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Conserved domains on  [gi|2217300627|ref|XP_047288279|]
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protein ENTREP2 isoform X2 [Homo sapiens]

Protein Classification

CD20-like domain-containing protein( domain architecture ID 10513721)

CD20-like domain-containing protein similar to Homo sapiens B-lymphocyte antigen CD20 that may be involved in the regulation of B-cell activation and proliferation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CD20 pfam04103
CD20-like family; This family includes the CD20 protein and the beta subunit of the high ...
 34-199 2.35e-19

CD20-like family; This family includes the CD20 protein and the beta subunit of the high affinity receptor for IgE Fc. The high affinity receptor for IgE is a tetrameric structure consisting of a single IgE-binding alpha subunit, a single beta subunit, and two disulfide-linked gamma subunits. The alpha subunit of Fc epsilon RI and most Fc receptors are homologous members of the Ig superfamily. By contrast, the beta and gamma subunits from Fc epsilon RI are not homologous to the Ig superfamily. Both molecules have four putative transmembrane segments and a probably topology where both amino- and carboxy termini protrude into the cytoplasm. This family also includes LR8 like proteins from humans, mice and rats. The function of the human LR8 protein is unknown although it is known to be strongly expressed in the lung fibroblasts. This family also includes sarcospan is a transmembrane component of dystrophin-associated glycoprotein. Loss of the sarcoglycan complex and sarcospan alone is sufficient to cause muscular dystrophy. The role of the sarcoglycan complex and sarcospan is thought to be to strengthen the dystrophin axis connecting the basement membrane with the cytoskeleton.


:

Pssm-ID: 461174  Cd Length: 155  Bit Score: 85.01  E-value: 2.35e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217300627  34 ALGATQMALGCLIVAVSFAALALTTSARVRHsCPFWAGFSVLLSGLIGVVSWKRPLSLVITFFMLLSAVCVMLNLAGSIL 113
Cdd:pfam04103   1 VLGVVQILLGLLSIVLGFILYSVSSSLLASG-YPFWGGIIFIISGVLGIAAEKRSTKLLVLLSLLLNLLSLFTAVAGIIL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217300627 114 SCQN-AQLVNSLEGCQLIK--FDSVEVCVCCELQHQSSGCsnlgetlklnplqENCNAVRLTLKDLLFSVCALNVLSTIV 190
Cdd:pfam04103  80 LSLSlALLTSAHECCMSESdlTPSTSTCSCKSSSEDPECR-------------AYCSSLRGLFTGILSMLLILTVLELLV 146


                  ....*....
gi 2217300627 191 CALATAMCC 199
Cdd:pfam04103 147 SLLSAILGC 155
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 271-478 3.37e-07

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 53.40  E-value: 3.37e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217300627  271 APSPFGTLYDVAINSPGLLYPAELPPPYEAVVGQPPASQVtsiGQQVAESSSGDPNTSAGFSTPV-PADSTSLLVSEGTA 349
Cdd:PHA03247  2688 ARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAA---ARQASPALPAAPAPPAVPAGPAtPGGPARPARPPTTA 2764

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217300627  350 TPGSSPSPDGPVGAPAPSEPALPPGHVSPEDPGMGSQVQPGPGRVSRSTSDPTLCTSSMAGDASSHRPSCSQDLEAGLSE 429
Cdd:PHA03247  2765 GPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPG 2844

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*....
gi 2217300627  430 AVPGSASMSRSataacraqLSPAGDpdtwkTDQRPTPEPFPATSKERPR 478
Cdd:PHA03247  2845 PPPPSLPLGGS--------VAPGGD-----VRRRPPSRSPAAKPAAPAR 2880
 
Name Accession Description Interval E-value
CD20 pfam04103
CD20-like family; This family includes the CD20 protein and the beta subunit of the high ...
 34-199 2.35e-19

CD20-like family; This family includes the CD20 protein and the beta subunit of the high affinity receptor for IgE Fc. The high affinity receptor for IgE is a tetrameric structure consisting of a single IgE-binding alpha subunit, a single beta subunit, and two disulfide-linked gamma subunits. The alpha subunit of Fc epsilon RI and most Fc receptors are homologous members of the Ig superfamily. By contrast, the beta and gamma subunits from Fc epsilon RI are not homologous to the Ig superfamily. Both molecules have four putative transmembrane segments and a probably topology where both amino- and carboxy termini protrude into the cytoplasm. This family also includes LR8 like proteins from humans, mice and rats. The function of the human LR8 protein is unknown although it is known to be strongly expressed in the lung fibroblasts. This family also includes sarcospan is a transmembrane component of dystrophin-associated glycoprotein. Loss of the sarcoglycan complex and sarcospan alone is sufficient to cause muscular dystrophy. The role of the sarcoglycan complex and sarcospan is thought to be to strengthen the dystrophin axis connecting the basement membrane with the cytoskeleton.


Pssm-ID: 461174  Cd Length: 155  Bit Score: 85.01  E-value: 2.35e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217300627  34 ALGATQMALGCLIVAVSFAALALTTSARVRHsCPFWAGFSVLLSGLIGVVSWKRPLSLVITFFMLLSAVCVMLNLAGSIL 113
Cdd:pfam04103   1 VLGVVQILLGLLSIVLGFILYSVSSSLLASG-YPFWGGIIFIISGVLGIAAEKRSTKLLVLLSLLLNLLSLFTAVAGIIL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217300627 114 SCQN-AQLVNSLEGCQLIK--FDSVEVCVCCELQHQSSGCsnlgetlklnplqENCNAVRLTLKDLLFSVCALNVLSTIV 190
Cdd:pfam04103  80 LSLSlALLTSAHECCMSESdlTPSTSTCSCKSSSEDPECR-------------AYCSSLRGLFTGILSMLLILTVLELLV 146


                  ....*....
gi 2217300627 191 CALATAMCC 199
Cdd:pfam04103 147 SLLSAILGC 155
PHA03247 PHA03247
large tegument protein UL36; Provisional
 271-478 3.37e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 53.40  E-value: 3.37e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217300627  271 APSPFGTLYDVAINSPGLLYPAELPPPYEAVVGQPPASQVtsiGQQVAESSSGDPNTSAGFSTPV-PADSTSLLVSEGTA 349
Cdd:PHA03247  2688 ARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAA---ARQASPALPAAPAPPAVPAGPAtPGGPARPARPPTTA 2764

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217300627  350 TPGSSPSPDGPVGAPAPSEPALPPGHVSPEDPGMGSQVQPGPGRVSRSTSDPTLCTSSMAGDASSHRPSCSQDLEAGLSE 429
Cdd:PHA03247  2765 GPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPG 2844

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*....
gi 2217300627  430 AVPGSASMSRSataacraqLSPAGDpdtwkTDQRPTPEPFPATSKERPR 478
Cdd:PHA03247  2845 PPPPSLPLGGS--------VAPGGD-----VRRRPPSRSPAAKPAAPAR 2880
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 287-468 6.38e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 42.83  E-value: 6.38e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217300627 287 GLLYPAELPPPYEAVVGQP-PASQVTSIGQQVAESSSGDPNTSAGFSTPVpadstSLLVSEGTATPGSSPSPDGPVgAPA 365
Cdd:pfam03154 179 GAASPPSPPPPGTTQAATAgPTPSAPSVPPQGSPATSQPPNQTQSTAAPH-----TLIQQTPTLHPQRLPSPHPPL-QPM 252

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217300627 366 PSEPalPPGHVSPE---DPGMGSQVQPGPGRVSrstSDPTLCTSSMAGDASSHRPSCSQ-DLEAGLSEAVPGSASmSRSA 441
Cdd:pfam03154 253 TQPP--PPSQVSPQplpQPSLHGQMPPMPHSLQ---TGPSHMQHPVPPQPFPLTPQSSQsQVPPGPSPAAPGQSQ-QRIH 326

                         170       180
                  ....*....|....*....|....*..
gi 2217300627 442 TAACRAQLSPAGDPDTWKTDQRPTPEP 468
Cdd:pfam03154 327 TPPSQSQLQSQQPPREQPLPPAPLSMP 353
 
Name Accession Description Interval E-value
CD20 pfam04103
CD20-like family; This family includes the CD20 protein and the beta subunit of the high ...
 34-199 2.35e-19

CD20-like family; This family includes the CD20 protein and the beta subunit of the high affinity receptor for IgE Fc. The high affinity receptor for IgE is a tetrameric structure consisting of a single IgE-binding alpha subunit, a single beta subunit, and two disulfide-linked gamma subunits. The alpha subunit of Fc epsilon RI and most Fc receptors are homologous members of the Ig superfamily. By contrast, the beta and gamma subunits from Fc epsilon RI are not homologous to the Ig superfamily. Both molecules have four putative transmembrane segments and a probably topology where both amino- and carboxy termini protrude into the cytoplasm. This family also includes LR8 like proteins from humans, mice and rats. The function of the human LR8 protein is unknown although it is known to be strongly expressed in the lung fibroblasts. This family also includes sarcospan is a transmembrane component of dystrophin-associated glycoprotein. Loss of the sarcoglycan complex and sarcospan alone is sufficient to cause muscular dystrophy. The role of the sarcoglycan complex and sarcospan is thought to be to strengthen the dystrophin axis connecting the basement membrane with the cytoskeleton.


Pssm-ID: 461174  Cd Length: 155  Bit Score: 85.01  E-value: 2.35e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217300627  34 ALGATQMALGCLIVAVSFAALALTTSARVRHsCPFWAGFSVLLSGLIGVVSWKRPLSLVITFFMLLSAVCVMLNLAGSIL 113
Cdd:pfam04103   1 VLGVVQILLGLLSIVLGFILYSVSSSLLASG-YPFWGGIIFIISGVLGIAAEKRSTKLLVLLSLLLNLLSLFTAVAGIIL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217300627 114 SCQN-AQLVNSLEGCQLIK--FDSVEVCVCCELQHQSSGCsnlgetlklnplqENCNAVRLTLKDLLFSVCALNVLSTIV 190
Cdd:pfam04103  80 LSLSlALLTSAHECCMSESdlTPSTSTCSCKSSSEDPECR-------------AYCSSLRGLFTGILSMLLILTVLELLV 146


                  ....*....
gi 2217300627 191 CALATAMCC 199
Cdd:pfam04103 147 SLLSAILGC 155
PHA03247 PHA03247
large tegument protein UL36; Provisional
 271-478 3.37e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 53.40  E-value: 3.37e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217300627  271 APSPFGTLYDVAINSPGLLYPAELPPPYEAVVGQPPASQVtsiGQQVAESSSGDPNTSAGFSTPV-PADSTSLLVSEGTA 349
Cdd:PHA03247  2688 ARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAA---ARQASPALPAAPAPPAVPAGPAtPGGPARPARPPTTA 2764

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217300627  350 TPGSSPSPDGPVGAPAPSEPALPPGHVSPEDPGMGSQVQPGPGRVSRSTSDPTLCTSSMAGDASSHRPSCSQDLEAGLSE 429
Cdd:PHA03247  2765 GPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPG 2844

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*....
gi 2217300627  430 AVPGSASMSRSataacraqLSPAGDpdtwkTDQRPTPEPFPATSKERPR 478
Cdd:PHA03247  2845 PPPPSLPLGGS--------VAPGGD-----VRRRPPSRSPAAKPAAPAR 2880
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 323-490 4.67e-05

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 46.32  E-value: 4.67e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217300627  323 GDPNTSAGFSTPVPADSTSLLVSEGTATPGSS--------PSPDGPVGAPAPSEPALPPGHVSPEDPGMGSQVQPGPGRV 394
Cdd:PHA03307    69 TGPPPGPGTEAPANESRSTPTWSLSTLAPASParegsptpPGPSSPDPPPPTPPPASPPPSPAPDLSEMLRPVGSPGPPP 148

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217300627  395 SRSTSDPTLCTSSMAGDASShrPSCSQDLEAGLSEAVPGSASMSRSATAACRAQLSPAGDPDTWKTDQRPTPEPFPATSK 474
Cdd:PHA03307   149 AASPPAAGASPAAVASDAAS--SRQAALPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGR 226

                          170       180
                   ....*....|....*....|
gi 2217300627  475 E----RPRSLVDSKAYADAR 490
Cdd:PHA03307   227 SaaddAGASSSDSSSSESSG 246
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 291-479 2.48e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 44.01  E-value: 2.48e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217300627  291 PAELPPPYEAVVGQPPASQVTSIGQQVAESSSGDPNTSAGFSTPVPADSTSLLVSEGTA------TPGSSPSPDGPVGAP 364
Cdd:PHA03307   190 PAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGwgpeneCPLPRPAPITLPTRI 269

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217300627  365 APSEPALP----PGHVSPEDPGMGSQVQPGPGR-VSRSTSDPTLCTSSMAGDASSHRPSCSQDLEAGLSEAVPGSASMSR 439
Cdd:PHA03307   270 WEASGWNGpssrPGPASSSSSPRERSPSPSPSSpGSGPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSR 349

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|...
gi 2217300627  440 SATAAcraqlSPAGDPDTWKTDQRPTPE---PFPATSKERPRS 479
Cdd:PHA03307   350 SPSPS-----RPPPPADPSSPRKRPRPSrapSSPAASAGRPTR 387
PHA03247 PHA03247
large tegument protein UL36; Provisional
 280-470 4.28e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.39  E-value: 4.28e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217300627  280 DVAINSPGLLYPAELPPPYEAVVGQP-PASQVTSIGQQVAESSSGDPNTSAGFSTPVPADSTSLLVSEGTATPGSSPSPD 358
Cdd:PHA03247  2546 DDAGDPPPPLPPAAPPAAPDRSVPPPrPAPRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPD 2625

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217300627  359 GPVGAPAPSEPALPPGHVSPEDPGMGSQVQPGPGRVSRstsdptlctssmagdassHRPSCSQDLEAGLSEAVPGSasmS 438
Cdd:PHA03247  2626 PPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSR------------------PRRARRLGRAAQASSPPQRP---R 2684

                          170       180       190
                   ....*....|....*....|....*....|..
gi 2217300627  439 RSATAACRAQLSPAGDPdtwkTDQRPTPEPFP 470
Cdd:PHA03247  2685 RRAARPTVGSLTSLADP----PPPPPTPEPAP 2712
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 287-468 6.38e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 42.83  E-value: 6.38e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217300627 287 GLLYPAELPPPYEAVVGQP-PASQVTSIGQQVAESSSGDPNTSAGFSTPVpadstSLLVSEGTATPGSSPSPDGPVgAPA 365
Cdd:pfam03154 179 GAASPPSPPPPGTTQAATAgPTPSAPSVPPQGSPATSQPPNQTQSTAAPH-----TLIQQTPTLHPQRLPSPHPPL-QPM 252

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217300627 366 PSEPalPPGHVSPE---DPGMGSQVQPGPGRVSrstSDPTLCTSSMAGDASSHRPSCSQ-DLEAGLSEAVPGSASmSRSA 441
Cdd:pfam03154 253 TQPP--PPSQVSPQplpQPSLHGQMPPMPHSLQ---TGPSHMQHPVPPQPFPLTPQSSQsQVPPGPSPAAPGQSQ-QRIH 326

                         170       180
                  ....*....|....*....|....*..
gi 2217300627 442 TAACRAQLSPAGDPDTWKTDQRPTPEP 468
Cdd:pfam03154 327 TPPSQSQLQSQQPPREQPLPPAPLSMP 353
PRK12495 PRK12495
hypothetical protein; Provisional
 315-455 9.52e-04

hypothetical protein; Provisional


Pssm-ID: 183558 [Multi-domain]  Cd Length: 226  Bit Score: 41.01  E-value: 9.52e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217300627 315 QQVAESSSGDPNTSAGFSTPVPADSTSLLVSEGTATPGSSPSPDGPVGAPAPSEPALPPGHVSPEDPGMGSQVQPGPGRV 394
Cdd:PRK12495   66 QPVTEDGAAGDDAGDGAEATAPSDAGSQASPDDDAQPAAEAEAADQSAPPEASSTSATDEAATDPPATAAARDGPTPDPT 145

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2217300627 395 SRSTSDPTLCTSSMAGDASSHRPSCSQDLEAGLSEAVPGSASMSRSATAACRaQLSPAGDP 455
Cdd:PRK12495  146 AQPATPDERRSPRQRPPVSGEPPTPSTPDAHVAGTLQAARESLVETLARFAR-RAAATDDP 205
PHA03378 PHA03378
EBNA-3B; Provisional
 253-491 1.29e-03

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 41.59  E-value: 1.29e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217300627 253 EYTCTPSTEAQRGlHLDFAPSPFGTLYDVAIN-SPGLLY-----PAELPPPYEA-VVGQPPASQVTSIGQQVAESSSGDP 325
Cdd:PHA03378  658 EITPYKPTWTQIG-HIPYQPSPTGANTMLPIQwAPGTMQpppraPTPMRPPAAPpGRAQRPAAATGRARPPAAAPGRARP 736

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217300627 326 NTSAGFSTPVPAdSTSLLVSEGTATPGSSPSPDGPVGAPAPSEPALPPghvspedPGMGSQVQPGPGRVSRSTSDPT--- 402
Cdd:PHA03378  737 PAAAPGRARPPA-AAPGRARPPAAAPGRARPPAAAPGAPTPQPPPQAP-------PAPQQRPRGAPTPQPPPQAGPTsmq 808

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217300627 403 LCTSSMAGDASSHRPSCSQDLEAGLSEAVPGSASMSRSATAACRAQLSPAGDPDTWKTDQRPTPEPFPATSKERPRSLVD 482
Cdd:PHA03378  809 LMPRAAPGQQGPTKQILRQLLTGGVKRGRPSLKKPAALERQAAAGPTPSPGSGTSDKIVQAPVFYPPVLQPIQVMRQLGS 888


                  ....*....
gi 2217300627 483 SKAYADARV 491
Cdd:PHA03378  889 VRAAAASTV 897
PRK13729 PRK13729
conjugal transfer pilus assembly protein TraB; Provisional
 318-398 1.55e-03

conjugal transfer pilus assembly protein TraB; Provisional


Pssm-ID: 184281 [Multi-domain]  Cd Length: 475  Bit Score: 40.96  E-value: 1.55e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217300627 318 AESSSGDPNTSAGfsTPVPADSTSLLVSEGTATPGSSPSPDGPVGAPAPSEP-ALPPGHVSPEDPGMGSQVQPGPGRVSR 396
Cdd:PRK13729  120 VKALGANPVTATG--EPVPQMPASPPGPEGEPQPGNTPVSFPPQGSVAVPPPtAFYPGNGVTPPPQVTYQSVPVPNRIQR 197


                  ..
gi 2217300627 397 ST 398
Cdd:PRK13729  198 KT 199
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
269-478 1.63e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 41.40  E-value: 1.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217300627 269 DFAPSPFGTLYDVAINSPGLLYPAELPPPYEAVVGQPPASQVTSIGQQVAESSSGDPntsagfstPVPADSTSLLVSEGT 348
Cdd:PRK12323  371 GAGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRS--------PAPEALAAARQASAR 442

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217300627 349 ATPGSSPSPDGPVGAPAPSEPALPPGHVSPEDPGMGSQVQPGPGRVSRSTSDPTLCTSSMAGDASSHRPScsqDLEAGLS 428
Cdd:PRK12323  443 GPGGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPPEFASPAPA---QPDAAPA 519

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 2217300627 429 EAVpgSASMSRSATAACRAQLSPAGDPDTWKTDQRPTPEPFPATSKERPR 478
Cdd:PRK12323  520 GWV--AESIPDPATADPDDAFETLAPAPAAAPAPRAAAATEPVVAPRPPR 567
motB PRK12799
flagellar motor protein MotB; Reviewed
 307-418 3.39e-03

flagellar motor protein MotB; Reviewed


Pssm-ID: 183756 [Multi-domain]  Cd Length: 421  Bit Score: 40.08  E-value: 3.39e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217300627 307 ASQVTSIGQQVAESSSGDPNTSAGFSTPVPADSTSLLVSEGTAT--PGSSPSPDGPVGAPAPSEPALPPGHVSPEDPGMG 384
Cdd:PRK12799  303 AVTPSSAVTQSSAITPSSAAIPSPAVIPSSVTTQSATTTQASAValSSAGVLPSDVTLPGTVALPAAEPVNMQPQPMSTT 382

                          90       100       110
                  ....*....|....*....|....*....|....
gi 2217300627 385 SQVQPGPGRVSRSTSDPTlcTSSMAGDASSHRPS 418
Cdd:PRK12799  383 ETQQSSTGNITSTANGPT--TSLPAAPASNIPVS 414
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 285-479 4.48e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 40.15  E-value: 4.48e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217300627  285 SPGLLYPAELPPPYEAVVGQPPASQVTSIGQQVAESSSGDPNTSAG---FSTPVPADSTSLLVSEGTATPGSSPSPDGPV 361
Cdd:PHA03307   125 SPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRqaaLPLSSPEETARAPSSPPAEPPPSTPPAAASP 204

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217300627  362 GAPAPSEPALPPGHVSPEDPGMGSQVQPGPGRVSRSTSDPTLCTSSMAGDASSHRPScSQDLEAGLSEAVPGSASMSRSA 441
Cdd:PHA03307   205 RPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENECPLPRPA-PITLPTRIWEASGWNGPSSRPG 283

                          170       180       190
                   ....*....|....*....|....*....|....*...
gi 2217300627  442 TAACRAQLSPAGDPDTWKTDQRPTPEPFPATSKERPRS 479
Cdd:PHA03307   284 PASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSS 321
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 295-499 6.30e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 39.58  E-value: 6.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217300627 295 PPPYEAVVGQPPASQVTSIGQQVAESSSGDPNTSAGFSTPVPADSTSLLVSEGTATPGSSPSPDGPvGAPAPSEPALPPG 374
Cdd:PRK07764  610 EEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGG-AAPAAPPPAPAPA 688

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217300627 375 HVSPEDPGMGSQVQPGP------GRVSRSTSDPTLCTSSMAGDASSHRPSCSQDLEAGLSEAVPGSASMSRSATAACRAq 448
Cdd:PRK07764  689 APAAPAGAAPAQPAPAPaatppaGQADDPAAQPPQAAQGASAPSPAADDPVPLPPEPDDPPDPAGAPAQPPPPPAPAPA- 767

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2217300627 449 lSPAGDPDTWKTDQRPTPEPFPATSKERPRSLVDSKAYADA---RVLVAKFLEH 499
Cdd:PRK07764  768 -AAPAAAPPPSPPSEEEEMAEDDAPSMDDEDRRDAEEVAMElleEELGAKKIEE 820
DUF4641 pfam15483
Domain of unknown function (DUF4641); This family of proteins is found in eukaryotes. Proteins ...
 318-374 7.10e-03

Domain of unknown function (DUF4641); This family of proteins is found in eukaryotes. Proteins in this family are typically between 201 and 519 amino acids in length.


Pssm-ID: 464741  Cd Length: 443  Bit Score: 38.96  E-value: 7.10e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2217300627 318 AESSSGDPNTSAGfstPVPADSTSLLVSEGTATP-GSSPSPD--GPVGAPAPSE-PALPPG 374
Cdd:pfam15483 360 GEFSSGDPNIRAP---QVPGNSQPSALSQGGVRPrGPAPSGDqePPVRPPRPERqQQPPPG 417
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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