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Conserved domains on  [gi|2217296481|ref|XP_047286968|]
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leucine-rich repeat-containing protein 74A isoform X2 [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1006001)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RNA1 super family cl34950
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 75-332 3.99e-41

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


The actual alignment was detected with superfamily member COG5238:

Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 152.64  E-value: 3.99e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217296481  75 LMGVVPVSYFIRNMEESYVNLNHHGLGPRGTKAIAIALVSNMAVTKLELEDNCIMEEGVLSLVEMLQENYYLQEMNISNN 154
Cdd:COG5238   167 LLAAISMAKALQNNSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNN 246

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217296481 155 HLGLEGARIISDFFERNsSSIWSLELSGNDFKEDSAALLCQALSTNYQIKKLDLSHNQFSDVGGEHLGQMLAINVGLTSL 234
Cdd:COG5238   247 QIGDEGVIALAEALKNN-TTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGNKTLHTL 325

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217296481 235 DLSWNNFHTRGAVALCNGL-------RLDLSMNGFGNEVALALGEVLRLNRCLVYLDIGGNDIGNEGASKISKGLESNeS 307
Cdd:COG5238   326 NLAYNGIGAQGAIALAKALqenttlhSLDLSDNQIGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEALIDALQTN-R 404

                         250       260
                  ....*....|....*....|....*
gi 2217296481 308 LRVLKLFLNPINMDGAILLILAIKR 332
Cdd:COG5238   405 LHTLILDGNLIGAEAQQRLEQLLER 429
 
Name Accession Description Interval E-value
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 75-332 3.99e-41

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 152.64  E-value: 3.99e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217296481  75 LMGVVPVSYFIRNMEESYVNLNHHGLGPRGTKAIAIALVSNMAVTKLELEDNCIMEEGVLSLVEMLQENYYLQEMNISNN 154
Cdd:COG5238   167 LLAAISMAKALQNNSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNN 246

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217296481 155 HLGLEGARIISDFFERNsSSIWSLELSGNDFKEDSAALLCQALSTNYQIKKLDLSHNQFSDVGGEHLGQMLAINVGLTSL 234
Cdd:COG5238   247 QIGDEGVIALAEALKNN-TTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGNKTLHTL 325

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217296481 235 DLSWNNFHTRGAVALCNGL-------RLDLSMNGFGNEVALALGEVLRLNRCLVYLDIGGNDIGNEGASKISKGLESNeS 307
Cdd:COG5238   326 NLAYNGIGAQGAIALAKALqenttlhSLDLSDNQIGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEALIDALQTN-R 404

                         250       260
                  ....*....|....*....|....*
gi 2217296481 308 LRVLKLFLNPINMDGAILLILAIKR 332
Cdd:COG5238   405 LHTLILDGNLIGAEAQQRLEQLLER 429
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 95-344 2.69e-29

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 117.07  E-value: 2.69e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217296481  95 LNHHGLGPRGTKAIAIALVSNMAVTKLELEDNCIMEEGVlSLVEMLQENYYLQEMNISNNHLGLEGARIISDFFERNSSS 174
Cdd:cd00116    60 LNETGRIPRGLQSLLQGLTKGCGLQELDLSDNALGPDGC-GVLESLLRSSSLQELKLNNNGLGDRGLRLLAKGLKDLPPA 138

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217296481 175 IWSLELSGNDFKEDSAALLCQALSTNYQIKKLDLSHNQFSDVGGEHLGQMLAINVGLTSLDLsWNNFHTR-GAVALCNGL 253
Cdd:cd00116   139 LEKLVLGRNRLEGASCEALAKALRANRDLKELNLANNGIGDAGIRALAEGLKANCNLEVLDL-NNNGLTDeGASALAETL 217

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217296481 254 R-------LDLSMNGFGNEVALALGEVLR-LNRCLVYLDIGGNDIGNEGASKISKGLESNESLRVLKLFLNPINMDGAIL 325
Cdd:cd00116   218 AslkslevLNLGDNNLTDAGAAALASALLsPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGAQL 297

                         250       260
                  ....*....|....*....|.
gi 2217296481 326 L--ILAIKRNPKSRMEELDIS 344
Cdd:cd00116   298 LaeSLLEPGNELESLWVKDDS 318
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 171-316 4.88e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 42.91  E-value: 4.88e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217296481 171 NSSSIWSLELSGndfKEDSAALLCQALSTNYqIKKLDLSHNQFSdvgGEHLGQMLAINVGLTSLDLSWNNFH---TRGAV 247
Cdd:PLN00113   67 NSSRVVSIDLSG---KNISGKISSAIFRLPY-IQTINLSNNQLS---GPIPDDIFTTSSSLRYLNLSNNNFTgsiPRGSI 139

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2217296481 248 ALCNglRLDLSMNGFGNEVALALGEVLRLNrclvYLDIGGNDIgnegASKISKGLESNESLRVLKLFLN 316
Cdd:PLN00113  140 PNLE--TLDLSNNMLSGEIPNDIGSFSSLK----VLDLGGNVL----VGKIPNSLTNLTSLEFLTLASN 198
LRR_6 pfam13516
Leucine Rich repeat;
277-299 9.24e-04

Leucine Rich repeat;


Pssm-ID: 463907 [Multi-domain]  Cd Length: 24  Bit Score: 36.44  E-value: 9.24e-04
                          10        20
                  ....*....|....*....|...
gi 2217296481 277 NRCLVYLDIGGNDIGNEGASKIS 299
Cdd:pfam13516   2 NTHLTTLDLSDNDIGDEGAEALA 24
 
Name Accession Description Interval E-value
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 75-332 3.99e-41

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 152.64  E-value: 3.99e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217296481  75 LMGVVPVSYFIRNMEESYVNLNHHGLGPRGTKAIAIALVSNMAVTKLELEDNCIMEEGVLSLVEMLQENYYLQEMNISNN 154
Cdd:COG5238   167 LLAAISMAKALQNNSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNN 246

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217296481 155 HLGLEGARIISDFFERNsSSIWSLELSGNDFKEDSAALLCQALSTNYQIKKLDLSHNQFSDVGGEHLGQMLAINVGLTSL 234
Cdd:COG5238   247 QIGDEGVIALAEALKNN-TTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGNKTLHTL 325

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217296481 235 DLSWNNFHTRGAVALCNGL-------RLDLSMNGFGNEVALALGEVLRLNRCLVYLDIGGNDIGNEGASKISKGLESNeS 307
Cdd:COG5238   326 NLAYNGIGAQGAIALAKALqenttlhSLDLSDNQIGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEALIDALQTN-R 404

                         250       260
                  ....*....|....*....|....*
gi 2217296481 308 LRVLKLFLNPINMDGAILLILAIKR 332
Cdd:COG5238   405 LHTLILDGNLIGAEAQQRLEQLLER 429
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 108-344 1.81e-32

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 128.37  E-value: 1.81e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217296481 108 IAIALVSNMAVTKLELEDNCIMEEGVLSLVEMLQE--NYYLQEMNISNNHLGLEGARIISDFFERNsSSIWSLELSGNDF 185
Cdd:COG5238   142 NLIQVLKDPLGGNAVHLLGLAARLGLLAAISMAKAlqNNSVETVYLGCNQIGDEGIEELAEALTQN-TTVTTLWLKRNPI 220

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217296481 186 KEDSAALLCQALSTNYQIKKLDLSHNQFSDVGGEHLGQMLAINVGLTSLDLSWNNFHTRGAVALCNGLR-------LDLS 258
Cdd:COG5238   221 GDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALQgnttltsLDLS 300

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217296481 259 MNGFGNEVALALGEVLRLNRCLVYLDIGGNDIGNEGASKISKGLESNESLRVLKLFLNPINMDGAILLILAIKRNPKSRm 338
Cdd:COG5238   301 VNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNTTLR- 379


                  ....*.
gi 2217296481 339 eELDIS 344
Cdd:COG5238   380 -ELNLG 384
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 154-366 1.97e-30

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 122.59  E-value: 1.97e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217296481 154 NHLGLEGAriISDFFERNSSSIWSLELSGNDFKEDSAALLCQALSTNYQIKKLDLSHNQFSDVGGEHLGQMLAINVGLTS 233
Cdd:COG5238   163 ARLGLLAA--ISMAKALQNNSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSLTT 240

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217296481 234 LDLSWNNFHTRGAVALCNGL-------RLDLSMNGFGNEVALALGEVLRLNRCLVYLDIGGNDIGNEGASKISKGLESNE 306
Cdd:COG5238   241 LDLSNNQIGDEGVIALAEALknnttveTLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGNK 320

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217296481 307 SLRVLKLFLNPINMDGAILLILAIKRNPKsrMEELDISNVLVSEQFMKTLDGVYAVHPQL 366
Cdd:COG5238   321 TLHTLNLAYNGIGAQGAIALAKALQENTT--LHSLDLSDNQIGDEGAIALAKYLEGNTTL 378
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 95-344 2.69e-29

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 117.07  E-value: 2.69e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217296481  95 LNHHGLGPRGTKAIAIALVSNMAVTKLELEDNCIMEEGVlSLVEMLQENYYLQEMNISNNHLGLEGARIISDFFERNSSS 174
Cdd:cd00116    60 LNETGRIPRGLQSLLQGLTKGCGLQELDLSDNALGPDGC-GVLESLLRSSSLQELKLNNNGLGDRGLRLLAKGLKDLPPA 138

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217296481 175 IWSLELSGNDFKEDSAALLCQALSTNYQIKKLDLSHNQFSDVGGEHLGQMLAINVGLTSLDLsWNNFHTR-GAVALCNGL 253
Cdd:cd00116   139 LEKLVLGRNRLEGASCEALAKALRANRDLKELNLANNGIGDAGIRALAEGLKANCNLEVLDL-NNNGLTDeGASALAETL 217

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217296481 254 R-------LDLSMNGFGNEVALALGEVLR-LNRCLVYLDIGGNDIGNEGASKISKGLESNESLRVLKLFLNPINMDGAIL 325
Cdd:cd00116   218 AslkslevLNLGDNNLTDAGAAALASALLsPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGAQL 297

                         250       260
                  ....*....|....*....|.
gi 2217296481 326 L--ILAIKRNPKSRMEELDIS 344
Cdd:cd00116   298 LaeSLLEPGNELESLWVKDDS 318
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 85-344 1.92e-27

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 112.06  E-value: 1.92e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217296481  85 IRNMEEsyVNLNHHGLGPRGTKAIAIALVSNMAVTKLELEDNCI--MEEGVLSLVEMLQENYYLQEMNISNNHLGLEGAR 162
Cdd:cd00116    22 LLCLQV--LRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETgrIPRGLQSLLQGLTKGCGLQELDLSDNALGPDGCG 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217296481 163 IISDFfeRNSSSIWSLELSGNDFKEDSAALLCQAL-STNYQIKKLDLSHNQFSDVGGEHLGQMLAINVGLTSLDLSWNNF 241
Cdd:cd00116   100 VLESL--LRSSSLQELKLNNNGLGDRGLRLLAKGLkDLPPALEKLVLGRNRLEGASCEALAKALRANRDLKELNLANNGI 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217296481 242 HTRGAVALCNGL-------RLDLSMNGFGNEVALALGEVLRLNRCLVYLDIGGNDIGNEGASKISKGLES-NESLRVLKL 313
Cdd:cd00116   178 GDAGIRALAEGLkancnleVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDAGAAALASALLSpNISLLTLSL 257

                         250       260       270
                  ....*....|....*....|....*....|.
gi 2217296481 314 FLNPINMDGAILLILAIKRNPksRMEELDIS 344
Cdd:cd00116   258 SCNDITDDGAKDLAEVLAEKE--SLLELDLR 286
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 84-226 1.78e-17

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 83.17  E-value: 1.78e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217296481  84 FIRNMEEsyVNLNHHGLGPRGTKAIAIALVSNMAVTKLELEDNCIMEEGVLSLVEMLQENYYLQEMNISNNHLGLEGARI 163
Cdd:cd00116   163 ANRDLKE--LNLANNGIGDAGIRALAEGLKANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDAGAAA 240

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2217296481 164 ISDFFERNSSSIWSLELSGNDFKEDSAALLCQALSTNYQIKKLDLSHNQFSDVGGEHLGQMLA 226
Cdd:cd00116   241 LASALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGAQLLAESLL 303
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
155-345 2.80e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 49.55  E-value: 2.80e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217296481 155 HLGLEGARIISDFfernsSSIWSLELSGNDFKEdsaalLCQALSTNYQIKKLDLSHNQFSDVGGEhLGQMlainVGLTSL 234
Cdd:COG4886   100 ELDLSGNEELSNL-----TNLESLDLSGNQLTD-----LPEELANLTNLKELDLSNNQLTDLPEP-LGNL----TNLKSL 164

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217296481 235 DLSWNNFHT-RGAVALCNGLR-LDLSMNGFgNEVALALGEvlrLNRcLVYLDIGGNDIgnegaSKISKGLESNESLRVLK 312
Cdd:COG4886   165 DLSNNQLTDlPEELGNLTNLKeLDLSNNQI-TDLPEPLGN---LTN-LEELDLSGNQL-----TDLPEPLANLTNLETLD 234

                         170       180       190
                  ....*....|....*....|....*....|...
gi 2217296481 313 LFLNPINmdgailLILAIKRNPKsrMEELDISN 345
Cdd:COG4886   235 LSNNQLT------DLPELGNLTN--LEELDLSN 259
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
89-318 1.47e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 47.24  E-value: 1.47e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217296481  89 EESYVNLNHHGLGPRGTKAIAIALVSNMAVTKLELEDNCIMEEGVLSLVEMLQENYYLQEMNISNNHLGLEGARI----- 163
Cdd:COG4886    58 RDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDLPEELanltn 137

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217296481 164 ----------ISDFFE--RNSSSIWSLELSGNDFKEdsaalLCQALSTNYQIKKLDLSHNQFSDVGGEhLGQMlainVGL 231
Cdd:COG4886   138 lkeldlsnnqLTDLPEplGNLTNLKSLDLSNNQLTD-----LPEELGNLTNLKELDLSNNQITDLPEP-LGNL----TNL 207

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217296481 232 TSLDLSWNNFHT-RGAVALCNGLR-LDLSMNGFGNevalaLGEVLRLNRcLVYLDIGGNDIgnegaSKISKgLESNESLR 309
Cdd:COG4886   208 EELDLSGNQLTDlPEPLANLTNLEtLDLSNNQLTD-----LPELGNLTN-LEELDLSNNQL-----TDLPP-LANLTNLK 275


                  ....*....
gi 2217296481 310 VLKLFLNPI 318
Cdd:COG4886   276 TLDLSNNQL 284
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 171-316 4.88e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 42.91  E-value: 4.88e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217296481 171 NSSSIWSLELSGndfKEDSAALLCQALSTNYqIKKLDLSHNQFSdvgGEHLGQMLAINVGLTSLDLSWNNFH---TRGAV 247
Cdd:PLN00113   67 NSSRVVSIDLSG---KNISGKISSAIFRLPY-IQTINLSNNQLS---GPIPDDIFTTSSSLRYLNLSNNNFTgsiPRGSI 139

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2217296481 248 ALCNglRLDLSMNGFGNEVALALGEVLRLNrclvYLDIGGNDIgnegASKISKGLESNESLRVLKLFLN 316
Cdd:PLN00113  140 PNLE--TLDLSNNMLSGEIPNDIGSFSSLK----VLDLGGNVL----VGKIPNSLTNLTSLEFLTLASN 198
LRR_6 pfam13516
Leucine Rich repeat;
277-299 9.24e-04

Leucine Rich repeat;


Pssm-ID: 463907 [Multi-domain]  Cd Length: 24  Bit Score: 36.44  E-value: 9.24e-04
                          10        20
                  ....*....|....*....|...
gi 2217296481 277 NRCLVYLDIGGNDIGNEGASKIS 299
Cdd:pfam13516   2 NTHLTTLDLSDNDIGDEGAEALA 24
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 119-239 7.24e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 37.84  E-value: 7.24e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217296481 119 TKLELEDNCImeegvlSLVEMLQENYYLQEMNISNNHLGlEGARIISDffernSSSIWS-------LELSGN--DFKEDS 189
Cdd:cd21340    71 KKLYLGGNRI------SVVEGLENLTNLEELHIENQRLP-PGEKLTFD-----PRSLAAlsnslrvLNISGNniDSLEPL 138

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 2217296481 190 AALlcqalstnYQIKKLDLSHNQFSDVggEHLGQMLAINVGLTSLDLSWN 239
Cdd:cd21340   139 APL--------RNLEQLDASNNQISDL--EELLDLLSSWPSLRELDLTGN 178
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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