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Conserved domains on  [gi|2217345598|ref|XP_047304711|]
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fibronectin type III domain-containing protein 3B isoform X2 [Homo sapiens]

Protein Classification

fibronectin type III domain-containing protein( domain architecture ID 10047016)

fibronectin type III (FN3) domain-containing protein may be involved in specific interactions with other molecules through its FN3 domain; similar to fibronectin type-III domain-containing protein 3A/3B

Gene Ontology:  GO:0005515
PubMed:  8981327

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
443-773 1.04e-20

Fibronectin type 3 domain [General function prediction only];


:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 97.77  E-value: 1.04e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217345598  443 NLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGPPTrPLVKGPVTSHGFSVKWDPPKDNGGSEilkYLLEItdGNS 522
Cdd:COG3401    198 DIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPT-GLTATADTPGSVTLSWDPVTESDATG---YRVYR--SNS 271

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217345598  523 EANQWEVAYSGSATEYTFTHLKPGT--LYKLRAcCISTGGHSQCSESLPVRTLSIAPGqcrPPRVL--GRPKHKEVHLEW 598
Cdd:COG3401    272 GDGPFTKVATVTTTSYTDTGLTNGTtyYYRVTA-VDAAGNESAPSNVVSVTTDLTPPA---APSGLtaTAVGSSSITLSW 347

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217345598  599 DvPASESGceVSEYSVEMTEPEDVASEVYH--GPELECTVGNLLPGTVYRFRVRALNDGG-YGPYSD-VSEITTAAGPPG 674
Cdd:COG3401    348 T-ASSDAD--VTGYNVYRSTSGGGTYTKIAetVTTTSYTDTGLTPGTTYYYKVTAVDAAGnESAPSEeVSATTASAASGE 424

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217345598  675 QCKAPCISCTPDGCVLVGWESPDSSGADISEYRLEWGEDEESLELiyHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPY 754
Cdd:COG3401    425 SLTASVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVP--FTTTSSTVTATTTDTTTANLSVTTGSLVGGSGA 502

                          330
                   ....*....|....*....
gi 2217345598  755 SELVLCQTPASAPDPVSTL 773
Cdd:COG3401    503 SSVTNSVSVIGASAAAAVG 521
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
635-969 6.98e-17

Fibronectin type 3 domain [General function prediction only];


:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 85.44  E-value: 6.98e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217345598  635 TVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGPPGqckAPC----ISCTPDGcVLVGWESPDSSGADisEYRLEW 710
Cdd:COG3401    195 GGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPS---APTgltaTADTPGS-VTLSWDPVTESDAT--GYRVYR 268

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217345598  711 GEDE-ESLELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQAG-AGPYSELVLCQTPASAPDPVSTlcvleeepLDAYPDSP 788
Cdd:COG3401    269 SNSGdGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGnESAPSNVVSVTTDLTPPAAPSG--------LTATAVGS 340

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217345598  789 SAcLVLNWEEpcNNGSEILAYTI------DLGDTSI-TVGNTTMHVMKDLLPETTYRIRIQAINEIG-AGPFSQFIKAKT 860
Cdd:COG3401    341 SS-ITLSWTA--SSDADVTGYNVyrstsgGGTYTKIaETVTTTSYTDTGLTPGTTYYYKVTAVDAAGnESAPSEEVSATT 417

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217345598  861 RPLPPLPPRLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKRFISIYRGPSHTYKVQRLTEFTCYSFRIQAAS 940
Cdd:COG3401    418 ASAASGESLTASVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTANLSVTTGSLV 497

                          330       340
                   ....*....|....*....|....*....
gi 2217345598  941 eAGEGPFSETYTFSTTKSVPPTIKAPRVT 969
Cdd:COG3401    498 -GGSGASSVTNSVSVIGASAAAAVGGAPD 525
FN3 super family cl27307
Fibronectin type 3 domain [General function prediction only];
253-549 1.03e-13

Fibronectin type 3 domain [General function prediction only];


The actual alignment was detected with superfamily member COG3401:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 75.42  E-value: 1.03e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217345598  253 PATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPPKLAHRSKSSLTLQWKAPIDNGskITNYLLEWDEGKrNSGFR 332
Cdd:COG3401    201 PGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTGLTATADTPGSVTLSWDPVTESD--ATGYRVYRSNSG-DGPFT 277

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217345598  333 QCFFGSQKHCKLTKLCPAMGYTFRLAARNDIGT-SGYSQEVVCYTLGNIPQMPSAPRLVRAGITWVTLQWSKPegcSPEE 411
Cdd:COG3401    278 KVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGNeSAPSNVVSVTTDLTPPAAPSGLTATAVGSSSITLSWTAS---SDAD 354

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217345598  412 VITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEG-KSCPSEVLVCTTSPDRPGPPT---RPLVK 487
Cdd:COG3401    355 VTGYNVYRSTSGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAVDAAGnESAPSEEVSATTASAASGESLtasVDAVP 434

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2217345598  488 GPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYSGSATEYTFTHLKPGTLY 549
Cdd:COG3401    435 LTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTANLSVTTGSL 496
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 186-280 2.67e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 52.50  E-value: 2.67e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217345598  186 EKPQVSNIQARAVVLSWAPPVGLScGPHSGlsfpysYEVALSDKGRDGKYKI-IYSGEELECNLKDLRPATDYHVRVYAM 264
Cdd:cd00063      5 TNLRVTDVTSTSVTLSWTPPEDDG-GPITG------YVVEYREKGSGDWKEVeVTPGSETSYTLTGLKPGTEYEFRVRAV 77

                           90
                   ....*....|....*.
gi 2217345598  265 YNSVKGSCSEPVSFTT 280
Cdd:cd00063     78 NGGGESPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 960-1033 5.19e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 48.65  E-value: 5.19e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2217345598  960 PPTIKAPRVTQLEGNSCEILWETVPSMKGDPVNYILQVLVGRESEYKQVYK--GEEATFQISGLQTNTDYRFRVCA 1033
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVtpGSETSYTLTGLKPGTEYEFRVRA 76
 
Name Accession Description Interval E-value
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
443-773 1.04e-20

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 97.77  E-value: 1.04e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217345598  443 NLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGPPTrPLVKGPVTSHGFSVKWDPPKDNGGSEilkYLLEItdGNS 522
Cdd:COG3401    198 DIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPT-GLTATADTPGSVTLSWDPVTESDATG---YRVYR--SNS 271

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217345598  523 EANQWEVAYSGSATEYTFTHLKPGT--LYKLRAcCISTGGHSQCSESLPVRTLSIAPGqcrPPRVL--GRPKHKEVHLEW 598
Cdd:COG3401    272 GDGPFTKVATVTTTSYTDTGLTNGTtyYYRVTA-VDAAGNESAPSNVVSVTTDLTPPA---APSGLtaTAVGSSSITLSW 347

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217345598  599 DvPASESGceVSEYSVEMTEPEDVASEVYH--GPELECTVGNLLPGTVYRFRVRALNDGG-YGPYSD-VSEITTAAGPPG 674
Cdd:COG3401    348 T-ASSDAD--VTGYNVYRSTSGGGTYTKIAetVTTTSYTDTGLTPGTTYYYKVTAVDAAGnESAPSEeVSATTASAASGE 424

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217345598  675 QCKAPCISCTPDGCVLVGWESPDSSGADISEYRLEWGEDEESLELiyHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPY 754
Cdd:COG3401    425 SLTASVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVP--FTTTSSTVTATTTDTTTANLSVTTGSLVGGSGA 502

                          330
                   ....*....|....*....
gi 2217345598  755 SELVLCQTPASAPDPVSTL 773
Cdd:COG3401    503 SSVTNSVSVIGASAAAAVG 521
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
635-969 6.98e-17

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 85.44  E-value: 6.98e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217345598  635 TVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGPPGqckAPC----ISCTPDGcVLVGWESPDSSGADisEYRLEW 710
Cdd:COG3401    195 GGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPS---APTgltaTADTPGS-VTLSWDPVTESDAT--GYRVYR 268

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217345598  711 GEDE-ESLELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQAG-AGPYSELVLCQTPASAPDPVSTlcvleeepLDAYPDSP 788
Cdd:COG3401    269 SNSGdGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGnESAPSNVVSVTTDLTPPAAPSG--------LTATAVGS 340

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217345598  789 SAcLVLNWEEpcNNGSEILAYTI------DLGDTSI-TVGNTTMHVMKDLLPETTYRIRIQAINEIG-AGPFSQFIKAKT 860
Cdd:COG3401    341 SS-ITLSWTA--SSDADVTGYNVyrstsgGGTYTKIaETVTTTSYTDTGLTPGTTYYYKVTAVDAAGnESAPSEEVSATT 417

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217345598  861 RPLPPLPPRLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKRFISIYRGPSHTYKVQRLTEFTCYSFRIQAAS 940
Cdd:COG3401    418 ASAASGESLTASVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTANLSVTTGSLV 497

                          330       340
                   ....*....|....*....|....*....
gi 2217345598  941 eAGEGPFSETYTFSTTKSVPPTIKAPRVT 969
Cdd:COG3401    498 -GGSGASSVTNSVSVIGASAAAAVGGAPD 525
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 478-572 6.45e-14

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 68.29  E-value: 6.45e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217345598  478 PGPPTRPLVKgPVTSHGFSVKWDPPKDNGGsEILKYLLEITDGNSEANQWEVAYSGSATEYTFTHLKPGTLYKLRACCIS 557
Cdd:cd00063      1 PSPPTNLRVT-DVTSTSVTLSWTPPEDDGG-PITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVN 78

                           90
                   ....*....|....*
gi 2217345598  558 TGGHSQCSESLPVRT 572
Cdd:cd00063     79 GGGESPPSESVTVTT 93
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
253-549 1.03e-13

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 75.42  E-value: 1.03e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217345598  253 PATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPPKLAHRSKSSLTLQWKAPIDNGskITNYLLEWDEGKrNSGFR 332
Cdd:COG3401    201 PGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTGLTATADTPGSVTLSWDPVTESD--ATGYRVYRSNSG-DGPFT 277

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217345598  333 QCFFGSQKHCKLTKLCPAMGYTFRLAARNDIGT-SGYSQEVVCYTLGNIPQMPSAPRLVRAGITWVTLQWSKPegcSPEE 411
Cdd:COG3401    278 KVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGNeSAPSNVVSVTTDLTPPAAPSGLTATAVGSSSITLSWTAS---SDAD 354

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217345598  412 VITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEG-KSCPSEVLVCTTSPDRPGPPT---RPLVK 487
Cdd:COG3401    355 VTGYNVYRSTSGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAVDAAGnESAPSEEVSATTASAASGESLtasVDAVP 434

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2217345598  488 GPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYSGSATEYTFTHLKPGTLY 549
Cdd:COG3401    435 LTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTANLSVTTGSL 496
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 478-562 3.10e-12

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 63.40  E-value: 3.10e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217345598   478 PGPPTRPLVKgPVTSHGFSVKWDPPK-DNGGSEILKYllEITDGNSEANQWEVAYSGSATEYTFTHLKPGTLYKLRACCI 556
Cdd:smart00060    1 PSPPSNLRVT-DVTSTSVTLSWEPPPdDGITGYIVGY--RVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAV 77


                    ....*.
gi 2217345598   557 STGGHS 562
Cdd:smart00060   78 NGAGEG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 384-473 3.34e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 63.67  E-value: 3.34e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217345598  384 PSAPRLVRA---GITWVTLQWSKPEGcSPEEVITYTLEIQEDENDNLFH-PKYTGEDLTCTVKNLKRSTQYKFRLTASNT 459
Cdd:cd00063      1 PSPPTNLRVtdvTSTSVTLSWTPPED-DGGPITGYVVEYREKGSGDWKEvEVTPGSETSYTLTGLKPGTEYEFRVRAVNG 79

                           90
                   ....*....|....
gi 2217345598  460 EGKSCPSEVLVCTT 473
Cdd:cd00063     80 GGESPPSESVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
288-369 6.24e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 59.74  E-value: 6.24e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217345598  288 PFPPKLAHRSKSSLTLQWKAPIDNGSKITNYLLEWDEGKRNSGFRQCF-FGSQKHCKLTKLCPAMGYTFRLAARNDIGTS 366
Cdd:pfam00041    3 PSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGEPWNEITvPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEG 82


                   ...
gi 2217345598  367 GYS 369
Cdd:pfam00041   83 PPS 85
fn3 pfam00041
Fibronectin type III domain;
479-563 1.24e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 58.58  E-value: 1.24e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217345598  479 GPPTRPLVKgPVTSHGFSVKWDPPKDnGGSEILKYLLEITDGNSEANQWEVAYSGSATEYTFTHLKPGTLYKLRACCIST 558
Cdd:pfam00041    1 SAPSNLTVT-DVTSTSLTVSWTPPPD-GNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNG 78


                   ....*
gi 2217345598  559 GGHSQ 563
Cdd:pfam00041   79 GGEGP 83
fn3 pfam00041
Fibronectin type III domain;
792-853 4.14e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 57.42  E-value: 4.14e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217345598  792 LVLNWEEPCNNGSEILAYTIDL-------GDTSITVGNTTMHVM-KDLLPETTYRIRIQAINEIGAGPFS 853
Cdd:pfam00041   16 LTVSWTPPPDGNGPITGYEVEYrpknsgePWNEITVPGTTTSVTlTGLKPGTEYEVRVQAVNGGGEGPPS 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 792-860 3.35e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 54.81  E-value: 3.35e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2217345598  792 LVLNWEEPCNNGSEILAYTIDLGDTS--------ITVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQFIKAKT 860
Cdd:cd00063     17 VTLSWTPPEDDGGPITGYVVEYREKGsgdwkeveVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 186-280 2.67e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 52.50  E-value: 2.67e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217345598  186 EKPQVSNIQARAVVLSWAPPVGLScGPHSGlsfpysYEVALSDKGRDGKYKI-IYSGEELECNLKDLRPATDYHVRVYAM 264
Cdd:cd00063      5 TNLRVTDVTSTSVTLSWTPPEDDG-GPITG------YVVEYREKGSGDWKEVeVTPGSETSYTLTGLKPGTEYEFRVRAV 77

                           90
                   ....*....|....*.
gi 2217345598  265 YNSVKGSCSEPVSFTT 280
Cdd:cd00063     78 NGGGESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 285-366 4.18e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 51.46  E-value: 4.18e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217345598   285 PECPFPPKLAHRSKSSLTLQWKAPIDNG--SKITNYLLEWDEgKRNSGFRQCFFGSQKHCKLTKLCPAMGYTFRLAARND 362
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGitGYIVGYRVEYRE-EGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNG 79


                    ....
gi 2217345598   363 IGTS 366
Cdd:smart00060   80 AGEG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 960-1033 5.19e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 48.65  E-value: 5.19e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2217345598  960 PPTIKAPRVTQLEGNSCEILWETVPSMKGDPVNYILQVLVGRESEYKQVYK--GEEATFQISGLQTNTDYRFRVCA 1033
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVtpGSETSYTLTGLKPGTEYEFRVRA 76
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 186-263 8.16e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 47.99  E-value: 8.16e-07
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2217345598   186 EKPQVSNIQARAVVLSWAPPVglscgPHSGLSFPYSYEVALSDKGRDGKyKIIYSGEELECNLKDLRPATDYHVRVYA 263
Cdd:smart00060    5 SNLRVTDVTSTSVTLSWEPPP-----DDGITGYIVGYRVEYREEGSEWK-EVNVTPSSTSYTLTGLKPGTEYEFRVRA 76
fn3 pfam00041
Fibronectin type III domain;
188-263 1.36e-06

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 47.41  E-value: 1.36e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2217345598  188 PQVSNIQARAVVLSWAPPVGLScGPHSGlsfpYSYEVALSDKGRDGKYKIIySGEELECNLKDLRPATDYHVRVYA 263
Cdd:pfam00041    6 LTVTDVTSTSLTVSWTPPPDGN-GPITG----YEVEYRPKNSGEPWNEITV-PGTTTSVTLTGLKPGTEYEVRVQA 75
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
920-1033 3.75e-06

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 51.16  E-value: 3.75e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217345598  920 TYKVQRLTEFTCYSFRIQAASEAGEGPFSETYTFsTTKSVPPTikAP---RVTQLEGNSCEILWETVPSMkgDPVNYILQ 996
Cdd:COG3401    193 VDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSV-TTPTTPPS--APtglTATADTPGSVTLSWDPVTES--DATGYRVY 267

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 2217345598  997 VLVGRESEYKQVYKGEEATFQISGLQTNTDYRFRVCA 1033
Cdd:COG3401    268 RSNSGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTA 304
fn3 pfam00041
Fibronectin type III domain;
960-1033 4.81e-06

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 45.87  E-value: 4.81e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2217345598  960 PPTIkaPRVTQLEGNSCEILWETVPSMKGDPVNYILQVLVGRESEYKQVY--KGEEATFQISGLQTNTDYRFRVCA 1033
Cdd:pfam00041    2 APSN--LTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGEPWNEItvPGTTTSVTLTGLKPGTEYEVRVQA 75
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 767-850 5.18e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 45.68  E-value: 5.18e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217345598   767 PDPVSTLCVLeeepldaypDSPSACLVLNWEEP--CNNGSEILAYTIDLGDTS------ITVGNTTMHVMKDLLPETTYR 838
Cdd:smart00060    1 PSPPSNLRVT---------DVTSTSVTLSWEPPpdDGITGYIVGYRVEYREEGsewkevNVTPSSTSYTLTGLKPGTEYE 71

                            90
                    ....*....|..
gi 2217345598   839 IRIQAINEIGAG 850
Cdd:smart00060   72 FRVRAVNGAGEG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 960-1033 1.99e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 41.06  E-value: 1.99e-04
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2217345598   960 PPTIKAPRVTQLEGNSCEILWETVPSmkGDPVNYILQVLV---GRESEYKQVYKGEEAT-FQISGLQTNTDYRFRVCA 1033
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPD--DGITGYIVGYRVeyrEEGSEWKEVNVTPSSTsYTLTGLKPGTEYEFRVRA 76
 
Name Accession Description Interval E-value
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
443-773 1.04e-20

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 97.77  E-value: 1.04e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217345598  443 NLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGPPTrPLVKGPVTSHGFSVKWDPPKDNGGSEilkYLLEItdGNS 522
Cdd:COG3401    198 DIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPT-GLTATADTPGSVTLSWDPVTESDATG---YRVYR--SNS 271

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217345598  523 EANQWEVAYSGSATEYTFTHLKPGT--LYKLRAcCISTGGHSQCSESLPVRTLSIAPGqcrPPRVL--GRPKHKEVHLEW 598
Cdd:COG3401    272 GDGPFTKVATVTTTSYTDTGLTNGTtyYYRVTA-VDAAGNESAPSNVVSVTTDLTPPA---APSGLtaTAVGSSSITLSW 347

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217345598  599 DvPASESGceVSEYSVEMTEPEDVASEVYH--GPELECTVGNLLPGTVYRFRVRALNDGG-YGPYSD-VSEITTAAGPPG 674
Cdd:COG3401    348 T-ASSDAD--VTGYNVYRSTSGGGTYTKIAetVTTTSYTDTGLTPGTTYYYKVTAVDAAGnESAPSEeVSATTASAASGE 424

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217345598  675 QCKAPCISCTPDGCVLVGWESPDSSGADISEYRLEWGEDEESLELiyHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPY 754
Cdd:COG3401    425 SLTASVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVP--FTTTSSTVTATTTDTTTANLSVTTGSLVGGSGA 502

                          330
                   ....*....|....*....
gi 2217345598  755 SELVLCQTPASAPDPVSTL 773
Cdd:COG3401    503 SSVTNSVSVIGASAAAAVG 521
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
472-854 8.96e-20

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 94.68  E-value: 8.96e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217345598  472 TTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYSGSATEYTFTHLKPGTLYKL 551
Cdd:COG3401    128 ATAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATTSLTVTSTTLVDGGGDIEPGTTYYY 207

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217345598  552 RACCISTGGHSQCSESLPVRTLSIAPGQcrPPRVLGRPK-HKEVHLEWDvPASESGceVSEYSVEMTEPEDVA-SEVYHG 629
Cdd:COG3401    208 RVAATDTGGESAPSNEVSVTTPTTPPSA--PTGLTATADtPGSVTLSWD-PVTESD--ATGYRVYRSNSGDGPfTKVATV 282

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217345598  630 PELECTVGNLLPGTVYRFRVRALN-DGGYGPYSDVSEITTAAGPPGqckAP----CISCTPDGCVLvGWEspDSSGADIS 704
Cdd:COG3401    283 TTTSYTDTGLTNGTTYYYRVTAVDaAGNESAPSNVVSVTTDLTPPA---APsgltATAVGSSSITL-SWT--ASSDADVT 356

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217345598  705 EYRLEWGEDEE-SLELIYHG-TDTRFEIRDLLPAAQYCCRLQAFNQAG-AGPYSELVLcQTPASAPDPVSTLCVLEEEPL 781
Cdd:COG3401    357 GYNVYRSTSGGgTYTKIAETvTTTSYTDTGLTPGTTYYYKVTAVDAAGnESAPSEEVS-ATTASAASGESLTASVDAVPL 435

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2217345598  782 DAYPDSPSACLVLNWeepcNNGSEILAYTIDLGDTSITVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQ 854
Cdd:COG3401    436 TDVAGATAAASAASN----PGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTANLSVTTGSLVGGSGASS 504
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
353-578 5.11e-17

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 86.21  E-value: 5.11e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217345598  353 YTFRLAARNDIGTSGYSQEVVCYTLGNIPQMPSAPRLVRAGITWVTLQWSKPEGcspEEVITYTLEIQEDENDNlFHPKY 432
Cdd:COG3401    205 YYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTGLTATADTPGSVTLSWDPVTE---SDATGYRVYRSNSGDGP-FTKVA 280

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217345598  433 TGEDLTCTVKNLKRSTQYKFRLTASNTEG-KSCPSEVLVCTTSPDRPGPPTrPLVKGPVTSHGFSVKWDPPKDNGgseIL 511
Cdd:COG3401    281 TVTTTSYTDTGLTNGTTYYYRVTAVDAAGnESAPSNVVSVTTDLTPPAAPS-GLTATAVGSSSITLSWTASSDAD---VT 356

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217345598  512 KYLLEItdGNSEANQWE-VAYSGSATEYTFTHLKPGT--LYKLRAcCISTGGHSQCSESLPVRTLSIAPG 578
Cdd:COG3401    357 GYNVYR--STSGGGTYTkIAETVTTTSYTDTGLTPGTtyYYKVTA-VDAAGNESAPSEEVSATTASAASG 423
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
635-969 6.98e-17

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 85.44  E-value: 6.98e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217345598  635 TVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGPPGqckAPC----ISCTPDGcVLVGWESPDSSGADisEYRLEW 710
Cdd:COG3401    195 GGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPS---APTgltaTADTPGS-VTLSWDPVTESDAT--GYRVYR 268

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217345598  711 GEDE-ESLELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQAG-AGPYSELVLCQTPASAPDPVSTlcvleeepLDAYPDSP 788
Cdd:COG3401    269 SNSGdGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGnESAPSNVVSVTTDLTPPAAPSG--------LTATAVGS 340

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217345598  789 SAcLVLNWEEpcNNGSEILAYTI------DLGDTSI-TVGNTTMHVMKDLLPETTYRIRIQAINEIG-AGPFSQFIKAKT 860
Cdd:COG3401    341 SS-ITLSWTA--SSDADVTGYNVyrstsgGGTYTKIaETVTTTSYTDTGLTPGTTYYYKVTAVDAAGnESAPSEEVSATT 417

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217345598  861 RPLPPLPPRLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKRFISIYRGPSHTYKVQRLTEFTCYSFRIQAAS 940
Cdd:COG3401    418 ASAASGESLTASVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTANLSVTTGSLV 497

                          330       340
                   ....*....|....*....|....*....
gi 2217345598  941 eAGEGPFSETYTFSTTKSVPPTIKAPRVT 969
Cdd:COG3401    498 -GGSGASSVTNSVSVIGASAAAAVGGAPD 525
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 478-572 6.45e-14

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 68.29  E-value: 6.45e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217345598  478 PGPPTRPLVKgPVTSHGFSVKWDPPKDNGGsEILKYLLEITDGNSEANQWEVAYSGSATEYTFTHLKPGTLYKLRACCIS 557
Cdd:cd00063      1 PSPPTNLRVT-DVTSTSVTLSWTPPEDDGG-PITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVN 78

                           90
                   ....*....|....*
gi 2217345598  558 TGGHSQCSESLPVRT 572
Cdd:cd00063     79 GGGESPPSESVTVTT 93
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
253-549 1.03e-13

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 75.42  E-value: 1.03e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217345598  253 PATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPPKLAHRSKSSLTLQWKAPIDNGskITNYLLEWDEGKrNSGFR 332
Cdd:COG3401    201 PGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTGLTATADTPGSVTLSWDPVTESD--ATGYRVYRSNSG-DGPFT 277

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217345598  333 QCFFGSQKHCKLTKLCPAMGYTFRLAARNDIGT-SGYSQEVVCYTLGNIPQMPSAPRLVRAGITWVTLQWSKPegcSPEE 411
Cdd:COG3401    278 KVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGNeSAPSNVVSVTTDLTPPAAPSGLTATAVGSSSITLSWTAS---SDAD 354

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217345598  412 VITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEG-KSCPSEVLVCTTSPDRPGPPT---RPLVK 487
Cdd:COG3401    355 VTGYNVYRSTSGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAVDAAGnESAPSEEVSATTASAASGESLtasVDAVP 434

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2217345598  488 GPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYSGSATEYTFTHLKPGTLY 549
Cdd:COG3401    435 LTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTANLSVTTGSL 496
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 577-668 1.63e-13

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 67.14  E-value: 1.63e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217345598  577 PGQCRPPRVLGRPKHkEVHLEWDVPASESGcEVSEYSVEMTEPEDVASEVY---HGPELECTVGNLLPGTVYRFRVRALN 653
Cdd:cd00063      1 PSPPTNLRVTDVTST-SVTLSWTPPEDDGG-PITGYVVEYREKGSGDWKEVevtPGSETSYTLTGLKPGTEYEFRVRAVN 78

                           90
                   ....*....|....*
gi 2217345598  654 DGGYGPYSDVSEITT 668
Cdd:cd00063     79 GGGESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 478-562 3.10e-12

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 63.40  E-value: 3.10e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217345598   478 PGPPTRPLVKgPVTSHGFSVKWDPPK-DNGGSEILKYllEITDGNSEANQWEVAYSGSATEYTFTHLKPGTLYKLRACCI 556
Cdd:smart00060    1 PSPPSNLRVT-DVTSTSVTLSWEPPPdDGITGYIVGY--RVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAV 77


                    ....*.
gi 2217345598   557 STGGHS 562
Cdd:smart00060   78 NGAGEG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 384-473 3.34e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 63.67  E-value: 3.34e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217345598  384 PSAPRLVRA---GITWVTLQWSKPEGcSPEEVITYTLEIQEDENDNLFH-PKYTGEDLTCTVKNLKRSTQYKFRLTASNT 459
Cdd:cd00063      1 PSPPTNLRVtdvTSTSVTLSWTPPED-DGGPITGYVVEYREKGSGDWKEvEVTPGSETSYTLTGLKPGTEYEFRVRAVNG 79

                           90
                   ....*....|....
gi 2217345598  460 EGKSCPSEVLVCTT 473
Cdd:cd00063     80 GGESPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 285-376 7.35e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 62.51  E-value: 7.35e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217345598  285 PECPFPPKLAHRSKSSLTLQWKAPIDNGSKITNYLLEWDEgKRNSGFRQC--FFGSQKHCKLTKLCPAMGYTFRLAARND 362
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYRE-KGSGDWKEVevTPGSETSYTLTGLKPGTEYEFRVRAVNG 79

                           90
                   ....*....|....
gi 2217345598  363 IGTSGYSQEVVCYT 376
Cdd:cd00063     80 GGESPPSESVTVTT 93
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
833-1033 3.09e-11

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 67.33  E-value: 3.09e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217345598  833 PETTYRIRIQAINEIGAGPFSQFIKAKTRPLPPLP-PRLECAAAGPQSLKLKWgDSNSKTHAAEDIVYtlQLEDRNKRFI 911
Cdd:COG3401    201 PGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSApTGLTATADTPGSVTLSW-DPVTESDATGYRVY--RSNSGDGPFT 277

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217345598  912 SIYRGPSHTYKVQRLTEFTCYSFRIQAASEAG-EGPFSETYTFSTTKSVPPTIKAPRVTQLEGNSCEILWETVPSmkGDP 990
Cdd:COG3401    278 KVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGnESAPSNVVSVTTDLTPPAAPSGLTATAVGSSSITLSWTASSD--ADV 355

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....
gi 2217345598  991 VNYILQVLVGRESEYKQVYKGEEAT-FQISGLQTNTDYRFRVCA 1033
Cdd:COG3401    356 TGYNVYRSTSGGGTYTKIAETVTTTsYTDTGLTPGTTYYYKVTA 399
fn3 pfam00041
Fibronectin type III domain;
288-369 6.24e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 59.74  E-value: 6.24e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217345598  288 PFPPKLAHRSKSSLTLQWKAPIDNGSKITNYLLEWDEGKRNSGFRQCF-FGSQKHCKLTKLCPAMGYTFRLAARNDIGTS 366
Cdd:pfam00041    3 PSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGEPWNEITvPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEG 82


                   ...
gi 2217345598  367 GYS 369
Cdd:pfam00041   83 PPS 85
fn3 pfam00041
Fibronectin type III domain;
479-563 1.24e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 58.58  E-value: 1.24e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217345598  479 GPPTRPLVKgPVTSHGFSVKWDPPKDnGGSEILKYLLEITDGNSEANQWEVAYSGSATEYTFTHLKPGTLYKLRACCIST 558
Cdd:pfam00041    1 SAPSNLTVT-DVTSTSLTVSWTPPPD-GNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNG 78


                   ....*
gi 2217345598  559 GGHSQ 563
Cdd:pfam00041   79 GGEGP 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 673-762 1.41e-10

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 59.05  E-value: 1.41e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217345598  673 PGQCKAPCISCTPDGCVLVGWESPDSSGADISEYRLEWGEDEESLELIY---HGTDTRFEIRDLLPAAQYCCRLQAFNQA 749
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVevtPGSETSYTLTGLKPGTEYEFRVRAVNGG 80

                           90
                   ....*....|...
gi 2217345598  750 GAGPYSELVLCQT 762
Cdd:cd00063     81 GESPPSESVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
792-853 4.14e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 57.42  E-value: 4.14e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217345598  792 LVLNWEEPCNNGSEILAYTIDL-------GDTSITVGNTTMHVM-KDLLPETTYRIRIQAINEIGAGPFS 853
Cdd:pfam00041   16 LTVSWTPPPDGNGPITGYEVEYrpknsgePWNEITVPGTTTSVTlTGLKPGTEYEVRVQAVNGGGEGPPS 85
fn3 pfam00041
Fibronectin type III domain;
593-661 6.95e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 56.65  E-value: 6.95e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2217345598  593 EVHLEWDVPASESGcEVSEYSVE---MTEPEDVASEVYHGPELECTVGNLLPGTVYRFRVRALNDGGYGPYS 661
Cdd:pfam00041   15 SLTVSWTPPPDGNG-PITGYEVEyrpKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 577-658 1.00e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 56.08  E-value: 1.00e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217345598   577 PGQCRPPRVLGRPKHkEVHLEWDVPASE-SGCEVSEYSVEMTEPEDVASEVYHGP-ELECTVGNLLPGTVYRFRVRALND 654
Cdd:smart00060    1 PSPPSNLRVTDVTST-SVTLSWEPPPDDgITGYIVGYRVEYREEGSEWKEVNVTPsSTSYTLTGLKPGTEYEFRVRAVNG 79


                    ....
gi 2217345598   655 GGYG 658
Cdd:smart00060   80 AGEG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 792-860 3.35e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 54.81  E-value: 3.35e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2217345598  792 LVLNWEEPCNNGSEILAYTIDLGDTS--------ITVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQFIKAKT 860
Cdd:cd00063     17 VTLSWTPPEDDGGPITGYVVEYREKGsgdwkeveVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPSESVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
689-755 4.53e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 54.34  E-value: 4.53e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217345598  689 VLVGWESPDSSGADISEYRLEW---GEDEESLELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPYS 755
Cdd:pfam00041   16 LTVSWTPPPDGNGPITGYEVEYrpkNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEGPPS 85
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
189-541 9.46e-09

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 59.63  E-value: 9.46e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217345598  189 QVSNIQARAVVLSWAPPvglscgPHSGLSfpySYEVALSDKGrDGKYKIIYSGEELECNLKDLRPATDYHVRVYAM-YNS 267
Cdd:COG3401    240 TATADTPGSVTLSWDPV------TESDAT---GYRVYRSNSG-DGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVdAAG 309

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217345598  268 VKGSCSEPVSFTTHSCAPECPFPPKLAHRSKSSLTLQWKAPIDNGskITNYLLEWDEGKrNSGFRQ-CFFGSQKHCKLTK 346
Cdd:COG3401    310 NESAPSNVVSVTTDLTPPAAPSGLTATAVGSSSITLSWTASSDAD--VTGYNVYRSTSG-GGTYTKiAETVTTTSYTDTG 386

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217345598  347 LCPAMGYTFRLAARNDIGTSGYSQEVVCYTLGNIPQMPSAPRLVRAGITWVTLQWSkpEGCSPEEVITYTLEIQEDENDN 426
Cdd:COG3401    387 LTPGTTYYYKVTAVDAAGNESAPSEEVSATTASAASGESLTASVDAVPLTDVAGAT--AAASAASNPGVSAAVLADGGDT 464

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217345598  427 LFHPKYTGEDLTcTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGPPTRPLVKGPVTShgfSVKWDPPKDNG 506
Cdd:COG3401    465 GNAVPFTTTSST-VTATTTDTTTANLSVTTGSLVGGSGASSVTNSVSVIGASAAAAVGGAPDGTPN---VTGASPVTVGA 540

                          330       340       350
                   ....*....|....*....|....*....|....*
gi 2217345598  507 GSEILKYLLEITDGNSEANQWEVAYSGSATEYTFT 541
Cdd:COG3401    541 STGDVLITDLVSLTTSASSSVSGAGLGSGNLYLIT 575
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 186-280 2.67e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 52.50  E-value: 2.67e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217345598  186 EKPQVSNIQARAVVLSWAPPVGLScGPHSGlsfpysYEVALSDKGRDGKYKI-IYSGEELECNLKDLRPATDYHVRVYAM 264
Cdd:cd00063      5 TNLRVTDVTSTSVTLSWTPPEDDG-GPITG------YVVEYREKGSGDWKEVeVTPGSETSYTLTGLKPGTEYEFRVRAV 77

                           90
                   ....*....|....*.
gi 2217345598  265 YNSVKGSCSEPVSFTT 280
Cdd:cd00063     78 NGGGESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 285-366 4.18e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 51.46  E-value: 4.18e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217345598   285 PECPFPPKLAHRSKSSLTLQWKAPIDNG--SKITNYLLEWDEgKRNSGFRQCFFGSQKHCKLTKLCPAMGYTFRLAARND 362
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGitGYIVGYRVEYRE-EGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNG 79


                    ....
gi 2217345598   363 IGTS 366
Cdd:smart00060   80 AGEG 83
COG4733 COG4733
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
496-692 6.47e-08

Phage-related protein, tail protein J [Mobilome: prophages, transposons];


Pssm-ID: 443767 [Multi-domain]  Cd Length: 978  Bit Score: 56.88  E-value: 6.47e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217345598  496 SVKWDPPKDNGGseilkYLLEITDGNSEanqWEVAYSGSATEYTFTHLKPGTlYKLRACCISTGGHSQCSESLPVRTLS- 574
Cdd:COG4733    555 TVSWDAPAGAVA-----YEVEWRRDDGN---WVSVPRTSGTSFEVPGIYAGD-YEVRVRAINALGVSSAWAASSETTVTg 625

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217345598  575 -IAPgqcrPPRVLG---RPKHKEVHLEWDVPAsesGCEVSEYSVEMTEPEDVAS---EVYHGPELECTVGNLLPGTVYRF 647
Cdd:COG4733    626 kTAP----PPAPTGltaTGGLGGITLSWSFPV---DADTLRTEIRYSTTGDWASatvAQALYPGNTYTLAGLKAGQTYYY 698

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*.
gi 2217345598  648 RVRALNDGG-YGPYSDVSEITTAAGPPGQCKAPCISCTPDGCVLVG 692
Cdd:COG4733    699 RARAVDRSGnVSAWWVSGQASADAAGILDAITGQILETELGQELDA 744
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 384-463 4.76e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 48.38  E-value: 4.76e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217345598   384 PSAPRLVRA---GITWVTLQWSKPEGCSPEE-VITYTLEIQEDENDNLFHPKyTGEDLTCTVKNLKRSTQYKFRLTASNT 459
Cdd:smart00060    1 PSPPSNLRVtdvTSTSVTLSWEPPPDDGITGyIVGYRVEYREEGSEWKEVNV-TPSSTSYTLTGLKPGTEYEFRVRAVNG 79


                    ....
gi 2217345598   460 EGKS 463
Cdd:smart00060   80 AGEG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 960-1033 5.19e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 48.65  E-value: 5.19e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2217345598  960 PPTIKAPRVTQLEGNSCEILWETVPSMKGDPVNYILQVLVGRESEYKQVYK--GEEATFQISGLQTNTDYRFRVCA 1033
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVtpGSETSYTLTGLKPGTEYEFRVRA 76
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 673-752 7.18e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 47.99  E-value: 7.18e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217345598   673 PGQCKAPCISCTPDGCVLVGWESPDSSGAD--ISEYRLEWGE-DEESLELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQA 749
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGITgyIVGYRVEYREeGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80


                    ...
gi 2217345598   750 GAG 752
Cdd:smart00060   81 GEG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 186-263 8.16e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 47.99  E-value: 8.16e-07
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2217345598   186 EKPQVSNIQARAVVLSWAPPVglscgPHSGLSFPYSYEVALSDKGRDGKyKIIYSGEELECNLKDLRPATDYHVRVYA 263
Cdd:smart00060    5 SNLRVTDVTSTSVTLSWEPPP-----DDGITGYIVGYRVEYREEGSEWK-EVNVTPSSTSYTLTGLKPGTEYEFRVRA 76
fn3 pfam00041
Fibronectin type III domain;
188-263 1.36e-06

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 47.41  E-value: 1.36e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2217345598  188 PQVSNIQARAVVLSWAPPVGLScGPHSGlsfpYSYEVALSDKGRDGKYKIIySGEELECNLKDLRPATDYHVRVYA 263
Cdd:pfam00041    6 LTVTDVTSTSLTVSWTPPPDGN-GPITG----YEVEYRPKNSGEPWNEITV-PGTTTSVTLTGLKPGTEYEVRVQA 75
fn3 pfam00041
Fibronectin type III domain;
384-466 1.42e-06

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 47.41  E-value: 1.42e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217345598  384 PSAPRLVRAGITWVTLQWSKPEGCSpEEVITYTLEIQE-DENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGK 462
Cdd:pfam00041    3 PSNLTVTDVTSTSLTVSWTPPPDGN-GPITGYEVEYRPkNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGE 81


                   ....
gi 2217345598  463 SCPS 466
Cdd:pfam00041   82 GPPS 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 876-955 1.42e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 47.49  E-value: 1.42e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217345598  876 GPQSLKLKWgdSNSKTHAAEDIVYTLQLEDRNK---RFISIYRGPSHTYKVQRLTEFTCYSFRIQAASEAGEGPFSETYT 952
Cdd:cd00063     13 TSTSVTLSW--TPPEDDGGPITGYVVEYREKGSgdwKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPSESVT 90


                   ...
gi 2217345598  953 FST 955
Cdd:cd00063     91 VTT 93
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
920-1033 3.75e-06

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 51.16  E-value: 3.75e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217345598  920 TYKVQRLTEFTCYSFRIQAASEAGEGPFSETYTFsTTKSVPPTikAP---RVTQLEGNSCEILWETVPSMkgDPVNYILQ 996
Cdd:COG3401    193 VDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSV-TTPTTPPS--APtglTATADTPGSVTLSWDPVTES--DATGYRVY 267

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 2217345598  997 VLVGRESEYKQVYKGEEATFQISGLQTNTDYRFRVCA 1033
Cdd:COG3401    268 RSNSGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTA 304
fn3 pfam00041
Fibronectin type III domain;
960-1033 4.81e-06

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 45.87  E-value: 4.81e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2217345598  960 PPTIkaPRVTQLEGNSCEILWETVPSMKGDPVNYILQVLVGRESEYKQVY--KGEEATFQISGLQTNTDYRFRVCA 1033
Cdd:pfam00041    2 APSN--LTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGEPWNEItvPGTTTSVTLTGLKPGTEYEVRVQA 75
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 767-850 5.18e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 45.68  E-value: 5.18e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217345598   767 PDPVSTLCVLeeepldaypDSPSACLVLNWEEP--CNNGSEILAYTIDLGDTS------ITVGNTTMHVMKDLLPETTYR 838
Cdd:smart00060    1 PSPPSNLRVT---------DVTSTSVTLSWEPPpdDGITGYIVGYRVEYREEGsewkevNVTPSSTSYTLTGLKPGTEYE 71

                            90
                    ....*....|..
gi 2217345598   839 IRIQAINEIGAG 850
Cdd:smart00060   72 FRVRAVNGAGEG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 874-945 8.68e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 42.22  E-value: 8.68e-05
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2217345598   874 AAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKRFISIYRGPSHT-YKVQRLTEFTCYSFRIQAASEAGEG 945
Cdd:smart00060   11 DVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWKEVNVTPSSTsYTLTGLKPGTEYEFRVRAVNGAGEG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 960-1033 1.99e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 41.06  E-value: 1.99e-04
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2217345598   960 PPTIKAPRVTQLEGNSCEILWETVPSmkGDPVNYILQVLV---GRESEYKQVYKGEEAT-FQISGLQTNTDYRFRVCA 1033
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPD--DGITGYIVGYRVeyrEEGSEWKEVNVTPSSTsYTLTGLKPGTEYEFRVRA 76
COG4733 COG4733
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
397-560 1.06e-03

Phage-related protein, tail protein J [Mobilome: prophages, transposons];


Pssm-ID: 443767 [Multi-domain]  Cd Length: 978  Bit Score: 43.40  E-value: 1.06e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217345598  397 VTLQWSKPEGcspeeVITYTLEIQEDenDNLFHPKYTGEDLTCTVKNLKrSTQYKFRLTASNTEGKSCPSEVLVCTTSPD 476
Cdd:COG4733    554 LTVSWDAPAG-----AVAYEVEWRRD--DGNWVSVPRTSGTSFEVPGIY-AGDYEVRVRAINALGVSSAWAASSETTVTG 625

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217345598  477 RPGPPTRP----LVKGPvtsHGFSVKWDPPKDnggSEILKYLLEITDGNSEANQWEVAYSGSATEYTFTHLKPGTLYKLR 552
Cdd:COG4733    626 KTAPPPAPtgltATGGL---GGITLSWSFPVD---ADTLRTEIRYSTTGDWASATVAQALYPGNTYTLAGLKAGQTYYYR 699


                   ....*...
gi 2217345598  553 ACCISTGG 560
Cdd:COG4733    700 ARAVDRSG 707
fn3 pfam00041
Fibronectin type III domain;
876-948 3.45e-03

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 37.78  E-value: 3.45e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2217345598  876 GPQSLKLKWgdSNSKTHAAEDIVYTLQLEDRNK------RFISiyrGPSHTYKVQRLTEFTCYSFRIQAASEAGEGPFS 948
Cdd:pfam00041   12 TSTSLTVSW--TPPPDGNGPITGYEVEYRPKNSgepwneITVP---GTTTSVTLTGLKPGTEYEVRVQAVNGGGEGPPS 85
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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