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Conserved domains on  [gi|2217321603|ref|XP_047294892|]
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urokinase plasminogen activator surface receptor isoform X13 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TFP_LU_ECD_uPAR_rpt2 cd23557
second extracellular domain (ECD) found in urokinase plasminogen activator surface receptor ...
 63-151 4.17e-34

second extracellular domain (ECD) found in urokinase plasminogen activator surface receptor (uPAR) and similar proteins; uPAR (also called U-PAR, or monocyte activation antigen Mo3, or CD87) acts as a receptor for urokinase plasminogen activator. It plays a role in localizing and promoting plasmin formation. It mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form. uPAR contains three extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the second ECD.


:

Pssm-ID: 467087  Cd Length: 85  Bit Score: 117.42  E-value: 4.17e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217321603  63 RSRYLECISCGSSDMSCERGRHQSLQCRSPEEQCLDVVTHWIQegeeGRPKDDRHLRGCGYLPGCPGSNGFHNNDTFHFL 142
Cdd:cd23557     1 RSRYLECYSCGSSDMSCERGRLTSLQCRGPQDQCVDVTTHGSL----ERPKSERRLKGCGTLPGCPGSLGFHNNDTFHLL 76


                  ....*....
gi 2217321603 143 KCCNTTKCN 151
Cdd:cd23557    77 KCCNSSLCN 85
TFP super family cl45932
three-fingered protein (TFP) fold found in Ly6/uPAR (LU) and snake toxin superfamily; The LU ...
 159-209 4.70e-13

three-fingered protein (TFP) fold found in Ly6/uPAR (LU) and snake toxin superfamily; The LU (also known as Ly-6 antigen/uPA receptor)-like extracellular domain (ECD) occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. It is a structural domain involved in protein-protein interactions, tolerating an unusual degree of variation and binding with high specificity to a broad spectrum of targets. The snake toxin domain is present in short and long neurotoxins, cytotoxins, and short toxins, and in other miscellaneous venom peptides. The toxin acts by binding to the nicotinic acetylcholine receptors in the postsynaptic membrane of skeletal muscles and preventing the binding of acetylcholine, thereby blocking the excitation of muscles. Both the LU-like ECD and the snake toxin domain belong to three-fingered protein (TFP) fold, which is characterized by containing 70 to 100 amino acids including eight to ten cysteine residues spaced at conserved distances.


The actual alignment was detected with superfamily member cd23558:

Pssm-ID: 480272  Cd Length: 93  Bit Score: 62.80  E-value: 4.70e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2217321603 159 ENLPQNGRQCYSCKGNSTHGCSSEETFLIDCRGPMNQCLVATGTHERSLWG 209
Cdd:cd23558     1 PDLPPNGIQCYSCNGNSTHGCSSEETSKVRCRGPQTQCLEATGTTAHGGKN 51
TFP super family cl45932
three-fingered protein (TFP) fold found in Ly6/uPAR (LU) and snake toxin superfamily; The LU ...
 23-55 7.38e-07

three-fingered protein (TFP) fold found in Ly6/uPAR (LU) and snake toxin superfamily; The LU (also known as Ly-6 antigen/uPA receptor)-like extracellular domain (ECD) occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. It is a structural domain involved in protein-protein interactions, tolerating an unusual degree of variation and binding with high specificity to a broad spectrum of targets. The snake toxin domain is present in short and long neurotoxins, cytotoxins, and short toxins, and in other miscellaneous venom peptides. The toxin acts by binding to the nicotinic acetylcholine receptors in the postsynaptic membrane of skeletal muscles and preventing the binding of acetylcholine, thereby blocking the excitation of muscles. Both the LU-like ECD and the snake toxin domain belong to three-fingered protein (TFP) fold, which is characterized by containing 70 to 100 amino acids including eight to ten cysteine residues spaced at conserved distances.


The actual alignment was detected with superfamily member cd23556:

Pssm-ID: 480272  Cd Length: 79  Bit Score: 45.53  E-value: 7.38e-07
                          10        20        30
                  ....*....|....*....|....*....|....
gi 2217321603  23 LRCMQCKTNGDCRVEE-CALGQDLCRTTIVRLWE 55
Cdd:cd23556     1 LRCYSCKSNGDCRVEEvCALGQDLCRTTVMTLWE 34
 
Name Accession Description Interval E-value
TFP_LU_ECD_uPAR_rpt2 cd23557
second extracellular domain (ECD) found in urokinase plasminogen activator surface receptor ...
 63-151 4.17e-34

second extracellular domain (ECD) found in urokinase plasminogen activator surface receptor (uPAR) and similar proteins; uPAR (also called U-PAR, or monocyte activation antigen Mo3, or CD87) acts as a receptor for urokinase plasminogen activator. It plays a role in localizing and promoting plasmin formation. It mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form. uPAR contains three extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the second ECD.


Pssm-ID: 467087  Cd Length: 85  Bit Score: 117.42  E-value: 4.17e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217321603  63 RSRYLECISCGSSDMSCERGRHQSLQCRSPEEQCLDVVTHWIQegeeGRPKDDRHLRGCGYLPGCPGSNGFHNNDTFHFL 142
Cdd:cd23557     1 RSRYLECYSCGSSDMSCERGRLTSLQCRGPQDQCVDVTTHGSL----ERPKSERRLKGCGTLPGCPGSLGFHNNDTFHLL 76


                  ....*....
gi 2217321603 143 KCCNTTKCN 151
Cdd:cd23557    77 KCCNSSLCN 85
LU smart00134
Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type ...
 67-154 5.08e-15

Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type plasminogen activator receptor; occurs singly in other GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2). Topology of these domains is similar to that of snake venom neurotoxins.


Pssm-ID: 214530  Cd Length: 85  Bit Score: 67.94  E-value: 5.08e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217321603   67 LECISC-GSSDMSCERGRHqslqCRSPEEQCLDVVTHWIQEGeegrpKDDRHLRGCGYLPGCPGSNGFHNNDTFHFLK-- 143
Cdd:smart00134   1 LQCYSCtGNPDSSCSSEEE----CRSPDDVCLTVVAEVISDS-----RGSVVYKGCATSPICPGSHGYEINLTIAFLKvs 71

                           90
                   ....*....|.
gi 2217321603  144 CCNTTKCNEGP 154
Cdd:smart00134  72 CCQTDLCNAAG 82
TFP_LU_ECD_uPAR_rpt3 cd23558
third extracellular domain (ECD) found in urokinase plasminogen activator surface receptor ...
 159-209 4.70e-13

third extracellular domain (ECD) found in urokinase plasminogen activator surface receptor (uPAR) and similar proteins; uPAR (also called U-PAR, or monocyte activation antigen Mo3, or CD87) acts as a receptor for urokinase plasminogen activator. It plays a role in localizing and promoting plasmin formation. It mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form. uPAR contains three extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the third ECD.


Pssm-ID: 467088  Cd Length: 93  Bit Score: 62.80  E-value: 4.70e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2217321603 159 ENLPQNGRQCYSCKGNSTHGCSSEETFLIDCRGPMNQCLVATGTHERSLWG 209
Cdd:cd23558     1 PDLPPNGIQCYSCNGNSTHGCSSEETSKVRCRGPQTQCLEATGTTAHGGKN 51
TFP_LU_ECD_uPAR_rpt1 cd23556
first extracellular domain (ECD) found in urokinase plasminogen activator surface receptor ...
 23-55 7.38e-07

first extracellular domain (ECD) found in urokinase plasminogen activator surface receptor (uPAR) and similar proteins; uPAR (also called U-PAR, or monocyte activation antigen Mo3, or CD87) acts as a receptor for urokinase plasminogen activator. It plays a role in localizing and promoting plasmin formation. It mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form. uPAR contains three extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the first ECD.


Pssm-ID: 467086  Cd Length: 79  Bit Score: 45.53  E-value: 7.38e-07
                          10        20        30
                  ....*....|....*....|....*....|....
gi 2217321603  23 LRCMQCKTNGDCRVEE-CALGQDLCRTTIVRLWE 55
Cdd:cd23556     1 LRCYSCKSNGDCRVEEvCALGQDLCRTTVMTLWE 34
LU smart00134
Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type ...
 166-204 4.24e-04

Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type plasminogen activator receptor; occurs singly in other GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2). Topology of these domains is similar to that of snake venom neurotoxins.


Pssm-ID: 214530  Cd Length: 85  Bit Score: 38.28  E-value: 4.24e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 2217321603  166 RQCYSCKGNSTHGCSSEETflidCRGPMNQCLVATGTHE 204
Cdd:smart00134   1 LQCYSCTGNPDSSCSSEEE----CRSPDDVCLTVVAEVI 35
UPAR_LY6 pfam00021
u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.
 168-203 1.55e-03

u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.


Pssm-ID: 394978  Cd Length: 77  Bit Score: 36.36  E-value: 1.55e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 2217321603 168 CYSCKGNSTHGCSSEETflidCRGPMNQCLVATGTH 203
Cdd:pfam00021   1 CYSCLGVSNEDCLSEVT----CPLSDGQCVTTTLEL 32
 
Name Accession Description Interval E-value
TFP_LU_ECD_uPAR_rpt2 cd23557
second extracellular domain (ECD) found in urokinase plasminogen activator surface receptor ...
 63-151 4.17e-34

second extracellular domain (ECD) found in urokinase plasminogen activator surface receptor (uPAR) and similar proteins; uPAR (also called U-PAR, or monocyte activation antigen Mo3, or CD87) acts as a receptor for urokinase plasminogen activator. It plays a role in localizing and promoting plasmin formation. It mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form. uPAR contains three extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the second ECD.


Pssm-ID: 467087  Cd Length: 85  Bit Score: 117.42  E-value: 4.17e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217321603  63 RSRYLECISCGSSDMSCERGRHQSLQCRSPEEQCLDVVTHWIQegeeGRPKDDRHLRGCGYLPGCPGSNGFHNNDTFHFL 142
Cdd:cd23557     1 RSRYLECYSCGSSDMSCERGRLTSLQCRGPQDQCVDVTTHGSL----ERPKSERRLKGCGTLPGCPGSLGFHNNDTFHLL 76


                  ....*....
gi 2217321603 143 KCCNTTKCN 151
Cdd:cd23557    77 KCCNSSLCN 85
LU smart00134
Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type ...
 67-154 5.08e-15

Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type plasminogen activator receptor; occurs singly in other GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2). Topology of these domains is similar to that of snake venom neurotoxins.


Pssm-ID: 214530  Cd Length: 85  Bit Score: 67.94  E-value: 5.08e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217321603   67 LECISC-GSSDMSCERGRHqslqCRSPEEQCLDVVTHWIQEGeegrpKDDRHLRGCGYLPGCPGSNGFHNNDTFHFLK-- 143
Cdd:smart00134   1 LQCYSCtGNPDSSCSSEEE----CRSPDDVCLTVVAEVISDS-----RGSVVYKGCATSPICPGSHGYEINLTIAFLKvs 71

                           90
                   ....*....|.
gi 2217321603  144 CCNTTKCNEGP 154
Cdd:smart00134  72 CCQTDLCNAAG 82
TFP_LU_ECD_uPAR_rpt3 cd23558
third extracellular domain (ECD) found in urokinase plasminogen activator surface receptor ...
 159-209 4.70e-13

third extracellular domain (ECD) found in urokinase plasminogen activator surface receptor (uPAR) and similar proteins; uPAR (also called U-PAR, or monocyte activation antigen Mo3, or CD87) acts as a receptor for urokinase plasminogen activator. It plays a role in localizing and promoting plasmin formation. It mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form. uPAR contains three extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the third ECD.


Pssm-ID: 467088  Cd Length: 93  Bit Score: 62.80  E-value: 4.70e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2217321603 159 ENLPQNGRQCYSCKGNSTHGCSSEETFLIDCRGPMNQCLVATGTHERSLWG 209
Cdd:cd23558     1 PDLPPNGIQCYSCNGNSTHGCSSEETSKVRCRGPQTQCLEATGTTAHGGKN 51
TFP_LU_ECD_uPAR_rpt1 cd23556
first extracellular domain (ECD) found in urokinase plasminogen activator surface receptor ...
 23-55 7.38e-07

first extracellular domain (ECD) found in urokinase plasminogen activator surface receptor (uPAR) and similar proteins; uPAR (also called U-PAR, or monocyte activation antigen Mo3, or CD87) acts as a receptor for urokinase plasminogen activator. It plays a role in localizing and promoting plasmin formation. It mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form. uPAR contains three extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the first ECD.


Pssm-ID: 467086  Cd Length: 79  Bit Score: 45.53  E-value: 7.38e-07
                          10        20        30
                  ....*....|....*....|....*....|....
gi 2217321603  23 LRCMQCKTNGDCRVEE-CALGQDLCRTTIVRLWE 55
Cdd:cd23556     1 LRCYSCKSNGDCRVEEvCALGQDLCRTTVMTLWE 34
TFP_LU_ECD_LYPD5_rpt2 cd23566
second extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 5 (LYPD5) and ...
 162-204 1.98e-04

second extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 5 (LYPD5) and similar proteins; LYPD5 (also called Haldisin (human antigen with LU-domains expressed in skin)) is a novel differentiation marker of stratum granulosum in squamous epithelia. LYPD5 contains two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the second ECD.


Pssm-ID: 467096  Cd Length: 96  Bit Score: 39.31  E-value: 1.98e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 2217321603 162 PQNGRQCYSCKGNSTHGCSSEETFLIDCRGPMNQCLVATGTHE 204
Cdd:cd23566     5 TPNGMECYACLSFSPDDCSPENAEKVKCHGDMTRCYEGNGTVT 47
LU smart00134
Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type ...
 166-204 4.24e-04

Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type plasminogen activator receptor; occurs singly in other GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2). Topology of these domains is similar to that of snake venom neurotoxins.


Pssm-ID: 214530  Cd Length: 85  Bit Score: 38.28  E-value: 4.24e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 2217321603  166 RQCYSCKGNSTHGCSSEETflidCRGPMNQCLVATGTHE 204
Cdd:smart00134   1 LQCYSCTGNPDSSCSSEEE----CRSPDDVCLTVVAEVI 35
UPAR_LY6 pfam00021
u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.
 168-203 1.55e-03

u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.


Pssm-ID: 394978  Cd Length: 77  Bit Score: 36.36  E-value: 1.55e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 2217321603 168 CYSCKGNSTHGCSSEETflidCRGPMNQCLVATGTH 203
Cdd:pfam00021   1 CYSCLGVSNEDCLSEVT----CPLSDGQCVTTTLEL 32
TFP_LU_ECD_PINLYP_rpt2 cd23572
second extracellular domain (ECD) found in phospholipase A2 inhibitor and Ly6/PLAUR ...
 164-206 3.46e-03

second extracellular domain (ECD) found in phospholipase A2 inhibitor and Ly6/PLAUR domain-containing protein (PINLYP) and similar proteins; PINLYP is a cytotoxic necrotizing factor (CNF)-like-inhibitor family protein which is the paralog of Ly6/PLAUR domain-containing protein 8 (LYPD8), a highly glycosylated glycosylphosphatidylinositol-anchored secreted protein that mediates segregation of intestinal bacteria and epithelial cells in the colon to preserve intestinal homeostasis. PINLYP contains two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the second ECD.


Pssm-ID: 467102  Cd Length: 80  Bit Score: 35.48  E-value: 3.46e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 2217321603 164 NGRQCYSCKGNSTHGCSSEETflIDCRGPMNQCLVATGTHERS 206
Cdd:cd23572     1 NGLQCPACYSEGSDSCKSEET--VNCTGEETQCIEFSGTISGG 41
TFP_LU_ECD_uPAR_rpt3 cd23558
third extracellular domain (ECD) found in urokinase plasminogen activator surface receptor ...
 67-153 4.11e-03

third extracellular domain (ECD) found in urokinase plasminogen activator surface receptor (uPAR) and similar proteins; uPAR (also called U-PAR, or monocyte activation antigen Mo3, or CD87) acts as a receptor for urokinase plasminogen activator. It plays a role in localizing and promoting plasmin formation. It mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form. uPAR contains three extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the third ECD.


Pssm-ID: 467088  Cd Length: 93  Bit Score: 35.45  E-value: 4.11e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217321603  67 LECISC-GSSDMSCERGRHQSLQCRSPEEQCLDVVTHWIQEGEEGRPKddrhLRGCGYLPGCPGS----NGFHNNDTFHf 141
Cdd:cd23558     8 IQCYSCnGNSTHGCSSEETSKVRCRGPQTQCLEATGTTAHGGKNQSYM----VKGCATPSMCQSTalslNQVLNSADVR- 82

                          90
                  ....*....|..
gi 2217321603 142 lkCCNTTKCNEG 153
Cdd:cd23558    83 --CCNGSLCNNG 92
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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