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Conserved domains on  [gi|2217311592|ref|XP_047291884|]
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integrin beta-4 isoform X9 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
INB smart00187
Integrin beta subunits (N-terminal portion of extracellular region); Portion of beta integrins ...
 72-488 0e+00

Integrin beta subunits (N-terminal portion of extracellular region); Portion of beta integrins that lies N-terminal to their EGF-like repeats. Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Beta integrins are proposed to have a von Willebrand factor type-A "insert" or "I" -like domain (although this remains to be confirmed).


:

Pssm-ID: 197563 [Multi-domain]  Cd Length: 423  Bit Score: 614.71  E-value: 0e+00
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311592    72 SCTECVRVDKDCAYCTDEMFRDR---RCNTQAELLAAGCQRESIVVMESSFQITEETQID---TTLRRSQMSPQGLRVRL 145
Cdd:smart00187    1 SCEECIQSGPNCAWCTDENFTSGgsaRCDTRANLLAKGCSPESIENPASSAEVLEDKPLSdkgSGGQAVQVSPQRVRLKL 80

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311592   146 RPGEERHFELEVFEPLESPVDLYILMDFSNSMSDDLDNLKKMGQNLARVLSQLTSDYTIGFGKFVDKVSVPQTDMRPEKL 225
Cdd:smart00187   81 RPGEPQNFTLTVRQAEDYPVDLYYLMDLSYSMKDDLDNLKSLGDDLAREMKGLTSNFRLGFGSFVDKTVSPFVSTHPEKL 160

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311592   226 KEPWPN----SDPPFSFKNVISLTEDVDEFRNKLQGERISGNLDAPEGGFDAILQTAVCTRDIGWRPDSTHLLVFSTESA 301
Cdd:smart00187  161 ENPCPNynktCEPPYGFKHVLSLTDDTDEFNEEVGKQRISGNLDAPEGGFDAIMQAAVCTEQIGWREDARRLLVFSTDAG 240

                           250       260       270       280       290       300       310       320
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311592   302 FHYEADGAnvLAGIMSRNDERCHLDTTGTYTQYRTQDYPSVPTLVRLLAKHNIIPIFAVTNYSYSYYEKLHTYFPVSSLG 381
Cdd:smart00187  241 FHFAGDGK--LGGIVTPNDGQCHLDNNGEYTMSTTQDYPSIGQLAQKLAENNINPIFAVTKKQVSLYKELSALIPGSSVG 318

                           330       340       350       360       370       380       390       400
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311592   382 VLQEDSSNIVELLEEAFNRIRSNLDIRALDSPRGLRTEVTSkMFQKTRTGSFHirRGEVGIYQVQLRALEHVDGTHVCQl 461
Cdd:smart00187  319 ELSEDSSNVVELIKDAYNKISSRVELEDNALPEGVSVTYTS-SCPGGVTGPGT--RKCEGVKIGDTVSFEVTVTATKCP- 394

                           410       420
                    ....*....|....*....|....*...
gi 2217311592   462 PEDQKGNIHLKP-SFSDGLKMDAGIICD 488
Cdd:smart00187  395 PEDQEQSIRIRPvGFSETLEVEVTFLCD 422
Integrin_B_tail pfam07965
Integrin beta tail domain; This is the beta tail domain of the Integrin protein. Integrins are ...
 661-744 5.32e-27

Integrin beta tail domain; This is the beta tail domain of the Integrin protein. Integrins are receptors which are involved in cell-cell and cell-extracellular matrix interactions.


:

Pssm-ID: 462325  Cd Length: 84  Bit Score: 105.82  E-value: 5.32e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311592  661 CEDLRSCVQCQAWGTGEKKGRTC-EECNFKVKMVDELKRAEE-VVVRCSFRDEdDDCTYSYTMEGDgaPGPNSTVLVHKK 738
Cdd:pfam07965    1 CEEKKSCVECQAFKTGPLKEKNCsRNCKFEIILVEVLKEDEEpGAVLCSFKDE-DDCWFTFTYYED--ESGKYVVHVQKE 77


                   ....*.
gi 2217311592  739 KDCPPG 744
Cdd:pfam07965   78 RECPPG 83
Calx-beta pfam03160
Calx-beta domain;
1025-1119 3.36e-25

Calx-beta domain;


:

Pssm-ID: 397326 [Multi-domain]  Cd Length: 91  Bit Score: 101.17  E-value: 3.36e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311592 1025 DVVSFEQPEFSVSRGDQVARIPVIRRVLD-GGKSQVSYRTQDGTAQGNRDYIPVEGELLFQPGEAWKELQVKLLElqevD 1103
Cdd:pfam03160    2 GVIGFEPPTYQVSENDGVAEVCVVRMSGTlRRTVVVPYRTEDGTATAGDDYEPVEGELVFGPGETEKCINVTIID----D 77

                           90
                   ....*....|....*.
gi 2217311592 1104 SLLRGRqvRRFHVQLS 1119
Cdd:pfam03160   78 DVYEGD--ENFFVLLS 91
fn3 pfam00041
Fibronectin type III domain;
1557-1642 2.39e-21

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 89.78  E-value: 2.39e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311592 1557 SAPGPLVFTALSPDSLQLSWERPRRPNGDIVGYLVTCEMAQGGGPATAFRVDGDspESRLTVPGLSENVPYKFKVQARTT 1636
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGEPWNEITVPGT--TTSVTLTGLKPGTEYEVRVQAVNG 78


                   ....*.
gi 2217311592 1637 EGFGPE 1642
Cdd:pfam00041   79 GGEGPP 84
fn3 pfam00041
Fibronectin type III domain;
1163-1243 5.94e-16

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 74.37  E-value: 5.94e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311592 1163 GAPQNPNAKAAGSRKIHFNWLPP---SGKPMGYRVKYWIQGDSESEAHLLDSKVP-SVELTNLYPYCDYEMKVCAYGAQG 1238
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGEPWNEITVPGTTtSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....*
gi 2217311592 1239 EGPYS 1243
Cdd:pfam00041   81 EGPPS 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1255-1348 2.59e-14

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 70.22  E-value: 2.59e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311592 1255 PSEPGRLAFNVVSSTVTQLSWAEPAETNGEITAYEVCYGLVNDDNrpigpMKKVLVDNPKNRMLLIENLRESQPYRYTVK 1334
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGD-----WKEVEVTPGSETSYTLTGLKPGTEYEFRVR 75

                           90
                   ....*....|....
gi 2217311592 1335 ARNGAGWGPEREAI 1348
Cdd:cd00063     76 AVNGGGESPPSESV 89
I-EGF_1 pfam18372
Integrin beta epidermal growth factor like domain 1; This is the I-EGF 1 domain found in ...
 492-520 2.09e-10

Integrin beta epidermal growth factor like domain 1; This is the I-EGF 1 domain found in several integrin betas such as integrin beta 1-7. Structural analysis reveal an epidermal growth factor-like (I-EGF) domains 1 and 2. EGF1 lacks one disulfide (C2-C4) relative to the integrin EGF 2, 3, and 4 domains, this allows the C-terminal end of EGF1 to flex remarkably relative to its N-terminal end.


:

Pssm-ID: 465729  Cd Length: 29  Bit Score: 57.11  E-value: 2.09e-10
                           10        20
                   ....*....|....*....|....*....
gi 2217311592  492 CELQKEVRSARCSFNGDFVCGQCVCSEGW 520
Cdd:pfam18372    1 CEKQAEPNSPRCSGNGTFVCGVCVCNPGY 29
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1483-1524 4.96e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 46.72  E-value: 4.96e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2217311592 1483 SHGELHRLNIPNPAQTSVVVEDLLPNHSYVFRVRAQSQEGWG 1524
Cdd:cd00063     42 GSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGES 83
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 585-608 1.55e-03

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


:

Pssm-ID: 400365  Cd Length: 26  Bit Score: 37.33  E-value: 1.55e-03
                           10        20
                   ....*....|....*....|....*.
gi 2217311592  585 LCNDRGRCSM--GQCVCEPGWTGPSC 608
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
 
Name Accession Description Interval E-value
INB smart00187
Integrin beta subunits (N-terminal portion of extracellular region); Portion of beta integrins ...
 72-488 0e+00

Integrin beta subunits (N-terminal portion of extracellular region); Portion of beta integrins that lies N-terminal to their EGF-like repeats. Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Beta integrins are proposed to have a von Willebrand factor type-A "insert" or "I" -like domain (although this remains to be confirmed).


Pssm-ID: 197563 [Multi-domain]  Cd Length: 423  Bit Score: 614.71  E-value: 0e+00
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311592    72 SCTECVRVDKDCAYCTDEMFRDR---RCNTQAELLAAGCQRESIVVMESSFQITEETQID---TTLRRSQMSPQGLRVRL 145
Cdd:smart00187    1 SCEECIQSGPNCAWCTDENFTSGgsaRCDTRANLLAKGCSPESIENPASSAEVLEDKPLSdkgSGGQAVQVSPQRVRLKL 80

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311592   146 RPGEERHFELEVFEPLESPVDLYILMDFSNSMSDDLDNLKKMGQNLARVLSQLTSDYTIGFGKFVDKVSVPQTDMRPEKL 225
Cdd:smart00187   81 RPGEPQNFTLTVRQAEDYPVDLYYLMDLSYSMKDDLDNLKSLGDDLAREMKGLTSNFRLGFGSFVDKTVSPFVSTHPEKL 160

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311592   226 KEPWPN----SDPPFSFKNVISLTEDVDEFRNKLQGERISGNLDAPEGGFDAILQTAVCTRDIGWRPDSTHLLVFSTESA 301
Cdd:smart00187  161 ENPCPNynktCEPPYGFKHVLSLTDDTDEFNEEVGKQRISGNLDAPEGGFDAIMQAAVCTEQIGWREDARRLLVFSTDAG 240

                           250       260       270       280       290       300       310       320
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311592   302 FHYEADGAnvLAGIMSRNDERCHLDTTGTYTQYRTQDYPSVPTLVRLLAKHNIIPIFAVTNYSYSYYEKLHTYFPVSSLG 381
Cdd:smart00187  241 FHFAGDGK--LGGIVTPNDGQCHLDNNGEYTMSTTQDYPSIGQLAQKLAENNINPIFAVTKKQVSLYKELSALIPGSSVG 318

                           330       340       350       360       370       380       390       400
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311592   382 VLQEDSSNIVELLEEAFNRIRSNLDIRALDSPRGLRTEVTSkMFQKTRTGSFHirRGEVGIYQVQLRALEHVDGTHVCQl 461
Cdd:smart00187  319 ELSEDSSNVVELIKDAYNKISSRVELEDNALPEGVSVTYTS-SCPGGVTGPGT--RKCEGVKIGDTVSFEVTVTATKCP- 394

                           410       420
                    ....*....|....*....|....*...
gi 2217311592   462 PEDQKGNIHLKP-SFSDGLKMDAGIICD 488
Cdd:smart00187  395 PEDQEQSIRIRPvGFSETLEVEVTFLCD 422
Integrin_beta pfam00362
Integrin beta chain VWA domain; Integrins have been found in animals and their homologs have ...
 160-405 7.80e-150

Integrin beta chain VWA domain; Integrins have been found in animals and their homologs have also been found in cyanobacteria, probably due to horizontal gene transfer. This domain corresponds to the integrin beta VWA domain.


Pssm-ID: 459781  Cd Length: 248  Bit Score: 459.27  E-value: 7.80e-150
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311592  160 PLESPVDLYILMDFSNSMSDDLDNLKKMGQNLARVLSQLTSDYTIGFGKFVDKVSVPQTDMRPEKLKEPWPNS----DPP 235
Cdd:pfam00362    1 AEDYPVDLYYLMDLSYSMKDDLDNLKKLGNDLAEEMRNITSNFRLGFGSFVDKPVMPYISTRPEKLKNPCPGEneqcDPP 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311592  236 FSFKNVISLTEDVDEFRNKLQGERISGNLDAPEGGFDAILQTAVCTRDIGWRPDSTHLLVFSTESAFHYEADGAnvLAGI 315
Cdd:pfam00362   81 FGFRHVLSLTNDIEEFTEEVQKQRISGNLDAPEGGFDAIMQAAVCKDQIGWRNEARRLLVFSTDAGFHYAGDGK--LAGI 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311592  316 MSRNDERCHLDTTGTYTQYRTQDYPSVPTLVRLLAKHNIIPIFAVTNYSYSYYEKLHTYFPVSSLGVLQEDSSNIVELLE 395
Cdd:pfam00362  159 VTPNDGQCHLDSNGEYTKSTEQDYPSLGQLVRKLSENNINPIFAVTEEQYSLYEKLSKLIPGSSVGVLSEDSSNIVQLIK 238

                          250
                   ....*....|
gi 2217311592  396 EAFNRIRSNL 405
Cdd:pfam00362  239 EAYEKIRSKV 248
Integrin_B_tail pfam07965
Integrin beta tail domain; This is the beta tail domain of the Integrin protein. Integrins are ...
 661-744 5.32e-27

Integrin beta tail domain; This is the beta tail domain of the Integrin protein. Integrins are receptors which are involved in cell-cell and cell-extracellular matrix interactions.


Pssm-ID: 462325  Cd Length: 84  Bit Score: 105.82  E-value: 5.32e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311592  661 CEDLRSCVQCQAWGTGEKKGRTC-EECNFKVKMVDELKRAEE-VVVRCSFRDEdDDCTYSYTMEGDgaPGPNSTVLVHKK 738
Cdd:pfam07965    1 CEEKKSCVECQAFKTGPLKEKNCsRNCKFEIILVEVLKEDEEpGAVLCSFKDE-DDCWFTFTYYED--ESGKYVVHVQKE 77


                   ....*.
gi 2217311592  739 KDCPPG 744
Cdd:pfam07965   78 RECPPG 83
Calx-beta pfam03160
Calx-beta domain;
1025-1119 3.36e-25

Calx-beta domain;


Pssm-ID: 397326 [Multi-domain]  Cd Length: 91  Bit Score: 101.17  E-value: 3.36e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311592 1025 DVVSFEQPEFSVSRGDQVARIPVIRRVLD-GGKSQVSYRTQDGTAQGNRDYIPVEGELLFQPGEAWKELQVKLLElqevD 1103
Cdd:pfam03160    2 GVIGFEPPTYQVSENDGVAEVCVVRMSGTlRRTVVVPYRTEDGTATAGDDYEPVEGELVFGPGETEKCINVTIID----D 77

                           90
                   ....*....|....*.
gi 2217311592 1104 SLLRGRqvRRFHVQLS 1119
Cdd:pfam03160   78 DVYEGD--ENFFVLLS 91
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 1026-1119 2.69e-23

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 95.40  E-value: 2.69e-23
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311592  1026 VVSFEQPEFSVSRGDQVARIPVIRRVLDGGKSQVSYRTQDGTAQGNRDYIPVEGELLFQPGEAWKELQVKLLelqeVDSL 1105
Cdd:smart00237    3 SVGFEQPVYTVSESDGEVEVCVVRTGGARGPVVVPYSTEDGTATAGSDYEPVPGELTFPPGETEKEIRIKII----DDDI 78

                            90
                    ....*....|....
gi 2217311592  1106 LRGrqVRRFHVQLS 1119
Cdd:smart00237   79 YEK--DETFYVRLS 90
fn3 pfam00041
Fibronectin type III domain;
1557-1642 2.39e-21

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 89.78  E-value: 2.39e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311592 1557 SAPGPLVFTALSPDSLQLSWERPRRPNGDIVGYLVTCEMAQGGGPATAFRVDGDspESRLTVPGLSENVPYKFKVQARTT 1636
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGEPWNEITVPGT--TTSVTLTGLKPGTEYEVRVQAVNG 78


                   ....*.
gi 2217311592 1637 EGFGPE 1642
Cdd:pfam00041   79 GGEGPP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1556-1641 2.55e-17

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 78.69  E-value: 2.55e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311592 1556 PSAPGPLVFTALSPDSLQLSWERPRRPNGDIVGYLVTCEMAQGGGPATAFRVDGDspESRLTVPGLSENVPYKFKVQART 1635
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVTPGS--ETSYTLTGLKPGTEYEFRVRAVN 78


                   ....*.
gi 2217311592 1636 TEGFGP 1641
Cdd:cd00063     79 GGGESP 84
fn3 pfam00041
Fibronectin type III domain;
1163-1243 5.94e-16

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 74.37  E-value: 5.94e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311592 1163 GAPQNPNAKAAGSRKIHFNWLPP---SGKPMGYRVKYWIQGDSESEAHLLDSKVP-SVELTNLYPYCDYEMKVCAYGAQG 1238
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGEPWNEITVPGTTtSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....*
gi 2217311592 1239 EGPYS 1243
Cdd:pfam00041   81 EGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1556-1640 7.27e-15

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 71.49  E-value: 7.27e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311592  1556 PSAPGPLVFTALSPDSLQLSWERPRRPNGDivGYLVTCEMAQGGGPATAFRVDGDSPESRLTVPGLSENVPYKFKVQART 1635
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGIT--GYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVN 78


                    ....*
gi 2217311592  1636 TEGFG 1640
Cdd:smart00060   79 GAGEG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1255-1348 2.59e-14

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 70.22  E-value: 2.59e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311592 1255 PSEPGRLAFNVVSSTVTQLSWAEPAETNGEITAYEVCYGLVNDDNrpigpMKKVLVDNPKNRMLLIENLRESQPYRYTVK 1334
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGD-----WKEVEVTPGSETSYTLTGLKPGTEYEFRVR 75

                           90
                   ....*....|....
gi 2217311592 1335 ARNGAGWGPEREAI 1348
Cdd:cd00063     76 AVNGGGESPPSESV 89
fn3 pfam00041
Fibronectin type III domain;
1256-1344 3.17e-14

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 69.37  E-value: 3.17e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311592 1256 SEPGRLAFNVVSSTVTQLSWAEPAETNGEITAYEVCYGLVNDdnrpIGPMKKVLVDNPKNRMLLiENLRESQPYRYTVKA 1335
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNS----GEPWNEITVPGTTTSVTL-TGLKPGTEYEVRVQA 75


                   ....*....
gi 2217311592 1336 RNGAGWGPE 1344
Cdd:pfam00041   76 VNGGGEGPP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1163-1250 1.95e-13

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 67.52  E-value: 1.95e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311592 1163 GAPQNPNAKAAGSRKIHFNWLPPS---GKPMGYRVKYWIQGDSE-SEAHLLDSKVPSVELTNLYPYCDYEMKVCAYGAQG 1238
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                           90
                   ....*....|..
gi 2217311592 1239 EGPYSSLVSCRT 1250
Cdd:cd00063     82 ESPPSESVTVTT 93
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1164-1340 1.82e-10

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 65.79  E-value: 1.82e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311592 1164 APQNPNAKAAGSRKIHFNWLPPSGKP-MGYRVKYWIQGDSESEahlldsKVPSVELTNlypYCD--------YEMKVCAY 1234
Cdd:COG3401    235 APTGLTATADTPGSVTLSWDPVTESDaTGYRVYRSNSGDGPFT------KVATVTTTS---YTDtgltngttYYYRVTAV 305

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311592 1235 GAQG-EGPYSSLVSCRTHQEVPSEPGRLAFNVVSSTVTQLSWAEPaeTNGEITAYEVCYglvndDNRPIGPMKKVlVDNP 1313
Cdd:COG3401    306 DAAGnESAPSNVVSVTTDLTPPAAPSGLTATAVGSSSITLSWTAS--SDADVTGYNVYR-----STSGGGTYTKI-AETV 377

                          170       180
                   ....*....|....*....|....*..
gi 2217311592 1314 KNRMLLIENLRESQPYRYTVKARNGAG 1340
Cdd:COG3401    378 TTTSYTDTGLTPGTTYYYKVTAVDAAG 404
I-EGF_1 pfam18372
Integrin beta epidermal growth factor like domain 1; This is the I-EGF 1 domain found in ...
 492-520 2.09e-10

Integrin beta epidermal growth factor like domain 1; This is the I-EGF 1 domain found in several integrin betas such as integrin beta 1-7. Structural analysis reveal an epidermal growth factor-like (I-EGF) domains 1 and 2. EGF1 lacks one disulfide (C2-C4) relative to the integrin EGF 2, 3, and 4 domains, this allows the C-terminal end of EGF1 to flex remarkably relative to its N-terminal end.


Pssm-ID: 465729  Cd Length: 29  Bit Score: 57.11  E-value: 2.09e-10
                           10        20
                   ....*....|....*....|....*....
gi 2217311592  492 CELQKEVRSARCSFNGDFVCGQCVCSEGW 520
Cdd:pfam18372    1 CEKQAEPNSPRCSGNGTFVCGVCVCNPGY 29
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 1027-1141 5.49e-10

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 64.43  E-value: 5.49e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311592 1027 VSFEQPEFSVSRGDQVARIPVIRRVLDGGKS-QVSYRTQDGTAQGNRDYIPVEGELLFQPGEAWKELQVKLL--ELQEVD 1103
Cdd:TIGR00845  402 IFFEPGHYTCLENCGTVALTVVRRGGDLTNTvYVDYRTEDGTANAGSDYEFTEGTLVFKPGETQKEFRIGIIddDIFEED 481

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 2217311592 1104 sllrgrqvRRFHVQLSNPKFG--------------AHLGQPHSTTIIIRDPD 1141
Cdd:TIGR00845  482 --------EHFYVRLSNLRVGsedgileanhvsavAQLASPNTATVTILDDD 525
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1163-1240 1.39e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 56.47  E-value: 1.39e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311592  1163 GAPQNPNAKAAGSRKIHFNWLPP-SGKPMGYRVKYWIQGDSESEA---HLLDSKVPSVELTNLYPYCDYEMKVCAYGAQG 1238
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPpDDGITGYIVGYRVEYREEGSEwkeVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 2217311592  1239 EG 1240
Cdd:smart00060   82 EG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1255-1342 1.75e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 56.08  E-value: 1.75e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311592  1255 PSEPGRLAFNVVSSTVTQLSWAEPAETNGeiTAYEVCYGLVNddnRPIGPMKKVLVDNPKNRMLLIENLRESQPYRYTVK 1334
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGI--TGYIVGYRVEY---REEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75


                    ....*...
gi 2217311592  1335 ARNGAGWG 1342
Cdd:smart00060   76 AVNGAGEG 83
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1494-1638 3.38e-08

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 58.48  E-value: 3.38e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311592 1494 NPAQTSVVVEDLLPNHSYVFRVRAQSQEGWGREREGVitiesqvhpqsplcplpgSAFTLST-PSAPGPLVFTALSPDSL 1572
Cdd:COG3401    188 TSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEV------------------SVTTPTTpPSAPTGLTATADTPGSV 249

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2217311592 1573 QLSWERPrrPNGDIVGYLVtcemAQGGGPATAFRVDGDSPESRLTVPGLSENVPYKFKVQARTTEG 1638
Cdd:COG3401    250 TLSWDPV--TESDATGYRV----YRSNSGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAG 309
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1181-1340 1.98e-06

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 52.70  E-value: 1.98e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311592 1181 NWLPPSGKPMGYRVKYWIQGDSESEAHLLDSKVPSVELTNLYPYCDYEMKVCAYGAQGEGPYSSLVSCRTHQEVPSEPGR 1260
Cdd:COG3401    159 TASSVAGAGVVVSPDTSATAAVATTSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTG 238

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311592 1261 LAFNVVSSTVTQLSWAEPAETNgeITAYEVCYGLVNDdnrpiGPMKKvlVDNPKNRMLLIENLRESQPYRYTVKARNGAG 1340
Cdd:COG3401    239 LTATADTPGSVTLSWDPVTESD--ATGYRVYRSNSGD-----GPFTK--VATVTTTSYTDTGLTNGTTYYYRVTAVDAAG 309
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1483-1524 4.96e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 46.72  E-value: 4.96e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2217311592 1483 SHGELHRLNIPNPAQTSVVVEDLLPNHSYVFRVRAQSQEGWG 1524
Cdd:cd00063     42 GSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGES 83
fn3 pfam00041
Fibronectin type III domain;
1485-1526 6.51e-06

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 45.87  E-value: 6.51e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2217311592 1485 GELHRLNIPNPaQTSVVVEDLLPNHSYVFRVRAQSQEGWGRE 1526
Cdd:pfam00041   44 EPWNEITVPGT-TTSVTLTGLKPGTEYEVRVQAVNGGGEGPP 84
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1494-1524 3.10e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 44.14  E-value: 3.10e-05
                            10        20        30
                    ....*....|....*....|....*....|.
gi 2217311592  1494 NPAQTSVVVEDLLPNHSYVFRVRAQSQEGWG 1524
Cdd:smart00060   53 TPSSTSYTLTGLKPGTEYEFRVRAVNGAGEG 83
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 585-608 1.55e-03

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 37.33  E-value: 1.55e-03
                           10        20
                   ....*....|....*....|....*.
gi 2217311592  585 LCNDRGRCSM--GQCVCEPGWTGPSC 608
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1146-1303 2.63e-03

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 42.68  E-value: 2.63e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311592 1146 SFTSQMLSSQPPPhgdlGAPQNPNAKAAGSRKIHFNWLPPSGKP-MGYRVKYWIQGDSESEAHLLDSKVPSVELTNLYPY 1224
Cdd:COG3401    315 SNVVSVTTDLTPP----AAPSGLTATAVGSSSITLSWTASSDADvTGYNVYRSTSGGGTYTKIAETVTTTSYTDTGLTPG 390

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311592 1225 CDYEMKVCAYGAQG-EGPYSSLVSCRT----HQEVPSEPGRLAFNVVSSTVTQLSWAEPAETNGEITAYEVCYGLVNDDN 1299
Cdd:COG3401    391 TTYYYKVTAVDAAGnESAPSEEVSATTasaaSGESLTASVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPF 470


                   ....
gi 2217311592 1300 RPIG 1303
Cdd:COG3401    471 TTTS 474
 
Name Accession Description Interval E-value
INB smart00187
Integrin beta subunits (N-terminal portion of extracellular region); Portion of beta integrins ...
 72-488 0e+00

Integrin beta subunits (N-terminal portion of extracellular region); Portion of beta integrins that lies N-terminal to their EGF-like repeats. Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Beta integrins are proposed to have a von Willebrand factor type-A "insert" or "I" -like domain (although this remains to be confirmed).


Pssm-ID: 197563 [Multi-domain]  Cd Length: 423  Bit Score: 614.71  E-value: 0e+00
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311592    72 SCTECVRVDKDCAYCTDEMFRDR---RCNTQAELLAAGCQRESIVVMESSFQITEETQID---TTLRRSQMSPQGLRVRL 145
Cdd:smart00187    1 SCEECIQSGPNCAWCTDENFTSGgsaRCDTRANLLAKGCSPESIENPASSAEVLEDKPLSdkgSGGQAVQVSPQRVRLKL 80

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311592   146 RPGEERHFELEVFEPLESPVDLYILMDFSNSMSDDLDNLKKMGQNLARVLSQLTSDYTIGFGKFVDKVSVPQTDMRPEKL 225
Cdd:smart00187   81 RPGEPQNFTLTVRQAEDYPVDLYYLMDLSYSMKDDLDNLKSLGDDLAREMKGLTSNFRLGFGSFVDKTVSPFVSTHPEKL 160

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311592   226 KEPWPN----SDPPFSFKNVISLTEDVDEFRNKLQGERISGNLDAPEGGFDAILQTAVCTRDIGWRPDSTHLLVFSTESA 301
Cdd:smart00187  161 ENPCPNynktCEPPYGFKHVLSLTDDTDEFNEEVGKQRISGNLDAPEGGFDAIMQAAVCTEQIGWREDARRLLVFSTDAG 240

                           250       260       270       280       290       300       310       320
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311592   302 FHYEADGAnvLAGIMSRNDERCHLDTTGTYTQYRTQDYPSVPTLVRLLAKHNIIPIFAVTNYSYSYYEKLHTYFPVSSLG 381
Cdd:smart00187  241 FHFAGDGK--LGGIVTPNDGQCHLDNNGEYTMSTTQDYPSIGQLAQKLAENNINPIFAVTKKQVSLYKELSALIPGSSVG 318

                           330       340       350       360       370       380       390       400
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311592   382 VLQEDSSNIVELLEEAFNRIRSNLDIRALDSPRGLRTEVTSkMFQKTRTGSFHirRGEVGIYQVQLRALEHVDGTHVCQl 461
Cdd:smart00187  319 ELSEDSSNVVELIKDAYNKISSRVELEDNALPEGVSVTYTS-SCPGGVTGPGT--RKCEGVKIGDTVSFEVTVTATKCP- 394

                           410       420
                    ....*....|....*....|....*...
gi 2217311592   462 PEDQKGNIHLKP-SFSDGLKMDAGIICD 488
Cdd:smart00187  395 PEDQEQSIRIRPvGFSETLEVEVTFLCD 422
Integrin_beta pfam00362
Integrin beta chain VWA domain; Integrins have been found in animals and their homologs have ...
 160-405 7.80e-150

Integrin beta chain VWA domain; Integrins have been found in animals and their homologs have also been found in cyanobacteria, probably due to horizontal gene transfer. This domain corresponds to the integrin beta VWA domain.


Pssm-ID: 459781  Cd Length: 248  Bit Score: 459.27  E-value: 7.80e-150
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311592  160 PLESPVDLYILMDFSNSMSDDLDNLKKMGQNLARVLSQLTSDYTIGFGKFVDKVSVPQTDMRPEKLKEPWPNS----DPP 235
Cdd:pfam00362    1 AEDYPVDLYYLMDLSYSMKDDLDNLKKLGNDLAEEMRNITSNFRLGFGSFVDKPVMPYISTRPEKLKNPCPGEneqcDPP 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311592  236 FSFKNVISLTEDVDEFRNKLQGERISGNLDAPEGGFDAILQTAVCTRDIGWRPDSTHLLVFSTESAFHYEADGAnvLAGI 315
Cdd:pfam00362   81 FGFRHVLSLTNDIEEFTEEVQKQRISGNLDAPEGGFDAIMQAAVCKDQIGWRNEARRLLVFSTDAGFHYAGDGK--LAGI 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311592  316 MSRNDERCHLDTTGTYTQYRTQDYPSVPTLVRLLAKHNIIPIFAVTNYSYSYYEKLHTYFPVSSLGVLQEDSSNIVELLE 395
Cdd:pfam00362  159 VTPNDGQCHLDSNGEYTKSTEQDYPSLGQLVRKLSENNINPIFAVTEEQYSLYEKLSKLIPGSSVGVLSEDSSNIVQLIK 238

                          250
                   ....*....|
gi 2217311592  396 EAFNRIRSNL 405
Cdd:pfam00362  239 EAYEKIRSKV 248
Integrin_B_tail pfam07965
Integrin beta tail domain; This is the beta tail domain of the Integrin protein. Integrins are ...
 661-744 5.32e-27

Integrin beta tail domain; This is the beta tail domain of the Integrin protein. Integrins are receptors which are involved in cell-cell and cell-extracellular matrix interactions.


Pssm-ID: 462325  Cd Length: 84  Bit Score: 105.82  E-value: 5.32e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311592  661 CEDLRSCVQCQAWGTGEKKGRTC-EECNFKVKMVDELKRAEE-VVVRCSFRDEdDDCTYSYTMEGDgaPGPNSTVLVHKK 738
Cdd:pfam07965    1 CEEKKSCVECQAFKTGPLKEKNCsRNCKFEIILVEVLKEDEEpGAVLCSFKDE-DDCWFTFTYYED--ESGKYVVHVQKE 77


                   ....*.
gi 2217311592  739 KDCPPG 744
Cdd:pfam07965   78 RECPPG 83
Calx-beta pfam03160
Calx-beta domain;
1025-1119 3.36e-25

Calx-beta domain;


Pssm-ID: 397326 [Multi-domain]  Cd Length: 91  Bit Score: 101.17  E-value: 3.36e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311592 1025 DVVSFEQPEFSVSRGDQVARIPVIRRVLD-GGKSQVSYRTQDGTAQGNRDYIPVEGELLFQPGEAWKELQVKLLElqevD 1103
Cdd:pfam03160    2 GVIGFEPPTYQVSENDGVAEVCVVRMSGTlRRTVVVPYRTEDGTATAGDDYEPVEGELVFGPGETEKCINVTIID----D 77

                           90
                   ....*....|....*.
gi 2217311592 1104 SLLRGRqvRRFHVQLS 1119
Cdd:pfam03160   78 DVYEGD--ENFFVLLS 91
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 1026-1119 2.69e-23

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 95.40  E-value: 2.69e-23
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311592  1026 VVSFEQPEFSVSRGDQVARIPVIRRVLDGGKSQVSYRTQDGTAQGNRDYIPVEGELLFQPGEAWKELQVKLLelqeVDSL 1105
Cdd:smart00237    3 SVGFEQPVYTVSESDGEVEVCVVRTGGARGPVVVPYSTEDGTATAGSDYEPVPGELTFPPGETEKEIRIKII----DDDI 78

                            90
                    ....*....|....
gi 2217311592  1106 LRGrqVRRFHVQLS 1119
Cdd:smart00237   79 YEK--DETFYVRLS 90
fn3 pfam00041
Fibronectin type III domain;
1557-1642 2.39e-21

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 89.78  E-value: 2.39e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311592 1557 SAPGPLVFTALSPDSLQLSWERPRRPNGDIVGYLVTCEMAQGGGPATAFRVDGDspESRLTVPGLSENVPYKFKVQARTT 1636
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGEPWNEITVPGT--TTSVTLTGLKPGTEYEVRVQAVNG 78


                   ....*.
gi 2217311592 1637 EGFGPE 1642
Cdd:pfam00041   79 GGEGPP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1556-1641 2.55e-17

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 78.69  E-value: 2.55e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311592 1556 PSAPGPLVFTALSPDSLQLSWERPRRPNGDIVGYLVTCEMAQGGGPATAFRVDGDspESRLTVPGLSENVPYKFKVQART 1635
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVTPGS--ETSYTLTGLKPGTEYEFRVRAVN 78


                   ....*.
gi 2217311592 1636 TEGFGP 1641
Cdd:cd00063     79 GGGESP 84
fn3 pfam00041
Fibronectin type III domain;
1163-1243 5.94e-16

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 74.37  E-value: 5.94e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311592 1163 GAPQNPNAKAAGSRKIHFNWLPP---SGKPMGYRVKYWIQGDSESEAHLLDSKVP-SVELTNLYPYCDYEMKVCAYGAQG 1238
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGEPWNEITVPGTTtSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....*
gi 2217311592 1239 EGPYS 1243
Cdd:pfam00041   81 EGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1556-1640 7.27e-15

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 71.49  E-value: 7.27e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311592  1556 PSAPGPLVFTALSPDSLQLSWERPRRPNGDivGYLVTCEMAQGGGPATAFRVDGDSPESRLTVPGLSENVPYKFKVQART 1635
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGIT--GYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVN 78


                    ....*
gi 2217311592  1636 TEGFG 1640
Cdd:smart00060   79 GAGEG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1255-1348 2.59e-14

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 70.22  E-value: 2.59e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311592 1255 PSEPGRLAFNVVSSTVTQLSWAEPAETNGEITAYEVCYGLVNDDNrpigpMKKVLVDNPKNRMLLIENLRESQPYRYTVK 1334
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGD-----WKEVEVTPGSETSYTLTGLKPGTEYEFRVR 75

                           90
                   ....*....|....
gi 2217311592 1335 ARNGAGWGPEREAI 1348
Cdd:cd00063     76 AVNGGGESPPSESV 89
fn3 pfam00041
Fibronectin type III domain;
1256-1344 3.17e-14

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 69.37  E-value: 3.17e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311592 1256 SEPGRLAFNVVSSTVTQLSWAEPAETNGEITAYEVCYGLVNDdnrpIGPMKKVLVDNPKNRMLLiENLRESQPYRYTVKA 1335
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNS----GEPWNEITVPGTTTSVTL-TGLKPGTEYEVRVQA 75


                   ....*....
gi 2217311592 1336 RNGAGWGPE 1344
Cdd:pfam00041   76 VNGGGEGPP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1163-1250 1.95e-13

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 67.52  E-value: 1.95e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311592 1163 GAPQNPNAKAAGSRKIHFNWLPPS---GKPMGYRVKYWIQGDSE-SEAHLLDSKVPSVELTNLYPYCDYEMKVCAYGAQG 1238
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                           90
                   ....*....|..
gi 2217311592 1239 EGPYSSLVSCRT 1250
Cdd:cd00063     82 ESPPSESVTVTT 93
PSI_integrin pfam17205
Integrin plexin domain; This short disulphide rich domain is found at the N-terminus of ...
 63-108 9.26e-11

Integrin plexin domain; This short disulphide rich domain is found at the N-terminus of integrin beta chains.


Pssm-ID: 465380  Cd Length: 47  Bit Score: 58.33  E-value: 9.26e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 2217311592   63 NRCKKApVKSCTECVRVDKDCAYCTDEMF--RDRRCNTQAELLAAGCQ 108
Cdd:pfam17205    1 NRCTSA-STSCEECIQSGPDCAWCTDENFtsGSPRCDTRENLLARGCS 47
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1164-1340 1.82e-10

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 65.79  E-value: 1.82e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311592 1164 APQNPNAKAAGSRKIHFNWLPPSGKP-MGYRVKYWIQGDSESEahlldsKVPSVELTNlypYCD--------YEMKVCAY 1234
Cdd:COG3401    235 APTGLTATADTPGSVTLSWDPVTESDaTGYRVYRSNSGDGPFT------KVATVTTTS---YTDtgltngttYYYRVTAV 305

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311592 1235 GAQG-EGPYSSLVSCRTHQEVPSEPGRLAFNVVSSTVTQLSWAEPaeTNGEITAYEVCYglvndDNRPIGPMKKVlVDNP 1313
Cdd:COG3401    306 DAAGnESAPSNVVSVTTDLTPPAAPSGLTATAVGSSSITLSWTAS--SDADVTGYNVYR-----STSGGGTYTKI-AETV 377

                          170       180
                   ....*....|....*....|....*..
gi 2217311592 1314 KNRMLLIENLRESQPYRYTVKARNGAG 1340
Cdd:COG3401    378 TTTSYTDTGLTPGTTYYYKVTAVDAAG 404
I-EGF_1 pfam18372
Integrin beta epidermal growth factor like domain 1; This is the I-EGF 1 domain found in ...
 492-520 2.09e-10

Integrin beta epidermal growth factor like domain 1; This is the I-EGF 1 domain found in several integrin betas such as integrin beta 1-7. Structural analysis reveal an epidermal growth factor-like (I-EGF) domains 1 and 2. EGF1 lacks one disulfide (C2-C4) relative to the integrin EGF 2, 3, and 4 domains, this allows the C-terminal end of EGF1 to flex remarkably relative to its N-terminal end.


Pssm-ID: 465729  Cd Length: 29  Bit Score: 57.11  E-value: 2.09e-10
                           10        20
                   ....*....|....*....|....*....
gi 2217311592  492 CELQKEVRSARCSFNGDFVCGQCVCSEGW 520
Cdd:pfam18372    1 CEKQAEPNSPRCSGNGTFVCGVCVCNPGY 29
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 1027-1141 5.49e-10

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 64.43  E-value: 5.49e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311592 1027 VSFEQPEFSVSRGDQVARIPVIRRVLDGGKS-QVSYRTQDGTAQGNRDYIPVEGELLFQPGEAWKELQVKLL--ELQEVD 1103
Cdd:TIGR00845  402 IFFEPGHYTCLENCGTVALTVVRRGGDLTNTvYVDYRTEDGTANAGSDYEFTEGTLVFKPGETQKEFRIGIIddDIFEED 481

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 2217311592 1104 sllrgrqvRRFHVQLSNPKFG--------------AHLGQPHSTTIIIRDPD 1141
Cdd:TIGR00845  482 --------EHFYVRLSNLRVGsedgileanhvsavAQLASPNTATVTILDDD 525
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1163-1240 1.39e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 56.47  E-value: 1.39e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311592  1163 GAPQNPNAKAAGSRKIHFNWLPP-SGKPMGYRVKYWIQGDSESEA---HLLDSKVPSVELTNLYPYCDYEMKVCAYGAQG 1238
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPpDDGITGYIVGYRVEYREEGSEwkeVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 2217311592  1239 EG 1240
Cdd:smart00060   82 EG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1255-1342 1.75e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 56.08  E-value: 1.75e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311592  1255 PSEPGRLAFNVVSSTVTQLSWAEPAETNGeiTAYEVCYGLVNddnRPIGPMKKVLVDNPKNRMLLIENLRESQPYRYTVK 1334
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGI--TGYIVGYRVEY---REEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75


                    ....*...
gi 2217311592  1335 ARNGAGWG 1342
Cdd:smart00060   76 AVNGAGEG 83
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1494-1638 3.38e-08

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 58.48  E-value: 3.38e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311592 1494 NPAQTSVVVEDLLPNHSYVFRVRAQSQEGWGREREGVitiesqvhpqsplcplpgSAFTLST-PSAPGPLVFTALSPDSL 1572
Cdd:COG3401    188 TSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEV------------------SVTTPTTpPSAPTGLTATADTPGSV 249

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2217311592 1573 QLSWERPrrPNGDIVGYLVtcemAQGGGPATAFRVDGDSPESRLTVPGLSENVPYKFKVQARTTEG 1638
Cdd:COG3401    250 TLSWDPV--TESDATGYRV----YRSNSGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAG 309
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1492-1661 6.65e-07

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 54.24  E-value: 6.65e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311592 1492 IPNPAQTSVVVEDLLPNHSYVFRVRAQSQEGwgreregvitIESqvhPQSPlcplPGSAFT-LSTPSAPGPLVFTALSPD 1570
Cdd:COG3401    279 VATVTTTSYTDTGLTNGTTYYYRVTAVDAAG----------NES---APSN----VVSVTTdLTPPAAPSGLTATAVGSS 341

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311592 1571 SLQLSWERPrrPNGDIVGYLVTcemaQGGGPATAFRVDGDSP-ESRLTVPGLSENVPYKFKVQARTTEGFGPEREGIITI 1649
Cdd:COG3401    342 SITLSWTAS--SDADVTGYNVY----RSTSGGGTYTKIAETVtTTSYTDTGLTPGTTYYYKVTAVDAAGNESAPSEEVSA 415

                          170
                   ....*....|..
gi 2217311592 1650 ESQDGGPFPQLG 1661
Cdd:COG3401    416 TTASAASGESLT 427
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1181-1340 1.98e-06

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 52.70  E-value: 1.98e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311592 1181 NWLPPSGKPMGYRVKYWIQGDSESEAHLLDSKVPSVELTNLYPYCDYEMKVCAYGAQGEGPYSSLVSCRTHQEVPSEPGR 1260
Cdd:COG3401    159 TASSVAGAGVVVSPDTSATAAVATTSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTG 238

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311592 1261 LAFNVVSSTVTQLSWAEPAETNgeITAYEVCYGLVNDdnrpiGPMKKvlVDNPKNRMLLIENLRESQPYRYTVKARNGAG 1340
Cdd:COG3401    239 LTATADTPGSVTLSWDPVTESD--ATGYRVYRSNSGD-----GPFTK--VATVTTTSYTDTGLTNGTTYYYRVTAVDAAG 309
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 1013-1122 2.03e-06

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 52.87  E-value: 2.03e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311592 1013 LVNITIIKEQARDVVSFEQPEFSVSRGDQVARIPVIRRVLDGGKSQVSYRTQDGTAQ-GNRDYIPVEGELLFQPGEAWKE 1091
Cdd:TIGR00845  516 TATVTILDDDHAGIFTFEEDVFHVSESIGIMEVKVLRTSGARGTVIVPYRTVEGTARgGGKDFEDTCGELEFENDETEKT 595

                           90       100       110
                   ....*....|....*....|....*....|.
gi 2217311592 1092 LQVKLLELQEVDsllrgRQVrRFHVQLSNPK 1122
Cdd:TIGR00845  596 IRVKIVDDEEYE-----KND-TFFIELGEPR 620
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1483-1524 4.96e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 46.72  E-value: 4.96e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2217311592 1483 SHGELHRLNIPNPAQTSVVVEDLLPNHSYVFRVRAQSQEGWG 1524
Cdd:cd00063     42 GSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGES 83
fn3 pfam00041
Fibronectin type III domain;
1485-1526 6.51e-06

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 45.87  E-value: 6.51e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2217311592 1485 GELHRLNIPNPaQTSVVVEDLLPNHSYVFRVRAQSQEGWGRE 1526
Cdd:pfam00041   44 EPWNEITVPGT-TTSVTLTGLKPGTEYEVRVQAVNGGGEGPP 84
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1494-1524 3.10e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 44.14  E-value: 3.10e-05
                            10        20        30
                    ....*....|....*....|....*....|.
gi 2217311592  1494 NPAQTSVVVEDLLPNHSYVFRVRAQSQEGWG 1524
Cdd:smart00060   53 TPSSTSYTLTGLKPGTEYEFRVRAVNGAGEG 83
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 585-608 1.55e-03

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 37.33  E-value: 1.55e-03
                           10        20
                   ....*....|....*....|....*.
gi 2217311592  585 LCNDRGRCSM--GQCVCEPGWTGPSC 608
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1146-1303 2.63e-03

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 42.68  E-value: 2.63e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311592 1146 SFTSQMLSSQPPPhgdlGAPQNPNAKAAGSRKIHFNWLPPSGKP-MGYRVKYWIQGDSESEAHLLDSKVPSVELTNLYPY 1224
Cdd:COG3401    315 SNVVSVTTDLTPP----AAPSGLTATAVGSSSITLSWTASSDADvTGYNVYRSTSGGGTYTKIAETVTTTSYTDTGLTPG 390

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217311592 1225 CDYEMKVCAYGAQG-EGPYSSLVSCRT----HQEVPSEPGRLAFNVVSSTVTQLSWAEPAETNGEITAYEVCYGLVNDDN 1299
Cdd:COG3401    391 TTYYYKVTAVDAAGnESAPSEEVSATTasaaSGESLTASVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPF 470


                   ....
gi 2217311592 1300 RPIG 1303
Cdd:COG3401    471 TTTS 474
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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