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Conserved domains on  [gi|2462563799|ref|XP_054176204|]
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serine/threonine-protein phosphatase 6 regulatory subunit 1 isoform X3 [Homo sapiens]

Protein Classification

SAPS family protein( domain architecture ID 10517350)

SAPS (SIT4-associating proteins) family protein

Gene Ontology:  GO:0019888|GO:0043666
PubMed:  8649382

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SAPS pfam04499
SIT4 phosphatase-associated protein; This family includes a conserved region from a group of ...
 128-519 6.98e-152

SIT4 phosphatase-associated protein; This family includes a conserved region from a group of yeast proteins that associate with the SIT4 phosphatase. This association is required for SIT4's role in G1 cyclin transcription and for bud formation. This family also includes homologous regions from other eukaryotes.


:

Pssm-ID: 398279  Cd Length: 383  Bit Score: 451.69  E-value: 6.98e-152
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563799 128 MGILINRKTDQLVSFLRKKDDFVDLLLQHIGTSAIMDLLLRLLTCVErPQLRQDVVNWLNEEKIVQRLIEQIHPSKDENQ 207
Cdd:pfam04499   1 NENLLDRKTDQMIEFIRKQENFVDKFLKHIDTPAIMDLLLKLISTDK-PELPTGVIEWLNEQNLIPKLLDLLSPSYDEDI 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563799 208 HSNASQSLCDIIRLSREQMIQVQDSPEPDQLLATLEKQETIEQLLSNMFEGeQSQSVIVSGIQVLLTLLEPRRPRSESVT 287
Cdd:pfam04499  80 QSNASDFLKAIITISRNAPLQLQSSIGPNELTRELVSEESVEKLLDNMLKG-KSGSALVNGVGIIIELIRKNNSDYDPVQ 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563799 288 VNSFfssvdgQLELLAQGALESTVSSVgALHALRPRLSCFHQLLLEPPKLEPLQMTWGMLAPPLGNTRLHVVKLLASALS 367
Cdd:pfam04499 159 LLYT------TLEEHPPSDRDPIYLGH-LLRAFSPHLPDFHQLLLDPPKDSPLQTTLGVLIEPLGFERFKIVELIAELLH 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563799 368 ANDAALTHE---------LLALDVPNTMLDLFFHYVFNNFLHAQVEGCVSTMLSlgpppdSSPETPIQNPVVKHLLQQCR 438
Cdd:pfam04499 232 CSNMSLLNEkkgeklkikLVDLGIIPTILDLFFKYPWNNFLHNVVEDIIQQILN------GPMDFSYNSFLVVDLFTDCN 305

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563799 439 LVERILTSWEENDRVQCAGGPRKGYMGHLTRVAGALVQNTEKGPNAEQLRQLLKELpseQQEQWEAFVSGPLAETNKKNM 518
Cdd:pfam04499 306 LTQRILEGQKESDRFQAEKGPRLGYMGHLTLIAEEVVKFSEKYPPELISPDILEIL---ENEEWEEYVEETLEETRERYN 382


                  .
gi 2462563799 519 V 519
Cdd:pfam04499 383 V 383
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 688-879 1.14e-07

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 56.10  E-value: 1.14e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563799  688 GCAARGGATPLSYPSPGPQPPGPSWTATFDPVPTDAPTSPRvsgEEELHTGPPAPQGPLSVPQGLPTQSLA-SPPARDAL 766
Cdd:PHA03247  2671 GRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPA---PHALVSATPLPPGPAAARQASPALPAApAPPAVPAG 2747

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563799  767 QLRSQDPTPPSAPQEATEGSKVTEPSAPC---QALVSIGDLQATFHGIRSAPSSSDSAtrDPSTSVPASGAHQPPQTTEG 843
Cdd:PHA03247  2748 PATPGGPARPARPPTTAGPPAPAPPAAPAagpPRRLTRPAVASLSESRESLPSPWDPA--DPPAAVLAPAAALPPAASPA 2825

                          170       180       190
                   ....*....|....*....|....*....|....*.
gi 2462563799  844 EKSPEPLGlpQSQSAQALTPPPIPNGSAPEGPASPG 879
Cdd:PHA03247  2826 GPLPPPTS--AQPTAPPPPPGPPPPSLPLGGSVAPG 2859
 
Name Accession Description Interval E-value
SAPS pfam04499
SIT4 phosphatase-associated protein; This family includes a conserved region from a group of ...
 128-519 6.98e-152

SIT4 phosphatase-associated protein; This family includes a conserved region from a group of yeast proteins that associate with the SIT4 phosphatase. This association is required for SIT4's role in G1 cyclin transcription and for bud formation. This family also includes homologous regions from other eukaryotes.


Pssm-ID: 398279  Cd Length: 383  Bit Score: 451.69  E-value: 6.98e-152
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563799 128 MGILINRKTDQLVSFLRKKDDFVDLLLQHIGTSAIMDLLLRLLTCVErPQLRQDVVNWLNEEKIVQRLIEQIHPSKDENQ 207
Cdd:pfam04499   1 NENLLDRKTDQMIEFIRKQENFVDKFLKHIDTPAIMDLLLKLISTDK-PELPTGVIEWLNEQNLIPKLLDLLSPSYDEDI 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563799 208 HSNASQSLCDIIRLSREQMIQVQDSPEPDQLLATLEKQETIEQLLSNMFEGeQSQSVIVSGIQVLLTLLEPRRPRSESVT 287
Cdd:pfam04499  80 QSNASDFLKAIITISRNAPLQLQSSIGPNELTRELVSEESVEKLLDNMLKG-KSGSALVNGVGIIIELIRKNNSDYDPVQ 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563799 288 VNSFfssvdgQLELLAQGALESTVSSVgALHALRPRLSCFHQLLLEPPKLEPLQMTWGMLAPPLGNTRLHVVKLLASALS 367
Cdd:pfam04499 159 LLYT------TLEEHPPSDRDPIYLGH-LLRAFSPHLPDFHQLLLDPPKDSPLQTTLGVLIEPLGFERFKIVELIAELLH 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563799 368 ANDAALTHE---------LLALDVPNTMLDLFFHYVFNNFLHAQVEGCVSTMLSlgpppdSSPETPIQNPVVKHLLQQCR 438
Cdd:pfam04499 232 CSNMSLLNEkkgeklkikLVDLGIIPTILDLFFKYPWNNFLHNVVEDIIQQILN------GPMDFSYNSFLVVDLFTDCN 305

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563799 439 LVERILTSWEENDRVQCAGGPRKGYMGHLTRVAGALVQNTEKGPNAEQLRQLLKELpseQQEQWEAFVSGPLAETNKKNM 518
Cdd:pfam04499 306 LTQRILEGQKESDRFQAEKGPRLGYMGHLTLIAEEVVKFSEKYPPELISPDILEIL---ENEEWEEYVEETLEETRERYN 382


                  .
gi 2462563799 519 V 519
Cdd:pfam04499 383 V 383
PHA03247 PHA03247
large tegument protein UL36; Provisional
 688-879 1.14e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 56.10  E-value: 1.14e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563799  688 GCAARGGATPLSYPSPGPQPPGPSWTATFDPVPTDAPTSPRvsgEEELHTGPPAPQGPLSVPQGLPTQSLA-SPPARDAL 766
Cdd:PHA03247  2671 GRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPA---PHALVSATPLPPGPAAARQASPALPAApAPPAVPAG 2747

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563799  767 QLRSQDPTPPSAPQEATEGSKVTEPSAPC---QALVSIGDLQATFHGIRSAPSSSDSAtrDPSTSVPASGAHQPPQTTEG 843
Cdd:PHA03247  2748 PATPGGPARPARPPTTAGPPAPAPPAAPAagpPRRLTRPAVASLSESRESLPSPWDPA--DPPAAVLAPAAALPPAASPA 2825

                          170       180       190
                   ....*....|....*....|....*....|....*.
gi 2462563799  844 EKSPEPLGlpQSQSAQALTPPPIPNGSAPEGPASPG 879
Cdd:PHA03247  2826 GPLPPPTS--AQPTAPPPPPGPPPPSLPLGGSVAPG 2859
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 719-873 8.39e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 40.14  E-value: 8.39e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563799 719 VPTDAPTSPRVSGEEEL--HTGPPAPQGPLSV-PQGlptQSLASPPARDALQLRSQDPTPPSA--PQEATEGSKVTEPSA 793
Cdd:pfam03154 386 MNSNLPPPPALKPLSSLstHHPPSAHPPPLQLmPQS---QQLPPPPAQPPVLTQSQSLPPPAAshPPTSGLHQVPSQSPF 462

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563799 794 PCQALVSIGDLQAT-FHGIRSAPSSSDSATRDPSTSVPASGAHQPPQTTEGEKSPEPLGLPQSQSAQALTPPPIPNGSAP 872
Cdd:pfam03154 463 PQHPFVPGGPPPITpPSGPPTSTSSAMPGIQPPSSASVSSSGPVPAAVSCPLPPVQIKEEALDEAEEPESPPPPPRSPSP 542


                  .
gi 2462563799 873 E 873
Cdd:pfam03154 543 E 543
 
Name Accession Description Interval E-value
SAPS pfam04499
SIT4 phosphatase-associated protein; This family includes a conserved region from a group of ...
 128-519 6.98e-152

SIT4 phosphatase-associated protein; This family includes a conserved region from a group of yeast proteins that associate with the SIT4 phosphatase. This association is required for SIT4's role in G1 cyclin transcription and for bud formation. This family also includes homologous regions from other eukaryotes.


Pssm-ID: 398279  Cd Length: 383  Bit Score: 451.69  E-value: 6.98e-152
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563799 128 MGILINRKTDQLVSFLRKKDDFVDLLLQHIGTSAIMDLLLRLLTCVErPQLRQDVVNWLNEEKIVQRLIEQIHPSKDENQ 207
Cdd:pfam04499   1 NENLLDRKTDQMIEFIRKQENFVDKFLKHIDTPAIMDLLLKLISTDK-PELPTGVIEWLNEQNLIPKLLDLLSPSYDEDI 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563799 208 HSNASQSLCDIIRLSREQMIQVQDSPEPDQLLATLEKQETIEQLLSNMFEGeQSQSVIVSGIQVLLTLLEPRRPRSESVT 287
Cdd:pfam04499  80 QSNASDFLKAIITISRNAPLQLQSSIGPNELTRELVSEESVEKLLDNMLKG-KSGSALVNGVGIIIELIRKNNSDYDPVQ 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563799 288 VNSFfssvdgQLELLAQGALESTVSSVgALHALRPRLSCFHQLLLEPPKLEPLQMTWGMLAPPLGNTRLHVVKLLASALS 367
Cdd:pfam04499 159 LLYT------TLEEHPPSDRDPIYLGH-LLRAFSPHLPDFHQLLLDPPKDSPLQTTLGVLIEPLGFERFKIVELIAELLH 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563799 368 ANDAALTHE---------LLALDVPNTMLDLFFHYVFNNFLHAQVEGCVSTMLSlgpppdSSPETPIQNPVVKHLLQQCR 438
Cdd:pfam04499 232 CSNMSLLNEkkgeklkikLVDLGIIPTILDLFFKYPWNNFLHNVVEDIIQQILN------GPMDFSYNSFLVVDLFTDCN 305

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563799 439 LVERILTSWEENDRVQCAGGPRKGYMGHLTRVAGALVQNTEKGPNAEQLRQLLKELpseQQEQWEAFVSGPLAETNKKNM 518
Cdd:pfam04499 306 LTQRILEGQKESDRFQAEKGPRLGYMGHLTLIAEEVVKFSEKYPPELISPDILEIL---ENEEWEEYVEETLEETRERYN 382


                  .
gi 2462563799 519 V 519
Cdd:pfam04499 383 V 383
PHA03247 PHA03247
large tegument protein UL36; Provisional
 688-879 1.14e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 56.10  E-value: 1.14e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563799  688 GCAARGGATPLSYPSPGPQPPGPSWTATFDPVPTDAPTSPRvsgEEELHTGPPAPQGPLSVPQGLPTQSLA-SPPARDAL 766
Cdd:PHA03247  2671 GRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPA---PHALVSATPLPPGPAAARQASPALPAApAPPAVPAG 2747

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563799  767 QLRSQDPTPPSAPQEATEGSKVTEPSAPC---QALVSIGDLQATFHGIRSAPSSSDSAtrDPSTSVPASGAHQPPQTTEG 843
Cdd:PHA03247  2748 PATPGGPARPARPPTTAGPPAPAPPAAPAagpPRRLTRPAVASLSESRESLPSPWDPA--DPPAAVLAPAAALPPAASPA 2825

                          170       180       190
                   ....*....|....*....|....*....|....*.
gi 2462563799  844 EKSPEPLGlpQSQSAQALTPPPIPNGSAPEGPASPG 879
Cdd:PHA03247  2826 GPLPPPTS--AQPTAPPPPPGPPPPSLPLGGSVAPG 2859
PHA03247 PHA03247
large tegument protein UL36; Provisional
 688-886 7.46e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 53.40  E-value: 7.46e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563799  688 GCAARGGATPlsypspgpqppgpswTATFDPVPTDAPTSPRVSGEEELHTGPPAPQGPLS-----VPQGLPTQSLASPP- 761
Cdd:PHA03247  2724 GPAAARQASP---------------ALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPApappaAPAAGPPRRLTRPAv 2788

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563799  762 ------------------------ARDALQLRSQDPTPPSAPQEATEGSKVTEPSAPCQALVSIGDLQATFHGI-RSAPS 816
Cdd:PHA03247  2789 aslsesreslpspwdpadppaavlAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVrRRPPS 2868

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462563799  817 SSDSATRDPSTSVPASGAHQPPQTtegeKSPEPLGLPQSQSAQALTPP------PIPNGSAPEGPASPGSHHSLPD 886
Cdd:PHA03247  2869 RSPAAKPAAPARPPVRRLARPAVS----RSTESFALPPDQPERPPQPQappppqPQPQPPPPPQPQPPPPPPPRPQ 2940
PHA03247 PHA03247
large tegument protein UL36; Provisional
 717-878 1.54e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 52.25  E-value: 1.54e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563799  717 DPVPTDAPTSPRVSGEEELHTGPPAPQGPLSVPQGLPTQSLASPPARDALQLRS-------QDPTPPSAPQEATEGSKVT 789
Cdd:PHA03247  2620 DTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAaqassppQRPRRRAARPTVGSLTSLA 2699

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563799  790 EPSAP-------CQALVSIGDLQAtfhGIRSAPSSSDSATRDPSTSVPASGAHQP--------PQTTEGEKSPEPLGLPQ 854
Cdd:PHA03247  2700 DPPPPpptpepaPHALVSATPLPP---GPAAARQASPALPAAPAPPAVPAGPATPggparparPPTTAGPPAPAPPAAPA 2776

                          170       180
                   ....*....|....*....|....
gi 2462563799  855 SQSAQALTPPPIPNgSAPEGPASP 878
Cdd:PHA03247  2777 AGPPRRLTRPAVAS-LSESRESLP 2799
PHA03247 PHA03247
large tegument protein UL36; Provisional
 718-878 1.34e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 49.17  E-value: 1.34e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563799  718 PVPTDAPTSPRVSGEEELHTGPP------APQGPLSVPQGLPTQSLASPPARDALQLRSQDPTPPSAPQEATEGSKVTEP 791
Cdd:PHA03247   257 PPPVVGEGADRAPETARGATGPPpppeaaAPNGAAAPPDGVWGAALAGAPLALPAPPDPPPPAPAGDAEEEDDEDGAMEV 336

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563799  792 SAPC---QALVSIG----------------DLQATFHGIRSA--PSSSDSATRDPSTSVPAS--GAHQPPQTTEGEKS-- 846
Cdd:PHA03247   337 VSPLprpRQHYPLGfpkrrrptwtppssleDLSAGRHHPKRAslPTRKRRSARHAATPFARGpgGDDQTRPAAPVPASvp 416

                          170       180       190
                   ....*....|....*....|....*....|...
gi 2462563799  847 -PEPLGLPQSQSAQALTPPPIPNGSAPEGPASP 878
Cdd:PHA03247   417 tPAPTPVPASAPPPPATPLPSAEPGSDDGPAPP 449
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 718-876 6.01e-05

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 46.90  E-value: 6.01e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563799 718 PVPTDAPTSPRVSGEeelhTGPPAPQGPLSVPQGLPTQSLASPPARDALQLRSQDPTPPSAPQEATEGSKVTEPSAPcqa 797
Cdd:PRK07764  609 PEEAARPAAPAAPAA----PAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAAP--- 681

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462563799 798 lvsigdlqatfhgirsAPSSSDSATRDPSTSVPASGAHQPPQTTEGEKSPEPLGLPQSQSAQALTPPPIPNGSAPEGPA 876
Cdd:PRK07764  682 ----------------PPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPLPPE 744
PHA03378 PHA03378
EBNA-3B; Provisional
 693-877 2.93e-04

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 44.67  E-value: 2.93e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563799 693 GGATPLSYPSPGPQPPGPSWTAT----FDPVPTDAPTSPRVSGEEELHTGPPAPQGPLSVPQGLPTqslaspPARdalql 768
Cdd:PHA03378  647 VFPTPHQPPQVEITPYKPTWTQIghipYQPSPTGANTMLPIQWAPGTMQPPPRAPTPMRPPAAPPG------RAQ----- 715

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563799 769 RSQDPTPPSAPQEATEGSKVTEPSAPCQAlvsigdlqatfhgirSAPSSSDSATRDPSTsvpASGAHQPPQTTEGEKSPE 848
Cdd:PHA03378  716 RPAAATGRARPPAAAPGRARPPAAAPGRA---------------RPPAAAPGRARPPAA---APGRARPPAAAPGAPTPQ 777

                         170       180       190
                  ....*....|....*....|....*....|...
gi 2462563799 849 PL----GLPQSQSAQALTPPPIPNGsapeGPAS 877
Cdd:PHA03378  778 PPpqapPAPQQRPRGAPTPQPPPQA----GPTS 806
PTZ00249 PTZ00249
variable surface protein Vir28; Provisional
 718-863 3.15e-04

variable surface protein Vir28; Provisional


Pssm-ID: 140276 [Multi-domain]  Cd Length: 516  Bit Score: 44.25  E-value: 3.15e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563799 718 PVPTDAPTSPRVSGEEELHTGPPAPQGpLSVPQ--GLP-----TQSLASPPARDALQLRS-QDPTPPSapqeategskVT 789
Cdd:PTZ00249  239 PPKHISFSSPHAHGRPPVETRPPNPVS-VSSPQahGRHpgethTPPLVTVPSSKAHDRNPvQTPTPTS----------VS 307

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462563799 790 EPSAPCQALvsigDLQAtfhGIRSAPSSSDSATRDPST-----SVPASGAHQPPQTTEGEKSPEPLGLPQSQSAQALTP 863
Cdd:PTZ00249  308 GYSSQAKGL----EKQA---GGESERTSSVPSEQFPLPlpvllPLGQSGPLESSESEETDEYAGPKGLPEPELELVELQ 379
PHA03247 PHA03247
large tegument protein UL36; Provisional
 720-879 3.24e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.93  E-value: 3.24e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563799  720 PTDAPTSPR----VSGEEELHT---GPPAPQGPLSVPQGLPTQSLasPPARDAlqlrsqdPTPPsapqEATEGSKVTEPS 792
Cdd:PHA03247  2524 PVGEPVHPRmltwIRGLEELASddaGDPPPPLPPAAPPAAPDRSV--PPPRPA-------PRPS----EPAVTSRARRPD 2590

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563799  793 APCQalvsigdlqatfhgirsapSSSDSATRDPSTSVPASGAHQP-PQTTEGEKSPEPLGLPQSQSAQALTPPPIPNGSA 871
Cdd:PHA03247  2591 APPQ-------------------SARPRAPVDDRGDPRGPAPPSPlPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPER 2651


                   ....*...
gi 2462563799  872 PEGPASPG 879
Cdd:PHA03247  2652 PRDDPAPG 2659
PHA03247 PHA03247
large tegument protein UL36; Provisional
 718-885 3.62e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.54  E-value: 3.62e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563799  718 PVPTdAPTSPRVSGEEElhtgPPAPQGPLSVPQglPTQSLASPPARDALQLRSQDPTPPSAPQEAtegskvtePSAPCQA 797
Cdd:PHA03247  2873 AKPA-APARPPVRRLAR----PAVSRSTESFAL--PPDQPERPPQPQAPPPPQPQPQPPPPPQPQ--------PPPPPPP 2937

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563799  798 LvsigdlqatfhgirsaPSSSDSATRDPSTSVPASGAHQPPQTteGEKSPEPLGLPQSQsaqalTPPPIPNGSAPEGPAS 877
Cdd:PHA03247  2938 R----------------PQPPLAPTTDPAGAGEPSGAVPQPWL--GALVPGRVAVPRFR-----VPQPAPSREAPASSTP 2994


                   ....*...
gi 2462563799  878 PGSHHSLP 885
Cdd:PHA03247  2995 PLTGHSLS 3002
PHA03195 PHA03195
tegument protein VP11/12; Provisional
 742-875 7.08e-04

tegument protein VP11/12; Provisional


Pssm-ID: 177556  Cd Length: 746  Bit Score: 43.46  E-value: 7.08e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563799 742 PQGPLSVPQGLPT----------------QSLASPPaRDALQLRSQDPTPPSAPQEATEGSKVTEPSAPCQALVSIGDLQ 805
Cdd:PHA03195  441 PQGPLPAPPNSKTrgtfrrprpgsvrgsrQLPASPP-SNIVSPRTNPAAEGSTAAKNGQGAETIQVRSSGEFNDCIWYLN 519

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462563799 806 ATFHGIRSAPSSSDSATRD----PSTSVPASgahqPPQTTEGEKSPEPLGLPQSQSAQALTPPPIPNGSAPEGP 875
Cdd:PHA03195  520 GAYPHQRSDSSSSDNSTCSstetQYITLPST----PSPTGEVVYTNPLLGPDEEVDASPQPVDPVSDYSAPKNP 589
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 736-886 1.50e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 42.28  E-value: 1.50e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563799 736 HTGPPAPQGPLSVPQGLPTQSLASPPARDALQLRSQDPTPPSAPQEATEGSkvtepsapcqalvsigdlqatfhgirsAP 815
Cdd:PRK07764  390 GAGAPAAAAPSAAAAAPAAAPAPAAAAPAAAAAPAPAAAPQPAPAPAPAPA---------------------------PP 442

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462563799 816 SSSDSATRDPSTSVPASGAHQPPQTTEGEKSPEPLGLPQSQSAQALTPPPIPNGSAPEGPASPGSHHSLPD 886
Cdd:PRK07764  443 SPAGNAPAGGAPSPPPAAAPSAQPAPAPAAAPEPTAAPAPAPPAAPAPAAAPAAPAAPAAPAGADDAATLR 513
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 723-880 1.77e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 42.08  E-value: 1.77e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563799  723 APTSPRVSGEEELHTGPPAPQGPLSVPQGLPTQSLASPPARDALQLRSQDPTPPSAPQEATEGSKVTEPSAPCQALVSIG 802
Cdd:PHA03307   240 SSSESSGCGWGPENECPLPRPAPITLPTRIWEASGWNGPSSRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSS 319

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563799  803 dlqatfhgirSAPSSSDSATRDPSTSVPASGAHQPPqttegekSPEPLGLPQSQSAQALTPPP----IPNGSAPEGPASP 878
Cdd:PHA03307   320 ----------SSRESSSSSTSSSSESSRGAAVSPGP-------SPSRSPSPSRPPPPADPSSPrkrpRPSRAPSSPAASA 382


                   ..
gi 2462563799  879 GS 880
Cdd:PHA03307   383 GR 384
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
738-885 1.87e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 42.14  E-value: 1.87e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563799 738 GPPAPQGPLSVPQGLPTQSLASPPARDALQLRSQDPTPPSAPQEATEGSKVTEPSAPCQALVSigdlqatfhgiRSAPS- 816
Cdd:PRK07003  366 GAPGGGVPARVAGAVPAPGARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAPPA-----------APAPPa 434

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462563799 817 SSDSATRDPSTSVPASGAHQPPQTTEgEKSPEPLGLPQSQSAQALTPP---PIPNGSAPEGPASPGSHHSLP 885
Cdd:PRK07003  435 TADRGDDAADGDAPVPAKANARASAD-SRCDERDAQPPADSGSASAPAsdaPPDAAFEPAPRAAAPSAATPA 505
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 718-886 2.66e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 41.70  E-value: 2.66e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563799  718 PVPTDAPTSPR----VSGEEELHTGPPAPQGPLSVPQGLPTQSLASPPARDALQLRSQDPTPPSAPQEATEGSKVTEPSA 793
Cdd:PHA03307   161 AVASDAASSRQaalpLSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDSS 240

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563799  794 PCQALVSIGDLQATFHGIRSAPSSSDSATRDPSTSVPASGAHQP--PQTTEGEKSPEPlgLPQSQSAQALTPPPIP---- 867
Cdd:PHA03307   241 SSESSGCGWGPENECPLPRPAPITLPTRIWEASGWNGPSSRPGPasSSSSPRERSPSP--SPSSPGSGPAPSSPRAssss 318

                          170
                   ....*....|....*....
gi 2462563799  868 NGSAPEGPASPGSHHSLPD 886
Cdd:PHA03307   319 SSSRESSSSSTSSSSESSR 337
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
716-879 2.91e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 41.40  E-value: 2.91e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563799 716 FDPVPTDAPTSPRVSGEEELHTGPPAPQGPLSVpqglpTQSLASPPARDAlqlrsqdPTPPSAPQEATEGSKVTEPSAPC 795
Cdd:PRK12323  363 FRPGQSGGGAGPATAAAAPVAQPAPAAAAPAAA-----APAPAAPPAAPA-------AAPAAAAAARAVAAAPARRSPAP 430

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563799 796 QALVSIGDLQATFHGIRSAPSSSDSATRDPSTSVPASGAHQPPQTtegEKSPEPLGLPQSQSAQALTPPPiPNGSAPEGP 875
Cdd:PRK12323  431 EALAAARQASARGPGGAPAPAPAPAAAPAAAARPAAAGPRPVAAA---AAAAPARAAPAAAPAPADDDPP-PWEELPPEF 506


                  ....
gi 2462563799 876 ASPG 879
Cdd:PRK12323  507 ASPA 510
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
713-877 4.77e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 40.60  E-value: 4.77e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563799 713 TATFDPVPTDAPTSPRVSGeeelhtGPPAPQGPLSVPQGLPTQSLAsPPARDAlQLRSQDPTPPSAPQEATEGSKVTEPS 792
Cdd:PRK07003  386 RAAAAVGASAVPAVTAVTG------AAGAALAPKAAAAAAATRAEA-PPAAPA-PPATADRGDDAADGDAPVPAKANARA 457

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563799 793 APCQALVSIGDLQATFHGIRSAPSSSdsaTRDPSTSVPASGAHQP-PQTTEGEKSPEPLGLPQSQSAQALTPPPIPNGSA 871
Cdd:PRK07003  458 SADSRCDERDAQPPADSGSASAPASD---APPDAAFEPAPRAAAPsAATPAAVPDARAPAAASREDAPAAAAPPAPEARP 534


                  ....*.
gi 2462563799 872 PEGPAS 877
Cdd:PRK07003  535 PTPAAA 540
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 712-886 5.66e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 40.35  E-value: 5.66e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563799 712 WTATFDPVPTDAPTSPRVSGEEELHTGPPAPQGPLSVPQGLPTQSLASPPARDALQLRSQDPTPPSAPQEATEGSKVTEP 791
Cdd:PRK07764  621 PAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQ 700

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563799 792 SAPCQALVSIGdlqatfhGIRSAPSSSDSATRDPSTSVPASGAHQPPQTTEGEKSPEPLGLPQSQSAQALTPPPIPNGSA 871
Cdd:PRK07764  701 PAPAPAATPPA-------GQADDPAAQPPQAAQGASAPSPAADDPVPLPPEPDDPPDPAGAPAQPPPPPAPAPAAAPAAA 773

                         170
                  ....*....|....*
gi 2462563799 872 PEGPASPGSHHSLPD 886
Cdd:PRK07764  774 PPPSPPSEEEEMAED 788
PHA03247 PHA03247
large tegument protein UL36; Provisional
 690-794 6.89e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.31  E-value: 6.89e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563799  690 AARGGATPLSYPSPGPQPPGPSWTAtfdPVPTDAPTSPRVsgeeeLHTGPPAPQGPLSVPQGLPTQSLASPPARD--ALQ 767
Cdd:PHA03247   387 SARHAATPFARGPGGDDQTRPAAPV---PASVPTPAPTPV-----PASAPPPPATPLPSAEPGSDDGPAPPPERQppAPA 458

                           90       100
                   ....*....|....*....|....*..
gi 2462563799  768 LRSQDPTPPSAPQEATEGSKVTEPSAP 794
Cdd:PHA03247   459 TEPAPDDPDDATRKALDALRERRPPEP 485
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 720-885 7.04e-03

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 40.06  E-value: 7.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563799 720 PTDaPTSPRVSGEEELHTGPPAPQGPLSVPQGLPTQSLASP--PARDALQLRSQDPTPPSAPQ--EATEGSKVTEPSAPC 795
Cdd:PTZ00449  582 PKD-PKHPKDPEEPKKPKRPRSAQRPTRPKSPKLPELLDIPksPKRPESPKSPKRPPPPQRPSspERPEGPKIIKSPKPP 660

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563799 796 QALVSIGD--LQATFHGirsapSSSDSATRDPSTsVPASGAHQPPQTTEGEKSPEPLGLPQSqsaqalTPPPIPngsaPE 873
Cdd:PTZ00449  661 KSPKPPFDpkFKEKFYD-----DYLDAAAKSKET-KTTVVLDESFESILKETLPETPGTPFT------TPRPLP----PK 724

                         170
                  ....*....|..
gi 2462563799 874 GPASPGSHHSLP 885
Cdd:PTZ00449  725 LPRDEEFPFEPI 736
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 719-873 8.39e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 40.14  E-value: 8.39e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563799 719 VPTDAPTSPRVSGEEEL--HTGPPAPQGPLSV-PQGlptQSLASPPARDALQLRSQDPTPPSA--PQEATEGSKVTEPSA 793
Cdd:pfam03154 386 MNSNLPPPPALKPLSSLstHHPPSAHPPPLQLmPQS---QQLPPPPAQPPVLTQSQSLPPPAAshPPTSGLHQVPSQSPF 462

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462563799 794 PCQALVSIGDLQAT-FHGIRSAPSSSDSATRDPSTSVPASGAHQPPQTTEGEKSPEPLGLPQSQSAQALTPPPIPNGSAP 872
Cdd:pfam03154 463 PQHPFVPGGPPPITpPSGPPTSTSSAMPGIQPPSSASVSSSGPVPAAVSCPLPPVQIKEEALDEAEEPESPPPPPRSPSP 542


                  .
gi 2462563799 873 E 873
Cdd:pfam03154 543 E 543
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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