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Conserved domains on  [gi|2462554939|ref|XP_054171933|]
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integrin alpha-3 isoform X1 [Homo sapiens]

Protein Classification

integrin alpha( domain architecture ID 12192630)

integrin alpha forms a heterodimer with integrin beta to mediate cell-extracellular matrix and cell-cell interactions; integrin alpha is a component of integrin, a cell adhesion molecule that mediates cell-extracellular matrix and cell-cell interactions

CATH:  2.130.10.130|2.60.40.1510|2.60.40.1530|2.60.40.1460
Gene Ontology:  GO:0007155|GO:0008305|GO:0005178|GO:0046872
PubMed:  3028640|2199285|12297042|12826403|14689578|12361595|12234368
SCOP:  4003137

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
Integrin_alpha2 pfam08441
Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C ...
 328-781 7.85e-115

Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of pfam01839 repeats and to the N-terminus of the pfam00357 cytoplasmic region. This region is composed of three immunoglobulin-like domains.


:

Pssm-ID: 462478 [Multi-domain]  Cd Length: 449  Bit Score: 358.94  E-value: 7.85e-115
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462554939 328 RPVINIVhKTLVPRPAVLDPA--LCTAT----SCVQVELCFAYNqsaGNPNYRRNITLAYTLEADRDRRPPRLR----FA 397
Cdd:pfam08441   1 RPVVSVS-ASLQVEPNSINPEkkNCTLTgtpvSCFTVRACFSYT---GKPIPNPSLVLNYELELDRQKKKGLPPrvlfLD 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462554939 398 GSESAVFHGFFSMPEMR--CQKLELLLMDNLRDKLRPIIISMNYSLplRMPDRPRLGLRSLDayPILNQAQALENHTEVQ 475
Cdd:pfam08441  77 SQQPSLTGTLVLLSQGRkvCRTTKAYLRDEFRDKLSPIVISLNYSL--RVDPRAPSDLPGLK--PILDQNQPSTVQEQAN 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462554939 476 FQKECGPDNKCESNLQMRAAFVSEQQQKLSRLQysrDVRKLLLSINVTNTrtsersGEDAHEALLTLVVPPALLLSSVRP 555
Cdd:pfam08441 153 FLKDCGEDNVCVPDLQLSAKFDSRESDEPLLLG---DDNDLALEITVTNL------GEDAYEAELYVTLPPGLDYSGVRR 223

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462554939 556 PGA-----CQANE-----TIFCELGNPFKRNQRMELLIAFEVIGVTLHTRDLQVQLQLSTSSHQD-NLWPMILTLLVDYT 624
Cdd:pfam08441 224 EGSekqlsCTAKKenstrQVVCDLGNPMKRGTQVTFGLRFSVSGLELSTEELSFDLQIRSTNEQNsNSNPVSLKVPVVAE 303

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462554939 625 LQTSLSMVNHRLQsFFGGTVMGESGMK--TVEDVGSPLKYEFQVGPMGEGLVglGTLVLGLEWPYEVSNGKWLLYPTEIT 702
Cdd:pfam08441 304 AQLSLSGVSKPDQ-VVGGSVKGESAMKprSEEDIGPLVEHTYEVINNGPSTV--SGASLEISWPYELSNGKWLLYLLDVQ 380

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462554939 703 VHGNGSwpCRPPgDLINPLNLTLSDPGDRPSSPQRRRRQLDPGGGQGPPPvtlaaaKKAKSETVLTCATGrAHCVWLEC 781
Cdd:pfam08441 381 GQGKGE--CSPQ-NEINPLNLTQSLESSKPLRTSRVHHVVKRRDVLKSEK------ATQTASVLLSCDSG-ARCVVIRC 449
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 48-108 1.04e-07

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


:

Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 49.30  E-value: 1.04e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462554939   48 PGSLFGYSVALHRQTERQQRYLLLAGAPRelavpDGFTNRTGAVYLCPLTAHKDDCERMNI 108
Cdd:smart00191   1 PGSYFGYSVAGVGDVNGDGYPDLLVGAPR-----ANDAGETGAVYVYFGSSGGGNSIPLQN 56
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 295-346 2.13e-03

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


:

Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 36.97  E-value: 2.13e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2462554939  295 FGYSLSGQMDVDENFYPDLLVGS-LSDHIVLLRARPVINIVHKTLVPRPAVLD 346
Cdd:smart00191   5 FGYSVAGVGDVNGDGYPDLLVGApRANDAGETGAVYVYFGSSGGGNSIPLQNL 57
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 246-282 2.67e-03

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


:

Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 36.97  E-value: 2.67e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 2462554939  246 GNLYIDIAVGAPFEG----LGKVYIYHSSSKGLLRQPQQVI 282
Cdd:smart00191  17 GDGYPDLLVGAPRANdageTGAVYVYFGSSGGGNSIPLQNL 57
 
Name Accession Description Interval E-value
Integrin_alpha2 pfam08441
Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C ...
 328-781 7.85e-115

Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of pfam01839 repeats and to the N-terminus of the pfam00357 cytoplasmic region. This region is composed of three immunoglobulin-like domains.


Pssm-ID: 462478 [Multi-domain]  Cd Length: 449  Bit Score: 358.94  E-value: 7.85e-115
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462554939 328 RPVINIVhKTLVPRPAVLDPA--LCTAT----SCVQVELCFAYNqsaGNPNYRRNITLAYTLEADRDRRPPRLR----FA 397
Cdd:pfam08441   1 RPVVSVS-ASLQVEPNSINPEkkNCTLTgtpvSCFTVRACFSYT---GKPIPNPSLVLNYELELDRQKKKGLPPrvlfLD 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462554939 398 GSESAVFHGFFSMPEMR--CQKLELLLMDNLRDKLRPIIISMNYSLplRMPDRPRLGLRSLDayPILNQAQALENHTEVQ 475
Cdd:pfam08441  77 SQQPSLTGTLVLLSQGRkvCRTTKAYLRDEFRDKLSPIVISLNYSL--RVDPRAPSDLPGLK--PILDQNQPSTVQEQAN 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462554939 476 FQKECGPDNKCESNLQMRAAFVSEQQQKLSRLQysrDVRKLLLSINVTNTrtsersGEDAHEALLTLVVPPALLLSSVRP 555
Cdd:pfam08441 153 FLKDCGEDNVCVPDLQLSAKFDSRESDEPLLLG---DDNDLALEITVTNL------GEDAYEAELYVTLPPGLDYSGVRR 223

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462554939 556 PGA-----CQANE-----TIFCELGNPFKRNQRMELLIAFEVIGVTLHTRDLQVQLQLSTSSHQD-NLWPMILTLLVDYT 624
Cdd:pfam08441 224 EGSekqlsCTAKKenstrQVVCDLGNPMKRGTQVTFGLRFSVSGLELSTEELSFDLQIRSTNEQNsNSNPVSLKVPVVAE 303

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462554939 625 LQTSLSMVNHRLQsFFGGTVMGESGMK--TVEDVGSPLKYEFQVGPMGEGLVglGTLVLGLEWPYEVSNGKWLLYPTEIT 702
Cdd:pfam08441 304 AQLSLSGVSKPDQ-VVGGSVKGESAMKprSEEDIGPLVEHTYEVINNGPSTV--SGASLEISWPYELSNGKWLLYLLDVQ 380

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462554939 703 VHGNGSwpCRPPgDLINPLNLTLSDPGDRPSSPQRRRRQLDPGGGQGPPPvtlaaaKKAKSETVLTCATGrAHCVWLEC 781
Cdd:pfam08441 381 GQGKGE--CSPQ-NEINPLNLTQSLESSKPLRTSRVHHVVKRRDVLKSEK------ATQTASVLLSCDSG-ARCVVIRC 449
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 48-108 1.04e-07

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 49.30  E-value: 1.04e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462554939   48 PGSLFGYSVALHRQTERQQRYLLLAGAPRelavpDGFTNRTGAVYLCPLTAHKDDCERMNI 108
Cdd:smart00191   1 PGSYFGYSVAGVGDVNGDGYPDLLVGAPR-----ANDAGETGAVYVYFGSSGGGNSIPLQN 56
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 295-346 2.13e-03

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 36.97  E-value: 2.13e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2462554939  295 FGYSLSGQMDVDENFYPDLLVGS-LSDHIVLLRARPVINIVHKTLVPRPAVLD 346
Cdd:smart00191   5 FGYSVAGVGDVNGDGYPDLLVGApRANDAGETGAVYVYFGSSGGGNSIPLQNL 57
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 246-282 2.67e-03

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 36.97  E-value: 2.67e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 2462554939  246 GNLYIDIAVGAPFEG----LGKVYIYHSSSKGLLRQPQQVI 282
Cdd:smart00191  17 GDGYPDLLVGAPRANdageTGAVYVYFGSSGGGNSIPLQNL 57
 
Name Accession Description Interval E-value
Integrin_alpha2 pfam08441
Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C ...
 328-781 7.85e-115

Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of pfam01839 repeats and to the N-terminus of the pfam00357 cytoplasmic region. This region is composed of three immunoglobulin-like domains.


Pssm-ID: 462478 [Multi-domain]  Cd Length: 449  Bit Score: 358.94  E-value: 7.85e-115
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462554939 328 RPVINIVhKTLVPRPAVLDPA--LCTAT----SCVQVELCFAYNqsaGNPNYRRNITLAYTLEADRDRRPPRLR----FA 397
Cdd:pfam08441   1 RPVVSVS-ASLQVEPNSINPEkkNCTLTgtpvSCFTVRACFSYT---GKPIPNPSLVLNYELELDRQKKKGLPPrvlfLD 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462554939 398 GSESAVFHGFFSMPEMR--CQKLELLLMDNLRDKLRPIIISMNYSLplRMPDRPRLGLRSLDayPILNQAQALENHTEVQ 475
Cdd:pfam08441  77 SQQPSLTGTLVLLSQGRkvCRTTKAYLRDEFRDKLSPIVISLNYSL--RVDPRAPSDLPGLK--PILDQNQPSTVQEQAN 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462554939 476 FQKECGPDNKCESNLQMRAAFVSEQQQKLSRLQysrDVRKLLLSINVTNTrtsersGEDAHEALLTLVVPPALLLSSVRP 555
Cdd:pfam08441 153 FLKDCGEDNVCVPDLQLSAKFDSRESDEPLLLG---DDNDLALEITVTNL------GEDAYEAELYVTLPPGLDYSGVRR 223

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462554939 556 PGA-----CQANE-----TIFCELGNPFKRNQRMELLIAFEVIGVTLHTRDLQVQLQLSTSSHQD-NLWPMILTLLVDYT 624
Cdd:pfam08441 224 EGSekqlsCTAKKenstrQVVCDLGNPMKRGTQVTFGLRFSVSGLELSTEELSFDLQIRSTNEQNsNSNPVSLKVPVVAE 303

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462554939 625 LQTSLSMVNHRLQsFFGGTVMGESGMK--TVEDVGSPLKYEFQVGPMGEGLVglGTLVLGLEWPYEVSNGKWLLYPTEIT 702
Cdd:pfam08441 304 AQLSLSGVSKPDQ-VVGGSVKGESAMKprSEEDIGPLVEHTYEVINNGPSTV--SGASLEISWPYELSNGKWLLYLLDVQ 380

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462554939 703 VHGNGSwpCRPPgDLINPLNLTLSDPGDRPSSPQRRRRQLDPGGGQGPPPvtlaaaKKAKSETVLTCATGrAHCVWLEC 781
Cdd:pfam08441 381 GQGKGE--CSPQ-NEINPLNLTQSLESSKPLRTSRVHHVVKRRDVLKSEK------ATQTASVLLSCDSG-ARCVVIRC 449
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 48-108 1.04e-07

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 49.30  E-value: 1.04e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462554939   48 PGSLFGYSVALHRQTERQQRYLLLAGAPRelavpDGFTNRTGAVYLCPLTAHKDDCERMNI 108
Cdd:smart00191   1 PGSYFGYSVAGVGDVNGDGYPDLLVGAPR-----ANDAGETGAVYVYFGSSGGGNSIPLQN 56
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 295-346 2.13e-03

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 36.97  E-value: 2.13e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2462554939  295 FGYSLSGQMDVDENFYPDLLVGS-LSDHIVLLRARPVINIVHKTLVPRPAVLD 346
Cdd:smart00191   5 FGYSVAGVGDVNGDGYPDLLVGApRANDAGETGAVYVYFGSSGGGNSIPLQNL 57
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 246-282 2.67e-03

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 36.97  E-value: 2.67e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 2462554939  246 GNLYIDIAVGAPFEG----LGKVYIYHSSSKGLLRQPQQVI 282
Cdd:smart00191  17 GDGYPDLLVGAPRANdageTGAVYVYFGSSGGGNSIPLQNL 57
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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