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Conserved domains on  [gi|2217330361|ref|XP_047301519|]
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aquaporin-12B isoform X9 [Homo sapiens]

Protein Classification

MIP/aquaporin family protein( domain architecture ID 1903731)

MIP (Major Intrinsic Protein)/aquaporin family protein similar to aquaporin that permits osmotically driven movement of water in both directions, and glycerol uptake facilitator protein that mediates glycerol diffusion across the cytoplasmic membrane via a pore-type mechanism

CATH:  1.20.1080.10
Gene Ontology:  GO:0055085|GO:0015267
PubMed:  11964478|8849412|11473620
SCOP:  3000508
TCDB:  1.A.8

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GlpF super family cl43193
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
 128-216 1.98e-04

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


The actual alignment was detected with superfamily member COG0580:

Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 42.04  E-value: 1.98e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217330361 128 SSALRTSVPHGALVEAACAFCFHLTLLHL---RHSPPAYSGPAVALLVTVTAYTAGPFTSAFFNPA--LA-ASVTFACSG 201
Cdd:COG0580   123 SPAIGYSLGAAFLTEIIGTFVLVFVILGItdkRAAPGGLAPLAIGLLVAAIGLSLGPLTGYAINPArdLGpRLFHALGKG 202

                          90
                  ....*....|....*
gi 2217330361 202 HTLLEYVQVYWLGPL 216
Cdd:COG0580   203 GSDWGYLWVPIVAPI 217
 
Name Accession Description Interval E-value
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
 128-216 1.98e-04

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 42.04  E-value: 1.98e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217330361 128 SSALRTSVPHGALVEAACAFCFHLTLLHL---RHSPPAYSGPAVALLVTVTAYTAGPFTSAFFNPA--LA-ASVTFACSG 201
Cdd:COG0580   123 SPAIGYSLGAAFLTEIIGTFVLVFVILGItdkRAAPGGLAPLAIGLLVAAIGLSLGPLTGYAINPArdLGpRLFHALGKG 202

                          90
                  ....*....|....*
gi 2217330361 202 HTLLEYVQVYWLGPL 216
Cdd:COG0580   203 GSDWGYLWVPIVAPI 217
MIP cd00333
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 92-216 3.87e-04

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


Pssm-ID: 238204  Cd Length: 228  Bit Score: 41.09  E-value: 3.87e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217330361  92 AAQGLGMQAACTLTRLCWA---WELSDLHLLQSLMAQSCSSALRTSVpHGALVEAACAFCFHLTLLHL----RHSPPAYS 164
Cdd:cd00333    84 IAQLLGAILGAALLYGLYYglyLEFLGANNIVAGIFGTYPSPGVSNG-NAFFVEFIGTFILVLVVFATtddpNGPPPGGL 162

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2217330361 165 GP-AVALLVTVTAYTAGPFTSAFFNPALAASVTFACSGHTLLEYVQVYWLGPL 216
Cdd:cd00333   163 APlAIGLLVAAIGLAGGPITGASMNPARSLGPALFTGLARHWHYFWVYWVGPL 215
 
Name Accession Description Interval E-value
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
 128-216 1.98e-04

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 42.04  E-value: 1.98e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217330361 128 SSALRTSVPHGALVEAACAFCFHLTLLHL---RHSPPAYSGPAVALLVTVTAYTAGPFTSAFFNPA--LA-ASVTFACSG 201
Cdd:COG0580   123 SPAIGYSLGAAFLTEIIGTFVLVFVILGItdkRAAPGGLAPLAIGLLVAAIGLSLGPLTGYAINPArdLGpRLFHALGKG 202

                          90
                  ....*....|....*
gi 2217330361 202 HTLLEYVQVYWLGPL 216
Cdd:COG0580   203 GSDWGYLWVPIVAPI 217
MIP cd00333
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 92-216 3.87e-04

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


Pssm-ID: 238204  Cd Length: 228  Bit Score: 41.09  E-value: 3.87e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217330361  92 AAQGLGMQAACTLTRLCWA---WELSDLHLLQSLMAQSCSSALRTSVpHGALVEAACAFCFHLTLLHL----RHSPPAYS 164
Cdd:cd00333    84 IAQLLGAILGAALLYGLYYglyLEFLGANNIVAGIFGTYPSPGVSNG-NAFFVEFIGTFILVLVVFATtddpNGPPPGGL 162

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2217330361 165 GP-AVALLVTVTAYTAGPFTSAFFNPALAASVTFACSGHTLLEYVQVYWLGPL 216
Cdd:cd00333   163 APlAIGLLVAAIGLAGGPITGASMNPARSLGPALFTGLARHWHYFWVYWVGPL 215
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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