NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2462580083|ref|XP_054179283|]
View 

leucine-rich repeat transmembrane protein FLRT3 isoform X1 [Homo sapiens]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
61-308 9.48e-23

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 101.16  E-value: 9.48e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580083  61 TTLYLQNNQINNagIPSDLKNLLKVERIYLYHNSLDEFPTNLPKYV--KELHLQENNIRTITyDSLSKIPYLEELHLDDN 138
Cdd:COG4886   116 ESLDLSGNQLTD--LPEELANLTNLKELDLSNNQLTDLPEPLGNLTnlKSLDLSNNQLTDLP-EELGNLTNLKELDLSNN 192

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580083 139 SVSAVSIEegaFRDSNYLRLLFLSRNHLSTIPWGLPR--TIEELRLDDNRISTIssPSLQGLTSLKRLVLDGNLLNNhgl 216
Cdd:COG4886   193 QITDLPEP---LGNLTNLEELDLSGNQLTDLPEPLANltNLETLDLSNNQLTDL--PELGNLTNLEELDLSNNQLTD--- 264

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580083 217 gDKVFFNLVNLTELSLVRNSLTAAPVNLPGTNLRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNLSNLPQGIFDDLDN 296
Cdd:COG4886   265 -LPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALS 343

                         250
                  ....*....|..
gi 2462580083 297 ITQLILRNNPWY 308
Cdd:COG4886   344 LSLLALLTLLLL 355
PCC super family cl28216
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 277-354 3.24e-09

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


The actual alignment was detected with superfamily member TIGR00864:

Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 60.48  E-value: 3.24e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462580083  277 DMSNNNLSNLPQGIFDDLDNITQLILRNNPWYCGCKMKWVRDWLQSLPVKV-NVRGLMCQAPEKVRGMAIkdLNAELFD 354
Cdd:TIGR00864    1 DISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVrQPEAALCAGPGALAGQPL--LGIPLLD 77
LRRNT smart00013
Leucine rich repeat N-terminal domain;
31-61 6.65e-05

Leucine rich repeat N-terminal domain;


:

Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 40.38  E-value: 6.65e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 2462580083   31 CPSVCRCDAGFIYCNDRFLTSIPTGIPEDAT 61
Cdd:smart00013   2 CPAPCNCSGTAVDCSGRGLTEVPLDLPPDTT 32
FN3 super family cl21522
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 413-478 5.97e-04

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


The actual alignment was detected with superfamily member pfam00041:

Pssm-ID: 473895 [Multi-domain]  Cd Length: 85  Bit Score: 38.94  E-value: 5.97e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580083 413 ITVKSVTSDTIHISWKLAL----PMTALRLSWLKLGHSpafGSITETIVTGERSEYLVTALEPDSPYKVC 478
Cdd:pfam00041   6 LTVTDVTSTSLTVSWTPPPdgngPITGYEVEYRPKNSG---EPWNEITVPGTTTSVTLTGLKPGTEYEVR 72
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
61-308 9.48e-23

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 101.16  E-value: 9.48e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580083  61 TTLYLQNNQINNagIPSDLKNLLKVERIYLYHNSLDEFPTNLPKYV--KELHLQENNIRTITyDSLSKIPYLEELHLDDN 138
Cdd:COG4886   116 ESLDLSGNQLTD--LPEELANLTNLKELDLSNNQLTDLPEPLGNLTnlKSLDLSNNQLTDLP-EELGNLTNLKELDLSNN 192

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580083 139 SVSAVSIEegaFRDSNYLRLLFLSRNHLSTIPWGLPR--TIEELRLDDNRISTIssPSLQGLTSLKRLVLDGNLLNNhgl 216
Cdd:COG4886   193 QITDLPEP---LGNLTNLEELDLSGNQLTDLPEPLANltNLETLDLSNNQLTDL--PELGNLTNLEELDLSNNQLTD--- 264

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580083 217 gDKVFFNLVNLTELSLVRNSLTAAPVNLPGTNLRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNLSNLPQGIFDDLDN 296
Cdd:COG4886   265 -LPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALS 343

                         250
                  ....*....|..
gi 2462580083 297 ITQLILRNNPWY 308
Cdd:COG4886   344 LSLLALLTLLLL 355
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
44-306 1.89e-19

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 92.84  E-value: 1.89e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580083  44 CNDRF-LTSIPTGIPEDATTLYLQNNQINNagIPSDLKNLLKveRIYLYHNSLDEFPTNLPKYVKELHLQENNIRTITyd 122
Cdd:PRK15370  184 RLKILgLTTIPACIPEQITTLILDNNELKS--LPENLQGNIK--TLYANSNQLTSIPATLPDTIQEMELSINRITELP-- 257

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580083 123 slSKIPY-LEELHLDDNSVSAV--SIEEGafrdsnyLRLLFLSRNHLSTIPWGLPRTIEELRLDDNRISTISSPSLQGlt 199
Cdd:PRK15370  258 --ERLPSaLQSLDLFHNKISCLpeNLPEE-------LRYLSVYDNSIRTLPAHLPSGITHLNVQSNSLTALPETLPPG-- 326

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580083 200 sLKRLVLDGNLLNNhgLGDKVFFNLVNlteLSLVRNSLTAAPVNLPGTnLRKLYLQDNHINRVPPNAFSYLRQlyrLDMS 279
Cdd:PRK15370  327 -LKTLEAGENALTS--LPASLPPELQV---LDVSKNQITVLPETLPPT-ITTLDVSRNALTNLPENLPAALQI---MQAS 396

                         250       260       270
                  ....*....|....*....|....*....|
gi 2462580083 280 NNNLSNLPQGI---FDDLDNITQLILRNNP 306
Cdd:PRK15370  397 RNNLVRLPESLphfRGEGPQPTRIIVEYNP 426
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 42-230 3.92e-15

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 74.82  E-value: 3.92e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580083  42 IYCNDRFLTSIPT-GIPEDATTLYLQNNQINNagIPsDLKNLLKVERIYLYHNSLDEFP--TNLPKYVKeLHLQENNIRT 118
Cdd:cd21340     7 LYLNDKNITKIDNlSLCKNLKVLYLYDNKITK--IE-NLEFLTNLTHLYLQNNQIEKIEnlENLVNLKK-LYLGGNRISV 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580083 119 ITydSLSKIPYLEELHL-------------DDNSVSAVsieegafrdSNYLRLLFLSRNHLSTIP--WGLPRtIEELRLD 183
Cdd:cd21340    83 VE--GLENLTNLEELHIenqrlppgekltfDPRSLAAL---------SNSLRVLNISGNNIDSLEplAPLRN-LEQLDAS 150

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 2462580083 184 DNRISTIS--SPSLQGLTSLKRLVLDGN-LLNNHGLGDKVFFNLVNLTEL 230
Cdd:cd21340   151 NNQISDLEelLDLLSSWPSLRELDLTGNpVCKKPKYRDKIILASKSLEVL 200
LRR_8 pfam13855
Leucine rich repeat;
247-306 7.98e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 57.92  E-value: 7.98e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580083 247 TNLRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNLSNLPQGIFDDLDNITQLILRNNP 306
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNR 60
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 277-354 3.24e-09

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 60.48  E-value: 3.24e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462580083  277 DMSNNNLSNLPQGIFDDLDNITQLILRNNPWYCGCKMKWVRDWLQSLPVKV-NVRGLMCQAPEKVRGMAIkdLNAELFD 354
Cdd:TIGR00864    1 DISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVrQPEAALCAGPGALAGQPL--LGIPLLD 77
LRRCT smart00082
Leucine rich repeat C-terminal domain;
305-356 4.14e-08

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 49.74  E-value: 4.14e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 2462580083  305 NPWYCGCKMKWVRDWLQSLPVKVNVRGLMCQAPEKVRGmAIKDLNAELFDCK 356
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASPSSLRG-PLLELLHSEFKCP 51
LRRNT smart00013
Leucine rich repeat N-terminal domain;
31-61 6.65e-05

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 40.38  E-value: 6.65e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 2462580083   31 CPSVCRCDAGFIYCNDRFLTSIPTGIPEDAT 61
Cdd:smart00013   2 CPAPCNCSGTAVDCSGRGLTEVPLDLPPDTT 32
fn3 pfam00041
Fibronectin type III domain;
413-478 5.97e-04

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 38.94  E-value: 5.97e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580083 413 ITVKSVTSDTIHISWKLAL----PMTALRLSWLKLGHSpafGSITETIVTGERSEYLVTALEPDSPYKVC 478
Cdd:pfam00041   6 LTVTDVTSTSLTVSWTPPPdgngPITGYEVEYRPKNSG---EPWNEITVPGTTTSVTLTGLKPGTEYEVR 72
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 31-57 1.87e-03

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 36.07  E-value: 1.87e-03
                          10        20
                  ....*....|....*....|....*..
gi 2462580083  31 CPSVCRCDAGFIYCNDRFLTSIPTGIP 57
Cdd:pfam01462   2 CPVPCHCSATVVNCSDRGLTAVPRDLP 28
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 413-477 3.62e-03

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 36.82  E-value: 3.62e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462580083  413 ITVKSVTSDTIHISWKLALP--MTALRLSWlKLGHSPAFGSITETIVTGERSEYLVTALEPDSPYKV 477
Cdd:smart00060   7 LRVTDVTSTSVTLSWEPPPDdgITGYIVGY-RVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEF 72
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
61-308 9.48e-23

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 101.16  E-value: 9.48e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580083  61 TTLYLQNNQINNagIPSDLKNLLKVERIYLYHNSLDEFPTNLPKYV--KELHLQENNIRTITyDSLSKIPYLEELHLDDN 138
Cdd:COG4886   116 ESLDLSGNQLTD--LPEELANLTNLKELDLSNNQLTDLPEPLGNLTnlKSLDLSNNQLTDLP-EELGNLTNLKELDLSNN 192

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580083 139 SVSAVSIEegaFRDSNYLRLLFLSRNHLSTIPWGLPR--TIEELRLDDNRISTIssPSLQGLTSLKRLVLDGNLLNNhgl 216
Cdd:COG4886   193 QITDLPEP---LGNLTNLEELDLSGNQLTDLPEPLANltNLETLDLSNNQLTDL--PELGNLTNLEELDLSNNQLTD--- 264

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580083 217 gDKVFFNLVNLTELSLVRNSLTAAPVNLPGTNLRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNLSNLPQGIFDDLDN 296
Cdd:COG4886   265 -LPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALS 343

                         250
                  ....*....|..
gi 2462580083 297 ITQLILRNNPWY 308
Cdd:COG4886   344 LSLLALLTLLLL 355
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
45-305 1.10e-22

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 101.16  E-value: 1.10e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580083  45 NDRFLTSIPTGIPEDATTLYLQNNQINNAGIPSDLKNLLKVERIYLYHNSLDEFPTNLP--KYVKELHLQENNIRTITyD 122
Cdd:COG4886    75 LLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDLPEELAnlTNLKELDLSNNQLTDLP-E 153

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580083 123 SLSKIPYLEELHLDDNSVSAVSIEegaFRDSNYLRLLFLSRNHLSTIPWGL--PRTIEELRLDDNRISTISSPsLQGLTS 200
Cdd:COG4886   154 PLGNLTNLKSLDLSNNQLTDLPEE---LGNLTNLKELDLSNNQITDLPEPLgnLTNLEELDLSGNQLTDLPEP-LANLTN 229

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580083 201 LKRLVLDGNLLNNhgLGDkvFFNLVNLTELSLVRNSLTAAPVNLPGTNLRKLYLQDNHINRVPPNAFSYLRQLYRLDMSN 280
Cdd:COG4886   230 LETLDLSNNQLTD--LPE--LGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLL 305

                         250       260
                  ....*....|....*....|....*
gi 2462580083 281 NNLSNLPQGIFDDLDNITQLILRNN 305
Cdd:COG4886   306 LLLNLLELLILLLLLTTLLLLLLLL 330
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
49-300 3.04e-21

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 96.54  E-value: 3.04e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580083  49 LTSIPTGIPE--DATTLYLQNNQINNagIPSDLKNLLKVERIYLYHNSLDEFPT---NLPKyVKELHLQENNIRTITyDS 123
Cdd:COG4886   125 LTDLPEELANltNLKELDLSNNQLTD--LPEPLGNLTNLKSLDLSNNQLTDLPEelgNLTN-LKELDLSNNQITDLP-EP 200

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580083 124 LSKIPYLEELHLDDNSVSAVSIEegaFRDSNYLRLLFLSRNHLSTIPW--GLPRtIEELRLDDNRISTIssPSLQGLTSL 201
Cdd:COG4886   201 LGNLTNLEELDLSGNQLTDLPEP---LANLTNLETLDLSNNQLTDLPElgNLTN-LEELDLSNNQLTDL--PPLANLTNL 274

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580083 202 KRLVLDGNLLNNHGLgdKVFFNLVNLTELSLVRNSLTAAPVNLPGTNLRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNN 281
Cdd:COG4886   275 KTLDLSNNQLTDLKL--KELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTL 352

                         250
                  ....*....|....*....
gi 2462580083 282 NLSNLPQGIFDDLDNITQL 300
Cdd:COG4886   353 LLLLNLLSLLLTLLLTLGL 371
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
44-306 1.89e-19

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 92.84  E-value: 1.89e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580083  44 CNDRF-LTSIPTGIPEDATTLYLQNNQINNagIPSDLKNLLKveRIYLYHNSLDEFPTNLPKYVKELHLQENNIRTITyd 122
Cdd:PRK15370  184 RLKILgLTTIPACIPEQITTLILDNNELKS--LPENLQGNIK--TLYANSNQLTSIPATLPDTIQEMELSINRITELP-- 257

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580083 123 slSKIPY-LEELHLDDNSVSAV--SIEEGafrdsnyLRLLFLSRNHLSTIPWGLPRTIEELRLDDNRISTISSPSLQGlt 199
Cdd:PRK15370  258 --ERLPSaLQSLDLFHNKISCLpeNLPEE-------LRYLSVYDNSIRTLPAHLPSGITHLNVQSNSLTALPETLPPG-- 326

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580083 200 sLKRLVLDGNLLNNhgLGDKVFFNLVNlteLSLVRNSLTAAPVNLPGTnLRKLYLQDNHINRVPPNAFSYLRQlyrLDMS 279
Cdd:PRK15370  327 -LKTLEAGENALTS--LPASLPPELQV---LDVSKNQITVLPETLPPT-ITTLDVSRNALTNLPENLPAALQI---MQAS 396

                         250       260       270
                  ....*....|....*....|....*....|
gi 2462580083 280 NNNLSNLPQGI---FDDLDNITQLILRNNP 306
Cdd:PRK15370  397 RNNLVRLPESLphfRGEGPQPTRIIVEYNP 426
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 42-230 3.92e-15

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 74.82  E-value: 3.92e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580083  42 IYCNDRFLTSIPT-GIPEDATTLYLQNNQINNagIPsDLKNLLKVERIYLYHNSLDEFP--TNLPKYVKeLHLQENNIRT 118
Cdd:cd21340     7 LYLNDKNITKIDNlSLCKNLKVLYLYDNKITK--IE-NLEFLTNLTHLYLQNNQIEKIEnlENLVNLKK-LYLGGNRISV 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580083 119 ITydSLSKIPYLEELHL-------------DDNSVSAVsieegafrdSNYLRLLFLSRNHLSTIP--WGLPRtIEELRLD 183
Cdd:cd21340    83 VE--GLENLTNLEELHIenqrlppgekltfDPRSLAAL---------SNSLRVLNISGNNIDSLEplAPLRN-LEQLDAS 150

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 2462580083 184 DNRISTIS--SPSLQGLTSLKRLVLDGN-LLNNHGLGDKVFFNLVNLTEL 230
Cdd:cd21340   151 NNQISDLEelLDLLSSWPSLRELDLTGNpVCKKPKYRDKIILASKSLEVL 200
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 61-241 8.46e-14

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 70.97  E-value: 8.46e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580083  61 TTLYLQNNQINNAGIPSDLKNlLKVerIYLYHNSLDEFPtNLPKYVK--ELHLQENNIRTItyDSLSKIPYLEELHLDDN 138
Cdd:cd21340     5 THLYLNDKNITKIDNLSLCKN-LKV--LYLYDNKITKIE-NLEFLTNltHLYLQNNQIEKI--ENLENLVNLKKLYLGGN 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580083 139 SVSAVsieEGaFRDSNYLRLLFLSRNHLstiPWGL-----PRTIEELR-----LD--DNRISTISspSLQGLTSLKRLVL 206
Cdd:cd21340    79 RISVV---EG-LENLTNLEELHIENQRL---PPGEkltfdPRSLAALSnslrvLNisGNNIDSLE--PLAPLRNLEQLDA 149

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 2462580083 207 DGNLLNNHGLGDKVFFNLVNLTELSLVRNSLTAAP 241
Cdd:cd21340   150 SNNQISDLEELLDLLSSWPSLRELDLTGNPVCKKP 184
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
79-305 9.09e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 73.81  E-value: 9.09e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580083  79 LKNLLKVERIYLYHNSLDEFPTNLPKYVKELHLQENNIRTITYDSLSKIPYLEELHLDDNSVSAVSIEEGAFRDSNYLRL 158
Cdd:COG4886     1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580083 159 LFLSRNHLSTIPWGLPRtIEELRLDDNRistisspSLQGLTSLKRLVLDGNLLNNhgLGDKvFFNLVNLTELSLVRNSLT 238
Cdd:COG4886    81 LLSLLLLGLTDLGDLTN-LTELDLSGNE-------ELSNLTNLESLDLSGNQLTD--LPEE-LANLTNLKELDLSNNQLT 149

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462580083 239 AAPVNLPG-TNLRKLYLQDNHINRVpPNAFSYLRQLYRLDMSNNNLSNLPQGIFdDLDNITQLILRNN 305
Cdd:COG4886   150 DLPEPLGNlTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDLPEPLG-NLTNLEELDLSGN 215
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
123-306 2.20e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 72.66  E-value: 2.20e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580083 123 SLSKIPYLEELHLDDNSVSAVSIEEGAFRDSNYLRLLFLSRNHLSTIPWGLPRTIEELRLDDNRISTISSPSLQGLTSLK 202
Cdd:COG4886    20 LLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLT 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580083 203 RLVLDGNllnnhglgdKVFFNLVNLTELSLVRNSLTAAPVNLPG-TNLRKLYLQDNHINRVPPnAFSYLRQLYRLDMSNN 281
Cdd:COG4886   100 ELDLSGN---------EELSNLTNLESLDLSGNQLTDLPEELANlTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNN 169

                         170       180
                  ....*....|....*....|....*
gi 2462580083 282 NLSNLPQGIfDDLDNITQLILRNNP 306
Cdd:COG4886   170 QLTDLPEEL-GNLTNLKELDLSNNQ 193
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
29-272 1.06e-12

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 71.27  E-value: 1.06e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580083  29 KSCPSVCRCDAGFIYCNDRFLTSIPTGIPEDATTLYLQNNQINN--AGIPSDLKNLLkveriyLYHNSLDEFPTNLPKYV 106
Cdd:PRK15370  212 KSLPENLQGNIKTLYANSNQLTSIPATLPDTIQEMELSINRITElpERLPSALQSLD------LFHNKISCLPENLPEEL 285

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580083 107 KELHLQENNIRTITYDSLSKIpylEELHLDDNSVSAV--SIEEGafrdsnyLRLLFLSRNHLSTIPWGLPRTIEELRLDD 184
Cdd:PRK15370  286 RYLSVYDNSIRTLPAHLPSGI---THLNVQSNSLTALpeTLPPG-------LKTLEAGENALTSLPASLPPELQVLDVSK 355

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580083 185 NRISTIssPSLQGLTslkrlvldgnllnnhglgdkvffnlvnLTELSLVRNSLTAAPVNLPGTnLRKLYLQDNHINRVPP 264
Cdd:PRK15370  356 NQITVL--PETLPPT---------------------------ITTLDVSRNALTNLPENLPAA-LQIMQASRNNLVRLPE 405


                  ....*...
gi 2462580083 265 NAFSYLRQ 272
Cdd:PRK15370  406 SLPHFRGE 413
LRR_8 pfam13855
Leucine rich repeat;
247-306 7.98e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 57.92  E-value: 7.98e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580083 247 TNLRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNLSNLPQGIFDDLDNITQLILRNNP 306
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNR 60
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 106-305 4.00e-10

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 62.94  E-value: 4.00e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580083 106 VKELHLQENNIRTITYDSLSKIPYLEELHLDDNSVSAvSIEEGAFRDSNYLRLLFLSRNHLS-TIPWGLPRTIEELRLDD 184
Cdd:PLN00113   71 VVSIDLSGKNISGKISSAIFRLPYIQTINLSNNQLSG-PIPDDIFTTSSSLRYLNLSNNNFTgSIPRGSIPNLETLDLSN 149

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580083 185 NRISTISSPSLQGLTSLKRLVLDGNLLNNHGLGDkvFFNLVNLTELSLVRNSLTAA-PVNLPGT-NLRKLYLQDNHINRV 262
Cdd:PLN00113  150 NMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIPNS--LTNLTSLEFLTLASNQLVGQiPRELGQMkSLKWIYLGYNNLSGE 227

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 2462580083 263 PPNAFSYLRQLYRLDMSNNNLSNLPQGIFDDLDNITQLILRNN 305
Cdd:PLN00113  228 IPYEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQN 270
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
61-252 2.82e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 59.56  E-value: 2.82e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580083  61 TTLYLQNNQINNagIPSDLKNLLKVERIYLYHNSLDEFP--TNLPKyVKELHLQENNIRTItyDSLSKIPYLEELHLDDN 138
Cdd:COG4886   208 EELDLSGNQLTD--LPEPLANLTNLETLDLSNNQLTDLPelGNLTN-LEELDLSNNQLTDL--PPLANLTNLKTLDLSNN 282

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580083 139 SVSAVSIEEGAFRDSNYLRLLFLSRNHLSTIPWGLPRTIEELRLDDNRISTISSPSLQGLTSLKRLVLDGNLLNNHGLGD 218
Cdd:COG4886   283 QLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLL 362

                         170       180       190
                  ....*....|....*....|....*....|....
gi 2462580083 219 KVFFNLVNLTELSLVRNSLTAAPVNLPGTNLRKL 252
Cdd:COG4886   363 LTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTT 396
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 277-354 3.24e-09

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 60.48  E-value: 3.24e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462580083  277 DMSNNNLSNLPQGIFDDLDNITQLILRNNPWYCGCKMKWVRDWLQSLPVKV-NVRGLMCQAPEKVRGMAIkdLNAELFD 354
Cdd:TIGR00864    1 DISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVrQPEAALCAGPGALAGQPL--LGIPLLD 77
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 120-259 5.38e-09

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 58.14  E-value: 5.38e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580083 120 TYDSLSKIPYLEELHLDDNSV--SAVSIEEGAFRDSNY-LRLLFLSRNHL---STIPWG--LP--RTIEELRLDDNRIST 189
Cdd:cd00116   100 VLESLLRSSSLQELKLNNNGLgdRGLRLLAKGLKDLPPaLEKLVLGRNRLegaSCEALAkaLRanRDLKELNLANNGIGD 179

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580083 190 ISSPSL-QGLTSLKRLVLDGnlLNNHGLGDK-------VFFNLVNLTELSLVRNSLTAAPV-----NLPGTN--LRKLYL 254
Cdd:cd00116   180 AGIRALaEGLKANCNLEVLD--LNNNGLTDEgasalaeTLASLKSLEVLNLGDNNLTDAGAaalasALLSPNisLLTLSL 257


                  ....*
gi 2462580083 255 QDNHI 259
Cdd:cd00116   258 SCNDI 262
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 107-327 7.05e-09

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 57.75  E-value: 7.05e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580083 107 KELHLQENNIR--TITYDSLSKI-------PYLEELHLDDN----SVSAVSIEEGAFRDSNYLRLLFLSRNHLS-TIPWG 172
Cdd:cd00116    21 KLLCLQVLRLEgnTLGEEAAKALasalrpqPSLKELCLSLNetgrIPRGLQSLLQGLTKGCGLQELDLSDNALGpDGCGV 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580083 173 LPR-----TIEELRLDDNRISTISSPSLQ-GLTS----LKRLVLDGNLLNNHGLGD--KVFFNLVNLTELSLVRNSLT-- 238
Cdd:cd00116   101 LESllrssSLQELKLNNNGLGDRGLRLLAkGLKDlppaLEKLVLGRNRLEGASCEAlaKALRANRDLKELNLANNGIGda 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580083 239 AAPVNLPG----TNLRKLYLQDNHINRVPPNA----FSYLRQLYRLDMSNNNLSNLP-QGIFDDLDNITQLILRNNPWYC 309
Cdd:cd00116   181 GIRALAEGlkanCNLEVLDLNNNGLTDEGASAlaetLASLKSLEVLNLGDNNLTDAGaAALASALLSPNISLLTLSLSCN 260

                         250
                  ....*....|....*...
gi 2462580083 310 GCKMKWVRDWLQSLPVKV 327
Cdd:cd00116   261 DITDDGAKDLAEVLAEKE 278
LRRCT smart00082
Leucine rich repeat C-terminal domain;
305-356 4.14e-08

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 49.74  E-value: 4.14e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 2462580083  305 NPWYCGCKMKWVRDWLQSLPVKVNVRGLMCQAPEKVRGmAIKDLNAELFDCK 356
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASPSSLRG-PLLELLHSEFKCP 51
LRR_8 pfam13855
Leucine rich repeat;
226-283 6.08e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.45  E-value: 6.08e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462580083 226 NLTELSLVRNSLTA----APVNLPgtNLRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNL 283
Cdd:pfam13855   2 NLRSLDLSNNRLTSlddgAFKGLS--NLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 75-284 6.53e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 56.01  E-value: 6.53e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580083  75 IPSDLKNLLKVERIYLYHNSLDEfptNLPKyvkelhlqennirtitydSLSKIPYLEELHLDDNSVSAvSIEEGAFRDSN 154
Cdd:PLN00113  252 IPSSLGNLKNLQYLFLYQNKLSG---PIPP------------------SIFSLQKLISLDLSDNSLSG-EIPELVIQLQN 309

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580083 155 yLRLLFLSRNHLS-TIPWG---LPRtIEELRLDDNRISTISSPSLQGLTSLKRLVLDGNLLNnhGLGDKVFFNLVNLTEL 230
Cdd:PLN00113  310 -LEILHLFSNNFTgKIPVAltsLPR-LQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNLT--GEIPEGLCSSGNLFKL 385

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462580083 231 SLVRNSLTAA-PVNLPGTN-LRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNLS 284
Cdd:PLN00113  386 ILFSNSLEGEiPKSLGACRsLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQ 441
LRR_8 pfam13855
Leucine rich repeat;
175-237 1.34e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 48.67  E-value: 1.34e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462580083 175 RTIEELRLDDNRISTISSPSLQGLTSLKRLVLDGNLLNnhGLGDKVFFNLVNLTELSLVRNSL 237
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLT--TLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
128-211 1.89e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 48.29  E-value: 1.89e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580083 128 PYLEELHLDDNSVSavSIEEGAFRDSNYLRLLFLSRNHLSTIPWGlprtieelrlddnristisspSLQGLTSLKRLVLD 207
Cdd:pfam13855   1 PNLRSLDLSNNRLT--SLDDGAFKGLSNLKVLDLSNNLLTTLSPG---------------------AFSGLPSLRYLDLS 57


                  ....
gi 2462580083 208 GNLL 211
Cdd:pfam13855  58 GNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 41-305 7.74e-07

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 52.54  E-value: 7.74e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580083  41 FIYCNdRFLTSIPTGI--PEDATTLYLQNNQINNAgIPSDLKNLLKVERIYLYHNSLD-EFP---TNLPKyVKELHLQEN 114
Cdd:PLN00113  266 FLYQN-KLSGPIPPSIfsLQKLISLDLSDNSLSGE-IPELVIQLQNLEILHLFSNNFTgKIPvalTSLPR-LQVLQLWSN 342

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580083 115 NIRTITYDSLSKIPYLEELHLDDNSVSAvSIEEGAFRDSNYLRLLFLSRNHLSTIPWGLP--RTIEELRLDDNRIS---- 188
Cdd:PLN00113  343 KFSGEIPKNLGKHNNLTVLDLSTNNLTG-EIPEGLCSSGNLFKLILFSNSLEGEIPKSLGacRSLRRVRLQDNSFSgelp 421

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580083 189 ------------TISSPSLQG--------LTSLKRLVLDGNLLNNhGLGDkvFFNLVNLTELSLVRNSLTAAPVNLPGT- 247
Cdd:PLN00113  422 seftklplvyflDISNNNLQGrinsrkwdMPSLQMLSLARNKFFG-GLPD--SFGSKRLENLDLSRNQFSGAVPRKLGSl 498

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462580083 248 -NLRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNLSNLPQGIFDDLDNITQLILRNN 305
Cdd:PLN00113  499 sELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQN 557
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
140-305 1.17e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 51.62  E-value: 1.17e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580083 140 VSAVSIEEGAFRDSNYLRL----------LFLSRNHLSTIPWGLPRTIEELRLDDNRISTISSpSLQGltSLKRLVLDGN 209
Cdd:PRK15370  154 VKEAPAKEAANREEAVQRMrdclknnkteLRLKILGLTTIPACIPEQITTLILDNNELKSLPE-NLQG--NIKTLYANSN 230

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580083 210 LLNN--HGLGDKVffnlvnlTELSLVRNSLTAAPVNLPgTNLRKLYLQDNHINRVPPNAFSYLRQlyrLDMSNNNLSNLP 287
Cdd:PRK15370  231 QLTSipATLPDTI-------QEMELSINRITELPERLP-SALQSLDLFHNKISCLPENLPEELRY---LSVYDNSIRTLP 299

                         170
                  ....*....|....*...
gi 2462580083 288 QGIfddLDNITQLILRNN 305
Cdd:PRK15370  300 AHL---PSGITHLNVQSN 314
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 45-284 2.63e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 50.62  E-value: 2.63e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580083  45 NDRFLTSIPT--GIPEDATTLYLQNNQINNAgIPSDLKNLLKVERIYLYHNSLD-EFPTNLP--KYVKELHLQENNIRTI 119
Cdd:PLN00113  341 SNKFSGEIPKnlGKHNNLTVLDLSTNNLTGE-IPEGLCSSGNLFKLILFSNSLEgEIPKSLGacRSLRRVRLQDNSFSGE 419

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580083 120 TYDSLSKIPYLEELHLDDNSVSAvSIEEGAFrDSNYLRLLFLSRNHLSTipwGLP-----RTIEELRLDDNRISTISSPS 194
Cdd:PLN00113  420 LPSEFTKLPLVYFLDISNNNLQG-RINSRKW-DMPSLQMLSLARNKFFG---GLPdsfgsKRLENLDLSRNQFSGAVPRK 494

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580083 195 LQGLTSLKRLVLDGNLLNNhglgdkvffnlVNLTELSLVRNsltaapvnlpgtnLRKLYLQDNHINRVPPNAFSYLRQLY 274
Cdd:PLN00113  495 LGSLSELMQLKLSENKLSG-----------EIPDELSSCKK-------------LVSLDLSHNQLSGQIPASFSEMPVLS 550

                         250
                  ....*....|
gi 2462580083 275 RLDMSNNNLS 284
Cdd:PLN00113  551 QLDLSQNQLS 560
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 61-259 4.36e-06

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 49.40  E-value: 4.36e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580083  61 TTLYLQNNQINNAG---IPSDLKNLLKVERIYLYHNSLDE-----FPTNL--PKYVKELHLQENNIR----TITYDSLSK 126
Cdd:COG5238   239 TTLDLSNNQIGDEGviaLAEALKNNTTVETLYLSGNQIGAegaiaLAKALqgNTTLTSLDLSVNRIGdegaIALAEGLQG 318

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580083 127 IPYLEELHLDDNSVSAvsieEGAfrdsnylRLLF--LSRNhlstipwglpRTIEELRLDDNRISTISSPSLqgltslkrl 204
Cdd:COG5238   319 NKTLHTLNLAYNGIGA----QGA-------IALAkaLQEN----------TTLHSLDLSDNQIGDEGAIAL--------- 368

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580083 205 vldGNLLNNHGlgdkvffnlvNLTELSLVRNSLTAAPVN-----LPGTNLRKLYLQDNHI 259
Cdd:COG5238   369 ---AKYLEGNT----------TLRELNLGKNNIGKQGAEalidaLQTNRLHTLILDGNLI 415
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 45-305 4.62e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 49.85  E-value: 4.62e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580083  45 NDRFLTSIPTGIPEDATTLYLQNNQINNAgIPSDLKNLLKVERIYLYHNSL-DEFP---TNLPKyVKELHLQENNIRTIT 120
Cdd:PLN00113  127 NNNFTGSIPRGSIPNLETLDLSNNMLSGE-IPNDIGSFSSLKVLDLGGNVLvGKIPnslTNLTS-LEFLTLASNQLVGQI 204

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580083 121 YDSLSKIPYLEELHLDDNSVSA-VSIEEGAFRDSNYLRLLFlsrNHLS-TIPWGLP--RTIEELRLDDNRISTISSPSLQ 196
Cdd:PLN00113  205 PRELGQMKSLKWIYLGYNNLSGeIPYEIGGLTSLNHLDLVY---NNLTgPIPSSLGnlKNLQYLFLYQNKLSGPIPPSIF 281

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580083 197 GLTSLKRLVLDGNLLNnhGLGDKVFFNLVNLTELSLVRNSLTA----APVNLPgtNLRKLYLQDNHINRVPPNAFSYLRQ 272
Cdd:PLN00113  282 SLQKLISLDLSDNSLS--GEIPELVIQLQNLEILHLFSNNFTGkipvALTSLP--RLQVLQLWSNKFSGEIPKNLGKHNN 357

                         250       260       270
                  ....*....|....*....|....*....|....
gi 2462580083 273 LYRLDMSNNNLS-NLPQGIFDDlDNITQLILRNN 305
Cdd:PLN00113  358 LTVLDLSTNNLTgEIPEGLCSS-GNLFKLILFSN 390
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
49-306 7.20e-06

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 49.39  E-value: 7.20e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580083  49 LTSIPTGIPEDATTLYLQNNQINN-AGIPSDLKNLlkveriYLYHNSLDEFPTnLPKYVKELHLQENNIRT--------- 118
Cdd:PRK15387  213 LTTLPDCLPAHITTLVIPDNNLTSlPALPPELRTL------EVSGNQLTSLPV-LPPGLLELSIFSNPLTHlpalpsglc 285

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580083 119 ---ITYDSLSKIPY----LEELHLDDNSVSAVSIEegafrdSNYLRLLFLSRNHLSTIPwGLPRTIEELRLDDNRISTIs 191
Cdd:PRK15387  286 klwIFGNQLTSLPVlppgLQELSVSDNQLASLPAL------PSELCKLWAYNNQLTSLP-TLPSGLQELSVSDNQLASL- 357

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580083 192 sPSLQglTSLKRLVLDGNLLNNHGLGDKvffnlvNLTELSLVRNSLTAAPVnLPgTNLRKLYLQDNHINRVP--PNAfsy 269
Cdd:PRK15387  358 -PTLP--SELYKLWAYNNRLTSLPALPS------GLKELIVSGNRLTSLPV-LP-SELKELMVSGNRLTSLPmlPSG--- 423

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 2462580083 270 lrqLYRLDMSNNNLSNLPQGIFdDLDNITQLILRNNP 306
Cdd:PRK15387  424 ---LLSLSVYRNQLTRLPESLI-HLSSETTVNLEGNP 456
LRR_8 pfam13855
Leucine rich repeat;
106-166 2.74e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.13  E-value: 2.74e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462580083 106 VKELHLQENNIRTITYDSLSKIPYLEELHLDDNSVSavSIEEGAFRDSNYLRLLFLSRNHL 166
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLT--TLSPGAFSGLPSLRYLDLSGNRL 61
LRRNT smart00013
Leucine rich repeat N-terminal domain;
31-61 6.65e-05

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 40.38  E-value: 6.65e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 2462580083   31 CPSVCRCDAGFIYCNDRFLTSIPTGIPEDAT 61
Cdd:smart00013   2 CPAPCNCSGTAVDCSGRGLTEVPLDLPPDTT 32
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 226-305 2.04e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 43.24  E-value: 2.04e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580083 226 NLTELSLVRNSLTAAPVNLPGTNLRKLYLQDNHINRVPpnAFSYLRQLYRLDMSNNNLSNLPQgiFDDLDNITQLILRNN 305
Cdd:cd21340     3 RITHLYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIE--NLEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGN 78
fn3 pfam00041
Fibronectin type III domain;
413-478 5.97e-04

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 38.94  E-value: 5.97e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580083 413 ITVKSVTSDTIHISWKLAL----PMTALRLSWLKLGHSpafGSITETIVTGERSEYLVTALEPDSPYKVC 478
Cdd:pfam00041   6 LTVTDVTSTSLTVSWTPPPdgngPITGYEVEYRPKNSG---EPWNEITVPGTTTSVTLTGLKPGTEYEVR 72
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 31-57 1.87e-03

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 36.07  E-value: 1.87e-03
                          10        20
                  ....*....|....*....|....*..
gi 2462580083  31 CPSVCRCDAGFIYCNDRFLTSIPTGIP 57
Cdd:pfam01462   2 CPVPCHCSATVVNCSDRGLTAVPRDLP 28
LRR_8 pfam13855
Leucine rich repeat;
84-138 3.17e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 36.35  E-value: 3.17e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462580083  84 KVERIYLYHNSL----DEFPTNLPKyVKELHLQENNIRTITYDSLSKIPYLEELHLDDN 138
Cdd:pfam13855   2 NLRSLDLSNNRLtsldDGAFKGLSN-LKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 247-283 3.27e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 35.68  E-value: 3.27e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 2462580083 247 TNLRKLYLQDNHINRVPPnaFSYLRQLYRLDMSNNNL 283
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPP--LAKLPNLETLDLSGNNK 35
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 413-477 3.62e-03

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 36.82  E-value: 3.62e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462580083  413 ITVKSVTSDTIHISWKLALP--MTALRLSWlKLGHSPAFGSITETIVTGERSEYLVTALEPDSPYKV 477
Cdd:smart00060   7 LRVTDVTSTSVTLSWEPPPDdgITGYIVGY-RVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEF 72
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH