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Conserved domains on  [gi|2217309485|ref|XP_047291127|]
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stAR-related lipid transfer protein 3 isoform X8 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MENTAL super family cl11103
Cholesterol-capturing domain; Human meta-static lymph node (MLN) 64 is a late endosomal ...
 47-121 5.33e-40

Cholesterol-capturing domain; Human meta-static lymph node (MLN) 64 is a late endosomal membrane protein, and carries this MENTAL (MLN64N-terminal) domain at its N-terminus. The domain is composed of four trans-membrane helices with three short intervening loops. The function of the domain is to capture cholesterol and pass it to the associated START domain pfam01852 for transfer to a cytosolic acceptor protein or membrane. In mammals, the MENTAL domain is involved in the localization of MLN64 and MENTHO in late endosomes, and also in homo-and of hetero-interactions of these two proteins.


The actual alignment was detected with superfamily member pfam10457:

Pssm-ID: 463097  Cd Length: 177  Bit Score: 136.65  E-value: 5.33e-40
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2217309485  47 SDVRRTFCLFVTFDLLFISLLWIIELNTN-TGIRKNLEQEIIQYNFKTSFFDIFVLAFFRFSGLLLGYAVLRLRHW 121
Cdd:pfam10457   1 SDVRRFFCLFVTFDLLFTSLLWLICLVINgENIKKAFEKEVLHYNIKTSLFDIVLLAAFRFLVLLLFYALLRLNHW 76
 
Name Accession Description Interval E-value
MENTAL pfam10457
Cholesterol-capturing domain; Human meta-static lymph node (MLN) 64 is a late endosomal ...
 47-121 5.33e-40

Cholesterol-capturing domain; Human meta-static lymph node (MLN) 64 is a late endosomal membrane protein, and carries this MENTAL (MLN64N-terminal) domain at its N-terminus. The domain is composed of four trans-membrane helices with three short intervening loops. The function of the domain is to capture cholesterol and pass it to the associated START domain pfam01852 for transfer to a cytosolic acceptor protein or membrane. In mammals, the MENTAL domain is involved in the localization of MLN64 and MENTHO in late endosomes, and also in homo-and of hetero-interactions of these two proteins.


Pssm-ID: 463097  Cd Length: 177  Bit Score: 136.65  E-value: 5.33e-40
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2217309485  47 SDVRRTFCLFVTFDLLFISLLWIIELNTN-TGIRKNLEQEIIQYNFKTSFFDIFVLAFFRFSGLLLGYAVLRLRHW 121
Cdd:pfam10457   1 SDVRRFFCLFVTFDLLFTSLLWLICLVINgENIKKAFEKEVLHYNIKTSLFDIVLLAAFRFLVLLLFYALLRLNHW 76
 
Name Accession Description Interval E-value
MENTAL pfam10457
Cholesterol-capturing domain; Human meta-static lymph node (MLN) 64 is a late endosomal ...
 47-121 5.33e-40

Cholesterol-capturing domain; Human meta-static lymph node (MLN) 64 is a late endosomal membrane protein, and carries this MENTAL (MLN64N-terminal) domain at its N-terminus. The domain is composed of four trans-membrane helices with three short intervening loops. The function of the domain is to capture cholesterol and pass it to the associated START domain pfam01852 for transfer to a cytosolic acceptor protein or membrane. In mammals, the MENTAL domain is involved in the localization of MLN64 and MENTHO in late endosomes, and also in homo-and of hetero-interactions of these two proteins.


Pssm-ID: 463097  Cd Length: 177  Bit Score: 136.65  E-value: 5.33e-40
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2217309485  47 SDVRRTFCLFVTFDLLFISLLWIIELNTN-TGIRKNLEQEIIQYNFKTSFFDIFVLAFFRFSGLLLGYAVLRLRHW 121
Cdd:pfam10457   1 SDVRRFFCLFVTFDLLFTSLLWLICLVINgENIKKAFEKEVLHYNIKTSLFDIVLLAAFRFLVLLLFYALLRLNHW 76
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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