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Conserved domains on  [gi|2217264810|ref|XP_047304549|]
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sodium/glucose cotransporter 4 isoform X6 [Homo sapiens]

Protein Classification

SLC5/6 family protein( domain architecture ID 124)

SLC5/6 (solute carrier 5/6) family protein may function as a transporter

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
SLC5-6-like_sbd super family cl00456
Solute carrier families 5 and 6-like; solute binding domain; This superfamily includes the ...
130-625 0e+00

Solute carrier families 5 and 6-like; solute binding domain; This superfamily includes the solute-binding domain of SLC5 proteins (also called the sodium/glucose cotransporters or solute sodium symporters), SLC6 proteins (also called the sodium- and chloride-dependent neurotransmitter transporters or Na+/Cl--dependent transporters), and nucleobase-cation-symport-1 (NCS1) transporters. SLC5s co-transport Na+ with sugars, amino acids, inorganic ions or vitamins. SLC6s include Na+/Cl--dependent plasma membrane transporters for the monoamine neurotransmitters serotonin, dopamine, and norepinephrine, and the amino acid neurotransmitters GABA and glycine. NCS1s are essential components of salvage pathways for nucleobases and related metabolites; their known substrates include allantoin, uracil, thiamine, and nicotinamide riboside. Members of this superfamily are important in human physiology and disease. They contain a functional core of 10 transmembrane helices (TMs): an inverted structural repeat, TMs1-5 and TMs6-10; TMs numbered to conform to the SLC6 Aquifex aeolicus LeuT.


The actual alignment was detected with superfamily member cd11488:

Pssm-ID: 444915  Cd Length: 605  Bit Score: 890.05  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 130 LHQDLGILLVVTAVYTIAGGLMAVIYTDALQTVIMVGGALVLMFLGFQDVGWYPGLEQRYRQAIPNVTVPNTTCHLPRPD 209
Cdd:cd11488   150 LYLSTVILLAVTALYTIAGGLTAVIYTDALQTVIMVIGAFVLMFIAFDKVGWYPGLEQQYEKAIPALTVPNTTCHLPRSD 229
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 210 AFHILRDPVSGDIPWPGLIFGLTVLATWCWCTDQVIVQRSLSAKSLSHAKGGSVLGGYLKILPMFFIVMPGMISRALFPD 289
Cdd:cd11488   230 AFHIFRDPVTGDIPWPGLIFGLTVLATWVWCTDQVIVQRSLSAKNLSHAKGGSVLGGYLKILPMFFVVMPGMISRALFPD 309
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 290 EVGCVDPDVCQRICGARVGCSNIAYPKLVMALMPVGLRGLMIAVIMAALMSSLTSIFNSSSTLFTIDVWQRFRRKSTEQE 369
Cdd:cd11488   310 EVGCVDPDECQKICGAKVGCSNIAYPKLVVELMPVGLRGLMIAVIMAALMSSLTSIFNSSSTLFTMDVWQRIRRRASEQE 389
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 370 LMVVGRVFVVFLVVISILWIPIIQSSNSGQLFDYIQAVTSYLAPPITALFLLAIFCKRVTEPGAFWGLVFGLGVGLLRMI 449
Cdd:cd11488   390 LMVVGRVFILLLVVISILWIPIIQTANSGQLFDYIQAVTSYLSPPITAVFILAIFWKRVNEPGAFWGLMVGLVVGLVRMI 469
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 450 LEFSYPAPACGEVDRRPAVLKDFHYLYFAILLCGLTAIVIVIVSLCTTPIPEEQLTRLTWWTRNCPLSELEKeahestpe 529
Cdd:cd11488   470 MEFVYGAPSCGETDLRPSVLKDVHYLYFAIILLGLTAIVIVAVSLCTAPIPEKHLVRLTWWTRNSPEERVEL-------- 541
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 530 iserpagecpagggaaensslgqeqpeapsrsWGKLLWSWFCGLSGTPEQALSPAEKAALEQKLTSIEEEPLWRHVCNIN 609
Cdd:cd11488   542 --------------------------------WWKRLGMWFCGLSQTPEQDLSEEERQALEKKLTSIEEDPLWRTVCNIN 589
                         490
                  ....*....|....*.
gi 2217264810 610 AVLLLAINIFLWGYFA 625
Cdd:cd11488   590 ALILLAINVFLWGYFA 605
 
Name Accession Description Interval E-value
SLC5sbd_SGLT4 cd11488
Na(+)/glucose cotransporter SGLT4 and related proteins; solute-binding domain; Human SGLT4 ...
130-625 0e+00

Na(+)/glucose cotransporter SGLT4 and related proteins; solute-binding domain; Human SGLT4 (hSGLT4) has been reported to be a low-affinity glucose transporter with unusual sugar selectivity: it transports D-mannose but not galactose or 3-O-methyl-D-glucoside. It is encoded by the SLC5A9 gene and is expressed in intestine, kidney, liver, brain, lung, trachea, uterus, and pancreas. hSLGT4 is predicted to contain 14 membrane-spanning regions. This subgroup belongs to the solute carrier 5 (SLC5 )transporter family.


Pssm-ID: 271380  Cd Length: 605  Bit Score: 890.05  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 130 LHQDLGILLVVTAVYTIAGGLMAVIYTDALQTVIMVGGALVLMFLGFQDVGWYPGLEQRYRQAIPNVTVPNTTCHLPRPD 209
Cdd:cd11488   150 LYLSTVILLAVTALYTIAGGLTAVIYTDALQTVIMVIGAFVLMFIAFDKVGWYPGLEQQYEKAIPALTVPNTTCHLPRSD 229
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 210 AFHILRDPVSGDIPWPGLIFGLTVLATWCWCTDQVIVQRSLSAKSLSHAKGGSVLGGYLKILPMFFIVMPGMISRALFPD 289
Cdd:cd11488   230 AFHIFRDPVTGDIPWPGLIFGLTVLATWVWCTDQVIVQRSLSAKNLSHAKGGSVLGGYLKILPMFFVVMPGMISRALFPD 309
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 290 EVGCVDPDVCQRICGARVGCSNIAYPKLVMALMPVGLRGLMIAVIMAALMSSLTSIFNSSSTLFTIDVWQRFRRKSTEQE 369
Cdd:cd11488   310 EVGCVDPDECQKICGAKVGCSNIAYPKLVVELMPVGLRGLMIAVIMAALMSSLTSIFNSSSTLFTMDVWQRIRRRASEQE 389
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 370 LMVVGRVFVVFLVVISILWIPIIQSSNSGQLFDYIQAVTSYLAPPITALFLLAIFCKRVTEPGAFWGLVFGLGVGLLRMI 449
Cdd:cd11488   390 LMVVGRVFILLLVVISILWIPIIQTANSGQLFDYIQAVTSYLSPPITAVFILAIFWKRVNEPGAFWGLMVGLVVGLVRMI 469
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 450 LEFSYPAPACGEVDRRPAVLKDFHYLYFAILLCGLTAIVIVIVSLCTTPIPEEQLTRLTWWTRNCPLSELEKeahestpe 529
Cdd:cd11488   470 MEFVYGAPSCGETDLRPSVLKDVHYLYFAIILLGLTAIVIVAVSLCTAPIPEKHLVRLTWWTRNSPEERVEL-------- 541
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 530 iserpagecpagggaaensslgqeqpeapsrsWGKLLWSWFCGLSGTPEQALSPAEKAALEQKLTSIEEEPLWRHVCNIN 609
Cdd:cd11488   542 --------------------------------WWKRLGMWFCGLSQTPEQDLSEEERQALEKKLTSIEEDPLWRTVCNIN 589
                         490
                  ....*....|....*.
gi 2217264810 610 AVLLLAINIFLWGYFA 625
Cdd:cd11488   590 ALILLAINVFLWGYFA 605
YidK COG4146
Uncharacterized membrane permease YidK, sodium:solute symporter family [General function ...
136-447 9.01e-103

Uncharacterized membrane permease YidK, sodium:solute symporter family [General function prediction only];


Pssm-ID: 443317 [Multi-domain]  Cd Length: 444  Bit Score: 319.01  E-value: 9.01e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 136 ILLVVTAVYTIAGGLMAVIYTDALQTVIMVGGALVLMFLGFQDVG---WYPGLEQRYRQAipnvtvpnttchlprPDAFH 212
Cdd:COG4146   161 GLGIIAGIYTIFGGLKAVAYTDVIQGIGLIIGGLLITVLGLDAVGdgsVLAGWSALLKVP---------------PEKFN 225
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 213 ILRDPVSGDIPWPGLIFGLTVLATWCWCTDQVIVQRSLSAKSLSHAKGGSVLGGYLKILPMFFIVMPGMISRALFPDEVg 292
Cdd:COG4146   226 MIGPADDPDLPWLGIFTGMPILNLFYWGTNQYIVQRALGAKNLKEAQKGVLFAGFLKLLIPFIVVLPGIIAFVLFPDGL- 304
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 293 cVDPDvcqricgarvgcsnIAYPKLVMALMPVGLRGLMIAVIMAALMSSLTSIFNSSSTLFTIDVWQRFRRK-STEQELM 371
Cdd:COG4146   305 -DNPD--------------QAYPTLVKNLLPVGLKGLVAAALFAAIMSSLASALNSSSTLFTLDIYKKYFNPnASEKQLV 369
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2217264810 372 VVGRVFVVFLVVISILWIPIIqsSNSGQLFDYIQAVTSYLAPPITALFLLAIFCKRVTEPGAFWGLVFGLGVGLLR 447
Cdd:COG4146   370 KVGRIATVVLAVIAILIAPLI--GNADGLFQYIQEVTGFFSPPILAVFLLGLFWKRVTAKAAKVALIAGIVLSILL 443
sss TIGR00813
transporter, SSS family; The Solute:Sodium Symporter (SSS) Family (TC 2.A.21) Members of the ...
130-440 9.01e-100

transporter, SSS family; The Solute:Sodium Symporter (SSS) Family (TC 2.A.21) Members of the SSS family catalyze solute:Na+ symport. The solutes transported may be sugars, amino acids, nucleosides, inositols, vitamins, urea or anions, depending on the system. Members of the SSS family have been identified in bacteria, archaea and animals, and all functionally well characterized members catalyze solute uptake via Na+ symport. Proteins of the SSS generally share a core of 13 TMSs, but different members of the family may have different numbers of TMSs. A 13 TMS topology with a periplasmic N-terminus and a cytoplasmic C-terminus has been experimentally determined for the proline:Na+ symporter, PutP, of E. coli. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273282 [Multi-domain]  Cd Length: 407  Bit Score: 310.00  E-value: 9.01e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 130 LHQDLGILLVVTAVYTIAGGLMAVIYTDALQTVIMVGGALVLMFLGFQDVGWYPGLEQRYRQAIPNVTvpnttchlPRPD 209
Cdd:TIGR00813 116 LYLSLLLLGAITILYTVFGGLKAVVWTDTIQAVIMILGTFILPVFAFSEVGGLGTFVEKASQAAPTNP--------SPDD 187
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 210 AFHILRDPVSGDIPWPGLIFGLTVLATWCWcTDQVIVQRSLSAKSLSHAKGGSVLGGYLKILPMFFIVMPGMISRALFPD 289
Cdd:TIGR00813 188 LYDFFRDPSTSDLPWGAGVFGLPHVALWYW-TNQVIVQRCLAAKSAKHAKKGCLISGVLKLLPMFGAVLPGLIARALYTD 266
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 290 evgcVDPDvcqrICGARVGCSNIAYPKLVMALMPVGLRGLMIAVIMAALMSSLTSIFNSSSTLFTIDVWQRFRRKSTEQE 369
Cdd:TIGR00813 267 ----IDPA----LAGAVNQNSDQAYPLLVQELMPPGLAGLFLAAILAAVMSTLSSQLNSASTVFTMDLYKKIIRPNASGE 338
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2217264810 370 LMVVGRVFVVFLVVISILWipIIQSSNSGQLFDYIQAVTSYLAPPITALFLLAIFCKRVTEPGAFWGLVFG 440
Cdd:TIGR00813 339 KKIVMRGRIAVLVAAVIAG--FVAAAQGGQVLQYVQEAFGGLGAPFLPVFLLGIFWKRMNAKGALAGMIAG 407
SSF pfam00474
Sodium:solute symporter family; This family includes Swiss:P33413 which is not in the Prosite ...
128-440 1.96e-99

Sodium:solute symporter family; This family includes Swiss:P33413 which is not in the Prosite entry. Membership of this family is supported by a significant blast score.


Pssm-ID: 109527 [Multi-domain]  Cd Length: 406  Bit Score: 309.27  E-value: 1.96e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 128 LHLHQDLGILLVVTAVYTIAGGLMAVIYTDALQTVIMVGGALVLMFLGFQDVGWYPGLEQRYRQAIPNVTvpnttcHLPR 207
Cdd:pfam00474 118 LNYYTAVLLLGALTAIYTFFGGFLAVSWTDTIQAVLMLFGTIILMIIVFHEVGGYSSAVEKYMTADPNGV------DLYT 191
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 208 PDAFHILRDPVSGDIPWPGLIFGLTVLatwcwctdQVIVQRSLSAKslshaKGGSVLGGYLKILPMFFIVMPGMISRALF 287
Cdd:pfam00474 192 PDGLHILRDPLTGLSLWPGLVLGTTGL--------PHILQRCLAAK-----DAKCIRCGVLILTPMFIIVMPGMISRGLF 258
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 288 PDEVGCVDPDVCqricGARVGCSNIAYPKLVMALMPVGLRGLMIAVIMAALMSSLTSIFNSSSTLFTIDVWQRFRRKSTE 367
Cdd:pfam00474 259 AIALAGANPRAC----GTVVGCSNIAYPTLAVKLGPPGLAGIMLAVMLAAIMSTLTSQLLSSSSAFTHDLYKNIRRKASA 334
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2217264810 368 QELMVVGRVFVVFLVVISILWIPIIQSSNSGqLFDYIQAVTSYLAPPITALFLLAIFCKRVTEPGAFWGLVFG 440
Cdd:pfam00474 335 TEKELVGRSRIIVLVVISLAILLAVQPAQMG-IAFLVQLAFAGLGSAFLPVILLAIFWKRVNEQGALWGMIIG 406
PRK10484 PRK10484
putative transporter; Provisional
124-493 1.64e-51

putative transporter; Provisional


Pssm-ID: 236699 [Multi-domain]  Cd Length: 523  Bit Score: 185.86  E-value: 1.64e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 124 VSHPLHLHQDLGILLVVT------AVYTIAGGLMAVIYTDALQTVIMVGGALVLMFLGFQDVG---WYPGLEQRYRQaip 194
Cdd:PRK10484  149 VSELLGISYGAAIWLLVWligiigAIYAVFGGLKAVAVSDTINGIGLLIGGLLVPVFGLIALGdgsFMQGLEQLTTV--- 225
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 195 nvtvpnttchlpRPDAFHILRDPVSgDIPWPGLIFGLTVLATWCWCTDQVIVQRSLSAKSLSHAKGGSVLGGYLKILPMF 274
Cdd:PRK10484  226 ------------HPEKLNSIGGATD-PVPFPTLFTGLILVNLFYWCTNQSIVQRALGAKNLAEGQKGALLAAFFKLLGPL 292
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 275 FIVMPGMISRALFPDEVGCVDpdvcqricgarvgcsnIAYPKLVMALMPVGLRGLMIAVIMAALMSSLTSIFNSSSTLFT 354
Cdd:PRK10484  293 ILVLPGIIAFHLYGDGLPNAD----------------MAYPTLVNDVLPVPLVGFFAAVLFGAILSTFNGFLNSASTLFS 356
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 355 IDVW-QRFRRKSTEQELMVVGRVFVVFLVVISILWIPIIQSSNSGqLFDYIQAVTSYLAPPITALFLLAIFCKRVTEPGA 433
Cdd:PRK10484  357 LDIYkPIINPNASEKQLVKVGKKFGFVLAIISMIVAPLIANAPQG-LYSYLQQLNGIYNVPILAIIIVGFFTKRVPALAA 435
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2217264810 434 FWGLVFGLGV-GLLRMILEFsypapacgevdrrpavlkDFHYLY-FAILLCgLTAIVIVIVS 493
Cdd:PRK10484  436 KVALGFGIILyIIINFVLKF------------------DIHFLYvLAILFV-INVVVMLIIG 478
 
Name Accession Description Interval E-value
SLC5sbd_SGLT4 cd11488
Na(+)/glucose cotransporter SGLT4 and related proteins; solute-binding domain; Human SGLT4 ...
130-625 0e+00

Na(+)/glucose cotransporter SGLT4 and related proteins; solute-binding domain; Human SGLT4 (hSGLT4) has been reported to be a low-affinity glucose transporter with unusual sugar selectivity: it transports D-mannose but not galactose or 3-O-methyl-D-glucoside. It is encoded by the SLC5A9 gene and is expressed in intestine, kidney, liver, brain, lung, trachea, uterus, and pancreas. hSLGT4 is predicted to contain 14 membrane-spanning regions. This subgroup belongs to the solute carrier 5 (SLC5 )transporter family.


Pssm-ID: 271380  Cd Length: 605  Bit Score: 890.05  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 130 LHQDLGILLVVTAVYTIAGGLMAVIYTDALQTVIMVGGALVLMFLGFQDVGWYPGLEQRYRQAIPNVTVPNTTCHLPRPD 209
Cdd:cd11488   150 LYLSTVILLAVTALYTIAGGLTAVIYTDALQTVIMVIGAFVLMFIAFDKVGWYPGLEQQYEKAIPALTVPNTTCHLPRSD 229
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 210 AFHILRDPVSGDIPWPGLIFGLTVLATWCWCTDQVIVQRSLSAKSLSHAKGGSVLGGYLKILPMFFIVMPGMISRALFPD 289
Cdd:cd11488   230 AFHIFRDPVTGDIPWPGLIFGLTVLATWVWCTDQVIVQRSLSAKNLSHAKGGSVLGGYLKILPMFFVVMPGMISRALFPD 309
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 290 EVGCVDPDVCQRICGARVGCSNIAYPKLVMALMPVGLRGLMIAVIMAALMSSLTSIFNSSSTLFTIDVWQRFRRKSTEQE 369
Cdd:cd11488   310 EVGCVDPDECQKICGAKVGCSNIAYPKLVVELMPVGLRGLMIAVIMAALMSSLTSIFNSSSTLFTMDVWQRIRRRASEQE 389
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 370 LMVVGRVFVVFLVVISILWIPIIQSSNSGQLFDYIQAVTSYLAPPITALFLLAIFCKRVTEPGAFWGLVFGLGVGLLRMI 449
Cdd:cd11488   390 LMVVGRVFILLLVVISILWIPIIQTANSGQLFDYIQAVTSYLSPPITAVFILAIFWKRVNEPGAFWGLMVGLVVGLVRMI 469
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 450 LEFSYPAPACGEVDRRPAVLKDFHYLYFAILLCGLTAIVIVIVSLCTTPIPEEQLTRLTWWTRNCPLSELEKeahestpe 529
Cdd:cd11488   470 MEFVYGAPSCGETDLRPSVLKDVHYLYFAIILLGLTAIVIVAVSLCTAPIPEKHLVRLTWWTRNSPEERVEL-------- 541
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 530 iserpagecpagggaaensslgqeqpeapsrsWGKLLWSWFCGLSGTPEQALSPAEKAALEQKLTSIEEEPLWRHVCNIN 609
Cdd:cd11488   542 --------------------------------WWKRLGMWFCGLSQTPEQDLSEEERQALEKKLTSIEEDPLWRTVCNIN 589
                         490
                  ....*....|....*.
gi 2217264810 610 AVLLLAINIFLWGYFA 625
Cdd:cd11488   590 ALILLAINVFLWGYFA 605
SLC5sbd_SGLT5 cd11489
Na(+)/glucose cotransporter SGLT5 and related proteins; solute-binding domain; Human SGLT5 is ...
136-625 0e+00

Na(+)/glucose cotransporter SGLT5 and related proteins; solute-binding domain; Human SGLT5 is a glucose transporter, which also transports galactose. It is encoded by the SLC5A10 gene, and is exclusively expressed in the renal cortex. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 212058  Cd Length: 604  Bit Score: 606.55  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 136 ILLVVTAVYTIAGGLMAVIYTDALQTVIMVGGALVLMFLGFQDVGWYPGLEQRYRQAIPNVTVPNTTCHLPRPDAFHILR 215
Cdd:cd11489   159 LMLVVTALYTIAGGLAAVIYTDALQTLIMVIGAVILTIKAFNQIGGYSNLEEAYLQAVPSKIIPNTTCHLPRADAMHLFR 238
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 216 DPVSGDIPWPGLIFGLTVLATWCWCTDQVIVQRSLSAKSLSHAKGGSVLGGYLKILPMFFIVMPGMISRALFPDEVGCVD 295
Cdd:cd11489   239 DPVTGDLPWTGMTFGLTIMATWYWCTDQVIVQRSLSARSLSHAKGGSILASYLKMLPMGLIIMPGMISRALFPDDVACVD 318
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 296 PDVCQRICGARVGCSNIAYPKLVMALMPVGLRGLMIAVIMAALMSSLTSIFNSSSTLFTIDVWQRFRRKSTEQELMVVGR 375
Cdd:cd11489   319 PEECLRVCGAEVGCSNIAYPKLVMELMPSGLRGLMIAVMMAALMSSLTSIFNSSSTLFTMDIWRRLRPGASERELLLVGR 398
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 376 VFVVFLVVISILWIPIIQSSNSGQLFDYIQAVTSYLAPPITALFLLAIFCKRVTEPGAFWGLVFGLGVGLLRMILEFSYP 455
Cdd:cd11489   399 LVTVILVGVSVVWIPILQSSNSGQLYIYIQSVTSYLAPPVTAVFVLAVFWRRANEQGAFWGLMAGLVVGLTRMVLEFAHP 478
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 456 APACGEVDRRPAVLKDFHYLYFAILLCGLTAIVIVIVSLCTTPIPEEQLTRLTWWTrncplselekeAHESTPEiserpa 535
Cdd:cd11489   479 APRCGVPDTRPSVLRSMHYLHFAVALCALSGAVVVAGSLLTPPPQSVQIRNLTWWT-----------LAQDTPL------ 541
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 536 gECPAGGGaaenSSLGQEQPEAPSRSWGkllwswfcglSGTPEQALSpaekaaleqkltSIEEEPLWRHVCNINAVLLLA 615
Cdd:cd11489   542 -GIKLGDG----QTLSRRTDGCESVRFA----------SGTPPPIIH------------STTEHPFWARVCGVNAILLMC 594
                         490
                  ....*....|
gi 2217264810 616 INIFLWGYFA 625
Cdd:cd11489   595 VNIFFYAYFA 604
SLC5sbd_SGLT1 cd11486
Na(+)/glucose cotransporter SGLT1;solute binding domain; Human SGLT1 (hSGLT1) is a ...
128-625 0e+00

Na(+)/glucose cotransporter SGLT1;solute binding domain; Human SGLT1 (hSGLT1) is a high-affinity/low-capacity glucose transporter, which can also transport galactose. In the transport mechanism, two Na+ ions first bind to the extracellular side of the transporter and induce a conformational change in the glucose binding site. This results in an increased affinity for glucose. A second conformational change in the transporter follows, bringing the Na+ and glucose binding sites to the inner surface of the membrane. Glucose is then released, followed by the Na+ ions. In the process, hSGLT1 is also able to transport water and urea and may be a major pathway for transport of these across the intestinal brush-border membrane. hSGLT1 is encoded by the SLC5A1 gene and expressed mostly in the intestine, but also in the trachea, kidney, heart, brain, testis, and prostate. The WHO/UNICEF oral rehydration solution (ORS) for the treatment of secretory diarrhea contains salt and glucose. The glucose, along with sodium ions, is transported by hSGLT1 and water is either co-transported along with these or follows by osmosis. Mutations in SGLT1 are associated with intestinal glucose galactose malabsorption (GGM). Up-regulation of intestinal SGLT1 may protect against enteric infections. SGLT1 is expressed in colorectal, head and neck, and prostate tumors. Epidermal growth factor receptor (EGFR) functions in cell survival by stabilizing SGLT1, and thereby maintaining intracellular glucose levels. SGLT1 is predicted to have 14 membrane-spanning regions. This subgroup belongs to the solute carrier 5 (SLC5)transporter family.


Pssm-ID: 271379  Cd Length: 636  Bit Score: 591.91  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 128 LHLHQDLGILLVVTAVYTIAGGLMAVIYTDALQTVIMVGGALVLMFLGFQDVGWYPGLEQRYRQAIP-NVTVPNTT---- 202
Cdd:cd11486   149 LNLYLAIVILLAITALYTITGGLAAVIYTDTLQTIIMVVGSFILMGFAFNEVGGYDAFMEKYMTAIPsVIGTGNSTsqek 228
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 203 CHLPRPDAFHILRDPVSGDIPWPGLIFGLTVLATWCWCTDQVIVQRSLSAKSLSHAKGGSVLGGYLKILPMFFIVMPGMI 282
Cdd:cd11486   229 CYTPRADSFHIFRDPITGDLPWPGLLFGLSILTLWYWCTDQVIVQRCLSAKNMSHVKAGCILCGYLKLLPMFIMVMPGMI 308
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 283 SRALFPDEVGCVDPDVCQRICGARVGCSNIAYPKLVMALMPVGLRGLMIAVIMAALMSSLTSIFNSSSTLFTIDVWQRFR 362
Cdd:cd11486   309 SRILYTDEIACVVPDECKAVCGTEVGCTNIAYPKLVVELMPNGLRGLMLSVMLASLMSSLTSIFNSASTLFTMDIYTKVR 388
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 363 RKSTEQELMVVGRVFVVFLVVISILWIPIIQSSNSGQLFDYIQAVTSYLAPPITALFLLAIFCKRVTEPGAFWGLVFGLG 442
Cdd:cd11486   389 KKASEKELMIAGRLFMLVLIGISIAWVPIVQSAQSGQLFDYIQSITSYLGPPIAAVFLLAIFCKRVNEPGAFWGLCVGLL 468
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 443 VGLLRMILEFSYPAPACGEVDRRPAVLKDFHYLYFAILLCGLTAIVIVIVSLCTTPIPEEQLTRLTWWTRNCPLSELEKE 522
Cdd:cd11486   469 VGLARMITEFAYGTGSCVNPSNCPTIICGVHYLYFAIILFGISCILILSISLMTKPIPDVHLYRLCWSLRNSKEERIDLD 548
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 523 AHESTPEISERpagecpagggAAENSSLGQEQPEAPSRSwgkllWSWFCGLSGTPEQALSPAEKAALEQKLTSIEEEPLW 602
Cdd:cd11486   549 ADDETEDQDSN----------SMIETDEMREEPGCCKKA-----YNWFCGLDQGNAPKLTKEEEAALKMKLTDTSEKPLW 613
                         490       500
                  ....*....|....*....|...
gi 2217264810 603 RHVCNINAVLLLAINIFLWGYFA 625
Cdd:cd11486   614 RNVVNANGIILLTVAVFCHAFFA 636
SLC5sbd_SGLT1-like cd10329
Na(+)/glucose cotransporter SGLT1 and related proteins; solute binding domain; This subfamily ...
136-625 0e+00

Na(+)/glucose cotransporter SGLT1 and related proteins; solute binding domain; This subfamily includes the solute-binding domain of SGLT proteins that cotransport Na+ with various solutes. Its members include: the human glucose (SGLT1, -2, -4, -5 ), chiro-inositol (SGLT5), and myo-inositol (SMIT) cotransporters. It also includes human SGLT3 which has been characterized as a glucose sensor and not a transporter. It belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271363  Cd Length: 538  Bit Score: 557.57  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 136 ILLVVTAVYTIAGGLMAVIYTDALQTVIMVGGALVLMFLGFQDVGwypGLEQRYRQAIPNVTvpnttchlprpdAFHILR 215
Cdd:cd10329   153 VLLVITAIYTIAGGLKAVIYTDTLQAVILIIGSAILMFLAFNEVG---GGWSAYMAAIPSGT------------AFHLFR 217
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 216 DPVSGDIPWPGLIFGLTVLATWCWCTDQVIVQRSLSAKSLSHAKGGSVLGGYLKILPMFFIVMPGMISRALFPDEVGCVD 295
Cdd:cd10329   218 PPDDPDLPWPGLLLGYPILGIWYWCTDQVIVQRVLAAKNLKHARRGALFAGYLKLLPLFLMVLPGMIARALFPDLVACVV 297
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 296 PdvcqriCGARVGCSNIAYPKLVMALMPVGLRGLMIAVIMAALMSSLTSIFNSSSTLFTIDVWQRFRRKSTEQELMVVGR 375
Cdd:cd10329   298 P------CGNGVGCSDIAYPTLVTELLPVGLRGLVLAVLLAALMSSLTSIFNSASTLFTMDIYKRLRPEASEKELVRVGR 371
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 376 VFVVFLVVISILWIPIIQsSNSGQLFDYIQAVTSYLAPPITALFLLAIFCKRVTEPGAFWGLVFGLGVGLLRMILEFSYP 455
Cdd:cd10329   372 IATLVVVVISILWAPIIQ-AQGGSLFNYIQSVLSYLAPPIAAVFLLGIFWKRTNEQGAFWGLIAGLVLGLVRLILEFAYG 450
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 456 APacgevDRRPAVLKDFHYLYFAILLCGLTAIVIVIVSLCTTPIPEEQLTRLTWWTRncplselekeahestpeiserpa 535
Cdd:cd10329   451 EP-----DTRPAIIGGIHFLYFAFLLFVVSVIVTVIVSLLTPPPPAEKLAGLTWSTR----------------------- 502
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 536 gecpagggaaensslgqeqpeapsrswgkllwswfcglsgtpeqalspaekaalEQKLTSIEEEPLWRHVCNINAVLLLA 615
Cdd:cd10329   503 ------------------------------------------------------LTKETSTLERPPWYKNVRILAILLLA 528
                         490
                  ....*....|
gi 2217264810 616 INIFLWGYFA 625
Cdd:cd10329   529 LTIFLYGYFA 538
SLC5sbd_SGLT6 cd11490
Na(+)/chiro-inositol cotransporter SGLT6 and related proteins; solute-binding domain; Human ...
137-625 0e+00

Na(+)/chiro-inositol cotransporter SGLT6 and related proteins; solute-binding domain; Human SGLT6 (also called KST1, SMIT2) is a chiro-inositol transporter, which also transports myo-inositol. It is encoded by the SLC5A11 gene. Xenopus Na1-glucose cotransporter type 1 (SGLT-1)-like protein is predicted to contain 14 membrane-spanning regions. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271381  Cd Length: 602  Bit Score: 555.29  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 137 LLVVTAVYTIAGGLMAVIYTDALQTVIMVGGALVLMFLGFQDVGWYPGLEQRYRQAIPNVTVPNTTCHLPRPDAFHILRD 216
Cdd:cd11490   157 LLGITALYTVAGGLAAVIYTDALQTIIMVIGALILMGYSFAEVGGFEALLEKYFQAIPSIRSPNSTCGIPREDAFHIFRD 236
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 217 PVSGDIPWPGLIFGLTVLATWCWCTDQVIVQRSLSAKSLSHAKGGSVLGGYLKILPMFFIVMPGMISRALFPDEVGCVDP 296
Cdd:cd11490   237 PVTSDLPWPGVLLGMSIPSLWYWCTDQVIVQRSLAAKNLSHAKGGSLLAAYLKVLPLFMMVIPGMISRILFPDQVACADP 316
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 297 DVCQRICGARVGCSNIAYPKLVMALMPVGLRGLMIAVIMAALMSSLTSIFNSSSTLFTIDVWQRFRRKSTEQELMVVGRV 376
Cdd:cd11490   317 EVCKEICGNPSGCSDIAYPKLVMELLPTGLRGLMMAVMLAALMSSLTSIFNSASTIFTMDLWRHIRPRASEWELMIVGRV 396
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 377 FVVFLVVISILWIPIIQSSNSGQLFDYIQAVTSYLAPPITALFLLAIFCKRVTEPGAFWGLVFGLGVGLLRMILEFSYPA 456
Cdd:cd11490   397 FVLVLVVVSILWIPLVQASQGGQLFIYIQSISSYLQPPVAVVFIAGCFWKRTNEKGAFWGLMVGLAVGLTRMVLDFIYVT 476
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 457 PACGEVDRRPAVLKDFHYLYFAILLCGLTAIVIVIVSLCTTPIPEEQLTRLTWWTRNCPlsELEKEAHESTpeiserpag 536
Cdd:cd11490   477 PQCDQPDTRPDIVKYVHYLYFSMILTILTLVVVVCVSLATEPPSKEMISRLTWFTRFDA--VVESEELKKA--------- 545
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 537 ecpagggaaensslgqeqpeapsrswgkLLwsWFCGLSGTPEQALSpaEKAALEQKLTSIEEEPLWRHVCNINAVLLLAI 616
Cdd:cd11490   546 ----------------------------IL--WLCGMEKQTEKSSS--SPAPPEAAMVSLEEEPLMKHVLNANLIICVSV 593

                  ....*....
gi 2217264810 617 NIFLWGYFA 625
Cdd:cd11490   594 AVFLWAYFA 602
SLC5sbd_SGLT2 cd11487
Na(+)/glucose cotransporter SGLT2 and related proteins; solute-binding domain; Human SGLT2 ...
137-625 7.53e-179

Na(+)/glucose cotransporter SGLT2 and related proteins; solute-binding domain; Human SGLT2 (hSGLT2) is a high-capacity, low-affinity glucose transporter, that plays an important role in renal glucose reabsorption. It is encoded by the SLC5A2 gene and expressed almost exclusively in renal proximal tubule cells. Mutations in hSGLT2 cause Familial Renal Glucosuria (FRG), a rare autosomal defect in glucose transport. hSGLT2 is a major drug target for regulating blood glucose levels in diabetes. hSGLT2 is predicted to have 14 membrane-spanning regions. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 212056 [Multi-domain]  Cd Length: 583  Bit Score: 519.48  E-value: 7.53e-179
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 137 LLVVTAVYTIAGGLMAVIYTDALQTVIMVGGALVLMFLGFQDVGWYPGLEQRYRQAIPNVTVP--------NTTCHLPRP 208
Cdd:cd11487   158 LLGITMIYTVTGGLAALMYTDTVQTFVIIGGACVLMGYAFHEVGGYSALFEKYLKAVPSLTVSedpavgniSSSCYRPRP 237
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 209 DAFHILRDPVSGDIPWPGLIFGLTVLATWCWCTDQVIVQRSLSAKSLSHAKGGSVLGGYLKILPMFFIVMPGMISRALFP 288
Cdd:cd11487   238 DSYHLLRDPVTGDLPWPALILGLTIVSSWYWCSDQVIVQRCLAARSLTHVKAGCILCGYLKLLPMFLMVMPGMISRVLYP 317
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 289 DEVGCVDPDVCQRICGARVGCSNIAYPKLVMALMPVGLRGLMIAVIMAALMSSLTSIFNSSSTLFTIDVWQRFRRKSTEQ 368
Cdd:cd11487   318 DEVACVEPSVCLRVCGTEVGCSNIAYPKLVVKLMPNGLRGLMLAVMLAALMSSLASIFNSSSTLFTMDIWTRLRPQAGDK 397
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 369 ELMVVGRVFVVFLVVISILWIPIIQSSNSGQLFDYIQAVTSYLAPPITALFLLAIFCKRVTEPGAFWGLVFGLGVGLLRM 448
Cdd:cd11487   398 ELLLVGRVWVVCIVAVSVAWIPVVQAAQGGQLFDYIQSVSSYLAPPIAAVFFLALFVKRVNEPGAFWGLIGGLLMGLCRM 477
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 449 ILEFSYPAPACGEVDRRPAVLKDFHYLYFAILLCGLTAIVIVIVSLCTTPIPEEQLTRLTWWTRncplselekeaHESTP 528
Cdd:cd11487   478 VPEFSFGSGSCVAPSSCPAIICGVHYLYFAILLFFCSGLLVLIVSLCTPPIPRKHLHRLVFSLR-----------HSKEE 546
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 529 EiserpagecpagggaaensslgqeqpeapsrswgkllwswfcglsgtpeqalspaekaalEQKLTSIEEEPLWRHVCNI 608
Cdd:cd11487   547 R------------------------------------------------------------EDLLPDISEDPKWARVVNL 566
                         490
                  ....*....|....*..
gi 2217264810 609 NAVLLLAINIFLWGYFA 625
Cdd:cd11487   567 NALIMMAVAVFLWGFYA 583
SLC5sbd_SMIT cd11491
Na(+)/myo-inositol cotransporter SMIT and related proteins; solute-binding domain; Human SMIT ...
136-512 9.83e-169

Na(+)/myo-inositol cotransporter SMIT and related proteins; solute-binding domain; Human SMIT is a high-affinity myo-inositol transporter, and is expressed in brain, heart, kidney, and lung. Inhibition of myo-inositol uptake, through down-regulation of SMIT, may be a common mechanism of action of mood stabilizers, including lithium, carbamazepine, and valproate. SMIT is encoded by the SLC5A3 gene, which is a candidate gene for pathogenesis of nervous system dysfunction in Down syndrome (DS). The SNP, 21q22 near SLC5A3-MRPS6-KCNE2, has been associated with coronary heart disease, cardiovascular disease, and myocardial infarction. SMIT may also be involved in the pathogeneisis of congenital cataract. SMIT also plays roles in osteogenesis, bone formation, and bone mineral density determination. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271382  Cd Length: 609  Bit Score: 494.39  E-value: 9.83e-169
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 136 ILLVVTAVYTIAGGLMAVIYTDALQTVIMVGGALVLMFLGFQDVGWYPGLEQRYRQAIPNVT-------VPNTT--CHLP 206
Cdd:cd11491   156 LLLGLTALLTVTGGLAAVIYTDTLQAFLMIIGALTLMIISMMEIGGFEGVKSRYMLASPNVTsilltynLSNTNscCVHP 235
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 207 RPDAFHILRDPVSGDIPWPGLIFGLTVLATWCWCTDQVIVQRSLSAKSLSHAKGGSVLGGYLKILPMFFIVMPGMISRAL 286
Cdd:cd11491   236 KKDAFKLLRDPTDEDVPWPGFILGQTPASIWYWCADQVIVQRVLAAKSLSHAQGATLMAGFIKLLPLFIIVIPGMISRIL 315
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 287 FPDEVGCVDPDVCQRICGARVGCSNIAYPKLVMALMPVGLRGLMIAVIMAALMSSLTSIFNSSSTLFTIDVWQRFRRKST 366
Cdd:cd11491   316 FPDDIACINPEHCMQVCGSRAGCSNIAYPRLVMKIMPSGLRGLMMAVMIAALMSDLTSIFNSASTLFTLDVYKLIRKKAS 395
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 367 EQELMVVGRVFVVFLVVISILWIPIIQSSNSGQLFDYIQAVTSYLAPPITALFLLAIFCKRVTEPGAFWGLVFGLGVGLL 446
Cdd:cd11491   396 SRELMIVGRIFVAVMVVISIAWIPVIQEMQGGQLYLYIQEVAAYLTPPVASLYLLAIFWKRTTEQGAFYGGMAGFVLGAV 475
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2217264810 447 RMILEFSYPAPACGEVDRRPAVLKDFHYLYFAILLCGLTAIVIVIVSLCTTPIPEEQLTRLTWWTR 512
Cdd:cd11491   476 RLILAFAYRAPECGQPDNRPGIIKDIHYMYFATALFWITGLITVIVSLLTPPPTKENIRTTTFWTK 541
YidK COG4146
Uncharacterized membrane permease YidK, sodium:solute symporter family [General function ...
136-447 9.01e-103

Uncharacterized membrane permease YidK, sodium:solute symporter family [General function prediction only];


Pssm-ID: 443317 [Multi-domain]  Cd Length: 444  Bit Score: 319.01  E-value: 9.01e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 136 ILLVVTAVYTIAGGLMAVIYTDALQTVIMVGGALVLMFLGFQDVG---WYPGLEQRYRQAipnvtvpnttchlprPDAFH 212
Cdd:COG4146   161 GLGIIAGIYTIFGGLKAVAYTDVIQGIGLIIGGLLITVLGLDAVGdgsVLAGWSALLKVP---------------PEKFN 225
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 213 ILRDPVSGDIPWPGLIFGLTVLATWCWCTDQVIVQRSLSAKSLSHAKGGSVLGGYLKILPMFFIVMPGMISRALFPDEVg 292
Cdd:COG4146   226 MIGPADDPDLPWLGIFTGMPILNLFYWGTNQYIVQRALGAKNLKEAQKGVLFAGFLKLLIPFIVVLPGIIAFVLFPDGL- 304
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 293 cVDPDvcqricgarvgcsnIAYPKLVMALMPVGLRGLMIAVIMAALMSSLTSIFNSSSTLFTIDVWQRFRRK-STEQELM 371
Cdd:COG4146   305 -DNPD--------------QAYPTLVKNLLPVGLKGLVAAALFAAIMSSLASALNSSSTLFTLDIYKKYFNPnASEKQLV 369
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2217264810 372 VVGRVFVVFLVVISILWIPIIqsSNSGQLFDYIQAVTSYLAPPITALFLLAIFCKRVTEPGAFWGLVFGLGVGLLR 447
Cdd:COG4146   370 KVGRIATVVLAVIAILIAPLI--GNADGLFQYIQEVTGFFSPPILAVFLLGLFWKRVTAKAAKVALIAGIVLSILL 443
sss TIGR00813
transporter, SSS family; The Solute:Sodium Symporter (SSS) Family (TC 2.A.21) Members of the ...
130-440 9.01e-100

transporter, SSS family; The Solute:Sodium Symporter (SSS) Family (TC 2.A.21) Members of the SSS family catalyze solute:Na+ symport. The solutes transported may be sugars, amino acids, nucleosides, inositols, vitamins, urea or anions, depending on the system. Members of the SSS family have been identified in bacteria, archaea and animals, and all functionally well characterized members catalyze solute uptake via Na+ symport. Proteins of the SSS generally share a core of 13 TMSs, but different members of the family may have different numbers of TMSs. A 13 TMS topology with a periplasmic N-terminus and a cytoplasmic C-terminus has been experimentally determined for the proline:Na+ symporter, PutP, of E. coli. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273282 [Multi-domain]  Cd Length: 407  Bit Score: 310.00  E-value: 9.01e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 130 LHQDLGILLVVTAVYTIAGGLMAVIYTDALQTVIMVGGALVLMFLGFQDVGWYPGLEQRYRQAIPNVTvpnttchlPRPD 209
Cdd:TIGR00813 116 LYLSLLLLGAITILYTVFGGLKAVVWTDTIQAVIMILGTFILPVFAFSEVGGLGTFVEKASQAAPTNP--------SPDD 187
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 210 AFHILRDPVSGDIPWPGLIFGLTVLATWCWcTDQVIVQRSLSAKSLSHAKGGSVLGGYLKILPMFFIVMPGMISRALFPD 289
Cdd:TIGR00813 188 LYDFFRDPSTSDLPWGAGVFGLPHVALWYW-TNQVIVQRCLAAKSAKHAKKGCLISGVLKLLPMFGAVLPGLIARALYTD 266
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 290 evgcVDPDvcqrICGARVGCSNIAYPKLVMALMPVGLRGLMIAVIMAALMSSLTSIFNSSSTLFTIDVWQRFRRKSTEQE 369
Cdd:TIGR00813 267 ----IDPA----LAGAVNQNSDQAYPLLVQELMPPGLAGLFLAAILAAVMSTLSSQLNSASTVFTMDLYKKIIRPNASGE 338
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2217264810 370 LMVVGRVFVVFLVVISILWipIIQSSNSGQLFDYIQAVTSYLAPPITALFLLAIFCKRVTEPGAFWGLVFG 440
Cdd:TIGR00813 339 KKIVMRGRIAVLVAAVIAG--FVAAAQGGQVLQYVQEAFGGLGAPFLPVFLLGIFWKRMNAKGALAGMIAG 407
SSF pfam00474
Sodium:solute symporter family; This family includes Swiss:P33413 which is not in the Prosite ...
128-440 1.96e-99

Sodium:solute symporter family; This family includes Swiss:P33413 which is not in the Prosite entry. Membership of this family is supported by a significant blast score.


Pssm-ID: 109527 [Multi-domain]  Cd Length: 406  Bit Score: 309.27  E-value: 1.96e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 128 LHLHQDLGILLVVTAVYTIAGGLMAVIYTDALQTVIMVGGALVLMFLGFQDVGWYPGLEQRYRQAIPNVTvpnttcHLPR 207
Cdd:pfam00474 118 LNYYTAVLLLGALTAIYTFFGGFLAVSWTDTIQAVLMLFGTIILMIIVFHEVGGYSSAVEKYMTADPNGV------DLYT 191
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 208 PDAFHILRDPVSGDIPWPGLIFGLTVLatwcwctdQVIVQRSLSAKslshaKGGSVLGGYLKILPMFFIVMPGMISRALF 287
Cdd:pfam00474 192 PDGLHILRDPLTGLSLWPGLVLGTTGL--------PHILQRCLAAK-----DAKCIRCGVLILTPMFIIVMPGMISRGLF 258
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 288 PDEVGCVDPDVCqricGARVGCSNIAYPKLVMALMPVGLRGLMIAVIMAALMSSLTSIFNSSSTLFTIDVWQRFRRKSTE 367
Cdd:pfam00474 259 AIALAGANPRAC----GTVVGCSNIAYPTLAVKLGPPGLAGIMLAVMLAAIMSTLTSQLLSSSSAFTHDLYKNIRRKASA 334
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2217264810 368 QELMVVGRVFVVFLVVISILWIPIIQSSNSGqLFDYIQAVTSYLAPPITALFLLAIFCKRVTEPGAFWGLVFG 440
Cdd:pfam00474 335 TEKELVGRSRIIVLVVISLAILLAVQPAQMG-IAFLVQLAFAGLGSAFLPVILLAIFWKRVNEQGALWGMIIG 406
SLC5sbd_u2 cd11478
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 ...
128-504 6.10e-63

Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271372  Cd Length: 496  Bit Score: 216.00  E-value: 6.10e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 128 LHLHQDLGILL--VVTAVYTIAGGLMAVIYTDALQTVIMVGGALVLMFLGFQDVGWYPGLEQRYRQAIPNVTVPNTTCHL 205
Cdd:cd11478   144 LGWPLWLSIILsaAIVLAYTTLGGLTSAIYNEVLQFFLIVAGLIPLVIIGLIKVGGWDGLSEKIDANGPPGWNGLSWGPQ 223
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 206 PRPDAFhilrdPVsgdIPWPGLIFGLT-VLATWCWCTDQVIVQRSLSAKSLSHAKGGSVLGGYLKILPMFFIVMPGMISR 284
Cdd:cd11478   224 GSQSTN-----PM---GVNLGLVFGLGfVLSFGYWTTNFLEVQRAMAAKDLSAARRTPLIAAFPKMFIPFLVILPGLIAL 295
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 285 ALFPDEVGCVDPDvcqricgarvgcSNIAYPKLVMALMPVGLRGLMIAVIMAALMSSLTSIFNSSSTLFTIDVWQRFRRK 364
Cdd:cd11478   296 VLVPELGASGGLD------------YNQALPYLMAKYLPPGLLGLGITALLAAFMSGMAGNVSAFNTVFTYDIYQTYIVK 363
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 365 S-TEQELMVVGRVFVVFLVVISILWIPIIQSSNSgqLFDYIQAVTSYLAPPITALFLLAIFCKRVTEPGAFWGLVFGLGV 443
Cdd:cd11478   364 DaPDKHYLKVGRIATVVGVLISIGTAYIASSFNN--IMDYLQLLFSFFNAPLFATFLLGMFWKRATPWGGFWGLLAGTAS 441
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2217264810 444 GLLRMILefsypapacgevdrRPAVLKDFH-----YLYFAILLCGLTAIVIVIVSLCTTPIPEEQL 504
Cdd:cd11478   442 AIVLYGL--------------YELGLIVYHsdmapNFYGAWWAFVVCFVVTVLVSLLTKPKPEKEL 493
PutP COG0591
Na+/proline symporter [Amino acid transport and metabolism];
128-508 1.68e-62

Na+/proline symporter [Amino acid transport and metabolism];


Pssm-ID: 440356 [Multi-domain]  Cd Length: 476  Bit Score: 214.30  E-value: 1.68e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 128 LHLHQDLGILL--VVTAVYTIAGGLMAVIYTDALQTVIMVGGALVLMFLGFQDVGWYPGLEQRyrqaipnvtvpnttchL 205
Cdd:COG0591   146 FGIPYWLGILIgaLIVLLYTVLGGLRAVAWTDVLQGILMLVGLILLLIVALSALGGFGELFAA----------------L 209
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 206 PRPDAFHILrdPVSGDIPWPGlIFGLTVLATWCWCTDQVIVQRSLSAKSLSHAKGGSVLGGYLKILPMFFIVMPGMISRA 285
Cdd:COG0591   210 PAPGLLSLF--PGLGFTGWLA-FLGLFLAIGLGYFGQPHIVQRFLAAKSEKEARKAALIGGLLYLLFYLLAALIGLLARA 286
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 286 LFPDEVGcVDPDVcqricgarvgcsniAYPKLVMALMPVGLRGLMIAVIMAALMSSLTSIFNSSSTLFTIDVWQRFRRKS 365
Cdd:COG0591   287 LFPDLPL-ADPDL--------------ALPLLILELLPPGLAGLLLAAILAAAMSTADSQLLAASSVFTRDIYKPFIKPK 351
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 366 -TEQELMVVGRVFVVFLVVISILWIPIIQSSnsgqLFDYIQAVTSYLAPPITALFLLAIFCKRVTEPGAFWGLVFGLGVG 444
Cdd:COG0591   352 aSDKQLLRVSRLAVLVVGLLALLLALLFPSS----ILDLVLLAWGGLGAALLPPLLLGLFWKRATKAGALAGMIAGLVVV 427
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2217264810 445 LLRMILEFSypapacgevdrrpavLKDFHYLYFAILLCGLTAIVIVIVSLCTTPIPEEQLTRLT 508
Cdd:COG0591   428 LLWKLLGGP---------------LGPFGWLYPILPGLLVSLLVFVVVSLLTKPPSEEVLEEFD 476
SLC5sbd_YidK cd10328
uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; ...
139-491 1.10e-57

uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; Uncharacterized subfamily of the solute binding domain of the solute carrier 5 (SLC5) transporter family (also called the sodium/glucose cotransporter family or solute sodium symporter family) that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily includes the uncharacterized Escherichia coli YidK protein, and belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271362  Cd Length: 472  Bit Score: 201.23  E-value: 1.10e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 139 VVTAVYTIAGGLMAVIYTDALQTVIMVGGALVLMFLGFQDVGwypglEQRYRQAIPNVTVPNttchlprPDAFHILRDPV 218
Cdd:cd10328   164 IIGAIYAIFGGLKAVAVSDTINGVGLLIGGLLIPILGLIALG-----DGSFLAGLDTLLTAH-------PEKLNAIGGAD 231
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 219 SgDIPWPGLIFGLTVLATWCWCTDQVIVQRSLSAKSLSHAKGGSVLGGYLKILPMFFIVMPGMISRALFPDEVGCVDpdv 298
Cdd:cd10328   232 S-PVPFSTLFTGMLLVNLFYWCTNQAIIQRALAAKNLKEGQKGVLLAGFFKLLVPLILVLPGIIAFHLYGDGLENAD--- 307
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 299 cqricgarvgcsnIAYPKLVMALMPVGLRGLMIAVIMAALMSSLTSIFNSSSTLFTIDVWQRFRRK-STEQELMVVGRVF 377
Cdd:cd10328   308 -------------MAYPTLVADVLPKWLSGFFAAVLFGAILSSFNSALNSAATLFSLDIYKPIINKnATDKQLVKVGKIF 374
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 378 VVFLVVISILWIPIIQSSNSGqLFDYIQAVTSYLAPPITALFLLAIFCKRVTEPGAFWGLVFGLgvgLLRMILEFsypap 457
Cdd:cd10328   375 GIVLALISMIIAPFIAYAPEG-LFNYLQQFNGFFSIPILAIVLVGFFTKRVPALAAKIALIFGV---ILYALLQF----- 445
                         330       340       350
                  ....*....|....*....|....*....|....*
gi 2217264810 458 acgevdrrpAVLKDFHYLY-FAILLCGLTAIVIVI 491
Cdd:cd10328   446 ---------VFLVPIHFLHvLAILFVICVAIMLII 471
SLC5sbd cd10322
Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding ...
136-493 1.37e-55

Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; This family represents the solute-binding domain of SLC5 proteins (also called the sodium/glucose cotransporter family or solute sodium symporter family) that co-transport Na+ with sugars, amino acids, inorganic ions or vitamins. Family members include: the human glucose (SGLT1, 2, 4, 5), chiro-inositol (SGLT5), myo-inositol (SMIT), choline (CHT), iodide (NIS), multivitamin (SMVT), and monocarboxylate (SMCT) cotransporters, as well as Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) has 13 transmembrane helices (TMs): TM-1, an inverted topology repeat: TMs1-5 and TMs6-10, and TMs 11-12 (TMs numbered to conform to the solute carrier 6 family Aquifex aeolicus LeuT). One member of this family, human SGLT3, has been characterized as a glucose sensor and not a transporter. Members of this family are important in human physiology and disease.


Pssm-ID: 271357 [Multi-domain]  Cd Length: 454  Bit Score: 195.08  E-value: 1.37e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 136 ILLVVTAVYTIAGGLMAVIYTDALQTVIMVGGALVLMFLGFQDVGwyPGLEQRYRQAIPNvtvpnttchlprpdafhILR 215
Cdd:cd10322   154 IAAVIVILYTVFGGMRAVAWTDVIQGIVMLIGVLVAAIFILSKVG--GGGFSALAAALPA-----------------LLL 214
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 216 DPVSGDIPWPGLIFGLTVLATWCWCTDQVIVQRSLSAKSLSHAKGGSVLGGYLKILPMFFIVMPGMISRALFPDEVGcvd 295
Cdd:cd10322   215 ALGPGGGLGWSTILSLILLTGLGVLALPQVFQRILAAKDEKTARRAFLLAGLLLLLIGFLVALIGLAARALFPDLEN--- 291
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 296 pdvcqricgarvgcSNIAYPKLVMALMPVGLRGLMIAVIMAALMSSLTSIFNSSSTLFTIDVWQRFRRKS-TEQELMVVG 374
Cdd:cd10322   292 --------------PDLALPTLINSLLPPGLAGLVLAGLLAAAMSTADSLLLAASTLFTRDIYKPLINPKaSDKKLLRVS 357
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 375 RVFVVFLVVISILWIPIIQSsnsgqLFDYIQAVTSYLAPPITALFLLAIFCKRVTEPGAFWGLVFGLGVGLLRMILEFSY 454
Cdd:cd10322   358 RIAVVVVGVLALLLALLPPS-----ILLLLSLAAGLLAAALFPPLLGGLFWKRATKAGAIAGIIVGLIVTLVWLLLPLAS 432
                         330       340       350
                  ....*....|....*....|....*....|....*....
gi 2217264810 455 PAPacgevdrrpavlkdFHYLYFAILLCgltAIVIVIVS 493
Cdd:cd10322   433 PLG--------------IDPIIPALLVS---LIVFVVVS 454
SLC5sbd_vSGLT cd10325
Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) and related proteins; solute ...
136-455 1.10e-52

Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) and related proteins; solute binding domain; vSGLT transports D-galactose, D-glucose, and alpha-D-fucose, with a sugar specificity in the order of D-galactose >D-fucose >D-glucose. It transports one Na+ ion for each sugar molecule, and appears to function as a monomer. vSGLT has 13 transmembrane helices (TMs): TM-1, an inverted topology repeat: TMs1-5 and TMs6-10, and TMs 11-12 (TMs numbered to conform to the solute carrier 6 family Aquifex aeolicus LeuT). This subfamily belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271360  Cd Length: 523  Bit Score: 189.05  E-value: 1.10e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 136 ILLVVTAVYTIAGGLMAVIYTDALQTVIMVGGALVLMFLGF----QDVGWYPGLEQRYRQAipnvtvpnttchlprPDAF 211
Cdd:cd10325   155 GLALFAAAYSIYGGLKAVAWTDVIQVVFLVLGGLVTTYIALsllgGGEGVFAGFTLLAAEA---------------PEHF 219
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 212 HILRDPVSG-----DIPWPG-LIFGLTVLATWCWCTDQVIVQRSLSAKSLSHAKGGSVLGGYLKILPMFFIVMPGMISRA 285
Cdd:cd10325   220 HMILDKSNPedaykDLPGIAvLLGGLWVANLSYWGFNQYIIQRALAAKSLSEAQKGIVFAAFLKLLIPFIVVIPGIAAYV 299
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 286 LFPDEVGCVDPDVCQricgarvgcSNIAYPKLvMALMPVGLRGLMIAVIMAALMSSLTSIFNSSSTLFTIDVWQRFR-RK 364
Cdd:cd10325   300 LASNLLLPAATGIEK---------PDQAYPWL-LRNLPTGLKGLVFAALTAAIVSSLASMLNSISTIFTMDIYKKYIpKK 369
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 365 STEQELMVVGRVFVVFLVVISILWIPIIqsSNSGQLFDYIQAVTSYLAPPITALFLLAIFCKRVTEPGAFWGLVFGLGVG 444
Cdd:cd10325   370 ASEKQLVNVGRLAAVIALIIAALIAPPL--LGLDQAFQYIQEYTGFISPGILAIFLLGLFWKRATSAGALVAAILSIVLS 447
                         330
                  ....*....|.
gi 2217264810 445 LLRMILEFSYP 455
Cdd:cd10325   448 ALFKFLLPELP 458
PRK10484 PRK10484
putative transporter; Provisional
124-493 1.64e-51

putative transporter; Provisional


Pssm-ID: 236699 [Multi-domain]  Cd Length: 523  Bit Score: 185.86  E-value: 1.64e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 124 VSHPLHLHQDLGILLVVT------AVYTIAGGLMAVIYTDALQTVIMVGGALVLMFLGFQDVG---WYPGLEQRYRQaip 194
Cdd:PRK10484  149 VSELLGISYGAAIWLLVWligiigAIYAVFGGLKAVAVSDTINGIGLLIGGLLVPVFGLIALGdgsFMQGLEQLTTV--- 225
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 195 nvtvpnttchlpRPDAFHILRDPVSgDIPWPGLIFGLTVLATWCWCTDQVIVQRSLSAKSLSHAKGGSVLGGYLKILPMF 274
Cdd:PRK10484  226 ------------HPEKLNSIGGATD-PVPFPTLFTGLILVNLFYWCTNQSIVQRALGAKNLAEGQKGALLAAFFKLLGPL 292
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 275 FIVMPGMISRALFPDEVGCVDpdvcqricgarvgcsnIAYPKLVMALMPVGLRGLMIAVIMAALMSSLTSIFNSSSTLFT 354
Cdd:PRK10484  293 ILVLPGIIAFHLYGDGLPNAD----------------MAYPTLVNDVLPVPLVGFFAAVLFGAILSTFNGFLNSASTLFS 356
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 355 IDVW-QRFRRKSTEQELMVVGRVFVVFLVVISILWIPIIQSSNSGqLFDYIQAVTSYLAPPITALFLLAIFCKRVTEPGA 433
Cdd:PRK10484  357 LDIYkPIINPNASEKQLVKVGKKFGFVLAIISMIVAPLIANAPQG-LYSYLQQLNGIYNVPILAIIIVGFFTKRVPALAA 435
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2217264810 434 FWGLVFGLGV-GLLRMILEFsypapacgevdrrpavlkDFHYLY-FAILLCgLTAIVIVIVS 493
Cdd:PRK10484  436 KVALGFGIILyIIINFVLKF------------------DIHFLYvLAILFV-INVVVMLIIG 478
SLC5sbd_NIS-like_u2 cd11494
uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative ...
139-493 3.01e-45

uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Proteins belonging to the same subfamily as this uncharacterized subgroup include i) NIS, which transports I-, and other anions including ClO4-, SCN-, and Br-, ii) SMVT, which transports biotin, pantothenic acid and lipoate, and iii) the Na(+)/monocarboxylate cotransporters, SMCT1 and 2. SMCT1 is a high-affinity transporter while SMCT2 is a low-affinity transporter. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271385 [Multi-domain]  Cd Length: 473  Bit Score: 167.39  E-value: 3.01e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 139 VVTAVYTIAGGLMAVIYTDALQTVIMVGGALVLMFLGFQ--DVGWYPGLeqryrqaipNVTVPNTtchlpRPDAFHILRD 216
Cdd:cd11494   156 GITIIYTVLGGIKAVIWTDVIQMVIIWAGLFIAFGLLLKllPVGFVDAL---------LVAGKSG-----RLNALDFSFD 221
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 217 PVSGDIPWPGLIfGLTVLATWCWCTDQVIVQRSLSAKSLSHAKGGSVLGGYLKILPMFFIVMPGMIsraLFPDEVGcVDP 296
Cdd:cd11494   222 LSDTYTFWSGLI-GGFFLYLSYFGTDQSQVQRYLTAKSIKEARKSLLLNGFLKFPMQFFILLIGVL---VFVFYQF-NPF 296
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 297 DVCQRICGARVGCSNIAYPKLVMALMPVGLRGLMIAVIMAALMSSLTSIFNSSSTLFTIDVWQRFRRK-STEQELMVVGR 375
Cdd:cd11494   297 PVSFNPAEDETKDTNYIFLRFVLNYLPPGVIGLLIAAIFAAAMSSIDSALNSLATVTVIDIYRRFFKKdASDEHYLKVSR 376
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 376 VFVVFLVVISIlwIPIIQSSNSGQLFDYIQAVTSYLAPPITALFLLAIFCKRVTEPGAFWGLVFGLGVGLLRMIlefsyp 455
Cdd:cd11494   377 LLTVFWGLLAI--VFALFAGLAGSLIEAVNKLGSLFYGPILGVFLLAFFTKKANGKGVFAGAILGVIVVIVLWL------ 448
                         330       340       350
                  ....*....|....*....|....*....|....*...
gi 2217264810 456 apacgevdrrpavLKDFHYLYFAILLCGLTAIVIVIVS 493
Cdd:cd11494   449 -------------FPDVSWLWWNVIGCVVVIGVALLLS 473
SLC5sbd_u1 cd11477
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 ...
127-506 1.17e-37

Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271371  Cd Length: 493  Bit Score: 146.19  E-value: 1.17e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 127 PLHLHQDLGILLVVTAVYTIAGGLMAVIYTDALQTVIMVGGALVLMFLGFQDVGWYPGLEQRyrqaipnvtvpnttchLP 206
Cdd:cd11477   150 PWDPWLTILILGLITLIYTVIGGLWAVVVTDVVQFVIAMAASIAVAVLALNAVGGPGGLFAQ----------------LP 213
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 207 rpdAFHILRDPVSGDIPWPGLIFGLTVLATWCWC----TDQVIVQRSLSAKSLSHAKGGSVLGG--YLkILPMFFIVmPG 280
Cdd:cd11477   214 ---EGHLDLFGSGLGASGFYITFFFILFFGWYPLsysgGGWYLAQRYLSAKSEKAAKAAAWLFAalYL-VRPWPWML-PA 288
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 281 MISRALFPD-EVGCVDPDvcqricgarvgcsnIAYPKLVMALMPVGLRGLMIAVIMAALMSSLTSIFNSSSTLFTIDVWQ 359
Cdd:cd11477   289 LAALVLYPDlDDPEADFE--------------LAYPMMIKEYLPAGLLGLVLAGLLAATMSTVSTHLNWGAAYLVNDIYK 354
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 360 RF-RRKSTEQELMVVGRVFVVFLVVISILwIPIIQSSNSGqLFDYIQAVTSYLAPPITALFLLAIFCKRVTepgaFWGLV 438
Cdd:cd11477   355 RFiKPNASEKHLLKVGRLATVLFGLLSIV-VALASDSIGG-AFWIVLALGAGLGGPLILPWLWWRFNAWTE----IWAMI 428
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2217264810 439 FGLGVGLLrmileFSYPAPACGEvdrrpavlkDFHYLYFAILLCGLTAIVIVIVSLCTTPIPEEQLTR 506
Cdd:cd11477   429 ASIIVGLV-----VSVLLKVFGL---------PEDFLFSFLVPVLLSLVVWLAVTLLTPPTDEETLVA 482
SLC5sbd_NIS-like_u3 cd11495
uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative ...
139-495 8.72e-37

uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Proteins belonging to the same subfamily as this uncharacterized subgroup include i) NIS, which transports I-, and other anions including ClO4-, SCN-, and Br-, ii) SMVT, which transports biotin, pantothenic acid and lipoate, and iii) the Na(+)/monocarboxylate cotransporters SMCT1 and 2. SMCT1 is a high-affinity transporter while SMCT2 is a low-affinity transporter. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271386 [Multi-domain]  Cd Length: 473  Bit Score: 143.45  E-value: 8.72e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 139 VVTAVYTIAGGLMAVIYTDALQTVIMVGGALVLMFLGFQDVGWypGLEQRYRQAIPNvtvpnttchlprpDAFHILRDPV 218
Cdd:cd11495   159 VLCIIYTVLGGIEAVIWTDVIQGVVLLGGALLCLIILLFSIPG--GFGEVFDIAIAN-------------GKFSLGDFSF 223
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 219 SGDIPW-PGLIFGLTVLATWCWCTDQVIVQRSLSAKSLSHAKGGSVLGGYLKI------------LPMFFIVMPGMISRA 285
Cdd:cd11495   224 SLTESTiWVIFIGGIFNNLQSYTSDQDVVQRYLTTKSIKEAKKSLWTNALLALpvallffgigtaLYVFYQQHPELLPAG 303
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 286 LFPDEVgcvdpdvcqricgarvgcsniaYPKLVMALMPVGLRGLMIAVIMAALMSSLTSIFNSSSTLFTIDVWQRFRRKS 365
Cdd:cd11495   304 INGDAV----------------------FPYFIVTQLPVGVAGLIIAAIFAAAMSTISSSLNSVATCITTDFYKRLSPDP 361
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 366 TEQELMVVGRVFVVFLVVISILWIPIIQSSNSGQLFDYIQAVTSYLAPPITALFLLAIFCKRVTEPGAFWGLVFGLGVGL 445
Cdd:cd11495   362 SDKQYLKVARLITLLVGLLGTLVALYLANAGVKSLLDAFNTLTGLFGGGLAGLFLLGIFTKRANAKGALVGIIVSIIVIF 441
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2217264810 446 LrmiLEFSYPapacgevdrrpavlkDFHYLYFAIllCGLTAIVIV--IVSLC 495
Cdd:cd11495   442 W---ISLLYT---------------PIHFFLYSV--IGTLVCFVVgyVVSLL 473
SLC5sbd_NIS-like cd10326
Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute ...
136-493 4.30e-31

Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute binding domain; NIS (product of the SLC5A5 gene) transports I-, and other anions including ClO4-, SCN-, and Br-. SMVT (product of the SLC5A6 gene) transports biotin, pantothenic acid and lipoate. This subfamily also includes SMCT1 and 2. SMCT1(the product of the SLC5A8 gene) is a high-affinity transporter of various monocarboxylates including lactate and pyruvate, short-chain fatty acids, ketone bodies, nicotinate and its structural analogs, pyroglutamate, benzoate and its derivatives, and iodide. SMCT2 (product of the SLC5A12 gene) is a low-affinity transporter for short-chain fatty acids, lactate, pyruvate, and nicotinate. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271361 [Multi-domain]  Cd Length: 472  Bit Score: 126.91  E-value: 4.30e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 136 ILLVVTAVYTIAGGLMAVIYTDALQTVIMVGGALVLMFLGFQDVGWypgleqryrqAIPNVTVPNTTCHLPRPDAFHILR 215
Cdd:cd10326   156 ITGLLIWLYTFRGGIKTVVWTDTLQTVFLLVGLVLTIIIISNSLGL----------GFGEAISAAGESGYSRIFNFDDDN 225
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 216 DPVSgdipwpgliFGLTVLATWCWC-----TDQVIVQRSLSAKSLSHAKGGSVLGGYLKILPMFFIVMPG--MISRAlfp 288
Cdd:cd10326   226 SRRT---------FWKQFLGGIFITiamtgLDQDMMQRNLSCKNLKDAQKNMLTFGVILVPVNLLFLLLGvlLYTYA--- 293
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 289 devgcvdpdvcqRICGARV--GCSNIAYPKLVMALMPVGLRGLMIAVIMAALMSSLTSIFNSSSTLFTIDVWQRFRRKS- 365
Cdd:cd10326   294 ------------QKNGIALpaKDSDQLFPYFALNGLPPGVSGLFVAGIIAAAMSSADSALTALTTSFCVDILNRFKRKSe 361
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 366 --TEQELMVVGRVFVVFLVVISILWIpiiqsSNSGQLFDYIQAVTSYLAPPITALFLLAIFCKRVTEPGafWGLVFGLGV 443
Cdd:cd10326   362 kkSERKYVHIAFSLTFVLGILVFGSA-----SNSGSLIDAIFKVAGYTYGPLLGLFAFGLFTKRAVKDK--WVPLVGLLA 434
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|
gi 2217264810 444 GLLRMILefsypapacgevDRRPAVLKDFHYLYFAILLCGLTAIVIVIVS 493
Cdd:cd10326   435 PVLSYLL------------VSNSEGFFGYKFGFELLIINGLLTFLGLLLS 472
SLC5sbd_NIS-like_u1 cd11493
uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative ...
136-457 1.89e-30

uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Proteins belonging to the same subfamily as this uncharacterized subgroup include i) NIS, which transports I-, and other anions including ClO4-, SCN-, and Br-, ii) SMVT, which transports biotin, pantothenic acid and lipoate, and iii) the Na(+)/monocarboxylate cotransporters SMCT1 and 2. SMCT1 is a high-affinity transporter while SMCT2 is a low-affinity transporter. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271384 [Multi-domain]  Cd Length: 479  Bit Score: 125.02  E-value: 1.89e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 136 ILLVVTAVYTIAGGLMAVIYTDALQTVIMVGGAL-VLMFLGFQDVGWYPGLEQryrqaipnvtvpnttcHLPRPDAFHIL 214
Cdd:cd11493   157 IISVVTLLYTYFGGIRAVVWTDVIQLVVYIGGAVaALAYLLGALPADWLQIAA----------------AAGKFHLFDLS 220
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 215 RDPVSGDIP---WPGLIfGLTVLATWCWCTDQVIVQRSLSAKSLSHAKGgSVLGGYLKILPMFFIVMpgMISRALFPDEV 291
Cdd:cd11493   221 DLILGLTSPytfWAAII-GGALLSMASHGTDQLMVQRLLACRNLRDAQK-ALIGSGVVVFPQFALFL--LIGLLLYVYYG 296
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 292 GCVDPdvcqricGARVGCSNIAYPKLVMALMPVGLRGLMIAVIMAALMSSLTSIFNSSSTLFTIDVWQRFRRKS-TEQEL 370
Cdd:cd11493   297 GASLA-------ALGLGSPDEVFPYFIVHELPAGLRGLLIAGILAAAMSTLSSALNSLASSTVQDLYQPWKRRRlSDEKL 369
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 371 MVVGRVFVVFLVVISILwIPIIQSSNSGQLFDYIQAVTSYLAPPITALFLLAIFCKRVTEPGAFWGLVFGLGVGLLRMIL 450
Cdd:cd11493   370 LRASRLLTLVWAVVLVG-IALLFQYTDQPVVELGLSIASFTYGGLLGVFLLGLLTRRASQRDAIAAFIVGFLVMLLLIFG 448

                  ....*..
gi 2217264810 451 EFSYPAP 457
Cdd:cd11493   449 VKFLGLL 455
SLC5sbd_PutP cd11475
Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Escherichia coli ...
134-446 1.08e-27

Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Escherichia coli PutP catalyzes the Na+-coupled uptake of proline with a stoichiometry of 1:1. The putP gene is part of the put operon; this operon in addition encodes a proline dehydrogenase, allowing the use of proline as a source of nitrogen and/or carbon. This subfamily also includes the Bacillus subtilis Na+/proline cotransporter (OpuE) which has an osmoprotective instead of catabolic role. Expression of the opuE gene is under osmotic control and different sigma factors contribute to its regulation; it is also a putative CcpA-activated gene. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271369  Cd Length: 464  Bit Score: 116.45  E-value: 1.08e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 134 LGILL--VVTAVYTIAGGLMAVIYTDALQTVIMVGGALVLMFLGFQDVGWYPGLEQRYRQAIPNvtvpnttchlprpdaf 211
Cdd:cd11475   154 TGLLIgaVVVVAYTFLGGFLAVSWTDFFQGLLMLLALVLVPIVALAALGGLSGLVAALAAIDPG---------------- 217
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 212 hiLRDPVSGDipwPGLIFGLTVLATWCWCTDQV----IVQRSLSAKSLSHAKGGSVLGGYLKILPMFFIVMPGMISRALF 287
Cdd:cd11475   218 --LLSPFGGD---LGAGGLLAIISLLAWGLGYFgqphILVRFMAIRSPKEIKKARRIAMVWMILFLLGAVLVGLLGRALF 292
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 288 PDEvGCVDPDVcqricgarvgcsniAYPKLVMALMPVGLRGLMIAVIMAALMSSLTSIFNSSSTLFTIDVWQRF-RRKST 366
Cdd:cd11475   293 PDG-LLGDPET--------------VFPVLAQELFPPWLAGILLAAILAAIMSTADSQLLVCSSALTEDLYKAFlRKEAS 357
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 367 EQELMVVGRVFVVFLVVISiLWIPIIQSSNSGQLFDYIQAV-TSYLAPPItalfLLAIFCKRVTEPGAFWGLVFGLGVGL 445
Cdd:cd11475   358 DKELVWVSRLAVLVIALIA-LLIALNPPSSVFSLVSFAWAGlGAAFGPLL----LLSLYWKRTTRQGALAGMIAGAVTVV 432

                  .
gi 2217264810 446 L 446
Cdd:cd11475   433 V 433
SLC5sbd_DUR3 cd11476
Na(+)/urea-polyamine cotransporter DUR3, and related proteins; solute-binding domain; Dur3 is ...
127-494 8.56e-25

Na(+)/urea-polyamine cotransporter DUR3, and related proteins; solute-binding domain; Dur3 is the yeast plasma membrane urea transporter. Saccharomyces cerevisiae DUR3 also transports polyamine. The polyamine uptake of S. cerevisiae DUR3 is activated upon its phosphorylation by polyamine transport protein kinase 2 (PTK2). S. cerevisiae DUR3 also appears to play a role in regulating the cellular boron concentration. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271370  Cd Length: 493  Bit Score: 108.06  E-value: 8.56e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 127 PLHLHQDLGILLVVTAVYTIAGGLMAVIYTDALQTVIMVGGALVLMFLGFQ--DVGWYPGLEQRYRQAIPnvtvpnttcH 204
Cdd:cd11476   151 GMPIVAASFLIPLGVLLYTLFGGLRATFLTDYIHTVIILIILLVFAFAVYTssDIGSPSKVYDLLQEAAP---------D 221
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 205 LPRPDAFHILRDPVSgdipWPGLIFGLT----VLAT-WCwctDQVIVQRSLSAKSLSHAKGGSVLGGYLKILPMFFIVMP 279
Cdd:cd11476   222 LPVEGNQGSYLTFKS----KAGLIFGIInivgNFGTvFL---DQGYWQRAIAARPSAAVKGYFLGGLAWFAIPFLLATTL 294
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 280 GMISRAL----FPDEVGcvdpdvcqricgarvgcSNIAYPKLVMALMPVGLRGLMIAVIMAALMSSLTSIFNSSSTLFTI 355
Cdd:cd11476   295 GLAALALglnpTFEEVS-----------------AGLVLPYVAAALLGKGGAAAVLVLLFMAVTSTASAELIAVSSIVTY 357
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 356 DVWQR-FRRKSTEQELMVVGRVFVVFL-VVISILWIPIIQSSNS-GQLFDYIQAVTSYLAPPItalfLLAIFCKRVTEPG 432
Cdd:cd11476   358 DIYRTyINPNATGKQLLRVSRIAVIGFgLFMGGLAVGLNYIGISlGWLLLFMGILIGSAVFPV----ALGLYWRRQTGTA 433
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2217264810 433 AFWGLVFGLGVGLlrmILEFSYPAPACGEVDRrpAVLKDFHYLYFAILLCGLT-AIVIVIVSL 494
Cdd:cd11476   434 AVVSPIAGLVAGL---AVWLVTAKSYYGEVNV--DTTGGNYPMLAGNLVALFSpAIVSVLLSL 491
SLC5sbd_CHT cd11474
Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding ...
128-455 1.76e-24

Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding domain; Na+/choline co-transport by CHT is Cl- dependent. Human CHT (also called CHT1) is encoded by the SLC5A7 gene, and is expressed in the central nervous system. hCHT1-mediated choline uptake may be the rate-limiting step in acetylcholine synthesis, and essential for cholinergic transmission. Changes in this choline uptake in cortical neurons may contribute to Alzheimer's dementia. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271368 [Multi-domain]  Cd Length: 464  Bit Score: 106.84  E-value: 1.76e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 128 LHLHQDLGILL--VVTAVYTIAGGLMAVIYTDALQTVIMVGGALVLMFLGFQDVGWYPGLEQR----YRQAIPNVTVPNt 201
Cdd:cd11474   142 LGLPVETGILIsaAIVLAYTLFGGMWSVAYTDVVQLIVIFVGLLVLVPFVLTNPGGVDIASAAaagkLRFFPWLGTKSD- 220
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 202 tcHLPRPDAFHILrdpVSGDIPWpglifgltvlatwcwctdQVIVQRSLSAKSLSHAKGGSVLGG--YL--KILPMFFiv 277
Cdd:cd11474   221 --WLIWIDAWLTL---GLGSIPQ------------------QDVFQRVLSAKSEKTAQRLSLLAGvgYLlfAIPPLLI-- 275
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 278 mpGMISRALFPDEVGCVDPDVCQRIcgarvgcsniaYPKLVMALMPVGLRGLMIAVIMAALMSSLTSIFNSSSTLFTIDV 357
Cdd:cd11474   276 --GLAAASIDPSLTQYGLEEDAQLI-----------LPLLLQYLTPLWVQVLFLGALLSAVMSTADSALLAPSSVFSENI 342
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 358 WQ-RFRRKSTEQELMVVGRVFVVFLVVISILwipIIQSSNS-GQLFDYIQAVTSYLA-PPitalFLLAIFCKRVTEPGAF 434
Cdd:cd11474   343 YKpPFRPKASDRELLWVMRISVVVFGAIATL---MALTVESiYGLVELASDLVLVGLfVP----LLAGLYWKRANTYGAL 415
                         330       340
                  ....*....|....*....|.
gi 2217264810 435 WGLVFGLgvgLLRMILEFSYP 455
Cdd:cd11474   416 AAIIVGL---VLRLLGGELLL 433
SLC5sbd_NIS-SMVT cd11492
Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute ...
128-445 2.51e-24

Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute binding domain; NIS (encoded by the SLC5A5 gene) transports I-, and other anions including ClO4-, SCN-, and Br-. SMVT (encoded by the SLC5A6 gene) transports biotin, pantothenic acid and lipoate. This subfamily also includes SMCT1 and -2. SMCT1(encoded by the SLC5A8 gene) is a high-affinity transporter of various monocarboxylates including lactate and pyruvate, short-chain fatty acids, ketone bodies, nicotinate and its structural analogs, pyroglutamate, benzoate and its derivatives, and iodide. SMCT2 (encoded by the SLC5A12 gene) is a low-affinity transporter for short-chain fatty acids, lactate, pyruvate, and nicotinate. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271383 [Multi-domain]  Cd Length: 522  Bit Score: 107.19  E-value: 2.51e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 128 LHLHQDLGILLVVTAVYTIAGGLMAVIYTDALQTVIMVGGALVLMFLGFQDVGwypGLEQRYRQAI-----------PNV 196
Cdd:cd11492   148 INLHIIILVVGIVCIFYTTLGGLKAVVWTDVFQVVVMFGGVLAVIILGTIDVG---GFSEVWEIAEeggrleffnfdPDP 224
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 197 TVPNTTchlprpdafhilrdpvsgdipWpGLIFGLTVlaTWC--WCTDQVIVQRSLSAKSLSHAKGGSVLGGYLKILPMF 274
Cdd:cd11492   225 TVRHTF---------------------W-SLVIGGTF--TWLslYGVNQTQVQRYLSLPSLKSAKKALWLNIVGLILILS 280
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 275 FIVMPGMISRALFPDevgCvDPDVCQRIcgarvGCSNIAYPKLVMALMPV--GLRGLMIAVIMAALMSSLTSIFNSSSTL 352
Cdd:cd11492   281 LCCFTGLVIYAKYHD---C-DPLTAGLI-----KKPDQLLPYFVMDVLGHlpGLPGLFVAGIFSAALSTLSSGLNSLAAV 351
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 353 FTIDVWQRFRRK--STEQELMVVgRVFVVFLVVISILWIPIIQssNSGQLFDYIQAVTSYLAPPITALFLLAIFCKRVTE 430
Cdd:cd11492   352 ILEDFIKPFFKKklSERQATNIM-KLLVVVFGLLCIGLAFLVE--KLGGVLQLSLSIFGITGGPLLGIFTLGMFFPWANS 428
                         330
                  ....*....|....*
gi 2217264810 431 PGAFWGLVFGLGVGL 445
Cdd:cd11492   429 KGALVGLLVGLIFML 443
PanF COG4145
Na+/panthothenate symporter [Coenzyme transport and metabolism];
134-508 1.22e-23

Na+/panthothenate symporter [Coenzyme transport and metabolism];


Pssm-ID: 443316  Cd Length: 484  Bit Score: 104.54  E-value: 1.22e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 134 LGILLVVTAVYTIAGGLMAVIYTDALQTVIMVGGALVLMFLGFQDVGWYPGLEQRYRQAIPN-VTVPNTTCHLPRPdafh 212
Cdd:COG4145   163 LLIFGVTVVLYTTIGGFRAVVLTDAIQGIIMLVGTVLLLIGVISAGGGIENIMSTLAAIDPNlVSPTGPDGFLPRP---- 238
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 213 ilrdpvsgdipwpgLIFGLTVLatWC---WCTDQVIVqRSLSAKSLSHAKGGSVLGGYLKILPMFFIVMPGMISRALFPD 289
Cdd:COG4145   239 --------------FVISFWIL--VGfgvIGLPHTAV-RCMAYKDSKSLHRAMIIGTIVVGLLMFGMHLIGVLGRAVLPD 301
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 290 -EVgcvdPDvcQRIcgarvgcsniayPKLVMALMPVGLRGLMIAVIMAALMSSLTSIFNSSSTLFTIDVWQRFRRKST-- 366
Cdd:COG4145   302 lTV----PD--QVI------------PTLMVKVLPPFLAGIFLAGPLAAIMSTVDSLLLQASSTIVKDLYLNYINPKAse 363
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 367 -EQELMVVGRVFVVFLVVISIL--WIP--IIQSSNsgqLFdyiqAVTSYLA---PPItalfLLAIFCKRVTEPGAFWGLV 438
Cdd:COG4145   364 nEKKLKRLSKLVTLVLGLIVFLlaLNPpdLIIWLN---LF----AFGGLEAaffWPL----VLGLYWKRANATGAIASML 432
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 439 FGLGVGLLRMILefsYPAPAcgevdrrpavlkDFHYLYFAILlcgLTAIVIVIVSLCTTPIPEEQLTRLT 508
Cdd:COG4145   433 VGVASYFLLYYG---NPKIF------------GFHAIVPSLL---ISLIAFLIGSLLGKPPDEERLELFF 484
SLC5sbd_u3 cd11479
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 ...
134-500 6.60e-21

Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271373  Cd Length: 454  Bit Score: 95.75  E-value: 6.60e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 134 LGILL--VVTAVYTIAGGLMAVIYTDALQTVIM-VGGALVLMFLGFQDVGWYPGLEQRyrqaipnvtvpnttchLPrPDA 210
Cdd:cd11479   149 LSILVggGIVVLYSVLGGMWSITLTDIIQFVIKtIGIFLLLLPLALSKAGGLSGLQEK----------------LP-ASY 211
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 211 FHIlrdpvsGDIPWpGLIFGLTVLATWCWCTDQVIVQRSLSAKSLSHAKGGSVLGGYLKILPMFFIVMPGMISRALFPDe 290
Cdd:cd11479   212 FDL------TSIGW-DTIVTYFLLYFFGILIGQDIWQRVFTARSEKVARWGGVAAGLYCVLYGVAGALIGMAAAVLLPD- 283
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 291 vgcvdpdvcqricgarVGCSNIAYPKLVMALMPVGLRGLMIAVIMAALMSSLTSIFNSSSTLFTIDVWQRFRRKSTEQEL 370
Cdd:cd11479   284 ----------------LANPQNAFATMAQEVLPVGLRGLVLAAALAAMMSTASGALLASSTVLTNDVLPRLRRKNESERS 347
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 371 MVVG-RVFVVFLVVISILWIPIIQssnsgqlfDYIQAVTSYLAPPITALF---LLAIFCKRVTEPGAFWGLVFGLGVGLL 446
Cdd:cd11479   348 EVRLsRLFTLLLGVVVIVIAVLVN--------DVVAALTIAYAILVGGLLvpiLGGLFWKRATGAGALASMVAGSVVVLA 419
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2217264810 447 RMILEfsypapacGEVDRRPavlkdfhyLYFAiLLCGLtaIVIVIVSLCTTPIP 500
Cdd:cd11479   420 GMAVD--------GLLANTP--------IYYG-LAVSL--VAFVAVSLLTRPTP 454
SLC5sbd_u4 cd11480
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 ...
136-494 2.94e-14

Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271374  Cd Length: 488  Bit Score: 75.62  E-value: 2.94e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 136 ILLVVTAVYTIAGGLMAVIYTDALQTVIMVGGALVLMFLGFQDVGWYPGLEQRYRQAIPNVTVPNTTCHLPRPdaFHILR 215
Cdd:cd11480   152 VVGALMIVYVVLGGMRATTWVQIIQYVLLLGAFLVPAILVLARFGGNPLGAGPGLLGLAAAAASGAGEAYLAP--GLLLT 229
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 216 DPVSgdipWPGLIFGLtVLATWCwcTDQVIVqRSLSAKSLSHAKGgSVLGGyLKILPMFFIVMP--GMISRALFPDEVgc 293
Cdd:cd11480   230 DPLD----VISLTLAL-MLGTAG--LPHVLM-RFYTVPDARAARK-SVVWA-LGFIGLFYLLAPalGFGARALVGPDV-- 297
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 294 vdpdVCQRICGARVGCSNIAYPKLVMAL-MPVGLRGLMIAVIMAALMSSLTSIFNSSSTLFTIDVWQR-FRRKSTEQELM 371
Cdd:cd11480   298 ----IGAPIAGELDGGGDMAVLLLPEIAgLGDLLLALVAAGAFAAILATVAGLLLAAASALAHDLYAGvIRPGASERREV 373
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 372 VVGRVFVVFLVVISILWIPIIQSSNSGQLfdyiqaVTsyLAPPITA-----LFLLAIFCKRVTEPGAFWGLVFGLGVGLL 446
Cdd:cd11480   374 RVARIAAVVVGVIAILLALLFPPQNVAFL------VA--LAFAIAAsaffpVLVLGIFWRRFTTRGAIAGMLVGLLVSLV 445
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*...
gi 2217264810 447 RMILEFSYPAPACGevdrrpAVLKDFHYLYFAILLCGLTAIVIVIVSL 494
Cdd:cd11480   446 LIVLSPAVSGAPPG------HDFAGFPLTNPGLVSVPLGFLVAIVVSL 487
SLC5sbd_SMVT cd11504
Na(+)/multivitamin cotransporter SMVT and related proteins; solute-binding domain; This ...
139-527 6.72e-14

Na(+)/multivitamin cotransporter SMVT and related proteins; solute-binding domain; This multivitamin transporter SMVT (product of the SLC5A6 gene) transports biotin, pantothenic acid and lipoate, and is essential for mediating biotin uptake into mammalian cells. SMVT is expressed in the placenta, intestine, heart, brain, lung, liver, kidney and pancreas. Biotin may regulate its own cellular uptake through participation in holocarboxylase synthetase-dependent chromatin remodeling events at SMVT promoter loci. The cis regulatory elements, Kruppel-like factor 4 and activator protein-2, regulate the activity of the human SMVT promoter in the intestine. Glycosylation of the hSMVT is important for its transport function. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271394 [Multi-domain]  Cd Length: 527  Bit Score: 74.53  E-value: 6.72e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 139 VVTAVYTIAGGLMAVIYTDALQTVIMVGGALVLMFLGFQDVGwypGLEQRYRQAIPNvtvpnttchlPRPDAFHILRDPV 218
Cdd:cd11504   162 VVCTFYTALGGLKAVIWTDVFQTVVMFAGQLAVIIVGSIEAG---GIARVWRVAAES----------DRIDGFNLSPDPT 228
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 219 SGDIPWPgLIFGLTVLATWCWCTDQVIVQRSLSAKSLSHAKGGSVLGGYLKILPMFFIVMPGMISRALFPDevgcvDPDV 298
Cdd:cd11504   229 IRHTFWT-LVVGGVFNMLALYGVNQAQVQRYLSSRTEKQAKRSCYLVFPGQQLSLCIGCLCGLVMFARYHE-----CDPL 302
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 299 CQRIcgarVGCSNIAYPKLVMALMPV--GLRGLMIAVIMAALMSSLTSIFNSSSTLFTIDVWQRFRRKSTEQELMVVGRV 376
Cdd:cd11504   303 KNGI----VARSDQLVPYFVMDVLDGlpGLPGLFIACLFSGALSTISSAFNSLATVTMEDLIVPKFPDMTEERATLLSKG 378
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 377 FVVFLVVISILWIPIiqSSNSGQLFDYIQAVTSYLAPPITALFLLAIFCKRVTEPGAFWGLVFGLGVGLLRMILEFSYPA 456
Cdd:cd11504   379 LAVGYGLLCLLMAYL--ASTMGQVLQAANSIFGMIGGPLLGLFCLGMFFPCANSAGAVVGLLAGLFMAFWIGIGSKVFPP 456
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2217264810 457 PACGevdrRPAVLKDfhylyfaillCGLTAIVIVIVSLCTTPIPEEQLTRLTWWTRNCPLSELEKEAHEST 527
Cdd:cd11504   457 YSPT----KSTPIND----------CIFPNVTMANATTPTTPFATPTDEPPPGLAELYSLSYMWYSAHNST 513
SLC5sbd_PanF cd10327
Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute ...
134-500 2.99e-13

Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; PanF catalyzes the Na+-coupled uptake of extracellular pantothenate for coenzyme A biosynthesis in cells. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 212037  Cd Length: 472  Bit Score: 72.24  E-value: 2.99e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 134 LGILLVVTAVYTIAGGLMAVIYTDALQTVIMVGGALVLMFLGFQDVGWYPGLEQRYRQAIPNvtvpnttchlprpdafhI 213
Cdd:cd10327   160 LLIFGLTVILYTTIGGFRAVALTDAIQGIVMIIGTVLLLVGVLAAGGGMEAIMATLAEIDPN-----------------L 222
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 214 LRDPVSGDIPWPGLI-----FGLTVLATwcwctdQVIVQRSLSAKSLSHAKGGSVLGGYLKILPMFFIVMPGMISRALFP 288
Cdd:cd10327   223 LTPFGPGFLSPPYILsfwvlVGFGVIGL------PQTAVRCMGYKDSKSMHRAMIIGTVVVGFLMLGMHLAGVLGRAVLP 296
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 289 devgcvDPDVcqricgarvgcSNIAYPKLVMALMPVGLRGLMIAVIMAALMSSLTSIFNSSSTLFTIDVWQRFRRKSTE- 367
Cdd:cd10327   297 ------DLEV-----------PDKVIPTLALKVLPPWLAGLFLAGPLAAIMSTVDSQLILASSAIVKDLYLNYKNKEKKt 359
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 368 ----QELMVVGRVFVVFLVVISILWIP--IIQSSNsgqLFDYIQAVTSYLAPpitalFLLAIFCKRVTEPGAFWGLVFGL 441
Cdd:cd10327   360 sekkVKRISLIITIILGLLVFLLAINPpdLIVWLN---LFAFGGLEAAFFWP-----LVLGLYWKRANATGALASMVVGL 431
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2217264810 442 GVGLLRMILEFSYpapacgevdrrpavlKDFHYLYFAILLCGltaIVIVIVSLCTTPIP 500
Cdd:cd10327   432 VSYILITYLKIKI---------------LGLHPIVPSLLLSL---IAFIIVSLATKKPD 472
SLC5sbd_SMCT cd11505
Na(+)/monocarboxylate cotransporters SMCT1 and 2 and related proteins; solute-binding domain; ...
139-496 1.69e-10

Na(+)/monocarboxylate cotransporters SMCT1 and 2 and related proteins; solute-binding domain; SMCT1 is a high-affinity transporter of various monocarboxylates including lactate and pyruvate, short-chain fatty acids, ketone bodies, nicotinate and its structural analogs, pyroglutamate, benzoate and its derivatives, and iodide. Human SMCT1 (hSMCT1, also called AIT) is encoded by the tumor suppressor gene SLC5A8. SMCT1 is expressed in the colon, small intestine, kidney, thyroid gland, retina, and brain. SMCT1 may contribute to the intestinal/colonic and oral absorption of monocarboxylate drugs. It also mediates iodide transport from thyrocyte into the colloid lumen in thyroid gland and, through transporting L-lactate and ketone bodies, helps maintain the energy status and the function of neurons. SMCT2 is a low-affinity transporter for short-chain fatty acids, lactate, pyruvate, and nicotinate. hSMCT2 is encoded by the SLC5A12 gene. SMCT2 is expressed in the kidney, small intestine, skeletal muscle, and retina. In the kidney, SMCT2 may initiate lactate absorption in the early parts of the tubule, SMCT1 in the latter parts of the tubule. In the retina, SMCT1 and SMCT2 may play a differential role in monocarboxylate transport in a cell type-specific manner. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271395  Cd Length: 538  Bit Score: 63.75  E-value: 1.69e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 139 VVTAVYTIAGGLMAVIYTDALQTVIMVGGALVLMFLG-FQDVGWYPGLEQRYRQAipnvtvpnttchlpRPDAFHILRDP 217
Cdd:cd11505   165 VVCTFYCTLGGLKAVVWTDVFQVGIMVAGFLSVIIQAvVHQGGIHNILNDSYNGS--------------RLNFWDFDPNP 230
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 218 VSGDIPWPgLIFGLTVLATWCWCTDQVIVQRSLSAKSLSHAKggsvLGGYLKILPMFFI----VMPGMISRALFPDevgc 293
Cdd:cd11505   231 LRRHTFWT-ITVGGTFTWTGIYGVNQSQVQRYISCKTRFQAK----LSLYFNLLGLWAIlvcaVFSGLAMYSHYKD---- 301
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 294 vdpdvCQRICGARVGCSNIAYPKLVMAL---MPvGLRGLMIAVIMAALMSSLTSIFNSSSTLFTIDVWQRFRRKSTEQEL 370
Cdd:cd11505   302 -----CDPWTAKIVSAPDQLMPYLVLDIladYP-GLPGLFVACAYSGTLSTVSSSINALAAVTVEDLIKPYFRSLSEKLS 375
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 371 MVVGRVFVVFLVVISILWIPIiqSSNSGQLFDYIQAVTSYLAPPITALFLLAIFCKRVTEPGAFWGLVFGLGVGLLRMIL 450
Cdd:cd11505   376 SWISKGLSLLYGAMCIGMAVA--ASLMGGLLQAALSIFGMVGGPLLGLFSLGILFPFVNSKGALGGLLTGFAISLWVGIG 453
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 451 EFSYPAPAC-----------------------------------GEVDRRPAVLKDFH---YLYFAILLCGLTAIVIVIV 492
Cdd:cd11505   454 AQIYPPPPSktlplplstdgcnktnveangppttempfttsvfqIYLSSRPGLADTWYslsYLYFSTVGTLVCILVGVIV 533

                  ....
gi 2217264810 493 SLCT 496
Cdd:cd11505   534 SLIT 537
SLC5sbd_SMCT2 cd11520
Na(+)/monocarboxylate cotransporter SMCT2 and related proteins; solute-binding domain; SMCT2 ...
139-511 6.11e-10

Na(+)/monocarboxylate cotransporter SMCT2 and related proteins; solute-binding domain; SMCT2 is a low-affinity transporter for short-chain fatty acids, lactate, pyruvate, and nicotinate. Human SMCT2 (hSMCT2) is encoded by the SLC5A12 gene. SMCT2 is expressed in the kidney, small intestine, skeletal muscle, and retina. In the kidney, it is expressed in the apical membrane of the proximal convoluted tubule, along the entire length of the tubule (in contrast to the high-affinity monocarboxylate transporter SMCT1, belonging to a different family, which is limited to the S3 segment of the tubule). SMCT2 may initiate lactate absorption in the early parts of the tubule. In the retina, SMCT1 and SMCT2 may play a differential role in monocarboxylate transport in a cell type-specific manner, SMCT2 is expressed exclusively in Muller cells. Nicotine transport by hSMCT2 is inhibited by several non-steroidal anti-inflammatory drugs. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 212089 [Multi-domain]  Cd Length: 529  Bit Score: 62.17  E-value: 6.11e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 139 VVTAVYTIAGGLMAVIYTDALQTVIMVGGALVLMFLGFQDVGwypGLEQRYRQAIPNvtvpnttchlPRPDAFHILRDPV 218
Cdd:cd11520   165 IVCTFYCTLGGLKAVVWTDAFQMVVMVVGFLTVLIQGSIHNG---GFTNVWETAYNG----------SRLNIFDFDVDPL 231
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 219 SGDIPWPglifgLTVLATWCWC----TDQVIVQRSLSAKSLSHAKggsvLGGYLKILPMFFI----VMPGMISRALFPDe 290
Cdd:cd11520   232 RRHTFWT-----ITVGGTFTWLgiygVNQSTIQRCISCKTEKHAK----LALYLNLLGLWIIlvcaVFSGLIMYSHYKD- 301
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 291 vgcvdpdvCQRICGARVGCSNIAYPKLVM---ALMPvGLRGLMIAVIMAALMSSLTSIFNSSSTLFTID-VWQRFRRKST 366
Cdd:cd11520   302 --------CDPWTSGFISAPDQLMPYFVMeifSTMP-GLPGLFVACAFSGTLSTVAASINALATVTFEDfVKSCFPHLSE 372
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 367 EQELMVVGRVFVVFLVVISILwipIIQSSNSGQLFDYIQAVTSYLAPPITALFLLAIFCKRVTEPGAFWGLVFGLGVGLL 446
Cdd:cd11520   373 KLSTWISKGLCILFGVMCTSM---AVAASLMGGVVQAALSIHGMCGGPMLGLFTLGIVFPFVNWKGALGGLLTGITLSFW 449
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2217264810 447 RMILEFSYPAPAcgevdrrpavlKDFHYLYFAILLCGLTAIVIVIVSLCTTPIPEEQLTRLTWWT 511
Cdd:cd11520   450 VGIGAFIYPAPS-----------SKTLPLELSTAGCILANSTATPTPATPILTSDRPLLADTWYS 503
SLC5sbd_SMCT1 cd11519
Na(+)/monocarboxylate cotransporter SMCT1 and related proteins; solute-binding domain; SMCT1 ...
139-496 1.11e-09

Na(+)/monocarboxylate cotransporter SMCT1 and related proteins; solute-binding domain; SMCT1 is a high-affinity transporter of various monocarboxylates including lactate and pyruvate, short-chain fatty acids, ketone bodies, nicotinate and its structural analogs, pyroglutamate, benzoate and its derivatives, and iodide. Human SMCT1 (hSMCT1, also called AIT) is encoded by the tumor suppressor gene SLC5A8. Its expression is under the control of the C/EBP transcription factor. Its tumor-suppressive role is related to uptake of butyrate, propionate, and pyruvate, these latter are inhibitors of histone deacetylases. SMCT1 is expressed in the colon, small intestine, kidney, thyroid gland, retina, and brain. SMCT1 may contribute to the intestinal/colonic and oral absorption of monocarboxylate drugs. SMCT1 also mediates iodide transport from thyrocyte into the colloid lumen in thyroid gland and through transporting l-lactate and ketone bodies helps maintain the energy status and the function of neurons. In the kidney its expression is limited to the S3 segment of the proximal convoluted tubule (in contrast to the low-affinity monocarboxylate transporter SMCT2, belonging to a different family, which is expressed along the entire length of the tubule). In the retina, SMCT1 and SMCT2 may play a differential role in monocarboxylate transport in a cell type-specific manner, SMCT1 is expressed predominantly in retinal neurons and in retinal pigmented epithelial (RPE) cells. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271402  Cd Length: 542  Bit Score: 61.02  E-value: 1.11e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 139 VVTAVYTIAGGLMAVIYTDALQTVIMVGGALVLMFLGFQDVGwypGLEqryrqaipnvTVPNTTCHLPRPDAFHILRDPV 218
Cdd:cd11519   165 VVCTFYCTLGGLKAVIWTDVFQVGIMVAGFVSVIIRAVVLQG---GIG----------TILNDSYYGGRLNFWDFDPNPL 231
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 219 SGDIPWPgLIFGLTVLATWCWCTDQVIVQRSLSAKSLSHAKggsvLGGYLKILPMFFI----VMPGMISRALFPDevgcv 294
Cdd:cd11519   232 QRHTFWT-IVIGGTFTWTSIYGVNQSQVQRYISCKTRFQAK----MSLYVNLVGLWAIlscaVLSGLAMYSIYKD----- 301
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 295 dpdvCQRICGARVGCSNIAYPKLVMALMPV--GLRGLMIAVIMAALMSSLTSIFNSSSTLFTIDVWQRFRRKSTEQELMV 372
Cdd:cd11519   302 ----CDPWTAKDVSAPDQLMPYLVLDILADypGLPGLFVACAYSGTLSTVSSSINALAAVTVEDLIKPYFRSLSERQLSW 377
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 373 VGRVFVVFLVVISILWIPIiqSSNSGQLFDYIQAVTSYLAPPITALFLLAIFCKRVTEPGAFWGLVFGLGVGL------- 445
Cdd:cd11519   378 ISMGMSVFYGALCIGMAGL--ASLMGALLQAALSIFGMVGGPLLGLFALGILFPFANSIGALVGLMSGFAISLwvgigaq 455
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 446 ---------------------------LRMILEFSYPAPACGEVDRRPAVLKDFH---YLYFAILLCGLTAIVIVIVSLC 495
Cdd:cd11519   456 iypplpektlplplslegcnstynetnWTTTPEMPFTSVFTTQPSSRPPLADNWYslsYLYFSTVGTLVTMLVGLLVSLI 535

                  .
gi 2217264810 496 T 496
Cdd:cd11519   536 T 536
PRK15419 PRK15419
sodium/proline symporter PutP;
141-440 2.51e-05

sodium/proline symporter PutP;


Pssm-ID: 185317  Cd Length: 502  Bit Score: 47.32  E-value: 2.51e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 141 TAVYTIAGGLMAVIYTDALQTVIMVGgALVL--MFLGFQDVGWYPGLEQRYRQAIPNVTVpnttchlprpdafhilrdpv 218
Cdd:PRK15419  171 TILYTFIGGFLAVSWTDTVQASLMIF-ALILtpVIVIISVGGFGDSLEVIKQKSIENVDM-------------------- 229
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 219 sgdipWPGLIF-GLTVLATWC--WCTDQVIVQRSLSAKS---LSHAKGGSVLggyLKILPMFFIVMPGMISRALF---PD 289
Cdd:PRK15419  230 -----LKGLNFvAIISLMGWGlgYFGQPHILARFMAADShhsIVHARRISMT---WMILCLAGAVAVGFFGIAYFnehPA 301
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217264810 290 EVGCVDPDvcqricGARVgcsniaYPKLVMALMPVGLRGLMIAVIMAALMSSLTSIFNSSSTLFTIDVWQRFRRKS-TEQ 368
Cdd:PRK15419  302 VAGAVNQN------AERV------FIELAQILFNPWIAGILLSAILAAVMSTLSCQLLVCSSAITEDLYKAFLRKHaSQK 369
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2217264810 369 ELMVVGRVFVVFLVVISIlwipIIQSSNSGQLFDYIQAVTSYLAPPITALFLLAIFCKRVTEPGAFWGLVFG 440
Cdd:PRK15419  370 ELVWVGRVMVLVVALVAI----ALAANPENRVLGLVSYAWAGFGAAFGPVVLFSVMWSRMTRNGALAGMIIG 437
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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