPEeatQVDSNGRTGLMVACYHGFQSVVALLshcpfL----DVNQQDKGGDTALMLAA 182
Cdd:COG0666    90 LLHAAARNGDLEIVKLLLEAGADVN---ARDKDGETPLHLAAYNGNLEIVKLL-----LeagaDVNAQDNDGNTPLHLAA 161

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2217288863 183 QAGHVPLVSLLLNYyvGLDLERRDQRGLTALMKAAMRNRCECVATLLMAGADLTAVDPvRGKTALEWAVLTDSFDTV 259
Cdd:COG0666   162 ANGNLEIVKLLLEA--GADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDN-DGKTALDLAAENGNLEIV 235
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
107-268 3.44e-24

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 101.95  E-value: 3.44e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217288863 107 ALYWACVHNDPTQLQAILDGGVSPEeatQVDSNGRTGLMVACYHGFQSVV-ALLSHCPflDVNQQDKGGDTALMLAAQAG 185
Cdd:COG0666   123 PLHLAAYNGNLEIVKLLLEAGADVN---AQDNDGNTPLHLAAANGNLEIVkLLLEAGA--DVNARDNDGETPLHLAAENG 197

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217288863 186 HVPLVSLLLNYyvGLDLERRDQRGLTALMKAAMRNRCECVATLLMAGADLTAVDPvRGKTALEWAVLTDSFDTVWRIRQL 265
Cdd:COG0666   198 HLEIVKLLLEA--GADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDK-DGLTALLLAAAAGAALIVKLLLLA 274


                  ...
gi 2217288863 266 LRR 268
Cdd:COG0666   275 LLL 277
Ank_2 pfam12796
Ankyrin repeats (3 copies);
144-239 2.26e-20

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 85.55  E-value: 2.26e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217288863 144 LMVACYHGFQSVVALLSHCPFlDVNQQDKGGDTALMLAAQAGHVPLVSLLLNYyvgLDLERRDQrGLTALMKAAMRNRCE 223
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGA-DANLQDKNGRTALHLAAKNGHLEIVKLLLEH---ADVNLKDN-GRTALHYAARSGHLE 75

                          90
                  ....*....|....*.
gi 2217288863 224 CVATLLMAGADLTAVD 239
Cdd:pfam12796  76 IVKLLLEKGADINVKD 91
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
137-268 2.07e-18

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 85.39  E-value: 2.07e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217288863 137 DSNGRTGLMVACYHGFQSVVALLSHcPFLDVNQQDKGGDTALMLAAQAGHVPLVSLLLNYyvGLDLERRDQRGLTALMKA 216
Cdd:COG0666    51 DALGALLLLAAALAGDLLVALLLLA-AGADINAKDDGGNTLLHAAARNGDLEIVKLLLEA--GADVNARDKDGETPLHLA 127

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2217288863 217 AMRNRCECVATLLMAGADLTAVDPvRGKTALEWAVLTDSFDTVwriRQLLRR 268
Cdd:COG0666   128 AYNGNLEIVKLLLEAGADVNAQDN-DGNTPLHLAAANGNLEIV---KLLLEA 175
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
107-239 4.39e-15

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 75.76  E-value: 4.39e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217288863 107 ALYWACVHNDPTQLQAILDGGVSPEeatQVDSNGRTGLMVACYHGFQSVV-ALLSHCPflDVNQQDKGGDTALMLAAQAG 185
Cdd:COG0666   156 PLHLAAANGNLEIVKLLLEAGADVN---ARDNDGETPLHLAAENGHLEIVkLLLEAGA--DVNAKDNDGKTALDLAAENG 230

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2217288863 186 HVPLVSLLLNYyvGLDLERRDQRGLTALMKAAMRNRCECVATLLMAGADLTAVD 239
Cdd:COG0666   231 NLEIVKLLLEA--GADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAAL 282
Ank_2 pfam12796
Ankyrin repeats (3 copies);
108-206 4.95e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 70.53  E-value: 4.95e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217288863 108 LYWACVHNDPTQLQAILDGGVspeEATQVDSNGRTGLMVACYHGFQSVVALLshCPFLDVNQQDKgGDTALMLAAQAGHV 187
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGA---DANLQDKNGRTALHLAAKNGHLEIVKLL--LEHADVNLKDN-GRTALHYAARSGHL 74

                          90
                  ....*....|....*....
gi 2217288863 188 PLVSLLLNYyvGLDLERRD 206
Cdd:pfam12796  75 EIVKLLLEK--GADINVKD 91
Ank_2 pfam12796
Ankyrin repeats (3 copies);
178-259 3.22e-14

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 68.22  E-value: 3.22e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217288863 178 LMLAAQAGHVPLVSLLLNYyvGLDLERRDQRGLTALMKAAMRNRCECVaTLLMAGADLTAVDpvRGKTALEWAVLTDSFD 257
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLEN--GADANLQDKNGRTALHLAAKNGHLEIV-KLLLEHADVNLKD--NGRTALHYAARSGHLE 75


                  ..
gi 2217288863 258 TV 259
Cdd:pfam12796  76 IV 77
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
155-268 1.99e-09

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 58.43  E-value: 1.99e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217288863 155 VVALLSHCPFLDVNQQDKGGDTALMLAAQAGHVPLVSLLLNYyvGLDLERRDQRGLTALMKAAMRNRCECVATLLMAGAD 234
Cdd:COG0666    35 LLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAA--GADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGAD 112

                          90       100       110
                  ....*....|....*....|....*....|....
gi 2217288863 235 LTAVDPvRGKTALEWAVLTDSFDTVwriRQLLRR 268
Cdd:COG0666   113 VNARDK-DGETPLHLAAYNGNLEIV---KLLLEA 142
Ank_5 pfam13857
Ankyrin repeats (many copies);
158-213 7.77e-07

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 45.80  E-value: 7.77e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2217288863 158 LLSHCPfLDVNQQDKGGDTALMLAAQAGHVPLVSLLLNYyvGLDLERRDQRGLTAL 213
Cdd:pfam13857   1 LLEHGP-IDLNRLDGEGYTPLHVAAKYGALEIVRVLLAY--GVDLNLKDEEGLTAL 53
Ank_4 pfam13637
Ankyrin repeats (many copies);
174-229 8.17e-07

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 45.73  E-value: 8.17e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2217288863 174 GDTALMLAAQAGHVPLVSLLLNYyvGLDLERRDQRGLTALMKAAMRNRCECVATLL 229
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEK--GADINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_4 pfam13637
Ankyrin repeats (many copies);
140-194 1.44e-06

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 44.96  E-value: 1.44e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2217288863 140 GRTGLMVACYHGFQSVVALLsHCPFLDVNQQDKGGDTALMLAAQAGHVPLVSLLL 194
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLL-LEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_5 pfam13857
Ankyrin repeats (many copies);
193-250 2.84e-06

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 44.26  E-value: 2.84e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2217288863 193 LLNYYvGLDLERRDQRGLTALMKAAMRNRCECVATLLMAGADLTAVDPvRGKTALEWA 250
Cdd:pfam13857   1 LLEHG-PIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDE-EGLTALDLA 56
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 120-259 3.72e-06

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 49.48  E-value: 3.72e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217288863 120 LQAILDGGVSPEEAtqvDSNGRTGLMVACYHGFQS-VVALLSH-CpflDVNQQDKGGDTALMLAAQAGHVPLVSLLLNY- 196
Cdd:PLN03192  541 LEELLKAKLDPDIG---DSKGRTPLHIAASKGYEDcVLVLLKHaC---NVHIRDANGNTALWNAISAKHHKIFRILYHFa 614

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2217288863 197 -----YVGLDLerrdqrgltaLMKAAMRNRCECVATLLMAGADLTAVDPvRGKTALEWAVLTDSFDTV 259
Cdd:PLN03192  615 sisdpHAAGDL----------LCTAAKRNDLTAMKELLKQGLNVDSEDH-QGATALQVAMAEDHVDMV 671
PHA03095 PHA03095
ankyrin-like protein; Provisional
 137-268 7.67e-05

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 45.02  E-value: 7.67e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217288863 137 DSNGRTGLMvaCYHGFQSVVALLShcpFL-----DVNQQDKGGDTAL--MLAAQAGHVPLVSLLLNYyvGLDLERRDQRG 209
Cdd:PHA03095   80 ERCGFTPLH--LYLYNATTLDVIK---LLikagaDVNAKDKVGRTPLhvYLSGFNINPKVIRLLLRK--GADVNALDLYG 152

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2217288863 210 LTALmKAAMRNR---CECVATLLMAGADLTAVDpVRGKTALEwaVLTDSFDTVWRI-RQLLRR 268
Cdd:PHA03095  153 MTPL-AVLLKSRnanVELLRLLIDAGADVYAVD-DRFRSLLH--HHLQSFKPRARIvRELIRA 211
Ank_2 pfam12796
Ankyrin repeats (3 copies);
213-280 9.45e-05

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 41.25  E-value: 9.45e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2217288863 213 LMKAAMRNRCECVATLLMAGADLTAVDPvRGKTALEWAVLTDSFDTVwriRQLLRRPQVEQLSQHYKP 280
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDK-NGRTALHLAAKNGHLEIV---KLLLEHADVNLKDNGRTA 64
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 169-268 6.24e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 42.31  E-value: 6.24e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217288863 169 QQDKGGDTALMLAAQAGHVPLVSLLLNYYvGLDLERRDQRGLTALMKAAMRNRCECVATLLMAGADLTAV----DPVRGK 244
Cdd:cd22192    12 QQKRISESPLLLAAKENDVQAIKKLLKCP-SCDLFQRGALGETALHVAALYDNLEAAVVLMEAAPELVNEpmtsDLYQGE 90

                          90       100
                  ....*....|....*....|....
gi 2217288863 245 TALEWAVLTDSFDTVwriRQLLRR 268
Cdd:cd22192    91 TALHIAVVNQNLNLV---RELIAR 111
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 190-253 1.34e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 40.80  E-value: 1.34e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2217288863 190 VSLLLNYyvGLDLERRDQRGLTALMKAAMRNRCECVATLLMAGADLTAVDpVRGKTALEWAVLT 253
Cdd:PHA03100  175 VNYLLSY--GVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVN-KYGDTPLHIAILN 235
PHA03095 PHA03095
ankyrin-like protein; Provisional
 166-272 2.04e-03

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 40.39  E-value: 2.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217288863 166 DVNQQDKGGDTALMLAAqAGHVPLVSLLLNYYV-GLDLERRDQRGLTALMKAA-MRNRCECvATLLMAGADLTAVDPvRG 243
Cdd:PHA03095  214 DPAATDMLGNTPLHSMA-TGSSCKRSLVLPLLIaGISINARNRYGQTPLHYAAvFNNPRAC-RRLIALGADINAVSS-DG 290

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2217288863 244 KTALEWAVL---TDSFDTVwrirqLLRRPQVE 272
Cdd:PHA03095  291 NTPLSLMVRnnnGRAVRAA-----LAKNPSAE 317
Ank_4 pfam13637
Ankyrin repeats (many copies);
104-159 2.49e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 36.10  E-value: 2.49e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2217288863 104 RLGALYWACVHNDPTQLQAILDGGVSPEEatqVDSNGRTGLMVACYHGFQSVVALL 159
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINA---VDGNGETALHFAASNGNVEVLKLL 53
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 208-239 3.96e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 34.96  E-value: 3.96e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 2217288863 208 RGLTALMKAAMRNRC-ECVATLLMAGADLTAVD 239
Cdd:pfam00023   1 DGNTPLHLAAGRRGNlEIVKLLLSKGADVNARD 33
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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