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Conserved domains on  [gi|2462563536|ref|XP_054176077|]
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zinc finger protein 676 isoform X2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
223-664 6.64e-15

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 77.81  E-value: 6.64e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563536 223 KPYKCEECGKAFNRSSILTKHKIIHTGEKPYKC--EECGKAFNSSSNLMEHKRVHTGEKPYKCE-ECGKAFSWSSSLTEH 299
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563536 300 KRIHAGEKPYKCEECGKAFNRSSILTKHKIIHTGEKPYKCEEC-GKGFSSVSTLNTHKAIHAEEKPYKCEECGKASNSSS 378
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563536 379 KlmehkrIHTGEKPYKCEECGKAFSWSSSLTEHKRIHAgEKPYKCEECGKAFNRSSILTKH-KIIHTGEKPYKCEGCGKA 457
Cdd:COG5048   192 V------STSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSLLSQSPsSLSSSDSSSSASESPRSS 264

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563536 458 FSKVSTLNTHKAIHAEEK------PYKCEECGKASNSSSKLMEHKR--IHTGE--KPYKCEE--CGKAFSWSSSLTEHKR 525
Cdd:COG5048   265 LPTASSQSSSPNESDSSSekgfslPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHIL 344

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563536 526 IHAGEKPYKCeecgkafTWSSSFTKHKRIHAAEKPykceecgkgfstfSILTKHKIIHTGEKRYKCEECGKAFSWS-SIL 604
Cdd:COG5048   345 LHTSISPAKE-------KLLNSSSKFSPLLNNEPP-------------QSLQQYKDLKNDKKSETLSNSCIRNFKRdSNL 404

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462563536 605 TEHKIIHTGEKP--YKCEECGKAFSRSSSLTRHKRIHTGEKPYKCEECGKAFKSSSTVSYHK 664
Cdd:COG5048   405 SLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
KRAB super family cl42959
krueppel associated box;
1-32 1.50e-11

krueppel associated box;


The actual alignment was detected with superfamily member smart00349:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 59.91  E-value: 1.50e-11
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2462563536    1 MLENYRNLVFLGIAAFKPDLIIFLEQGKEPWN 32
Cdd:smart00349  30 MLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
223-664 6.64e-15

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 77.81  E-value: 6.64e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563536 223 KPYKCEECGKAFNRSSILTKHKIIHTGEKPYKC--EECGKAFNSSSNLMEHKRVHTGEKPYKCE-ECGKAFSWSSSLTEH 299
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563536 300 KRIHAGEKPYKCEECGKAFNRSSILTKHKIIHTGEKPYKCEEC-GKGFSSVSTLNTHKAIHAEEKPYKCEECGKASNSSS 378
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563536 379 KlmehkrIHTGEKPYKCEECGKAFSWSSSLTEHKRIHAgEKPYKCEECGKAFNRSSILTKH-KIIHTGEKPYKCEGCGKA 457
Cdd:COG5048   192 V------STSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSLLSQSPsSLSSSDSSSSASESPRSS 264

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563536 458 FSKVSTLNTHKAIHAEEK------PYKCEECGKASNSSSKLMEHKR--IHTGE--KPYKCEE--CGKAFSWSSSLTEHKR 525
Cdd:COG5048   265 LPTASSQSSSPNESDSSSekgfslPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHIL 344

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563536 526 IHAGEKPYKCeecgkafTWSSSFTKHKRIHAAEKPykceecgkgfstfSILTKHKIIHTGEKRYKCEECGKAFSWS-SIL 604
Cdd:COG5048   345 LHTSISPAKE-------KLLNSSSKFSPLLNNEPP-------------QSLQQYKDLKNDKKSETLSNSCIRNFKRdSNL 404

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462563536 605 TEHKIIHTGEKP--YKCEECGKAFSRSSSLTRHKRIHTGEKPYKCEECGKAFKSSSTVSYHK 664
Cdd:COG5048   405 SLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
KRAB smart00349
krueppel associated box;
1-32 1.50e-11

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 59.91  E-value: 1.50e-11
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2462563536    1 MLENYRNLVFLGIAAFKPDLIIFLEQGKEPWN 32
Cdd:smart00349  30 MLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
zf-H2C2_2 pfam13465
Zinc-finger double domain;
631-656 7.59e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.05  E-value: 7.59e-05
                          10        20
                  ....*....|....*....|....*.
gi 2462563536 631 SLTRHKRIHTGEKPYKCEECGKAFKS 656
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
223-664 6.64e-15

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 77.81  E-value: 6.64e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563536 223 KPYKCEECGKAFNRSSILTKHKIIHTGEKPYKC--EECGKAFNSSSNLMEHKRVHTGEKPYKCE-ECGKAFSWSSSLTEH 299
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563536 300 KRIHAGEKPYKCEECGKAFNRSSILTKHKIIHTGEKPYKCEEC-GKGFSSVSTLNTHKAIHAEEKPYKCEECGKASNSSS 378
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563536 379 KlmehkrIHTGEKPYKCEECGKAFSWSSSLTEHKRIHAgEKPYKCEECGKAFNRSSILTKH-KIIHTGEKPYKCEGCGKA 457
Cdd:COG5048   192 V------STSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSLLSQSPsSLSSSDSSSSASESPRSS 264

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563536 458 FSKVSTLNTHKAIHAEEK------PYKCEECGKASNSSSKLMEHKR--IHTGE--KPYKCEE--CGKAFSWSSSLTEHKR 525
Cdd:COG5048   265 LPTASSQSSSPNESDSSSekgfslPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHIL 344

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563536 526 IHAGEKPYKCeecgkafTWSSSFTKHKRIHAAEKPykceecgkgfstfSILTKHKIIHTGEKRYKCEECGKAFSWS-SIL 604
Cdd:COG5048   345 LHTSISPAKE-------KLLNSSSKFSPLLNNEPP-------------QSLQQYKDLKNDKKSETLSNSCIRNFKRdSNL 404

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462563536 605 TEHKIIHTGEKP--YKCEECGKAFSRSSSLTRHKRIHTGEKPYKCEECGKAFKSSSTVSYHK 664
Cdd:COG5048   405 SLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
KRAB smart00349
krueppel associated box;
1-32 1.50e-11

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 59.91  E-value: 1.50e-11
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2462563536    1 MLENYRNLVFLGIAAFKPDLIIFLEQGKEPWN 32
Cdd:smart00349  30 MLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
347-659 6.66e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.39  E-value: 6.66e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563536 347 SSVSTLNTHKAIHAEEKPYKCEECGKASNSSSKLMEHKRIHTGEKPYKC--EECGKAFSWSSSLTEHKRIHAGEKPYkcE 424
Cdd:COG5048    16 LSSTPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSD--L 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563536 425 ECGKAFNRSSILTKHKIIHTGEKPYKCE-----GCGKAFSKVSTLNTHKAIHAEEKPYK--------------------- 478
Cdd:COG5048    94 NSKSLPLSNSKASSSSLSSSSSNSNDNNllsshSLPPSSRDPQLPDLLSISNLRNNPLPgnnsssvntpqsnslhpplpa 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563536 479 CEECGKASNSSSKLMEHKRIHTGEKPYKCEECGKAFSWSSSLTEHKRIHAgEKPYKCEECGKAF-----TWSSSFTKHK- 552
Cdd:COG5048   174 NSLSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSpksllSQSPSSLSSSd 252

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563536 553 RIHAAEKPYKCEECGKGFSTFSILTKHKIIHTG-EKRYKCEECGKAFSWSSILTEHK--IIHTGE--KPYKCEE--CGKA 625
Cdd:COG5048   253 SSSSASESPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKL 332

                         330       340       350
                  ....*....|....*....|....*....|....*.
gi 2462563536 626 FSRSSSLTRHKRIHTGEKPYKC--EECGKAFKSSST 659
Cdd:COG5048   333 FSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLN 368
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
307-469 3.04e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.08  E-value: 3.04e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563536 307 KPYKCEECGKAFNRSSILTKHK--IIHTGE--KPYKCEE--CGKGFSSVSTLNTHKAIHAEEKPYKCEEC--------GK 372
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLnssskfspLL 367

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563536 373 ASNSSSKLMEHKRIHTGEKPYKCEECGKAFSWSSS-LTEHKRIHAGEKP--YKCEECGKAFNRSSILTKHKIIHTGEKPY 449
Cdd:COG5048   368 NNEPPQSLQQYKDLKNDKKSETLSNSCIRNFKRDSnLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPL 447

                         170       180
                  ....*....|....*....|
gi 2462563536 450 KCEGCGKAFSKVSTLNTHKA 469
Cdd:COG5048   448 LCSILKSFRRDLDLSNHGKD 467
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
167-328 1.35e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.15  E-value: 1.35e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563536 167 NSYKCEENGKAFNWSSTLT--YYKSIHTGE--KPYKCEE--CGKAFSKFSILTKHKVIHTGEKPYKC--EECGKAFNRSS 238
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTrhLRSVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLL 367

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563536 239 I------LTKHKIIHTGEKPYKCE-ECGKAFNSSSNLMEHKRVHTGEKP--YKCEECGKAFSWSSSLTEHKRIHAGEKPY 309
Cdd:COG5048   368 NneppqsLQQYKDLKNDKKSETLSnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPL 447

                         170
                  ....*....|....*....
gi 2462563536 310 KCEECGKAFNRSSILTKHK 328
Cdd:COG5048   448 LCSILKSFRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
631-656 7.59e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.05  E-value: 7.59e-05
                          10        20
                  ....*....|....*....|....*.
gi 2462563536 631 SLTRHKRIHTGEKPYKCEECGKAFKS 656
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 613-665 1.33e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 44.71  E-value: 1.33e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462563536 613 GEKPYKCE--ECGKAFSRSSSLTRHKR-------------------IHTGEKPYKCEECGKAFKSSSTVSYHKK 665
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHMLhghqnqklhenpspekmniFSAKDKPYRCEVCDKRYKNLNGLKYHRK 419
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
615-672 2.12e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.30  E-value: 2.12e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563536 615 KPYKCEECGKAFSRSSSLTRHKRIHTGEKPYKC--EECGKAFKSSSTVSYHKKIHTGENP 672
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPS 91
zf-H2C2_2 pfam13465
Zinc-finger double domain;
267-291 2.17e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 2.17e-04
                          10        20
                  ....*....|....*....|....*
gi 2462563536 267 NLMEHKRVHTGEKPYKCEECGKAFS 291
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
380-403 2.85e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 2.85e-04
                          10        20
                  ....*....|....*....|....
gi 2462563536 380 LMEHKRIHTGEKPYKCEECGKAFS 403
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
492-515 2.85e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 2.85e-04
                          10        20
                  ....*....|....*....|....
gi 2462563536 492 LMEHKRIHTGEKPYKCEECGKAFS 515
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 277-356 2.86e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.94  E-value: 2.86e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563536 277 GEKPYKCE--ECGKAFSWSSSLTEHkRIHAGEKPYKCEecgkafNRSSIltKHKIIHTGEKPYKCEECGKGFSSVSTLNT 354
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYH-MLHGHQNQKLHE------NPSPE--KMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ..
gi 2462563536 355 HK 356
Cdd:COG5189   417 HR 418
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 389-468 3.20e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.55  E-value: 3.20e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563536 389 GEKPYKCE--ECGKAFSWSSSLTEHkRIHAGEKPYKCEecgkafNRSSIltKHKIIHTGEKPYKCEGCGKAFSKVSTLNT 466
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYH-MLHGHQNQKLHE------NPSPE--KMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ..
gi 2462563536 467 HK 468
Cdd:COG5189   417 HR 418
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 501-580 4.56e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.17  E-value: 4.56e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563536 501 GEKPYKCE--ECGKAFSWSSSLTEHkRIHAgekpykceECGKAFTWSSSFTKHKRIHAAEKPYKCEECGKGFSTFSILTK 578
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYH-MLHG--------HQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ..
gi 2462563536 579 HK 580
Cdd:COG5189   417 HR 418
zf-H2C2_2 pfam13465
Zinc-finger double domain;
240-264 1.62e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.62e-03
                          10        20
                  ....*....|....*....|....*
gi 2462563536 240 LTKHKIIHTGEKPYKCEECGKAFNS 264
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
604-628 1.81e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.81e-03
                          10        20
                  ....*....|....*....|....*
gi 2462563536 604 LTEHKIIHTGEKPYKCEECGKAFSR 628
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 417-496 1.94e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.24  E-value: 1.94e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563536 417 GEKPYKCE--ECGKAFNRSSILTKHKIihtgekpykcEG-CGKAFSKVSTLNTHKAIHAEEKPYKCEECGKASNSSSKLM 493
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHML----------HGhQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLK 415


                  ...
gi 2462563536 494 EHK 496
Cdd:COG5189   416 YHR 418
zf-H2C2_2 pfam13465
Zinc-finger double domain;
407-432 2.13e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.13e-03
                          10        20
                  ....*....|....*....|....*.
gi 2462563536 407 SLTEHKRIHAGEKPYKCEECGKAFNR 432
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
295-320 2.13e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.13e-03
                          10        20
                  ....*....|....*....|....*.
gi 2462563536 295 SLTEHKRIHAGEKPYKCEECGKAFNR 320
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 617-639 2.56e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.74  E-value: 2.56e-03
                          10        20
                  ....*....|....*....|...
gi 2462563536 617 YKCEECGKAFSRSSSLTRHKRIH 639
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
212-236 2.57e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.57e-03
                          10        20
                  ....*....|....*....|....*
gi 2462563536 212 LTKHKVIHTGEKPYKCEECGKAFNR 236
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 305-384 3.85e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.09  E-value: 3.85e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563536 305 GEKPYKCE--ECGKAFNRSSILTKHKiihtgekpyKCEECGKGFSSVSTLNTHKAIHAEEKPYKCEECGKASNSSSKLME 382
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ..
gi 2462563536 383 HK 384
Cdd:COG5189   417 HR 418
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 193-272 4.09e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.09  E-value: 4.09e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563536 193 GEKPYKCE--ECGKAFSKFSILTKHKvIHTGEKPYKCEecgkafNRSSIltKHKIIHTGEKPYKCEECGKAFNSSSNLME 270
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHM-LHGHQNQKLHE------NPSPE--KMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ..
gi 2462563536 271 HK 272
Cdd:COG5189   417 HR 418
zf-H2C2_2 pfam13465
Zinc-finger double domain;
519-543 4.12e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 4.12e-03
                          10        20
                  ....*....|....*....|....*
gi 2462563536 519 SLTEHKRIHAGEKPYKCEECGKAFT 543
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
324-348 4.50e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 4.50e-03
                          10        20
                  ....*....|....*....|....*
gi 2462563536 324 LTKHKIIHTGEKPYKCEECGKGFSS 348
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
436-460 9.79e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 9.79e-03
                          10        20
                  ....*....|....*....|....*
gi 2462563536 436 LTKHKIIHTGEKPYKCEGCGKAFSK 460
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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