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Conserved domains on  [gi|2462631361|ref|XP_054183965|]
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SLIT and NTRK-like protein 2 isoform X1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
66-197 2.01e-16

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 82.67  E-value: 2.01e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462631361  66 QLFLNGNLLTRLyPNEFVNYSNAVTLHLGNNGLQEIRTgAFSGLKTLKRLHLNNNKLEILREDtFLGLESLEYLQADYNY 145
Cdd:COG4886   117 SLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPEE-LGNLTNLKELDLSNNQ 193

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2462631361 146 ISAIEAgAFSKLNKLKVLILNDNLLLSLPSNVFRFVLLTHLDLRGNRLKVMP 197
Cdd:COG4886   194 ITDLPE-PLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP 244
LRR_8 pfam13855
Leucine rich repeat;
399-459 4.93e-14

Leucine rich repeat;


:

Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 67.16  E-value: 4.93e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462631361 399 SSLDLLHLGNNRIAVIQEGAFTNLTSLRRLYLNGNYLEVLYPSMFDGLQSLQYLYLEYNVI 459
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
378-529 4.89e-12

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 68.81  E-value: 4.89e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462631361 378 KKLYLTGNYLQTVYKnDLLEYSSLDLLHLGNNRIAVIQEgAFTNLTSLRRLYLNGNYLEVLyPSMFDGLQSLQYLYLEYN 457
Cdd:COG4886   139 KELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGN 215

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462631361 458 VIKEIkpltfdalinlqllflnnnllrslPDNIFGGTALTRLNLRNNHFSHLPvkgVLDQLPAFIQIDLQEN 529
Cdd:COG4886   216 QLTDL------------------------PEPLANLTNLETLDLSNNQLTDLP---ELGNLTNLEELDLSNN 260
LRRCT smart00082
Leucine rich repeat C-terminal domain;
529-579 1.29e-07

Leucine rich repeat C-terminal domain;


:

Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 48.58  E-value: 1.29e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2462631361  529 NPWDCTCDIMGLKDWTEHANSPVIINEVTCESPAKHAGEILKFLGREAICP 579
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASPSSLRGPLLELLHSEFKCP 51
LRRCT super family cl47026
Leucine rich repeat C-terminal domain;
216-252 2.04e-04

Leucine rich repeat C-terminal domain;


The actual alignment was detected with superfamily member smart00082:

Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 39.72  E-value: 2.04e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 2462631361  216 NPWNCTCDLLPLKAWLDTITVFVG--EIVCETPFRLHGK 252
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDpvDLRCASPSSLRGP 39
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
66-197 2.01e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 82.67  E-value: 2.01e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462631361  66 QLFLNGNLLTRLyPNEFVNYSNAVTLHLGNNGLQEIRTgAFSGLKTLKRLHLNNNKLEILREDtFLGLESLEYLQADYNY 145
Cdd:COG4886   117 SLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPEE-LGNLTNLKELDLSNNQ 193

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2462631361 146 ISAIEAgAFSKLNKLKVLILNDNLLLSLPSNVFRFVLLTHLDLRGNRLKVMP 197
Cdd:COG4886   194 ITDLPE-PLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP 244
LRR_8 pfam13855
Leucine rich repeat;
399-459 4.93e-14

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 67.16  E-value: 4.93e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462631361 399 SSLDLLHLGNNRIAVIQEGAFTNLTSLRRLYLNGNYLEVLYPSMFDGLQSLQYLYLEYNVI 459
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
86-146 3.21e-13

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 64.85  E-value: 3.21e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462631361  86 SNAVTLHLGNNGLQEIRTGAFSGLKTLKRLHLNNNKLEILREDTFLGLESLEYLQADYNYI 146
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
378-529 4.89e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 68.81  E-value: 4.89e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462631361 378 KKLYLTGNYLQTVYKnDLLEYSSLDLLHLGNNRIAVIQEgAFTNLTSLRRLYLNGNYLEVLyPSMFDGLQSLQYLYLEYN 457
Cdd:COG4886   139 KELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGN 215

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462631361 458 VIKEIkpltfdalinlqllflnnnllrslPDNIFGGTALTRLNLRNNHFSHLPvkgVLDQLPAFIQIDLQEN 529
Cdd:COG4886   216 QLTDL------------------------PEPLANLTNLETLDLSNNQLTDLP---ELGNLTNLEELDLSNN 260
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 357-530 1.82e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 58.64  E-value: 1.82e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462631361 357 VNCQERKFTNISDLQPkPTSPKKLYLTGNYLQTVykNDLLEYSSLDLLHLGNNRIAVIqEGaFTNLTSLRRLYLNGNYLE 436
Cdd:cd21340     7 LYLNDKNITKIDNLSL-CKNLKVLYLYDNKITKI--ENLEFLTNLTHLYLQNNQIEKI-EN-LENLVNLKKLYLGGNRIS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462631361 437 VLypSMFDGLQSLQYLYLEYNVIKEIKPLTFDalinlqllflnnnllrslPDNIFG-----------G------------ 493
Cdd:cd21340    82 VV--EGLENLTNLEELHIENQRLPPGEKLTFD------------------PRSLAAlsnslrvlnisGnnidsleplapl 141

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 2462631361 494 TALTRLNLRNNHFSHL-PVKGVLDQLPAFIQIDLQENP 530
Cdd:cd21340   142 RNLEQLDASNNQISDLeELLDLLSSWPSLRELDLTGNP 179
LRRCT smart00082
Leucine rich repeat C-terminal domain;
529-579 1.29e-07

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 48.58  E-value: 1.29e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2462631361  529 NPWDCTCDIMGLKDWTEHANSPVIINEVTCESPAKHAGEILKFLGREAICP 579
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASPSSLRGPLLELLHSEFKCP 51
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 67-260 4.34e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 45.55  E-value: 4.34e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462631361  67 LFLNGNLLTRLyPNeFVNYSNAVTLHLGNNGLQEIRTgaFSGLKTLKRLHLNNNKLEILRedtflGLESLEYLQA----- 141
Cdd:cd21340    29 LYLYDNKITKI-EN-LEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRISVVE-----GLENLTNLEElhien 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462631361 142 -----------DYNYISAIeagafskLNKLKVLILNDNLLLSLpSNVFRFVLLTHLDLRGNRLKVM-PFAGVLEHIGGIM 209
Cdd:cd21340   100 qrlppgekltfDPRSLAAL-------SNSLRVLNISGNNIDSL-EPLAPLRNLEQLDASNNQISDLeELLDLLSSWPSLR 171

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2462631361 210 EIQLEENPwnctcdLLPLKAWLDTITVFVGEIVCetpfrLHGKDVTQLTRQ 260
Cdd:cd21340   172 ELDLTGNP------VCKKPKYRDKIILASKSLEV-----LDGKEITDTERQ 211
LRRCT smart00082
Leucine rich repeat C-terminal domain;
216-252 2.04e-04

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 39.72  E-value: 2.04e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 2462631361  216 NPWNCTCDLLPLKAWLDTITVFVG--EIVCETPFRLHGK 252
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDpvDLRCASPSSLRGP 39
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 64-193 1.14e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 42.53  E-value: 1.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462631361  64 IYQLFLNGNLLTRLYPNEFVNYSNAVTLHLGNNGLQEIRTGAFSGLKTLKRLHLNNNKL--EILREdtfLG-LESLEYLQ 140
Cdd:PLN00113  142 LETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLvgQIPRE---LGqMKSLKWIY 218

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462631361 141 ADYNYISA---IEAGAFSKLNKLKvLILNdNLLLSLPSNVFRFVLLTHLDLRGNRL 193
Cdd:PLN00113  219 LGYNNLSGeipYEIGGLTSLNHLD-LVYN-NLTGPIPSSLGNLKNLQYLFLYQNKL 272
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 380-457 2.42e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 41.76  E-value: 2.42e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462631361 380 LYLTGNYLQTVYKNDLLEYSSLDLLHLGNNRIAVIQEGAFTNLTSLRRLYLNGNYLEVLYPSMFDGLQSLQYLYLEYN 457
Cdd:PLN00113  145 LDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYN 222
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
66-197 2.01e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 82.67  E-value: 2.01e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462631361  66 QLFLNGNLLTRLyPNEFVNYSNAVTLHLGNNGLQEIRTgAFSGLKTLKRLHLNNNKLEILREDtFLGLESLEYLQADYNY 145
Cdd:COG4886   117 SLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPEE-LGNLTNLKELDLSNNQ 193

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2462631361 146 ISAIEAgAFSKLNKLKVLILNDNLLLSLPSNVFRFVLLTHLDLRGNRLKVMP 197
Cdd:COG4886   194 ITDLPE-PLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP 244
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
66-217 2.40e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 82.29  E-value: 2.40e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462631361  66 QLFLNGNLLTRLyPNEFVNYSNAVTLHLGNNGLQEIrTGAFSGLKTLKRLHLNNNKLEILrEDTFLGLESLEYLQADYNY 145
Cdd:COG4886   140 ELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQ 216

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462631361 146 ISAIEAgAFSKLNKLKVLILNDNLLLSLPSnVFRFVLLTHLDLRGNRLKVMPFAGVLEHIGgimEIQLEENP 217
Cdd:COG4886   217 LTDLPE-PLANLTNLETLDLSNNQLTDLPE-LGNLTNLEELDLSNNQLTDLPPLANLTNLK---TLDLSNNQ 283
LRR_8 pfam13855
Leucine rich repeat;
399-459 4.93e-14

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 67.16  E-value: 4.93e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462631361 399 SSLDLLHLGNNRIAVIQEGAFTNLTSLRRLYLNGNYLEVLYPSMFDGLQSLQYLYLEYNVI 459
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
86-146 3.21e-13

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 64.85  E-value: 3.21e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462631361  86 SNAVTLHLGNNGLQEIRTGAFSGLKTLKRLHLNNNKLEILREDTFLGLESLEYLQADYNYI 146
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
378-529 4.89e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 68.81  E-value: 4.89e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462631361 378 KKLYLTGNYLQTVYKnDLLEYSSLDLLHLGNNRIAVIQEgAFTNLTSLRRLYLNGNYLEVLyPSMFDGLQSLQYLYLEYN 457
Cdd:COG4886   139 KELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGN 215

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462631361 458 VIKEIkpltfdalinlqllflnnnllrslPDNIFGGTALTRLNLRNNHFSHLPvkgVLDQLPAFIQIDLQEN 529
Cdd:COG4886   216 QLTDL------------------------PEPLANLTNLETLDLSNNQLTDLP---ELGNLTNLEELDLSNN 260
LRR_8 pfam13855
Leucine rich repeat;
111-170 1.33e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 60.23  E-value: 1.33e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462631361 111 TLKRLHLNNNKLEILREDTFLGLESLEYLQADYNYISAIEAGAFSKLNKLKVLILNDNLL 170
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
358-530 9.38e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 64.95  E-value: 9.38e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462631361 358 NCQERKFTNISDLQPKPTSPKKLYLTGNYLQTVyKNDLLEYSSLDLLHLGNNRIAVIQEgAFTNLTSLRRLYLNGNYLEV 437
Cdd:COG4886   142 DLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQLTD 219

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462631361 438 LyPSMFDGLQSLQYLYLEYNVIKEIkpltfdalinlqllflnnnllrslpDNIFGGTALTRLNLRNNHFSHLPvkgVLDQ 517
Cdd:COG4886   220 L-PEPLANLTNLETLDLSNNQLTDL-------------------------PELGNLTNLEELDLSNNQLTDLP---PLAN 270

                         170
                  ....*....|...
gi 2462631361 518 LPAFIQIDLQENP 530
Cdd:COG4886   271 LTNLKTLDLSNNQ 283
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 357-530 1.82e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 58.64  E-value: 1.82e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462631361 357 VNCQERKFTNISDLQPkPTSPKKLYLTGNYLQTVykNDLLEYSSLDLLHLGNNRIAVIqEGaFTNLTSLRRLYLNGNYLE 436
Cdd:cd21340     7 LYLNDKNITKIDNLSL-CKNLKVLYLYDNKITKI--ENLEFLTNLTHLYLQNNQIEKI-EN-LENLVNLKKLYLGGNRIS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462631361 437 VLypSMFDGLQSLQYLYLEYNVIKEIKPLTFDalinlqllflnnnllrslPDNIFG-----------G------------ 493
Cdd:cd21340    82 VV--EGLENLTNLEELHIENQRLPPGEKLTFD------------------PRSLAAlsnslrvlnisGnnidsleplapl 141

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 2462631361 494 TALTRLNLRNNHFSHL-PVKGVLDQLPAFIQIDLQENP 530
Cdd:cd21340   142 RNLEQLDASNNQISDLeELLDLLSSWPSLRELDLTGNP 179
LRR_8 pfam13855
Leucine rich repeat;
135-193 2.27e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 54.07  E-value: 2.27e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462631361 135 SLEYLQADYNYISAIEAGAFSKLNKLKVLILNDNLLLSLPSNVFR-FVLLTHLDLRGNRL 193
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSgLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
365-527 1.10e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 54.94  E-value: 1.10e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462631361 365 TNISDLqPKPTSP----KKLYLTGNYLQTVyKNDLLEYSSLDLLHLGNNRIAVIqEGAFTNLTSLRRLYLNGNYLEVLyP 440
Cdd:COG4886   169 NQLTDL-PEELGNltnlKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTDL-P 244

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462631361 441 SMFdGLQSLQYLYLEYNVIKEIKPLtfdalinlqllflnnnllrslpdniFGGTALTRLNLRNNHFSHLPVKGVLDQLPA 520
Cdd:COG4886   245 ELG-NLTNLEELDLSNNQLTDLPPL-------------------------ANLTNLKTLDLSNNQLTDLKLKELELLLGL 298


                  ....*..
gi 2462631361 521 FIQIDLQ 527
Cdd:COG4886   299 NSLLLLL 305
LRRCT smart00082
Leucine rich repeat C-terminal domain;
529-579 1.29e-07

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 48.58  E-value: 1.29e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2462631361  529 NPWDCTCDIMGLKDWTEHANSPVIINEVTCESPAKHAGEILKFLGREAICP 579
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASPSSLRGPLLELLHSEFKCP 51
LRR_8 pfam13855
Leucine rich repeat;
423-506 4.17e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.52  E-value: 4.17e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462631361 423 TSLRRLYLNGNYLEVLYPSMFDGLQSLQYLYLEYNVIKEIKPLTFDalinlqllflnnnllrslpdnifGGTALTRLNLR 502
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFS-----------------------GLPSLRYLDLS 57


                  ....
gi 2462631361 503 NNHF 506
Cdd:pfam13855  58 GNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
365-504 9.90e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 52.24  E-value: 9.90e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462631361 365 TNISDLQP---KPTSPKKLYLTGNYLQTVyKNDLLEYSSLDLLHLGNNRIAVIQEgaFTNLTSLRRLYLNGNYLEVLYPS 441
Cdd:COG4886   192 NQITDLPEplgNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPL 268

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462631361 442 MfdGLQSLQYLYLEYNVIKEIKPLTFDALINLQLLFLNNNLLRSLPDNIFGGTALTRLNLRNN 504
Cdd:COG4886   269 A--NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLL 329
LRR_8 pfam13855
Leucine rich repeat;
67-122 5.66e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.44  E-value: 5.66e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462631361  67 LFLNGNLLTRLYPNEFVNYSNAVTLHLGNNGLQEIRTGAFSGLKTLKRLHLNNNKL 122
Cdd:pfam13855   6 LDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 67-260 4.34e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 45.55  E-value: 4.34e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462631361  67 LFLNGNLLTRLyPNeFVNYSNAVTLHLGNNGLQEIRTgaFSGLKTLKRLHLNNNKLEILRedtflGLESLEYLQA----- 141
Cdd:cd21340    29 LYLYDNKITKI-EN-LEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRISVVE-----GLENLTNLEElhien 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462631361 142 -----------DYNYISAIeagafskLNKLKVLILNDNLLLSLpSNVFRFVLLTHLDLRGNRLKVM-PFAGVLEHIGGIM 209
Cdd:cd21340   100 qrlppgekltfDPRSLAAL-------SNSLRVLNISGNNIDSL-EPLAPLRNLEQLDASNNQISDLeELLDLLSSWPSLR 171

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2462631361 210 EIQLEENPwnctcdLLPLKAWLDTITVFVGEIVCetpfrLHGKDVTQLTRQ 260
Cdd:cd21340   172 ELDLTGNP------VCKKPKYRDKIILASKSLEV-----LDGKEITDTERQ 211
LRRCT smart00082
Leucine rich repeat C-terminal domain;
216-252 2.04e-04

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 39.72  E-value: 2.04e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 2462631361  216 NPWNCTCDLLPLKAWLDTITVFVG--EIVCETPFRLHGK 252
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDpvDLRCASPSSLRGP 39
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
40-197 3.50e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 43.77  E-value: 3.50e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462631361  40 NVLNINCENKGFTTVSLLQPPQYRIYQLFLNGNLLTRLYPNEFVNYSNAVTL-HLGNNGLQEIRTGAFSGLKTLKRLHLN 118
Cdd:COG4886     1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLlSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462631361 119 NNKLEILREDTFLGLESLEYLQADYNyisaieaGAFSKLNKLKVLILNDNLLLSLPSNVFRFVLLTHLDLRGNRLKVMP 197
Cdd:COG4886    81 LLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLP 152
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 64-193 1.14e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 42.53  E-value: 1.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462631361  64 IYQLFLNGNLLTRLYPNEFVNYSNAVTLHLGNNGLQEIRTGAFSGLKTLKRLHLNNNKL--EILREdtfLG-LESLEYLQ 140
Cdd:PLN00113  142 LETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLvgQIPRE---LGqMKSLKWIY 218

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462631361 141 ADYNYISA---IEAGAFSKLNKLKvLILNdNLLLSLPSNVFRFVLLTHLDLRGNRL 193
Cdd:PLN00113  219 LGYNNLSGeipYEIGGLTSLNHLD-LVYN-NLTGPIPSSLGNLKNLQYLFLYQNKL 272
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 96-191 2.06e-03

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 39.07  E-value: 2.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462631361  96 NGLQEIRTGAFSGLKTLKRLHLNNNkLEILREDTFLG--LESLEYLqadyNYISAIEAGAFSKLNKLKVLILNDNlLLSL 173
Cdd:pfam13306  20 SSLTSIGEYAFSNCTSLKSITLPSS-LTSIGSYAFYNcsLTSITIP----SSLTSIGEYAFSNCSNLKSITLPSN-LTSI 93

                          90
                  ....*....|....*...
gi 2462631361 174 PSNVFRFVLLTHLDLRGN 191
Cdd:pfam13306  94 GSYAFSNCSLKSITIPSS 111
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 380-457 2.42e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 41.76  E-value: 2.42e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462631361 380 LYLTGNYLQTVYKNDLLEYSSLDLLHLGNNRIAVIQEGAFTNLTSLRRLYLNGNYLEVLYPSMFDGLQSLQYLYLEYN 457
Cdd:PLN00113  145 LDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYN 222
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
338-529 3.74e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 40.69  E-value: 3.74e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462631361 338 LTCPSSCVCTSQSSDNGLNVNCQERKFTNISDLQPKPTSPKKLYLTGNYLQTVYKNDLLEYSSLDLLHLGNNRIAVIQEg 417
Cdd:COG4886    13 LLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTD- 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462631361 418 aFTNLTSLRRLYLNGNylevlypSMFDGLQSLQYLYLEYNVIKEIkpltfdalinlqllflnnnllrslPDNIFGGTALT 497
Cdd:COG4886    92 -LGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDL------------------------PEELANLTNLK 139

                         170       180       190
                  ....*....|....*....|....*....|..
gi 2462631361 498 RLNLRNNHFSHLPVkgVLDQLPAFIQIDLQEN 529
Cdd:COG4886   140 ELDLSNNQLTDLPE--PLGNLTNLKSLDLSNN 169
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 82-217 4.29e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 40.03  E-value: 4.29e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462631361  82 FVNYSNAVTLHLGNNGLQEIRTGAFSGL---KTLKRLHLNNNKLEILREDTFL-GL----ESLEYLQADYNYISAIE--- 150
Cdd:cd00116    77 LTKGCGLQELDLSDNALGPDGCGVLESLlrsSSLQELKLNNNGLGDRGLRLLAkGLkdlpPALEKLVLGRNRLEGAScea 156

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462631361 151 -AGAFSKLNKLKVLILNDN---------LLLSLPSNvfrfVLLTHLDLRGNRLK---VMPFAGVLEHIGGIMEIQLEENP 217
Cdd:cd00116   157 lAKALRANRDLKELNLANNgigdagiraLAEGLKAN----CNLEVLDLNNNGLTdegASALAETLASLKSLEVLNLGDNN 232
PLN03150 PLN03150
hypothetical protein; Provisional
 91-170 4.95e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 40.57  E-value: 4.95e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462631361  91 LHLGNNGLQEIRTGAFSGLKTLKRLHLNNNKLEILREDTFLGLESLEYLQADYNYISAIEAGAFSKLNKLKVLILNDNLL 170
Cdd:PLN03150  423 LGLDNQGLRGFIPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSL 502
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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