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Conserved domains on  [gi|2462568779|ref|XP_054178643|]
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zinc finger protein 561 isoform X5 [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
164-360 1.95e-09

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.94  E-value: 1.95e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462568779 164 PVKTHKGEKSFECKECGRSFRNSSCLNDHIQIHTG-------IKPHKCTYCGKAFTRSTQLTEHVRT--HTG--IKPYEC 232
Cdd:COG5048   245 PSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDsssekgfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGesLKPFSC 324

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462568779 233 KE--CGQAFAQYSGLSIHIRSHSGKKPYQCK--ECGKAFTT-----STSLIQHTRIHTGEKPYECV--ECGKTFITSSRR 301
Cdd:COG5048   325 PYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPllnnePPQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNL 404

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462568779 302 SKHLKTHSGEKPFVCK--ICGKAFLYSSRLNVHLRTHTGEKPFVCkECGKAFAVSSRLSRH 360
Cdd:COG5048   405 SLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLC-SILKSFRRDLDLSNH 464
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
164-360 1.95e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.94  E-value: 1.95e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462568779 164 PVKTHKGEKSFECKECGRSFRNSSCLNDHIQIHTG-------IKPHKCTYCGKAFTRSTQLTEHVRT--HTG--IKPYEC 232
Cdd:COG5048   245 PSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDsssekgfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGesLKPFSC 324

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462568779 233 KE--CGQAFAQYSGLSIHIRSHSGKKPYQCK--ECGKAFTT-----STSLIQHTRIHTGEKPYECV--ECGKTFITSSRR 301
Cdd:COG5048   325 PYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPllnnePPQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNL 404

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462568779 302 SKHLKTHSGEKPFVCK--ICGKAFLYSSRLNVHLRTHTGEKPFVCkECGKAFAVSSRLSRH 360
Cdd:COG5048   405 SLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLC-SILKSFRRDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
328-352 4.99e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 4.99e-04
                          10        20
                  ....*....|....*....|....*
gi 2462568779 328 RLNVHLRTHTGEKPFVCKECGKAFA 352
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
164-360 1.95e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.94  E-value: 1.95e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462568779 164 PVKTHKGEKSFECKECGRSFRNSSCLNDHIQIHTG-------IKPHKCTYCGKAFTRSTQLTEHVRT--HTG--IKPYEC 232
Cdd:COG5048   245 PSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDsssekgfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGesLKPFSC 324

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462568779 233 KE--CGQAFAQYSGLSIHIRSHSGKKPYQCK--ECGKAFTT-----STSLIQHTRIHTGEKPYECV--ECGKTFITSSRR 301
Cdd:COG5048   325 PYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPllnnePPQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNL 404

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462568779 302 SKHLKTHSGEKPFVCK--ICGKAFLYSSRLNVHLRTHTGEKPFVCkECGKAFAVSSRLSRH 360
Cdd:COG5048   405 SLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLC-SILKSFRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
155-309 8.24e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.85  E-value: 8.24e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462568779 155 FTNFSQLYAPVKTHKGEKSFECKE--CGRSFRNSSCLNDHIQIHTGIKPHKCTYC-------GKAFTRSTQLTEHVRTHT 225
Cdd:COG5048   303 SPLTRHLRSVNHSGESLKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLnssskfsPLLNNEPPQSLQQYKDLK 382

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462568779 226 GIKPYEC--KECGQAFAQYSGLSIHIRSHSGKKPYQCK--ECGKAFTTSTSLIQHTRIHTGEKPYECVECGktfitSSRR 301
Cdd:COG5048   383 NDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILK-----SFRR 457


                  ....*...
gi 2462568779 302 SKHLKTHS 309
Cdd:COG5048   458 DLDLSNHG 465
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
172-253 5.31e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.07  E-value: 5.31e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462568779 172 KSFECKECGRSFRNSSCLNDHIQIHTGIKPHKCTY--CGKAFTRSTQLTEHVRTHTGIKPYECKECGQAFAQYSGLSIHI 249
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111


                  ....
gi 2462568779 250 RSHS 253
Cdd:COG5048   112 SSSS 115
zf-H2C2_2 pfam13465
Zinc-finger double domain;
328-352 4.99e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 4.99e-04
                          10        20
                  ....*....|....*....|....*
gi 2462568779 328 RLNVHLRTHTGEKPFVCKECGKAFA 352
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
228-288 9.95e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.83  E-value: 9.95e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462568779 228 KPYECKECGQAFAQYSGLSIHIRSHSGKKPYQC--KECGKAFTTSTSLIQHTRIHTGEKPYEC 288
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLN 94
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
255-328 1.09e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.83  E-value: 1.09e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462568779 255 KKPYQCKECGKAFTTSTSLIQHTRIHTGEKPYEC--VECGKTFITSSRRSKHLKTHSGEKPFVCKICGKAFLYSSR 328
Cdd:COG5048    31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKAS 106
zf-H2C2_2 pfam13465
Zinc-finger double domain;
245-269 1.44e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.44e-03
                          10        20
                  ....*....|....*....|....*
gi 2462568779 245 LSIHIRSHSGKKPYQCKECGKAFTT 269
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
189-213 1.57e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.57e-03
                          10        20
                  ....*....|....*....|....*
gi 2462568779 189 LNDHIQIHTGIKPHKCTYCGKAFTR 213
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
200-257 1.74e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.06  E-value: 1.74e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462568779 200 KPHKCTYCGKAFTRSTQLTEHVRTHTGIKPYECKECGQAFAQYSG--LSIHIRSHSGKKP 257
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPleLSRHLRTHHNNPS 91
zf-H2C2_2 pfam13465
Zinc-finger double domain;
217-241 1.97e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 1.97e-03
                          10        20
                  ....*....|....*....|....*
gi 2462568779 217 LTEHVRTHTGIKPYECKECGQAFAQ 241
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
272-297 5.87e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 5.87e-03
                          10        20
                  ....*....|....*....|....*.
gi 2462568779 272 SLIQHTRIHTGEKPYECVECGKTFIT 297
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 202-224 6.08e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 33.81  E-value: 6.08e-03
                          10        20
                  ....*....|....*....|...
gi 2462568779 202 HKCTYCGKAFTRSTQLTEHVRTH 224
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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