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Conserved domains on  [gi|2217316540|ref|XP_047293384|]
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structural maintenance of chromosomes flexible hinge domain-containing protein 1 isoform X5 [Homo sapiens]

Protein Classification

ATP-binding protein; sensor histidine kinase( domain architecture ID 13015022)

ATP-binding protein containing histidine kinase-like ATPase domain, similar to Streptomyces subrutilus DNA gyrase an an essential bacterial enzyme that catalyzes the ATP-dependent negative super-coiling of double-stranded closed-circular DNA| sensor histidine kinase, part of a two-component regulatory system, functions as a protein kinase that phosphorylates a target protein in response to various signals; similar to histidine kinase NtrY involved in nitrogen fixation and metabolism regulation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HATPase_SMCHD1-like cd16937
Histidine kinase-like ATPase domain of structural maintenance of chromosomes flexible hinge ...
 128-246 5.11e-84

Histidine kinase-like ATPase domain of structural maintenance of chromosomes flexible hinge domain containing 1 (SMCHD1) protein; This family includes histidine kinase-like ATPase (HATPase) domain of structural maintenance of chromosomes flexible hinge domain containing 1 (SMCHD1) protein, which is involved in gene silencing and in DNA damage. It has critical roles in X-chromosome inactivation and is also an important regulator of autosomal gene clusters. Upon DNA damage, SMCHD1 promotes non-homologous end joining and inhibits homologous recombination repair. SMCHD1 is implicated in the pathogenesis of facioscapulohumeral muscular dystrophy.


:

Pssm-ID: 340414 [Multi-domain]  Cd Length: 119  Bit Score: 269.94  E-value: 5.11e-84
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217316540  128 GMYEYYASEGQNPLPFALAELIDNSLSATSRNIGVRRIQIKLLFDETQGKPAVAVIDNGRGMTSKQLNNWAVYRLSKFTR 207
Cdd:cd16937      1 GMYEYYASEGQNPLPFALAELIDNSLSATRRNTDIRRIQIKLLFDEAQGKPAVAVIDNGRGMTSKQLNNWAVYRLSKFTR 80

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 2217316540  208 QGDFESDHSGYVRPVPVPRSLNSDISYFGVGGKQAVFFV 246
Cdd:cd16937     81 QGDFESDHSGYVRPDPVPRSLNSDISYFGVGGKQAVFFV 119
 
Name Accession Description Interval E-value
HATPase_SMCHD1-like cd16937
Histidine kinase-like ATPase domain of structural maintenance of chromosomes flexible hinge ...
 128-246 5.11e-84

Histidine kinase-like ATPase domain of structural maintenance of chromosomes flexible hinge domain containing 1 (SMCHD1) protein; This family includes histidine kinase-like ATPase (HATPase) domain of structural maintenance of chromosomes flexible hinge domain containing 1 (SMCHD1) protein, which is involved in gene silencing and in DNA damage. It has critical roles in X-chromosome inactivation and is also an important regulator of autosomal gene clusters. Upon DNA damage, SMCHD1 promotes non-homologous end joining and inhibits homologous recombination repair. SMCHD1 is implicated in the pathogenesis of facioscapulohumeral muscular dystrophy.


Pssm-ID: 340414 [Multi-domain]  Cd Length: 119  Bit Score: 269.94  E-value: 5.11e-84
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217316540  128 GMYEYYASEGQNPLPFALAELIDNSLSATSRNIGVRRIQIKLLFDETQGKPAVAVIDNGRGMTSKQLNNWAVYRLSKFTR 207
Cdd:cd16937      1 GMYEYYASEGQNPLPFALAELIDNSLSATRRNTDIRRIQIKLLFDEAQGKPAVAVIDNGRGMTSKQLNNWAVYRLSKFTR 80

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 2217316540  208 QGDFESDHSGYVRPVPVPRSLNSDISYFGVGGKQAVFFV 246
Cdd:cd16937     81 QGDFESDHSGYVRPDPVPRSLNSDISYFGVGGKQAVFFV 119
HATPase_c_3 pfam13589
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents, additionally, ...
 143-255 1.02e-07

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents, additionally, the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 433332 [Multi-domain]  Cd Length: 135  Bit Score: 52.33  E-value: 1.02e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217316540  143 FALAELIDNSLSATSRNigvrrIQIKLLFDETQGKPaVAVIDNGRGMTSKQLNNWavYRLSKFTRQGDFESDhsgyvrpv 222
Cdd:pfam13589    3 GALAELIDNSIDADATN-----IKIEVNKNRGGGTE-IVIEDDGHGMSPEELINA--LRLATSAKEAKRGST-------- 66

                           90       100       110
                   ....*....|....*....|....*....|...
gi 2217316540  223 pvprslnsDISYFGVGGKQAVFFVGQSARMISK 255
Cdd:pfam13589   67 --------DLGRYGIGLKLASLSLGAKLTVTSK 91
 
Name Accession Description Interval E-value
HATPase_SMCHD1-like cd16937
Histidine kinase-like ATPase domain of structural maintenance of chromosomes flexible hinge ...
 128-246 5.11e-84

Histidine kinase-like ATPase domain of structural maintenance of chromosomes flexible hinge domain containing 1 (SMCHD1) protein; This family includes histidine kinase-like ATPase (HATPase) domain of structural maintenance of chromosomes flexible hinge domain containing 1 (SMCHD1) protein, which is involved in gene silencing and in DNA damage. It has critical roles in X-chromosome inactivation and is also an important regulator of autosomal gene clusters. Upon DNA damage, SMCHD1 promotes non-homologous end joining and inhibits homologous recombination repair. SMCHD1 is implicated in the pathogenesis of facioscapulohumeral muscular dystrophy.


Pssm-ID: 340414 [Multi-domain]  Cd Length: 119  Bit Score: 269.94  E-value: 5.11e-84
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217316540  128 GMYEYYASEGQNPLPFALAELIDNSLSATSRNIGVRRIQIKLLFDETQGKPAVAVIDNGRGMTSKQLNNWAVYRLSKFTR 207
Cdd:cd16937      1 GMYEYYASEGQNPLPFALAELIDNSLSATRRNTDIRRIQIKLLFDEAQGKPAVAVIDNGRGMTSKQLNNWAVYRLSKFTR 80

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 2217316540  208 QGDFESDHSGYVRPVPVPRSLNSDISYFGVGGKQAVFFV 246
Cdd:cd16937     81 QGDFESDHSGYVRPDPVPRSLNSDISYFGVGGKQAVFFV 119
HATPase_c_3 pfam13589
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents, additionally, ...
 143-255 1.02e-07

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents, additionally, the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 433332 [Multi-domain]  Cd Length: 135  Bit Score: 52.33  E-value: 1.02e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217316540  143 FALAELIDNSLSATSRNigvrrIQIKLLFDETQGKPaVAVIDNGRGMTSKQLNNWavYRLSKFTRQGDFESDhsgyvrpv 222
Cdd:pfam13589    3 GALAELIDNSIDADATN-----IKIEVNKNRGGGTE-IVIEDDGHGMSPEELINA--LRLATSAKEAKRGST-------- 66

                           90       100       110
                   ....*....|....*....|....*....|...
gi 2217316540  223 pvprslnsDISYFGVGGKQAVFFVGQSARMISK 255
Cdd:pfam13589   67 --------DLGRYGIGLKLASLSLGAKLTVTSK 91
HATPase_MORC-like cd16931
Histidine kinase-like ATPase domain of human microrchidia (MORC) family CW-type zinc finger ...
 142-194 2.66e-03

Histidine kinase-like ATPase domain of human microrchidia (MORC) family CW-type zinc finger proteins MORC1-4, and related domains; This family includes the histidine kinase-like ATPase (HATPase) domain of human microrchidia (MORC) family CW-type zinc finger proteins MORC1-4, and related domains. In addition to the HATPase domain, MORC family proteins have a CW-type zinc finger domain containing four conserved cysteines and two conserved tryptophans, and coiled-coil domains at the carboxy-terminus. MORC1 has cross-species differential methylation in association with early life stress, and genome-wide association with major depressive disorder (MDD). MORC2 is involved in several nuclear processes, including transcription modulation and DNA damage repair, and exhibits a cytosolic function in lipogenesis, adipogenic differentiation, and lipid homeostasis by increasing the activity of ACLY. MORC3 regulates p53, and is an antiviral factor which plays an important role during HSV-1 and HCMV infection, and is a positive regulator of influenza virus transcription. MORC4 is highly expressed in a subset of diffuse large B-cell lymphomas and has potential as a lymphoma biomarker.


Pssm-ID: 340408 [Multi-domain]  Cd Length: 118  Bit Score: 39.31  E-value: 2.66e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2217316540  142 PF-ALAELIDNslsatSRNIGVRRIQIKLLFDET-QGKPAVAVIDNGRGMTSKQL 194
Cdd:cd16931     12 PFgAVAELVDN-----ARDADATRLDIFIDDINLlRGGFMLSFLDDGNGMTPEEA 61
HATPase_MutL-MLH-PMS-like cd16926
Histidine kinase-like ATPase domain of DNA mismatch repair proteins Escherichia coli MutL, ...
 147-216 5.07e-03

Histidine kinase-like ATPase domain of DNA mismatch repair proteins Escherichia coli MutL, human MutL homologs (MLH/ PMS), and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of Escherichia coli MutL, human MLH1 (mutL homolog 1), human PMS1 (PMS1 homolog 1, mismatch repair system component), human MLH3 (mutL homolog 3), and human PMS2 (PMS1 homolog 2, mismatch repair system component). MutL homologs (MLH/PMS) participate in MMR (DNA mismatch repair), and in addition have role(s) in DNA damage signaling and suppression of homologous recombination (recombination between partially homologous parental DNAs). The primary role of MutL in MMR is to mediate protein-protein interactions during mismatch recognition and strand removal; a ternary complex is formed between MutS, MutL, and the mismatched DNA, which activates the MutH endonuclease.


Pssm-ID: 340403 [Multi-domain]  Cd Length: 188  Bit Score: 39.73  E-value: 5.07e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2217316540  147 ELIDNSLSAtsrniGVRRIQIKLlfdETQGKPAVAVIDNGRGMTSKQLNNwAVYR--LSKFTRQGDFESDHS 216
Cdd:cd16926     20 ELVENSIDA-----GATRIDVEI---EEGGLKLIRVTDNGSGISREDLEL-AFERhaTSKISSFEDLFSITT 82
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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