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Conserved domains on  [gi|2462564891|ref|XP_054176741|]
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striatin-4 isoform X4 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 10077586)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 318-640 1.00e-56

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 193.71  E-value: 1.00e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564891 318 PKFTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQkavtakknaalDVEPIHAFRAHRGPVLAVAMGSNSEYCYSG 397
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLE-----------TGELLRTLKGHTGPVRDVAASADGTYLASG 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564891 398 GADACIHSWKIPDlsmdpydgydpSVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSpaCLCTFPTAsE 477
Cdd:cd00200    70 SSDKTIRLWDLET-----------GECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGK--CLTTLRGH-T 135

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564891 478 HGVpTSVAFTSTEpaHIVASFRSGDTV-LYDMEVGSALLTLEsrGSSGPtqINQVVSHPNQPLTITAHDDRGIRFLDNRT 556
Cdd:cd00200   136 DWV-NSVAFSPDG--TFVASSSQDGTIkLWDLRTGKCVATLT--GHTGE--VNSVAFSPDGEKLLSSSSDGTIKLWDLST 208

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564891 557 GKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNKTCVQEITAhrkkHEEAIHAVACHPSKALIASAGADAL 636
Cdd:cd00200   209 GKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSG----HTNSVTSLAWSPDGKRLASGSADGT 284


                  ....
gi 2462564891 637 AKVF 640
Cdd:cd00200   285 IRIW 288
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 318-640 1.00e-56

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 193.71  E-value: 1.00e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564891 318 PKFTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQkavtakknaalDVEPIHAFRAHRGPVLAVAMGSNSEYCYSG 397
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLE-----------TGELLRTLKGHTGPVRDVAASADGTYLASG 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564891 398 GADACIHSWKIPDlsmdpydgydpSVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSpaCLCTFPTAsE 477
Cdd:cd00200    70 SSDKTIRLWDLET-----------GECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGK--CLTTLRGH-T 135

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564891 478 HGVpTSVAFTSTEpaHIVASFRSGDTV-LYDMEVGSALLTLEsrGSSGPtqINQVVSHPNQPLTITAHDDRGIRFLDNRT 556
Cdd:cd00200   136 DWV-NSVAFSPDG--TFVASSSQDGTIkLWDLRTGKCVATLT--GHTGE--VNSVAFSPDGEKLLSSSSDGTIKLWDLST 208

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564891 557 GKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNKTCVQEITAhrkkHEEAIHAVACHPSKALIASAGADAL 636
Cdd:cd00200   209 GKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSG----HTNSVTSLAWSPDGKRLASGSADGT 284


                  ....
gi 2462564891 637 AKVF 640
Cdd:cd00200   285 IRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
314-639 1.79e-55

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 193.97  E-value: 1.79e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564891 314 KTWNPKFTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAvtakknaaldvEPIHAFRAHRGPVLAVAMGSNSEY 393
Cdd:COG2319   108 ATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATG-----------KLLRTLTGHSGAVTSVAFSPDGKL 176

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564891 394 CYSGGADACIHSWKIPDLSmdpydgydpsvLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSssPACLCTFP 473
Cdd:COG2319   177 LASGSDDGTVRLWDLATGK-----------LLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLAT--GKLLRTLT 243

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564891 474 TASehGVPTSVAFtSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSgptqINQVVSHPNQPLTITAHDDRGIRFLD 553
Cdd:COG2319   244 GHS--GSVRSVAF-SPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGG----VNSVAFSPDGKLLASGSDDGTVRLWD 316

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564891 554 NRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNKTCVQEITAhrkkHEEAIHAVACHPSKALIASAGA 633
Cdd:COG2319   317 LATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTG----HTGAVTSVAFSPDGRTLASGSA 392


                  ....*.
gi 2462564891 634 DALAKV 639
Cdd:COG2319   393 DGTVRL 398
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 421-460 2.57e-11

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 58.48  E-value: 2.57e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 2462564891  421 PSVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWD 460
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
426-460 2.72e-10

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 55.81  E-value: 2.72e-10
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 2462564891 426 HVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWD 460
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 382-608 2.14e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 44.31  E-value: 2.14e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564891 382 VLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPSVLSHVLEGHGDAVWGlafSPTSQRLASCSADGTVRIWDP 461
Cdd:PLN00181  486 VCAIGFDRDGEFFATAGVNKKIKIFECESIIKDGRDIHYPVVELASRSKLSGICWN---SYIKSQVASSNFEGVVQVWDV 562

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564891 462 SSSSpacLCTFPTASEHGVpTSVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQINqvvSHPNQPLTI 541
Cdd:PLN00181  563 ARSQ---LVTEMKEHEKRV-WSIDYSSADPTLLASGSDDGSVKLWSINQGVSIGTIKTKANICCVQFP---SESGRSLAF 635

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462564891 542 TAHDDRgIRFLDNRTGK-PVHSMVAHLDAVTCLA-VDpnGAFLMSGSHDCSLRLWSLD------NKTCVQEITAH 608
Cdd:PLN00181  636 GSADHK-VYYYDLRNPKlPLCTMIGHSKTVSYVRfVD--SSTLVSSSTDNTLKLWDLSmsisgiNETPLHSFMGH 707
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 318-640 1.00e-56

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 193.71  E-value: 1.00e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564891 318 PKFTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQkavtakknaalDVEPIHAFRAHRGPVLAVAMGSNSEYCYSG 397
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLE-----------TGELLRTLKGHTGPVRDVAASADGTYLASG 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564891 398 GADACIHSWKIPDlsmdpydgydpSVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSpaCLCTFPTAsE 477
Cdd:cd00200    70 SSDKTIRLWDLET-----------GECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGK--CLTTLRGH-T 135

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564891 478 HGVpTSVAFTSTEpaHIVASFRSGDTV-LYDMEVGSALLTLEsrGSSGPtqINQVVSHPNQPLTITAHDDRGIRFLDNRT 556
Cdd:cd00200   136 DWV-NSVAFSPDG--TFVASSSQDGTIkLWDLRTGKCVATLT--GHTGE--VNSVAFSPDGEKLLSSSSDGTIKLWDLST 208

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564891 557 GKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNKTCVQEITAhrkkHEEAIHAVACHPSKALIASAGADAL 636
Cdd:cd00200   209 GKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSG----HTNSVTSLAWSPDGKRLASGSADGT 284


                  ....
gi 2462564891 637 AKVF 640
Cdd:cd00200   285 IRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
314-639 1.79e-55

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 193.97  E-value: 1.79e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564891 314 KTWNPKFTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAvtakknaaldvEPIHAFRAHRGPVLAVAMGSNSEY 393
Cdd:COG2319   108 ATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATG-----------KLLRTLTGHSGAVTSVAFSPDGKL 176

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564891 394 CYSGGADACIHSWKIPDLSmdpydgydpsvLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSssPACLCTFP 473
Cdd:COG2319   177 LASGSDDGTVRLWDLATGK-----------LLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLAT--GKLLRTLT 243

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564891 474 TASehGVPTSVAFtSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSgptqINQVVSHPNQPLTITAHDDRGIRFLD 553
Cdd:COG2319   244 GHS--GSVRSVAF-SPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGG----VNSVAFSPDGKLLASGSDDGTVRLWD 316

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564891 554 NRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNKTCVQEITAhrkkHEEAIHAVACHPSKALIASAGA 633
Cdd:COG2319   317 LATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTG----HTGAVTSVAFSPDGRTLASGSA 392


                  ....*.
gi 2462564891 634 DALAKV 639
Cdd:COG2319   393 DGTVRL 398
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 305-595 3.04e-48

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 170.59  E-value: 3.04e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564891 305 LSDSKDAFKKTWN-----PKFTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKavtakknaaldVEPIHAFRAHR 379
Cdd:cd00200    25 ATGSGDGTIKVWDletgeLLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLET-----------GECVRTLTGHT 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564891 380 GPVLAVAMGSNSEYCYSGGADACIHSWKIPDlsmdpydgydpSVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIW 459
Cdd:cd00200    94 SYVSSVAFSPDGRILSSSSRDKTIKVWDVET-----------GKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLW 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564891 460 DPSSSSpaCLCTFpTASEHGVpTSVAFTSTEPAHIVASfrSGDTV-LYDMEVGSALLTLESRGSSgptqINQVVSHPNQP 538
Cdd:cd00200   163 DLRTGK--CVATL-TGHTGEV-NSVAFSPDGEKLLSSS--SDGTIkLWDLSTGKCLGTLRGHENG----VNSVAFSPDGY 232

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462564891 539 LTITAHDDRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWS 595
Cdd:cd00200   233 LLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
305-598 8.70e-44

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 162.00  E-value: 8.70e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564891 305 LSDSKDAFKKTWNPK-----FTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAvtakknaaldvEPIHAFRAHR 379
Cdd:COG2319   136 ASGSADGTVRLWDLAtgkllRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATG-----------KLLRTLTGHT 204

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564891 380 GPVLAVAMGSNSEYCYSGGADACIHSWkipdlsmDPYDGydpsVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIW 459
Cdd:COG2319   205 GAVRSVAFSPDGKLLASGSADGTVRLW-------DLATG----KLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLW 273

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564891 460 DPSSssPACLCTFPTASehGVPTSVAFTSTepAHIVASFRSGDTV-LYDMEVGSALLTLESRGSSgptqINQVVSHPNQP 538
Cdd:COG2319   274 DLAT--GELLRTLTGHS--GGVNSVAFSPD--GKLLASGSDDGTVrLWDLATGKLLRTLTGHTGA----VRSVAFSPDGK 343

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564891 539 LTITAHDDRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDN 598
Cdd:COG2319   344 TLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
320-640 8.25e-41

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 153.53  E-value: 8.25e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564891 320 FTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWnlqkavtakknAALDVEPIHAFRAHRGPVLAVAMGSNSEYCYSGGA 399
Cdd:COG2319    30 LLLLGLAAAVASLAASPDGARLAAGAGDLTLLLL-----------DAAAGALLATLLGHTAAVLSVAFSPDGRLLASASA 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564891 400 DACIHSWKIpdlsmdpydgyDPSVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSssPACLCTFPTASehG 479
Cdd:COG2319    99 DGTVRLWDL-----------ATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLAT--GKLLRTLTGHS--G 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564891 480 VPTSVAFTSTEpaHIVASFRSGDTV-LYDMEVGSALLTLesRGSSGPtqINQVVSHPNQPLTITAHDDRGIRFLDNRTGK 558
Cdd:COG2319   164 AVTSVAFSPDG--KLLASGSDDGTVrLWDLATGKLLRTL--TGHTGA--VRSVAFSPDGKLLASGSADGTVRLWDLATGK 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564891 559 PVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNKTCVQEITAHrkkhEEAIHAVACHPSKALIASAGADALAK 638
Cdd:COG2319   238 LLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGH----SGGVNSVAFSPDGKLLASGSDDGTVR 313


                  ..
gi 2462564891 639 VF 640
Cdd:COG2319   314 LW 315
WD40 COG2319
WD40 repeat [General function prediction only];
439-640 1.86e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 91.13  E-value: 1.86e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564891 439 AFSPTSQRLASCSADGTVRIWDPSSSSPAclctfPTASEHGVPTSVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLE 518
Cdd:COG2319     1 ALSADGAALAAASADLALALLAAALGALL-----LLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLL 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564891 519 SRGSSgptqINQVVSHPNQPLTITAHDDRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDN 598
Cdd:COG2319    76 GHTAA----VLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLAT 151

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 2462564891 599 KTCVQEITAhrkkHEEAIHAVACHPSKALIASAGADALAKVF 640
Cdd:COG2319   152 GKLLRTLTG----HSGAVTSVAFSPDGKLLASGSDDGTVRLW 189
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 421-460 2.57e-11

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 58.48  E-value: 2.57e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 2462564891  421 PSVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWD 460
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
426-460 2.72e-10

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 55.81  E-value: 2.72e-10
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 2462564891 426 HVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWD 460
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 556-595 6.02e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 51.93  E-value: 6.02e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 2462564891  556 TGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWS 595
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
557-595 9.59e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 51.19  E-value: 9.59e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2462564891 557 GKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWS 595
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 315-354 3.79e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 49.62  E-value: 3.79e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 2462564891  315 TWNPKFTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWN 354
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
316-354 6.16e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.18  E-value: 6.16e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2462564891 316 WNPKFTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWN 354
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 382-608 2.14e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 44.31  E-value: 2.14e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564891 382 VLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPSVLSHVLEGHGDAVWGlafSPTSQRLASCSADGTVRIWDP 461
Cdd:PLN00181  486 VCAIGFDRDGEFFATAGVNKKIKIFECESIIKDGRDIHYPVVELASRSKLSGICWN---SYIKSQVASSNFEGVVQVWDV 562

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462564891 462 SSSSpacLCTFPTASEHGVpTSVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQINqvvSHPNQPLTI 541
Cdd:PLN00181  563 ARSQ---LVTEMKEHEKRV-WSIDYSSADPTLLASGSDDGSVKLWSINQGVSIGTIKTKANICCVQFP---SESGRSLAF 635

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462564891 542 TAHDDRgIRFLDNRTGK-PVHSMVAHLDAVTCLA-VDpnGAFLMSGSHDCSLRLWSLD------NKTCVQEITAH 608
Cdd:PLN00181  636 GSADHK-VYYYDLRNPKlPLCTMIGHSKTVSYVRfVD--SSTLVSSSTDNTLKLWDLSmsisgiNETPLHSFMGH 707
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 370-407 7.90e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.29  E-value: 7.90e-04
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2462564891  370 EPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSWK 407
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 557-594 1.08e-03

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 41.60  E-value: 1.08e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 2462564891 557 GKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLW 594
Cdd:pfam20426 114 GRMVQSIRQHKDVVSCVAVTSDGSILATGSYDTTVMVW 151
WD40 pfam00400
WD domain, G-beta repeat;
370-406 2.53e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.78  E-value: 2.53e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 2462564891 370 EPIHAFRAHRGPVLAVAMGSNSEYCYSGGADACIHSW 406
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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