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Conserved domains on  [gi|2462583755|ref|XP_054181059|]
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transport and Golgi organization protein 2 homolog isoform X14 [Homo sapiens]

Protein Classification

NRDE family protein( domain architecture ID 100)

NRDE family protein similar to Drosophila melanogaster Tango2 (transport and Golgi organization protein 2), which may play a role in Golgi organization

Gene Ontology:  GO:0009306|GO:0007030
PubMed:  16452979

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TANGO2 super family cl01315
Transport and Golgi organization 2; In eukaryotes this family is predicted to play a role in ...
 60-150 1.40e-35

Transport and Golgi organization 2; In eukaryotes this family is predicted to play a role in protein secretion and Golgi organization. In plants this family includes Swiss:A9X6Y0, which is involved in water permeability in the cuticles of fruit. Swiss:P54797 has been found to be expressed during early embryogenesis in mice. This protein contains a conserved NRDE motif. This gene has been characterized in Drosophila melanogaster and named as transport and Golgi organization 2, hence the name Tango2.


The actual alignment was detected with superfamily member pfam05742:

Pssm-ID: 470157  Cd Length: 255  Bit Score: 123.52  E-value: 1.40e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462583755  60 RLILAANRDEFYSRPSKLADFWGNNNEILSGLDMeEGKEGGTWLGISTRGKLAALTNYLQPQLDWQARGRAQQRetsfat 139
Cdd:pfam05742  15 PLILAANRDEFLNRPTAPAHWWEENPNILGGRDL-EGREGGTWLGITKQGRIAALTNYREPSSGPPDAVGARSR------ 87

                          90
                  ....*....|.
gi 2462583755 140 mgteGSLILSF 150
Cdd:pfam05742  88 ----GLLVNDF 94
 
Name Accession Description Interval E-value
TANGO2 pfam05742
Transport and Golgi organization 2; In eukaryotes this family is predicted to play a role in ...
 60-150 1.40e-35

Transport and Golgi organization 2; In eukaryotes this family is predicted to play a role in protein secretion and Golgi organization. In plants this family includes Swiss:A9X6Y0, which is involved in water permeability in the cuticles of fruit. Swiss:P54797 has been found to be expressed during early embryogenesis in mice. This protein contains a conserved NRDE motif. This gene has been characterized in Drosophila melanogaster and named as transport and Golgi organization 2, hence the name Tango2.


Pssm-ID: 461729  Cd Length: 255  Bit Score: 123.52  E-value: 1.40e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462583755  60 RLILAANRDEFYSRPSKLADFWGNNNEILSGLDMeEGKEGGTWLGISTRGKLAALTNYLQPQLDWQARGRAQQRetsfat 139
Cdd:pfam05742  15 PLILAANRDEFLNRPTAPAHWWEENPNILGGRDL-EGREGGTWLGITKQGRIAALTNYREPSSGPPDAVGARSR------ 87

                          90
                  ....*....|.
gi 2462583755 140 mgteGSLILSF 150
Cdd:pfam05742  88 ----GLLVNDF 94
Tango2 COG3332
Uncharacterized stress-responsive protein, TANGO2 (Transport and Golgi organisation 2) family, ...
 60-128 1.53e-20

Uncharacterized stress-responsive protein, TANGO2 (Transport and Golgi organisation 2) family, contains NRDE motif [General function prediction only];


Pssm-ID: 442561  Cd Length: 257  Bit Score: 84.15  E-value: 1.53e-20
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462583755  60 RLILAANRDEFYSRPSKLADFWGNNNEILSGLDMEegkEGGTWLGISTRGKLAALTNY---LQPQLDWQARG 128
Cdd:COG3332    15 PLVLAANRDEFYARPTAPPARWPDAPGVLAGRDLE---AGGTWLGVNRHGRFAALTNRrdpSGPPAGARSRG 83
 
Name Accession Description Interval E-value
TANGO2 pfam05742
Transport and Golgi organization 2; In eukaryotes this family is predicted to play a role in ...
 60-150 1.40e-35

Transport and Golgi organization 2; In eukaryotes this family is predicted to play a role in protein secretion and Golgi organization. In plants this family includes Swiss:A9X6Y0, which is involved in water permeability in the cuticles of fruit. Swiss:P54797 has been found to be expressed during early embryogenesis in mice. This protein contains a conserved NRDE motif. This gene has been characterized in Drosophila melanogaster and named as transport and Golgi organization 2, hence the name Tango2.


Pssm-ID: 461729  Cd Length: 255  Bit Score: 123.52  E-value: 1.40e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462583755  60 RLILAANRDEFYSRPSKLADFWGNNNEILSGLDMeEGKEGGTWLGISTRGKLAALTNYLQPQLDWQARGRAQQRetsfat 139
Cdd:pfam05742  15 PLILAANRDEFLNRPTAPAHWWEENPNILGGRDL-EGREGGTWLGITKQGRIAALTNYREPSSGPPDAVGARSR------ 87

                          90
                  ....*....|.
gi 2462583755 140 mgteGSLILSF 150
Cdd:pfam05742  88 ----GLLVNDF 94
Tango2 COG3332
Uncharacterized stress-responsive protein, TANGO2 (Transport and Golgi organisation 2) family, ...
 60-128 1.53e-20

Uncharacterized stress-responsive protein, TANGO2 (Transport and Golgi organisation 2) family, contains NRDE motif [General function prediction only];


Pssm-ID: 442561  Cd Length: 257  Bit Score: 84.15  E-value: 1.53e-20
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462583755  60 RLILAANRDEFYSRPSKLADFWGNNNEILSGLDMEegkEGGTWLGISTRGKLAALTNY---LQPQLDWQARG 128
Cdd:COG3332    15 PLVLAANRDEFYARPTAPPARWPDAPGVLAGRDLE---AGGTWLGVNRHGRFAALTNRrdpSGPPAGARSRG 83
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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