|
Name |
Accession |
Description |
Interval |
E-value |
| RNA1 super family |
cl34950 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
573-902 |
6.47e-62 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
The actual alignment was detected with superfamily member COG5238:
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 216.58 E-value: 6.47e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217305026 573 ELQHTELARSVEEAMES---GALARLTGPAHRAALAylLQVSDACAQEANLSLSLSQGV---LQSLLPQLLYCRKLRLDT 646
Cdd:COG5238 83 EAFPTQLLVVDWEGAEEvspVALAETATAVATPPPD--LRRIMAKTLEDSLILYLALPRrinLIQVLKDPLGGNAVHLLG 160
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217305026 647 NQFQDPVMELLGSVLSGKDCRIQKISLAENQISNKGAKALARSLLVNRSLTSLDLRGNSIGPQGAKALADALKINRTLTS 726
Cdd:COG5238 161 LAARLGLLAAISMAKALQNNSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSLTT 240
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217305026 727 LSLQGNTVRDDGARSMAEALASNRTLSMLHLQKNSIGPMGAQRMADALKQNRSLKELMFSSNSIGDGGAKALAEALKVNQ 806
Cdd:COG5238 241 LDLSNNQIGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGNK 320
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217305026 807 GLESLDLQSNSISDAGVAALMGALCTNQTLLSLSLRENSISPEGAQAIAHALCANSTLKNLDLTANLLHDQGARAIAVAV 886
Cdd:COG5238 321 TLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEALIDAL 400
|
330
....*....|....*.
gi 2217305026 887 RENRtLTSLHLQWNFI 902
Cdd:COG5238 401 QTNR-LHTLILDGNLI 415
|
|
| NACHT |
pfam05729 |
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ... |
139-305 |
1.49e-44 |
|
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.
:
Pssm-ID: 428606 [Multi-domain] Cd Length: 166 Bit Score: 158.24 E-value: 1.49e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217305026 139 RVSITIGVAGMGKTTLVRHFVRLWAHGQVGKDFSLVLPLTFRDLNTHEK-LCADRLICSVFPHVGEPSLAV-----AVPA 212
Cdd:pfam05729 1 RTVILQGEAGSGKTTLLQKLALLWAQGKLPQGFDFVFFLPCRELSRSGNaRSLADLLFSQWPEPAAPVSEVwavilELPE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217305026 213 RALLILDGLDECRTPLDFSNTvactdpkkEIPVDHLITNIIRGNLFPEVSIWITSRPSASGQIPGGLVD-RMTEIRGFNE 291
Cdd:pfam05729 81 RLLLILDGLDELVSDLGQLDG--------PCPVLTLLSSLLRKKLLPGASLLLTVRPDALRDLRRGLEEpRYLEVRGFSE 152
|
170
....*....|....
gi 2217305026 292 EEIKVCLEQMFPED 305
Cdd:pfam05729 153 SDRKQYVRKYFSDE 166
|
|
| NLRC4_HD2 |
pfam17776 |
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein ... |
455-582 |
9.17e-18 |
|
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein and NOD2 protein.
:
Pssm-ID: 465499 [Multi-domain] Cd Length: 122 Bit Score: 80.03 E-value: 9.17e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217305026 455 HLSLQEFVAAAYYYGASRRAIFDLFTESGVSWPRLGFlthfRSAAQRAMQAEDGRLDVFLRFLSGLLSPRVNALLAGSL- 533
Cdd:pfam17776 1 HLSFQEFFAALFYVLSFKEEKSNPLKEFFGLRKRESL----KSLLDKALKSKNGHLDLFLRFLFGLLNEENQRLLEGLLg 76
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 2217305026 534 --LAQGEHQAYRTQVAELLQGCLRPDaavcaRAINVLHCLHELQHTELARS 582
Cdd:pfam17776 77 ckLSSEIKQELLQWIKSLIQKELSSE-----RFLNLFHCLYELQDESFVKE 122
|
|
| NOD2_WH |
pfam17779 |
NOD2 winged helix domain; This winged helix domain is found in the NOD2 protein. Its molecular ... |
395-453 |
9.08e-11 |
|
NOD2 winged helix domain; This winged helix domain is found in the NOD2 protein. Its molecular function is not known.
:
Pssm-ID: 465501 Cd Length: 57 Bit Score: 57.96 E-value: 9.08e-11
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 2217305026 395 KMVGTLGRLAFHGLLKKKYVFYEQDMKAFGVDLALLQGAPCSCFLQREETLASsvAYCF 453
Cdd:pfam17779 1 KLLLKLGKLAFEGLWKKKLVFSEEDLKEYGLDESDLSSGLLTEILQKDLGCEK--VYSF 57
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
573-902 |
6.47e-62 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 216.58 E-value: 6.47e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217305026 573 ELQHTELARSVEEAMES---GALARLTGPAHRAALAylLQVSDACAQEANLSLSLSQGV---LQSLLPQLLYCRKLRLDT 646
Cdd:COG5238 83 EAFPTQLLVVDWEGAEEvspVALAETATAVATPPPD--LRRIMAKTLEDSLILYLALPRrinLIQVLKDPLGGNAVHLLG 160
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217305026 647 NQFQDPVMELLGSVLSGKDCRIQKISLAENQISNKGAKALARSLLVNRSLTSLDLRGNSIGPQGAKALADALKINRTLTS 726
Cdd:COG5238 161 LAARLGLLAAISMAKALQNNSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSLTT 240
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217305026 727 LSLQGNTVRDDGARSMAEALASNRTLSMLHLQKNSIGPMGAQRMADALKQNRSLKELMFSSNSIGDGGAKALAEALKVNQ 806
Cdd:COG5238 241 LDLSNNQIGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGNK 320
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217305026 807 GLESLDLQSNSISDAGVAALMGALCTNQTLLSLSLRENSISPEGAQAIAHALCANSTLKNLDLTANLLHDQGARAIAVAV 886
Cdd:COG5238 321 TLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEALIDAL 400
|
330
....*....|....*.
gi 2217305026 887 RENRtLTSLHLQWNFI 902
Cdd:COG5238 401 QTNR-LHTLILDGNLI 415
|
|
| NACHT |
pfam05729 |
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ... |
139-305 |
1.49e-44 |
|
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.
Pssm-ID: 428606 [Multi-domain] Cd Length: 166 Bit Score: 158.24 E-value: 1.49e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217305026 139 RVSITIGVAGMGKTTLVRHFVRLWAHGQVGKDFSLVLPLTFRDLNTHEK-LCADRLICSVFPHVGEPSLAV-----AVPA 212
Cdd:pfam05729 1 RTVILQGEAGSGKTTLLQKLALLWAQGKLPQGFDFVFFLPCRELSRSGNaRSLADLLFSQWPEPAAPVSEVwavilELPE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217305026 213 RALLILDGLDECRTPLDFSNTvactdpkkEIPVDHLITNIIRGNLFPEVSIWITSRPSASGQIPGGLVD-RMTEIRGFNE 291
Cdd:pfam05729 81 RLLLILDGLDELVSDLGQLDG--------PCPVLTLLSSLLRKKLLPGASLLLTVRPDALRDLRRGLEEpRYLEVRGFSE 152
|
170
....*....|....
gi 2217305026 292 EEIKVCLEQMFPED 305
Cdd:pfam05729 153 SDRKQYVRKYFSDE 166
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
657-890 |
1.04e-36 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 140.95 E-value: 1.04e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217305026 657 LGSVLSG--KDCRIQKISLAENQISNKGAKALArSLLVNRSLTSLDLRGNSIGPQGAKALADALKINR-TLTSLSLQGNT 733
Cdd:cd00116 70 LQSLLQGltKGCGLQELDLSDNALGPDGCGVLE-SLLRSSSLQELKLNNNGLGDRGLRLLAKGLKDLPpALEKLVLGRNR 148
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217305026 734 VRDDGARSMAEALASNRTLSMLHLQKNSIGPMGAQRMADALKQNRSLKELMFSSNSIGDGGAKALAEALKVNQGLESLDL 813
Cdd:cd00116 149 LEGASCEALAKALRANRDLKELNLANNGIGDAGIRALAEGLKANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNL 228
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2217305026 814 QSNSISDAGVAALMGAL-CTNQTLLSLSLRENSISPEGAQAIAHALCANSTLKNLDLTANLLHDQGARAIAVAVRENR 890
Cdd:cd00116 229 GDNNLTDAGAAALASALlSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGAQLLAESLLEPG 306
|
|
| NLRC4_HD2 |
pfam17776 |
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein ... |
455-582 |
9.17e-18 |
|
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein and NOD2 protein.
Pssm-ID: 465499 [Multi-domain] Cd Length: 122 Bit Score: 80.03 E-value: 9.17e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217305026 455 HLSLQEFVAAAYYYGASRRAIFDLFTESGVSWPRLGFlthfRSAAQRAMQAEDGRLDVFLRFLSGLLSPRVNALLAGSL- 533
Cdd:pfam17776 1 HLSFQEFFAALFYVLSFKEEKSNPLKEFFGLRKRESL----KSLLDKALKSKNGHLDLFLRFLFGLLNEENQRLLEGLLg 76
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 2217305026 534 --LAQGEHQAYRTQVAELLQGCLRPDaavcaRAINVLHCLHELQHTELARS 582
Cdd:pfam17776 77 ckLSSEIKQELLQWIKSLIQKELSSE-----RFLNLFHCLYELQDESFVKE 122
|
|
| NOD2_WH |
pfam17779 |
NOD2 winged helix domain; This winged helix domain is found in the NOD2 protein. Its molecular ... |
395-453 |
9.08e-11 |
|
NOD2 winged helix domain; This winged helix domain is found in the NOD2 protein. Its molecular function is not known.
Pssm-ID: 465501 Cd Length: 57 Bit Score: 57.96 E-value: 9.08e-11
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 2217305026 395 KMVGTLGRLAFHGLLKKKYVFYEQDMKAFGVDLALLQGAPCSCFLQREETLASsvAYCF 453
Cdd:pfam17779 1 KLLLKLGKLAFEGLWKKKLVFSEEDLKEYGLDESDLSSGLLTEILQKDLGCEK--VYSF 57
|
|
| LRR_RI |
smart00368 |
Leucine rich repeat, ribonuclease inhibitor type; |
693-719 |
2.47e-04 |
|
Leucine rich repeat, ribonuclease inhibitor type;
Pssm-ID: 197686 [Multi-domain] Cd Length: 28 Bit Score: 38.93 E-value: 2.47e-04
|
| LRR_6 |
pfam13516 |
Leucine Rich repeat; |
692-715 |
8.58e-04 |
|
Leucine Rich repeat;
Pssm-ID: 463907 [Multi-domain] Cd Length: 24 Bit Score: 37.21 E-value: 8.58e-04
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
573-902 |
6.47e-62 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 216.58 E-value: 6.47e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217305026 573 ELQHTELARSVEEAMES---GALARLTGPAHRAALAylLQVSDACAQEANLSLSLSQGV---LQSLLPQLLYCRKLRLDT 646
Cdd:COG5238 83 EAFPTQLLVVDWEGAEEvspVALAETATAVATPPPD--LRRIMAKTLEDSLILYLALPRrinLIQVLKDPLGGNAVHLLG 160
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217305026 647 NQFQDPVMELLGSVLSGKDCRIQKISLAENQISNKGAKALARSLLVNRSLTSLDLRGNSIGPQGAKALADALKINRTLTS 726
Cdd:COG5238 161 LAARLGLLAAISMAKALQNNSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSLTT 240
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217305026 727 LSLQGNTVRDDGARSMAEALASNRTLSMLHLQKNSIGPMGAQRMADALKQNRSLKELMFSSNSIGDGGAKALAEALKVNQ 806
Cdd:COG5238 241 LDLSNNQIGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGNK 320
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217305026 807 GLESLDLQSNSISDAGVAALMGALCTNQTLLSLSLRENSISPEGAQAIAHALCANSTLKNLDLTANLLHDQGARAIAVAV 886
Cdd:COG5238 321 TLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEALIDAL 400
|
330
....*....|....*.
gi 2217305026 887 RENRtLTSLHLQWNFI 902
Cdd:COG5238 401 QTNR-LHTLILDGNLI 415
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
667-936 |
1.45e-44 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 167.27 E-value: 1.45e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217305026 667 RIQKISLAENQISNKGAKALARSLLVnrsLTSLDLRGNSIGPQGAKALADALKI-NRTLTSLSLQGNTVRDDGARSMAEA 745
Cdd:COG5238 127 LEDSLILYLALPRRINLIQVLKDPLG---GNAVHLLGLAARLGLLAAISMAKALqNNSVETVYLGCNQIGDEGIEELAEA 203
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217305026 746 LASNRTLSMLHLQKNSIGPMGAQRMADALKQNRSLKELMFSSNSIGDGGAKALAEALKVNQGLESLDLQSNSISDAGVAA 825
Cdd:COG5238 204 LTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIA 283
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217305026 826 LMGALCTNQTLLSLSLRENSISPEGAQAIAHALCANSTLKNLDLTANLLHDQGARAIAVAVRENRTLTSLHLQWNFIQAG 905
Cdd:COG5238 284 LAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLSDNQIGDE 363
|
250 260 270
....*....|....*....|....*....|.
gi 2217305026 906 AAQALGQALQLNRSLTSLefHFSIHQLTDVG 936
Cdd:COG5238 364 GAIALAKYLEGNTTLREL--NLGKNNIGKQG 392
|
|
| NACHT |
pfam05729 |
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ... |
139-305 |
1.49e-44 |
|
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.
Pssm-ID: 428606 [Multi-domain] Cd Length: 166 Bit Score: 158.24 E-value: 1.49e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217305026 139 RVSITIGVAGMGKTTLVRHFVRLWAHGQVGKDFSLVLPLTFRDLNTHEK-LCADRLICSVFPHVGEPSLAV-----AVPA 212
Cdd:pfam05729 1 RTVILQGEAGSGKTTLLQKLALLWAQGKLPQGFDFVFFLPCRELSRSGNaRSLADLLFSQWPEPAAPVSEVwavilELPE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217305026 213 RALLILDGLDECRTPLDFSNTvactdpkkEIPVDHLITNIIRGNLFPEVSIWITSRPSASGQIPGGLVD-RMTEIRGFNE 291
Cdd:pfam05729 81 RLLLILDGLDELVSDLGQLDG--------PCPVLTLLSSLLRKKLLPGASLLLTVRPDALRDLRRGLEEpRYLEVRGFSE 152
|
170
....*....|....
gi 2217305026 292 EEIKVCLEQMFPED 305
Cdd:pfam05729 153 SDRKQYVRKYFSDE 166
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
657-890 |
1.04e-36 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 140.95 E-value: 1.04e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217305026 657 LGSVLSG--KDCRIQKISLAENQISNKGAKALArSLLVNRSLTSLDLRGNSIGPQGAKALADALKINR-TLTSLSLQGNT 733
Cdd:cd00116 70 LQSLLQGltKGCGLQELDLSDNALGPDGCGVLE-SLLRSSSLQELKLNNNGLGDRGLRLLAKGLKDLPpALEKLVLGRNR 148
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217305026 734 VRDDGARSMAEALASNRTLSMLHLQKNSIGPMGAQRMADALKQNRSLKELMFSSNSIGDGGAKALAEALKVNQGLESLDL 813
Cdd:cd00116 149 LEGASCEALAKALRANRDLKELNLANNGIGDAGIRALAEGLKANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNL 228
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2217305026 814 QSNSISDAGVAALMGAL-CTNQTLLSLSLRENSISPEGAQAIAHALCANSTLKNLDLTANLLHDQGARAIAVAVRENR 890
Cdd:cd00116 229 GDNNLTDAGAAALASALlSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGAQLLAESLLEPG 306
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
615-862 |
8.10e-35 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 135.56 E-value: 8.10e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217305026 615 AQEANLSLSLSQG---VLQSLLPQLLYC---RKLRLDTNQFQDPVMELLGSVLSGKDcrIQKISLAENQISNKGAKALAR 688
Cdd:cd00116 53 LKELCLSLNETGRiprGLQSLLQGLTKGcglQELDLSDNALGPDGCGVLESLLRSSS--LQELKLNNNGLGDRGLRLLAK 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217305026 689 SLL-VNRSLTSLDLRGNSIGPQGAKALADALKINRTLTSLSLQGNTVRDDGARSMAEALASNRTLSMLHLQKNSIGPMGA 767
Cdd:cd00116 131 GLKdLPPALEKLVLGRNRLEGASCEALAKALRANRDLKELNLANNGIGDAGIRALAEGLKANCNLEVLDLNNNGLTDEGA 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217305026 768 QRMADALKQNRSLKELMFSSNSIGDGGAKALAEALK-VNQGLESLDLQSNSISDAGVAALMGALCTNQTLLSLSLRENSI 846
Cdd:cd00116 211 SALAETLASLKSLEVLNLGDNNLTDAGAAALASALLsPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKF 290
|
250
....*....|....*.
gi 2217305026 847 SPEGAQAIAHALCANS 862
Cdd:cd00116 291 GEEGAQLLAESLLEPG 306
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
622-900 |
1.80e-34 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 134.41 E-value: 1.80e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217305026 622 LSLSQGVLQSLLPQLLYCRKLRLDTNQFQDPVMELLGSVL-SGKDCRIQKISLAENQISNKGAKALARSLLVNRSLTSLD 700
Cdd:cd00116 8 ELLKTERATELLPKLLCLQVLRLEGNTLGEEAAKALASALrPQPSLKELCLSLNETGRIPRGLQSLLQGLTKGCGLQELD 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217305026 701 LRGNSIGPQGAKALADALKiNRTLTSLSLQGNTVRDDGARSMAEALASNR-TLSMLHLQKNSIGPMGAQRMADALKQNRS 779
Cdd:cd00116 88 LSDNALGPDGCGVLESLLR-SSSLQELKLNNNGLGDRGLRLLAKGLKDLPpALEKLVLGRNRLEGASCEALAKALRANRD 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217305026 780 LKELMFSSNSIGDGGAKALAEALKVNQGLESLDLQSNSISDAGVAALMGALCTNQTLLSLSLRENSISPEGAQAIAHALC 859
Cdd:cd00116 167 LKELNLANNGIGDAGIRALAEGLKANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDAGAAALASALL 246
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 2217305026 860 A-NSTLKNLDLTANLLHDQGARAIAVAVRENRTLTSLHLQWN 900
Cdd:cd00116 247 SpNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGN 288
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
634-902 |
4.60e-33 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 130.55 E-value: 4.60e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217305026 634 PQLLYCRKL--RLDTNQFQDPVMELlgsvlsgkdcriQKISLAENQISNKGAKALARSLLVNRSLTSLDLRGNSIG--PQ 709
Cdd:cd00116 1 LQLSLKGELlkTERATELLPKLLCL------------QVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETGriPR 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217305026 710 GAKALADALKINRTLTSLSLQGNTVRDDGARSMaEALASNRTLSMLHLQKNSIGPMGAQRMADALKQNR-SLKELMFSSN 788
Cdd:cd00116 69 GLQSLLQGLTKGCGLQELDLSDNALGPDGCGVL-ESLLRSSSLQELKLNNNGLGDRGLRLLAKGLKDLPpALEKLVLGRN 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217305026 789 SIGDGGAKALAEALKVNQGLESLDLQSNSISDAGVAALMGALCTNQTLLSLSLRENSISPEGAQAIAHALCANSTLKNLD 868
Cdd:cd00116 148 RLEGASCEALAKALRANRDLKELNLANNGIGDAGIRALAEGLKANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLN 227
|
250 260 270
....*....|....*....|....*....|....*
gi 2217305026 869 LTANLLHDQGARAIAVAVR-ENRTLTSLHLQWNFI 902
Cdd:cd00116 228 LGDNNLTDAGAAALASALLsPNISLLTLSLSCNDI 262
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
622-818 |
8.30e-24 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 103.20 E-value: 8.30e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217305026 622 LSLSQGVLQSLLPQLlycRKLRLDTNQFQDPVMELLGSVLSgKDCRIQKISLAENQISNKGAKALARSLLVNRSLTSLDL 701
Cdd:cd00116 125 LRLLAKGLKDLPPAL---EKLVLGRNRLEGASCEALAKALR-ANRDLKELNLANNGIGDAGIRALAEGLKANCNLEVLDL 200
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217305026 702 RGNSIGPQGAKALADALKINRTLTSLSLQGNTVRDDGARSMAEALAS-NRTLSMLHLQKNSIGPMGAQRMADALKQNRSL 780
Cdd:cd00116 201 NNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDAGAAALASALLSpNISLLTLSLSCNDITDDGAKDLAEVLAEKESL 280
|
170 180 190
....*....|....*....|....*....|....*....
gi 2217305026 781 KELMFSSNSIGDGGAKALAEALKVNQG-LESLDLQSNSI 818
Cdd:cd00116 281 LELDLRGNKFGEEGAQLLAESLLEPGNeLESLWVKDDSF 319
|
|
| NLRC4_HD2 |
pfam17776 |
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein ... |
455-582 |
9.17e-18 |
|
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein and NOD2 protein.
Pssm-ID: 465499 [Multi-domain] Cd Length: 122 Bit Score: 80.03 E-value: 9.17e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217305026 455 HLSLQEFVAAAYYYGASRRAIFDLFTESGVSWPRLGFlthfRSAAQRAMQAEDGRLDVFLRFLSGLLSPRVNALLAGSL- 533
Cdd:pfam17776 1 HLSFQEFFAALFYVLSFKEEKSNPLKEFFGLRKRESL----KSLLDKALKSKNGHLDLFLRFLFGLLNEENQRLLEGLLg 76
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 2217305026 534 --LAQGEHQAYRTQVAELLQGCLRPDaavcaRAINVLHCLHELQHTELARS 582
Cdd:pfam17776 77 ckLSSEIKQELLQWIKSLIQKELSSE-----RFLNLFHCLYELQDESFVKE 122
|
|
| NACHT |
COG5635 |
Predicted NTPase, NACHT family domain [Signal transduction mechanisms]; |
144-941 |
9.97e-18 |
|
Predicted NTPase, NACHT family domain [Signal transduction mechanisms];
Pssm-ID: 444362 [Multi-domain] Cd Length: 935 Bit Score: 88.71 E-value: 9.97e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217305026 144 IGVAGMGKTTLVRHFVRLWAHGQVGKDFSLVLPLTFRDLNTHEKLcaDRLICSVFPHVGEPS----LAVAVPARALLILD 219
Cdd:COG5635 186 LGEPGSGKTTLLRYLALELAERYLDAEDPIPILIELRDLAEEASL--EDLLAEALEKRGGEPedalERLLRNGRLLLLLD 263
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217305026 220 GLDECRTPLDFSNTVactdpkkeipvdHLITNIIRGnlFPEVSIWITSRPSASGQIPGGLVDRMtEIRGFNEEEIKVCLE 299
Cdd:COG5635 264 GLDEVPDEADRDEVL------------NQLRRFLER--YPKARVIITSRPEGYDSSELEGFEVL-ELAPLSDEQIEEFLK 328
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217305026 300 QMFPEDQALLGWMLSQVQADRALYLMCTVPAFCRLtgmaLGHLWRSRtgpqdAELwpPRTLCELYSWYFRMALSGEGQEK 379
Cdd:COG5635 329 KWFEATERKAERLLEALEENPELRELARNPLLLTL----LALLLRER-----GEL--PDTRAELYEQFVELLLERWDEQR 397
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217305026 380 GKASPRIEQVAHggRKMVgtLGRLAFHGLLKKKYVFYEQDMKAF---------GVDLALLQGAPCSCFLQREetlaSSVA 450
Cdd:COG5635 398 GLTIYRELSREE--LREL--LSELALAMQENGRTEFAREELEEIlreylgrrkDAEALLDELLLRTGLLVER----GEGR 469
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217305026 451 YCFTHLSLQEFVAAAYYYGASRRAIFDLFTEsgvswprlgflthfrsaaqramQAEDGRLDVFLRFLSGLLSPrvnalla 530
Cdd:COG5635 470 YSFAHRSFQEYLAARALVEELDEELLELLAE----------------------HLEDPRWREVLLLLAGLLDD------- 520
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217305026 531 gsllaqgehqayRTQVAELLQGCLRPDAAVCARAINVLHCLHELQHTELARSVEEAMESGALARLTGPAHRAALAYLLQV 610
Cdd:COG5635 521 ------------VKQIKELIDALLARDDAAALALAAALLLALLLALALLALLALLLLLRLLLALLALLLLALLLLLLLAL 588
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217305026 611 SDACAQEANLSLSLSQGVLQSLLPQLLycRKLRLDTNQFQDPVMELLGSVLSGKDCRIQKISLAENQISNKGAKALARSL 690
Cdd:COG5635 589 LLALLALDLGLAALLLLLLLLLLLLLL--LALALLLALLLLLLLLLLAELLLLALLALVLLSLLLASRLLLITLLLLAAA 666
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217305026 691 LVNRSLTSLDLRGNSIGPQGAKALADALKINRTLTSLSLQGNTVRDDGARSMAEALASNRTLSMLHLqknsigpmgAQRM 770
Cdd:COG5635 667 SAALLLLLLLLLAELLLALLALASLLLLLLLALALALALLLLAVLLAAALDLLLLLVLLLALLLVLA---------LALS 737
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217305026 771 ADALKQNRSLKELMFSSNSIGDGGAKALAEALKVNQGLESLDLQSNSISDAGVAALMGALCTNQTLLSLSLRENSISPEG 850
Cdd:COG5635 738 LLLLALALLLAGALLLESSALLAVLLASLLLALLLLSLLLLLVLLLALALLASLLLALLLLILLLVLLGSLLLLRLLDDL 817
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217305026 851 AQAIAHALCANSTLKN--LDLTANLLHDQGARAIAVAVRENRTLTSLHLQWNFIQAGAAQALGQALQLNRSLTSLEFHFS 928
Cdd:COG5635 818 ALLLLLALAAARLLLSslALVALELARASLGASLVLLALLLATLLLLLLLLLALALALLSLLSLSSLALLSLLGLLLALS 897
|
810
....*....|...
gi 2217305026 929 IHQLTDVGLFLLG 941
Cdd:COG5635 898 LLALLLLSLSLAL 910
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
621-928 |
1.82e-12 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 70.35 E-value: 1.82e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217305026 621 SLSLSQGVLQSL---LPQLLYCRKLRLDTNQFQDpvmelLGSVLSGKDcRIQKISLAENQISNkgakaLARSLLVNRSLT 697
Cdd:COG4886 117 SLDLSGNQLTDLpeeLANLTNLKELDLSNNQLTD-----LPEPLGNLT-NLKSLDLSNNQLTD-----LPEELGNLTNLK 185
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217305026 698 SLDLRGNSIgpqgaKALADALKINRTLTSLSLQGNTVRDdgarsMAEALASNRTLSMLHLQKNSIGPMgaqrmaDALKQN 777
Cdd:COG4886 186 ELDLSNNQI-----TDLPEPLGNLTNLEELDLSGNQLTD-----LPEPLANLTNLETLDLSNNQLTDL------PELGNL 249
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217305026 778 RSLKELMFSSNSIGDggakaLAEALKvNQGLESLDLQSNSISDAGVAALMGALCTNQTLLSLSLRENSISPEGAQAIAHA 857
Cdd:COG4886 250 TNLEELDLSNNQLTD-----LPPLAN-LTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTL 323
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2217305026 858 LCANSTLKNLDLTANLLHDQGARAIAVAVRENRTLTSLHLQWNFIQAGAAQALGQALQLNRSLTSLEFHFS 928
Cdd:COG4886 324 LLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLL 394
|
|
| NOD2_WH |
pfam17779 |
NOD2 winged helix domain; This winged helix domain is found in the NOD2 protein. Its molecular ... |
395-453 |
9.08e-11 |
|
NOD2 winged helix domain; This winged helix domain is found in the NOD2 protein. Its molecular function is not known.
Pssm-ID: 465501 Cd Length: 57 Bit Score: 57.96 E-value: 9.08e-11
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 2217305026 395 KMVGTLGRLAFHGLLKKKYVFYEQDMKAFGVDLALLQGAPCSCFLQREETLASsvAYCF 453
Cdd:pfam17779 1 KLLLKLGKLAFEGLWKKKLVFSEEDLKEYGLDESDLSSGLLTEILQKDLGCEK--VYSF 57
|
|
| LRR_RI |
smart00368 |
Leucine rich repeat, ribonuclease inhibitor type; |
693-719 |
2.47e-04 |
|
Leucine rich repeat, ribonuclease inhibitor type;
Pssm-ID: 197686 [Multi-domain] Cd Length: 28 Bit Score: 38.93 E-value: 2.47e-04
|
| LRR_6 |
pfam13516 |
Leucine Rich repeat; |
692-715 |
8.58e-04 |
|
Leucine Rich repeat;
Pssm-ID: 463907 [Multi-domain] Cd Length: 24 Bit Score: 37.21 E-value: 8.58e-04
|
| LRR_RI |
smart00368 |
Leucine rich repeat, ribonuclease inhibitor type; |
777-803 |
1.07e-03 |
|
Leucine rich repeat, ribonuclease inhibitor type;
Pssm-ID: 197686 [Multi-domain] Cd Length: 28 Bit Score: 37.00 E-value: 1.07e-03
|
| LRR_RI |
smart00368 |
Leucine rich repeat, ribonuclease inhibitor type; |
721-748 |
6.08e-03 |
|
Leucine rich repeat, ribonuclease inhibitor type;
Pssm-ID: 197686 [Multi-domain] Cd Length: 28 Bit Score: 35.08 E-value: 6.08e-03
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
676-902 |
9.18e-03 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 39.53 E-value: 9.18e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217305026 676 NQISNKGAKALARSLLVNRSLTSLDLRGNSIGPQGAKALADALKINRTLTSLSLQGNTVRDDGARSMAEALASNRTLSML 755
Cdd:COG4886 1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217305026 756 HLQKNSIGPmgaqrmaDALKQNRSLKELMFSSNsigdggakalaEALKVNQGLESLDLQSNSISDagvaaLMGALCTNQT 835
Cdd:COG4886 81 LLSLLLLGL-------TDLGDLTNLTELDLSGN-----------EELSNLTNLESLDLSGNQLTD-----LPEELANLTN 137
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2217305026 836 LLSLSLRENSISpegaqAIAHALCANSTLKNLDLTANLLHDqgaraIAVAVRENRTLTSLHLQWNFI 902
Cdd:COG4886 138 LKELDLSNNQLT-----DLPEPLGNLTNLKSLDLSNNQLTD-----LPEELGNLTNLKELDLSNNQI 194
|
|
| |
