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Conserved domains on  [gi|2462563344|ref|XP_054175982|]
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zinc finger protein 555 isoform X2 [Homo sapiens]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12016853)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 5-46 1.25e-22

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 90.61  E-value: 1.25e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 2462563344   5 SVVFEDVAVDFTLEEWALLDSAQRDLYRDVMLETFQNLASVD 46
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
199-596 2.00e-14

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 75.89  E-value: 2.00e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563344 199 RPYVCKLCGKTFPRTSSLNRHVRIHTAEKTYEC--KQCGKAFIDFSSLTSHLRSHTGEKPYKC-KECGKAFSYSSTFRRH 275
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563344 276 TITHTGEKPYKCKECAEAFSYSSTFRRHMISHTGEKPHKCKEC-GEAFSYSSAFRRHMITHTGEKPyeckqcgKTFIYLQ 354
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPANSLS-------KDPSSNL 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563344 355 SFRRHERIHTGEKPYECKQCGKTFIYPQSFRRHERTHGGEKPYECNQCGKAFSH------PSSFRGHMRVHTGEKPYECK 428
Cdd:COG5048   185 SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKsllsqsPSSLSSSDSSSSASESPRSS 264

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563344 429 QCGKTFNWPISLRKHMRTHTR-EKPYECKQCGKAFSLSACFREHVRMH----PEDKSYEC--KLCGKAFYCHISLQKHMR 501
Cdd:COG5048   265 LPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSVnhsgESLKPFSCpySLCGKLFSRNDALKRHIL 344

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563344 502 RHTAEKLYKCKQC-------GKAFSWPELLQQHVRTHTVEKPYEC--KECGKVFKWPSSLPIHMRLHTGEKPYQCK--HC 570
Cdd:COG5048   345 LHTSISPAKEKLLnssskfsPLLNNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPC 424

                         410       420
                  ....*....|....*....|....*.
gi 2462563344 571 GKAFNCSSSLRRHVRIHTTEKQYKCN 596
Cdd:COG5048   425 SKSFNRHYNLIPHKKIHTNHAPLLCS 450
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 5-46 1.25e-22

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 90.61  E-value: 1.25e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 2462563344   5 SVVFEDVAVDFTLEEWALLDSAQRDLYRDVMLETFQNLASVD 46
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
6-50 4.45e-20

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 84.18  E-value: 4.45e-20
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 2462563344    6 VVFEDVAVDFTLEEWALLDSAQRDLYRDVMLETFQNLASVDDETQ 50
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVP 45
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 8-44 2.13e-18

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 78.75  E-value: 2.13e-18
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 2462563344   8 FEDVAVDFTLEEWALLDSAQRDLYRDVMLETFQNLAS 44
Cdd:cd07765     3 FEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVS 39
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
199-596 2.00e-14

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 75.89  E-value: 2.00e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563344 199 RPYVCKLCGKTFPRTSSLNRHVRIHTAEKTYEC--KQCGKAFIDFSSLTSHLRSHTGEKPYKC-KECGKAFSYSSTFRRH 275
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563344 276 TITHTGEKPYKCKECAEAFSYSSTFRRHMISHTGEKPHKCKEC-GEAFSYSSAFRRHMITHTGEKPyeckqcgKTFIYLQ 354
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPANSLS-------KDPSSNL 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563344 355 SFRRHERIHTGEKPYECKQCGKTFIYPQSFRRHERTHGGEKPYECNQCGKAFSH------PSSFRGHMRVHTGEKPYECK 428
Cdd:COG5048   185 SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKsllsqsPSSLSSSDSSSSASESPRSS 264

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563344 429 QCGKTFNWPISLRKHMRTHTR-EKPYECKQCGKAFSLSACFREHVRMH----PEDKSYEC--KLCGKAFYCHISLQKHMR 501
Cdd:COG5048   265 LPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSVnhsgESLKPFSCpySLCGKLFSRNDALKRHIL 344

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563344 502 RHTAEKLYKCKQC-------GKAFSWPELLQQHVRTHTVEKPYEC--KECGKVFKWPSSLPIHMRLHTGEKPYQCK--HC 570
Cdd:COG5048   345 LHTSISPAKEKLLnssskfsPLLNNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPC 424

                         410       420
                  ....*....|....*....|....*.
gi 2462563344 571 GKAFNCSSSLRRHVRIHTTEKQYKCN 596
Cdd:COG5048   425 SKSFNRHYNLIPHKKIHTNHAPLLCS 450
zf-H2C2_2 pfam13465
Zinc-finger double domain;
439-463 1.31e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.31e-04
                          10        20
                  ....*....|....*....|....*
gi 2462563344 439 SLRKHMRTHTREKPYECKQCGKAFS 463
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
PHA00733 PHA00733
hypothetical protein
 200-248 7.58e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 37.16  E-value: 7.58e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 2462563344 200 PYVCKLCGKTFPRTSSLNRHVRIhtAEKTYECKQCGKAFIDFSSLTSHL 248
Cdd:PHA00733   73 PYVCPLCLMPFSSSVSLKQHIRY--TEHSKVCPVCGKEFRNTDSTLDHV 119
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 5-46 1.25e-22

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 90.61  E-value: 1.25e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 2462563344   5 SVVFEDVAVDFTLEEWALLDSAQRDLYRDVMLETFQNLASVD 46
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
6-50 4.45e-20

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 84.18  E-value: 4.45e-20
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 2462563344    6 VVFEDVAVDFTLEEWALLDSAQRDLYRDVMLETFQNLASVDDETQ 50
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVP 45
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 8-44 2.13e-18

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 78.75  E-value: 2.13e-18
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 2462563344   8 FEDVAVDFTLEEWALLDSAQRDLYRDVMLETFQNLAS 44
Cdd:cd07765     3 FEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVS 39
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
199-596 2.00e-14

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 75.89  E-value: 2.00e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563344 199 RPYVCKLCGKTFPRTSSLNRHVRIHTAEKTYEC--KQCGKAFIDFSSLTSHLRSHTGEKPYKC-KECGKAFSYSSTFRRH 275
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563344 276 TITHTGEKPYKCKECAEAFSYSSTFRRHMISHTGEKPHKCKEC-GEAFSYSSAFRRHMITHTGEKPyeckqcgKTFIYLQ 354
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPANSLS-------KDPSSNL 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563344 355 SFRRHERIHTGEKPYECKQCGKTFIYPQSFRRHERTHGGEKPYECNQCGKAFSH------PSSFRGHMRVHTGEKPYECK 428
Cdd:COG5048   185 SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKsllsqsPSSLSSSDSSSSASESPRSS 264

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563344 429 QCGKTFNWPISLRKHMRTHTR-EKPYECKQCGKAFSLSACFREHVRMH----PEDKSYEC--KLCGKAFYCHISLQKHMR 501
Cdd:COG5048   265 LPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSVnhsgESLKPFSCpySLCGKLFSRNDALKRHIL 344

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563344 502 RHTAEKLYKCKQC-------GKAFSWPELLQQHVRTHTVEKPYEC--KECGKVFKWPSSLPIHMRLHTGEKPYQCK--HC 570
Cdd:COG5048   345 LHTSISPAKEKLLnssskfsPLLNNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPC 424

                         410       420
                  ....*....|....*....|....*.
gi 2462563344 571 GKAFNCSSSLRRHVRIHTTEKQYKCN 596
Cdd:COG5048   425 SKSFNRHYNLIPHKKIHTNHAPLLCS 450
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
208-469 1.04e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 54.70  E-value: 1.04e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563344 208 KTFPRTSSLNRHVRIHTAEKTYECKQCGKAFIDFSSLTSHLRSHTGEKPYKCKECGKAFSYSSTFRRHTITHTGEKPYKC 287
Cdd:COG5048   178 KDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSA 257

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563344 288 KECAEAFSYSSTFRRHMISHTGE-------KPHKCKECGEAFSYSSAFRRHM--ITHTGE--KPYEC--KQCGKTFIYLQ 354
Cdd:COG5048   258 SESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCpySLCGKLFSRND 337

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563344 355 SFRRHERIHTGEKPYECK--QCGKTF-----IYPQSFRRHERTHGGEKPYEC--NQCGKAFSHPSSFRGHMRVHTGEKPY 425
Cdd:COG5048   338 ALKRHILLHTSISPAKEKllNSSSKFspllnNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPY 417

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 2462563344 426 ECK--QCGKTFNWPISLRKHMRTHTREKPYECKQCGKAFSLSACFR 469
Cdd:COG5048   418 NCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSN 463
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
122-388 7.87e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.01  E-value: 7.87e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563344 122 GEALSQIPHLNLYKKIPPGVKQYEYNTYGKVFMHRRTSLKSPITVHTGHK---PYQCQECGQAYSCRSHLRMHVRTHNGE 198
Cdd:COG5048   173 ANSLSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENsssSLPLTTNSQLSPKSLLSQSPSSLSSSD 252

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563344 199 RPYVCKLCG------KTFPRTSSLNRHVRIHTAEKT-YECKQCGKAFIDFSSLTSHLRS--HTGE--KPYKCKE--CGKA 265
Cdd:COG5048   253 SSSSASESPrsslptASSQSSSPNESDSSSEKGFSLpIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKL 332

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563344 266 FSYSSTFRRHTITHTGEKPYKCKEC-----------AEAFSYSSTFRRHMISHTGEKPHKCKEcgEAFSYSSAFRRHMIT 334
Cdd:COG5048   333 FSRNDALKRHILLHTSISPAKEKLLnssskfspllnNEPPQSLQQYKDLKNDKKSETLSNSCI--RNFKRDSNLSLHIIT 410

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462563344 335 HTGEKPYECK--QCGKTFIYLQSFRRHERIHTGEKPYECKQCGKTFIYPQSFRRHE 388
Cdd:COG5048   411 HLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
283-601 4.96e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 49.31  E-value: 4.96e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563344 283 KPYKCKECAEAFSYSSTFRRHMISHTGEKPHKCKECGEAFSYS--SAFRRHMITHTGEKPYECKQCGKTFIYLQSFRRHE 360
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSrpLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563344 361 RIHTGE-KPYECKQCGKTFIYPQSFRRHERTH---GGEKPYECNQCGKAFSHPSSFRGHMRVHTgekpyeckQCGKTFNW 436
Cdd:COG5048   112 SSSSNSnDNNLLSSHSLPPSSRDPQLPDLLSIsnlRNNPLPGNNSSSVNTPQSNSLHPPLPANS--------LSKDPSSN 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563344 437 PISLRKHMRTHTREKPYECKQCGKAFSLSACFREHVRMHPEDkSYECKLCGKAfyCHISLQKHMRRHTAEKLYK--CKQC 514
Cdd:COG5048   184 LSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSS-SLPLTTNSQL--SPKSLLSQSPSSLSSSDSSssASES 260

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563344 515 GKAFSWPELLQQ--HVRTHTVE-----KPYECKECGKVFKWPSSLPIHMR--LHTGE--KPYQCKH--CGKAFNCSSSLR 581
Cdd:COG5048   261 PRSSLPTASSQSssPNESDSSSekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALK 340

                         330       340
                  ....*....|....*....|
gi 2462563344 582 RHVRIHTTEKQYKCNVGHPP 601
Cdd:COG5048   341 RHILLHTSISPAKEKLLNSS 360
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
535-628 1.30e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.69  E-value: 1.30e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563344 535 KPYECKECGKVFKWPSSLPIHMRLHTGEKPYQCKHCGKAFNCS--SSLRRHVRIHTTEKQYKCNVGHPPANEF--MCSAS 610
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSrpLELSRHLRTHHNNPSDLNSKSLPLSNSKasSSSLS 111

                          90
                  ....*....|....*...
gi 2462563344 611 EKSHQERDLIKVVNMVLP 628
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLP 129
zf-H2C2_2 pfam13465
Zinc-finger double domain;
439-463 1.31e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.31e-04
                          10        20
                  ....*....|....*....|....*
gi 2462563344 439 SLRKHMRTHTREKPYECKQCGKAFS 463
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
327-352 1.75e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.75e-04
                          10        20
                  ....*....|....*....|....*.
gi 2462563344 327 AFRRHMITHTGEKPYECKQCGKTFIY 352
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
243-268 2.03e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 2.03e-04
                          10        20
                  ....*....|....*....|....*.
gi 2462563344 243 SLTSHLRSHTGEKPYKCKECGKAFSY 268
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
355-380 2.11e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 2.11e-04
                          10        20
                  ....*....|....*....|....*.
gi 2462563344 355 SFRRHERIHTGEKPYECKQCGKTFIY 380
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
524-547 3.07e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 3.07e-04
                          10        20
                  ....*....|....*....|....
gi 2462563344 524 LQQHVRTHTVEKPYECKECGKVFK 547
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
300-324 3.48e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 3.48e-04
                          10        20
                  ....*....|....*....|....*
gi 2462563344 300 FRRHMISHTGEKPHKCKECGEAFSY 324
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
383-408 5.92e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 5.92e-04
                          10        20
                  ....*....|....*....|....*.
gi 2462563344 383 SFRRHERTHGGEKPYECNQCGKAFSH 408
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
555-576 8.76e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 8.76e-04
                          10        20
                  ....*....|....*....|..
gi 2462563344 555 HMRLHTGEKPYQCKHCGKAFNC 576
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
415-435 1.50e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.50e-03
                          10        20
                  ....*....|....*....|.
gi 2462563344 415 HMRVHTGEKPYECKQCGKTFN 435
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
495-519 1.83e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.83e-03
                          10        20
                  ....*....|....*....|....*
gi 2462563344 495 SLQKHMRRHTAEKLYKCKQCGKAFS 519
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
215-238 3.27e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.27e-03
                          10        20
                  ....*....|....*....|....
gi 2462563344 215 SLNRHVRIHTAEKTYECKQCGKAF 238
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
187-210 4.30e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 4.30e-03
                          10        20
                  ....*....|....*....|....
gi 2462563344 187 HLRMHVRTHNGERPYVCKLCGKTF 210
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
272-296 5.72e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 5.72e-03
                          10        20
                  ....*....|....*....|....*
gi 2462563344 272 FRRHTITHTGEKPYKCKECAEAFSY 296
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
PHA00733 PHA00733
hypothetical protein
 200-248 7.58e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 37.16  E-value: 7.58e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 2462563344 200 PYVCKLCGKTFPRTSSLNRHVRIhtAEKTYECKQCGKAFIDFSSLTSHL 248
Cdd:PHA00733   73 PYVCPLCLMPFSSSVSLKQHIRY--TEHSKVCPVCGKEFRNTDSTLDHV 119
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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