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Conserved domains on  [gi|2217295388|ref|XP_047286714|]
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cell division cycle protein 16 homolog isoform X10 [Homo sapiens]

Protein Classification

CDC27 family protein( domain architecture ID 12124077)

cell division cycle 27 family protein similar to cell division cycle 27 (CDC27, also known as APC3) and cell division cycle 27 (CDC16, also known as APC6) which are tetratricopeptide repeat-containing components of the Anaphase-promoting complex (APC)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANAPC3 pfam12895
Anaphase-promoting complex, cyclosome, subunit 3; Apc3, otherwise known as Cdc27, is one of ...
 15-94 7.67e-21

Anaphase-promoting complex, cyclosome, subunit 3; Apc3, otherwise known as Cdc27, is one of the subunits of the anaphase-promoting complex or cyclosome. The anaphase-promoting complex is a multiprotein subunit E3 ubiquitin ligase complex that controls segregation of chromosomes and exit from mitosis in eukaryotes. The protein members of this family contain TPR repeats just as those of Apc7 do, and it appears that these TPR units bind the C-termini of the APC co-activators CDH1 and CDC20.


:

Pssm-ID: 463743 [Multi-domain]  Cd Length: 82  Bit Score: 85.77  E-value: 7.67e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217295388  15 DQQQYQSALFWADKVASLSREEPQDIYWLAQCLYLTAQYHRAAHALRSRKLDKLYEACRYLAARCHYAAKEHQQALDVLD 94
Cdd:pfam12895   1 DQHQYKNAIFLAERLLAAEPESPEDAYLLAQCLFLNGQYKRAYELLRKAKLNGSSLGCRYLFAQCLLKLKKYDEALDALG 80
Spy super family cl27809
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 275-363 4.27e-03

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


The actual alignment was detected with superfamily member COG3914:

Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 39.21  E-value: 4.27e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217295388 275 LVELNKANELFYLSHKLVDLYPSNPVSWFAVGCYYLMVGHKNEhARRYLSKATTLEKTYGPAWIAYGHSFAVESEHDQAM 354
Cdd:COG3914    88 LQALGRYEEALALYRRALALNPDNAEALFNLGNLLLALGRLEE-ALAALRRALALNPDFAEAYLNLGEALRRLGRLEEAI 166


                  ....*....
gi 2217295388 355 AAYFTAAQL 363
Cdd:COG3914   167 AALRRALEL 175
 
Name Accession Description Interval E-value
ANAPC3 pfam12895
Anaphase-promoting complex, cyclosome, subunit 3; Apc3, otherwise known as Cdc27, is one of ...
 15-94 7.67e-21

Anaphase-promoting complex, cyclosome, subunit 3; Apc3, otherwise known as Cdc27, is one of the subunits of the anaphase-promoting complex or cyclosome. The anaphase-promoting complex is a multiprotein subunit E3 ubiquitin ligase complex that controls segregation of chromosomes and exit from mitosis in eukaryotes. The protein members of this family contain TPR repeats just as those of Apc7 do, and it appears that these TPR units bind the C-termini of the APC co-activators CDH1 and CDC20.


Pssm-ID: 463743 [Multi-domain]  Cd Length: 82  Bit Score: 85.77  E-value: 7.67e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217295388  15 DQQQYQSALFWADKVASLSREEPQDIYWLAQCLYLTAQYHRAAHALRSRKLDKLYEACRYLAARCHYAAKEHQQALDVLD 94
Cdd:pfam12895   1 DQHQYKNAIFLAERLLAAEPESPEDAYLLAQCLFLNGQYKRAYELLRKAKLNGSSLGCRYLFAQCLLKLKKYDEALDALG 80
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 3-129 7.48e-07

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 48.08  E-value: 7.48e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217295388   3 LERLRKRVRQ--------------YLDQQQYQSALFWADKVASLSREEPQDIYWLAQCLYLTAQYHRAAHAL-RSRKLDK 67
Cdd:COG4235     3 IARLRQALAAnpndaegwlllgraYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLeRALALDP 82

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2217295388  68 LYEACRYLAARCHYAAKEHQQALDvldmeepinkrLFEKYLKDEsgfkDPSSDWEMSQSSIK 129
Cdd:COG4235    83 DNPEALYLLGLAAFQQGDYAEAIA-----------AWQKLLALL----PADAPARLLEASIA 129
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 275-363 4.27e-03

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 39.21  E-value: 4.27e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217295388 275 LVELNKANELFYLSHKLVDLYPSNPVSWFAVGCYYLMVGHKNEhARRYLSKATTLEKTYGPAWIAYGHSFAVESEHDQAM 354
Cdd:COG3914    88 LQALGRYEEALALYRRALALNPDNAEALFNLGNLLLALGRLEE-ALAALRRALALNPDFAEAYLNLGEALRRLGRLEEAI 166


                  ....*....
gi 2217295388 355 AAYFTAAQL 363
Cdd:COG3914   167 AALRRALEL 175
 
Name Accession Description Interval E-value
ANAPC3 pfam12895
Anaphase-promoting complex, cyclosome, subunit 3; Apc3, otherwise known as Cdc27, is one of ...
 15-94 7.67e-21

Anaphase-promoting complex, cyclosome, subunit 3; Apc3, otherwise known as Cdc27, is one of the subunits of the anaphase-promoting complex or cyclosome. The anaphase-promoting complex is a multiprotein subunit E3 ubiquitin ligase complex that controls segregation of chromosomes and exit from mitosis in eukaryotes. The protein members of this family contain TPR repeats just as those of Apc7 do, and it appears that these TPR units bind the C-termini of the APC co-activators CDH1 and CDC20.


Pssm-ID: 463743 [Multi-domain]  Cd Length: 82  Bit Score: 85.77  E-value: 7.67e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217295388  15 DQQQYQSALFWADKVASLSREEPQDIYWLAQCLYLTAQYHRAAHALRSRKLDKLYEACRYLAARCHYAAKEHQQALDVLD 94
Cdd:pfam12895   1 DQHQYKNAIFLAERLLAAEPESPEDAYLLAQCLFLNGQYKRAYELLRKAKLNGSSLGCRYLFAQCLLKLKKYDEALDALG 80
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 3-129 7.48e-07

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 48.08  E-value: 7.48e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217295388   3 LERLRKRVRQ--------------YLDQQQYQSALFWADKVASLSREEPQDIYWLAQCLYLTAQYHRAAHAL-RSRKLDK 67
Cdd:COG4235     3 IARLRQALAAnpndaegwlllgraYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLeRALALDP 82

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2217295388  68 LYEACRYLAARCHYAAKEHQQALDvldmeepinkrLFEKYLKDEsgfkDPSSDWEMSQSSIK 129
Cdd:COG4235    83 DNPEALYLLGLAAFQQGDYAEAIA-----------AWQKLLALL----PADAPARLLEASIA 129
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
13-94 2.16e-03

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 37.07  E-value: 2.16e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217295388  13 YLDQQQYQSALFWADKVASLSREEPQDIYWLAQCLYLTAQYHRAAHALRSRKLDKLYEACRYLAARCHYAAKEHQQALDV 92
Cdd:COG3063     2 YLKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAIALEKALKLDPNNAEALLNLAELLLELGDYDEALAY 81


                  ..
gi 2217295388  93 LD 94
Cdd:COG3063    82 LE 83
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 2-93 3.14e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 38.94  E-value: 3.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217295388   2 NLERLRKRVRQYLDQQQYQSALFWADKVASLSREEPQDIYWLAQCLYLTAQYHRAAHAL-RSRKLDKLYEACRYLAARCH 80
Cdd:COG2956   109 DAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIEALeKALKLDPDCARALLLLAELY 188

                          90
                  ....*....|...
gi 2217295388  81 YAAKEHQQALDVL 93
Cdd:COG2956   189 LEQGDYEEAIAAL 201
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 275-363 4.27e-03

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 39.21  E-value: 4.27e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217295388 275 LVELNKANELFYLSHKLVDLYPSNPVSWFAVGCYYLMVGHKNEhARRYLSKATTLEKTYGPAWIAYGHSFAVESEHDQAM 354
Cdd:COG3914    88 LQALGRYEEALALYRRALALNPDNAEALFNLGNLLLALGRLEE-ALAALRRALALNPDFAEAYLNLGEALRRLGRLEEAI 166


                  ....*....
gi 2217295388 355 AAYFTAAQL 363
Cdd:COG3914   167 AALRRALEL 175
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 3-160 8.16e-03

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 36.32  E-value: 8.16e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217295388   3 LERLRKRVRQYLDQQQYQSALFWADKVASLSREEPQDIYWLAQCLYLTAQYHRAAHAL-RSRKLDKLYEACRYLAARCHY 81
Cdd:COG4783     4 AEALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLhEALELDPDEPEARLNLGLALL 83

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2217295388  82 AAKEHQQALdvldmeepinkRLFEKYLKdesgfKDPSSdwemsqssikSSICLLRGKIYDALDNRTLATYSYKEALKLD 160
Cdd:COG4783    84 KAGDYDEAL-----------ALLEKALK-----LDPEH----------PEAYLRLARAYRALGRPDEAIAALEKALELD 136
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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