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Conserved domains on  [gi|2462563542|ref|XP_054176080|]
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zinc finger protein 676 isoform X5 [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
158-599 4.96e-14

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 74.73  E-value: 4.96e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563542 158 KPYKCEECGKAFNRSSILTKHKIIHTGEKPYKC--EECGKAFNSSSNLMEHKRVHTGEKPYKCE-ECGKAFSWSSSLTEH 234
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563542 235 KRIHAGEKPYKCEECGKAFNRSSILTKHKIIHTGEKPYKCEEC-GKGFSSVSTLNTHKAIHAEEKPYKCEECGKASNSSS 313
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563542 314 KlmehkrIHTGEKPYKCEECGKAFSWSSSLTEHKRIHAgEKPYKCEECGKAFNRSSILTKH-KIIHTGEKPYKCEGCGKA 392
Cdd:COG5048   192 V------STSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSLLSQSPsSLSSSDSSSSASESPRSS 264

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563542 393 FSKVSTLNTHKAIHAEEK------PYKCEECGKASNSSSKLMEHKR--IHTGE--KPYKCEE--CGKAFSWSSSLTEHKR 460
Cdd:COG5048   265 LPTASSQSSSPNESDSSSekgfslPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHIL 344

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563542 461 IHAGEKPYKCeecgkafTWSSSFTKHKRIHAAEKPykceecgkgfstfSILTKHKIIHTGEKRYKCEECGKAFSWS-SIL 539
Cdd:COG5048   345 LHTSISPAKE-------KLLNSSSKFSPLLNNEPP-------------QSLQQYKDLKNDKKSETLSNSCIRNFKRdSNL 404

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462563542 540 TEHKIIHTGEKP--YKCEECGKAFSRSSSLTRHKRIHTGEKPYKCEECGKAFKSSSTVSYHK 599
Cdd:COG5048   405 SLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
158-599 4.96e-14

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 74.73  E-value: 4.96e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563542 158 KPYKCEECGKAFNRSSILTKHKIIHTGEKPYKC--EECGKAFNSSSNLMEHKRVHTGEKPYKCE-ECGKAFSWSSSLTEH 234
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563542 235 KRIHAGEKPYKCEECGKAFNRSSILTKHKIIHTGEKPYKCEEC-GKGFSSVSTLNTHKAIHAEEKPYKCEECGKASNSSS 313
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563542 314 KlmehkrIHTGEKPYKCEECGKAFSWSSSLTEHKRIHAgEKPYKCEECGKAFNRSSILTKH-KIIHTGEKPYKCEGCGKA 392
Cdd:COG5048   192 V------STSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSLLSQSPsSLSSSDSSSSASESPRSS 264

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563542 393 FSKVSTLNTHKAIHAEEK------PYKCEECGKASNSSSKLMEHKR--IHTGE--KPYKCEE--CGKAFSWSSSLTEHKR 460
Cdd:COG5048   265 LPTASSQSSSPNESDSSSekgfslPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHIL 344

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563542 461 IHAGEKPYKCeecgkafTWSSSFTKHKRIHAAEKPykceecgkgfstfSILTKHKIIHTGEKRYKCEECGKAFSWS-SIL 539
Cdd:COG5048   345 LHTSISPAKE-------KLLNSSSKFSPLLNNEPP-------------QSLQQYKDLKNDKKSETLSNSCIRNFKRdSNL 404

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462563542 540 TEHKIIHTGEKP--YKCEECGKAFSRSSSLTRHKRIHTGEKPYKCEECGKAFKSSSTVSYHK 599
Cdd:COG5048   405 SLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
566-591 1.45e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.45e-04
                          10        20
                  ....*....|....*....|....*.
gi 2462563542 566 SLTRHKRIHTGEKPYKCEECGKAFKS 591
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
158-599 4.96e-14

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 74.73  E-value: 4.96e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563542 158 KPYKCEECGKAFNRSSILTKHKIIHTGEKPYKC--EECGKAFNSSSNLMEHKRVHTGEKPYKCE-ECGKAFSWSSSLTEH 234
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563542 235 KRIHAGEKPYKCEECGKAFNRSSILTKHKIIHTGEKPYKCEEC-GKGFSSVSTLNTHKAIHAEEKPYKCEECGKASNSSS 313
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563542 314 KlmehkrIHTGEKPYKCEECGKAFSWSSSLTEHKRIHAgEKPYKCEECGKAFNRSSILTKH-KIIHTGEKPYKCEGCGKA 392
Cdd:COG5048   192 V------STSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSLLSQSPsSLSSSDSSSSASESPRSS 264

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563542 393 FSKVSTLNTHKAIHAEEK------PYKCEECGKASNSSSKLMEHKR--IHTGE--KPYKCEE--CGKAFSWSSSLTEHKR 460
Cdd:COG5048   265 LPTASSQSSSPNESDSSSekgfslPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHIL 344

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563542 461 IHAGEKPYKCeecgkafTWSSSFTKHKRIHAAEKPykceecgkgfstfSILTKHKIIHTGEKRYKCEECGKAFSWS-SIL 539
Cdd:COG5048   345 LHTSISPAKE-------KLLNSSSKFSPLLNNEPP-------------QSLQQYKDLKNDKKSETLSNSCIRNFKRdSNL 404

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462563542 540 TEHKIIHTGEKP--YKCEECGKAFSRSSSLTRHKRIHTGEKPYKCEECGKAFKSSSTVSYHK 599
Cdd:COG5048   405 SLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
282-594 3.00e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.08  E-value: 3.00e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563542 282 SSVSTLNTHKAIHAEEKPYKCEECGKASNSSSKLMEHKRIHTGEKPYKC--EECGKAFSWSSSLTEHKRIHAGEKPYkcE 359
Cdd:COG5048    16 LSSTPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSD--L 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563542 360 ECGKAFNRSSILTKHKIIHTGEKPYKCE-----GCGKAFSKVSTLNTHKAIHAEEKPYK--------------------- 413
Cdd:COG5048    94 NSKSLPLSNSKASSSSLSSSSSNSNDNNllsshSLPPSSRDPQLPDLLSISNLRNNPLPgnnsssvntpqsnslhpplpa 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563542 414 CEECGKASNSSSKLMEHKRIHTGEKPYKCEECGKAFSWSSSLTEHKRIHAgEKPYKCEECGKAF-----TWSSSFTKHK- 487
Cdd:COG5048   174 NSLSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSpksllSQSPSSLSSSd 252

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563542 488 RIHAAEKPYKCEECGKGFSTFSILTKHKIIHTG-EKRYKCEECGKAFSWSSILTEHK--IIHTGE--KPYKCEE--CGKA 560
Cdd:COG5048   253 SSSSASESPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKL 332

                         330       340       350
                  ....*....|....*....|....*....|....*.
gi 2462563542 561 FSRSSSLTRHKRIHTGEKPYKC--EECGKAFKSSST 594
Cdd:COG5048   333 FSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLN 368
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
242-404 7.87e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.54  E-value: 7.87e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563542 242 KPYKCEECGKAFNRSSILTKHK--IIHTGE--KPYKCEE--CGKGFSSVSTLNTHKAIHAEEKPYKCEEC--------GK 307
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLnssskfspLL 367

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563542 308 ASNSSSKLMEHKRIHTGEKPYKCEECGKAFSWSSS-LTEHKRIHAGEKPY--KCEECGKAFNRSSILTKHKIIHTGEKPY 384
Cdd:COG5048   368 NNEPPQSLQQYKDLKNDKKSETLSNSCIRNFKRDSnLSLHIITHLSFRPYncKNPPCSKSFNRHYNLIPHKKIHTNHAPL 447

                         170       180
                  ....*....|....*....|
gi 2462563542 385 KCEGCGKAFSKVSTLNTHKA 404
Cdd:COG5048   448 LCSILKSFRRDLDLSNHGKD 467
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
102-263 3.69e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 46.61  E-value: 3.69e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563542 102 NSYKCEENGKAFNWSSTLT--YYKSIHTGE--KPYKCEE--CGKAFSKFSILTKHKVIHTGEKPYKC--EECGKAFNRSS 173
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTrhLRSVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLL 367

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563542 174 I------LTKHKIIHTGEKPYKCE-ECGKAFNSSSNLMEHKRVHTGEKP--YKCEECGKAFSWSSSLTEHKRIHAGEKPY 244
Cdd:COG5048   368 NneppqsLQQYKDLKNDKKSETLSnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPL 447

                         170
                  ....*....|....*....
gi 2462563542 245 KCEECGKAFNRSSILTKHK 263
Cdd:COG5048   448 LCSILKSFRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
566-591 1.45e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.45e-04
                          10        20
                  ....*....|....*....|....*.
gi 2462563542 566 SLTRHKRIHTGEKPYKCEECGKAFKS 591
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 548-600 1.67e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 44.32  E-value: 1.67e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462563542 548 GEKPYKCE--ECGKAFSRSSSLTRHKR-------------------IHTGEKPYKCEECGKAFKSSSTVSYHKK 600
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHMLhghqnqklhenpspekmniFSAKDKPYRCEVCDKRYKNLNGLKYHRK 419
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
550-607 3.54e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.53  E-value: 3.54e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563542 550 KPYKCEECGKAFSRSSSLTRHKRIHTGEKPYKC--EECGKAFKSSSTVSYHKKIHTGENP 607
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPS 91
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 212-291 3.60e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.17  E-value: 3.60e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563542 212 GEKPYKCE--ECGKAFSWSSSLTEHkRIHAGEKPYKCEecgkafNRSSIltKHKIIHTGEKPYKCEECGKGFSSVSTLNT 289
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYH-MLHGHQNQKLHE------NPSPE--KMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ..
gi 2462563542 290 HK 291
Cdd:COG5189   417 HR 418
zf-H2C2_2 pfam13465
Zinc-finger double domain;
202-226 3.97e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 3.97e-04
                          10        20
                  ....*....|....*....|....*
gi 2462563542 202 NLMEHKRVHTGEKPYKCEECGKAFS 226
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 324-403 4.03e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.17  E-value: 4.03e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563542 324 GEKPYKCE--ECGKAFSWSSSLTEHkRIHAGEKPYKCEecgkafNRSSIltKHKIIHTGEKPYKCEGCGKAFSKVSTLNT 401
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYH-MLHGHQNQKLHE------NPSPE--KMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ..
gi 2462563542 402 HK 403
Cdd:COG5189   417 HR 418
zf-H2C2_2 pfam13465
Zinc-finger double domain;
315-338 5.13e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 5.13e-04
                          10        20
                  ....*....|....*....|....
gi 2462563542 315 LMEHKRIHTGEKPYKCEECGKAFS 338
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
427-450 5.13e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 5.13e-04
                          10        20
                  ....*....|....*....|....
gi 2462563542 427 LMEHKRIHTGEKPYKCEECGKAFS 450
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 436-515 5.60e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.78  E-value: 5.60e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563542 436 GEKPYKCE--ECGKAFSWSSSLTEHkRIHAgekpykceECGKAFTWSSSFTKHKRIHAAEKPYKCEECGKGFSTFSILTK 513
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYH-MLHG--------HQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ..
gi 2462563542 514 HK 515
Cdd:COG5189   417 HR 418
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 352-431 2.35e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.86  E-value: 2.35e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563542 352 GEKPYKCE--ECGKAFNRSSILTKHKIihtgekpykcEG-CGKAFSKVSTLNTHKAIHAEEKPYKCEECGKASNSSSKLM 428
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHML----------HGhQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLK 415


                  ...
gi 2462563542 429 EHK 431
Cdd:COG5189   416 YHR 418
zf-H2C2_2 pfam13465
Zinc-finger double domain;
175-199 2.83e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.83e-03
                          10        20
                  ....*....|....*....|....*
gi 2462563542 175 LTKHKIIHTGEKPYKCEECGKAFNS 199
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
539-563 3.09e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.09e-03
                          10        20
                  ....*....|....*....|....*
gi 2462563542 539 LTEHKIIHTGEKPYKCEECGKAFSR 563
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
342-367 3.69e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.69e-03
                          10        20
                  ....*....|....*....|....*.
gi 2462563542 342 SLTEHKRIHAGEKPYKCEECGKAFNR 367
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
230-255 3.69e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.69e-03
                          10        20
                  ....*....|....*....|....*.
gi 2462563542 230 SLTEHKRIHAGEKPYKCEECGKAFNR 255
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 240-319 4.46e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 39.70  E-value: 4.46e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563542 240 GEKPYKCE--ECGKAFNRSSILTKHKiihtgekpyKCEECGKGFSSVSTLNTHKAIHAEEKPYKCEECGKASNSSSKLME 317
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ..
gi 2462563542 318 HK 319
Cdd:COG5189   417 HR 418
zf-H2C2_2 pfam13465
Zinc-finger double domain;
147-171 4.49e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 4.49e-03
                          10        20
                  ....*....|....*....|....*
gi 2462563542 147 LTKHKVIHTGEKPYKCEECGKAFNR 171
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 552-574 4.79e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 4.79e-03
                          10        20
                  ....*....|....*....|...
gi 2462563542 552 YKCEECGKAFSRSSSLTRHKRIH 574
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 128-207 4.99e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 39.70  E-value: 4.99e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563542 128 GEKPYKCE--ECGKAFSKFSILTKHKvIHTGEKPYKCEecgkafNRSSIltKHKIIHTGEKPYKCEECGKAFNSSSNLME 205
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHM-LHGHQNQKLHE------NPSPE--KMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ..
gi 2462563542 206 HK 207
Cdd:COG5189   417 HR 418
zf-H2C2_2 pfam13465
Zinc-finger double domain;
454-478 6.99e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 6.99e-03
                          10        20
                  ....*....|....*....|....*
gi 2462563542 454 SLTEHKRIHAGEKPYKCEECGKAFT 478
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
259-283 7.57e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 7.57e-03
                          10        20
                  ....*....|....*....|....*
gi 2462563542 259 LTKHKIIHTGEKPYKCEECGKGFSS 283
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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