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Conserved domains on  [gi|2462554724|ref|XP_054171827|]
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COP9 signalosome complex subunit 1 isoform X17 [Homo sapiens]

Protein Classification

COP9 signalosome complex subunit 1( domain architecture ID 10566214)

The COP9 signalosome subunit 1 (CSN1) is an essential component of the CSN complex and is involved in the deubiquitination of target proteins which helps to regulate the stability and activity of a variety of proteins involved in different cellular pathways

Gene Ontology:  GO:0000338|GO:0008180|GO:2000434
PubMed:  27029275|9644972
SCOP:  4000147

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
RPN7 pfam10602
26S proteasome subunit RPN7; RPN7 (known as the non ATPase regulatory subunit 6 in higher ...
190-372 6.89e-68

26S proteasome subunit RPN7; RPN7 (known as the non ATPase regulatory subunit 6 in higher eukaryotes) is one of the lid subunits of the 26S proteasome and has been shown in Saccharomyces cerevisiae to be required for structural integrity. The 26S proteasome is is involved in the ATP-dependent degradation of ubiquitinated proteins.


:

Pssm-ID: 431387  Cd Length: 174  Bit Score: 217.06  E-value: 6.89e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462554724 190 DTAWVEATRKKALLKLEKLDTDLKNYKGNSIKESIRRGHDDLGDHYLDCGDLSNALKCYSRARDYCTSAKHVINMCLNVI 269
Cdd:pfam10602   1 DEAWVEELKKKNEKELEELDAELKDAKENLGKEEIRMANLDLAEHYAKIGDLENALKAYERAREYCTSLGHKIDMCLNLI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462554724 270 KVSVYLQNWSHVLSYVSKAESTPEIAEQrgerdsqtQAILTKLKCAAGLAELAARKYKQAAKCLLLASFDHCDfPELLSP 349
Cdd:pfam10602  81 RVGIFFNDWDLVSKYIEKAKSLIEKGGD--------WERRNRLKVYEGLALLAIRDFKEAAKLFLDSLSTFTS-TELISY 151
                         170       180
                  ....*....|....*....|...
gi 2462554724 350 SNVAIYGGLCALATFDRQELQRN 372
Cdd:pfam10602 152 EDVAVYGVLCALASLDRVDLKAK 174
PCI pfam01399
PCI domain; This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and ...
387-491 4.78e-23

PCI domain; This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and TRIP-15).


:

Pssm-ID: 460195  Cd Length: 105  Bit Score: 93.82  E-value: 4.78e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462554724 387 PQVRDIIFKFYESKYASCLKMLDEMKDNLLLDMYLAPHVRTLYTQIRNRALIQYFSPYVSADMHRMAAAFNTTVAALEDE 466
Cdd:pfam01399   1 PAYRDLLRAFYSGDLSEFEEILADYKEELLLDDGLAEHLEDLRRKIREHNLRQLSKPYSSISLSDLAKLLGLSVDEVEKI 80
                          90       100
                  ....*....|....*....|....*
gi 2462554724 467 LTQLILEGLISARVDSHSKILYARD 491
Cdd:pfam01399  81 LAKLIRDGRIRAKIDQVNGIVVFSK 105
 
Name Accession Description Interval E-value
RPN7 pfam10602
26S proteasome subunit RPN7; RPN7 (known as the non ATPase regulatory subunit 6 in higher ...
190-372 6.89e-68

26S proteasome subunit RPN7; RPN7 (known as the non ATPase regulatory subunit 6 in higher eukaryotes) is one of the lid subunits of the 26S proteasome and has been shown in Saccharomyces cerevisiae to be required for structural integrity. The 26S proteasome is is involved in the ATP-dependent degradation of ubiquitinated proteins.


Pssm-ID: 431387  Cd Length: 174  Bit Score: 217.06  E-value: 6.89e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462554724 190 DTAWVEATRKKALLKLEKLDTDLKNYKGNSIKESIRRGHDDLGDHYLDCGDLSNALKCYSRARDYCTSAKHVINMCLNVI 269
Cdd:pfam10602   1 DEAWVEELKKKNEKELEELDAELKDAKENLGKEEIRMANLDLAEHYAKIGDLENALKAYERAREYCTSLGHKIDMCLNLI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462554724 270 KVSVYLQNWSHVLSYVSKAESTPEIAEQrgerdsqtQAILTKLKCAAGLAELAARKYKQAAKCLLLASFDHCDfPELLSP 349
Cdd:pfam10602  81 RVGIFFNDWDLVSKYIEKAKSLIEKGGD--------WERRNRLKVYEGLALLAIRDFKEAAKLFLDSLSTFTS-TELISY 151
                         170       180
                  ....*....|....*....|...
gi 2462554724 350 SNVAIYGGLCALATFDRQELQRN 372
Cdd:pfam10602 152 EDVAVYGVLCALASLDRVDLKAK 174
PCI pfam01399
PCI domain; This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and ...
387-491 4.78e-23

PCI domain; This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and TRIP-15).


Pssm-ID: 460195  Cd Length: 105  Bit Score: 93.82  E-value: 4.78e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462554724 387 PQVRDIIFKFYESKYASCLKMLDEMKDNLLLDMYLAPHVRTLYTQIRNRALIQYFSPYVSADMHRMAAAFNTTVAALEDE 466
Cdd:pfam01399   1 PAYRDLLRAFYSGDLSEFEEILADYKEELLLDDGLAEHLEDLRRKIREHNLRQLSKPYSSISLSDLAKLLGLSVDEVEKI 80
                          90       100
                  ....*....|....*....|....*
gi 2462554724 467 LTQLILEGLISARVDSHSKILYARD 491
Cdd:pfam01399  81 LAKLIRDGRIRAKIDQVNGIVVFSK 105
RPN7 COG5187
26S proteasome regulatory complex component, contains PCI domain [Posttranslational ...
230-529 2.96e-18

26S proteasome regulatory complex component, contains PCI domain [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227514 [Multi-domain]  Cd Length: 412  Bit Score: 87.28  E-value: 2.96e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462554724 230 DLGDHYLDCGDLSNALKCYSRA--RDYCTSAKhvINMCLNVIKVSVYLQNWSHVLSYVSKAEStpeIAEQRGERDSQTqa 307
Cdd:COG5187   120 NIAEYYCQIMDIQNGFEWMRRLmrDAMSTGLK--IDVFLCKIRLGLIYGDRKVVEESLEVADD---IIEKGGDWERRN-- 192
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462554724 308 iltKLKCAAGLAELAARKYKQAAKCLL--LASFDHCdfpELLSPSNVAIYGGLCALATFDRQELQRNVISSSSFklfLEL 385
Cdd:COG5187   193 ---RYKVYKGIFKMMRRNFKEAAILLSdiLPTFESS---ELISYSRAVRYAIFCGLLRLERRDIKTKILDSPEV---LDV 263
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462554724 386 EPQ------VRDIIFKFYESKYASCLKMLDEMKDNLLL-DMYLAPHVRTLYTQIRNRALIQYFSPYVSADMHRMAAAFNT 458
Cdd:COG5187   264 IGSseklgsLVQLATSLYECDYGGDFMNLLYLFCNSLQdDVFLGRHVDLFVREMRRRVYAQLLESYRLLSLESMAQTFGV 343
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462554724 459 TVAALEDELTQLILEGLISARVDSHSKILYARDVDQRSTTFEKSLLMGKEFQRRAKAMMlrAAVLRNQIHV 529
Cdd:COG5187   344 SVEYVDRDLGEFIPEGRLNCVIDRVNGVVETNRPDEKNQQYSSVVKQGDDLLRKLQKYV--ATVMRGAFKV 412
PINT smart00088
motif in proteasome subunits, Int-6, Nip-1 and TRIP-15; Also called the PCI (Proteasome, COP9, ...
423-506 4.19e-16

motif in proteasome subunits, Int-6, Nip-1 and TRIP-15; Also called the PCI (Proteasome, COP9, Initiation factor 3) domain. Unknown function.


Pssm-ID: 214509 [Multi-domain]  Cd Length: 88  Bit Score: 73.43  E-value: 4.19e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462554724  423 PHVRTLYTQIRNRALIQYFSPYVSADMHRMAAAFNTTVAALEDELTQLILEGLISARVDSHSKILYARDVDQRS----TT 498
Cdd:smart00088   1 QLVERLQRKIRLTNLLQLSEPYSSISLSDLAKLLGLSVPEVEKLVSKAIRDGEISAKIDQVNGIVEFEEVDPRRseplAQ 80

                   ....*...
gi 2462554724  499 FEKSLLMG 506
Cdd:smart00088  81 FAETLKKL 88
 
Name Accession Description Interval E-value
RPN7 pfam10602
26S proteasome subunit RPN7; RPN7 (known as the non ATPase regulatory subunit 6 in higher ...
190-372 6.89e-68

26S proteasome subunit RPN7; RPN7 (known as the non ATPase regulatory subunit 6 in higher eukaryotes) is one of the lid subunits of the 26S proteasome and has been shown in Saccharomyces cerevisiae to be required for structural integrity. The 26S proteasome is is involved in the ATP-dependent degradation of ubiquitinated proteins.


Pssm-ID: 431387  Cd Length: 174  Bit Score: 217.06  E-value: 6.89e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462554724 190 DTAWVEATRKKALLKLEKLDTDLKNYKGNSIKESIRRGHDDLGDHYLDCGDLSNALKCYSRARDYCTSAKHVINMCLNVI 269
Cdd:pfam10602   1 DEAWVEELKKKNEKELEELDAELKDAKENLGKEEIRMANLDLAEHYAKIGDLENALKAYERAREYCTSLGHKIDMCLNLI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462554724 270 KVSVYLQNWSHVLSYVSKAESTPEIAEQrgerdsqtQAILTKLKCAAGLAELAARKYKQAAKCLLLASFDHCDfPELLSP 349
Cdd:pfam10602  81 RVGIFFNDWDLVSKYIEKAKSLIEKGGD--------WERRNRLKVYEGLALLAIRDFKEAAKLFLDSLSTFTS-TELISY 151
                         170       180
                  ....*....|....*....|...
gi 2462554724 350 SNVAIYGGLCALATFDRQELQRN 372
Cdd:pfam10602 152 EDVAVYGVLCALASLDRVDLKAK 174
PCI pfam01399
PCI domain; This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and ...
387-491 4.78e-23

PCI domain; This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and TRIP-15).


Pssm-ID: 460195  Cd Length: 105  Bit Score: 93.82  E-value: 4.78e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462554724 387 PQVRDIIFKFYESKYASCLKMLDEMKDNLLLDMYLAPHVRTLYTQIRNRALIQYFSPYVSADMHRMAAAFNTTVAALEDE 466
Cdd:pfam01399   1 PAYRDLLRAFYSGDLSEFEEILADYKEELLLDDGLAEHLEDLRRKIREHNLRQLSKPYSSISLSDLAKLLGLSVDEVEKI 80
                          90       100
                  ....*....|....*....|....*
gi 2462554724 467 LTQLILEGLISARVDSHSKILYARD 491
Cdd:pfam01399  81 LAKLIRDGRIRAKIDQVNGIVVFSK 105
RPN7 COG5187
26S proteasome regulatory complex component, contains PCI domain [Posttranslational ...
230-529 2.96e-18

26S proteasome regulatory complex component, contains PCI domain [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227514 [Multi-domain]  Cd Length: 412  Bit Score: 87.28  E-value: 2.96e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462554724 230 DLGDHYLDCGDLSNALKCYSRA--RDYCTSAKhvINMCLNVIKVSVYLQNWSHVLSYVSKAEStpeIAEQRGERDSQTqa 307
Cdd:COG5187   120 NIAEYYCQIMDIQNGFEWMRRLmrDAMSTGLK--IDVFLCKIRLGLIYGDRKVVEESLEVADD---IIEKGGDWERRN-- 192
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462554724 308 iltKLKCAAGLAELAARKYKQAAKCLL--LASFDHCdfpELLSPSNVAIYGGLCALATFDRQELQRNVISSSSFklfLEL 385
Cdd:COG5187   193 ---RYKVYKGIFKMMRRNFKEAAILLSdiLPTFESS---ELISYSRAVRYAIFCGLLRLERRDIKTKILDSPEV---LDV 263
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462554724 386 EPQ------VRDIIFKFYESKYASCLKMLDEMKDNLLL-DMYLAPHVRTLYTQIRNRALIQYFSPYVSADMHRMAAAFNT 458
Cdd:COG5187   264 IGSseklgsLVQLATSLYECDYGGDFMNLLYLFCNSLQdDVFLGRHVDLFVREMRRRVYAQLLESYRLLSLESMAQTFGV 343
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462554724 459 TVAALEDELTQLILEGLISARVDSHSKILYARDVDQRSTTFEKSLLMGKEFQRRAKAMMlrAAVLRNQIHV 529
Cdd:COG5187   344 SVEYVDRDLGEFIPEGRLNCVIDRVNGVVETNRPDEKNQQYSSVVKQGDDLLRKLQKYV--ATVMRGAFKV 412
PINT smart00088
motif in proteasome subunits, Int-6, Nip-1 and TRIP-15; Also called the PCI (Proteasome, COP9, ...
423-506 4.19e-16

motif in proteasome subunits, Int-6, Nip-1 and TRIP-15; Also called the PCI (Proteasome, COP9, Initiation factor 3) domain. Unknown function.


Pssm-ID: 214509 [Multi-domain]  Cd Length: 88  Bit Score: 73.43  E-value: 4.19e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462554724  423 PHVRTLYTQIRNRALIQYFSPYVSADMHRMAAAFNTTVAALEDELTQLILEGLISARVDSHSKILYARDVDQRS----TT 498
Cdd:smart00088   1 QLVERLQRKIRLTNLLQLSEPYSSISLSDLAKLLGLSVPEVEKLVSKAIRDGEISAKIDQVNGIVEFEEVDPRRseplAQ 80

                   ....*...
gi 2462554724  499 FEKSLLMG 506
Cdd:smart00088  81 FAETLKKL 88
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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