NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2217327904|ref|XP_047300245|]
View 

AF4/FMR2 family member 3 isoform X17 [Homo sapiens]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
AF-4_C pfam18876
AF-4 proto-oncoprotein C-terminal region; This family consists of AF4 (Proto-oncogene AF4) and ...
 633-877 5.76e-129

AF-4 proto-oncoprotein C-terminal region; This family consists of AF4 (Proto-oncogene AF4) and FMR2 (Fragile X E mental retardation syndrome) nuclear proteins. These proteins have been linked to human diseases such as acute lymphoblastic leukaemia and mental retardation. The family also contains a Drosophila AF4 protein homolog Lilliputian which contains an AT-hook domain. Lilliputian represents a novel pair-rule gene that acts in cytoskeleton regulation, segmentation and morphogenesis in Drosophila.


:

Pssm-ID: 465894  Cd Length: 262  Bit Score: 387.49  E-value: 5.76e-129
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217327904 633 RQKLVFDDMPRSADYFMQEAKRMKHKADAMVEKFGKALNYAEAALSFIECGNAMEQGPMESKSPYTMYSETVELIRYAMR 712
Cdd:pfam18876   5 RPQLKFEDRQHSADYYMQEAKKLKHKADALSDKFGKAFKYLDAALSFIECGIAMESDPQEAKSPYTMYSETVELIKYVMK 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217327904 713 LKTHSGPNATPEDKQLAALCYRCLALLYWRMFRLKRDHAVKYSKALIDYFKNSSKAAQAPSPWGA--------------S 778
Cdd:pfam18876  85 LKNFTDPSATTAEKIFAVLCLRCQSLLYMAMFRLKKDTAIKYSRTLNEHFKNSSKVAQAPSPCVAkstgtpsplspmpsP 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217327904 779 GNSVGSQGSLSNASALSPStiVSIPQRIHQMAANHVSITNSILHSYDYWEMADNLAKENREFFNDLDLLMGPVTLHSSME 858
Cdd:pfam18876 165 ASSVSSQSGSSGSSGSSSS--VSIPQRIHQMASSYVNITSNFLYAYEIWEQAEALARENKEFFAELDTVMGPLALNSSMT 242

                         250
                  ....*....|....*....
gi 2217327904 859 HLVQYSQQGLHWLRNSAHL 877
Cdd:pfam18876 243 ELVRYTRQGLHWLRLDAKL 261
AF-4 super family cl25851
AF-4 proto-oncoprotein N-terminal region; This family consists of AF4 (Proto-oncogene AF4) and ...
 28-141 1.67e-11

AF-4 proto-oncoprotein N-terminal region; This family consists of AF4 (Proto-oncogene AF4) and FMR2 (Fragile X E mental retardation syndrome) nuclear proteins. These proteins have been linked to human diseases such as acute lymphoblastic leukaemia and mental retardation. The family also contains a Drosophila AF4 protein homolog Lilliputian which contains an AT-hook domain. Lilliputian represents a novel pair-rule gene that acts in cytoskeleton regulation, segmentation and morphogenesis in Drosophila.


The actual alignment was detected with superfamily member pfam05110:

Pssm-ID: 461550 [Multi-domain]  Cd Length: 514  Bit Score: 67.46  E-value: 1.67e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217327904  28 SQPSSGMLEDDLKLSSDEEENE-QAAQRTALRALSDSAVVQQPNcrtsvpssKGSSSSSSSGSSSSSSDSESSSGSDSET 106
Cdd:pfam05110 408 SQQGTSMLEDDLKLSSSEDSDDdQAPEKPPPSSAPPSAPQSQPN--------SVASAHSSSGESGSSSDSESSSESDSES 479

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 2217327904 107 ESSSSESEGSKPPHFSSPEAEPASSNKWQLDKWLN 141
Cdd:pfam05110 480 ESSSSDSEANEPPRSATPEPEPPSSNKWQLDNWLN 514
AF4_int pfam18875
AF4 interaction motif; This short motif found in the AF4 protein interacts with AF9.
 434-447 1.17e-03

AF4 interaction motif; This short motif found in the AF4 protein interacts with AF9.


:

Pssm-ID: 436798  Cd Length: 15  Bit Score: 37.02  E-value: 1.17e-03
                          10
                  ....*....|....
gi 2217327904 434 LWVKIDLTLLSRIP 447
Cdd:pfam18875   1 LVVKIDLSLLSRVP 14
 
Name Accession Description Interval E-value
AF-4_C pfam18876
AF-4 proto-oncoprotein C-terminal region; This family consists of AF4 (Proto-oncogene AF4) and ...
 633-877 5.76e-129

AF-4 proto-oncoprotein C-terminal region; This family consists of AF4 (Proto-oncogene AF4) and FMR2 (Fragile X E mental retardation syndrome) nuclear proteins. These proteins have been linked to human diseases such as acute lymphoblastic leukaemia and mental retardation. The family also contains a Drosophila AF4 protein homolog Lilliputian which contains an AT-hook domain. Lilliputian represents a novel pair-rule gene that acts in cytoskeleton regulation, segmentation and morphogenesis in Drosophila.


Pssm-ID: 465894  Cd Length: 262  Bit Score: 387.49  E-value: 5.76e-129
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217327904 633 RQKLVFDDMPRSADYFMQEAKRMKHKADAMVEKFGKALNYAEAALSFIECGNAMEQGPMESKSPYTMYSETVELIRYAMR 712
Cdd:pfam18876   5 RPQLKFEDRQHSADYYMQEAKKLKHKADALSDKFGKAFKYLDAALSFIECGIAMESDPQEAKSPYTMYSETVELIKYVMK 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217327904 713 LKTHSGPNATPEDKQLAALCYRCLALLYWRMFRLKRDHAVKYSKALIDYFKNSSKAAQAPSPWGA--------------S 778
Cdd:pfam18876  85 LKNFTDPSATTAEKIFAVLCLRCQSLLYMAMFRLKKDTAIKYSRTLNEHFKNSSKVAQAPSPCVAkstgtpsplspmpsP 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217327904 779 GNSVGSQGSLSNASALSPStiVSIPQRIHQMAANHVSITNSILHSYDYWEMADNLAKENREFFNDLDLLMGPVTLHSSME 858
Cdd:pfam18876 165 ASSVSSQSGSSGSSGSSSS--VSIPQRIHQMASSYVNITSNFLYAYEIWEQAEALARENKEFFAELDTVMGPLALNSSMT 242

                         250
                  ....*....|....*....
gi 2217327904 859 HLVQYSQQGLHWLRNSAHL 877
Cdd:pfam18876 243 ELVRYTRQGLHWLRLDAKL 261
AF-4 pfam05110
AF-4 proto-oncoprotein N-terminal region; This family consists of AF4 (Proto-oncogene AF4) and ...
 28-141 1.67e-11

AF-4 proto-oncoprotein N-terminal region; This family consists of AF4 (Proto-oncogene AF4) and FMR2 (Fragile X E mental retardation syndrome) nuclear proteins. These proteins have been linked to human diseases such as acute lymphoblastic leukaemia and mental retardation. The family also contains a Drosophila AF4 protein homolog Lilliputian which contains an AT-hook domain. Lilliputian represents a novel pair-rule gene that acts in cytoskeleton regulation, segmentation and morphogenesis in Drosophila.


Pssm-ID: 461550 [Multi-domain]  Cd Length: 514  Bit Score: 67.46  E-value: 1.67e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217327904  28 SQPSSGMLEDDLKLSSDEEENE-QAAQRTALRALSDSAVVQQPNcrtsvpssKGSSSSSSSGSSSSSSDSESSSGSDSET 106
Cdd:pfam05110 408 SQQGTSMLEDDLKLSSSEDSDDdQAPEKPPPSSAPPSAPQSQPN--------SVASAHSSSGESGSSSDSESSSESDSES 479

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 2217327904 107 ESSSSESEGSKPPHFSSPEAEPASSNKWQLDKWLN 141
Cdd:pfam05110 480 ESSSSDSEANEPPRSATPEPEPPSSNKWQLDNWLN 514
AF4_int pfam18875
AF4 interaction motif; This short motif found in the AF4 protein interacts with AF9.
 434-447 1.17e-03

AF4 interaction motif; This short motif found in the AF4 protein interacts with AF9.


Pssm-ID: 436798  Cd Length: 15  Bit Score: 37.02  E-value: 1.17e-03
                          10
                  ....*....|....
gi 2217327904 434 LWVKIDLTLLSRIP 447
Cdd:pfam18875   1 LVVKIDLSLLSRVP 14
 
Name Accession Description Interval E-value
AF-4_C pfam18876
AF-4 proto-oncoprotein C-terminal region; This family consists of AF4 (Proto-oncogene AF4) and ...
 633-877 5.76e-129

AF-4 proto-oncoprotein C-terminal region; This family consists of AF4 (Proto-oncogene AF4) and FMR2 (Fragile X E mental retardation syndrome) nuclear proteins. These proteins have been linked to human diseases such as acute lymphoblastic leukaemia and mental retardation. The family also contains a Drosophila AF4 protein homolog Lilliputian which contains an AT-hook domain. Lilliputian represents a novel pair-rule gene that acts in cytoskeleton regulation, segmentation and morphogenesis in Drosophila.


Pssm-ID: 465894  Cd Length: 262  Bit Score: 387.49  E-value: 5.76e-129
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217327904 633 RQKLVFDDMPRSADYFMQEAKRMKHKADAMVEKFGKALNYAEAALSFIECGNAMEQGPMESKSPYTMYSETVELIRYAMR 712
Cdd:pfam18876   5 RPQLKFEDRQHSADYYMQEAKKLKHKADALSDKFGKAFKYLDAALSFIECGIAMESDPQEAKSPYTMYSETVELIKYVMK 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217327904 713 LKTHSGPNATPEDKQLAALCYRCLALLYWRMFRLKRDHAVKYSKALIDYFKNSSKAAQAPSPWGA--------------S 778
Cdd:pfam18876  85 LKNFTDPSATTAEKIFAVLCLRCQSLLYMAMFRLKKDTAIKYSRTLNEHFKNSSKVAQAPSPCVAkstgtpsplspmpsP 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217327904 779 GNSVGSQGSLSNASALSPStiVSIPQRIHQMAANHVSITNSILHSYDYWEMADNLAKENREFFNDLDLLMGPVTLHSSME 858
Cdd:pfam18876 165 ASSVSSQSGSSGSSGSSSS--VSIPQRIHQMASSYVNITSNFLYAYEIWEQAEALARENKEFFAELDTVMGPLALNSSMT 242

                         250
                  ....*....|....*....
gi 2217327904 859 HLVQYSQQGLHWLRNSAHL 877
Cdd:pfam18876 243 ELVRYTRQGLHWLRLDAKL 261
AF-4 pfam05110
AF-4 proto-oncoprotein N-terminal region; This family consists of AF4 (Proto-oncogene AF4) and ...
 28-141 1.67e-11

AF-4 proto-oncoprotein N-terminal region; This family consists of AF4 (Proto-oncogene AF4) and FMR2 (Fragile X E mental retardation syndrome) nuclear proteins. These proteins have been linked to human diseases such as acute lymphoblastic leukaemia and mental retardation. The family also contains a Drosophila AF4 protein homolog Lilliputian which contains an AT-hook domain. Lilliputian represents a novel pair-rule gene that acts in cytoskeleton regulation, segmentation and morphogenesis in Drosophila.


Pssm-ID: 461550 [Multi-domain]  Cd Length: 514  Bit Score: 67.46  E-value: 1.67e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217327904  28 SQPSSGMLEDDLKLSSDEEENE-QAAQRTALRALSDSAVVQQPNcrtsvpssKGSSSSSSSGSSSSSSDSESSSGSDSET 106
Cdd:pfam05110 408 SQQGTSMLEDDLKLSSSEDSDDdQAPEKPPPSSAPPSAPQSQPN--------SVASAHSSSGESGSSSDSESSSESDSES 479

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 2217327904 107 ESSSSESEGSKPPHFSSPEAEPASSNKWQLDKWLN 141
Cdd:pfam05110 480 ESSSSDSEANEPPRSATPEPEPPSSNKWQLDNWLN 514
AF4_int pfam18875
AF4 interaction motif; This short motif found in the AF4 protein interacts with AF9.
 434-447 1.17e-03

AF4 interaction motif; This short motif found in the AF4 protein interacts with AF9.


Pssm-ID: 436798  Cd Length: 15  Bit Score: 37.02  E-value: 1.17e-03
                          10
                  ....*....|....
gi 2217327904 434 LWVKIDLTLLSRIP 447
Cdd:pfam18875   1 LVVKIDLSLLSRVP 14
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH