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Conserved domains on  [gi|2217312697|ref|XP_047292307|]
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vacuolar protein sorting-associated protein 53 homolog isoform X8 [Homo sapiens]

Protein Classification

Vps53-like N-terminal domain-containing protein( domain architecture ID 10513706)

Vps53-like N-terminal domain-containing protein similar to Arabidopsis thaliana vacuolar protein sorting-associated protein 53 B that is involved in retrograde transport from early and late endosomes to late Golgi, leading to the membrane fusion between late Golgi and endosomal vesicles

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Vps53_N pfam04100
Vps53-like, N-terminal; Vps53 complexes with Vps52 and Vps54 to form a multi- subunit complex ...
 40-401 0e+00

Vps53-like, N-terminal; Vps53 complexes with Vps52 and Vps54 to form a multi- subunit complex involved in regulating membrane trafficking events.


:

Pssm-ID: 427710  Cd Length: 372  Bit Score: 515.85  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217312697  40 ADFNAVEYINTLFPTEQSLANIDEVVNKIRLKIRRLDDNIRTVVRGQTNVGQDGRQALEEAQKAIQQLFGKIKDIKDKAE 119
Cdd:pfam04100   1 PDFSAVEYINELFPTEQSLTNIDELIQKLQEEIRKLDNNIKTVVRGQANVGEKGEEALDEAQKAIRSLFQKIKEIKSVAE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217312697 120 KSEQMVKEITRDIKQLDHAKRHLTTSITTLNHLHMLAGGVDSLEAMTRRRQYGEVANLLQGVMNVLEHFHKYMGIPQIRQ 199
Cdd:pfam04100  81 STEEMVKEITRDIKQLDIAKRNLTTSITTLHHLHMLVTGVESLNALLSKRSYGEAASPLQAILQLLNHFIKYKSVDEIAN 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217312697 200 LSERVKAAQTELGQQILADFEEAF--PSQGTKRPGGPSNVLRDACLVANILDPRIKQEIIKKFIKQHLSEYLVLFQENQD 277
Cdd:pfam04100 161 LSESISKLKGSLLSQIFQDFKSAFsgGSQGEHRTGLLLQLLEDACRVADILDPSVKEELIKWFIDQQLEEYKEIFRENEE 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217312697 278 VAWLDKIDRRYAWIKRQLVDYEEKYGRMFPREWCMAERIAVEFCHVTRAELAKIMRTRAKEIEVKLLLFAIQRTTNFEGF 357
Cdd:pfam04100 241 AAWLDKLDRRYAWFKRILNDFEEKYGPIFPADWEMAERLTVEFCHQTRKDLAKILKRRDKEPSVKLLLFALQSTLEFEKF 320

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 2217312697 358 LAKRFsgctltdgtlkklespppstnpfleDEPTPEMEELATEK 401
Cdd:pfam04100 321 LDKRF-------------------------SKKTPEPKELAFHG 339
 
Name Accession Description Interval E-value
Vps53_N pfam04100
Vps53-like, N-terminal; Vps53 complexes with Vps52 and Vps54 to form a multi- subunit complex ...
 40-401 0e+00

Vps53-like, N-terminal; Vps53 complexes with Vps52 and Vps54 to form a multi- subunit complex involved in regulating membrane trafficking events.


Pssm-ID: 427710  Cd Length: 372  Bit Score: 515.85  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217312697  40 ADFNAVEYINTLFPTEQSLANIDEVVNKIRLKIRRLDDNIRTVVRGQTNVGQDGRQALEEAQKAIQQLFGKIKDIKDKAE 119
Cdd:pfam04100   1 PDFSAVEYINELFPTEQSLTNIDELIQKLQEEIRKLDNNIKTVVRGQANVGEKGEEALDEAQKAIRSLFQKIKEIKSVAE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217312697 120 KSEQMVKEITRDIKQLDHAKRHLTTSITTLNHLHMLAGGVDSLEAMTRRRQYGEVANLLQGVMNVLEHFHKYMGIPQIRQ 199
Cdd:pfam04100  81 STEEMVKEITRDIKQLDIAKRNLTTSITTLHHLHMLVTGVESLNALLSKRSYGEAASPLQAILQLLNHFIKYKSVDEIAN 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217312697 200 LSERVKAAQTELGQQILADFEEAF--PSQGTKRPGGPSNVLRDACLVANILDPRIKQEIIKKFIKQHLSEYLVLFQENQD 277
Cdd:pfam04100 161 LSESISKLKGSLLSQIFQDFKSAFsgGSQGEHRTGLLLQLLEDACRVADILDPSVKEELIKWFIDQQLEEYKEIFRENEE 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217312697 278 VAWLDKIDRRYAWIKRQLVDYEEKYGRMFPREWCMAERIAVEFCHVTRAELAKIMRTRAKEIEVKLLLFAIQRTTNFEGF 357
Cdd:pfam04100 241 AAWLDKLDRRYAWFKRILNDFEEKYGPIFPADWEMAERLTVEFCHQTRKDLAKILKRRDKEPSVKLLLFALQSTLEFEKF 320

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 2217312697 358 LAKRFsgctltdgtlkklespppstnpfleDEPTPEMEELATEK 401
Cdd:pfam04100 321 LDKRF-------------------------SKKTPEPKELAFHG 339
 
Name Accession Description Interval E-value
Vps53_N pfam04100
Vps53-like, N-terminal; Vps53 complexes with Vps52 and Vps54 to form a multi- subunit complex ...
 40-401 0e+00

Vps53-like, N-terminal; Vps53 complexes with Vps52 and Vps54 to form a multi- subunit complex involved in regulating membrane trafficking events.


Pssm-ID: 427710  Cd Length: 372  Bit Score: 515.85  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217312697  40 ADFNAVEYINTLFPTEQSLANIDEVVNKIRLKIRRLDDNIRTVVRGQTNVGQDGRQALEEAQKAIQQLFGKIKDIKDKAE 119
Cdd:pfam04100   1 PDFSAVEYINELFPTEQSLTNIDELIQKLQEEIRKLDNNIKTVVRGQANVGEKGEEALDEAQKAIRSLFQKIKEIKSVAE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217312697 120 KSEQMVKEITRDIKQLDHAKRHLTTSITTLNHLHMLAGGVDSLEAMTRRRQYGEVANLLQGVMNVLEHFHKYMGIPQIRQ 199
Cdd:pfam04100  81 STEEMVKEITRDIKQLDIAKRNLTTSITTLHHLHMLVTGVESLNALLSKRSYGEAASPLQAILQLLNHFIKYKSVDEIAN 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217312697 200 LSERVKAAQTELGQQILADFEEAF--PSQGTKRPGGPSNVLRDACLVANILDPRIKQEIIKKFIKQHLSEYLVLFQENQD 277
Cdd:pfam04100 161 LSESISKLKGSLLSQIFQDFKSAFsgGSQGEHRTGLLLQLLEDACRVADILDPSVKEELIKWFIDQQLEEYKEIFRENEE 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217312697 278 VAWLDKIDRRYAWIKRQLVDYEEKYGRMFPREWCMAERIAVEFCHVTRAELAKIMRTRAKEIEVKLLLFAIQRTTNFEGF 357
Cdd:pfam04100 241 AAWLDKLDRRYAWFKRILNDFEEKYGPIFPADWEMAERLTVEFCHQTRKDLAKILKRRDKEPSVKLLLFALQSTLEFEKF 320

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 2217312697 358 LAKRFsgctltdgtlkklespppstnpfleDEPTPEMEELATEK 401
Cdd:pfam04100 321 LDKRF-------------------------SKKTPEPKELAFHG 339
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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