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Conserved domains on  [gi|2217339486|ref|XP_047297264|]
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TBC1 domain family member 22A isoform X9 [Homo sapiens]

Protein Classification

TBC domain-containing protein( domain architecture ID 771)

TBC (Tre-2, BUB2p, Cdc16p) domain-containing protein may perform a GTP-activator activity on Rab-like GTPases

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TBC super family cl47029
Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; Widespread domain present in Gyp6 and ...
 219-333 7.47e-18

Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases.


The actual alignment was detected with superfamily member smart00164:

Pssm-ID: 214540 [Multi-domain]  Cd Length: 216  Bit Score: 81.20  E-value: 7.47e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217339486  219 SWSGIPKPVRPMTWKLLSGYLPANvdrrpatLQRKQKEYFAFIEHYYDSRNDEVHQdtyrqIHIDIPRMSPEALILQ--- 295
Cdd:smart00164   1 VRKGVPPSLRGVVWKLLLNAQPMD-------TSADKDLYSRLLKETAPDDKSIVHQ-----IEKDLRRTFPEHSFFQdke 68

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 2217339486  296 PKVTEIFERILFIWAIRHPASGYVQGINDLVTPFFVVF 333
Cdd:smart00164  69 GPGQESLRRVLKAYALYNPEVGYCQGMNFLAAPLLLVM 106
 
Name Accession Description Interval E-value
TBC smart00164
Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; Widespread domain present in Gyp6 and ...
 219-333 7.47e-18

Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases.


Pssm-ID: 214540 [Multi-domain]  Cd Length: 216  Bit Score: 81.20  E-value: 7.47e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217339486  219 SWSGIPKPVRPMTWKLLSGYLPANvdrrpatLQRKQKEYFAFIEHYYDSRNDEVHQdtyrqIHIDIPRMSPEALILQ--- 295
Cdd:smart00164   1 VRKGVPPSLRGVVWKLLLNAQPMD-------TSADKDLYSRLLKETAPDDKSIVHQ-----IEKDLRRTFPEHSFFQdke 68

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 2217339486  296 PKVTEIFERILFIWAIRHPASGYVQGINDLVTPFFVVF 333
Cdd:smart00164  69 GPGQESLRRVLKAYALYNPEVGYCQGMNFLAAPLLLVM 106
COG5210 COG5210
GTPase-activating protein [General function prediction only];
211-333 3.00e-15

GTPase-activating protein [General function prediction only];


Pssm-ID: 227535 [Multi-domain]  Cd Length: 496  Bit Score: 76.76  E-value: 3.00e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217339486 211 DLEELRRLSWSGIPKPVRPMTWKLLSGYLPaNVDRRPATLQRKQKEYFAFIEHYYDSRndevhqdtyRQIHIDIPRMSPE 290
Cdd:COG5210   201 QLSKLRELIRKGIPNELRGDVWEFLLGIGF-DLDKNPGLYERLLNLHREAKIPTQEII---------SQIEKDLSRTFPD 270

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 2217339486 291 ALILQPKVT---EIFERILFIWAIRHPASGYVQGINDLVTPFFVVF 333
Cdd:COG5210   271 NSLFQTEISiraENLRRVLKAYSLYNPEVGYVQGMNFLAAPLLLVL 316
RabGAP-TBC pfam00566
Rab-GTPase-TBC domain; Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are ...
 279-337 7.58e-10

Rab-GTPase-TBC domain; Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are GTPase activator proteins of yeast Ypt6 and Ypt7, implies that these domains are GTPase activator proteins of Rab-like small GTPases.


Pssm-ID: 459855  Cd Length: 178  Bit Score: 57.65  E-value: 7.58e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217339486 279 QIHIDIPRMSPEALILQPKVTEI-FERILFIWAIRHPASGYVQGINDLVTPFFVVFICEY 337
Cdd:pfam00566  11 QIEKDVPRTFPHSFFFDNGPGQNsLRRILKAYSIYNPDVGYCQGMNFIAAPLLLVYLDEE 70
 
Name Accession Description Interval E-value
TBC smart00164
Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; Widespread domain present in Gyp6 and ...
 219-333 7.47e-18

Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases.


Pssm-ID: 214540 [Multi-domain]  Cd Length: 216  Bit Score: 81.20  E-value: 7.47e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217339486  219 SWSGIPKPVRPMTWKLLSGYLPANvdrrpatLQRKQKEYFAFIEHYYDSRNDEVHQdtyrqIHIDIPRMSPEALILQ--- 295
Cdd:smart00164   1 VRKGVPPSLRGVVWKLLLNAQPMD-------TSADKDLYSRLLKETAPDDKSIVHQ-----IEKDLRRTFPEHSFFQdke 68

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 2217339486  296 PKVTEIFERILFIWAIRHPASGYVQGINDLVTPFFVVF 333
Cdd:smart00164  69 GPGQESLRRVLKAYALYNPEVGYCQGMNFLAAPLLLVM 106
COG5210 COG5210
GTPase-activating protein [General function prediction only];
211-333 3.00e-15

GTPase-activating protein [General function prediction only];


Pssm-ID: 227535 [Multi-domain]  Cd Length: 496  Bit Score: 76.76  E-value: 3.00e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217339486 211 DLEELRRLSWSGIPKPVRPMTWKLLSGYLPaNVDRRPATLQRKQKEYFAFIEHYYDSRndevhqdtyRQIHIDIPRMSPE 290
Cdd:COG5210   201 QLSKLRELIRKGIPNELRGDVWEFLLGIGF-DLDKNPGLYERLLNLHREAKIPTQEII---------SQIEKDLSRTFPD 270

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 2217339486 291 ALILQPKVT---EIFERILFIWAIRHPASGYVQGINDLVTPFFVVF 333
Cdd:COG5210   271 NSLFQTEISiraENLRRVLKAYSLYNPEVGYVQGMNFLAAPLLLVL 316
RabGAP-TBC pfam00566
Rab-GTPase-TBC domain; Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are ...
 279-337 7.58e-10

Rab-GTPase-TBC domain; Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are GTPase activator proteins of yeast Ypt6 and Ypt7, implies that these domains are GTPase activator proteins of Rab-like small GTPases.


Pssm-ID: 459855  Cd Length: 178  Bit Score: 57.65  E-value: 7.58e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217339486 279 QIHIDIPRMSPEALILQPKVTEI-FERILFIWAIRHPASGYVQGINDLVTPFFVVFICEY 337
Cdd:pfam00566  11 QIEKDVPRTFPHSFFFDNGPGQNsLRRILKAYSIYNPDVGYCQGMNFIAAPLLLVYLDEE 70
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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