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Conserved domains on  [gi|2217321009|ref|XP_047294714|]
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ADAMTS-like protein 5 isoform X5 [Homo sapiens]

Protein Classification

ADAMTS_spacer1 and NTR_like domain-containing protein( domain architecture ID 10380494)

ADAMTS_spacer1 and NTR_like domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NTR_like cd03523
NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in ...
 134-235 7.40e-34

NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the domain plays a role in controlling axon branching in neural development, while the common function of these modules in TIMPs appears to be binding to metzincins. A subset of this family is also known as the C345C domain because it occurs as a C-terminal domain in complement C3, C4 and C5. In C5, the domain interacts with various partners during the formation of the membrane attack complex.


:

Pssm-ID: 239600  Cd Length: 105  Bit Score: 117.57  E-value: 7.40e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217321009 134 HYCGSDFVFQARVLGHHHQAQETRYEVRIQLVYKNRSPL----RAREYVWAPGHCPC-PMLAPHRDYLMAVQRLVSpdgt 208
Cdd:cd03523     2 AFCKSDYVVRAKIKEIKEENDDVKYEVKIIKIYKTGKAKadkaDLRFYYTAPACCPChPILNPGREYLIMGKEEDS---- 77

                          90       100
                  ....*....|....*....|....*...
gi 2217321009 209 QDQLLLPHAGYARPWSPA-EDSRIRLTA 235
Cdd:cd03523    78 QGGLVLDPLSFVEPWSPLsLRQDRRLRE 105
ADAMTS_spacer1 super family cl20316
ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like ...
 4-70 3.36e-16

ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like proteins. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase) and is a subfamily of the metalloprotease family, sharing a high degree of sequence similarity and conserved domain organization among its members. Members of the ADAM-TS family have been implicated in a range of diseases. ADAM-TS-like proteins lack a metalloprotease domain. They resides in the ECM and have regulatory roles. Examples of ADAM-TS-like proteins are papilin and punctin.


The actual alignment was detected with superfamily member pfam05986:

Pssm-ID: 461796  Cd Length: 115  Bit Score: 71.84  E-value: 3.36e-16
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2217321009   4 DGRYVLNGHWVVSP-PGTYEAAGTHVVYTRDTGPQETLQAAGPTSHDLLLQVLLQ---EPNPGIEFEFWLP 70
Cdd:pfam05986  45 QGKYILNGKGSISLnPTYPSLLGTVLEYRRSLPALEELHAPGPTQEDLEIQVLRQygkGTNPGITYEYFIP 115
 
Name Accession Description Interval E-value
NTR_like cd03523
NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in ...
 134-235 7.40e-34

NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the domain plays a role in controlling axon branching in neural development, while the common function of these modules in TIMPs appears to be binding to metzincins. A subset of this family is also known as the C345C domain because it occurs as a C-terminal domain in complement C3, C4 and C5. In C5, the domain interacts with various partners during the formation of the membrane attack complex.


Pssm-ID: 239600  Cd Length: 105  Bit Score: 117.57  E-value: 7.40e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217321009 134 HYCGSDFVFQARVLGHHHQAQETRYEVRIQLVYKNRSPL----RAREYVWAPGHCPC-PMLAPHRDYLMAVQRLVSpdgt 208
Cdd:cd03523     2 AFCKSDYVVRAKIKEIKEENDDVKYEVKIIKIYKTGKAKadkaDLRFYYTAPACCPChPILNPGREYLIMGKEEDS---- 77

                          90       100
                  ....*....|....*....|....*...
gi 2217321009 209 QDQLLLPHAGYARPWSPA-EDSRIRLTA 235
Cdd:cd03523    78 QGGLVLDPLSFVEPWSPLsLRQDRRLRE 105
NTR pfam01759
UNC-6/NTR/C345C module; Sequence similarity between netrin UNC-6 and C345C complement protein ...
 134-232 1.09e-20

UNC-6/NTR/C345C module; Sequence similarity between netrin UNC-6 and C345C complement protein family members, and hence the existence of the UNC-6 module, was first reported in. Subsequently, many additional members of the family were identified on the basis of sequence similarity between the C-terminal domains of netrins, complement proteins C3, C4, C5, secreted frizzled-related proteins, and type I pro-collagen C-proteinase enhancer proteins (PCOLCEs), which are homologous with the N-terminal domains of tissue inhibitors of metalloproteinases (TIMPs). The TIMPs are classified as a separate family in Pfam (pfam00965). This expanded domain family has been named as the NTR module.


Pssm-ID: 396359  Cd Length: 106  Bit Score: 83.55  E-value: 1.09e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217321009 134 HYC-GSDFVFQARVLGHHHQAQETRYEVRIQLVYK--NRSPLRAREYVWAP-GHCPCPMLAPHRDYLMAVQrlVSPDGTQ 209
Cdd:pfam01759   2 KACkGSDYVYKVKVLSVEEEGSFDKYTVKVKEVLKegTDKIQRGKVRLFLKrGDCRCPQLRLGKEYLIMGK--VGDLEGR 79

                          90       100
                  ....*....|....*....|...
gi 2217321009 210 DQLLLPHAGYARPWSPAEDSRIR 232
Cdd:pfam01759  80 GRYVLDKNSWVEPWPTKWECKLR 102
ADAMTS_spacer1 pfam05986
ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like ...
 4-70 3.36e-16

ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like proteins. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase) and is a subfamily of the metalloprotease family, sharing a high degree of sequence similarity and conserved domain organization among its members. Members of the ADAM-TS family have been implicated in a range of diseases. ADAM-TS-like proteins lack a metalloprotease domain. They resides in the ECM and have regulatory roles. Examples of ADAM-TS-like proteins are papilin and punctin.


Pssm-ID: 461796  Cd Length: 115  Bit Score: 71.84  E-value: 3.36e-16
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2217321009   4 DGRYVLNGHWVVSP-PGTYEAAGTHVVYTRDTGPQETLQAAGPTSHDLLLQVLLQ---EPNPGIEFEFWLP 70
Cdd:pfam05986  45 QGKYILNGKGSISLnPTYPSLLGTVLEYRRSLPALEELHAPGPTQEDLEIQVLRQygkGTNPGITYEYFIP 115
C345C smart00643
Netrin C-terminal Domain;
134-214 1.64e-05

Netrin C-terminal Domain;


Pssm-ID: 214759  Cd Length: 114  Bit Score: 42.74  E-value: 1.64e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217321009  134 HYCGS--DFVFQARVLGHHHQAQETRYEVRIQLVYKNRSPL--RAREYVW---APGHCPCPM-LAPHRDYL-MAVQRLVS 204
Cdd:smart00643   3 KACKSdvDYVYKVKVLSVEEEGGFDKYTVKILEVIKSGTDElvRGKNKLRvfiSRASCRCPLlLKLGKSYLiMGKSGDLW 82

                           90
                   ....*....|
gi 2217321009  205 PDGTQDQLLL 214
Cdd:smart00643  83 DAKGRGQYVL 92
 
Name Accession Description Interval E-value
NTR_like cd03523
NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in ...
 134-235 7.40e-34

NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the domain plays a role in controlling axon branching in neural development, while the common function of these modules in TIMPs appears to be binding to metzincins. A subset of this family is also known as the C345C domain because it occurs as a C-terminal domain in complement C3, C4 and C5. In C5, the domain interacts with various partners during the formation of the membrane attack complex.


Pssm-ID: 239600  Cd Length: 105  Bit Score: 117.57  E-value: 7.40e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217321009 134 HYCGSDFVFQARVLGHHHQAQETRYEVRIQLVYKNRSPL----RAREYVWAPGHCPC-PMLAPHRDYLMAVQRLVSpdgt 208
Cdd:cd03523     2 AFCKSDYVVRAKIKEIKEENDDVKYEVKIIKIYKTGKAKadkaDLRFYYTAPACCPChPILNPGREYLIMGKEEDS---- 77

                          90       100
                  ....*....|....*....|....*...
gi 2217321009 209 QDQLLLPHAGYARPWSPA-EDSRIRLTA 235
Cdd:cd03523    78 QGGLVLDPLSFVEPWSPLsLRQDRRLRE 105
NTR pfam01759
UNC-6/NTR/C345C module; Sequence similarity between netrin UNC-6 and C345C complement protein ...
 134-232 1.09e-20

UNC-6/NTR/C345C module; Sequence similarity between netrin UNC-6 and C345C complement protein family members, and hence the existence of the UNC-6 module, was first reported in. Subsequently, many additional members of the family were identified on the basis of sequence similarity between the C-terminal domains of netrins, complement proteins C3, C4, C5, secreted frizzled-related proteins, and type I pro-collagen C-proteinase enhancer proteins (PCOLCEs), which are homologous with the N-terminal domains of tissue inhibitors of metalloproteinases (TIMPs). The TIMPs are classified as a separate family in Pfam (pfam00965). This expanded domain family has been named as the NTR module.


Pssm-ID: 396359  Cd Length: 106  Bit Score: 83.55  E-value: 1.09e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217321009 134 HYC-GSDFVFQARVLGHHHQAQETRYEVRIQLVYK--NRSPLRAREYVWAP-GHCPCPMLAPHRDYLMAVQrlVSPDGTQ 209
Cdd:pfam01759   2 KACkGSDYVYKVKVLSVEEEGSFDKYTVKVKEVLKegTDKIQRGKVRLFLKrGDCRCPQLRLGKEYLIMGK--VGDLEGR 79

                          90       100
                  ....*....|....*....|...
gi 2217321009 210 DQLLLPHAGYARPWSPAEDSRIR 232
Cdd:pfam01759  80 GRYVLDKNSWVEPWPTKWECKLR 102
ADAMTS_spacer1 pfam05986
ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like ...
 4-70 3.36e-16

ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like proteins. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase) and is a subfamily of the metalloprotease family, sharing a high degree of sequence similarity and conserved domain organization among its members. Members of the ADAM-TS family have been implicated in a range of diseases. ADAM-TS-like proteins lack a metalloprotease domain. They resides in the ECM and have regulatory roles. Examples of ADAM-TS-like proteins are papilin and punctin.


Pssm-ID: 461796  Cd Length: 115  Bit Score: 71.84  E-value: 3.36e-16
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2217321009   4 DGRYVLNGHWVVSP-PGTYEAAGTHVVYTRDTGPQETLQAAGPTSHDLLLQVLLQ---EPNPGIEFEFWLP 70
Cdd:pfam05986  45 QGKYILNGKGSISLnPTYPSLLGTVLEYRRSLPALEELHAPGPTQEDLEIQVLRQygkGTNPGITYEYFIP 115
NTR_netrin-1_like cd03579
NTR domain, Netrin-1-like subfamily; The C-terminal NTR domain of netrins is also called ...
 132-237 6.67e-10

NTR domain, Netrin-1-like subfamily; The C-terminal NTR domain of netrins is also called domain C in the context of C. elegans netrin UNC-6. Netrins are secreted proteins that function as tropic cues in the direction of axon growth and cell migration during neural development. These proteins may be chemoattractive to some neurons and chemorepellant for others. In the case of netrin-1, attraction and repulsion responses are mediated by the DCC and UNC-5 receptor families. The biological activities of C. elegans UNC-6, which may either attract or repel migrating cells or axons, are mediated by its different domains. The C-terminal NTR domain of UNC-6 has been shown to inhibit axon branching activity.


Pssm-ID: 239634  Cd Length: 115  Bit Score: 54.94  E-value: 6.67e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217321009 132 LLHYCGSDFVFQARVLGHHHQAQETRYEVRIQLVYK-NRSPLRARE-YVWAPGH---CPCPMLAPHRDYLMAVQrlVSPD 206
Cdd:cd03579     1 LKKYCKKDYAVQAQVLSRETAGEWAKFTVNVQTVYKrGTSRLRRGDqPLWVPRKdlaCKCPKLKVGKSYLLLGK--DEDS 78

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2217321009 207 GTQDQLLLPHAGYARPWSPAEDSRIRLTARR 237
Cdd:cd03579    79 PERGGLILDKRSLVIEWRDEWARRLRRFQRR 109
C345C smart00643
Netrin C-terminal Domain;
134-214 1.64e-05

Netrin C-terminal Domain;


Pssm-ID: 214759  Cd Length: 114  Bit Score: 42.74  E-value: 1.64e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217321009  134 HYCGS--DFVFQARVLGHHHQAQETRYEVRIQLVYKNRSPL--RAREYVW---APGHCPCPM-LAPHRDYL-MAVQRLVS 204
Cdd:smart00643   3 KACKSdvDYVYKVKVLSVEEEGGFDKYTVKILEVIKSGTDElvRGKNKLRvfiSRASCRCPLlLKLGKSYLiMGKSGDLW 82

                           90
                   ....*....|
gi 2217321009  205 PDGTQDQLLL 214
Cdd:smart00643  83 DAKGRGQYVL 92
NTR_TIMP_like cd03577
NTR domain, TIMP-like subfamily; TIMPs, or tissue inibitors of metalloproteases, are essential ...
 134-167 1.51e-03

NTR domain, TIMP-like subfamily; TIMPs, or tissue inibitors of metalloproteases, are essential regulators of extracellular matrix turnover and remodeling. They form complexes with matrix metalloproteases (MMPs) and inactivate them irreversibly by non-covalently binding their active zinc-binding sites. This group contains domains similar to the TIMP NTR domain, which binds MMPs. Members of this group may or may not function as MMP inhibitors.


Pssm-ID: 239632  Cd Length: 116  Bit Score: 37.34  E-value: 1.51e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 2217321009 134 HYCGSDFVFQARVLGHHHQAQ--ETRYEVRIQLVYK 167
Cdd:cd03577    11 KYCQADFVIKVKVLKKKLDGAglNIRYTIEIKKVYK 46
NTR_Sfrp3_like cd03581
NTR domain, Secreted frizzled-related protein (Sfrp) 3-like subfamily; composed of proteins ...
 140-223 4.18e-03

NTR domain, Secreted frizzled-related protein (Sfrp) 3-like subfamily; composed of proteins similar to human Sfrp3 and Sfrp4. Sfrps are soluble proteins containing an NTR domain C-terminal to a cysteine-rich Frizzled domain. They show diverse functions and are thought to work in Wnt signaling indirectly, as modulators or antagonists by binding Wnt ligands, and directly, via the Wnt receptor, Frizzled. They participate in regulating the patterning along the anteroposterior axis in vertebrates. Human Sfrp3 may suppress the growth and invasiveness of androgen-independent prostate cancer cells.


Pssm-ID: 239636  Cd Length: 111  Bit Score: 35.91  E-value: 4.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217321009 140 FVFQARVLGHHHQAQETRYEVRIQLVYKNRSPLRAREYV--WAPGHCPCPMLAPHRDYL-MAVQrlvspDGTQDQLLLPH 216
Cdd:cd03581    10 YVIRAKVKEVKRGCHEVTAVVEVKEILKSSLVNIPRDTVtlYTNSGCLCPPLTPNEEYIiMGYE-----DEERSRLLLVE 84


                  ....*..
gi 2217321009 217 AGYARPW 223
Cdd:cd03581    85 GSLAEKW 91
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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