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Conserved domains on  [gi|2459768620|ref|XP_054118102|]
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uncharacterized protein EYB26_002822 [Talaromyces marneffei]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 10077586)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 112-408 1.09e-83

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 259.19  E-value: 1.09e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2459768620 112 LESHRNTINCLAFHPKFSSIASGSDDCMIKIWDWELGELETTLKGHTRAVLDVDYGNtqSGVLLASCSSDLSIKIWNpLE 191
Cdd:cd00200     5 LKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASA--DGTYLASGSSDKTIRLWD-LE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2459768620 192 DYKNIRTLLGHEHSVSAVRFIPGRNLLTSASRDKDLRIWDVTTGFCVKTIQGHSGWVRDVCPSFDGNYLFSAGDDVTARL 271
Cdd:cd00200    82 TGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2459768620 272 WDITNISnpeAKLTMVGHDHVIECCAVAPqTSYQYLapmaglkkealskmsaveftaTGSRDKTIKVWD-RRGSCLMTLV 350
Cdd:cd00200   162 WDLRTGK---CVATLTGHTGEVNSVAFSP-DGEKLL---------------------SSSSDGTIKLWDlSTGKCLGTLR 216

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2459768620 351 GHDNWVRAIVFHPGGKYLLSASDDKSIRCWDLsQDGKCVKTLSdAHGRFVTCLRWAPS 408
Cdd:cd00200   217 GHENGVNSVAFSPDGYLLASGSEDGTIRVWDL-RTGECVQTLS-GHTNSVTSLAWSPD 272
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 112-408 1.09e-83

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 259.19  E-value: 1.09e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2459768620 112 LESHRNTINCLAFHPKFSSIASGSDDCMIKIWDWELGELETTLKGHTRAVLDVDYGNtqSGVLLASCSSDLSIKIWNpLE 191
Cdd:cd00200     5 LKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASA--DGTYLASGSSDKTIRLWD-LE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2459768620 192 DYKNIRTLLGHEHSVSAVRFIPGRNLLTSASRDKDLRIWDVTTGFCVKTIQGHSGWVRDVCPSFDGNYLFSAGDDVTARL 271
Cdd:cd00200    82 TGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2459768620 272 WDITNISnpeAKLTMVGHDHVIECCAVAPqTSYQYLapmaglkkealskmsaveftaTGSRDKTIKVWD-RRGSCLMTLV 350
Cdd:cd00200   162 WDLRTGK---CVATLTGHTGEVNSVAFSP-DGEKLL---------------------SSSSDGTIKLWDlSTGKCLGTLR 216

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2459768620 351 GHDNWVRAIVFHPGGKYLLSASDDKSIRCWDLsQDGKCVKTLSdAHGRFVTCLRWAPS 408
Cdd:cd00200   217 GHENGVNSVAFSPDGYLLASGSEDGTIRVWDL-RTGECVQTLS-GHTNSVTSLAWSPD 272
WD40 COG2319
WD40 repeat [General function prediction only];
112-407 2.38e-70

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 228.64  E-value: 2.38e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2459768620 112 LESHRNTINCLAFHPKFSSIASGSDDCMIKIWDWELGELETTLKGHTRAVLDVDYgnTQSGVLLASCSSDLSIKIWNpLE 191
Cdd:COG2319   116 LTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAF--SPDGKLLASGSDDGTVRLWD-LA 192

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2459768620 192 DYKNIRTLLGHEHSVSAVRFIPGRNLLTSASRDKDLRIWDVTTGFCVKTIQGHSGWVRDVCPSFDGNYLFSAGDDVTARL 271
Cdd:COG2319   193 TGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRL 272

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2459768620 272 WDItniSNPEAKLTMVGHDHVIECCAVAPQTsyQYLApmaglkkealskmsaveftaTGSRDKTIKVWDRR-GSCLMTLV 350
Cdd:COG2319   273 WDL---ATGELLRTLTGHSGGVNSVAFSPDG--KLLA--------------------SGSDDGTVRLWDLAtGKLLRTLT 327

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2459768620 351 GHDNWVRAIVFHPGGKYLLSASDDKSIRCWDLsQDGKCVKTLSdAHGRFVTCLRWAP 407
Cdd:COG2319   328 GHTGAVRSVAFSPDGKTLASGSDDGTVRLWDL-ATGELLRTLT-GHTGAVTSVAFSP 382
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 343-381 3.82e-10

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 55.01  E-value: 3.82e-10
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 2459768620  343 GSCLMTLVGHDNWVRAIVFHPGGKYLLSASDDKSIRCWD 381
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PTZ00420 PTZ00420
coronin; Provisional
 107-286 3.90e-10

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 61.89  E-value: 3.90e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2459768620 107 PARYSLESHRNTINCLAFHPKFSSI-ASGSDDCMIKIWDW--------ELGELETTLKGHTRAVLDVDYgNTQSGVLLAS 177
Cdd:PTZ00420   65 PPVIKLKGHTSSILDLQFNPCFSEIlASGSEDLTIRVWEIphndesvkEIKDPQCILKGHKKKISIIDW-NPMNYYIMCS 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2459768620 178 CSSDLSIKIWNPLEDYKNIRTLLghEHSVSAVRFIPGRNLLTSASRDKDLRIWDVTTGFCVKTIQGHSGWVRDVCPSFDG 257
Cdd:PTZ00420  144 SGFDSFVNIWDIENEKRAFQINM--PKKLSSLKWNIKGNLLSGTCVGKHMHIIDPRKQEIASSFHIHDGGKNTKNIWIDG 221

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 2459768620 258 -----NYL----FSAGDDVTARLWDITNISNPEAKLTM 286
Cdd:PTZ00420  222 lggddNYIlstgFSKNNMREMKLWDLKNTTSALVTMSI 259
WD40 pfam00400
WD domain, G-beta repeat;
343-381 5.20e-10

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 54.27  E-value: 5.20e-10
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2459768620 343 GSCLMTLVGHDNWVRAIVFHPGGKYLLSASDDKSIRCWD 381
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 112-408 1.09e-83

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 259.19  E-value: 1.09e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2459768620 112 LESHRNTINCLAFHPKFSSIASGSDDCMIKIWDWELGELETTLKGHTRAVLDVDYGNtqSGVLLASCSSDLSIKIWNpLE 191
Cdd:cd00200     5 LKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASA--DGTYLASGSSDKTIRLWD-LE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2459768620 192 DYKNIRTLLGHEHSVSAVRFIPGRNLLTSASRDKDLRIWDVTTGFCVKTIQGHSGWVRDVCPSFDGNYLFSAGDDVTARL 271
Cdd:cd00200    82 TGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2459768620 272 WDITNISnpeAKLTMVGHDHVIECCAVAPqTSYQYLapmaglkkealskmsaveftaTGSRDKTIKVWD-RRGSCLMTLV 350
Cdd:cd00200   162 WDLRTGK---CVATLTGHTGEVNSVAFSP-DGEKLL---------------------SSSSDGTIKLWDlSTGKCLGTLR 216

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2459768620 351 GHDNWVRAIVFHPGGKYLLSASDDKSIRCWDLsQDGKCVKTLSdAHGRFVTCLRWAPS 408
Cdd:cd00200   217 GHENGVNSVAFSPDGYLLASGSEDGTIRVWDL-RTGECVQTLS-GHTNSVTSLAWSPD 272
WD40 COG2319
WD40 repeat [General function prediction only];
112-407 2.38e-70

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 228.64  E-value: 2.38e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2459768620 112 LESHRNTINCLAFHPKFSSIASGSDDCMIKIWDWELGELETTLKGHTRAVLDVDYgnTQSGVLLASCSSDLSIKIWNpLE 191
Cdd:COG2319   116 LTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAF--SPDGKLLASGSDDGTVRLWD-LA 192

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2459768620 192 DYKNIRTLLGHEHSVSAVRFIPGRNLLTSASRDKDLRIWDVTTGFCVKTIQGHSGWVRDVCPSFDGNYLFSAGDDVTARL 271
Cdd:COG2319   193 TGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRL 272

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2459768620 272 WDItniSNPEAKLTMVGHDHVIECCAVAPQTsyQYLApmaglkkealskmsaveftaTGSRDKTIKVWDRR-GSCLMTLV 350
Cdd:COG2319   273 WDL---ATGELLRTLTGHSGGVNSVAFSPDG--KLLA--------------------SGSDDGTVRLWDLAtGKLLRTLT 327

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2459768620 351 GHDNWVRAIVFHPGGKYLLSASDDKSIRCWDLsQDGKCVKTLSdAHGRFVTCLRWAP 407
Cdd:COG2319   328 GHTGAVRSVAFSPDGKTLASGSDDGTVRLWDL-ATGELLRTLT-GHTGAVTSVAFSP 382
WD40 COG2319
WD40 repeat [General function prediction only];
109-383 4.00e-69

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 225.56  E-value: 4.00e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2459768620 109 RYSLESHRNTINCLAFHPKFSSIASGSDDCMIKIWDWELGELETTLKGHTRAVLDVDYgnTQSGVLLASCSSDLSIKIWN 188
Cdd:COG2319   155 LRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAF--SPDGKLLASGSADGTVRLWD 232

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2459768620 189 pLEDYKNIRTLLGHEHSVSAVRFIPGRNLLTSASRDKDLRIWDVTTGFCVKTIQGHSGWVRDVCPSFDGNYLFSAGDDVT 268
Cdd:COG2319   233 -LATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGT 311

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2459768620 269 ARLWDItniSNPEAKLTMVGHDHVIECCAVAPQTsyQYLApmaglkkealskmsaveftaTGSRDKTIKVWDRR-GSCLM 347
Cdd:COG2319   312 VRLWDL---ATGKLLRTLTGHTGAVRSVAFSPDG--KTLA--------------------SGSDDGTVRLWDLAtGELLR 366

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 2459768620 348 TLVGHDNWVRAIVFHPGGKYLLSASDDKSIRCWDLS 383
Cdd:COG2319   367 TLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
87-407 6.52e-69

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 224.79  E-value: 6.52e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2459768620  87 ATPTSLSKRNQDPASWLPKVPARYSLESHRNTINCLAFHPKFSSIASGSDDCMIKIWDWELGELETTLKGHTRAVLDVDY 166
Cdd:COG2319    49 ARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAF 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2459768620 167 gnTQSGVLLASCSSDLSIKIWNpLEDYKNIRTLLGHEHSVSAVRFIPGRNLLTSASRDKDLRIWDVTTGFCVKTIQGHSG 246
Cdd:COG2319   129 --SPDGKTLASGSADGTVRLWD-LATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTG 205

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2459768620 247 WVRDVCPSFDGNYLFSAGDDVTARLWDITnisNPEAKLTMVGHDHVIECCAVAPQTsyQYLapmaglkkealskmsavef 326
Cdd:COG2319   206 AVRSVAFSPDGKLLASGSADGTVRLWDLA---TGKLLRTLTGHSGSVRSVAFSPDG--RLL------------------- 261

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2459768620 327 tATGSRDKTIKVWDRR-GSCLMTLVGHDNWVRAIVFHPGGKYLLSASDDKSIRCWDLSqDGKCVKTLSdAHGRFVTCLRW 405
Cdd:COG2319   262 -ASGSADGTVRLWDLAtGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLA-TGKLLRTLT-GHTGAVRSVAF 338


                  ..
gi 2459768620 406 AP 407
Cdd:COG2319   339 SP 340
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 110-381 2.91e-67

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 216.82  E-value: 2.91e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2459768620 110 YSLESHRNTINCLAFHPKFSSIASGSDDCMIKIWDWELGELETTLKGHTRAVLDVDYgnTQSGVLLASCSSDLSIKIWNp 189
Cdd:cd00200    45 RTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAF--SPDGRILSSSSRDKTIKVWD- 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2459768620 190 LEDYKNIRTLLGHEHSVSAVRFIPGRNLLTSASRDKDLRIWDVTTGFCVKTIQGHSGWVRDVCPSFDGNYLFSAGDDVTA 269
Cdd:cd00200   122 VETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTI 201

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2459768620 270 RLWDitnISNPEAKLTMVGHDHVIECCAVAPQtsyQYLApmaglkkealskmsaveftATGSRDKTIKVWD-RRGSCLMT 348
Cdd:cd00200   202 KLWD---LSTGKCLGTLRGHENGVNSVAFSPD---GYLL-------------------ASGSEDGTIRVWDlRTGECVQT 256

                         250       260       270
                  ....*....|....*....|....*....|...
gi 2459768620 349 LVGHDNWVRAIVFHPGGKYLLSASDDKSIRCWD 381
Cdd:cd00200   257 LSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
87-407 9.98e-58

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 195.52  E-value: 9.98e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2459768620  87 ATPTSLSKRNQDPASWLPKVPARYSLESHRNTINCLAFHPKFSSIASGSDDCMIKIWDWELGELETTLKGHTRAVLDVDY 166
Cdd:COG2319     7 AALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAF 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2459768620 167 gnTQSGVLLASCSSDLSIKIWNpLEDYKNIRTLLGHEHSVSAVRFIPGRNLLTSASRDKDLRIWDVTTGFCVKTIQGHSG 246
Cdd:COG2319    87 --SPDGRLLASASADGTVRLWD-LATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSG 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2459768620 247 WVRDVCPSFDGNYLFSAGDDVTARLWDITnisNPEAKLTMVGHDHVIECCAVAPQTsyQYLapmaglkkealskmsavef 326
Cdd:COG2319   164 AVTSVAFSPDGKLLASGSDDGTVRLWDLA---TGKLLRTLTGHTGAVRSVAFSPDG--KLL------------------- 219

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2459768620 327 tATGSRDKTIKVWD-RRGSCLMTLVGHDNWVRAIVFHPGGKYLLSASDDKSIRCWDLsQDGKCVKTLsDAHGRFVTCLRW 405
Cdd:COG2319   220 -ASGSADGTVRLWDlATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDL-ATGELLRTL-TGHSGGVNSVAF 296


                  ..
gi 2459768620 406 AP 407
Cdd:COG2319   297 SP 298
WD40 COG2319
WD40 repeat [General function prediction only];
111-343 4.00e-51

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 178.18  E-value: 4.00e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2459768620 111 SLESHRNTINCLAFHPKFSSIASGSDDCMIKIWDWELGELETTLKGHTRAVLDVDYgnTQSGVLLASCSSDLSIKIWNpL 190
Cdd:COG2319   199 TLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAF--SPDGRLLASGSADGTVRLWD-L 275

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2459768620 191 EDYKNIRTLLGHEHSVSAVRFIPGRNLLTSASRDKDLRIWDVTTGFCVKTIQGHSGWVRDVCPSFDGNYLFSAGDDVTAR 270
Cdd:COG2319   276 ATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVR 355

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2459768620 271 LWDItniSNPEAKLTMVGHDHVIECCAVAPQTsyQYLApmaglkkealskmsaveftaTGSRDKTIKVWDRRG 343
Cdd:COG2319   356 LWDL---ATGELLRTLTGHTGAVTSVAFSPDG--RTLA--------------------SGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 195-408 2.67e-50

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 172.52  E-value: 2.67e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2459768620 195 NIRTLLGHEHSVSAVRFIPGRNLLTSASRDKDLRIWDVTTGFCVKTIQGHSGWVRDVCPSFDGNYLFSAGDDVTARLWDi 274
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWD- 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2459768620 275 tnISNPEAKLTMVGHDHVIECCAVAPQTsyQYLA-------------PMAGLKKEALSKMSAV---------EFTATGSR 332
Cdd:cd00200    80 --LETGECVRTLTGHTSYVSSVAFSPDG--RILSsssrdktikvwdvETGKCLTTLRGHTDWVnsvafspdgTFVASSSQ 155

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2459768620 333 DKTIKVWD-RRGSCLMTLVGHDNWVRAIVFHPGGKYLLSASDDKSIRCWDLSqDGKCVKTLSdAHGRFVTCLRWAPS 408
Cdd:cd00200   156 DGTIKLWDlRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLS-TGKCLGTLR-GHENGVNSVAFSPD 230
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 103-273 1.91e-44

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 157.11  E-value: 1.91e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2459768620 103 LPKVPARYSLESHRNTINCLAFHPKFSSIASGSDDCMIKIWDWELGELETTLKGHTRAVLDVDYgnTQSGVLLASCSSDL 182
Cdd:cd00200   122 VETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAF--SPDGEKLLSSSSDG 199

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2459768620 183 SIKIWNPLEDyKNIRTLLGHEHSVSAVRFIPGRNLLTSASRDKDLRIWDVTTGFCVKTIQGHSGWVRDVCPSFDGNYLFS 262
Cdd:cd00200   200 TIKLWDLSTG-KCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLAS 278

                         170
                  ....*....|.
gi 2459768620 263 AGDDVTARLWD 273
Cdd:cd00200   279 GSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
109-276 1.14e-43

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 158.15  E-value: 1.14e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2459768620 109 RYSLESHRNTINCLAFHPKFSSIASGSDDCMIKIWDWELGELETTLKGHTRAVLDVDYgnTQSGVLLASCSSDLSIKIWN 188
Cdd:COG2319   239 LRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAF--SPDGKLLASGSDDGTVRLWD 316

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2459768620 189 pLEDYKNIRTLLGHEHSVSAVRFIPGRNLLTSASRDKDLRIWDVTTGFCVKTIQGHSGWVRDVCPSFDGNYLFSAGDDVT 268
Cdd:COG2319   317 -LATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGT 395


                  ....*...
gi 2459768620 269 ARLWDITN 276
Cdd:COG2319   396 VRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
169-407 7.04e-36

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 136.96  E-value: 7.04e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2459768620 169 TQSGVLLASCSSDLSIKIWNPLEDyKNIRTLLGHEHSVSAVRFIPGRNLLTSASRDKDLRIWDVTTGFCVKTIQGHSGWV 248
Cdd:COG2319     3 SADGAALAAASADLALALLAAALG-ALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2459768620 249 RDVCPSFDGNYLFSAGDDVTARLWDitnISNPEAKLTMVGHDHVIECCAVAPQTSYqylapmaglkkealskmsavefTA 328
Cdd:COG2319    82 LSVAFSPDGRLLASASADGTVRLWD---LATGLLLRTLTGHTGAVRSVAFSPDGKT----------------------LA 136

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2459768620 329 TGSRDKTIKVWD-RRGSCLMTLVGHDNWVRAIVFHPGGKYLLSASDDKSIRCWDLsQDGKCVKTLsDAHGRFVTCLRWAP 407
Cdd:COG2319   137 SGSADGTVRLWDlATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDL-ATGKLLRTL-TGHTGAVRSVAFSP 214
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 343-381 3.82e-10

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 55.01  E-value: 3.82e-10
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 2459768620  343 GSCLMTLVGHDNWVRAIVFHPGGKYLLSASDDKSIRCWD 381
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PTZ00420 PTZ00420
coronin; Provisional
 107-286 3.90e-10

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 61.89  E-value: 3.90e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2459768620 107 PARYSLESHRNTINCLAFHPKFSSI-ASGSDDCMIKIWDW--------ELGELETTLKGHTRAVLDVDYgNTQSGVLLAS 177
Cdd:PTZ00420   65 PPVIKLKGHTSSILDLQFNPCFSEIlASGSEDLTIRVWEIphndesvkEIKDPQCILKGHKKKISIIDW-NPMNYYIMCS 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2459768620 178 CSSDLSIKIWNPLEDYKNIRTLLghEHSVSAVRFIPGRNLLTSASRDKDLRIWDVTTGFCVKTIQGHSGWVRDVCPSFDG 257
Cdd:PTZ00420  144 SGFDSFVNIWDIENEKRAFQINM--PKKLSSLKWNIKGNLLSGTCVGKHMHIIDPRKQEIASSFHIHDGGKNTKNIWIDG 221

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 2459768620 258 -----NYL----FSAGDDVTARLWDITNISNPEAKLTM 286
Cdd:PTZ00420  222 lggddNYIlstgFSKNNMREMKLWDLKNTTSALVTMSI 259
WD40 pfam00400
WD domain, G-beta repeat;
343-381 5.20e-10

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 54.27  E-value: 5.20e-10
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2459768620 343 GSCLMTLVGHDNWVRAIVFHPGGKYLLSASDDKSIRCWD 381
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 129-233 1.07e-08

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 57.40  E-value: 1.07e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2459768620 129 SSIASGSDDCMIKIWDWELGELETTLKGHTRAVLDVDYGNTQSgVLLASCSSDLSIKIWN-------------------- 188
Cdd:PLN00181  546 SQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADP-TLLASGSDDGSVKLWSinqgvsigtiktkaniccvq 624

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2459768620 189 -PLED--------------YKNIR-------TLLGHEHSVSAVRFIPGRNLLTSaSRDKDLRIWDVT 233
Cdd:PLN00181  625 fPSESgrslafgsadhkvyYYDLRnpklplcTMIGHSKTVSYVRFVDSSTLVSS-STDNTLKLWDLS 690
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 234-273 4.76e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.85  E-value: 4.76e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 2459768620  234 TGFCVKTIQGHSGWVRDVCPSFDGNYLFSAGDDVTARLWD 273
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 110-144 1.56e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 47.31  E-value: 1.56e-07
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2459768620  110 YSLESHRNTINCLAFHPKFSSIASGSDDCMIKIWD 144
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
110-144 2.74e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.57  E-value: 2.74e-07
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 2459768620 110 YSLESHRNTINCLAFHPKFSSIASGSDDCMIKIWD 144
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
235-273 6.17e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.80  E-value: 6.17e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2459768620 235 GFCVKTIQGHSGWVRDVCPSFDGNYLFSAGDDVTARLWD 273
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
194-231 2.25e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 44.26  E-value: 2.25e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 2459768620 194 KNIRTLLGHEHSVSAVRFIPGRNLLTSASRDKDLRIWD 231
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 194-231 2.42e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.23  E-value: 2.42e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2459768620  194 KNIRTLLGHEHSVSAVRFIPGRNLLTSASRDKDLRIWD 231
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
 175-273 1.22e-05

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 47.58  E-value: 1.22e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2459768620 175 LASCSSDLSIKIWN-PLEDYK-----NIRTLLGHEHSVSAVRFIP-GRNLLTSASRDKDLRIWDVTTGFCVKTIQGHSGW 247
Cdd:PTZ00421   91 LFTASEDGTIMGWGiPEEGLTqnisdPIVHLQGHTKKVGIVSFHPsAMNVLASAGADMVVNVWDVERGKAVEVIKCHSDQ 170

                          90       100
                  ....*....|....*....|....*.
gi 2459768620 248 VRDVCPSFDGNYLFSAGDDVTARLWD 273
Cdd:PTZ00421  171 ITSLEWNLDGSLLCTTSKDKKLNIID 196
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 215-383 2.43e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 47.00  E-value: 2.43e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2459768620 215 RNLLTSASRDKDLRIWDVTTGFCVKTIQGHSG--WVRDVcPSFDGNYLFSAGDDVTARLWDIT---NISNPEAKLTMvgh 289
Cdd:PLN00181  545 KSQVASSNFEGVVQVWDVARSQLVTEMKEHEKrvWSIDY-SSADPTLLASGSDDGSVKLWSINqgvSIGTIKTKANI--- 620

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2459768620 290 dhvieCCAVAPQTSYQYLApmaglkkealskmsaveftaTGSRDKTIKVWDRRGS--CLMTLVGHDNWVRAIVFhPGGKY 367
Cdd:PLN00181  621 -----CCVQFPSESGRSLA--------------------FGSADHKVYYYDLRNPklPLCTMIGHSKTVSYVRF-VDSST 674

                         170
                  ....*....|....*.
gi 2459768620 368 LLSASDDKSIRCWDLS 383
Cdd:PLN00181  675 LVSSSTDNTLKLWDLS 690
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 148-188 4.89e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.37  E-value: 4.89e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 2459768620  148 GELETTLKGHTRAVLDVDYgnTQSGVLLASCSSDLSIKIWN 188
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAF--SPDGKYLASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
 112-189 1.00e-04

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 44.50  E-value: 1.00e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2459768620 112 LESHRNTINCLAFHPKFSSI-ASGSDDCMIKIWDWELGELETTLKGHTRAVLDVDYgNTQsGVLLASCSSDLSIKIWNP 189
Cdd:PTZ00421  121 LQGHTKKVGIVSFHPSAMNVlASAGADMVVNVWDVERGKAVEVIKCHSDQITSLEW-NLD-GSLLCTTSKDKKLNIIDP 197
WD40 pfam00400
WD domain, G-beta repeat;
148-188 1.82e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.87  E-value: 1.82e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 2459768620 148 GELETTLKGHTRAVLDVDYgnTQSGVLLASCSSDLSIKIWN 188
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAF--SPDGKLLASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 154-246 3.52e-04

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 42.96  E-value: 3.52e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2459768620 154 LKGHTRAVLDVDYGNTQSGVLlASCSSDLSIKIWNpLEDYKNIRTLLGHEHSVSAVRFIPGRNLLTSASRDKDLRIWDVT 233
Cdd:PTZ00421  121 LQGHTKKVGIVSFHPSAMNVL-ASAGADMVVNVWD-VERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPR 198

                          90
                  ....*....|...
gi 2459768620 234 TGFCVKTIQGHSG 246
Cdd:PTZ00421  199 DGTIVSSVEAHAS 211
PTZ00421 PTZ00421
coronin; Provisional
 243-406 4.85e-04

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 42.57  E-value: 4.85e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2459768620 243 GHSGWVRDVC-PSFDGNYLFSAGDDVTARLWDItnisnPEAKLTMVGHDHVIECCAVAPQTSYQYLAPmaglkkealskm 321
Cdd:PTZ00421   73 GQEGPIIDVAfNPFDPQKLFTASEDGTIMGWGI-----PEEGLTQNISDPIVHLQGHTKKVGIVSFHP------------ 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2459768620 322 SAVEFTATGSRDKTIKVWD-RRGSCLMTLVGHDNWVRAIVFHPGGKYLLSASDDKSIRCWDlSQDGKCVKTL-SDAHGRF 399
Cdd:PTZ00421  136 SAMNVLASAGADMVVNVWDvERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIID-PRDGTIVSSVeAHASAKS 214


                  ....*..
gi 2459768620 400 VTCLrWA 406
Cdd:PTZ00421  215 QRCL-WA 220
Nup160 pfam11715
Nucleoporin Nup120/160; Nup120 is conserved from fungi to plants to humans, and is homologous ...
 204-241 3.34e-03

Nucleoporin Nup120/160; Nup120 is conserved from fungi to plants to humans, and is homologous with the Nup160 of vertebrates. The nuclear core complex, or NPC, mediates macromolecular transport across the nuclear envelope. Deletion of the NUP120 gene causes clustering of NPCs at one side of the nuclear envelope, moderate nucleolar fragmentation and slower cell growth. The vertebrate NPC is estimated to contain between 30 and 60 different proteins. most of which are not known. Two important ones in creating the nucleoporin basket are Nup98 and Nup153, and Nup120, in conjunction with Nup 133, interacts with these two and itself plays a role in mRNA export. Nup160, Nup133, Nup96, and Nup107 are all targets of phosphorylation. The phosphorylation sites are clustered mainly at the N-terminal regions of these proteins, which are predicted to be natively disordered. The entire Nup107-160 sub-complex is stable throughout the cell cycle, thus it seems unlikely that phosphorylation affects interactions within the Nup107-160 sub-complex, but rather that it regulates the association of the sub-complex with the NPC and other proteins.


Pssm-ID: 432020 [Multi-domain]  Cd Length: 540  Bit Score: 39.75  E-value: 3.34e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 2459768620 204 HSVSAVRFIPGRNLLTSASRDKDLRIWDVTTGFCVKTI 241
Cdd:pfam11715 223 SAAPAVTTVGGQNFLFTLSLDHTLRVWDLLTGKCLATI 260
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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