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Conserved domains on  [gi|2462552835|ref|XP_054170904|]
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proton-coupled folate transporter isoform X1 [Homo sapiens]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 22-361 0e+00

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17449:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 425  Bit Score: 554.80  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462552835  22 RGPVEPLVFLANFALVLQGPLTTQYLWHRFSADLGYNGTRQRG--GCSNRSADPTMQEVETLTSHWTLYMNVGGFLVGLF 99
Cdd:cd17449     1 SVTVEPVLFLAMFALVLQGPLTTQYLWDRLSADLGYNGTRTRGcaSNASTSADPLQQEVETLTAHWNLYINLGGFLVGLF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462552835 100 SSTLLGAWSDSVGRRPLLVLASLGLLLQALVSVFVVQLQLHVGYFVLGRILCALLGDFGGLLAASFASVADVSSSRSRTF 179
Cdd:cd17449    81 SVTLLGPWSDSVGRRPVLILPSLGLALQAAVYLLVMYLQLHVAYFLIGRILSGLLGDFNGILAGCFAYVADVSDRRSRTF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462552835 180 RMALLEASIGVAGMLASLLGGHWLRAQGYANPFWLALALLIAMTLYAAFCFGETLKEPKSTRLFTFRHHRSIVQLYVAPA 259
Cdd:cd17449   161 RVAVLEACLGLAGMLASIIGGQWRKAQGYINPFWLVLALNLAAALYAAFCVGESVKEPKSARLFTTRHHQSVVRLYVAPA 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462552835 260 PEKSRKHLALYSLAIFVVITVHFGAQDILTLYELSTPLCWDSKLIGYGSAAQHLPYLTSLLALKLLQYCLADAWVAEIGL 339
Cdd:cd17449   241 PNGSRRKLALYSLALFVVVTVHFGAKDLLVLYELSSPLCWDSDLIGYGSAAEHLTYLSSLLGLRLLQLCLEDTWVAEIGL 320

                         330       340
                  ....*....|....*....|..
gi 2462552835 340 AFNILGMVVFAFATITPLMFTG 361
Cdd:cd17449   321 ISNISGLVVISVATTTPLMFTG 342
 
Name Accession Description Interval E-value
MFS_SLC46A1_PCFT cd17449
Solute carrier family 46 member 1, also called Proton-coupled folate transporter, of the Major ...
 22-361 0e+00

Solute carrier family 46 member 1, also called Proton-coupled folate transporter, of the Major Facilitator Superfamily of transporters; Solute carrier family 46 member 1 (SLC46A1) is also called proton-coupled folate transporter (PCFT), G21, or heme carrier protein 1 (HCP1). It functions in two ways: as an intestinal proton-coupled high-affinity folate transporter that facilitates the absorption of folates across the brush-border membrane of the small intestine; and as an intestinal heme transporter which mediates heme uptake from the gut lumen into duodenal epithelial cells. It displays a higher affinity for folate than heme. It is also expressed in the choroid plexus and is required for transport of folates into the cerebrospinal fluid. Loss of function mutations in the SLC46A1 gene results in the autosomal recessive disorder "hereditary folate malabsorption" (HFM), characterized by severe systemic and cerebral folate deficiency. SLC46A1 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341007 [Multi-domain]  Cd Length: 425  Bit Score: 554.80  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462552835  22 RGPVEPLVFLANFALVLQGPLTTQYLWHRFSADLGYNGTRQRG--GCSNRSADPTMQEVETLTSHWTLYMNVGGFLVGLF 99
Cdd:cd17449     1 SVTVEPVLFLAMFALVLQGPLTTQYLWDRLSADLGYNGTRTRGcaSNASTSADPLQQEVETLTAHWNLYINLGGFLVGLF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462552835 100 SSTLLGAWSDSVGRRPLLVLASLGLLLQALVSVFVVQLQLHVGYFVLGRILCALLGDFGGLLAASFASVADVSSSRSRTF 179
Cdd:cd17449    81 SVTLLGPWSDSVGRRPVLILPSLGLALQAAVYLLVMYLQLHVAYFLIGRILSGLLGDFNGILAGCFAYVADVSDRRSRTF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462552835 180 RMALLEASIGVAGMLASLLGGHWLRAQGYANPFWLALALLIAMTLYAAFCFGETLKEPKSTRLFTFRHHRSIVQLYVAPA 259
Cdd:cd17449   161 RVAVLEACLGLAGMLASIIGGQWRKAQGYINPFWLVLALNLAAALYAAFCVGESVKEPKSARLFTTRHHQSVVRLYVAPA 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462552835 260 PEKSRKHLALYSLAIFVVITVHFGAQDILTLYELSTPLCWDSKLIGYGSAAQHLPYLTSLLALKLLQYCLADAWVAEIGL 339
Cdd:cd17449   241 PNGSRRKLALYSLALFVVVTVHFGAKDLLVLYELSSPLCWDSDLIGYGSAAEHLTYLSSLLGLRLLQLCLEDTWVAEIGL 320

                         330       340
                  ....*....|....*....|..
gi 2462552835 340 AFNILGMVVFAFATITPLMFTG 361
Cdd:cd17449   321 ISNISGLVVISVATTTPLMFTG 342
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
73-362 1.98e-10

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 61.91  E-value: 1.98e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462552835  73 PTMQEVETLTSHWTLYMNVGGFLVGLFSSTLLGAWSDSVGRRPLLVLASLGLLLQALVSVFVVqlqlHVGYFVLGRILCA 152
Cdd:COG2814    34 PLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAP----SLWLLLAARFLQG 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462552835 153 LLGdfGGLLAASFASVADVSSSRSRTFRMALLEASIGVAGMLASLLGGHWLRAQGYANPFWLALALLIAMTLYAAFCFGE 232
Cdd:COG2814   110 LGA--GALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLALLLLLRLLPE 187

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462552835 233 TLKEPKSTRLFTFRHHRsivqlyvapapekSRKHLALYSLAIFVVITVHFGAQDILTLYeLSTPLCWDSKLIGYGSAAQH 312
Cdd:COG2814   188 SRPAARARLRGSLRELL-------------RRPRLLLLLLLAFLLGFGFFALFTYLPLY-LQEVLGLSASAAGLLLALFG 253

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 2462552835 313 LPYLTSLLALKLLQYCLADAWVAEIGLAFNILGMVVFAFATITPLMFTGC 362
Cdd:COG2814   254 LGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLAL 303
MFS_1 pfam07690
Major Facilitator Superfamily;
94-291 5.01e-08

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 54.35  E-value: 5.01e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462552835  94 FLVGLFSSTLLGAWSDSVGRRPLLVLASLGlllqALVSVFVVQLQLHVGYFVLGRILCALLGdfGGLLAASFASVADVSS 173
Cdd:pfam07690  42 SLGYALAQPLAGRLSDRFGRRRVLLIGLLL----FALGLLLLLFASSLWLLLVLRVLQGLGA--GALFPAALALIADWFP 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462552835 174 SRSRTFRMALLEASIGVAGMLASLLGGHWLRAQGYANPFWLALALLIAMTLYAAFcfgeTLKEPKSTRlftFRHHRSIVQ 253
Cdd:pfam07690 116 PEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLL----PRPPPESKR---PKPAEEARL 188

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 2462552835 254 LYVAPAPEKSRKHLALYSLAIFVVITVHFGAQDILTLY 291
Cdd:pfam07690 189 SLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLY 226
 
Name Accession Description Interval E-value
MFS_SLC46A1_PCFT cd17449
Solute carrier family 46 member 1, also called Proton-coupled folate transporter, of the Major ...
 22-361 0e+00

Solute carrier family 46 member 1, also called Proton-coupled folate transporter, of the Major Facilitator Superfamily of transporters; Solute carrier family 46 member 1 (SLC46A1) is also called proton-coupled folate transporter (PCFT), G21, or heme carrier protein 1 (HCP1). It functions in two ways: as an intestinal proton-coupled high-affinity folate transporter that facilitates the absorption of folates across the brush-border membrane of the small intestine; and as an intestinal heme transporter which mediates heme uptake from the gut lumen into duodenal epithelial cells. It displays a higher affinity for folate than heme. It is also expressed in the choroid plexus and is required for transport of folates into the cerebrospinal fluid. Loss of function mutations in the SLC46A1 gene results in the autosomal recessive disorder "hereditary folate malabsorption" (HFM), characterized by severe systemic and cerebral folate deficiency. SLC46A1 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341007 [Multi-domain]  Cd Length: 425  Bit Score: 554.80  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462552835  22 RGPVEPLVFLANFALVLQGPLTTQYLWHRFSADLGYNGTRQRG--GCSNRSADPTMQEVETLTSHWTLYMNVGGFLVGLF 99
Cdd:cd17449     1 SVTVEPVLFLAMFALVLQGPLTTQYLWDRLSADLGYNGTRTRGcaSNASTSADPLQQEVETLTAHWNLYINLGGFLVGLF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462552835 100 SSTLLGAWSDSVGRRPLLVLASLGLLLQALVSVFVVQLQLHVGYFVLGRILCALLGDFGGLLAASFASVADVSSSRSRTF 179
Cdd:cd17449    81 SVTLLGPWSDSVGRRPVLILPSLGLALQAAVYLLVMYLQLHVAYFLIGRILSGLLGDFNGILAGCFAYVADVSDRRSRTF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462552835 180 RMALLEASIGVAGMLASLLGGHWLRAQGYANPFWLALALLIAMTLYAAFCFGETLKEPKSTRLFTFRHHRSIVQLYVAPA 259
Cdd:cd17449   161 RVAVLEACLGLAGMLASIIGGQWRKAQGYINPFWLVLALNLAAALYAAFCVGESVKEPKSARLFTTRHHQSVVRLYVAPA 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462552835 260 PEKSRKHLALYSLAIFVVITVHFGAQDILTLYELSTPLCWDSKLIGYGSAAQHLPYLTSLLALKLLQYCLADAWVAEIGL 339
Cdd:cd17449   241 PNGSRRKLALYSLALFVVVTVHFGAKDLLVLYELSSPLCWDSDLIGYGSAAEHLTYLSSLLGLRLLQLCLEDTWVAEIGL 320

                         330       340
                  ....*....|....*....|..
gi 2462552835 340 AFNILGMVVFAFATITPLMFTG 361
Cdd:cd17449   321 ISNISGLVVISVATTTPLMFTG 342
MFS_SLC46 cd17386
Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The ...
 22-362 1.03e-74

Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3) and similar proteins from insects and nematodes. The best-studied member is SLC46A1, also called proton-coupled folate transporter (PCFT), which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. SLC46A2, also called thymic stromal cotransporter protein (TSCOT), is a putative 12-transmembrane protein mainly expressed in the thymic cortex in a specific thymic epithelial cell (TEC) subpopulation. SLC46A3 is a lysosomal membrane protein that functions as a direct transporter of noncleavable antibody maytansine-based catabolites from the lysosome to the cytoplasm. The SLC46 family belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340944 [Multi-domain]  Cd Length: 360  Bit Score: 237.18  E-value: 1.03e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462552835  22 RGPVEPLVFLANFALVLQGPLTTQYlwhrfsadlgyngtrqrggcsnrsadptmqeveTLTSHWTLYMNVGGFLVGLFSS 101
Cdd:cd17386     1 MLNVEPIVFLYMFASVLSGPVTQNF---------------------------------VYAANFYLYMNLMGSIPPLFSS 47

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462552835 102 TLLGAWSDSVGRRPLLVLASLGLLLQALVSVFVVQL--QLHVGYFVLGRILCALLGDFGGLLAASFASVADVSSSRSRTF 179
Cdd:cd17386    48 LFLGSWSDRYGRKPPLLMSLVGLLLSSLILVLIVYFttVPSVWWFYLSAIPLALFGGFTAFLSASFAYISDISSEKKRTY 127

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462552835 180 RMALLEASIGVAGMLASLLGGHWLRAQGYANPFWLALALLIAMTLYAAFCFgetlkepkstrlftfrhhrsivqlyvapa 259
Cdd:cd17386   128 RMAILEVALGLGGFLGSLLSGHLFKALGYAWSFSISAALLLIALLYILFFL----------------------------- 178

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462552835 260 peksrKHLALYSLAIFVVITVHFGAQDILTLYELsTPLCWDSKLIGYGSAAQHLPYLTSLLALKLLQYCL---ADAWVAE 336
Cdd:cd17386   179 -----TLLILLLLAAFLTIFVLSGESDVLYLFVL-EKFAWNVKDFSYFSTLGSLIYLTGMLGGVLLLRCLlkmSDSTLAM 252

                         330       340
                  ....*....|....*....|....*.
gi 2462552835 337 IGLAFNILGMVVFAFATITPLMFTGC 362
Cdd:cd17386   253 LGLASHILSSLLFAFATNTWMMYLAA 278
MFS_SLC46A3 cd17448
Solute carrier family 46 member 3 of the Major Facilitator Superfamily of transporters; Solute ...
 25-359 2.13e-42

Solute carrier family 46 member 3 of the Major Facilitator Superfamily of transporters; Solute carrier family 46 member 3 (SLC46A3) is a lysosomal membrane protein that functions as a direct transporter of noncleavable antibody maytansine-based catabolites from the lysosome to the cytoplasm. SLC46A3 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341006  Cd Length: 396  Bit Score: 153.35  E-value: 2.13e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462552835  25 VEPLVFLANFALVLQGPLTTQY----LWHRFSADLGYNGTRQRGGCSNRSaDPTM---QEVETLTSHWTLYMNVGGFLVG 97
Cdd:cd17448     4 VEPVVALYAFASFMTYPLIQQYvyrrLWEETSNSTYISSSNISHCEKNKS-SPAFvfqEEVQKKTSLFNMQMDLSGLIPS 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462552835  98 LFSSTLLGAWSDSVGRRPLLVLASLGLLLQALVSVFVVQLQLHVGYFVLGRILCALLGDFGGLLAASFASVADVSS-SRS 176
Cdd:cd17448    83 LIVTLILVSYSDRHGRKFSIILPSIGALLTSLSYCLVSYFSFPLNLLIASSFISGLFGGFTTFIGGCFAYVADLCKdHKQ 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462552835 177 RTFRMALLEASIGVAGMLASLLGGHWLRAQGYANPFWLALALLIAMTLYAAFcfgetlkepkstrlftfrhhrsivqlyv 256
Cdd:cd17448   163 KTIRMAVVDMILGVLTGLAGLSSGYFIRALGFNWPFLTIALLHVVNLLYILF---------------------------- 214

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462552835 257 apapeksrkHLALYSLAIFVVIT---VHFGAQDILTLYELSTPLCWDSKLIGYGSAAQHLPYLTSLLALKLLQYCLADAW 333
Cdd:cd17448   215 ---------FLVVLCLLLFAFSTyllANFGGASIFILYELNAPLCWNEVLVGYGSAASTAIFLTSFVGVALFSRCLPDIY 285

                         330       340
                  ....*....|....*....|....*.
gi 2462552835 334 VAEIGLAFNILGMVVFAFATITPLMF 359
Cdd:cd17448   286 IVFIGIFSVAGGMIMTAFAKTTLLMF 311
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 93-361 9.03e-12

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 66.06  E-value: 9.03e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462552835  93 GFLVGLFSSTLLGAWSDSVGRRPLLVLASLGlllqALVSVFVVQLQLHVGYFVLGRILCALlgdFGGLLAASFASVADVS 172
Cdd:cd17330    43 YSLGQFLASPLWGRLSDRYGRKPVLLLSLAG----SAVSYVLLGLSRNLWLLFLARFLDGL---TGGNVSVAQAYIADIT 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462552835 173 SSRSRTFRMALLEASIGVAGMLASLLGGHWLRAQGYANPFWLALALLIAMTLYAAFCfgetlkepkstrLFTFRhhrsiv 252
Cdd:cd17330   116 DEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALALLNLVLVLFF------------LPPLR------ 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462552835 253 qlyvapapeksrkhlalYSLAIFVVITVHFGAQDILTLYELSTPLCWDSKLIGYGSAAQHLPYLTSLLALKLLQYC-LAD 331
Cdd:cd17330   178 -----------------RLLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVGIAGILAQLLLIPRLAKrLGE 240

                         250       260       270
                  ....*....|....*....|....*....|
gi 2462552835 332 AWVAEIGLAFNILGMVVFAFATITPLMFTG 361
Cdd:cd17330   241 RKLLRLGLLLAIIGLLLLPFASSVPLLVLA 270
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
73-362 1.98e-10

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 61.91  E-value: 1.98e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462552835  73 PTMQEVETLTSHWTLYMNVGGFLVGLFSSTLLGAWSDSVGRRPLLVLASLGLLLQALVSVFVVqlqlHVGYFVLGRILCA 152
Cdd:COG2814    34 PLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAP----SLWLLLAARFLQG 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462552835 153 LLGdfGGLLAASFASVADVSSSRSRTFRMALLEASIGVAGMLASLLGGHWLRAQGYANPFWLALALLIAMTLYAAFCFGE 232
Cdd:COG2814   110 LGA--GALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLALLLLLRLLPE 187

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462552835 233 TLKEPKSTRLFTFRHHRsivqlyvapapekSRKHLALYSLAIFVVITVHFGAQDILTLYeLSTPLCWDSKLIGYGSAAQH 312
Cdd:COG2814   188 SRPAARARLRGSLRELL-------------RRPRLLLLLLLAFLLGFGFFALFTYLPLY-LQEVLGLSASAAGLLLALFG 253

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 2462552835 313 LPYLTSLLALKLLQYCLADAWVAEIGLAFNILGMVVFAFATITPLMFTGC 362
Cdd:COG2814   254 LGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLAL 303
MFS_TetA cd17388
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ...
 101-359 1.62e-09

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340946 [Multi-domain]  Cd Length: 385  Bit Score: 59.19  E-value: 1.62e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462552835 101 STLLGAWSDSVGRRPLLVLASLGLLLQALVSVFVVQLqlhvGYFVLGRILcallgdfGGLLAASFAS----VADVSSSRS 176
Cdd:cd17388    55 APILGALSDRFGRRPVLLLSLAGAALDYLLMAFAPTL----WWLYLGRII-------AGITGATGAVaaayIADVTPPEQ 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462552835 177 RTFRMALLEASIG---VAG-MLASLLGGHWLRAqgyanPFWLALALLIAMTLYAAFCFGETLKePKSTRLFTFRHHRSIV 252
Cdd:cd17388   124 RARNFGLLGAAFGlgfIAGpALGGLLGEISPRA-----PFLVAAGLNGLNFLLGLFVLPESLP-PERRRAFRWRRANPFG 197

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462552835 253 QLYVApapeksRKHLALYSL-AIFVVITvhFGAQDILTLYELSTP--LCWDSKLIGYGSAAQHLPYLTS-LLALKLLQYC 328
Cdd:cd17388   198 SLRWL------TGFPGLLGLlAVFFLIQ--LIGQVPATTWVLFTEdrFDWSPTMVGLSLAVFGLLHALFqAFVTGPIAKR 269

                         250       260       270
                  ....*....|....*....|....*....|.
gi 2462552835 329 LADAWVAEIGLAFNILGMVVFAFATITPLMF 359
Cdd:cd17388   270 LGEKRAILLGLAADALGFLLLAFATQGWMVF 300
MFS_1 pfam07690
Major Facilitator Superfamily;
94-291 5.01e-08

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 54.35  E-value: 5.01e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462552835  94 FLVGLFSSTLLGAWSDSVGRRPLLVLASLGlllqALVSVFVVQLQLHVGYFVLGRILCALLGdfGGLLAASFASVADVSS 173
Cdd:pfam07690  42 SLGYALAQPLAGRLSDRFGRRRVLLIGLLL----FALGLLLLLFASSLWLLLVLRVLQGLGA--GALFPAALALIADWFP 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462552835 174 SRSRTFRMALLEASIGVAGMLASLLGGHWLRAQGYANPFWLALALLIAMTLYAAFcfgeTLKEPKSTRlftFRHHRSIVQ 253
Cdd:pfam07690 116 PEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLL----PRPPPESKR---PKPAEEARL 188

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 2462552835 254 LYVAPAPEKSRKHLALYSLAIFVVITVHFGAQDILTLY 291
Cdd:pfam07690 189 SLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLY 226
MFS_SLC46A2_TSCOT cd17450
Solute carrier family 46 member 2, also called Thymic stromal cotransporter protein, of the ...
 63-359 2.12e-07

Solute carrier family 46 member 2, also called Thymic stromal cotransporter protein, of the Major Facilitator Superfamily of transporters; Solute carrier family 46 member 2 (SLC46A2) is also called thymic stromal cotransporter protein (TSCOT). It is a putative 12-transmembrane protein mainly expressed in the thymic cortex in a specific thymic epithelial cell (TEC) subpopulation. Polymorphisms in TSCOT are linked to cervical cancer in affected sib-pairs with high mean age at diagnosis. TSCOT belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341008  Cd Length: 383  Bit Score: 52.45  E-value: 2.12e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462552835  63 RGGCSNRSADPTMQEvETLTSHWTLYMNVGGfLVGLFSSTLLGAWSDSVGRRPLLVLASLGLLLQALVSVFVVQLQLHVG 142
Cdd:cd17450    32 NTSSSSNRGLEDAQQ-KAISNFYMIYNLVAG-LSPLLPAYLLAKLGDRRHRKITICVPLLGYLLSRALLLLVILLDWPLE 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462552835 143 YFVLGRILCALLGDFGGLLAASFASVADVSSSRSRTFRMALLEASIGVAGMLASLLGGHWLRAqgYANPFWLALALLIAM 222
Cdd:cd17450   110 VMYGAAALNGLTGGFTAYWAGVMALASLASSEGRRSVRLITIELVYGLAGFLGSLASGHIFVH--YTINHHQGAILAACS 187

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462552835 223 TLYAAFCFGETLkepkstrlFTFRHhrSIVQLYVApapeksrkhLALYSLAIFvvitvhfGAQDILTLYELSTPLCWDSK 302
Cdd:cd17450   188 LVLYVLCLLYSV--------FVLKI--TIALLFVG---------AILYDLAVA-------GGMDVLSVFVLKEPLSWGAV 241

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462552835 303 LIGYGSAAQHLPYLTSLLALKLLQYCLADAWVAEIGLAFNILGMVVFAFATITPLMF 359
Cdd:cd17450   242 EVGYGNAAGYMIFITSFLGVFVFSRCLRDTTMIMIGMVSFSSGILIMAFVKWTFMFY 298
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 82-243 5.66e-07

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 51.04  E-value: 5.66e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462552835  82 TSHWTLYMNVGGFLVGLFsstLLGAWSDSVGRRPLlvlaslglllqALVSVFVvqlqlhvgyFVLGRILCALLGDFGGLL 161
Cdd:cd17320    35 AVQLTLSAYLLGFALGQL---LYGPLSDRFGRRPV-----------LLAGLLL---------FILASLLCALASSIEQLL 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462552835 162 AASF--------------ASVADVSSSRSRTFRMALLEASIGVAGMLASLLGGHWLRAQGYANPFWLALALLIAMTLYAA 227
Cdd:cd17320    92 IARFlqglgaaagsvvarAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLLLLLVL 171

                         170
                  ....*....|....*.
gi 2462552835 228 FCFGETLKEPKSTRLF 243
Cdd:cd17320   172 LFLPETLPEEKRKPLL 187
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 73-363 1.52e-06

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 49.73  E-value: 1.52e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462552835  73 PTMQEVETLTSHWTLYMNVGGFLVGLFSSTLLGAWSDSVGRRPLLVLASLGLLLQALVSVFVVQLQLhvgyFVLGRILCA 152
Cdd:cd06174    20 PALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWL----LLLGRFLLG 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462552835 153 LLgdFGGLLAASFASVADVSSSRSRTFRMALLEASIGVAGMLASLLGGHWLRA--QGYANPFWLALALLIAMTLYAAFCF 230
Cdd:cd06174    96 LG--SGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSlgFGWRAVFLIAAALALLAAILLLLVV 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462552835 231 gETLKEPKSTRLFTFRHHRSIVQLYVApapeKSRKHLALYSLAIFVVITVHFGAQDILTLYeLSTPLCWDSKLIGYGSAA 310
Cdd:cd06174   174 -PDPPESARAKNEEASSKSVLKLLKRV----LKNPGLWLLLLAIFLVNLAYYSFSTLLPLF-LLDLGGLSVAVAGLLLSL 247

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2462552835 311 QHLPYLTSLLALKL-LQYCLADAWVAEIGLAFNILGMVVFAFATITPLMFTGCW 363
Cdd:cd06174   248 FGLAGALGSLLLGLlSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLL 301
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 75-228 1.67e-06

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 49.88  E-value: 1.67e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462552835  75 MQEVETLTSHWTLYMNVGGFLVGLFSSTLLGAWSDSVGRRPLLVLASLGLLlqalVSVFVVQLQLHVGYFVLGRILCALL 154
Cdd:cd17325   226 AAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSA----VALLLLPLATSFWLLLLLLALLGLG 301

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462552835 155 gdFGGLLAASFASVADVSSSRSRTFRMALLEASIGVAGMLASLLGGHWLRAQGYANPFWLALALLIAMTLYAAF 228
Cdd:cd17325   302 --LGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLL 373
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 93-359 3.36e-06

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 48.73  E-value: 3.36e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462552835  93 GFLVGLFSSTLL------GAWSDSVGRRPLLVLASLGLLLQALVSVFVVqlqlHVGYFVLGRILCALLGdfGGLLAASFA 166
Cdd:cd17325    34 GLIVAAYALAQLlfsppaGRLSDRFGRKRLLLLGLLLLAVSTLLFAFAT----SYWQLLLARFLQGLAS--AAVWPAAMA 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462552835 167 SVADVSSSRSRTFRMALLEASIGVAGMLASLLGGHWLRAQGYANPFWLALALLIAMTLYAAFCFGETLKEPKSTRLFTFR 246
Cdd:cd17325   108 LIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPEPRPPPNKRAVSAAR 187

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462552835 247 HHRSIVQLyvapapeKSRKHLALYSLAIFVVITVHFGAQDILTLYeLSTPLCWDSKLIGYGSAAQHLPYLTSLLALKLlq 326
Cdd:cd17325   188 LRSGLRLL-------LRDRRLLALFLAIFVLAFAFGALEPFLPLY-AAELGGLSPAQIGLLFGAQGLASALSQPPAGK-- 257

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 2462552835 327 ycLADAW----VAEIGLAFNILGMVVFAFATITPLMF 359
Cdd:cd17325   258 --LSDRIgrkpLILIGLLLSAVALLLLPLATSFWLLL 292
MFS_MFSD9 cd17390
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...
 98-232 4.42e-06

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340948 [Multi-domain]  Cd Length: 350  Bit Score: 48.38  E-value: 4.42e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462552835  98 LFSSTLLGAWSDSVGRRPllvlaslglllqalvSVFVVQLQLHVGYFVLGRI----LCAL----LGDFGGLLAASFASVA 169
Cdd:cd17390    45 LFSSPLVGSWSDVVGRRP---------------VLLICLLLTALGYVLLGFStslaLLFLsripLGIFKHTQSLCKAYLS 109

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462552835 170 DVSSSRSRTFRMALLEASIGVAGMLASLLGGHWLRAQ-GYANPFWLALALLIAMTLYAAFCFGE 232
Cdd:cd17390   110 DLVSEQERSRVLGRFNAASSLGFILGPVVGGHLAETDgGFYYVALLCSAIFILNAGLVWFLLSK 173
MFS_MFSD10 cd17389
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ...
 92-234 1.17e-05

Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340947 [Multi-domain]  Cd Length: 391  Bit Score: 47.27  E-value: 1.17e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462552835  92 GGFLVGLFS------STLLGAWSDSVGRRPLLVLASLGLLLQALVSVFVVQLQLhvgyFVLGRILCALLgdfGGLLAASF 165
Cdd:cd17389    66 GGLIGSLFSllqflsSPITGAASDVYGRKPVLLLTMIGLAISYALWAVSRSFTI----FLLSRIVGGIS---KGNVSLST 138

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462552835 166 ASVADVSSSRSRTFRMALleasIGVAGMLASLLG---GHWLRAQG-------YANPFWLALALLIAMTLYAAFCFGETL 234
Cdd:cd17389   139 AIVADVTSPKKRSKGMAL----IGVAFSLGFIIGpmiGAYFASFTrslgevfFSMPALFALVLALADLLFIFFFLPETL 213
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 90-252 2.96e-04

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 42.58  E-value: 2.96e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462552835  90 NVGGFLVGLFS-STLL-----GAWSDSVGRRPLLVLASLGLLLQALVSVFVVQLQLhvgyFVLGRILCALlgDFGGLLAA 163
Cdd:cd17489    31 AVAGLVVGLFTlAALLarpfaGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVAL----LLVLRLIHGI--GWGAFTTA 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462552835 164 SFASVADVSSSRSRTFRMALLEASIGVAGMLASLLGGHWLRAQGYANPFWLALALLIAMTLYAAFCFGETLKEPKSTRLF 243
Cdd:cd17489   105 AATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLVFLVKDPPPVAAEEAEAG 184


                  ....*....
gi 2462552835 244 TFRHHRSIV 252
Cdd:cd17489   185 TRAFRRLVE 193
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
94-235 5.22e-04

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 41.78  E-value: 5.22e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462552835  94 FLVGLFSSTLLGAWSDSVGRRPLLVLASLGLLlqALVSVFVVQLQLHVGYFVLgrILCALLGDFGGLLAASFASVADVSS 173
Cdd:COG2271   226 FLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLL--AALALLLLALLPSPALAIA--LLFLAGFGLGGAFGLLWALAAELFP 301

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462552835 174 SRSRTFRMALLEASIGVAGMLASLLGGHWLRAQGYANPFWLALALLIAMTLYAAFCFGETLK 235
Cdd:COG2271   302 KKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRETRK 363
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 89-233 7.61e-04

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 41.44  E-value: 7.61e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462552835  89 MNVGGFLVGLFSstllGAWSDSVGRRPLLVLASLGLLLQALVSVFVVQLQLHVgyfvlgrILCALLGDFGGLL-AASFAS 167
Cdd:cd17329    44 SAVAGIVASLIG----GRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFA-------IALVLTGFGGGLFePASEAM 112

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462552835 168 VADVSSSRSRTFRMALLEASIGVAGMLASLLGGhWLRAQGYANPFWLALALLIAMTLYAAFCFGET 233
Cdd:cd17329   113 IADVTTPENRTRAFSLLYWAINLGVAIGPLLGG-LLLLYSFRLLFLAAAVLFLLAALVLLFLLPET 177
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 71-228 8.32e-04

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 40.95  E-value: 8.32e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462552835  71 ADPTMQEVETLTSHWTLYMNVGGFLVGLFSSTLLGAWSDSVGRRPLLVLASLGLLLQALVSVFVVQLQLhvgyFVLGRIL 150
Cdd:COG0477    36 ALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPSPEL----LIAARAL 111

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462552835 151 CALLGdfGGLLAASFASVADVSSSRSRTFRMALLEASIGVAGMLASLLGGHWLRAQGYANPFWLALALLIAMTLYAAF 228
Cdd:COG0477   112 QGIGA--GGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAPLGLLALVLRLR 187
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
88-230 1.13e-03

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 41.02  E-value: 1.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462552835  88 YMNVGGFLVGLFSSTLLGAWSDSVGRRPllvLASLGLLLQALVSVFVVQLQLHVGYFVLGRILCALLgdFGGLLAASFAS 167
Cdd:COG2223   245 LLAALFALLGALGRPLGGWLSDRIGGRR---VLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLA--LGGGNGAVFAL 319

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462552835 168 VADVSSSRSRTFRMALLEASIGVAGMLASLLGGHWLRAQG-YANPFWLALALLIAMTLYAAFCF 230
Cdd:COG2223   320 VPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGsYTAAFLVFAVLALVALVLTLLLY 383
MFS_Set cd17471
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ...
 95-297 1.36e-03

Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341024 [Multi-domain]  Cd Length: 371  Bit Score: 40.61  E-value: 1.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462552835  95 LVGLFSSTLLGAWSDS-VGRRPLLVLASLGLLLQALVSVFVVQlqlhvgYFVLGRILCALLGDFGGLLAASFA---SVAD 170
Cdd:cd17471    43 LSGIVVSQWLGRLSDRgGDRKPLILLALLAGALGYLLFAFLRN------YWVLLLVGVVLLSLGAAAFPQLFAlarEYAD 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462552835 171 VSSSRSRTFRMALLEASIGVAGMLASLLGGHWLRAQGYANPFWLALALLIAMTLYAAFcfgetlkepkstRLFTFRHHRS 250
Cdd:cd17471   117 RSSGRDATLFNSVLRAAFSLAWVIGPPLAFLLLDVLGFTGLFLLAALLYLVVALLVLF------------LLPSVKPPAQ 184

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 2462552835 251 IVQLYVAPAPEKSRKHLALYSLAIFVVITVHFgaqdiltLYELSTPL 297
Cdd:cd17471   185 KATPASSLVKAPVNRRLLLLFAAFTLLFAANS-------MYIIAMPL 224
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
144-291 1.59e-03

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 40.61  E-value: 1.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462552835 144 FVLGRILCALLGDFGGLLAASF-----ASVADVSS--------SRSRTFRMALLEASIGVAGMLASLLGGHWLRAQ---G 207
Cdd:COG0738    83 MALGLLLFALAPSYPLLLLALFllglgLGLLDVAAnpyvaalgPETAASRLNLLHAFFSLGALLGPLLGGLLILLGlslS 162

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462552835 208 YANPFWLALALLIAMTLYAAFCFGETLKEPKSTRLFTFRHHRSIVQlyvapapeksRKHLALYSLAIFVVITVHFGAQDI 287
Cdd:COG0738   163 WHLPYLILAVLLLLLALLFLRSKLPEIEEEEEEAAGSAASLKSLLK----------NPRLLLGGLAIFLYVGAEGAIGDW 232


                  ....
gi 2462552835 288 LTLY 291
Cdd:COG0738   233 LPLY 236
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
94-291 1.68e-03

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 40.25  E-value: 1.68e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462552835  94 FLVGLFSSTLLGAWSDSVGRRPLLVLASLGLLLQALVSVFVVQLQLhvgyFVLGRILCALLGdfGGLLAASFASVADVSS 173
Cdd:COG2223    50 VLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWL----LLLLGLLLGIGG--GGSFAVGIALVSKWFP 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462552835 174 SRSRTFRMALLEASIGVAGMLASLLGGHWLRAQGYANPFWLALALLIAMTLYAAFCFGETLKEPKSTRLFTFRHHRSIVq 253
Cdd:COG2223   124 PDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVAVLAWLFLRDPPAGAAAAAKASLRDQLEAL- 202

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 2462552835 254 lyvapapekSRKHLALYSLAIFVVITVHFGAQDILTLY 291
Cdd:COG2223   203 ---------RDPRFWLLSLLYFGTFGSFIGFSSWLPPY 231
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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