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Conserved domains on  [gi|2462567253|ref|XP_054177901|]
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zinc finger protein 878 isoform X2 [Homo sapiens]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12016853)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

CATH:  3.30.160.60|1.10.287.1360
Gene Ontology:  GO:0003700|GO:0005515|GO:0008270|GO:0003677|GO:0006355|GO:0001217
PubMed:  22803940|8183940|2023909|8183939|10748030|27867147|28765213|11361095|30718982|10940247
SCOP:  4003583|4002243

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 39-80 2.10e-23

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 92.92  E-value: 2.10e-23
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 2462567253  39 SVAFEDVAVNFTQEEWALLDPSQKNLYREVMQETLRNLTSIG 80
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
157-556 2.08e-10

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 63.18  E-value: 2.08e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462567253 157 RAFSYSSSLAIHGRTHTGEKPYEC--KECGKAFRFPSSVRRHERIHSAKKPYEC-KQCGKAFSFPSSVRRHERIHSAKKP 233
Cdd:COG5048    41 DSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLSSSSSNSNDN 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462567253 234 YECKQCGKALSYLVSFQTHMRMHTGERPHKCNICGKAFF-SPSSLKRHEKSHTGEKRykckqcdKAFNCPSSFQYHERTH 312
Cdd:COG5048   121 NLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVnTPQSNSLHPPLPANSLS-------KDPSSNLSLLISSNVS 193

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462567253 313 SGEKPYECTQCRKAFRSVKYLRVHERKHTGEKPYECKLCGKGF-ISSTSFRYHEKTHTGEKPYECKKCVKAFSFV----- 386
Cdd:COG5048   194 TSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSpKSLLSQSPSSLSSSDSSSSASESPRSSLPTAssqss 273

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462567253 387 KDLRIHERTHTG-EKPFECKQCGKTFTSSNSFHYHERT--HTGE--KPYEC--KQCGKAFRSASVLQKHIRTHTGEKPYG 459
Cdd:COG5048   274 SPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAK 353

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462567253 460 CK--QCGKVFRVAS-----QLKMHERTHTGEKPYEC--KQCGKAFISSNSIRYHKRTHTGEKP--YKCKQCGKAFISSNS 528
Cdd:COG5048   354 EKllNSSSKFSPLLnneppQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYN 433

                         410       420
                  ....*....|....*....|....*...
gi 2462567253 529 FLYHERIHTGEKPYECKQCGKAFRSASI 556
Cdd:COG5048   434 LIPHKKIHTNHAPLLCSILKSFRRDLDL 461
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 39-80 2.10e-23

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 92.92  E-value: 2.10e-23
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 2462567253  39 SVAFEDVAVNFTQEEWALLDPSQKNLYREVMQETLRNLTSIG 80
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
40-82 1.28e-20

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 85.34  E-value: 1.28e-20
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 2462567253   40 VAFEDVAVNFTQEEWALLDPSQKNLYREVMQETLRNLTSIGKK 82
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQ 43
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 40-79 3.09e-19

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 81.06  E-value: 3.09e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 2462567253  40 VAFEDVAVNFTQEEWALLDPSQKNLYREVMQETLRNLTSI 79
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
157-556 2.08e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 63.18  E-value: 2.08e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462567253 157 RAFSYSSSLAIHGRTHTGEKPYEC--KECGKAFRFPSSVRRHERIHSAKKPYEC-KQCGKAFSFPSSVRRHERIHSAKKP 233
Cdd:COG5048    41 DSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLSSSSSNSNDN 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462567253 234 YECKQCGKALSYLVSFQTHMRMHTGERPHKCNICGKAFF-SPSSLKRHEKSHTGEKRykckqcdKAFNCPSSFQYHERTH 312
Cdd:COG5048   121 NLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVnTPQSNSLHPPLPANSLS-------KDPSSNLSLLISSNVS 193

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462567253 313 SGEKPYECTQCRKAFRSVKYLRVHERKHTGEKPYECKLCGKGF-ISSTSFRYHEKTHTGEKPYECKKCVKAFSFV----- 386
Cdd:COG5048   194 TSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSpKSLLSQSPSSLSSSDSSSSASESPRSSLPTAssqss 273

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462567253 387 KDLRIHERTHTG-EKPFECKQCGKTFTSSNSFHYHERT--HTGE--KPYEC--KQCGKAFRSASVLQKHIRTHTGEKPYG 459
Cdd:COG5048   274 SPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAK 353

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462567253 460 CK--QCGKVFRVAS-----QLKMHERTHTGEKPYEC--KQCGKAFISSNSIRYHKRTHTGEKP--YKCKQCGKAFISSNS 528
Cdd:COG5048   354 EKllNSSSKFSPLLnneppQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYN 433

                         410       420
                  ....*....|....*....|....*...
gi 2462567253 529 FLYHERIHTGEKPYECKQCGKAFRSASI 556
Cdd:COG5048   434 LIPHKKIHTNHAPLLCSILKSFRRDLDL 461
zf-H2C2_2 pfam13465
Zinc-finger double domain;
276-301 1.27e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.27e-04
                          10        20
                  ....*....|....*....|....*.
gi 2462567253 276 SLKRHEKSHTGEKRYKCKQCDKAFNC 301
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
PRK04860 PRK04860
SprT family zinc-dependent metalloprotease;
205-245 5.01e-03

SprT family zinc-dependent metalloprotease;


Pssm-ID: 179886  Cd Length: 160  Bit Score: 37.97  E-value: 5.01e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 2462567253 205 PYECkQCGkafSFPSSVRRHERIHSAKKPYECKQCGKALSY 245
Cdd:PRK04860  119 PYRC-KCQ---EHQLTVRRHNRVVRGEAVYRCRRCGETLVF 155
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 39-80 2.10e-23

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 92.92  E-value: 2.10e-23
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 2462567253  39 SVAFEDVAVNFTQEEWALLDPSQKNLYREVMQETLRNLTSIG 80
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
40-82 1.28e-20

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 85.34  E-value: 1.28e-20
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 2462567253   40 VAFEDVAVNFTQEEWALLDPSQKNLYREVMQETLRNLTSIGKK 82
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQ 43
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 40-79 3.09e-19

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 81.06  E-value: 3.09e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 2462567253  40 VAFEDVAVNFTQEEWALLDPSQKNLYREVMQETLRNLTSI 79
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
157-556 2.08e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 63.18  E-value: 2.08e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462567253 157 RAFSYSSSLAIHGRTHTGEKPYEC--KECGKAFRFPSSVRRHERIHSAKKPYEC-KQCGKAFSFPSSVRRHERIHSAKKP 233
Cdd:COG5048    41 DSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLSSSSSNSNDN 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462567253 234 YECKQCGKALSYLVSFQTHMRMHTGERPHKCNICGKAFF-SPSSLKRHEKSHTGEKRykckqcdKAFNCPSSFQYHERTH 312
Cdd:COG5048   121 NLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVnTPQSNSLHPPLPANSLS-------KDPSSNLSLLISSNVS 193

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462567253 313 SGEKPYECTQCRKAFRSVKYLRVHERKHTGEKPYECKLCGKGF-ISSTSFRYHEKTHTGEKPYECKKCVKAFSFV----- 386
Cdd:COG5048   194 TSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSpKSLLSQSPSSLSSSDSSSSASESPRSSLPTAssqss 273

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462567253 387 KDLRIHERTHTG-EKPFECKQCGKTFTSSNSFHYHERT--HTGE--KPYEC--KQCGKAFRSASVLQKHIRTHTGEKPYG 459
Cdd:COG5048   274 SPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAK 353

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462567253 460 CK--QCGKVFRVAS-----QLKMHERTHTGEKPYEC--KQCGKAFISSNSIRYHKRTHTGEKP--YKCKQCGKAFISSNS 528
Cdd:COG5048   354 EKllNSSSKFSPLLnneppQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYN 433

                         410       420
                  ....*....|....*....|....*...
gi 2462567253 529 FLYHERIHTGEKPYECKQCGKAFRSASI 556
Cdd:COG5048   434 LIPHKKIHTNHAPLLCSILKSFRRDLDL 461
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
260-566 1.04e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 54.70  E-value: 1.04e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462567253 260 RPHKCNICGKAFFSPSSLKRHEKSHTGEKRYKC--KQCDKAFNCPSSFQYHERTHSGEKPYECTQCRKAFRSVKYLRVHE 337
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462567253 338 RKHTGE-KPYECKLCGKGFISSTSFRYHEKTHTgeKPYECKKCVKAFSFVKDLRIHERTHTGEKPFECKqcgkTFTSSNS 416
Cdd:COG5048   112 SSSSNSnDNNLLSSHSLPPSSRDPQLPDLLSIS--NLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSK----DPSSNLS 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462567253 417 FHYHERTHTGEKPYECKQCGKAFRSASVLQKHIRTHTGEKPYGCKQCGKVF-------RVASQLKMHERTHTGEKPYECK 489
Cdd:COG5048   186 LLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSpksllsqSPSSLSSSDSSSSASESPRSSL 265

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462567253 490 QcGKAFISSNSIRYHKRTHTG-EKPYKCKQCGKAFISSNSFLYHER--IHTGE--KPYEC--KQCGKAFRSASILQKHVR 562
Cdd:COG5048   266 P-TASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHIL 344


                  ....
gi 2462567253 563 THAG 566
Cdd:COG5048   345 LHTS 348
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
201-564 2.07e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.38  E-value: 2.07e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462567253 201 SAKKPYECKQCGKAFSFPSSVRRHERIHSAKKPYECKQCGKALSY--LVSFQTHMRMHTGERPHKCNI-CGKAFFSPSSL 277
Cdd:COG5048    29 NAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFsrPLELSRHLRTHHNNPSDLNSKsLPLSNSKASSS 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462567253 278 KRHEKSHTGEKRYKCKQCDKAFNCPSSFQYHERTHSGEKPYECTQC-RKAFRSVKY---------------------LRV 335
Cdd:COG5048   109 SLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSnslhpplpanslskdpssnlsLLI 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462567253 336 HERKHTGEKPYECKLCGKGFISSTSFRYHEKTHTGEKPYECKKCVKAFSFVKDLRIHERTHTGEKPFECKQCG------K 409
Cdd:COG5048   189 SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPrsslptA 268

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462567253 410 TFTSSNSFHYHERTHTG-EKPYECKQCGKAFRSASVLQKHIRT--HTGE--KPYGC--KQCGKVFRVASQLKMHERTHTG 482
Cdd:COG5048   269 SSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTS 348

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462567253 483 EKPYECK--QCGKAFISSNSIRYHKRT--HTGEKPYKCK-----QCGKAFISSNSFLYHERIHTGEKPYECK--QCGKAF 551
Cdd:COG5048   349 ISPAKEKllNSSSKFSPLLNNEPPQSLqqYKDLKNDKKSetlsnSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSF 428

                         410
                  ....*....|...
gi 2462567253 552 RSASILQKHVRTH 564
Cdd:COG5048   429 NRHYNLIPHKKIH 441
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 482-564 4.74e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 45.86  E-value: 4.74e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462567253 482 GEKPYECK--QCGKAFISSNSIRYHKRT-HTGEKPYKckqcGKAFISSNSFLyherihTGEKPYECKQCGKAFRSASILQ 558
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHMLHgHQNQKLHE----NPSPEKMNIFS------AKDKPYRCEVCDKRYKNLNGLK 415


                  ....*.
gi 2462567253 559 KHvRTH 564
Cdd:COG5189   416 YH-RKH 420
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 342-425 6.10e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 45.48  E-value: 6.10e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462567253 342 GEKPYECKL--CGKGFISSTSFRYHEKT-HTGEKPYECKKCVKAFSFVKDlriherthtgEKPFECKQCGKTFTSSNSFH 418
Cdd:COG5189   346 DGKPYKCPVegCNKKYKNQNGLKYHMLHgHQNQKLHENPSPEKMNIFSAK----------DKPYRCEVCDKRYKNLNGLK 415


                  ....*..
gi 2462567253 419 YHeRTHT 425
Cdd:COG5189   416 YH-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
276-301 1.27e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.27e-04
                          10        20
                  ....*....|....*....|....*.
gi 2462567253 276 SLKRHEKSHTGEKRYKCKQCDKAFNC 301
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
473-497 1.81e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.81e-04
                          10        20
                  ....*....|....*....|....*
gi 2462567253 473 LKMHERTHTGEKPYECKQCGKAFIS 497
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
388-413 3.50e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 3.50e-04
                          10        20
                  ....*....|....*....|....*.
gi 2462567253 388 DLRIHERTHTGEKPFECKQCGKTFTS 413
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
502-525 4.65e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 4.65e-04
                          10        20
                  ....*....|....*....|....
gi 2462567253 502 RYHKRTHTGEKPYKCKQCGKAFIS 525
Cdd:pfam13465   3 KRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
332-357 8.80e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 8.80e-04
                          10        20
                  ....*....|....*....|....*.
gi 2462567253 332 YLRVHERKHTGEKPYECKLCGKGFIS 357
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 398-453 9.29e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.01  E-value: 9.29e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462567253 398 GEKPFECK--QCGKTFTSSNSFHYH---------------ERTHTG----EKPYECKQCGKAFRSASVLQKHiRTHT 453
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHmlhghqnqklhenpsPEKMNIfsakDKPYRCEVCDKRYKNLNGLKYH-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
248-271 9.81e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 9.81e-04
                          10        20
                  ....*....|....*....|....
gi 2462567253 248 SFQTHMRMHTGERPHKCNICGKAF 271
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
420-441 1.79e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.79e-03
                          10        20
                  ....*....|....*....|..
gi 2462567253 420 HERTHTGEKPYECKQCGKAFRS 441
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
532-553 2.01e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.01e-03
                          10        20
                  ....*....|....*....|..
gi 2462567253 532 HERIHTGEKPYECKQCGKAFRS 553
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 426-509 2.42e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.47  E-value: 2.42e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462567253 426 GEKPYECK--QCGKAFRSASVLQKHiRTHTGEKPygckqcgKVFRVASQLKmHERTHTGEKPYECKQCGKAFISSNSIRY 503
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYH-MLHGHQNQ-------KLHENPSPEK-MNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ....*.
gi 2462567253 504 HkRTHT 509
Cdd:COG5189   417 H-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
304-329 3.41e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.41e-03
                          10        20
                  ....*....|....*....|....*.
gi 2462567253 304 SFQYHERTHSGEKPYECTQCRKAFRS 329
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
192-216 4.28e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 4.28e-03
                          10        20
                  ....*....|....*....|....*
gi 2462567253 192 SVRRHERIHSAKKPYECKQCGKAFS 216
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
PRK04860 PRK04860
SprT family zinc-dependent metalloprotease;
205-245 5.01e-03

SprT family zinc-dependent metalloprotease;


Pssm-ID: 179886  Cd Length: 160  Bit Score: 37.97  E-value: 5.01e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 2462567253 205 PYECkQCGkafSFPSSVRRHERIHSAKKPYECKQCGKALSY 245
Cdd:PRK04860  119 PYRC-KCQ---EHQLTVRRHNRVVRGEAVYRCRRCGETLVF 155
zf-H2C2_2 pfam13465
Zinc-finger double domain;
445-467 8.77e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 8.77e-03
                          10        20
                  ....*....|....*....|...
gi 2462567253 445 LQKHIRTHTGEKPYGCKQCGKVF 467
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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