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Conserved domains on  [gi|2462492653|ref|XP_054185911|]
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mediator of DNA damage checkpoint protein 1 isoform X3 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
BRCT_MDC1_rpt2 cd18441
second BRCT domain of mediator of DNA damage checkpoint protein 1 (MDC1) and similar proteins; ...
1995-2075 1.86e-43

second BRCT domain of mediator of DNA damage checkpoint protein 1 (MDC1) and similar proteins; MDC1, also termed nuclear factor with BRCT domains 1 (NFBD1), is a nuclear chromatin-associated protein that is required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle. It directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks. MDC1 contains a forkhead-associated (FHA) domain and two BRCT domains, as well as an internal 41-amino acid repeat sequence. The family corresponds to the second BRCT domain. The Trp-X-X-X-Cys/Ser signature motif of the BRCT family is not conserved in this family.


:

Pssm-ID: 349394  Cd Length: 81  Bit Score: 152.92  E-value: 1.86e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1995 LLEGYEIYVTPGVQPPPPQMGEIISCCGGTYLPSMPRSYKPQRVVITCPQDFPHCSIPLRVGLPLLSPEFLLTGVLKQEA 2074
Cdd:cd18441      1 LLEGYEIHVTPGVKPEPPQMKDIITCAGGTFLPSMPKTYKPQTVVISCPEDFPHCSPALKAGLPVVSAEFLLTGILRQEA 80

                   .
gi 2462492653 2075 K 2075
Cdd:cd18441     81 D 81
FHA_MDC1 cd22665
forkhead associated (FHA) domain found in mediator of DNA damage checkpoint protein 1 (MDC1) ...
32-131 1.12e-37

forkhead associated (FHA) domain found in mediator of DNA damage checkpoint protein 1 (MDC1) and similar proteins; MDC1, also called nuclear factor with BRCT domains 1 (NFBD1), is a nuclear chromatin-associated protein that is required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S and G2/M phases of the cell cycle. It directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks. MDC1 contains a forkhead-associated (FHA) domain and two BRCT domains, as well as an internal 41-amino acid repeat sequence. The FHA domain is a small phosphopeptide recognition module.


:

Pssm-ID: 438717 [Multi-domain]  Cd Length: 97  Bit Score: 136.98  E-value: 1.12e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653   32 GRLHIFSGAHGPEKDFPLHLGKNVVGRMPDCSVALPFPSISKQHAEIEILAwdKAPILRDCGSLNGTQIlRPPKVLSPGV 111
Cdd:cd22665      1 GRLKVFSQAHGPEKDFPLYEGENVIGRDPSCSVVLPDKSVSKQHACIEVDG--GTHLIEDLGSTNGTRI-GNKVRLKPNV 77
                           90       100
                   ....*....|....*....|
gi 2462492653  112 SHRLRDQELILFADLLCQYH 131
Cdd:cd22665     78 RYELIDGDLLLFGDVKCQYV 97
BRCT_MDC1_rpt1 cd17744
first BRCT domain of mediator of DNA damage checkpoint protein 1 (MDC1) and similar proteins; ...
1893-1963 2.10e-27

first BRCT domain of mediator of DNA damage checkpoint protein 1 (MDC1) and similar proteins; MDC1, also termed nuclear factor with BRCT domains 1 (NFBD1), is a nuclear chromatin-associated protein that is required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle. It directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks. MDC1 contains a forkhead-associated (FHA) domain and two BRCT domains, as well as an internal 41-amino acid repeat sequence. The family corresponds to the first BRCT domain.


:

Pssm-ID: 349375 [Multi-domain]  Cd Length: 72  Bit Score: 106.93  E-value: 2.10e-27
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462492653 1893 PKVLFTGVVD-ARGERAVLALGGSLAGSAAEASHLVTDRIRRTVKFLCALGRGIPILSLDWLHQSRKAGFFL 1963
Cdd:cd17744      1 PRVLFTGVSDkEEGEKIIKKLGGSVVDSVEDCTHLVTDKVRRTVKFLCALARGIPIVSPDWLEASIKANKFL 72
PHA03247 super family cl33720
large tegument protein UL36; Provisional
1227-1757 1.68e-17

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 90.00  E-value: 1.68e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1227 ATRGRKNRSSVKTPEPVVPTAP-ELQPSTSTDQPVtSEPTYQAT----RGRKNRSSVKTPEPVVPTAPELRPSTsTDRPV 1301
Cdd:PHA03247  2491 AAGAAPDPGGGGPPDPDAPPAPsRLAPAILPDEPV-GEPVHPRMltwiRGLEELASDDAGDPPPPLPPAAPPAA-PDRSV 2568
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1302 -TPKPTSRttrsrtnmssvktpetvvPTAPELQiSTSTDQPVTPKPTsrttRSRTNMSSVKNPESTVPIAPeLPPSTSTE 1380
Cdd:PHA03247  2569 pPPRPAPR------------------PSEPAVT-SRARRPDAPPQSA----RPRAPVDDRGDPRGPAPPSP-LPPDTHAP 2624
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1381 QPVTPEPTSRATRGRKNRSSGKTP---ETLVPTAPKLEPSTSTDQPVTPEPTSQATRGRTNRSSvktPETVVPTAPELQP 1457
Cdd:PHA03247  2625 DPPPPSPSPAANEPDPHPPPTVPPperPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAA---RPTVGSLTSLADP 2701
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1458 StstDQPVTPEPTSQATrgrtdrsSVKTPETVVPTAPELQASASTDQPVTSEPTSRTTRGRKNRSSVKTPETVVPAAPEL 1537
Cdd:PHA03247  2702 P---PPPPTPEPAPHAL-------VSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAP 2771
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1538 QPSTSTDQPVTPEPTSRATRGRTNRSSVKTPESIVPIAPELQPSTSRNQLVTPEPTSRATRCRTNRSSVKTPEPVVPTAP 1617
Cdd:PHA03247  2772 PAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLP 2851
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1618 -----EPHPTTSTDQPVTPKLTSRATRRKTNRSSVKTPKPVEPAASDLEPFTPTDQSVTPEAIAQGGQSKTLRSSTVRAM 1692
Cdd:PHA03247  2852 lggsvAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQP 2931
                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462492653 1693 PVPTTPEFQSPVTTDQPISPEPITQPSCIKRQRAAGNPGSLAAPIDHKPCSAPLEPKSQASRNQR 1757
Cdd:PHA03247  2932 PPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASSTPPL 2996
PTZ00449 super family cl33186
104 kDa microneme/rhoptry antigen; Provisional
943-1376 1.01e-06

104 kDa microneme/rhoptry antigen; Provisional


The actual alignment was detected with superfamily member PTZ00449:

Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 54.31  E-value: 1.01e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653  943 ERDTQRGEPEGGSQDQKgQASSPTPEPGVGAGDLPGPTSAPVPS-----GSQSGGRGSPVSPRRHQ-----KGLLNCKMP 1012
Cdd:PTZ00449   528 EGEEGEHEDSKESDEPK-EGGKPGETKEGEVGKKPGPAKEHKPSkiptlSKKPEFPKDPKHPKDPEepkkpKRPRSAQRP 606
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1013 PAEKASRIRAAEKVSRgdqeSPDACLPPTVPEAPAPPQKPLNSQsqkhlapppllspllpsiKPtvrktrqdgsqEAPEA 1092
Cdd:PTZ00449   607 TRPKSPKLPELLDIPK----SPKRPESPKSPKRPPPPQRPSSPE------------------RP-----------EGPKI 653
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1093 PLSSElEPFHPKPKIRTRKSSRMTPFPATSAAPEPHPSTSTAQPVTPKPTSQATRSRTNRSSVKTPEPVVPTAPelqpst 1172
Cdd:PTZ00449   654 IKSPK-PPKSPKPPFDPKFKEKFYDDYLDAAAKSKETKTTVVLDESFESILKETLPETPGTPFTTPRPLPPKLP------ 726
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1173 sTDQPVTSEPTSQVTRGRKSRSSVKTPETVVPTALELQPSTSTDRPVTSEPTsqatrgRKNRSSVKTPEPVVPTAPELQP 1252
Cdd:PTZ00449   727 -RDEEFPFEPIGDPDAEQPDDIEFFTPPEEERTFFHETPADTPLPDILAEEF------KEEDIHAETGEPDEAMKRPDSP 799
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1253 STSTDQPVTSEPTYQATRGRKNRSSVKTPEpvVPTAPELRPSTSTDRPVTPKptsrTTRSRTNMSSVKTPETVVPTAPEL 1332
Cdd:PTZ00449   800 SEHEDKPPGDHPSLPKKRHRLDGLALSTTD--LESDAGRIAKDASGKIVKLK----RSKSFDDLTTVEEAEEMGAEARKI 873
                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2462492653 1333 QIS---TSTD----QPVTPKPTSRTTRSRTNMSSVKNPESTVPIAPELPPS 1376
Cdd:PTZ00449   874 VVDddgTEADdedtHPPEEKHKSEVRRRRPPKKPSKPKKPSKPKKPKKPDS 924
SMC_N super family cl47134
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
822-962 3.46e-03

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


The actual alignment was detected with superfamily member TIGR02169:

Pssm-ID: 481474 [Multi-domain]  Cd Length: 1164  Bit Score: 42.75  E-value: 3.46e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653  822 ERVGPERGPLERETEKL-----LPERQTDVTGEEELTKGKQDREQKQLLARDTQRQE----------SDKNGESASPERD 886
Cdd:TIGR02169  194 DEKRQQLERLRREREKAeryqaLLKEKREYEGYELLKEKEALERQKEAIERQLASLEeeleklteeiSELEKRLEEIEQL 273
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462492653  887 RESLKVEIETSEEIQEKQVQKQTLPSKAFEREVERPVANRECDPAELEEKVPKVILERDTQRGEPEGGSQDQKGQA 962
Cdd:TIGR02169  274 LEELNKKIKDLGEEEQLRVKEKIGELEAEIASLERSIAEKERELEDAEERLAKLEAEIDKLLAEIEELEREIEEER 349
 
Name Accession Description Interval E-value
BRCT_MDC1_rpt2 cd18441
second BRCT domain of mediator of DNA damage checkpoint protein 1 (MDC1) and similar proteins; ...
1995-2075 1.86e-43

second BRCT domain of mediator of DNA damage checkpoint protein 1 (MDC1) and similar proteins; MDC1, also termed nuclear factor with BRCT domains 1 (NFBD1), is a nuclear chromatin-associated protein that is required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle. It directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks. MDC1 contains a forkhead-associated (FHA) domain and two BRCT domains, as well as an internal 41-amino acid repeat sequence. The family corresponds to the second BRCT domain. The Trp-X-X-X-Cys/Ser signature motif of the BRCT family is not conserved in this family.


Pssm-ID: 349394  Cd Length: 81  Bit Score: 152.92  E-value: 1.86e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1995 LLEGYEIYVTPGVQPPPPQMGEIISCCGGTYLPSMPRSYKPQRVVITCPQDFPHCSIPLRVGLPLLSPEFLLTGVLKQEA 2074
Cdd:cd18441      1 LLEGYEIHVTPGVKPEPPQMKDIITCAGGTFLPSMPKTYKPQTVVISCPEDFPHCSPALKAGLPVVSAEFLLTGILRQEA 80

                   .
gi 2462492653 2075 K 2075
Cdd:cd18441     81 D 81
FHA_MDC1 cd22665
forkhead associated (FHA) domain found in mediator of DNA damage checkpoint protein 1 (MDC1) ...
32-131 1.12e-37

forkhead associated (FHA) domain found in mediator of DNA damage checkpoint protein 1 (MDC1) and similar proteins; MDC1, also called nuclear factor with BRCT domains 1 (NFBD1), is a nuclear chromatin-associated protein that is required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S and G2/M phases of the cell cycle. It directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks. MDC1 contains a forkhead-associated (FHA) domain and two BRCT domains, as well as an internal 41-amino acid repeat sequence. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438717 [Multi-domain]  Cd Length: 97  Bit Score: 136.98  E-value: 1.12e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653   32 GRLHIFSGAHGPEKDFPLHLGKNVVGRMPDCSVALPFPSISKQHAEIEILAwdKAPILRDCGSLNGTQIlRPPKVLSPGV 111
Cdd:cd22665      1 GRLKVFSQAHGPEKDFPLYEGENVIGRDPSCSVVLPDKSVSKQHACIEVDG--GTHLIEDLGSTNGTRI-GNKVRLKPNV 77
                           90       100
                   ....*....|....*....|
gi 2462492653  112 SHRLRDQELILFADLLCQYH 131
Cdd:cd22665     78 RYELIDGDLLLFGDVKCQYV 97
BRCT_MDC1_rpt1 cd17744
first BRCT domain of mediator of DNA damage checkpoint protein 1 (MDC1) and similar proteins; ...
1893-1963 2.10e-27

first BRCT domain of mediator of DNA damage checkpoint protein 1 (MDC1) and similar proteins; MDC1, also termed nuclear factor with BRCT domains 1 (NFBD1), is a nuclear chromatin-associated protein that is required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle. It directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks. MDC1 contains a forkhead-associated (FHA) domain and two BRCT domains, as well as an internal 41-amino acid repeat sequence. The family corresponds to the first BRCT domain.


Pssm-ID: 349375 [Multi-domain]  Cd Length: 72  Bit Score: 106.93  E-value: 2.10e-27
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462492653 1893 PKVLFTGVVD-ARGERAVLALGGSLAGSAAEASHLVTDRIRRTVKFLCALGRGIPILSLDWLHQSRKAGFFL 1963
Cdd:cd17744      1 PRVLFTGVSDkEEGEKIIKKLGGSVVDSVEDCTHLVTDKVRRTVKFLCALARGIPIVSPDWLEASIKANKFL 72
PHA03247 PHA03247
large tegument protein UL36; Provisional
1227-1757 1.68e-17

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 90.00  E-value: 1.68e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1227 ATRGRKNRSSVKTPEPVVPTAP-ELQPSTSTDQPVtSEPTYQAT----RGRKNRSSVKTPEPVVPTAPELRPSTsTDRPV 1301
Cdd:PHA03247  2491 AAGAAPDPGGGGPPDPDAPPAPsRLAPAILPDEPV-GEPVHPRMltwiRGLEELASDDAGDPPPPLPPAAPPAA-PDRSV 2568
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1302 -TPKPTSRttrsrtnmssvktpetvvPTAPELQiSTSTDQPVTPKPTsrttRSRTNMSSVKNPESTVPIAPeLPPSTSTE 1380
Cdd:PHA03247  2569 pPPRPAPR------------------PSEPAVT-SRARRPDAPPQSA----RPRAPVDDRGDPRGPAPPSP-LPPDTHAP 2624
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1381 QPVTPEPTSRATRGRKNRSSGKTP---ETLVPTAPKLEPSTSTDQPVTPEPTSQATRGRTNRSSvktPETVVPTAPELQP 1457
Cdd:PHA03247  2625 DPPPPSPSPAANEPDPHPPPTVPPperPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAA---RPTVGSLTSLADP 2701
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1458 StstDQPVTPEPTSQATrgrtdrsSVKTPETVVPTAPELQASASTDQPVTSEPTSRTTRGRKNRSSVKTPETVVPAAPEL 1537
Cdd:PHA03247  2702 P---PPPPTPEPAPHAL-------VSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAP 2771
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1538 QPSTSTDQPVTPEPTSRATRGRTNRSSVKTPESIVPIAPELQPSTSRNQLVTPEPTSRATRCRTNRSSVKTPEPVVPTAP 1617
Cdd:PHA03247  2772 PAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLP 2851
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1618 -----EPHPTTSTDQPVTPKLTSRATRRKTNRSSVKTPKPVEPAASDLEPFTPTDQSVTPEAIAQGGQSKTLRSSTVRAM 1692
Cdd:PHA03247  2852 lggsvAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQP 2931
                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462492653 1693 PVPTTPEFQSPVTTDQPISPEPITQPSCIKRQRAAGNPGSLAAPIDHKPCSAPLEPKSQASRNQR 1757
Cdd:PHA03247  2932 PPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASSTPPL 2996
FHA COG1716
Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms];
32-110 2.22e-13

Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms];


Pssm-ID: 441322 [Multi-domain]  Cd Length: 96  Bit Score: 67.68  E-value: 2.22e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653   32 GRLHIFSGAHGpEKDFPLHLGKNVVGRMPDCSVALPFPSISKQHAEIEilAWDKAPILRDCGSLNGTQI----LRPPKVL 107
Cdd:COG1716      2 ARLVVLEGPLA-GRRFPLDGGPLTIGRAPDNDIVLDDPTVSRRHARIR--RDGGGWVLEDLGSTNGTFVngqrVTEPAPL 78

                   ...
gi 2462492653  108 SPG 110
Cdd:COG1716     79 RDG 81
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
1120-1460 6.63e-13

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 74.18  E-value: 6.63e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1120 ATSAAPEPHPSTSTAQPVTPKPTsqatrSRTNRSSVKTPEPVVPTAPELQPS--TSTDQPVTSEPTSQVTR---GRKSRS 1194
Cdd:pfam05109  471 ADVTSPTPAGTTSGASPVTPSPS-----PRDNGTESKAPDMTSPTSAVTTPTpnATSPTPAVTTPTPNATSptlGKTSPT 545
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1195 SVKTPETvvPTALELQPSTSTDRPVTSEPTSQATrgrKNRSSVKTPEP--VVPTAPELQPSTST---------DQPVTSE 1263
Cdd:pfam05109  546 SAVTTPT--PNATSPTPAVTTPTPNATIPTLGKT---SPTSAVTTPTPnaTSPTVGETSPQANTtnhtlggtsSTPVVTS 620
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1264 P----TYQATRGRKNRSSVKTpepvvpTAPELRPStSTDRPVTPKPTSRTTRSRTNMSSVKTP--ETVVPTAPElqiSTS 1337
Cdd:pfam05109  621 PpknaTSAVTTGQHNITSSST------SSMSLRPS-SISETLSPSTSDNSTSHMPLLTSAHPTggENITQVTPA---STS 690
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1338 TDQPVT----PKPTSRTTRSRTNMSSVKNPESTVPIAPELPP--STSTEQPV---TPEPTSRATRGRKNRSSGKTPETLV 1408
Cdd:pfam05109  691 THHVSTsspaPRPGTTSQASGPGNSSTSTKPGEVNVTKGTPPknATSPQAPSgqkTAVPTVTSTGGKANSTTGGKHTTGH 770
                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462492653 1409 PTAPKLEPST----STDQPVT--------PEPTSQATRGRTNRSS--VKTPETVVPTAPELQPSTS 1460
Cdd:pfam05109  771 GARTSTEPTTdyggDSTTPRTrynattylPPSTSSKLRPRWTFTSppVTTAQATVPVPPTSQPRFS 836
FHA pfam00498
FHA domain; The FHA (Forkhead-associated) domain is a phosphopeptide binding motif.
55-110 1.36e-10

FHA domain; The FHA (Forkhead-associated) domain is a phosphopeptide binding motif.


Pssm-ID: 459831 [Multi-domain]  Cd Length: 66  Bit Score: 58.74  E-value: 1.36e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462492653   55 VVGRMPDCSVALPFPSISKQHAEIEILAwDKAPILRDCGSLNGT-----QILRPPKVLSPG 110
Cdd:pfam00498    2 TIGRSPDCDIVLDDPSVSRRHAEIRYDG-GGRFYLEDLGSTNGTfvngqRLGPEPVRLKDG 61
FHA smart00240
Forkhead associated domain; Found in eukaryotic and prokaryotic proteins. Putative nuclear ...
55-100 3.22e-08

Forkhead associated domain; Found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain.


Pssm-ID: 214578 [Multi-domain]  Cd Length: 52  Bit Score: 51.41  E-value: 3.22e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*..
gi 2462492653    55 VVGRMP-DCSVALPFPSISKQHAEIEILAWDKApILRDCGSLNGTQI 100
Cdd:smart00240    2 TIGRSSeDCDIQLDGPSISRRHAVIVYDGGGRF-YLIDLGSTNGTFV 47
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
1321-1624 2.18e-07

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 56.54  E-value: 2.18e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1321 TPETVVPTAPELQISTSTDQPVTPKPTSRTTRSRTNMSSVKNPeSTVPIAPELPPSTSTEQPV---TPEPTSRATRGRKN 1397
Cdd:TIGR00927  103 TPSIAMENTPSPPRRTAKITPTTPKNNYSPTAAGTERVKEDTP-ATPSRALNHYISTSGRQRVksyTPKPRGEVKSSSPT 181
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1398 RSSGK----TPETLVPTAPKLEPSTSTDQPvtpeptsqATRGRTNRSSVKTPETvvpTAPELQPSTSTDQPVTPEPTSQA 1473
Cdd:TIGR00927  182 QTREKvrkyTPSPLGRMVNSYAPSTFMTMP--------RSHGITPRTTVKDSEI---TATYKMLETNPSKRTAGKTTPTP 250
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1474 TRGRTDRSS---VKTPETVVPTAPELQASAST-DQPVTSEPTSRTT-RGRKNRSSVKTPETVV----PAAPELQPSTSTD 1544
Cdd:TIGR00927  251 LKGMTDNTPtflTREVETDLLTSPRSVVEKNTlTTPRRVESNSSTNhWGLVGKNNLTTPQGTVlehtPATSEGQVTISIM 330
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1545 QPVTPEPTSRATRGRTNRS-SVKTPESIVPIAP------ELQPSTSRNQLVTPE----PTSRATRCrtnrsSVKTPEPVV 1613
Cdd:TIGR00927  331 TGSSPAETKASTAAWKIRNpLSRTSAPAVRIASatfrglEKNPSTAPSTPATPRvravLTTQVHHC-----VVVKPAPAV 405
                          330
                   ....*....|.
gi 2462492653 1614 PTAPEPHPTTS 1624
Cdd:TIGR00927  406 PTTPSPSLTTA 416
RTT107_BRCT_5 pfam16770
Regulator of Ty1 transposition protein 107 BRCT domain; This is the fifth BRCT domain of ...
1912-1968 7.31e-07

Regulator of Ty1 transposition protein 107 BRCT domain; This is the fifth BRCT domain of regulator of Ty1 transposition protein 107 (RTT107). It is involved in binding phosphorylated histone H2A.


Pssm-ID: 465266  Cd Length: 91  Bit Score: 49.05  E-value: 7.31e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462492653 1912 LGGSLAGSAAEASHLVTDRIRRTVKFLCALGRGIPILSLDWLHQSRKAGFFLPPDEY 1968
Cdd:pfam16770   33 LGIKIVQDPSKCNHLIAPKILRTEKFLCALAFAPYILSPDFITDCLKEGKLPDEEDY 89
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
943-1376 1.01e-06

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 54.31  E-value: 1.01e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653  943 ERDTQRGEPEGGSQDQKgQASSPTPEPGVGAGDLPGPTSAPVPS-----GSQSGGRGSPVSPRRHQ-----KGLLNCKMP 1012
Cdd:PTZ00449   528 EGEEGEHEDSKESDEPK-EGGKPGETKEGEVGKKPGPAKEHKPSkiptlSKKPEFPKDPKHPKDPEepkkpKRPRSAQRP 606
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1013 PAEKASRIRAAEKVSRgdqeSPDACLPPTVPEAPAPPQKPLNSQsqkhlapppllspllpsiKPtvrktrqdgsqEAPEA 1092
Cdd:PTZ00449   607 TRPKSPKLPELLDIPK----SPKRPESPKSPKRPPPPQRPSSPE------------------RP-----------EGPKI 653
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1093 PLSSElEPFHPKPKIRTRKSSRMTPFPATSAAPEPHPSTSTAQPVTPKPTSQATRSRTNRSSVKTPEPVVPTAPelqpst 1172
Cdd:PTZ00449   654 IKSPK-PPKSPKPPFDPKFKEKFYDDYLDAAAKSKETKTTVVLDESFESILKETLPETPGTPFTTPRPLPPKLP------ 726
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1173 sTDQPVTSEPTSQVTRGRKSRSSVKTPETVVPTALELQPSTSTDRPVTSEPTsqatrgRKNRSSVKTPEPVVPTAPELQP 1252
Cdd:PTZ00449   727 -RDEEFPFEPIGDPDAEQPDDIEFFTPPEEERTFFHETPADTPLPDILAEEF------KEEDIHAETGEPDEAMKRPDSP 799
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1253 STSTDQPVTSEPTYQATRGRKNRSSVKTPEpvVPTAPELRPSTSTDRPVTPKptsrTTRSRTNMSSVKTPETVVPTAPEL 1332
Cdd:PTZ00449   800 SEHEDKPPGDHPSLPKKRHRLDGLALSTTD--LESDAGRIAKDASGKIVKLK----RSKSFDDLTTVEEAEEMGAEARKI 873
                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2462492653 1333 QIS---TSTD----QPVTPKPTSRTTRSRTNMSSVKNPESTVPIAPELPPS 1376
Cdd:PTZ00449   874 VVDddgTEADdedtHPPEEKHKSEVRRRRPPKKPSKPKKPSKPKKPKKPDS 924
Agg_substance NF033875
LPXTG-anchored aggregation substance; Aggregation substances, as described in Enterococcus, ...
1415-1542 8.52e-06

LPXTG-anchored aggregation substance; Aggregation substances, as described in Enterococcus, are LPXTG-anchored large surface proteins that contribute to virulence. Several closely related paralogs may be found in a single strain.


Pssm-ID: 411439 [Multi-domain]  Cd Length: 1306  Bit Score: 51.25  E-value: 8.52e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1415 EPSTSTDQPVTPEPTSQATrgrtnrssvkTPETVVPTAPELQPSTsTDQPVTPEPTSQATRGrTDRSSVKTPETVVPTAP 1494
Cdd:NF033875    49 QPGTTTVQPDNPDPQSGSE----------TPKTAVSEEATVQKDT-TSQPTKVEEVASEKNG-AEQSSATPNDTTNAQQP 116
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 2462492653 1495 ELQASAST-DQPVTSEPTSRTTRGRknrssvktPETVVPAAPELQPSTS 1542
Cdd:NF033875   117 TVGAEKSAqEQPVVSPETTNEPLGQ--------PTEVAPAENEANKSTS 157
Pneumo_att_G pfam05539
Pneumovirinae attachment membrane glycoprotein G;
1140-1308 3.68e-04

Pneumovirinae attachment membrane glycoprotein G;


Pssm-ID: 114270 [Multi-domain]  Cd Length: 408  Bit Score: 45.42  E-value: 3.68e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1140 KPTSQATRSRTNRSSVKTPEPVVPT--APELQPSTSTDQPVTSEPTSQVT---RGRKSRSSVKTPETVVPTALELQPSTS 1214
Cdd:pfam05539  167 EPKTAVTTSKTTSWPTEVSHPTYPSqvTPQSQPATQGHQTATANQRLSSTepvGTQGTTTSSNPEPQTEPPPSQRGPSGS 246
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1215 TDRPVTSEPTSQATRGRKNRSsvkTPEPVVPTAPElqPSTSTDQPVTSEPTYQATRGRKnrssvKTPEPVVPTAPELRPS 1294
Cdd:pfam05539  247 PQHPPSTTSQDQSTTGDGQEH---TQRRKTPPATS--NRRSPHSTATPPPTTKRQETGR-----PTPRPTATTQSGSSPP 316
                          170
                   ....*....|....
gi 2462492653 1295 TSTDRPVTPKPTSR 1308
Cdd:pfam05539  317 HSSPPGVQANPTTQ 330
Agg_substance NF033875
LPXTG-anchored aggregation substance; Aggregation substances, as described in Enterococcus, ...
1452-1583 2.52e-03

LPXTG-anchored aggregation substance; Aggregation substances, as described in Enterococcus, are LPXTG-anchored large surface proteins that contribute to virulence. Several closely related paralogs may be found in a single strain.


Pssm-ID: 411439 [Multi-domain]  Cd Length: 1306  Bit Score: 43.16  E-value: 2.52e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1452 APEL--QPSTSTDQPVTPEPTSQATrgrtdrssvkTPETVVPTAPELQASaSTDQPVTSEPTSRTTRGRKNRSSVKTPET 1529
Cdd:NF033875    43 AAELdtQPGTTTVQPDNPDPQSGSE----------TPKTAVSEEATVQKD-TTSQPTKVEEVASEKNGAEQSSATPNDTT 111
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2462492653 1530 VVPAAPELQPSTSTDQPVTPEPTSRATRGRtnrssvktPESIVPIAPELQPSTS 1583
Cdd:NF033875   112 NAQQPTVGAEKSAQEQPVVSPETTNEPLGQ--------PTEVAPAENEANKSTS 157
Chi1 COG3469
Chitinase [Carbohydrate transport and metabolism];
1120-1349 3.03e-03

Chitinase [Carbohydrate transport and metabolism];


Pssm-ID: 442692 [Multi-domain]  Cd Length: 534  Bit Score: 42.43  E-value: 3.03e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1120 ATSAAPEPHPSTSTAQPVTPKPTSQATRSRTNRSSVKTPEPVVPTAPELQPSTSTDQPVTSEPTSQVTRGRKSRSSVKTP 1199
Cdd:COG3469      1 SSSVSTAASPTAGGASATAVTLLGAAATAASVTLTAATATTVVSTTGSVVVAASGSAGSGTGTTAASSTAATSSTTSTTA 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1200 ETVVPTALELQPSTSTDRPVTSEPTSQATRGRKNRSSVKTPEPVVPTAPELQPSTSTDQPVTSEPTYQATRGRKNrSSVK 1279
Cdd:COG3469     81 TATAAAAAATSTSATLVATSTASGANTGTSTVTTTSTGAGSVTSTTSSTAGSTTTSGASATSSAGSTTTTTTVSG-TETA 159
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1280 TPEPVVPTAPELRPSTSTDRPVTPKPTsrttrsrtnmssvkTPETVVPTAPELQISTSTDQPVTPKPTSR 1349
Cdd:COG3469    160 TGGTTTTSTTTTTTSASTTPSATTTAT--------------ATTASGATTPSATTTATTTGPPTPGLPKH 215
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
822-962 3.46e-03

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 42.75  E-value: 3.46e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653  822 ERVGPERGPLERETEKL-----LPERQTDVTGEEELTKGKQDREQKQLLARDTQRQE----------SDKNGESASPERD 886
Cdd:TIGR02169  194 DEKRQQLERLRREREKAeryqaLLKEKREYEGYELLKEKEALERQKEAIERQLASLEeeleklteeiSELEKRLEEIEQL 273
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462492653  887 RESLKVEIETSEEIQEKQVQKQTLPSKAFEREVERPVANRECDPAELEEKVPKVILERDTQRGEPEGGSQDQKGQA 962
Cdd:TIGR02169  274 LEELNKKIKDLGEEEQLRVKEKIGELEAEIASLERSIAEKERELEDAEERLAKLEAEIDKLLAEIEELEREIEEER 349
 
Name Accession Description Interval E-value
BRCT_MDC1_rpt2 cd18441
second BRCT domain of mediator of DNA damage checkpoint protein 1 (MDC1) and similar proteins; ...
1995-2075 1.86e-43

second BRCT domain of mediator of DNA damage checkpoint protein 1 (MDC1) and similar proteins; MDC1, also termed nuclear factor with BRCT domains 1 (NFBD1), is a nuclear chromatin-associated protein that is required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle. It directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks. MDC1 contains a forkhead-associated (FHA) domain and two BRCT domains, as well as an internal 41-amino acid repeat sequence. The family corresponds to the second BRCT domain. The Trp-X-X-X-Cys/Ser signature motif of the BRCT family is not conserved in this family.


Pssm-ID: 349394  Cd Length: 81  Bit Score: 152.92  E-value: 1.86e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1995 LLEGYEIYVTPGVQPPPPQMGEIISCCGGTYLPSMPRSYKPQRVVITCPQDFPHCSIPLRVGLPLLSPEFLLTGVLKQEA 2074
Cdd:cd18441      1 LLEGYEIHVTPGVKPEPPQMKDIITCAGGTFLPSMPKTYKPQTVVISCPEDFPHCSPALKAGLPVVSAEFLLTGILRQEA 80

                   .
gi 2462492653 2075 K 2075
Cdd:cd18441     81 D 81
FHA_MDC1 cd22665
forkhead associated (FHA) domain found in mediator of DNA damage checkpoint protein 1 (MDC1) ...
32-131 1.12e-37

forkhead associated (FHA) domain found in mediator of DNA damage checkpoint protein 1 (MDC1) and similar proteins; MDC1, also called nuclear factor with BRCT domains 1 (NFBD1), is a nuclear chromatin-associated protein that is required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S and G2/M phases of the cell cycle. It directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks. MDC1 contains a forkhead-associated (FHA) domain and two BRCT domains, as well as an internal 41-amino acid repeat sequence. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438717 [Multi-domain]  Cd Length: 97  Bit Score: 136.98  E-value: 1.12e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653   32 GRLHIFSGAHGPEKDFPLHLGKNVVGRMPDCSVALPFPSISKQHAEIEILAwdKAPILRDCGSLNGTQIlRPPKVLSPGV 111
Cdd:cd22665      1 GRLKVFSQAHGPEKDFPLYEGENVIGRDPSCSVVLPDKSVSKQHACIEVDG--GTHLIEDLGSTNGTRI-GNKVRLKPNV 77
                           90       100
                   ....*....|....*....|
gi 2462492653  112 SHRLRDQELILFADLLCQYH 131
Cdd:cd22665     78 RYELIDGDLLLFGDVKCQYV 97
BRCT_MDC1_rpt1 cd17744
first BRCT domain of mediator of DNA damage checkpoint protein 1 (MDC1) and similar proteins; ...
1893-1963 2.10e-27

first BRCT domain of mediator of DNA damage checkpoint protein 1 (MDC1) and similar proteins; MDC1, also termed nuclear factor with BRCT domains 1 (NFBD1), is a nuclear chromatin-associated protein that is required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle. It directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks. MDC1 contains a forkhead-associated (FHA) domain and two BRCT domains, as well as an internal 41-amino acid repeat sequence. The family corresponds to the first BRCT domain.


Pssm-ID: 349375 [Multi-domain]  Cd Length: 72  Bit Score: 106.93  E-value: 2.10e-27
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462492653 1893 PKVLFTGVVD-ARGERAVLALGGSLAGSAAEASHLVTDRIRRTVKFLCALGRGIPILSLDWLHQSRKAGFFL 1963
Cdd:cd17744      1 PRVLFTGVSDkEEGEKIIKKLGGSVVDSVEDCTHLVTDKVRRTVKFLCALARGIPIVSPDWLEASIKANKFL 72
BRCT_PAXIP1_rpt6_like cd18432
sixth BRCT domain of PAX-interacting protein 1 (PAXIP1), second BRCT domain of mediator of DNA ...
1995-2073 1.52e-26

sixth BRCT domain of PAX-interacting protein 1 (PAXIP1), second BRCT domain of mediator of DNA damage checkpoint protein 1 (MDC1) and similar proteins; PAXIP1, also termed PAX transactivation activation domain-interacting protein (PTIP), is involved in DNA damage response and in transcriptional regulation through histone methyltransferase (HMT) complexes. It also facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiation. PAXIP1 contains six BRCT repeats. MDC1, also termed nuclear factor with BRCT domains 1 (NFBD1), is a nuclear chromatin-associated protein that is required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle. It directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks. MDC1 contains a forkhead-associated (FHA) domain and two BRCT domains, as well as an internal 41-amino acid repeat sequence. The family corresponds to the sixth BRCT domain of PAXIP1 and the second BRCT domain of MDC1.


Pssm-ID: 349385 [Multi-domain]  Cd Length: 85  Bit Score: 104.97  E-value: 1.52e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1995 LLEGYEIYVTPGVQPPPPQMGEIISCCGGTYLPSMP----RSYKPQRVVITCPQDFPHCSIPLRVGLPLLSPEFLLTGVL 2070
Cdd:cd18432      1 LFEGYTFYVTPNVKPPPEELKEIIEAAGGKVLKKLPtkriEDDDPDTIVISCEEDRKLWKPLKKKGIPIYSVEFILTGIL 80

                   ...
gi 2462492653 2071 KQE 2073
Cdd:cd18432     81 RQK 83
BRCT_PAXIP1_rpt5 cd17712
fifth BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also ...
1892-1963 1.49e-20

fifth BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also termed PAX transactivation activation domain-interacting protein (PTIP), is involved in DNA damage response and in transcriptional regulation through histone methyltransferase (HMT) complexes. It also facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiation. PAXIP1 contains six BRCT repeats. This family corresponds to the fifth BRCT domain.


Pssm-ID: 349344  Cd Length: 75  Bit Score: 87.29  E-value: 1.49e-20
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462492653 1892 APKVLFTGVVDARGER---AVLALGGSLAGSAAEASHLVTDRIRRTVKFLCALGRGIPILSLDWLHQSRKAGFFL 1963
Cdd:cd17712      1 TPRVLFTGFDPVQVRKltkKVTILGGEVVESPQECTHLVAPKVSRTVKFLTAISVCKHIVTPEWLEESFKQGKFL 75
BRCT_PAXIP1_rpt6 cd18440
sixth BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also ...
1995-2073 8.04e-20

sixth BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also termed PAX transactivation activation domain-interacting protein (PTIP), is involved in DNA damage response and in transcriptional regulation through histone methyltransferase (HMT) complexes. It also facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiation. PAXIP1 contains six BRCT repeats. This family corresponds to the sixth BRCT domain. The Trp-X-X-X-Cys/Ser signature motif of the BRCT family is not conserved in this family.


Pssm-ID: 349393  Cd Length: 90  Bit Score: 85.73  E-value: 8.04e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1995 LLEGYEIYVTPGVQPPPPQMGEIISCCGGTYLPSmPRSYKPQR----------VVITCPQDFPHCSIPLRVGLPLLSPEF 2064
Cdd:cd18440      1 LFKGKYFYITPGVKPSPSVLKEIIESAGGKVEKK-RPSLKKIMeknnqgppsyIIITCENDLHLCRDLFRKNIDVYNAEF 79

                   ....*....
gi 2462492653 2065 LLTGVLKQE 2073
Cdd:cd18440     80 ILTGVLRQK 88
PHA03247 PHA03247
large tegument protein UL36; Provisional
1227-1757 1.68e-17

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 90.00  E-value: 1.68e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1227 ATRGRKNRSSVKTPEPVVPTAP-ELQPSTSTDQPVtSEPTYQAT----RGRKNRSSVKTPEPVVPTAPELRPSTsTDRPV 1301
Cdd:PHA03247  2491 AAGAAPDPGGGGPPDPDAPPAPsRLAPAILPDEPV-GEPVHPRMltwiRGLEELASDDAGDPPPPLPPAAPPAA-PDRSV 2568
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1302 -TPKPTSRttrsrtnmssvktpetvvPTAPELQiSTSTDQPVTPKPTsrttRSRTNMSSVKNPESTVPIAPeLPPSTSTE 1380
Cdd:PHA03247  2569 pPPRPAPR------------------PSEPAVT-SRARRPDAPPQSA----RPRAPVDDRGDPRGPAPPSP-LPPDTHAP 2624
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1381 QPVTPEPTSRATRGRKNRSSGKTP---ETLVPTAPKLEPSTSTDQPVTPEPTSQATRGRTNRSSvktPETVVPTAPELQP 1457
Cdd:PHA03247  2625 DPPPPSPSPAANEPDPHPPPTVPPperPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAA---RPTVGSLTSLADP 2701
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1458 StstDQPVTPEPTSQATrgrtdrsSVKTPETVVPTAPELQASASTDQPVTSEPTSRTTRGRKNRSSVKTPETVVPAAPEL 1537
Cdd:PHA03247  2702 P---PPPPTPEPAPHAL-------VSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAP 2771
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1538 QPSTSTDQPVTPEPTSRATRGRTNRSSVKTPESIVPIAPELQPSTSRNQLVTPEPTSRATRCRTNRSSVKTPEPVVPTAP 1617
Cdd:PHA03247  2772 PAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLP 2851
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1618 -----EPHPTTSTDQPVTPKLTSRATRRKTNRSSVKTPKPVEPAASDLEPFTPTDQSVTPEAIAQGGQSKTLRSSTVRAM 1692
Cdd:PHA03247  2852 lggsvAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQP 2931
                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462492653 1693 PVPTTPEFQSPVTTDQPISPEPITQPSCIKRQRAAGNPGSLAAPIDHKPCSAPLEPKSQASRNQR 1757
Cdd:PHA03247  2932 PPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASSTPPL 2996
PHA03247 PHA03247
large tegument protein UL36; Provisional
962-1640 7.48e-17

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 87.69  E-value: 7.48e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653  962 ASSPTPEPGVGAG---DLPGPTSAPVPSGSQSGGRGSPVSPRrhqkgllnckmppaeKASRIRAAEKVSRGDQESPDACL 1038
Cdd:PHA03247  2491 AAGAAPDPGGGGPpdpDAPPAPSRLAPAILPDEPVGEPVHPR---------------MLTWIRGLEELASDDAGDPPPPL 2555
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1039 PPTVPeAPAPPQKPLNSQSQKHLAPPPLlspllpsikpTVRKTRqdgsqeaPEAPlsseLEPFHPKPKIRTRKSSRMTPf 1118
Cdd:PHA03247  2556 PPAAP-PAAPDRSVPPPRPAPRPSEPAV----------TSRARR-------PDAP----PQSARPRAPVDDRGDPRGPA- 2612
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1119 PATSAAPEPHPststaqpvtPKPTSQATRSRTNRSSVKTPepvVPTAPELQPSTSTDQPVTSEPTSQVTRGRKSRSSvKT 1198
Cdd:PHA03247  2613 PPSPLPPDTHA---------PDPPPPSPSPAANEPDPHPP---PTVPPPERPRDDPAPGRVSRPRRARRLGRAAQAS-SP 2679
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1199 PETVVPTALE--LQPSTSTDRPVTSEPTSQAtrgRKNRSSVKTPEPVVPTAPELQPSTSTDQPVT-SEPTYQATRGRKNR 1275
Cdd:PHA03247  2680 PQRPRRRAARptVGSLTSLADPPPPPPTPEP---APHALVSATPLPPGPAAARQASPALPAAPAPpAVPAGPATPGGPAR 2756
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1276 ssvkTPEPVVPTAPElRPSTSTDRPVTPKPtsRTTRSRTNMSSVKTPETVVPTAPelqistSTDQPVTPKPTSRTTRSRT 1355
Cdd:PHA03247  2757 ----PARPPTTAGPP-APAPPAAPAAGPPR--RLTRPAVASLSESRESLPSPWDP------ADPPAAVLAPAAALPPAAS 2823
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1356 NMSSVKNPESTVPIAPELPPSTSteQPVTPEPTSRATRGRKNRSSGKTPETLVPTAPKLEPSTSTDQPVTPEPTSqatrg 1435
Cdd:PHA03247  2824 PAGPLPPPTSAQPTAPPPPPGPP--PPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTE----- 2896
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1436 rtnrssvktPETVVPTAPELQPSTSTDQPVTPEPTSQAtrgrtdrSSVKTPETVVPTAPELQASASTDQPVTSEPTSRTT 1515
Cdd:PHA03247  2897 ---------SFALPPDQPERPPQPQAPPPPQPQPQPPP-------PPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVP 2960
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1516 RGRKNRSSVKTPETVVPAAPELQPSTSTDQPVTPEPTSRATRGRTNRSSvktpESIVPIAPELQPSTSRNQLVTPEPT-- 1593
Cdd:PHA03247  2961 QPWLGALVPGRVAVPRFRVPQPAPSREAPASSTPPLTGHSLSRVSSWAS----SLALHEETDPPPVSLKQTLWPPDDTed 3036
                          650       660       670       680
                   ....*....|....*....|....*....|....*....|....*...
gi 2462492653 1594 SRATRCRTNRSSVKTPEPVVPTAPEPH-PTTSTDQPVTPKLTSRATRR 1640
Cdd:PHA03247  3037 SDADSLFDSDSERSDLEALDPLPPEPHdPFAHEPDPATPEAGARESPS 3084
FHA cd00060
forkhead associated (FHA) domain superfamily; Forkhead-associated (FHA) domains are small ...
33-110 1.04e-13

forkhead associated (FHA) domain superfamily; Forkhead-associated (FHA) domains are small phosphopeptide recognition modules mostly found in eubacteria and eukaryotes. It is about 95-120 residues long that fold into an 11-stranded beta-sandwich. FHA domains can mediate the recognition of phosphorylated and non-phosphorylated substrates, as well as protein oligomerization. They specifically recognize threonine phosphorylation (pThr) accompanying activation of protein serine/threonine kinases. FHA domains show diverse ligand specificity. They may recognize the pTXXD motif, the pTXXI/L motif, and TQ clusters (singly and multiply phosphorylated). In eukaryotes, FHA superfamily members include forkhead-type transcription factors, as well as other signaling proteins, such as many regulatory proteins, kinases, phosphatases, motor proteins called kinesins, and metabolic enzymes. Many of them localize to the nucleus, where they participate in establishing or maintaining cell cycle checkpoints, DNA repair, or transcriptional regulation. FHA domains play important roles in human diseases, particularly in relation to DNA damage responses and cancers. In bacteria, FHA domain-containing proteins may participate in injection of viral proteins into host cells, transmembrane transporters, and cell division. FHA domain-containing proteins rarely include more than one copy of the domain. The only exception in eukaryotes is the checkpoint kinase Rad53 from Saccharomyces cerevisiae, which harbors two FHA domains (FHA1 and FHA2) flanking a central kinase domain. The two FHA domains recognize different phosphorylated targets and function independently from one another. In contrast, Mycobacterium tuberculosis ABC transporter Rv1747 contains two FHA domains but only one of them is essential for protein function.


Pssm-ID: 438714 [Multi-domain]  Cd Length: 92  Bit Score: 68.46  E-value: 1.04e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653   33 RLHIFSGAHGPEKdFPLHLGKNVVGRMPDCSVALPFPSISKQHAEIEILawDKAPILRDCGSLNGTQI----LRPPKVLS 108
Cdd:cd00060      1 RLIVLDGDGGGRE-FPLTKGVVTIGRSPDCDIVLDDPSVSRRHARIEVD--GGGVYLEDLGSTNGTFVngkrITPPVPLQ 77

                   ..
gi 2462492653  109 PG 110
Cdd:cd00060     78 DG 79
FHA COG1716
Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms];
32-110 2.22e-13

Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms];


Pssm-ID: 441322 [Multi-domain]  Cd Length: 96  Bit Score: 67.68  E-value: 2.22e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653   32 GRLHIFSGAHGpEKDFPLHLGKNVVGRMPDCSVALPFPSISKQHAEIEilAWDKAPILRDCGSLNGTQI----LRPPKVL 107
Cdd:COG1716      2 ARLVVLEGPLA-GRRFPLDGGPLTIGRAPDNDIVLDDPTVSRRHARIR--RDGGGWVLEDLGSTNGTFVngqrVTEPAPL 78

                   ...
gi 2462492653  108 SPG 110
Cdd:COG1716     79 RDG 81
PHA03247 PHA03247
large tegument protein UL36; Provisional
1362-1830 3.83e-13

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 75.75  E-value: 3.83e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1362 NPESTVPIAPELPPSTSTEQP--VTPEPTSRATRGR-----------KNRSSGKTPETLVPTAPKLEPSTSTDQP-VTPE 1427
Cdd:PHA03247  2497 DPGGGGPPDPDAPPAPSRLAPaiLPDEPVGEPVHPRmltwirgleelASDDAGDPPPPLPPAAPPAAPDRSVPPPrPAPR 2576
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1428 PTSQATRGRTNRSSVKtPETVVPTAPeLQPSTSTDQPVTPEPTSQATRGRTDRSSVKTPETVVPTAPELQASASTDQPVT 1507
Cdd:PHA03247  2577 PSEPAVTSRARRPDAP-PQSARPRAP-VDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRD 2654
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1508 SEPTSRTTRGRKNRSSVKTPEtvvPAAPELQPSTSTDQPVTPEPTSRATrgrtnrssvktpesivPIAPELQPSTSRNQL 1587
Cdd:PHA03247  2655 DPAPGRVSRPRRARRLGRAAQ---ASSPPQRPRRRAARPTVGSLTSLAD----------------PPPPPPTPEPAPHAL 2715
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1588 VTPEPTSRATRCRTNRSSVKTPEPVVPTAPEPHPTTSTDQPV-TPKLTSRATRRKTNRSSVKTPKP--VEPAASDLEPFT 1664
Cdd:PHA03247  2716 VSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPaRPPTTAGPPAPAPPAAPAAGPPRrlTRPAVASLSESR 2795
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1665 PTDQSVTPEAIAQGGQSKTLRSSTVRAMPVPTTPEFQSPVTTDQPISPEPITQPSCIKRQRAAGNPGSLAAPIDHKPCSA 1744
Cdd:PHA03247  2796 ESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKP 2875
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1745 PLEPKSQASRNQRWGAVRAAESLTAIPEPASPQLLETPIHASQIQKVEPAGRSRFTPELQPKASQSrkrSLATMDSPPHQ 1824
Cdd:PHA03247  2876 AAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQP---PLAPTTDPAGA 2952

                   ....*.
gi 2462492653 1825 KQPQRG 1830
Cdd:PHA03247  2953 GEPSGA 2958
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
1120-1460 6.63e-13

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 74.18  E-value: 6.63e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1120 ATSAAPEPHPSTSTAQPVTPKPTsqatrSRTNRSSVKTPEPVVPTAPELQPS--TSTDQPVTSEPTSQVTR---GRKSRS 1194
Cdd:pfam05109  471 ADVTSPTPAGTTSGASPVTPSPS-----PRDNGTESKAPDMTSPTSAVTTPTpnATSPTPAVTTPTPNATSptlGKTSPT 545
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1195 SVKTPETvvPTALELQPSTSTDRPVTSEPTSQATrgrKNRSSVKTPEP--VVPTAPELQPSTST---------DQPVTSE 1263
Cdd:pfam05109  546 SAVTTPT--PNATSPTPAVTTPTPNATIPTLGKT---SPTSAVTTPTPnaTSPTVGETSPQANTtnhtlggtsSTPVVTS 620
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1264 P----TYQATRGRKNRSSVKTpepvvpTAPELRPStSTDRPVTPKPTSRTTRSRTNMSSVKTP--ETVVPTAPElqiSTS 1337
Cdd:pfam05109  621 PpknaTSAVTTGQHNITSSST------SSMSLRPS-SISETLSPSTSDNSTSHMPLLTSAHPTggENITQVTPA---STS 690
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1338 TDQPVT----PKPTSRTTRSRTNMSSVKNPESTVPIAPELPP--STSTEQPV---TPEPTSRATRGRKNRSSGKTPETLV 1408
Cdd:pfam05109  691 THHVSTsspaPRPGTTSQASGPGNSSTSTKPGEVNVTKGTPPknATSPQAPSgqkTAVPTVTSTGGKANSTTGGKHTTGH 770
                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462492653 1409 PTAPKLEPST----STDQPVT--------PEPTSQATRGRTNRSS--VKTPETVVPTAPELQPSTS 1460
Cdd:pfam05109  771 GARTSTEPTTdyggDSTTPRTrynattylPPSTSSKLRPRWTFTSppVTTAQATVPVPPTSQPRFS 836
BRCT_BRC1_like_rpt5 cd17743
fifth BRCT domain of Schizosaccharomyces pombe BRCT-containing protein 1 (BRC1) and similar ...
1894-1960 1.96e-12

fifth BRCT domain of Schizosaccharomyces pombe BRCT-containing protein 1 (BRC1) and similar proteins; Schizosaccharomyces pombe BRC1 is required for mitotic fidelity, specifically in the G2 phase of the cell cycle. It plays a role in chromatin organization. The family also includes Cryptococcus neoformans DNA ligase 4 (LIG4, also known as DNA ligase IV or polydeoxyribonucleotide synthase [ATP] 4), which is involved in dsDNA break repair, and plays a role in non-homologous integration (NHI) pathways where it is required in the final step of non-homologus end-joining. Members in this family contain six BRCT domains. This family corresponds to the fifth one.


Pssm-ID: 349374  Cd Length: 70  Bit Score: 64.19  E-value: 1.96e-12
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462492653 1894 KVLFTGVVDARGE--RAVLALGGSLAGSAAEASHLVTDRIRRTVKFLCALGRGIPILSLDWLHQSRKAG 1960
Cdd:cd17743      2 RLLFTGYKLWTEKeiKKLKKLGISIVEDPDECTHLVAPKIVRTEKFLCALAYAPVIVTTDWLEACLKAG 70
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
1322-1683 6.12e-12

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 71.10  E-value: 6.12e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1322 PETVVPTAPELQISTSTDQPVTPK-PTSRTTRSRTNMSSVKNPESTVPiapeLPPSTSTEQPVTPEPtsratrgrknrSS 1400
Cdd:pfam05109  400 PKTLIITRTATNATTTTHKVIFSKaPESTTTSPTLNTTGFAAPNTTTG----LPSSTHVPTNLTAPA-----------ST 464
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1401 GKTPETLVPTAPKLEPSTSTDQPVTPEPTSqatrgRTNRSSVKTPETVVPTAPELQPSTSTDQP----VTPEPTSQA-TR 1475
Cdd:pfam05109  465 GPTVSTADVTSPTPAGTTSGASPVTPSPSP-----RDNGTESKAPDMTSPTSAVTTPTPNATSPtpavTTPTPNATSpTL 539
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1476 GRTDRSSVKTPETvvPTAPELQASASTDQPVTSEPTSRTTrGRKNRSSVKTPETVVPAAPELQPSTST---------DQP 1546
Cdd:pfam05109  540 GKTSPTSAVTTPT--PNATSPTPAVTTPTPNATIPTLGKT-SPTSAVTTPTPNATSPTVGETSPQANTtnhtlggtsSTP 616
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1547 VTPEP----TSRATRGRTNRSSVKTPE-SIVP--IAPELQPSTSRNQ------LVTPEPTSRATRCRTNRSSVKTpEPVV 1613
Cdd:pfam05109  617 VVTSPpknaTSAVTTGQHNITSSSTSSmSLRPssISETLSPSTSDNStshmplLTSAHPTGGENITQVTPASTST-HHVS 695
                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462492653 1614 PTAPEPHPTTsTDQPVTPKLTSRATrrKTNRSSVKTPKPVEPAASdlePFTPTDQ-SVTPEAIAQGGQSKT 1683
Cdd:pfam05109  696 TSSPAPRPGT-TSQASGPGNSSTST--KPGEVNVTKGTPPKNATS---PQAPSGQkTAVPTVTSTGGKANS 760
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
1280-1718 1.03e-11

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 70.33  E-value: 1.03e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1280 TPEPVVPTAPELRPSTSTDRPVTPKPTSRTTRSRTNMSSVKTPETVVPTAPElqiSTSTDQPVTPKPTSRTTRSRTNMSS 1359
Cdd:pfam05109  429 TTSPTLNTTGFAAPNTTTGLPSSTHVPTNLTAPASTGPTVSTADVTSPTPAG---TTSGASPVTPSPSPRDNGTESKAPD 505
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1360 VKNPESTVPIApelPPSTSTEQPVTPEPTSRATrgrkNRSSGKTPETLVPTAPKlePSTSTDQPVTPEPTSQATRGRTNR 1439
Cdd:pfam05109  506 MTSPTSAVTTP---TPNATSPTPAVTTPTPNAT----SPTLGKTSPTSAVTTPT--PNATSPTPAVTTPTPNATIPTLGK 576
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1440 SSvktpetvvPTAPELQPSTSTDQPVTPEPTSQA-TRGRTDRSSVKTPETVVPTAPELQASASTDQPVTSEPTSRTTRGR 1518
Cdd:pfam05109  577 TS--------PTSAVTTPTPNATSPTVGETSPQAnTTNHTLGGTSSTPVVTSPPKNATSAVTTGQHNITSSSTSSMSLRP 648
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1519 KNRSSVKTPETVVPAAPELqPSTSTDQPVTPEPTSRATRGRTNRSSVKTPesivpiAPELQPSTsrnqlvtpepTSRATR 1598
Cdd:pfam05109  649 SSISETLSPSTSDNSTSHM-PLLTSAHPTGGENITQVTPASTSTHHVSTS------SPAPRPGT----------TSQASG 711
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1599 CRTNRSSVKTPEPVVPTAPEPHPTTSTDQPVTPKL---TSRATRRKTNRSSVKTPKPVEPAASDLEPFTPtdqsvtpeai 1675
Cdd:pfam05109  712 PGNSSTSTKPGEVNVTKGTPPKNATSPQAPSGQKTavpTVTSTGGKANSTTGGKHTTGHGARTSTEPTTD---------- 781
                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2462492653 1676 aQGGQSKTLRS--STVRAMPVPTTPEFQ-------SPVTTDQPISP-EPITQP 1718
Cdd:pfam05109  782 -YGGDSTTPRTryNATTYLPPSTSSKLRprwtftsPPVTTAQATVPvPPTSQP 833
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
1350-1736 1.08e-11

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 69.60  E-value: 1.08e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1350 TTRSRTNMSSVKNPESTVPIAPELPPSTSTEQPVTPEPTSRATRGRKNRSSGKTPETLVPTAPKLEPSTStdqPVTPEPT 1429
Cdd:pfam17823   53 KSSEQ*NFCAATAAPAPVTLTKGTSAAHLNSTEVTAEHTPHGTDLSEPATREGAADGAASRALAAAASSS---PSSAAQS 129
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1430 SQATRGRTNRSSVKTPETVVPTAP-ELQPSTSTDQPVTPEPTSQATRGRTDRSSVKTPETVVPTAPELQASA--STDQPV 1506
Cdd:pfam17823  130 LPAAIAALPSEAFSAPRAAACRANaSAAPRAAIAAASAPHAASPAPRTAASSTTAASSTTAASSAPTTAASSapATLTPA 209
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1507 TSEPTSRTTRGRKNRSSVKTP-ETVVPAAPELQPSTSTDQPVTPepTSRATRGRTNRSSVKTPESIVPIAPELQPST--- 1582
Cdd:pfam17823  210 RGISTAATATGHPAAGTALAAvGNSSPAAGTVTAAVGTVTPAAL--ATLAAAAGTVASAAGTINMGDPHARRLSPAKhmp 287
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1583 SRNQLVTPEPTSRAtRCRTNRSSVKTPEPVVPTAPEPHPTtstdqpvtpkltsratrrktnrssvktpkpvePAASDLEP 1662
Cdd:pfam17823  288 SDTMARNPAAPMGA-QAQGPIIQVSTDQPVHNTAGEPTPS--------------------------------PSNTTLEP 334
                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462492653 1663 FTPTDQSVTPEAIAQGGQSKTLRSStvrAMPVPTTPEFQSPVTTdqpiSPEPITQPSCIKRQRAAGNPGSLAAP 1736
Cdd:pfam17823  335 NTPKSVASTNLAVVTTTKAQAKEPS---ASPVPVLHTSMIPEVE----ATSPTTQPSPLLPTQGAAGPGILLAP 401
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
1103-1510 1.61e-11

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 69.95  E-value: 1.61e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1103 PKPKIRTRKSSRMTPFPAT---SAAPEPHPSTST------AQPVTPKPTSQATRSRTNRSSVKTPEPVVPTAPELQPS-- 1171
Cdd:pfam05109  400 PKTLIITRTATNATTTTHKvifSKAPESTTTSPTlnttgfAAPNTTTGLPSSTHVPTNLTAPASTGPTVSTADVTSPTpa 479
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1172 --TSTDQPVTSEPTSqvtrgRKSRSSVKTPETVVPTALELQPS--TSTDRPVTSEPTSQATRGRKNRSS----VKTPepv 1243
Cdd:pfam05109  480 gtTSGASPVTPSPSP-----RDNGTESKAPDMTSPTSAVTTPTpnATSPTPAVTTPTPNATSPTLGKTSptsaVTTP--- 551
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1244 VPTAPELQPSTSTDQPVTSEPTYQATrgrKNRSSVKTPEP--VVPTAPELRPSTSTDRPVTPKPTSR---TTRSRTNMSS 1318
Cdd:pfam05109  552 TPNATSPTPAVTTPTPNATIPTLGKT---SPTSAVTTPTPnaTSPTVGETSPQANTTNHTLGGTSSTpvvTSPPKNATSA 628
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1319 VKTPETVVPTAPELQIS---TSTDQPVTPKpTSRTTRSRTNMSSVKNPESTVPIAPELPPSTSTEQPVTPEP------TS 1389
Cdd:pfam05109  629 VTTGQHNITSSSTSSMSlrpSSISETLSPS-TSDNSTSHMPLLTSAHPTGGENITQVTPASTSTHHVSTSSPaprpgtTS 707
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1390 RATRGRKNRSSGKTPETLVPTAPKLEPSTSTDQPV---TPEPTSQATRGRTNRSSVKTPETVVPTAPELQPSTS-TDQPV 1465
Cdd:pfam05109  708 QASGPGNSSTSTKPGEVNVTKGTPPKNATSPQAPSgqkTAVPTVTSTGGKANSTTGGKHTTGHGARTSTEPTTDyGGDST 787
                          410       420       430       440
                   ....*....|....*....|....*....|....*....|....*.
gi 2462492653 1466 TPEPTSQATRGRTDRSSVK-TPETVVPTAPELQASASTDQPVTSEP 1510
Cdd:pfam05109  788 TPRTRYNATTYLPPSTSSKlRPRWTFTSPPVTTAQATVPVPPTSQP 833
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
1111-1549 3.75e-11

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 68.06  E-value: 3.75e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1111 KSSRMTPFPATSAAPEPHPSTstaqpvtpKPTSQATRSRTNRSSVKTPEpvvptapelqpSTSTDQPVTSEPTSQVTRGR 1190
Cdd:pfam17823   53 KSSEQ*NFCAATAAPAPVTLT--------KGTSAAHLNSTEVTAEHTPH-----------GTDLSEPATREGAADGAASR 113
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1191 ----KSRSSVKTPETVVPTALELQPSTSTDRPVTSEPTSQATRGrknrSSVKTPEPVVPTAPELQPSTSTDQPVTSEPTY 1266
Cdd:pfam17823  114 alaaAASSSPSSAAQSLPAAIAALPSEAFSAPRAAACRANASAA----PRAAIAAASAPHAASPAPRTAASSTTAASSTT 189
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1267 QATRGrKNRSSVKTPEPVVPTAPELRPSTSTdrpVTPKPTSRTTRSRTNMSSVKTPETVVPTAPELQISTSTDQPVTPKP 1346
Cdd:pfam17823  190 AASSA-PTTAASSAPATLTPARGISTAATAT---GHPAAGTALAAVGNSSPAAGTVTAAVGTVTPAALATLAAAAGTVAS 265
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1347 TSRTTRSRTNMSSVKNPESTVPIAPELPPSTSTEQPVTPEPTSRATRGRKNRSSGKTPeTLVPTAPKLEPSTSTDQPVTP 1426
Cdd:pfam17823  266 AAGTINMGDPHARRLSPAKHMPSDTMARNPAAPMGAQAQGPIIQVSTDQPVHNTAGEP-TPSPSNTTLEPNTPKSVASTN 344
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1427 EPTSQATRGRTNRSSVkTPETVVPTA--PELQPSTSTDQPvTPEPTSQATRGRTdrssvktpetvVPTAPELQASASTDQ 1504
Cdd:pfam17823  345 LAVVTTTKAQAKEPSA-SPVPVLHTSmiPEVEATSPTTQP-SPLLPTQGAAGPG-----------ILLAPEQVATEATAG 411
                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2462492653 1505 PVTSEPTSRTTRGRKnrssvktpetvVPAAPELQPSTS------TDQPVTP 1549
Cdd:pfam17823  412 TASAGPTPRSSGDPK-----------TLAMASCQLSTQgqylvvTTDPLTP 451
PHA03247 PHA03247
large tegument protein UL36; Provisional
1473-1921 8.41e-11

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 68.04  E-value: 8.41e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1473 ATRGRTDRSSVKTPETVVPTAPELQASAS-TDQPVTSEPTSRT---TRGRKNRSSVKTPETVVPAAPELQPSTsTDQPV- 1547
Cdd:PHA03247  2491 AAGAAPDPGGGGPPDPDAPPAPSRLAPAIlPDEPVGEPVHPRMltwIRGLEELASDDAGDPPPPLPPAAPPAA-PDRSVp 2569
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1548 ----TPEPTSRATRGRTNRSSVKtPESIVPIAPELQPSTSRNQLvTPEPTSRATRCRTNRSSVKTPEPVVPTAPEPHPTT 1623
Cdd:PHA03247  2570 pprpAPRPSEPAVTSRARRPDAP-PQSARPRAPVDDRGDPRGPA-PPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVP 2647
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1624 STDQPVTPKLTSRATRRKTNRSSVKTPKPVEPAASDLEP-FTPTDQSVTPEA--IAQGGQSKTLRSSTVRAMPVPTTPEF 1700
Cdd:PHA03247  2648 PPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRaARPTVGSLTSLAdpPPPPPTPEPAPHALVSATPLPPGPAA 2727
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1701 ---QSPVTTDQPISPEPITQPSCIKRQRAAGNPGSLAAPIDHKPCSAPLE-PKSQASRNQRWGAVRAAESLTAIPEPASP 1776
Cdd:PHA03247  2728 arqASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAgPPRRLTRPAVASLSESRESLPSPWDPADP 2807
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1777 QLLETPIHASQIQKVEPAGRSRFTPELQPKAS-----------------------QSRKRSLATMDSPPHQKQPQRGEVS 1833
Cdd:PHA03247  2808 PAAVLAPAAALPPAASPAGPLPPPTSAQPTAPppppgppppslplggsvapggdvRRRPPSRSPAAKPAAPARPPVRRLA 2887
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1834 QKTViiKEEEEDTAEKPGKEEDVVTPKPGKRKRDQAEEEPNRIPSRSLRRTKLNQESTAPKVLFTGVVDARGERAVLALG 1913
Cdd:PHA03247  2888 RPAV--SRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLG 2965

                   ....*...
gi 2462492653 1914 GSLAGSAA 1921
Cdd:PHA03247  2966 ALVPGRVA 2973
FHA pfam00498
FHA domain; The FHA (Forkhead-associated) domain is a phosphopeptide binding motif.
55-110 1.36e-10

FHA domain; The FHA (Forkhead-associated) domain is a phosphopeptide binding motif.


Pssm-ID: 459831 [Multi-domain]  Cd Length: 66  Bit Score: 58.74  E-value: 1.36e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462492653   55 VVGRMPDCSVALPFPSISKQHAEIEILAwDKAPILRDCGSLNGT-----QILRPPKVLSPG 110
Cdd:pfam00498    2 TIGRSPDCDIVLDDPSVSRRHAEIRYDG-GGRFYLEDLGSTNGTfvngqRLGPEPVRLKDG 61
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
1324-1712 1.39e-10

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 66.14  E-value: 1.39e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1324 TVVPTAP-ELQISTSTDQPVTPKPTSRTTRSRTNMSSVKNPESTV-PIAPELPPSTSTEQPVTPEPTSRATRGRKNRSSG 1401
Cdd:pfam17823   63 ATAAPAPvTLTKGTSAAHLNSTEVTAEHTPHGTDLSEPATREGAAdGAASRALAAAASSSPSSAAQSLPAAIAALPSEAF 142
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1402 KTPETLVPTAP-KLEPSTSTDQPVTPEPTSQATRGRTNRSSVKTPETVVPTAPELQPST--STDQPVTPEPTSQATRGRT 1478
Cdd:pfam17823  143 SAPRAAACRANaSAAPRAAIAAASAPHAASPAPRTAASSTTAASSTTAASSAPTTAASSapATLTPARGISTAATATGHP 222
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1479 DRSSVKTP-ETVVPTAPELQASASTDQPVTSepTSRTTRGRKNRSSVKTPETVVPAAPELQPSTST---DQPVTPEPTSR 1554
Cdd:pfam17823  223 AAGTALAAvGNSSPAAGTVTAAVGTVTPAAL--ATLAAAAGTVASAAGTINMGDPHARRLSPAKHMpsdTMARNPAAPMG 300
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1555 A-TRGRTNRSSVKTPesIVPIAPELQPSTSRNQLVTPEPTSRATRCRT--NRSSVKTPEPVVPTAPEPH----PTTSTDQ 1627
Cdd:pfam17823  301 AqAQGPIIQVSTDQP--VHNTAGEPTPSPSNTTLEPNTPKSVASTNLAvvTTTKAQAKEPSASPVPVLHtsmiPEVEATS 378
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1628 PVTPKLTSRATRRKTNRSSVKTPKPVEPAAsdlepfTPTDQSVTPEAIAQGGqSKTLRSSTVRampvPTTpEFQSPVTTD 1707
Cdd:pfam17823  379 PTTQPSPLLPTQGAAGPGILLAPEQVATEA------TAGTASAGPTPRSSGD-PKTLAMASCQ----LST-QGQYLVVTT 446

                   ....*
gi 2462492653 1708 QPISP 1712
Cdd:pfam17823  447 DPLTP 451
PRK10263 PRK10263
DNA translocase FtsK; Provisional
1119-1672 2.22e-09

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 63.18  E-value: 2.22e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1119 PATSAAPEPHPSTSTAQPVTPKPTSQAtrsrtnrssVKTPEPVVPTAPE---LQPSTSTDQPVTSEPTSQVTRGRKSRSS 1195
Cdd:PRK10263   339 PVTQTPPVASVDVPPAQPTVAWQPVPG---------PQTGEPVIAPAPEgypQQSQYAQPAVQYNEPLQQPVQPQQPYYA 409
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1196 VKTPETVVPTALELQPSTSTDRPVTSEPTSQATRGrkNRSSVKTPEPVVPTAPELQPSTSTDQPVTSEPTYQATRGRKNR 1275
Cdd:PRK10263   410 PAAEQPAQQPYYAPAPEQPAQQPYYAPAPEQPVAG--NAWQAEEQQSTFAPQSTYQTEQTYQQPAAQEPLYQQPQPVEQQ 487
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1276 SSVKtPEPVVPTAPELRPSTSTDRPVtpkpTSRTTRSRTNMSS--------VKTPETVVPTAPELqiSTSTDQPVTPKPT 1347
Cdd:PRK10263   488 PVVE-PEPVVEETKPARPPLYYFEEV----EEKRAREREQLAAwyqpipepVKEPEPIKSSLKAP--SVAAVPPVEAAAA 560
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1348 SRTTRSRTNMSSVKNPESTVPIAPELPPSTSTeqpvTPEPTSRATRG----RKNRSSGKTPETLVPTAPKLePStstdQP 1423
Cdd:PRK10263   561 VSPLASGVKKATLATGAAATVAAPVFSLANSG----GPRPQVKEGIGpqlpRPKRIRVPTRRELASYGIKL-PS----QR 631
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1424 VTPEPTSQATRGRTNRSSVKTPETVVPTAPE---LQPSTSTDQPVTPEPTSQATRGRTDRSSVKTPETVVPTAPELQASA 1500
Cdd:PRK10263   632 AAEEKAREAQRNQYDSGDQYNDDEIDAMQQDelaRQFAQTQQQRYGEQYQHDVPVNAEDADAAAEAELARQFAQTQQQRY 711
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1501 STDQPVTSEPTSRTTRgrkNRSSVKTPETVVPAAPELQPS-----TSTDQPVTPEPTSRATRGRTNRSSVKTPESivPIA 1575
Cdd:PRK10263   712 SGEQPAGANPFSLDDF---EFSPMKALLDDGPHEPLFTPIvepvqQPQQPVAPQQQYQQPQQPVAPQPQYQQPQQ--PVA 786
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1576 PELQPSTSRnQLVTPEPTSRATRcRTNRSSVKTPEPVVPTAPEPhPTTSTDQPVTPKLTSRATRRKTNRSSVKTP--KPV 1653
Cdd:PRK10263   787 PQPQYQQPQ-QPVAPQPQYQQPQ-QPVAPQPQYQQPQQPVAPQP-QYQQPQQPVAPQPQDTLLHPLLMRNGDSRPlhKPT 863
                          570
                   ....*....|....*....
gi 2462492653 1654 EPAASdLEPFTPTDQSVTP 1672
Cdd:PRK10263   864 TPLPS-LDLLTPPPSEVEP 881
BRCT_BRC1_like_rpt6 cd18439
sixth (C-terminal) BRCT domain of Schizosaccharomyces pombe BRCT-containing protein 1 (BRC1) ...
1976-2073 2.89e-09

sixth (C-terminal) BRCT domain of Schizosaccharomyces pombe BRCT-containing protein 1 (BRC1) and similar proteins; Schizosaccharomyces pombe BRC1 is required for mitotic fidelity, specifically in the G2 phase of the cell cycle. It plays a role in chromatin organization. The family also includes Cryptococcus neoformans DNA ligase 4 (LIG4, also known as DNA ligase IV or polydeoxyribonucleotide synthase [ATP] 4), which is involved in dsDNA break repair, and plays a role in non-homologous integration (NHI) pathways where it is required in the final step of non-homologus end-joining. Members in this family contains six BRCT domains. This family corresponds to the sixth repeat.


Pssm-ID: 349392  Cd Length: 116  Bit Score: 56.54  E-value: 2.89e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1976 EKNFGFSLQDALSRARERR--LLEGYEIYVTPGVQPPPPQMGEIISCCGGTYLPSMPRSYKP--------QRVVITCPQD 2045
Cdd:cd18439      1 EKKYGCTLAESLARAKANKgkLLKGYTVYLTPKVKGGVETFKSIVEANGGICNLLRAAKGKLgdgiaekgPVVLISTTKE 80
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 2462492653 2046 ------------FPHCSIPLRvglpllSPEFLLTGVLKQE 2073
Cdd:cd18439     81 kklwpkflknarEGGKEPRVY------STDWLLDVVLRQE 114
BRCT cd00027
C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains; The ...
1893-1956 1.85e-08

C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains; The BRCT (BRCA1 C-terminus) domain is found within many DNA damage repair and cell cycle checkpoint proteins. BRCT domains interact with each other forming homo/hetero BRCT multimers, but are also involved in BRCT-non-BRCT interactions and interactions within DNA strand breaks. BRCT tandem repeats bind to phosphopeptides; it has been shown that the repeats in human BRCA1 bind specifically to pS-X-X-F motifs, mediating the interaction between BRCA1 and the DNA helicase BACH1, or BRCA1 and CtIP, a transcriptional corepressor. It is assumed that BRCT repeats play similar roles in many signaling pathways associated with the response to DNA damage.


Pssm-ID: 349339 [Multi-domain]  Cd Length: 68  Bit Score: 52.75  E-value: 1.85e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462492653 1893 PKVLFTGVVDARGE---RAVLALGGSLAGS-AAEASHLVTDRIRRTVKFLCALGRGIPILSLDWLHQS 1956
Cdd:cd00027      1 LVICFSGLDDEEREelkKLIEALGGKVSESlSSKVTHLIAKSPSGEKYYLAALAWGIPIVSPEWLLDC 68
FHA smart00240
Forkhead associated domain; Found in eukaryotic and prokaryotic proteins. Putative nuclear ...
55-100 3.22e-08

Forkhead associated domain; Found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain.


Pssm-ID: 214578 [Multi-domain]  Cd Length: 52  Bit Score: 51.41  E-value: 3.22e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*..
gi 2462492653    55 VVGRMP-DCSVALPFPSISKQHAEIEILAWDKApILRDCGSLNGTQI 100
Cdd:smart00240    2 TIGRSSeDCDIQLDGPSISRRHAVIVYDGGGRF-YLIDLGSTNGTFV 47
BRCT_TopBP1_rpt7 cd17738
seventh BRCT domain of DNA topoisomerase 2-binding protein 1; TopBP1, also termed DNA ...
1893-1960 1.17e-07

seventh BRCT domain of DNA topoisomerase 2-binding protein 1; TopBP1, also termed DNA topoisomerase II-beta-binding protein 1, or DNA topoisomerase II-binding protein 1, functions in DNA replication and damage response. It binds double-stranded DNA breaks and nicks as well as single-stranded DNA. TopBP1 contains six copies of BRCT domain. The family corresponds to the seventh BRCT domain. The Trp-X-X-X-Cys/Ser signature motif of the BRCT family is missing in this group.


Pssm-ID: 349370 [Multi-domain]  Cd Length: 75  Bit Score: 50.64  E-value: 1.17e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462492653 1893 PKVLFTGVVDArgERA-----VLALGGSLAGSA---AEASHLVTDRIRRTVKFLCALGRGIPILSLDWLHQSRKAG 1960
Cdd:cd17738      2 PVFLLSGFSED--EKKelisiIEKLGGKVLDSDefdPKCTHLICGKPSRSEKFLAACAAGKWILHPSYIEASAKAG 75
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
1271-1679 1.26e-07

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 57.10  E-value: 1.26e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1271 GRKNRSSVKTPEPVVPTAPELRPSTSTDRPVTPKPTSRTTRSRTNMSSVKTPETVVPTAPELQISTSTDQPVTPKPTSRT 1350
Cdd:PHA03307    38 GSQGQLVSDSAELAAVTVVAGAAACDRFEPPTGPPPGPGTEAPANESRSTPTWSLSTLAPASPAREGSPTPPGPSSPDPP 117
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1351 TRSrtnMSSVKNPESTVPIAPELPPSTSTEQPVTPEPTSRATRgrknrSSGKTPETLVPTAPKLEPSTSTDQPVTPEPTS 1430
Cdd:PHA03307   118 PPT---PPPASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGA-----SPAAVASDAASSRQAALPLSSPEETARAPSSP 189
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1431 QATRGrTNRSSVKTPETVVPTAPELQPSTSTDQPVtPEPTSQATRGRTDRSSVKTPETVVPTAPELQASASTDQPVTSEP 1510
Cdd:PHA03307   190 PAEPP-PSTPPAAASPRPPRRSSPISASASSPAPA-PGRSAADDAGASSSDSSSSESSGCGWGPENECPLPRPAPITLPT 267
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1511 TSRTTRGRKNRSSVKTPETVVPAAPELQPSTSTDQPVTPEPTSRatrgRTNRSSVKTPESIVPIAPELQPSTSRNQLVTP 1590
Cdd:PHA03307   268 RIWEASGWNGPSSRPGPASSSSSPRERSPSPSPSSPGSGPAPSS----PRASSSSSSSRESSSSSTSSSSESSRGAAVSP 343
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1591 EPTSRATRCRTNRSSVKTPEPVvPTAPEPHPTTSTDQPVTPKLTSRATRRKTNRSSVKTPKPvEPAASDLEPFTPTDQSV 1670
Cdd:PHA03307   344 GPSPSRSPSPSRPPPPADPSSP-RKRPRPSRAPSSPAASAGRPTRRRARAAVAGRARRRDAT-GRFPAGRPRPSPLDAGA 421

                   ....*....
gi 2462492653 1671 TPEAIAQGG 1679
Cdd:PHA03307   422 ASGAFYARY 430
FHA_DgcB-like cd22682
forkhead associated (FHA) domain found in Bdellovibrio bacteriovorus GGDEF domain protein DgcB ...
38-131 1.42e-07

forkhead associated (FHA) domain found in Bdellovibrio bacteriovorus GGDEF domain protein DgcB and similar proteins; DgcB is a GGDEF enzyme that produces cyclic-di-GMP in response to an unknown stimulus. It appends the C-terminal GGDEF enzymatic domain with an N-terminal forkhead-associated (FHA) domain that acts as a consensus phosphopeptide sensor. The GGDEF and sensory FHA domains form an asymmetrical dimer.


Pssm-ID: 438734 [Multi-domain]  Cd Length: 96  Bit Score: 51.37  E-value: 1.42e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653   38 SGAHGPEKDFPLHLGKNVVGRMPDCSVALPFPSISKQHAEIEILAwdKAPILRDCGSLNGTQIlrPPKVLSPGVSHRLRD 117
Cdd:cd22682      6 IGPPGVGKQFPITESTIVIGRSVESQVQIDDDSVSRYHAKLAVNP--SAVSIIDLGSTNGTIV--NGKKIPKLASCDLQN 81
                           90
                   ....*....|....
gi 2462492653  118 QELILFADLLCQYH 131
Cdd:cd22682     82 GDQIKIGNTIFKFH 95
BRCT_microcephalin_rpt2 cd17736
second BRCT domain of microcephalin and similar proteins; Microcephalin is a DNA damage ...
1895-1963 1.49e-07

second BRCT domain of microcephalin and similar proteins; Microcephalin is a DNA damage response protein involved in regulation of CHK1 and BRCA1. It has been implicated in chromosome condensation and DNA damage induced cellular responses. It may play a role in neurogenesis and regulation of the size of the cerebral cortex. Microcephalin contains three BRCT repeats. This family corresponds to the second repeat.


Pssm-ID: 349368 [Multi-domain]  Cd Length: 76  Bit Score: 50.67  E-value: 1.49e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462492653 1895 VLFTGVVDARGE---RAVLALGG-SLAGSAAE-ASHLVTDRIRRTVKFLCALGRGIPILSLDWLHQSRKAGFFL 1963
Cdd:cd17736      3 LVMTSVHSEEQElleSVVKKLGGfRVEDSVTEkTTHVVVGSPRRTLNVLLGIARGCWILSPDWVLESLEAGKWL 76
BRCT_nibrin cd17741
BRCT domain of nibrin and similar proteins; Nibrin (NBN), also termed Nijmegen breakage ...
1908-1959 1.67e-07

BRCT domain of nibrin and similar proteins; Nibrin (NBN), also termed Nijmegen breakage syndrome protein 1 (NBS1), or cell cycle regulatory protein p95, is a novel DNA double-strand break repair protein that is mutated in Nijmegen breakage syndrome. It is a component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The BRCT (Breast Cancer Suppressor Protein BRCA1, carboxy-terminal) domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo/hetero BRCT multimers, BRCT-non-BRCT interactions, and interactions within DNA strand breaks. The Trp-X-X-X-Cys/Ser signature motif of the BRCT family is absent in this group.


Pssm-ID: 349372 [Multi-domain]  Cd Length: 74  Bit Score: 50.29  E-value: 1.67e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2462492653 1908 AVLALGGSLAGSAAEAS-HLVTDRIRRTVKFLCALGRGIPILSLDWLHQSRKA 1959
Cdd:cd17741     21 IIAKLGGKVVNEWTEECtHLVMSKIKVTVKVICALISGKPIVTPEYLDALLEA 73
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
1321-1624 2.18e-07

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 56.54  E-value: 2.18e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1321 TPETVVPTAPELQISTSTDQPVTPKPTSRTTRSRTNMSSVKNPeSTVPIAPELPPSTSTEQPV---TPEPTSRATRGRKN 1397
Cdd:TIGR00927  103 TPSIAMENTPSPPRRTAKITPTTPKNNYSPTAAGTERVKEDTP-ATPSRALNHYISTSGRQRVksyTPKPRGEVKSSSPT 181
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1398 RSSGK----TPETLVPTAPKLEPSTSTDQPvtpeptsqATRGRTNRSSVKTPETvvpTAPELQPSTSTDQPVTPEPTSQA 1473
Cdd:TIGR00927  182 QTREKvrkyTPSPLGRMVNSYAPSTFMTMP--------RSHGITPRTTVKDSEI---TATYKMLETNPSKRTAGKTTPTP 250
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1474 TRGRTDRSS---VKTPETVVPTAPELQASAST-DQPVTSEPTSRTT-RGRKNRSSVKTPETVV----PAAPELQPSTSTD 1544
Cdd:TIGR00927  251 LKGMTDNTPtflTREVETDLLTSPRSVVEKNTlTTPRRVESNSSTNhWGLVGKNNLTTPQGTVlehtPATSEGQVTISIM 330
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1545 QPVTPEPTSRATRGRTNRS-SVKTPESIVPIAP------ELQPSTSRNQLVTPE----PTSRATRCrtnrsSVKTPEPVV 1613
Cdd:TIGR00927  331 TGSSPAETKASTAAWKIRNpLSRTSAPAVRIASatfrglEKNPSTAPSTPATPRvravLTTQVHHC-----VVVKPAPAV 405
                          330
                   ....*....|.
gi 2462492653 1614 PTAPEPHPTTS 1624
Cdd:TIGR00927  406 PTTPSPSLTTA 416
PRK10263 PRK10263
DNA translocase FtsK; Provisional
1218-1767 2.80e-07

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 56.25  E-value: 2.80e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1218 PVTSEPTSQATRGRKNRSSVKTPEPVVPTAPELQPSTSTDQPVTSeptYQATRGrknrssVKTPEPVVPTAPELRPstst 1297
Cdd:PRK10263   315 PITEPVAVAAAATTATQSWAAPVEPVTQTPPVASVDVPPAQPTVA---WQPVPG------PQTGEPVIAPAPEGYP---- 381
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1298 drpvtPKPTSRTTRSRTNMSSVKtpetvvPTAPELQISTSTDQPVTPKPTSRTTRSRTNMSSVKNPESTVPIAPELPPST 1377
Cdd:PRK10263   382 -----QQSQYAQPAVQYNEPLQQ------PVQPQQPYYAPAAEQPAQQPYYAPAPEQPAQQPYYAPAPEQPVAGNAWQAE 450
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1378 STEQPVTPEPTSRATrgrknrssgKTPETLVPTAPKLEPSTSTDQPVTPEPTSQATRGRTNRSSVKTPETVVPT-APELQ 1456
Cdd:PRK10263   451 EQQSTFAPQSTYQTE---------QTYQQPAAQEPLYQQPQPVEQQPVVEPEPVVEETKPARPPLYYFEEVEEKrARERE 521
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1457 PSTSTDQPVtPEPtsqatrgrtdrssVKTPETVVPTAPELQASASTdqPVTSEPTSRTTRGRKNRSSVKTPETVVPAAPE 1536
Cdd:PRK10263   522 QLAAWYQPI-PEP-------------VKEPEPIKSSLKAPSVAAVP--PVEAAAAVSPLASGVKKATLATGAAATVAAPV 585
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1537 LQPSTSTdqpvTPEPTSRATRG----RTNRSSVKTPESIVPIAPELqPStsrnQLVTPEPTSRATRCRTNRSSVKTPEPV 1612
Cdd:PRK10263   586 FSLANSG----GPRPQVKEGIGpqlpRPKRIRVPTRRELASYGIKL-PS----QRAAEEKAREAQRNQYDSGDQYNDDEI 656
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1613 VPTAPE----------------------PHPTTSTDQPVTPKLTSRATRRKTNRSSVKTPKPVEPAASDLEPFTPTDQ-- 1668
Cdd:PRK10263   657 DAMQQDelarqfaqtqqqrygeqyqhdvPVNAEDADAAAEAELARQFAQTQQQRYSGEQPAGANPFSLDDFEFSPMKAll 736
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1669 -----------SVTPEAIAQgGQSKTLRSSTVRAMPVPTTPEFQSPvttDQPISPEPITQ--PSCIKRQRAAGNPGSLAA 1735
Cdd:PRK10263   737 ddgpheplftpIVEPVQQPQ-QPVAPQQQYQQPQQPVAPQPQYQQP---QQPVAPQPQYQqpQQPVAPQPQYQQPQQPVA 812
                          570       580       590
                   ....*....|....*....|....*....|...
gi 2462492653 1736 P-IDHKPCSAPLEPKSQASRNQRWGAVRAAESL 1767
Cdd:PRK10263   813 PqPQYQQPQQPVAPQPQYQQPQQPVAPQPQDTL 845
RTT107_BRCT_5 pfam16770
Regulator of Ty1 transposition protein 107 BRCT domain; This is the fifth BRCT domain of ...
1912-1968 7.31e-07

Regulator of Ty1 transposition protein 107 BRCT domain; This is the fifth BRCT domain of regulator of Ty1 transposition protein 107 (RTT107). It is involved in binding phosphorylated histone H2A.


Pssm-ID: 465266  Cd Length: 91  Bit Score: 49.05  E-value: 7.31e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462492653 1912 LGGSLAGSAAEASHLVTDRIRRTVKFLCALGRGIPILSLDWLHQSRKAGFFLPPDEY 1968
Cdd:pfam16770   33 LGIKIVQDPSKCNHLIAPKILRTEKFLCALAFAPYILSPDFITDCLKEGKLPDEEDY 89
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
1374-1782 7.93e-07

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 54.79  E-value: 7.93e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1374 PPSTSTEQPVTPeptsraTRGRKNRSSGKTPETLVPTAPKLEPSTSTDQPVTPEPTSQATRGRTNRSSVKTPETVVPTAP 1453
Cdd:PHA03307    24 PPATPGDAADDL------LSGSQGQLVSDSAELAAVTVVAGAAACDRFEPPTGPPPGPGTEAPANESRSTPTWSLSTLAP 97
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1454 ELQPSTSTDQPVTPEPTSqaTRGRTDRSSVKTPETVVPTAPELQASASTDQPVTSEPTSRTTRGRKNRSSVKTPETVVPA 1533
Cdd:PHA03307    98 ASPAREGSPTPPGPSSPD--PPPPTPPPASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAALP 175
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1534 APELQPSTSTDQPVTPEPTSRATRGRTNRSSVKTPESIVPIAPELQPSTSRNQLVTPEPTSRATRCRTNRSSVKTPEPVV 1613
Cdd:PHA03307   176 LSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENEC 255
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1614 PtAPEPHPTTSTDQPVTPKLTSRATRRKTNRSSV-----KTPKPVEPAASDLEPFTPTDQSVTPEAIAQGGQSKTLRSS- 1687
Cdd:PHA03307   256 P-LPRPAPITLPTRIWEASGWNGPSSRPGPASSSsspreRSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSSSSe 334
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1688 TVRAMPVPTTPEFQSPVTTDQPisPEPITQPSCIKRQRAAGNPGSLAAPIDHKPC----SAPLEPKSQASRNQRWGAVRA 1763
Cdd:PHA03307   335 SSRGAAVSPGPSPSRSPSPSRP--PPPADPSSPRKRPRPSRAPSSPAASAGRPTRrrarAAVAGRARRRDATGRFPAGRP 412
                          410
                   ....*....|....*....
gi 2462492653 1764 AESLTAIPEPASPQLLETP 1782
Cdd:PHA03307   413 RPSPLDAGAASGAFYARYP 431
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
943-1376 1.01e-06

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 54.31  E-value: 1.01e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653  943 ERDTQRGEPEGGSQDQKgQASSPTPEPGVGAGDLPGPTSAPVPS-----GSQSGGRGSPVSPRRHQ-----KGLLNCKMP 1012
Cdd:PTZ00449   528 EGEEGEHEDSKESDEPK-EGGKPGETKEGEVGKKPGPAKEHKPSkiptlSKKPEFPKDPKHPKDPEepkkpKRPRSAQRP 606
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1013 PAEKASRIRAAEKVSRgdqeSPDACLPPTVPEAPAPPQKPLNSQsqkhlapppllspllpsiKPtvrktrqdgsqEAPEA 1092
Cdd:PTZ00449   607 TRPKSPKLPELLDIPK----SPKRPESPKSPKRPPPPQRPSSPE------------------RP-----------EGPKI 653
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1093 PLSSElEPFHPKPKIRTRKSSRMTPFPATSAAPEPHPSTSTAQPVTPKPTSQATRSRTNRSSVKTPEPVVPTAPelqpst 1172
Cdd:PTZ00449   654 IKSPK-PPKSPKPPFDPKFKEKFYDDYLDAAAKSKETKTTVVLDESFESILKETLPETPGTPFTTPRPLPPKLP------ 726
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1173 sTDQPVTSEPTSQVTRGRKSRSSVKTPETVVPTALELQPSTSTDRPVTSEPTsqatrgRKNRSSVKTPEPVVPTAPELQP 1252
Cdd:PTZ00449   727 -RDEEFPFEPIGDPDAEQPDDIEFFTPPEEERTFFHETPADTPLPDILAEEF------KEEDIHAETGEPDEAMKRPDSP 799
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1253 STSTDQPVTSEPTYQATRGRKNRSSVKTPEpvVPTAPELRPSTSTDRPVTPKptsrTTRSRTNMSSVKTPETVVPTAPEL 1332
Cdd:PTZ00449   800 SEHEDKPPGDHPSLPKKRHRLDGLALSTTD--LESDAGRIAKDASGKIVKLK----RSKSFDDLTTVEEAEEMGAEARKI 873
                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2462492653 1333 QIS---TSTD----QPVTPKPTSRTTRSRTNMSSVKNPESTVPIAPELPPS 1376
Cdd:PTZ00449   874 VVDddgTEADdedtHPPEEKHKSEVRRRRPPKKPSKPKKPSKPKKPKKPDS 924
FHA_Ki67 cd22673
forkhead associated (FHA) domain found in proliferation marker protein Ki-67 and similar ...
32-125 1.07e-06

forkhead associated (FHA) domain found in proliferation marker protein Ki-67 and similar proteins; Ki-67, also called antigen identified by monoclonal antibody Ki-67, antigen KI-67, or antigen Ki67, acts as a biological surfactant to disperse mitotic chromosomes. It is required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly. Ki-67 binds DNA with a preference for supercoiled DNA and AT-rich DNA. It may also play a role in chromatin organization. Ki-67 contains an FHA domain at its N-terminus. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438725 [Multi-domain]  Cd Length: 95  Bit Score: 48.75  E-value: 1.07e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653   32 GRLHIF--SGAHGPEkdFPLHLGKNVVGRMPDCSVALPFPSISKQHAEIEILAWDKApILRDCGSLNGTQiLRPPKVLSP 109
Cdd:cd22673      1 GKLVVIkkDGTDGSR--FPLTKKSCTFGRDLSCDIRIQLPGVSREHCRIEVDENGKA-YLENLSTTNPTL-VNGKAIEKS 76
                           90
                   ....*....|....*.
gi 2462492653  110 gvsHRLRDQELILFAD 125
Cdd:cd22673     77 ---AELKDGDVITIGG 89
FHA_FhaA-like cd22668
forkhead associated (FHA) domain found in Mycobacterium tuberculosis FHA domain-containing ...
41-100 1.73e-06

forkhead associated (FHA) domain found in Mycobacterium tuberculosis FHA domain-containing protein FhaA and similar proteins; FhaA regulates cell growth and peptidoglycan synthesis by binding to MviN. It may inhibit the late stages of peptidoglycan synthesis. It contains an FHA domain, which is a small phosphopeptide recognition module.


Pssm-ID: 438720 [Multi-domain]  Cd Length: 91  Bit Score: 47.85  E-value: 1.73e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462492653   41 HGPEKDFPLHLGKNVVGRMPDCSVALPFPSISKQHAEIeilAWD-KAPILRDCGSLNGTQI 100
Cdd:cd22668      7 DGSGRVYQLREGSNIIGRGSDADFRLPDTGVSRRHAEI---RWDgQVAHLTDLGSTNGTTV 64
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
1171-1529 2.16e-06

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 53.25  E-value: 2.16e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1171 STSTDQPVTSEPTSQVTRGRKSRSSVKTPETVVPTALELQPSTSTDRPVTSEPTSQATRGRKNRSSVKTPEP----VVPT 1246
Cdd:PHA03307    61 ACDRFEPPTGPPPGPGTEAPANESRSTPTWSLSTLAPASPAREGSPTPPGPSSPDPPPPTPPPASPPPSPAPdlseMLRP 140
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1247 APELQPSTSTDQPVTSEPTYQATRGRKNRSSVKTPEPVVPTAPELRPSTSTDRPVTPKPTSRTTRSRtnmssvktpetvv 1326
Cdd:PHA03307   141 VGSPGPPPAASPPAAGASPAAVASDAASSRQAALPLSSPEETARAPSSPPAEPPPSTPPAAASPRPP------------- 207
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1327 PTAPELQISTSTDQPVTPKpTSRTTRSRTNMSSVKNPESTVPIAPELPPSTSTEQPVTPEPTSRATRGRKNRSSGKTPET 1406
Cdd:PHA03307   208 RRSSPISASASSPAPAPGR-SAADDAGASSSDSSSSESSGCGWGPENECPLPRPAPITLPTRIWEASGWNGPSSRPGPAS 286
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1407 LVPTAPKLEPSTSTDQPVTPEPTSQAT--RGRTNRSSVKTPETVVPTAPELQPSTSTDQPVTPEPTSQATRGRTDRSSVK 1484
Cdd:PHA03307   287 SSSSPRERSPSPSPSSPGSGPAPSSPRasSSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSRSPSPSRPPPPADPSSPR 366
                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462492653 1485 TPETVVPTAPELQASAST-----------DQPVTSEPTSRTTRGRKNRSSVKTPET 1529
Cdd:PHA03307   367 KRPRPSRAPSSPAASAGRptrrraraavaGRARRRDATGRFPAGRPRPSPLDAGAA 422
PRK10263 PRK10263
DNA translocase FtsK; Provisional
1258-1838 2.61e-06

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 52.78  E-value: 2.61e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1258 QPVTSEPTYQATRGRKNRSSVKTPEPVVPTAPELRPSTSTDRPVTPKPTsrttrsrtnMSSVKTPETVVPTAPElqisTS 1337
Cdd:PRK10263   314 APITEPVAVAAAATTATQSWAAPVEPVTQTPPVASVDVPPAQPTVAWQP---------VPGPQTGEPVIAPAPE----GY 380
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1338 TDQPVTPKPTSRttrsrtnmssvKNPESTVPIAPELPPSTSTEQPVTPEPTSRATRGRKNRSSGKTPETLVPTAPKLEPS 1417
Cdd:PRK10263   381 PQQSQYAQPAVQ-----------YNEPLQQPVQPQQPYYAPAAEQPAQQPYYAPAPEQPAQQPYYAPAPEQPVAGNAWQA 449
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1418 TSTDQPVTPEPTSQATRgrtnrssvKTPETVVPTAPELQPStSTDQPVTPEPTSQATRGRTDRSSVKTPETVVPT-APEL 1496
Cdd:PRK10263   450 EEQQSTFAPQSTYQTEQ--------TYQQPAAQEPLYQQPQ-PVEQQPVVEPEPVVEETKPARPPLYYFEEVEEKrARER 520
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1497 QASASTDQPVtSEPtsrttrgrknrssVKTPETVVPAAPelQPSTSTDQPVTPEPTSRATRGRTNRSSVKTPESIVPIAP 1576
Cdd:PRK10263   521 EQLAAWYQPI-PEP-------------VKEPEPIKSSLK--APSVAAVPPVEAAAAVSPLASGVKKATLATGAAATVAAP 584
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1577 ELQPSTSRnqlvTPEPtsratrcrtnrssvKTPEPVVPTAPEPH----PTTSTDQPVTPKLTSRATRRKTNRSSVKTPKP 1652
Cdd:PRK10263   585 VFSLANSG----GPRP--------------QVKEGIGPQLPRPKrirvPTRRELASYGIKLPSQRAAEEKAREAQRNQYD 646
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1653 VEPAASDLEpftpTDQSVTPEAIAQGGQSKTLRSSTVRAMPVPTTPEfqspvTTDQPISPEPITQPSCIKRQRAAG---- 1728
Cdd:PRK10263   647 SGDQYNDDE----IDAMQQDELARQFAQTQQQRYGEQYQHDVPVNAE-----DADAAAEAELARQFAQTQQQRYSGeqpa 717
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1729 --NPGSLA----APID-------HKPCSAP-LEPKSQASRNQRWGAVRAAESLTAIPEPA--SPQLLETPIHASQIQKVE 1792
Cdd:PRK10263   718 gaNPFSLDdfefSPMKallddgpHEPLFTPiVEPVQQPQQPVAPQQQYQQPQQPVAPQPQyqQPQQPVAPQPQYQQPQQP 797
                          570       580       590       600
                   ....*....|....*....|....*....|....*....|....*....
gi 2462492653 1793 PAGRSRFTPELQPKASQSRKRSLATMDSPP---HQKQPQRGEVSQKTVI 1838
Cdd:PRK10263   798 VAPQPQYQQPQQPVAPQPQYQQPQQPVAPQpqyQQPQQPVAPQPQDTLL 846
PRK13914 PRK13914
invasion associated endopeptidase;
1133-1359 3.82e-06

invasion associated endopeptidase;


Pssm-ID: 237555 [Multi-domain]  Cd Length: 481  Bit Score: 51.73  E-value: 3.82e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1133 TAQPVTPKP-------TSQATRSRTNRSSVKTPEPVVPTAPELQPSTSTDQPVTSEPTSQVTRGRKSRS-SVKTPETVVP 1204
Cdd:PRK13914   144 TSTPVAPTQevkkettTQQAAPAAETKTEVKQTTQATTPAPKVAETKETPVVDQNATTHAVKSGDTIWAlSVKYGVSVQD 223
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1205 TALELQPSTSTDRPVTSEPTSQATRGRKNRSSVKTPEPVVP--TAPELQPSTSTDQPVTSeptyqatrgrknRSSVKTPE 1282
Cdd:PRK13914   224 IMSWNNLSSSSIYVGQKLAIKQTANTATPKAEVKTEAPAAEkqAAPVVKENTNTNTATTE------------KKETTTQQ 291
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462492653 1283 PVVPTAPelrpsTSTDRPvTPKPTSRTTRSRTNMSSVKTPETVVPTAPELQISTSTDQPVTPKPTSRTTRSRTNMSS 1359
Cdd:PRK13914   292 QTAPKAP-----TEAAKP-APAPSTNTNANKTNTNTNTNTNNTNTSTPSKNTNTNTNSNTNTNSNTNANQGSSNNNS 362
FHA_PP2C70-like cd22678
forkhead associated (FHA) domain found in Arabidopsis thaliana protein phosphatase 2C 70 ...
56-122 4.51e-06

forkhead associated (FHA) domain found in Arabidopsis thaliana protein phosphatase 2C 70 (AtPP2C70) and similar proteins; AtPP2C70, also called kinase-associated protein phosphatase, or protein ROOT ATTENUATED GROWTH 1, dephosphorylates the serine/threonine receptor-like kinase RLK5. It may function as a signaling component in a pathway involving RLK5. It acts as a negative regulator of the CLAVATA1 signaling in plant development by binding and dephosphorylating CLAVATA1. It is also a component of a signaling pathway which mediates adaptation to NaCl stress. It contains an FHA domain, which is a small phosphopeptide recognition module.


Pssm-ID: 438730 [Multi-domain]  Cd Length: 102  Bit Score: 46.97  E-value: 4.51e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462492653   56 VGRMPDCSVALPFPSISKQHAEIEILAWDKAPILRDCGSLNGTQI-LRPPKVlsPGVSHRLRDQELIL 122
Cdd:cd22678     27 IGRIQRGDIALKDDEVSGKHARIEWNSTGSKWELVDLGSLNGTLVnGESISP--NGRPVVLSSGDVIT 92
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
911-1309 5.06e-06

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 52.10  E-value: 5.06e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653  911 PSKAFEREVERPVANRECDPAELEEKVPKVILERDTQRGEPEGGSQDQKGQASSPTPEPGVgagDLPGPTSAPVPSGSQS 990
Cdd:PHA03307    61 ACDRFEPPTGPPPGPGTEAPANESRSTPTWSLSTLAPASPAREGSPTPPGPSSPDPPPPTP---PPASPPPSPAPDLSEM 137
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653  991 GGRGSPVSPRRHQKgllnckMPPAEKASRIRAAEKVSRGDQESPDACLPPTVPeAPAPPQKPLNSQSQKHLAPPPLlspl 1070
Cdd:PHA03307   138 LRPVGSPGPPPAAS------PPAAGASPAAVASDAASSRQAALPLSSPEETAR-APSSPPAEPPPSTPPAAASPRP---- 206
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1071 lpsikPTVRKTRQDGSQEAPEAPLSSELEPFHPKPKIRTRKSSRMTPFPATSAAPEPHPSTSTAqPVTPKPTSQATRSRT 1150
Cdd:PHA03307   207 -----PRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENECPLPRPAPITL-PTRIWEASGWNGPSS 280
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1151 NRSSVKTPEPVVPTAPELQPSTSTDQPVTSEPTSQVTRGRKSRSSvkTPETVVPTALELQPSTSTDRPVTSEPTSQATRG 1230
Cdd:PHA03307   281 RPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESS--SSSTSSSSESSRGAAVSPGPSPSRSPSPSRPPP 358
                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462492653 1231 RKNRSSVKTPEPVVPTAPelQPSTStdqpvTSEPTYQATRGRKNRSSVKTPEPVVPTAPELRPSTSTDRPVTPKPTSRT 1309
Cdd:PHA03307   359 PADPSSPRKRPRPSRAPS--SPAAS-----AGRPTRRRARAAVAGRARRRDATGRFPAGRPRPSPLDAGAASGAFYARY 430
FHA_Kanadaptin cd22677
forkhead associated (FHA) domain found in kanadaptin and similar proteins; Kanadaptin, also ...
55-116 6.07e-06

forkhead associated (FHA) domain found in kanadaptin and similar proteins; Kanadaptin, also called human lung cancer oncogene 3 protein (HLC-3), kidney anion exchanger adapter protein, or solute carrier family 4 anion exchanger member 1 adapter protein (SLC4A1AP), is a nuclear protein widely expressed in mammalian tissues. It was originally isolated as a kidney Cl-/HCO3- anion exchanger 1 (kAE1)-binding protein. It is a highly mobile nucleocytoplasmic shuttling and multilocalizing protein. Its role in mammalian cells remains unclear. It contains an FHA domain, which is a small phosphopeptide recognition module.


Pssm-ID: 438729 [Multi-domain]  Cd Length: 106  Bit Score: 46.78  E-value: 6.07e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462492653   55 VVGRMPDCSVALPFPSISKQHAeieILAWDKAPI-------LRDCGSLNGTQILRPPkvLSPGVSHRLR 116
Cdd:cd22677     25 VFGRLPGCDVVLEHPSISRYHA---VLQYRGDADdhdggfyLYDLGSTHGTFLNKQR--IPPKQYYRLR 88
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
1242-1676 8.31e-06

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 51.23  E-value: 8.31e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1242 PVVPTAPELQPSTSTDQPVTSEPTYQATRGRKNRSSVKTPEPVVPTAP----ELRPS---TSTDRPVTPKPTsrttrsrt 1314
Cdd:PTZ00449   514 PEASGLPPKAPGDKEGEEGEHEDSKESDEPKEGGKPGETKEGEVGKKPgpakEHKPSkipTLSKKPEFPKDP-------- 585
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1315 nmssvKTPETvvPTAPElqistSTDQPVTP-KPTSRttrsrtnmSSVKNPEST-VPIAPELPPSTSTeqPVTPEPTSRAT 1392
Cdd:PTZ00449   586 -----KHPKD--PEEPK-----KPKRPRSAqRPTRP--------KSPKLPELLdIPKSPKRPESPKS--PKRPPPPQRPS 643
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1393 RGRKNRSSGKTPETLVPTAPKLEPSTSTDQPVTPEPTSQATRGRTNRSSVKTPETVVPTAPELQPSTSTDQPVTPEPTSq 1472
Cdd:PTZ00449   644 SPERPEGPKIIKSPKPPKSPKPPFDPKFKEKFYDDYLDAAAKSKETKTTVVLDESFESILKETLPETPGTPFTTPRPLP- 722
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1473 ATRGRTDRSSVKTPETvvPTAPElqasaSTDQPVTSEPTSRTTRGRKNRSSVKTPETVVPAAPELQPSTSTDQPVTPept 1552
Cdd:PTZ00449   723 PKLPRDEEFPFEPIGD--PDAEQ-----PDDIEFFTPPEEERTFFHETPADTPLPDILAEEFKEEDIHAETGEPDEA--- 792
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1553 srATRGRTNRSSVKTPESIVPIAPELQPSTSRNQLVTPEPTSRATR---------CRTNRSSVKTPEPVVPTAPEPHP-- 1621
Cdd:PTZ00449   793 --MKRPDSPSEHEDKPPGDHPSLPKKRHRLDGLALSTTDLESDAGRiakdasgkiVKLKRSKSFDDLTTVEEAEEMGAea 870
                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462492653 1622 ---------TTSTDQPVTP---KLTSRATRRKTNRSSVKTPKPVEPAasdlEPFTPtDQSVTPEAIA 1676
Cdd:PTZ00449   871 rkivvdddgTEADDEDTHPpeeKHKSEVRRRRPPKKPSKPKKPSKPK----KPKKP-DSAFIPSIIA 932
Agg_substance NF033875
LPXTG-anchored aggregation substance; Aggregation substances, as described in Enterococcus, ...
1415-1542 8.52e-06

LPXTG-anchored aggregation substance; Aggregation substances, as described in Enterococcus, are LPXTG-anchored large surface proteins that contribute to virulence. Several closely related paralogs may be found in a single strain.


Pssm-ID: 411439 [Multi-domain]  Cd Length: 1306  Bit Score: 51.25  E-value: 8.52e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1415 EPSTSTDQPVTPEPTSQATrgrtnrssvkTPETVVPTAPELQPSTsTDQPVTPEPTSQATRGrTDRSSVKTPETVVPTAP 1494
Cdd:NF033875    49 QPGTTTVQPDNPDPQSGSE----------TPKTAVSEEATVQKDT-TSQPTKVEEVASEKNG-AEQSSATPNDTTNAQQP 116
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 2462492653 1495 ELQASAST-DQPVTSEPTSRTTRGRknrssvktPETVVPAAPELQPSTS 1542
Cdd:NF033875   117 TVGAEKSAqEQPVVSPETTNEPLGQ--------PTEVAPAENEANKSTS 157
BRCT_p53bp1_rpt1 cd17745
first (central) BRCT domain in p53-binding protein 1 (p53BP1) and similar proteins; p53BP1, ...
1926-1960 8.65e-06

first (central) BRCT domain in p53-binding protein 1 (p53BP1) and similar proteins; p53BP1, also termed 53BP1, or TP53-binding protein 1 (TP53BP1) , is a double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis. TP53BP1 contains two tandem BRCT repeats. This family also includes Schizosaccharomyces pombe Crb2, which is a checkpoint mediator required for the cellular response to DNA damage. This model corresponds to the first BRCT domain.


Pssm-ID: 349376 [Multi-domain]  Cd Length: 99  Bit Score: 46.15  E-value: 8.65e-06
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2462492653 1926 LVTDRIRRTVKFLCALGRGIPILSLDWLHQSRKAG 1960
Cdd:cd17745     64 LIADSPSRTPKYLQALALGIPCVSHKWILDCIEAG 98
FHA_PS1-like cd22691
forkhead associated (FHA) domain found in Arabidopsis thaliana Protein PARALLEL SPINDLE 1 (PS1) ...
55-98 1.03e-05

forkhead associated (FHA) domain found in Arabidopsis thaliana Protein PARALLEL SPINDLE 1 (PS1) and similar proteins; PS1 is an FHA domain-containing protein required for normal spindle orientation at male meiosis II and normal formation of tetrad of microspores. It is not involved in female meiosis. Mutations in PS1 lead to the production of diploid pollen grains. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438743 [Multi-domain]  Cd Length: 113  Bit Score: 46.64  E-value: 1.03e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 2462492653   55 VVGRMPDCSVALPFPSISKQHAEIEILAWDKAPILRDCGSLNGT 98
Cdd:cd22691     32 VVGRHPDCDIVLDHPSISRFHLEIRIIPSRRKITLTDLSSVHGT 75
FHA_ArnA-like cd22680
forkhead associated (FHA) domain found in Sulfolobus Acidocaldarius FHA domain-containing ...
34-110 1.41e-05

forkhead associated (FHA) domain found in Sulfolobus Acidocaldarius FHA domain-containing protein ArnA and similar proteins; ArnA is an FHA domain-containing protein from Sulfolobus acidocaldarius that was shown to strongly interact with ArnB, a von Willebrand domain-containing protein. They act synergistically and negatively to modulate motility. ArnA is involved in regulating archaella expression in S. acidocaldarius. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438732 [Multi-domain]  Cd Length: 96  Bit Score: 45.41  E-value: 1.41e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653   34 LHIFSGAHGPEKDFPLHLGKNVVGRMPDCSVALPFPSISKQHAEIEILawDKAPILRDCGSLNGTQI-----LRPPKVLS 108
Cdd:cd22680      3 LEILSSPNLTGKKFPFDFSSVSIGRDPENVIVIPDPFVSRNHARITVD--SNEIYIEDLGSTNGTFVndfkrIKGPAKLH 80

                   ..
gi 2462492653  109 PG 110
Cdd:cd22680     81 PN 82
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
1021-1404 1.69e-05

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 50.17  E-value: 1.69e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1021 RAAEKVSRGDQESPDACLPPTVPEAPAP-PQKPLNSQSQKHLAPPPLLSPLLPSIKPTVRKTRQDGSQEAPEAPLSSELE 1099
Cdd:PHA03307    46 DSAELAAVTVVAGAAACDRFEPPTGPPPgPGTEAPANESRSTPTWSLSTLAPASPAREGSPTPPGPSSPDPPPPTPPPAS 125
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1100 PFHPkpkirtrkssrmTPFPATSAAPEPHPSTSTAQPVTPKPTSQATRSRTNRSSVKTPEPVVPTAPELQPSTSTdqPVT 1179
Cdd:PHA03307   126 PPPS------------PAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAALPLSSPEETARAPSS--PPA 191
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1180 SEPTSQVTRGRKSRSSVKTPetvvptalELQPSTSTDRPVtSEPTSQATRGRKNRSSVKTPEPVVPTAPELQPSTSTDQP 1259
Cdd:PHA03307   192 EPPPSTPPAAASPRPPRRSS--------PISASASSPAPA-PGRSAADDAGASSSDSSSSESSGCGWGPENECPLPRPAP 262
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1260 VTSEPTYQATRGRKNRSSVKTPEPVVPTAPELRPSTSTDRPVTPKPTSRttrsRTNMSSVKTPETVVPTAPELQISTSTD 1339
Cdd:PHA03307   263 ITLPTRIWEASGWNGPSSRPGPASSSSSPRERSPSPSPSSPGSGPAPSS----PRASSSSSSSRESSSSSTSSSSESSRG 338
                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462492653 1340 QPVTPKPTSRT--TRSRTNMSSVKNPESTVPIAPELPPSTSTEQPVTPEPTSRATRGRKNRSSGKTP 1404
Cdd:PHA03307   339 AAVSPGPSPSRspSPSRPPPPADPSSPRKRPRPSRAPSSPAASAGRPTRRRARAAVAGRARRRDATG 405
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
1189-1557 1.73e-05

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 50.17  E-value: 1.73e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1189 GRKSRSSVKTPETVVPTALELQPSTSTDRPVTSEPTSQATRGRKNRSSVKTPEPVVPTAPELQPSTSTDQPVTSEPTyqA 1268
Cdd:PHA03307    38 GSQGQLVSDSAELAAVTVVAGAAACDRFEPPTGPPPGPGTEAPANESRSTPTWSLSTLAPASPAREGSPTPPGPSSP--D 115
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1269 TRGRKNRSSVKTPEPVVPTAPELR---PSTSTDRPVTPKPTSRTTRSRTNMSSVKTPETVVPTAPElqistSTDQPVTPK 1345
Cdd:PHA03307   116 PPPPTPPPASPPPSPAPDLSEMLRpvgSPGPPPAASPPAAGASPAAVASDAASSRQAALPLSSPEE-----TARAPSSPP 190
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1346 PTSRTTRSRTNMSSVKNPEStVPIAPELPPSTSTeqpvtPEPTSRATRGRKNRSSGKTPETLVPTAPKLEPSTSTDQPVT 1425
Cdd:PHA03307   191 AEPPPSTPPAAASPRPPRRS-SPISASASSPAPA-----PGRSAADDAGASSSDSSSSESSGCGWGPENECPLPRPAPIT 264
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1426 PEPTSQATRGRTNRSSVKTPETVVPTAPELQPSTSTDQPVTPEPTSQAtrgRTDRSSVKTPETVvpTAPELQASASTDQP 1505
Cdd:PHA03307   265 LPTRIWEASGWNGPSSRPGPASSSSSPRERSPSPSPSSPGSGPAPSSP---RASSSSSSSRESS--SSSTSSSSESSRGA 339
                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|..
gi 2462492653 1506 VTSEPTSRTTRGRKNRSSVKTPETVVPAAPELQPSTSTDQPVTPEPTSRATR 1557
Cdd:PHA03307   340 AVSPGPSPSRSPSPSRPPPPADPSSPRKRPRPSRAPSSPAASAGRPTRRRAR 391
PHA03369 PHA03369
capsid maturational protease; Provisional
1112-1419 3.10e-05

capsid maturational protease; Provisional


Pssm-ID: 223061 [Multi-domain]  Cd Length: 663  Bit Score: 49.23  E-value: 3.10e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1112 SSRMTPFPATSAAPEPHPSTSTAQPVTPKPTSQATRSRTNRSSVKTPEPVVPTAPELQPStSTDQPVTSEPTSQVTRGRK 1191
Cdd:PHA03369   349 KTASLTAPSRVLAAAAKVAVIAAPQTHTGPADRQRPQRPDGIPYSVPARSPMTAYPPVPQ-FCGDPGLVSPYNPQSPGTS 427
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1192 SRSSVKTPETVVPTALELQPSTSTDRPVTSEPT-SQATRGRKNRSSVKtpEPVVPTAPELQPSTSTDQPVTSEPTYQATR 1270
Cdd:PHA03369   428 YGPEPVGPVPPQPTNPYVMPISMANMVYPGHPQeHGHERKRKRGGELK--EELIETLKLVKKLKEEQESLAKELEATAHK 505
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1271 GRKNRSS--------VKTPEPVV---PTAPELRPSTSTDRPVTPKPTSRTTRSRTNMSSVKTPETVVP----TAPELQIS 1335
Cdd:PHA03369   506 SEIKKIAesefknagAKTAAANIepnCSADAAAPATKRARPETKTELEAVVRFPYQIRNMESPAFVHSftstTLAAAAGQ 585
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1336 TSTDQPVTPKPTSRTTrsrTNMSSVKNPESTVpiAPELPPSTSTEQPvTPEPTSRATRGRKNRSSGKTpETLVPTAPKLE 1415
Cdd:PHA03369   586 GSDTAEALAGAIETLL---TQASAQPAGLSLP--APAVPVNASTPAS-TPPPLAPQEPPQPGTSAPSL-ETSLPQQKPVL 658

                   ....
gi 2462492653 1416 PSTS 1419
Cdd:PHA03369   659 SKGA 662
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
1086-1432 3.43e-05

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 49.22  E-value: 3.43e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1086 SQEAPEAPLSSELEPFHPKPkirTRKSSRMTPFPATSAAPEPHPSTSTAQPVTPKPTSQATRSRTNRSSVKTPePVVPTA 1165
Cdd:TIGR00927   76 SSDPPKSSSEMEGEMLAPQA---TVGRDEATPSIAMENTPSPPRRTAKITPTTPKNNYSPTAAGTERVKEDTP-ATPSRA 151
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1166 PELQPSTSTDQPVTSepTSQVTRG-RKSRSSVKTPETVvptalelqpststdRPVTSEPtsqatRGRKNRSSVKTPEPVV 1244
Cdd:TIGR00927  152 LNHYISTSGRQRVKS--YTPKPRGeVKSSSPTQTREKV--------------RKYTPSP-----LGRMVNSYAPSTFMTM 210
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1245 PTAPELQP-STSTDQPVTSEPTYQATRGRKNRSSVKTPEPVVPTAPELRPSTSTD---------RPVTPKPTSRTTRSRT 1314
Cdd:TIGR00927  211 PRSHGITPrTTVKDSEITATYKMLETNPSKRTAGKTTPTPLKGMTDNTPTFLTREvetdlltspRSVVEKNTLTTPRRVE 290
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1315 NMSS-----------VKTPETVV----PTAPELQISTSTDQPVTPKptsrTTRSRTNMSSVKNPES-----TVPIAP--- 1371
Cdd:TIGR00927  291 SNSStnhwglvgknnLTTPQGTVlehtPATSEGQVTISIMTGSSPA----ETKASTAAWKIRNPLSrtsapAVRIASatf 366
                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462492653 1372 ---ELPPSTSTEQPVTPEPTSRATRgRKNRSSGKTPETLVPTAPklEPS-TSTDQPVTPEPTSQA 1432
Cdd:TIGR00927  367 rglEKNPSTAPSTPATPRVRAVLTT-QVHHCVVVKPAPAVPTTP--SPSlTTALFPEAPSPSPSA 428
FHA_MEK1-like cd22670
forkhead associated (FHA) domain found in Saccharomyces cerevisiae meiosis-specific serine ...
31-110 3.68e-05

forkhead associated (FHA) domain found in Saccharomyces cerevisiae meiosis-specific serine/threonine-protein kinase MEK1 and similar proteins; MEK1 (EC 2.7.11.1), also known as MRE4, is a meiosis-specific protein kinase required for chromosome synapsis and meiotic recombination. The recruitment and activation of MEK1 require the phosphorylation of the chromosome axis protein Hop1 at Thr318 (pT318), which is necessary for recognition by the MEK1 FHA domain. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438722 [Multi-domain]  Cd Length: 105  Bit Score: 44.53  E-value: 3.68e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653   31 VGRLHIFSGAhGPEKDFPLHLGKNV-VGRMPDCSVALPFPSISKQHAEIEILAWDK--API--LRDCgSLNGTQI----- 100
Cdd:cd22670      1 VGKLEVSSPG-STDIVLPIYKNQVItIGRSPSCDIVINDPFVSRTHCRIYSVQFDEssAPLvyVEDL-SSNGTYLngkli 78
                           90
                   ....*....|.
gi 2462492653  101 -LRPPKVLSPG 110
Cdd:cd22670     79 gRNNTVLLSDG 89
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
1119-1564 3.88e-05

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 48.83  E-value: 3.88e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1119 PATSAAPEPHPSTSTAQPVTPKPTSQATRSRTNRSSVKTPEPVVPTAPELQPSTSTDQPVTSEPTSQVTRGRKSRSsvkt 1198
Cdd:PRK07764   390 GAGAPAAAAPSAAAAAPAAAPAPAAAAPAAAAAPAPAAAPQPAPAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSAQ---- 465
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1199 petvvPTALELQPSTSTDRPVTSEPTSQATrgrknrssvkTPEPVVPTAPELQPSTSTDQPVTSE-PTYQATRGRKNRSS 1277
Cdd:PRK07764   466 -----PAPAPAAAPEPTAAPAPAPPAAPAP----------AAAPAAPAAPAAPAGADDAATLRERwPEILAAVPKRSRKT 530
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1278 --VKTPEPVVPtapELRPSTSTdrpvtpkPTSRTTRSRTNMSSVKTPETVVpTApelqISTSTDQPVTPKPTSRTTRSRT 1355
Cdd:PRK07764   531 waILLPEATVL---GVRGDTLV-------LGFSTGGLARRFASPGNAEVLV-TA----LAEELGGDWQVEAVVGPAPGAA 595
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1356 NMSSVKNPESTVPI--APELPPSTSTEQPVTPEPTSRATRGRKNRSSGKTPETLVPTAPKLEPSTSTDQPVTPEPTSQAT 1433
Cdd:PRK07764   596 GGEGPPAPASSGPPeeAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGG 675
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1434 RGRTNRSSVKTPETVVPTAPELQPSTSTDQPVTPePTSQATRGRTDRSSVKTpetvvpTAPELQASASTDQPVTSEPTSR 1513
Cdd:PRK07764   676 AAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATP-PAGQADDPAAQPPQAAQ------GASAPSPAADDPVPLPPEPDDP 748
                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2462492653 1514 TTRGRKNRSSVKTPETVVPAAP--ELQPSTSTDQPVTPEPTSRATRGRTNRSS 1564
Cdd:PRK07764   749 PDPAGAPAQPPPPPAPAPAAAPaaAPPPSPPSEEEEMAEDDAPSMDDEDRRDA 801
FHA_AGGF1 cd22686
forkhead associated (FHA) domain found in angiogenic factor with G patch and FHA domains 1 ...
25-132 2.84e-04

forkhead associated (FHA) domain found in angiogenic factor with G patch and FHA domains 1 (AGGF1) and similar proteins; AGGF1, also called angiogenic factor VG5Q, or G patch domain-containing protein 7 (GPATC7), or vasculogenesis gene on 5q protein, is an angiogenic factor involved in vascular development, angiogenesis, specification of hemangioblasts, and differentiation of veins. It promotes angiogenesis and the proliferation of endothelial cells. It inhibits inflammatory effect and preserve vascular integrity in non-nervous system diseases. Mutated AGGF1 causes susceptibility to Klippel-Trenaunay syndrome, a vascular disorder. Increased AGGF1 expression is associated with tumor angiogenesis. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438738 [Multi-domain]  Cd Length: 123  Bit Score: 42.65  E-value: 2.84e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653   25 RCNVEPVGRLHIFS--GAhgpekdfplhlgknVVGRMPDCSVALPFP--SISKQHAEIEILAWDKAPILRDCGS-----L 95
Cdd:cd22686     11 ESPSLQVGSLFIVTatGA--------------TIGREKDHGHTIRIPelGVSKFHAEIYYDDDEQSYTIVDLGSqngtyL 76
                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 2462492653   96 NGTQILRPPKVLSP-GVSHrlRDQELILFADLLCQYHR 132
Cdd:cd22686     77 NGVRISQPKEKSDPyPLTH--GDELKIGETTLLFHIHP 112
Pneumo_att_G pfam05539
Pneumovirinae attachment membrane glycoprotein G;
1140-1308 3.68e-04

Pneumovirinae attachment membrane glycoprotein G;


Pssm-ID: 114270 [Multi-domain]  Cd Length: 408  Bit Score: 45.42  E-value: 3.68e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1140 KPTSQATRSRTNRSSVKTPEPVVPT--APELQPSTSTDQPVTSEPTSQVT---RGRKSRSSVKTPETVVPTALELQPSTS 1214
Cdd:pfam05539  167 EPKTAVTTSKTTSWPTEVSHPTYPSqvTPQSQPATQGHQTATANQRLSSTepvGTQGTTTSSNPEPQTEPPPSQRGPSGS 246
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1215 TDRPVTSEPTSQATRGRKNRSsvkTPEPVVPTAPElqPSTSTDQPVTSEPTYQATRGRKnrssvKTPEPVVPTAPELRPS 1294
Cdd:pfam05539  247 PQHPPSTTSQDQSTTGDGQEH---TQRRKTPPATS--NRRSPHSTATPPPTTKRQETGR-----PTPRPTATTQSGSSPP 316
                          170
                   ....*....|....
gi 2462492653 1295 TSTDRPVTPKPTSR 1308
Cdd:pfam05539  317 HSSPPGVQANPTTQ 330
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
1112-1303 4.68e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 45.36  E-value: 4.68e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1112 SSRMTPFPATSAAPEPHPSTSTAQPVTPKPTSQATRSRtnrssvktpEPVVPTAPELQPSTSTDQPVTSEPTSQVTRGRK 1191
Cdd:PRK07764   600 PPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPA---------EASAAPAPGVAAPEHHPKHVAVPDASDGGDGWP 670
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1192 SRSSVKTPETVVPTALELQPSTSTDRPVTSEPTSQATRGRKNRSSVKTPEPVVPTAPELQPSTSTD--QPVTSEPTYQAT 1269
Cdd:PRK07764   671 AKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADdpVPLPPEPDDPPD 750
                          170       180       190
                   ....*....|....*....|....*....|....*.
gi 2462492653 1270 RGRKNRSSVKTPEPVVPTAP--ELRPSTSTDRPVTP 1303
Cdd:PRK07764   751 PAGAPAQPPPPPAPAPAAAPaaAPPPSPPSEEEEMA 786
PHA03255 PHA03255
BDLF3; Provisional
1470-1629 5.59e-04

BDLF3; Provisional


Pssm-ID: 165513 [Multi-domain]  Cd Length: 234  Bit Score: 43.74  E-value: 5.59e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1470 TSQATRGRTDRSSVKTPETVVPTAPELQASASTDQPVTSEPTSRTTRGRKNRSSVKTPETVVPAAPelqpstSTDQPVTP 1549
Cdd:PHA03255    27 SGSSTASAGNVTGTTAVTTPSPSASGPSTNQSTTLTTTSAPITTTAILSTNTTTVTSTGTTVTPVP------TTSNASTI 100
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1550 EPTSRATRGRTNRSSVKTPESivpiapelQPSTSRNQLVTPEPTSRATRCRTNRSSVKTPEPV-----------VPTAP- 1617
Cdd:PHA03255   101 NVTTKVTAQNITATEAGTGTS--------TGVTSNVTTRSSSTTSATTRITNATTLAPTLSSKgtsnatkttaeLPTVPd 172
                          170
                   ....*....|..
gi 2462492653 1618 EPHPTTSTDQPV 1629
Cdd:PHA03255   173 ERQPSLSYGLPL 184
FHA_EspA-like cd22698
forkhead associated (FHA) domain found in Myxococcus xanthus EspA and similar proteins; EspA ...
42-100 5.83e-04

forkhead associated (FHA) domain found in Myxococcus xanthus EspA and similar proteins; EspA is a histidine protein kinase with a fork head-associated (FHA) domain at the N-terminus and a receiver domain at the C-terminus. It functions as an inhibitor of sporulation during early fruiting body development while cells are aggregating into raised mounds. EspA is part of a two-component signal transduction system that regulates the timing of sporulation initiation. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438750 [Multi-domain]  Cd Length: 93  Bit Score: 40.86  E-value: 5.83e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462492653   42 GPEKDFPLHL--GKNVVGRMPDCSVALPFPSISKQHAEIEiLAWDKApILRDCGSLNGTQI 100
Cdd:cd22698      9 GSEEGKDYELdqDEFTIGRSSNNDIRLNDHSVSRHHARIV-RQGDKC-NLTDLGSTNGTFL 67
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
947-1350 6.57e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 45.14  E-value: 6.57e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653  947 QRGEPEGGSQDQKGQASSPTPEPGVGAGDLPGPTSAPVPSGSQSGGRGSPVSPRRHQKGLLNCKMPPAEKASRIRAAEKV 1026
Cdd:pfam03154  152 QDNESDSDSSAQQQILQTQPPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTLI 231
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1027 SRGDQESPDACLPPTVPEAPAPPQKPLNSQSQKHLAPPPLLSPLlpsikPTVRKTRQDGSQEAPEAPlsselePFHPKPK 1106
Cdd:pfam03154  232 QQTPTLHPQRLPSPHPPLQPMTQPPPPSQVSPQPLPQPSLHGQM-----PPMPHSLQTGPSHMQHPV------PPQPFPL 300
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1107 IRTRKSSRMTPFPATSAapePHPSTSTAQpvTPKPTSQATRSRTNRSSVKTPEPVvpTAPELQPSTSTDQPVTSEPTSQV 1186
Cdd:pfam03154  301 TPQSSQSQVPPGPSPAA---PGQSQQRIH--TPPSQSQLQSQQPPREQPLPPAPL--SMPHIKPPPTTPIPQLPNPQSHK 373
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1187 TRGRKSRSSVKTPETVVPTALELQP--STSTDRPVTSEP-------TSQATRGRKNRSSVKTPEPVVPTAPELQPSTSTD 1257
Cdd:pfam03154  374 HPPHLSGPSPFQMNSNLPPPPALKPlsSLSTHHPPSAHPpplqlmpQSQQLPPPPAQPPVLTQSQSLPPPAASHPPTSGL 453
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1258 QPVTSEPTYqatrgrknrssvkTPEPVVPTAPELRPSTSTDRPVTPK--PTSRTTRSRTNMSSVKTPETVVPTAPELQIS 1335
Cdd:pfam03154  454 HQVPSQSPF-------------PQHPFVPGGPPPITPPSGPPTSTSSamPGIQPPSSASVSSSGPVPAAVSCPLPPVQIK 520
                          410
                   ....*....|....*....
gi 2462492653 1336 T----STDQPVTPKPTSRT 1350
Cdd:pfam03154  521 EealdEAEEPESPPPPPRS 539
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
1089-1312 7.38e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 44.84  E-value: 7.38e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1089 APEAPLSSELEPFHPKPKIRTRKSSRMTPFPATSAAPEPhPSTSTAQPVTPKPTSQATRSRTNRSSVKTPEPVvPTAPEL 1168
Cdd:PRK07003   384 GARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATR-AEAPPAAPAPPATADRGDDAADGDAPVPAKANA-RASADS 461
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1169 QPSTSTDQPVTSEPTSQVTRGRKSRSSVKTPEtvvPTALELQPSTSTDRPVTSEPTSQATRGRknrssvktPEPVVPTAP 1248
Cdd:PRK07003   462 RCDERDAQPPADSGSASAPASDAPPDAAFEPA---PRAAAPSAATPAAVPDARAPAAASREDA--------PAAAAPPAP 530
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462492653 1249 ELQPSTstdqPVTSEPTYQAT--------------RGRKNRSSVKTPEPVVPTAPELRPSTSTDRPVTPKPTSRTTRS 1312
Cdd:PRK07003   531 EARPPT----PAAAAPAARAGgaaaaldvlrnagmRVSSDRGARAAAAAKPAAAPAAAPKPAAPRVAVQVPTPRARAA 604
Yop-YscD_cpl pfam16697
Inner membrane component of T3SS, cytoplasmic domain; Yop-YscD-cpl is the cytoplasmic domain ...
36-119 7.76e-04

Inner membrane component of T3SS, cytoplasmic domain; Yop-YscD-cpl is the cytoplasmic domain of Yop proteins like YscD from Proteobacteria. YscD forms part of the inner membrane component of the bacterial type III secretion injectosome apparatus.


Pssm-ID: 465238 [Multi-domain]  Cd Length: 94  Bit Score: 40.71  E-value: 7.76e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653   36 IFSGAH-GpeKDFPLHLGKNVVGRMPDCSVALPFPSISKQHAEIEILA--WdkapILRDCGSLNGT-----------QIL 101
Cdd:pfam16697    2 VLSGPHaG--AEFPLEGGRYRIGSDPDCDIVLSDKEVSRVHLKLEVDDegW----RLDDLGSGNGTlvngqrvtelgIAL 75
                           90
                   ....*....|....*....
gi 2462492653  102 RPPKVLSPGVSH-RLRDQE 119
Cdd:pfam16697   76 RPGDRIELGQTEfCLVPAD 94
motB PRK12799
flagellar motor protein MotB; Reviewed
1333-1472 7.82e-04

flagellar motor protein MotB; Reviewed


Pssm-ID: 183756 [Multi-domain]  Cd Length: 421  Bit Score: 44.32  E-value: 7.82e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1333 QISTSTDQPVTPKPTSrttrSRTNMSSVKNPESTVPIAPELPPSTSTEQPVTPEPTSRATRGRKNRSSGKTPETLVPTAP 1412
Cdd:PRK12799   292 QIDTHGTVPVAAVTPS----SAVTQSSAITPSSAAIPSPAVIPSSVTTQSATTTQASAVALSSAGVLPSDVTLPGTVALP 367
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1413 KLEPSTSTDQPVTPEPTSQATRGRTNRSSvKTPETVVPTAPelqpststDQPVTPEPTSQ 1472
Cdd:PRK12799   368 AAEPVNMQPQPMSTTETQQSSTGNITSTA-NGPTTSLPAAP--------ASNIPVSPTSR 418
DUF612 pfam04747
Protein of unknown function, DUF612; This family includes several uncharacterized proteins ...
1370-1661 8.36e-04

Protein of unknown function, DUF612; This family includes several uncharacterized proteins from Caenorhabditis elegans.


Pssm-ID: 282585 [Multi-domain]  Cd Length: 511  Bit Score: 44.28  E-value: 8.36e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1370 APELPPSTSTEQPVTPEPTSRATRGRKNRSSGKTPETLVPTAP-KLEPSTSTDQPVTPEPTSQAT--RGRTNRSSVKTPE 1446
Cdd:pfam04747  189 APAPEPKTPTNTPAEPAEQVQEITGKKNKKNKKKSESEATAAPaSVEQVVEQPKVVTEEPHQQAApqEKKNKKNKRKSES 268
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1447 TVVPTAPE--LQPSTSTDQPVTPEPTSQATRGRTDRSSVKTPETVVPTAPELQASASTDQPVTSEPTsrTTRGRKNRSSV 1524
Cdd:pfam04747  269 ENVPAASEtpVEPVVETTPPASENQKKNKKDKKKSESEKVVEEPVQAEAPKSKKPTADDNMDFLDFV--TAKEEPKDEPA 346
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1525 KTPETVVPAAPELQPSTSTDQPVTPEPTSRATRGRTNRSSVKT------PESIVPIAPELQPSTSRNQLVTPEPTSRATR 1598
Cdd:pfam04747  347 ETPAAPVEEVVENVVENVVEKSTTPPATENKKKNKKDKKKSESekvteqPVESAPAPPQVEQVVETTPPASENKKKNKKD 426
                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462492653 1599 CRTNRSSVKTPEPVVPTAPEPHPTTSTDQPVTPKLTSRATRRKTNRSSVKTPKPVEPAASDLE 1661
Cdd:pfam04747  427 KKKSESEKAVEEPVQAAPSSKKPTADDNMDFLDFVTAKPDKSESVEEHIAAPMIVEPAHADEE 489
PLN03209 PLN03209
translocon at the inner envelope of chloroplast subunit 62; Provisional
1443-1664 1.10e-03

translocon at the inner envelope of chloroplast subunit 62; Provisional


Pssm-ID: 178748 [Multi-domain]  Cd Length: 576  Bit Score: 44.15  E-value: 1.10e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1443 KTPETVVPTAPELQPSTSTDQPVTPEPTSQATRG---RTDRSSVKTPETVVPTAPELQASASTDQPVTSEPTSRTTrgrk 1519
Cdd:PLN03209   337 DGPKPVPTKPVTPEAPSPPIEEEPPQPKAVVPRPlspYTAYEDLKPPTSPIPTPPSSSPASSKSVDAVAKPAEPDV---- 412
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1520 nrSSVKTPETVVPAAPELQPSTSTDQPVTP--------EPTSRATRGRTNRSSVKTPESIVPIAPELQPSTSRNQLVTPE 1591
Cdd:PLN03209   413 --VPSPGSASNVPEVEPAQVEAKKTRPLSPyaryedlkPPTSPSPTAPTGVSPSVSSTSSVPAVPDTAPATAATDAAAPP 490
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462492653 1592 PT-SRATRCRTNRSSVKTPEPVVPTAPEPHPTTSTDQPVTPKLTSRATRRKTNRSSVKTPKPvepaaSDLEPFT 1664
Cdd:PLN03209   491 PAnMRPLSPYAVYDDLKPPTSPSPAAPVGKVAPSSTNEVVKVGNSAPPTALADEQHHAQPKP-----RPLSPYT 559
PRK13914 PRK13914
invasion associated endopeptidase;
1252-1452 1.29e-03

invasion associated endopeptidase;


Pssm-ID: 237555 [Multi-domain]  Cd Length: 481  Bit Score: 43.64  E-value: 1.29e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1252 PSTSTDQPVTSEPTYQATRGRKNRSSVKTPEPVVPTAPelRPSTSTDRPVTPK-PTSRTTRSR----------------- 1313
Cdd:PRK13914   147 PVAPTQEVKKETTTQQAAPAAETKTEVKQTTQATTPAP--KVAETKETPVVDQnATTHAVKSGdtiwalsvkygvsvqdi 224
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1314 ---TNMSS--------VKTPETVVPTAPELQisTSTDQPVTPKPTSRTTRSRTNMSSVKNPESTVPIAPELPPSTSTE-- 1380
Cdd:PRK13914   225 mswNNLSSssiyvgqkLAIKQTANTATPKAE--VKTEAPAAEKQAAPVVKENTNTNTATTEKKETTTQQQTAPKAPTEaa 302
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462492653 1381 QPvTPEPTSRATRGRKNRSSGKTPETLVPTAPKLEPSTSTDQPVTPEPTSQATRGRTNRSSVKTPETVVPTA 1452
Cdd:PRK13914   303 KP-APAPSTNTNANKTNTNTNTNTNNTNTSTPSKNTNTNTNSNTNTNSNTNANQGSSNNNSNSSASAIIAEA 373
FHA_Cep170 cd22704
forkhead associated (FHA) domain found in the centrosomal protein of 170 kDa protein (Cep170) ...
56-98 1.31e-03

forkhead associated (FHA) domain found in the centrosomal protein of 170 kDa protein (Cep170) family; The Cep170 family includes Cep170 and Cep170B. Cep170, also called Cep170A, KARP-1-binding protein, or KARP1-binding protein, is a protein that localizes to centrosomes as well as spindle microtubules and plays a role in microtubule organization and microtubule assembly. It is required for centriole subdistal appendage assembly. Cep170 is phosphorylated during M phase and interacts with Polo-like kinase 1 (Plk1). Cep170B, also called centrosomal protein 170B, plays a role in microtubule organization. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438756 [Multi-domain]  Cd Length: 102  Bit Score: 40.00  E-value: 1.31e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 2462492653   56 VGRmPDCSVALPFPSISKQHAEIEILAWDKAPILRDCGSLNGT 98
Cdd:cd22704     21 VGR-EDCDLILQSRSVDKQHAVITYDQIDNEFKIKDLGSLNGT 62
DUF4775 pfam16001
Domain of unknown function (DUF4775); This family of proteins is functionally uncharacterized. ...
1189-1512 1.40e-03

Domain of unknown function (DUF4775); This family of proteins is functionally uncharacterized. This family of proteins is found in eukaryotes. Proteins in this family are typically between 308 and 484 amino acids in length.


Pssm-ID: 406411 [Multi-domain]  Cd Length: 456  Bit Score: 43.57  E-value: 1.40e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1189 GRKSRSSVKTPETVVPTALELQPSTSTDRPVTSEPTSQATRGRKNRS-SVKTPEPVVPTAPELQPSTSTDQPV-----TS 1262
Cdd:pfam16001   30 GRRTRSSTRGTPTRSAETVTPPPSKKARTSPATATKSSGGKGRGARKlDVGAEEPVEQETKKKKKVQNEPEAKeekekVS 109
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1263 EPTYQATRGRKNRSSVKTPEPVVPTAPELRPSTSTDRPVTPKPTSRTTRSRTNMSSVKTPET-VVPTAPE-LQISTSTDQ 1340
Cdd:pfam16001  110 EPVKGKPAAKKEKKEEKKQKKKEADEKEVVEEKEKEDKEEEKTETKETDAKTAESKDQPDGVgQLPAVAEeKQNHVDEDK 189
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1341 PVTPKPTSR------TTRSRTNMSSVKNPEST-VPIAPELPPST------STEQPVTPEPTSRATRGRKNRSSGKTPETL 1407
Cdd:pfam16001  190 PETEEPEEKektpeeVAKAEEPPKTSENGAATdTPAAVPESESAmevdeeEKLQENTPQATADAPSDDKAVPDIKVEEKV 269
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1408 VPTAPKLEPSTSTDQPV---TPEPTSQATrgrTNRSSVKTPETVVPTAPELQPSTSTDQPVTPEPTSQATRGRTDRSSVK 1484
Cdd:pfam16001  270 AAVSESSEEPKETSEPAkepTPEPMEVDS---SSKGSSDTAQVDTPVKEVVPAAPATESAVAAESTEASNSNNEVVEVAT 346
                          330       340
                   ....*....|....*....|....*...
gi 2462492653 1485 TPETVVPTAPELQASASTDQPVTSEPTS 1512
Cdd:pfam16001  347 EVKEDVPEVPPKEAESSEEPAKEAESTT 374
motB PRK12799
flagellar motor protein MotB; Reviewed
1413-1554 1.48e-03

flagellar motor protein MotB; Reviewed


Pssm-ID: 183756 [Multi-domain]  Cd Length: 421  Bit Score: 43.17  E-value: 1.48e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1413 KLEPSTSTDQPVTPEPTSQATRGRTNRSSVKTPETVVPTAPELQPSTSTDQPVTPEPTSQATRGRTDRSSVKTPETVVPT 1492
Cdd:PRK12799   286 KATGLKQIDTHGTVPVAAVTPSSAVTQSSAITPSSAAIPSPAVIPSSVTTQSATTTQASAVALSSAGVLPSDVTLPGTVA 365
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462492653 1493 APELQASASTDQPVTSEPTSRTTRGRKNRSSvKTPETVVPAAPelqpststDQPVTPEPTSR 1554
Cdd:PRK12799   366 LPAAEPVNMQPQPMSTTETQQSSTGNITSTA-NGPTTSLPAAP--------ASNIPVSPTSR 418
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
1076-1482 1.53e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 43.82  E-value: 1.53e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1076 PTVRKTRQDGSQEAPEAPlsselEPFHPKPKIRTRKSSRMTPFPATSAAPEPHPSTSTAQPVTPKPTSQATRSRTNRSSV 1155
Cdd:PRK07764   418 AAAAAPAPAAAPQPAPAP-----APAPAPPSPAGNAPAGGAPSPPPAAAPSAQPAPAPAAAPEPTAAPAPAPPAAPAPAA 492
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1156 KTPEPVVPTAPELQPSTSTDQPVTSEPTSQVTRGRKSRSSVKTPETVV----PTALELQPSTSTDR-----PVTSEPTSQ 1226
Cdd:PRK07764   493 APAAPAAPAAPAGADDAATLRERWPEILAAVPKRSRKTWAILLPEATVlgvrGDTLVLGFSTGGLArrfasPGNAEVLVT 572
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1227 ATRGRKNRssVKTPEPVVPTAPELQPSTSTDQPVTSEPTYQATRgrknrssvktpepvvPTAPElrpstSTDRPVTPKPT 1306
Cdd:PRK07764   573 ALAEELGG--DWQVEAVVGPAPGAAGGEGPPAPASSGPPEEAAR---------------PAAPA-----APAAPAAPAPA 630
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1307 SRTTRSRTNMSSVKTPETVVPTAPELQISTSTDQPVTPKPTSRTTRSrtnmssvknPESTVPIAPELPPSTSTEQPVTPE 1386
Cdd:PRK07764   631 GAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAA---------PAAPPPAPAPAAPAAPAGAAPAQP 701
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1387 PTSRATRGRKNRSSGKTPETLVPTAPKLEPSTSTD--QPVTPEPTSQATRGRTNRSSVKTPETVVPTAP--ELQPSTSTD 1462
Cdd:PRK07764   702 APAPAATPPAGQADDPAAQPPQAAQGASAPSPAADdpVPLPPEPDDPPDPAGAPAQPPPPPAPAPAAAPaaAPPPSPPSE 781
                          410       420
                   ....*....|....*....|
gi 2462492653 1463 QPVTPEPTSQATRGRTDRSS 1482
Cdd:PRK07764   782 EEEMAEDDAPSMDDEDRRDA 801
motB PRK12799
flagellar motor protein MotB; Reviewed
1103-1217 1.90e-03

flagellar motor protein MotB; Reviewed


Pssm-ID: 183756 [Multi-domain]  Cd Length: 421  Bit Score: 43.17  E-value: 1.90e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1103 PKPKIRTRKSSRMTPFPATSAAPEPHPSTSTAQPVTPKPTSQATRSRTNRSSVKTPEPVVPTAPELQPSTSTDQPVTSEP 1182
Cdd:PRK12799   304 VTPSSAVTQSSAITPSSAAIPSPAVIPSSVTTQSATTTQASAVALSSAGVLPSDVTLPGTVALPAAEPVNMQPQPMSTTE 383
                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 2462492653 1183 TSQVTRGrKSRSSVKTPETVVPTALELQ-PSTSTDR 1217
Cdd:PRK12799   384 TQQSSTG-NITSTANGPTTSLPAAPASNiPVSPTSR 418
COG3456 COG3456
Predicted component of the type VI protein secretion system, contains a FHA domain [Signal ...
55-126 1.99e-03

Predicted component of the type VI protein secretion system, contains a FHA domain [Signal transduction mechanisms, Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 442679 [Multi-domain]  Cd Length: 402  Bit Score: 42.83  E-value: 1.99e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462492653   55 VVGRMPDCSVALPFPS--ISKQHAEIEILawDKAPILRDCgSLNGTQILRPPKVLSPGVSHRLRDQELILFADL 126
Cdd:COG3456     29 TIGRSADCDWVLPDPDrsVSRRHAEIRFR--DGAFCLTDL-STNGTFLNGSDHPLGPGRPVRLRDGDRLRIGDY 99
PRK10263 PRK10263
DNA translocase FtsK; Provisional
1036-1547 2.08e-03

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 43.54  E-value: 2.08e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1036 ACLPPTVPEAPAPPQKPLNSQSQKHLAPPPLLSPLLPSIKPTVRKTRQDGSQEAPEAPLSSELE-PFHPKPKIRTRKSSR 1114
Cdd:PRK10263   335 APVEPVTQTPPVASVDVPPAQPTVAWQPVPGPQTGEPVIAPAPEGYPQQSQYAQPAVQYNEPLQqPVQPQQPYYAPAAEQ 414
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1115 MTPFPATSAAPEPHPSTSTAQPVTPKPTSQATRSRTNRSSVKTP-----------EPVVPTAPELQPStSTDQPVTSEPT 1183
Cdd:PRK10263   415 PAQQPYYAPAPEQPAQQPYYAPAPEQPVAGNAWQAEEQQSTFAPqstyqteqtyqQPAAQEPLYQQPQ-PVEQQPVVEPE 493
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1184 SQVTRGRKSRSSVKTPETVVPT-ALELQPSTSTDRPVtSEPtsqatrgrknrssVKTPEPVVPTAPelQPSTSTDQPVTS 1262
Cdd:PRK10263   494 PVVEETKPARPPLYYFEEVEEKrAREREQLAAWYQPI-PEP-------------VKEPEPIKSSLK--APSVAAVPPVEA 557
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1263 EPTYQATRGRKNRSSVKTPEPVVPTAPELRPSTS-TDRPVT--------PKPTSRTTRSRTNMSS--VKTPETVV----- 1326
Cdd:PRK10263   558 AAAVSPLASGVKKATLATGAAATVAAPVFSLANSgGPRPQVkegigpqlPRPKRIRVPTRRELASygIKLPSQRAaeeka 637
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1327 ------PTAPELQISTSTDQPVTPKPTSRTTRSRTNMSSVKNPESTVPIAPELPPSTSTEQPVTPEPTSRATRGRKNRSS 1400
Cdd:PRK10263   638 reaqrnQYDSGDQYNDDEIDAMQQDELARQFAQTQQQRYGEQYQHDVPVNAEDADAAAEAELARQFAQTQQQRYSGEQPA 717
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1401 GKTPETL--------------VPTAPKLEPS-----TSTDQPVTPEPTSQATRGRTNRSSVKTPETVVPTAPELQpstST 1461
Cdd:PRK10263   718 GANPFSLddfefspmkallddGPHEPLFTPIvepvqQPQQPVAPQQQYQQPQQPVAPQPQYQQPQQPVAPQPQYQ---QP 794
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1462 DQPVTPEPTSQATRGRT-DRSSVKTPETVVPTAPELQASASTDQPVTSEPTSRTTRGRKNRSS-VKTPETVVPAAPELQP 1539
Cdd:PRK10263   795 QQPVAPQPQYQQPQQPVaPQPQYQQPQQPVAPQPQYQQPQQPVAPQPQDTLLHPLLMRNGDSRpLHKPTTPLPSLDLLTP 874

                   ....*...
gi 2462492653 1540 STSTDQPV 1547
Cdd:PRK10263   875 PPSEVEPV 882
motB PRK12799
flagellar motor protein MotB; Reviewed
1382-1513 2.14e-03

flagellar motor protein MotB; Reviewed


Pssm-ID: 183756 [Multi-domain]  Cd Length: 421  Bit Score: 42.78  E-value: 2.14e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1382 PVTPEPTSRATrgrkNRSSGKTPETLVPTAPKLEPSTSTDQPVTPEPTSQATRGRTNRSSVKTPETVVPTAPELQPSTST 1461
Cdd:PRK12799   300 PVAAVTPSSAV----TQSSAITPSSAAIPSPAVIPSSVTTQSATTTQASAVALSSAGVLPSDVTLPGTVALPAAEPVNMQ 375
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 2462492653 1462 DQPVTPEPTSQATRGRTDRSSvKTPETVVPTAPELQASAStdqpvtsePTSR 1513
Cdd:PRK12799   376 PQPMSTTETQQSSTGNITSTA-NGPTTSLPAAPASNIPVS--------PTSR 418
PLN03209 PLN03209
translocon at the inner envelope of chloroplast subunit 62; Provisional
1293-1542 2.24e-03

translocon at the inner envelope of chloroplast subunit 62; Provisional


Pssm-ID: 178748 [Multi-domain]  Cd Length: 576  Bit Score: 42.99  E-value: 2.24e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1293 PSTSTDRPVTPKPTSRTTRSRTNMSSVKTPETVVPTAPELQISTSTDQPVTPKPTS-RTTRSRTNMSSVKNPESTVPIap 1371
Cdd:PLN03209   312 PLTPMEELLAKIPSQRVPPKESDAADGPKPVPTKPVTPEAPSPPIEEEPPQPKAVVpRPLSPYTAYEDLKPPTSPIPT-- 389
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1372 elPPSTSTEQPVTPEPTSRATRGRKNRSSGKT---PETLVPTAPK-----LEPSTSTDQ---PVTPEPTSQATRGRTNRS 1440
Cdd:PLN03209   390 --PPSSSPASSKSVDAVAKPAEPDVVPSPGSAsnvPEVEPAQVEAkktrpLSPYARYEDlkpPTSPSPTAPTGVSPSVSS 467
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1441 S---VKTPETVVPTA--PELQPSTSTDQPVTPEPTSQATRGRTDRSSVKTPETVVPTAPELQASASTDQPVTSEPTSRTT 1515
Cdd:PLN03209   468 TssvPAVPDTAPATAatDAAAPPPANMRPLSPYAVYDDLKPPTSPSPAAPVGKVAPSSTNEVVKVGNSAPPTALADEQHH 547
                          250       260
                   ....*....|....*....|....*..
gi 2462492653 1516 RGRKNRssvktPETVVPAAPELQPSTS 1542
Cdd:PLN03209   548 AQPKPR-----PLSPYTMYEDLKPPTS 569
FHA_SNIP1_DDL-like cd22676
forkhead associated (FHA) domain found in Smad nuclear-interacting protein 1 (SNIP1), FHA ...
33-124 2.30e-03

forkhead associated (FHA) domain found in Smad nuclear-interacting protein 1 (SNIP1), FHA domain-containing protein DDL, and similar proteins; SNIP1 is an FHA domain-containing protein required for pre-mRNA splicing as a component of the spliceosome. It inhibits NF-kappaB signaling by competing for its binding to the C/H1 domain of CBP/p300 transcriptional co-activators. It is involved in microRNA (miRNA) biogenesis. SNIP1 is a regulator of the cell cycle and cyclin D1 expression and may be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. This family also includes Arabidopsis thaliana FHA domain-containing protein DDL and similar proteins. DDL, also called protein DAWDLE, is involved in the microRNA (miRNA) and short interfering RNA (siRNA) biogenesis. It may facilitate DCL1 to access or recognize primary miRNAs. DDL binds RNA non-specifically. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438728 [Multi-domain]  Cd Length: 111  Bit Score: 39.59  E-value: 2.30e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653   33 RLHIFSGAHGPEkdfPLHLGKN---VVGRMPD-CSVALPFPSISKQHAEIEILAWDK----------APILRDCGSLNGT 98
Cdd:cd22676      2 RLYVFKGGEQLE---TIDIHRQsayLIGRDRRvADIPLDHPSCSKQHAVIQFREVEKrnegdvieniRPYIIDLGSTNGT 78
                           90       100
                   ....*....|....*....|....*.
gi 2462492653   99 QILRPPkvLSPGVSHRLRDQELILFA 124
Cdd:cd22676     79 FLNGEK--IEPRRYYELREKDVLKFG 102
PRK07994 PRK07994
DNA polymerase III subunits gamma and tau; Validated
1101-1290 2.39e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236138 [Multi-domain]  Cd Length: 647  Bit Score: 42.93  E-value: 2.39e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1101 FHPKPKIRTRKSSRMTPFPATSAAPEPHPSTSTAQPVTPKPTSQatrsrtnrssvktPEPVVPTAPELQPSTSTDQPvtS 1180
Cdd:PRK07994   359 FHPAAPLPEPEVPPQSAAPAASAQATAAPTAAVAPPQAPAVPPP-------------PASAPQQAPAVPLPETTSQL--L 423
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1181 EPTSQVTRgRKSRSSVKTPETVVPTALELQPStSTDRPVTSEPTSQATrgrknrssvkTPEPVVPTAPELQPSTSTDQPV 1260
Cdd:PRK07994   424 AARQQLQR-AQGATKAKKSEPAAASRARPVNS-ALERLASVRPAPSAL----------EKAPAKKEAYRWKATNPVEVKK 491
                          170       180       190
                   ....*....|....*....|....*....|
gi 2462492653 1261 TSEPTYQATrgRKNRSSVKTPEPVVPTAPE 1290
Cdd:PRK07994   492 EPVATPKAL--KKALEHEKTPELAAKLAAE 519
Agg_substance NF033875
LPXTG-anchored aggregation substance; Aggregation substances, as described in Enterococcus, ...
1452-1583 2.52e-03

LPXTG-anchored aggregation substance; Aggregation substances, as described in Enterococcus, are LPXTG-anchored large surface proteins that contribute to virulence. Several closely related paralogs may be found in a single strain.


Pssm-ID: 411439 [Multi-domain]  Cd Length: 1306  Bit Score: 43.16  E-value: 2.52e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1452 APEL--QPSTSTDQPVTPEPTSQATrgrtdrssvkTPETVVPTAPELQASaSTDQPVTSEPTSRTTRGRKNRSSVKTPET 1529
Cdd:NF033875    43 AAELdtQPGTTTVQPDNPDPQSGSE----------TPKTAVSEEATVQKD-TTSQPTKVEEVASEKNGAEQSSATPNDTT 111
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2462492653 1530 VVPAAPELQPSTSTDQPVTPEPTSRATRGRtnrssvktPESIVPIAPELQPSTS 1583
Cdd:NF033875   112 NAQQPTVGAEKSAQEQPVVSPETTNEPLGQ--------PTEVAPAENEANKSTS 157
rne PRK10811
ribonuclease E; Reviewed
840-1333 2.59e-03

ribonuclease E; Reviewed


Pssm-ID: 236766 [Multi-domain]  Cd Length: 1068  Bit Score: 43.10  E-value: 2.59e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653  840 PERQTDVTGEEELTKGKQDREQKqllaRDTQRQESDKNGESASPERDRESLKVEIETSEEIQEKQVQKQtlpskaferev 919
Cdd:PRK10811   583 GEETKPQEQPAPKAEAKPERQQD----RRKPRQNNRRDRNERRDTRDNRTRREGRENREENRRNRRQAQ----------- 647
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653  920 ERPVANRECDPAELEEKVPKVILERDTQRGEPEGGSQDQKGQASSPTPEPgvgagdlpgPTSAPVPSGSQSGGRGSPVSP 999
Cdd:PRK10811   648 QQTAETRESQQAEVTEKARTQDEQQQAPRRERQRRRNDEKRQAQQEAKAL---------NVEEQSVQETEQEERVQQVQP 718
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1000 RRHQKGLlnckmppaEKASRIRAAEKVSRGDQESPDACLPPTVPEAPAPPQKPLNSQSQKhlapppllspllpSIKPTVR 1079
Cdd:PRK10811   719 RRKQRQL--------NQKVRIEQSVAEEAVAPVVEETVAAEPVVQEVPAPRTELVKVPLP-------------VVAQTAP 777
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1080 KTRQDGSQEAPEA---PLSSELEPFHPKPKIRTRKSSR------MTPFPATSAAPEPHPSTS---TAQPVTPKPTSQATR 1147
Cdd:PRK10811   778 EQDEENNAENRDNngmPRRSRRSPRHLRVSGQRRRRYRderyptQSPMPLTVACASPEMASGkvwIRYPVVRPQDVQVEE 857
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1148 SRTNRSSVKTP---EPVVPTAPELQPSTSTDQPVTSEPTSQVTRGRKSRSSVKTPETVVPTALElQPSTSTDRPVTSEPT 1224
Cdd:PRK10811   858 QREAEEVQVQPvvaEVPVAAAVEPVVSAPVVEAVAEVVEEPVVVAEPQPEEVVVVETTHPEVIA-APVTEQPQVITESDV 936
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1225 SQATrgrknrSSVKTPEPVVPTAPE---LQPSTSTDQPVTSEPTYQAtrgrknrssvktpEPVVPTAPELRPSTSTDRPV 1301
Cdd:PRK10811   937 AVAQ------EVAEHAEPVVEPQDEtadIEEAAETAEVVVAEPEVVA-------------QPAAPVVAEVAAEVETVTAV 997
                          490       500       510
                   ....*....|....*....|....*....|...
gi 2462492653 1302 TPKPTSRTTRSRTNMSSVKT-PETVVPtAPELQ 1333
Cdd:PRK10811   998 EPEVAPAQVPEATVEHNHATaPMTRAP-APEYV 1029
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
1141-1714 2.83e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 42.83  E-value: 2.83e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1141 PTSQATRS--RTNRSSVKTPEPVVPTAPELQPSTSTDQPVTSEPTSQVTRGRKSRSSVKTPETVVPTALELQPSTSTDRP 1218
Cdd:pfam03154   34 PTNEDLRSsgRNSPSAASTSSNDSKAESMKKSSKKIKEEAPSPLKSAKRQREKGASDTEEPERATAKKSKTQEISRPNSP 113
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1219 VTSEPTSQATRGRKNRSSvKTPEPVVPTAPELQPSTST--DQPVTSEPTYQATRGRKNRSSVKTPEPVVPTAPELRPSTS 1296
Cdd:pfam03154  114 SEGEGESSDGRSVNDEGS-SDPKDIDQDNRSTSPSIPSpqDNESDSDSSAQQQILQTQPPVLQAQSGAASPPSPPPPGTT 192
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1297 TDRPVTPKPTSRTTRSRTNMSSVKTPETVVPTAPELQISTSTDQPVTPKPTSrttrsrtnmssvknPESTVPIAPELPPS 1376
Cdd:pfam03154  193 QAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTLIQQTPTLHPQRLPS--------------PHPPLQPMTQPPPP 258
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1377 TSTEQPVTPEPTSRATRGRKNRSSGKTPETL---VPTAPKLEPSTSTDQPVTPEPTSQATRGRTNRSSVKTPEtvvPTAP 1453
Cdd:pfam03154  259 SQVSPQPLPQPSLHGQMPPMPHSLQTGPSHMqhpVPPQPFPLTPQSSQSQVPPGPSPAAPGQSQQRIHTPPSQ---SQLQ 335
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1454 ELQPstSTDQPVTPEPTSQatrgrtdrssvktpetvvptaPELQASASTDQPVTSEPTSRTTRGRKNRSSVKTPETVVPA 1533
Cdd:pfam03154  336 SQQP--PREQPLPPAPLSM---------------------PHIKPPPTTPIPQLPNPQSHKHPPHLSGPSPFQMNSNLPP 392
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1534 APELQP--STSTDQPVTPEPtsratrgrtnrssvkTPESIVPIAPELQPSTSRNQLVTPEPTSRATRCRTNRSSVKTPEP 1611
Cdd:pfam03154  393 PPALKPlsSLSTHHPPSAHP---------------PPLQLMPQSQQLPPPPAQPPVLTQSQSLPPPAASHPPTSGLHQVP 457
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1612 VVPTAPEPHPTTSTDQPVTPKLTsratrrktnrssvkTPKPVEPAASDLEPftPTDQSVTPEAIAQGGQSKTLRSSTVRA 1691
Cdd:pfam03154  458 SQSPFPQHPFVPGGPPPITPPSG--------------PPTSTSSAMPGIQP--PSSASVSSSGPVPAAVSCPLPPVQIKE 521
                          570       580
                   ....*....|....*....|...
gi 2462492653 1692 MPVPTTPEFQSPVTTDQPISPEP 1714
Cdd:pfam03154  522 EALDEAEEPESPPPPPRSPSPEP 544
Chi1 COG3469
Chitinase [Carbohydrate transport and metabolism];
1120-1349 3.03e-03

Chitinase [Carbohydrate transport and metabolism];


Pssm-ID: 442692 [Multi-domain]  Cd Length: 534  Bit Score: 42.43  E-value: 3.03e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1120 ATSAAPEPHPSTSTAQPVTPKPTSQATRSRTNRSSVKTPEPVVPTAPELQPSTSTDQPVTSEPTSQVTRGRKSRSSVKTP 1199
Cdd:COG3469      1 SSSVSTAASPTAGGASATAVTLLGAAATAASVTLTAATATTVVSTTGSVVVAASGSAGSGTGTTAASSTAATSSTTSTTA 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1200 ETVVPTALELQPSTSTDRPVTSEPTSQATRGRKNRSSVKTPEPVVPTAPELQPSTSTDQPVTSEPTYQATRGRKNrSSVK 1279
Cdd:COG3469     81 TATAAAAAATSTSATLVATSTASGANTGTSTVTTTSTGAGSVTSTTSSTAGSTTTSGASATSSAGSTTTTTTVSG-TETA 159
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1280 TPEPVVPTAPELRPSTSTDRPVTPKPTsrttrsrtnmssvkTPETVVPTAPELQISTSTDQPVTPKPTSR 1349
Cdd:COG3469    160 TGGTTTTSTTTTTTSASTTPSATTTAT--------------ATTASGATTPSATTTATTTGPPTPGLPKH 215
FHA_ZEP-like cd22702
forkhead associated (FHA) domain found in chloroplastic zeaxanthin epoxidase (ZEP) and similar ...
48-123 3.27e-03

forkhead associated (FHA) domain found in chloroplastic zeaxanthin epoxidase (ZEP) and similar proteins; ZEP, also called protein ABA DEFICIENT 1, ABA1, protein IMPAIRED IN BABA-INDUCED STERILITY 3, protein LOW EXPRESSION OF OSMOTIC STRESS-RESPONSIVE GENES 6, or protein NON-PHOTOCHEMICAL QUENCHING 2, plays an important role in the xanthophyll cycle and abscisic acid (ABA) biosynthesis. It converts zeaxanthin into antheraxanthin and subsequently violaxanthin. ZEP is required for resistance to osmotic and drought stresses, ABA-dependent stomatal closure, seed development and dormancy, modulation of defense gene expression, and disease resistance and non-photochemical quencing (NPQ). The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438754 [Multi-domain]  Cd Length: 123  Bit Score: 39.72  E-value: 3.27e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653   48 PLHLGKN-----VVGRMPDC-----SVALPFPSISKQHAEIEILawDKAPILRDCGSLNGTQILRPP---KVLSPGVSHR 114
Cdd:cd22702     23 PIRLTRDekqpcIIGSDPHQaisgiSVVIPSPQVSELHARITCK--NGAFFLTDLGSEHGTWINDNEgrrYRAPPNFPVR 100

                   ....*....
gi 2462492653  115 LRDQELILF 123
Cdd:cd22702    101 LHPSDVIEF 109
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
822-962 3.46e-03

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 42.75  E-value: 3.46e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653  822 ERVGPERGPLERETEKL-----LPERQTDVTGEEELTKGKQDREQKQLLARDTQRQE----------SDKNGESASPERD 886
Cdd:TIGR02169  194 DEKRQQLERLRREREKAeryqaLLKEKREYEGYELLKEKEALERQKEAIERQLASLEeeleklteeiSELEKRLEEIEQL 273
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462492653  887 RESLKVEIETSEEIQEKQVQKQTLPSKAFEREVERPVANRECDPAELEEKVPKVILERDTQRGEPEGGSQDQKGQA 962
Cdd:TIGR02169  274 LEELNKKIKDLGEEEQLRVKEKIGELEAEIASLERSIAEKERELEDAEERLAKLEAEIDKLLAEIEELEREIEEER 349
PLN03209 PLN03209
translocon at the inner envelope of chloroplast subunit 62; Provisional
1316-1583 3.80e-03

translocon at the inner envelope of chloroplast subunit 62; Provisional


Pssm-ID: 178748 [Multi-domain]  Cd Length: 576  Bit Score: 42.22  E-value: 3.80e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1316 MSSVKTPETVVPTAPELqisTSTDQPVTPKPTSRTTRSRTNMSSVKNPESTVPIAPELPPSTSTEQPvtpePTSRATRGR 1395
Cdd:PLN03209   297 LSYCKVVEVIAETTAPL---TPMEELLAKIPSQRVPPKESDAADGPKPVPTKPVTPEAPSPPIEEEP----PQPKAVVPR 369
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1396 KNRSSGKTPETLVPTAPKLEPSTSTDQPVTPEPTSQATRGRTNRSSVKTPETVVPTAPeLQPSTSTDQPVTP-------- 1467
Cdd:PLN03209   370 PLSPYTAYEDLKPPTSPIPTPPSSSPASSKSVDAVAKPAEPDVVPSPGSASNVPEVEP-AQVEAKKTRPLSPyaryedlk 448
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1468 EPTSQATRGRTDRSSVKTPETVVPTAPELQ-ASASTDQPVTSEPTSRTTRGRKNRSSVKTPETVVPAAPELQPSTSTDQP 1546
Cdd:PLN03209   449 PPTSPSPTAPTGVSPSVSSTSSVPAVPDTApATAATDAAAPPPANMRPLSPYAVYDDLKPPTSPSPAAPVGKVAPSSTNE 528
                          250       260       270       280
                   ....*....|....*....|....*....|....*....|.
gi 2462492653 1547 VTP----EPTSRATRGRTNRSSVKTPESIVPIAPELQPSTS 1583
Cdd:PLN03209   529 VVKvgnsAPPTALADEQHHAQPKPRPLSPYTMYEDLKPPTS 569
PHA03255 PHA03255
BDLF3; Provisional
1280-1465 3.97e-03

BDLF3; Provisional


Pssm-ID: 165513 [Multi-domain]  Cd Length: 234  Bit Score: 41.04  E-value: 3.97e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1280 TPEPVVPTAPELRPSTSTDRPVTPKPTSRTTRSRTNMSSVKTPETVVPTAPELQISTSTDQPVTPKPTSRTTRSRTNMSS 1359
Cdd:PHA03255    28 GSSTASAGNVTGTTAVTTPSPSASGPSTNQSTTLTTTSAPITTTAILSTNTTTVTSTGTTVTPVPTTSNASTINVTTKVT 107
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1360 VKNPESTvpiapelPPSTSTEQPVTPEPTSRATrgrknrsSGKTPETLVPTAPKLepststdqpvTPEPTSQAtrgrTNR 1439
Cdd:PHA03255   108 AQNITAT-------EAGTGTSTGVTSNVTTRSS-------STTSATTRITNATTL----------APTLSSKG----TSN 159
                          170       180
                   ....*....|....*....|....*..
gi 2462492653 1440 SSVKTPEtvVPTAP-ELQPSTSTDQPV 1465
Cdd:PHA03255   160 ATKTTAE--LPTVPdERQPSLSYGLPL 184
PHA03255 PHA03255
BDLF3; Provisional
1391-1547 5.15e-03

BDLF3; Provisional


Pssm-ID: 165513 [Multi-domain]  Cd Length: 234  Bit Score: 40.66  E-value: 5.15e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1391 ATRGRKNRSSGKTPETLVPTAPKLEPSTSTDQPVTPEPTSQATRGRTNRSSVKTPETVVPTAPelqpstSTDQPVTPEPT 1470
Cdd:PHA03255    30 STASAGNVTGTTAVTTPSPSASGPSTNQSTTLTTTSAPITTTAILSTNTTTVTSTGTTVTPVP------TTSNASTINVT 103
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1471 SQATRgrtdrSSVKTPETVVPTAPELQASASTDqpvTSEPTSRTTRGRKNRSSVKTPETV-----------VPAAP-ELQ 1538
Cdd:PHA03255   104 TKVTA-----QNITATEAGTGTSTGVTSNVTTR---SSSTTSATTRITNATTLAPTLSSKgtsnatkttaeLPTVPdERQ 175

                   ....*....
gi 2462492653 1539 PSTSTDQPV 1547
Cdd:PHA03255   176 PSLSYGLPL 184
FHA_RAD53-like_rpt2 cd22690
second forkhead associated (FHA) domain found in Saccharomyces cerevisiae Serine ...
32-127 5.97e-03

second forkhead associated (FHA) domain found in Saccharomyces cerevisiae Serine/threonine-protein kinase RAD53 and similar proteins; RAD53, also called CHEK2 homolog, or serine-protein kinase 1 (Spk1), is a nuclear protein kinase that phosphorylates proteins on serine, threonine, and tyrosine. It controls S-phase checkpoint as well as G1 and G2 DNA damage checkpoints and prevents entry into anaphase and mitotic exit after DNA damage via regulation of the Polo kinase CDC5. It may be involved in the phosphorylation of RPH1. RAD53 contains two FHA domains. This model corresponds to the second one. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438742 [Multi-domain]  Cd Length: 105  Bit Score: 38.43  E-value: 5.97e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653   32 GRLHIFSGAHgpeKDFPLHLGKNVVGRMPDCSVALPFPSISKQHAEIEILAWDKAPI---LRDCgSLNGTQILRppKVLS 108
Cdd:cd22690      2 GRLKSLNPSY---PDIELTQNTTFIGRSKDCDEEITDPRISKHHCIITRKRSGKGLDdvyVTDT-STNGTFINN--NRLG 75
                           90       100
                   ....*....|....*....|
gi 2462492653  109 PGVSHRLRD-QELILFADLL 127
Cdd:cd22690     76 KGSQSLLQDgDEIVLIWDKN 95
PHA03369 PHA03369
capsid maturational protease; Provisional
1434-1718 6.32e-03

capsid maturational protease; Provisional


Pssm-ID: 223061 [Multi-domain]  Cd Length: 663  Bit Score: 41.52  E-value: 6.32e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1434 RGRTNRSSVKTPETVVPTAPeLQPSTSTDQPVTPEPTSQAT---RGRTDRSSVKTPETVVPTAPELQASASTDQPVTSEP 1510
Cdd:PHA03369   340 GLKAHNEILKTASLTAPSRV-LAAAAKVAVIAAPQTHTGPAdrqRPQRPDGIPYSVPARSPMTAYPPVPQFCGDPGLVSP 418
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1511 TSRTTRGRKNRSSVKTPETVVPAAPELQPSTSTDQPVTPEPTSRAT-RGRTNRSSVKtpESIVPIAPELQPSTSRNQLVT 1589
Cdd:PHA03369   419 YNPQSPGTSYGPEPVGPVPPQPTNPYVMPISMANMVYPGHPQEHGHeRKRKRGGELK--EELIETLKLVKKLKEEQESLA 496
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1590 PEPTSRATRCRTNRSS--------VKTPEPVV---PTAPEPHPTTSTDQPVTPKLTSRATRRKTNRSSVKTPKPVEPAAS 1658
Cdd:PHA03369   497 KELEATAHKSEIKKIAesefknagAKTAAANIepnCSADAAAPATKRARPETKTELEAVVRFPYQIRNMESPAFVHSFTS 576
                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462492653 1659 DLEPFTPTDQSVTPEAIAqgGQSKTLrSSTVRAMPVPTTPEFQ-------SPVTTDQPISPEPITQP 1718
Cdd:PHA03369   577 TTLAAAAGQGSDTAEALA--GAIETL-LTQASAQPAGLSLPAPavpvnasTPASTPPPLAPQEPPQP 640
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
1096-1268 6.77e-03

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 41.48  E-value: 6.77e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1096 SELEPFHPKPKIRTRKSSRMTPFPATSAAPEPHPSTSTAQPVTPKPTSQATRSRTNRSSVKTPEPVVPTAPELQPSTSTD 1175
Cdd:pfam17823  294 NPAAPMGAQAQGPIIQVSTDQPVHNTAGEPTPSPSNTTLEPNTPKSVASTNLAVVTTTKAQAKEPSASPVPVLHTSMIPE 373
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1176 QPVTSePTSQvtrgrksrssvktPETVVPTALELQPST--STDRPVTSEPTSQATRGRKNRSSvktPEPVVPTAPELQPS 1253
Cdd:pfam17823  374 VEATS-PTTQ-------------PSPLLPTQGAAGPGIllAPEQVATEATAGTASAGPTPRSS---GDPKTLAMASCQLS 436
                          170
                   ....*....|....*.
gi 2462492653 1254 TSTDQ-PVTSEPTYQA 1268
Cdd:pfam17823  437 TQGQYlVVTTDPLTPA 452
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
1428-1667 7.57e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 41.37  E-value: 7.57e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1428 PTSQATRGRTNRSSVKTPETVVPTAPELQPSTSTDQPVTPEPTSQATRGRTDRSSVKTPETVVPTAPELQASASTDQPVT 1507
Cdd:PRK07003   381 PAPGARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAPPAAPAPPATADRGDDAADGDAPVPAKANARASAD 460
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1508 SEPTSRTTRGRKNRSSVKTPETVVPAAPELQPSTSTDQPvtPEPTSRATRGRTNRSSVKTPESIVPIAPElQPSTSRNQL 1587
Cdd:PRK07003   461 SRCDERDAQPPADSGSASAPASDAPPDAAFEPAPRAAAP--SAATPAAVPDARAPAAASREDAPAAAAPP-APEARPPTP 537
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1588 VTPEPTSRAT--------------RCRTNRSSVKTPEPVVPTAPEPHPTTSTDQPVTPKLTSRATRRKTNRSSVKTpKPV 1653
Cdd:PRK07003   538 AAAAPAARAGgaaaaldvlrnagmRVSSDRGARAAAAAKPAAAPAAAPKPAAPRVAVQVPTPRARAATGDAPPNGA-ARA 616
                          250
                   ....*....|....
gi 2462492653 1654 EPAASDLEPFTPTD 1667
Cdd:PRK07003   617 EQAAESRGAPPPWE 630
FHA_Rv1747-like_rpt2 cd22737
second forkhead associated (FHA) domain found in Mycobacterium tuberculosis ABC transporter ...
56-98 7.76e-03

second forkhead associated (FHA) domain found in Mycobacterium tuberculosis ABC transporter ATP-binding/permease protein Rv1747 and similar proteins; Rv1747 is a putative ATP-binding cassette (ABC) transporter involved in the translocation of an unknown substrate across the membrane. It is required for normal virulent infection by M. tuberculosis. Rv1747 has a cytoplasmic regulatory module consisting of two pThr-interacting forkhead-associated (FHA) domains connected by a conformationally disordered linker with two phospho-acceptor threonines (pThr). Recruitment and phosphorylation of Rv1747 depend on the interaction between its two non-redundant FHA domains and the autophosphorylated form of serine/threonine protein kinase PknF. This model corresponds to the second FHA domain, which has a circularly permuted FHA domain fold with a conserved pThr-binding interface.


Pssm-ID: 439356 [Multi-domain]  Cd Length: 93  Bit Score: 37.86  E-value: 7.76e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 2462492653   56 VGRMPDCSVALPFPSISKQHAEIEILawDKAPILRDCGSLNGT 98
Cdd:cd22737     25 IGRASDNDIVIPEGSVSRHHATLVPT--PGGTQIRDLRSTNGT 65
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
1538-1880 7.99e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 41.31  E-value: 7.99e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1538 QPSTSTDQPVTPEPTSRATRGRTNRSSVKTPESIVPIAPELQPSTSRNQLVTPEPTSRATRCRTNRSSVKTPEPvvptAP 1617
Cdd:PHA03307    40 QGQLVSDSAELAAVTVVAGAAACDRFEPPTGPPPGPGTEAPANESRSTPTWSLSTLAPASPAREGSPTPPGPSS----PD 115
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1618 EPHPTTSTDQPVTPKLTSRATRRKTNRSSVKTPKPVEPAASDLEPFTPTDQSVTPEAiaqggqsktlrsSTVRAMPVPTT 1697
Cdd:PHA03307   116 PPPPTPPPASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQA------------ALPLSSPEETA 183
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1698 PEFQSPVTTDQPISPEPITQPSCIKRQRAAGNPGSLAAPIDHKPCSAPLEPK-SQASRNQRWGAVRAAESLTAIPEPaSP 1776
Cdd:PHA03307   184 RAPSSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASsSDSSSSESSGCGWGPENECPLPRP-AP 262
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1777 QLLETPIHASQIQKVE-----PAGRSRFTPELQPKASQSRKRSLATMDSPPHQKQ--PQRGEVSQKTVIIKEEEEDTAEK 1849
Cdd:PHA03307   263 ITLPTRIWEASGWNGPssrpgPASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSssSSRESSSSSTSSSSESSRGAAVS 342
                          330       340       350
                   ....*....|....*....|....*....|.
gi 2462492653 1850 PGKEEDvvtpKPGKRKRDQAEEEPNRIPSRS 1880
Cdd:PHA03307   343 PGPSPS----RSPSPSRPPPPADPSSPRKRP 369
Pneumo_att_G pfam05539
Pneumovirinae attachment membrane glycoprotein G;
1222-1377 8.33e-03

Pneumovirinae attachment membrane glycoprotein G;


Pssm-ID: 114270 [Multi-domain]  Cd Length: 408  Bit Score: 40.80  E-value: 8.33e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1222 EPTSQATRGRKNRSSVKTPEPVVPT--APELQPSTSTDQPVTSEPTYQAT--RGRKNRSSVKTPEPVVPTAPELRPSTST 1297
Cdd:pfam05539  167 EPKTAVTTSKTTSWPTEVSHPTYPSqvTPQSQPATQGHQTATANQRLSSTepVGTQGTTTSSNPEPQTEPPPSQRGPSGS 246
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1298 DR--PVTPKPTSRTTRSrtnmSSVKTPETVVPTAPELQ---ISTSTDQPVTPKPTSR--TTRSRTNMSSVKNPESTVPIA 1370
Cdd:pfam05539  247 PQhpPSTTSQDQSTTGD----GQEHTQRRKTPPATSNRrspHSTATPPPTTKRQETGrpTPRPTATTQSGSSPPHSSPPG 322

                   ....*..
gi 2462492653 1371 PELPPST 1377
Cdd:pfam05539  323 VQANPTT 329
PLN03209 PLN03209
translocon at the inner envelope of chloroplast subunit 62; Provisional
1369-1611 9.37e-03

translocon at the inner envelope of chloroplast subunit 62; Provisional


Pssm-ID: 178748 [Multi-domain]  Cd Length: 576  Bit Score: 41.07  E-value: 9.37e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1369 IAPELPPSTSTEQPVTPEPTSRATRgrKNRSSGKTPETLVPTAPKLEPSTSTDQPVTPEPTSQATRG---RTNRSSVKTP 1445
Cdd:PLN03209   306 IAETTAPLTPMEELLAKIPSQRVPP--KESDAADGPKPVPTKPVTPEAPSPPIEEEPPQPKAVVPRPlspYTAYEDLKPP 383
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1446 ETVVPTAPELQPSTSTDQPVTPEPTSQATRGRTDRSSvKTPETVVPTAPELQA---SASTDQPVTSEPTSRTTRGRKNRS 1522
Cdd:PLN03209   384 TSPIPTPPSSSPASSKSVDAVAKPAEPDVVPSPGSAS-NVPEVEPAQVEAKKTrplSPYARYEDLKPPTSPSPTAPTGVS 462
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1523 SVKTPETVVPAAPELQPSTS-TDQPVTPEPTSRATRGRTNRSSVKTPESIVPIAPELQPSTSRNQLVTPEPTSRATRCRT 1601
Cdd:PLN03209   463 PSVSSTSSVPAVPDTAPATAaTDAAAPPPANMRPLSPYAVYDDLKPPTSPSPAAPVGKVAPSSTNEVVKVGNSAPPTALA 542
                          250
                   ....*....|
gi 2462492653 1602 NRSSVKTPEP 1611
Cdd:PLN03209   543 DEQHHAQPKP 552
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
1042-1350 9.53e-03

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 40.71  E-value: 9.53e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1042 VPEAPA--PPQKPLNSQSQKHLAPPPLLSPLLPsikpTVRKTRQDGSQEAPEAPLSSELEPFHPKPKIRTRKSSRMTPFP 1119
Cdd:pfam17823  149 ACRANAsaAPRAAIAAASAPHAASPAPRTAASS----TTAASSTTAASSAPTTAASSAPATLTPARGISTAATATGHPAA 224
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1120 ATSAAPEPHPSTSTAQPVTPKPTSQATRSRTNRSSVKTPEPVVPTAPELQPSTSTDQPVTSEPTSQVTRG---------R 1190
Cdd:pfam17823  225 GTALAAVGNSSPAAGTVTAAVGTVTPAALATLAAAAGTVASAAGTINMGDPHARRLSPAKHMPSDTMARNpaapmgaqaQ 304
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1191 KSRSSVKTPETVVPTALELQPSTSTDRPVTSEPTSQA--------TRGRKNRSSVKTPEPVVPTA--PELQPSTSTDQPV 1260
Cdd:pfam17823  305 GPIIQVSTDQPVHNTAGEPTPSPSNTTLEPNTPKSVAstnlavvtTTKAQAKEPSASPVPVLHTSmiPEVEATSPTTQPS 384
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1261 TSEPTyQATRGrknrssvktpePVVPTAPELRPSTSTDRPVTPKPTSRTTrsrtnmSSVKTPETV-VPTAPELQISTSTD 1339
Cdd:pfam17823  385 PLLPT-QGAAG-----------PGILLAPEQVATEATAGTASAGPTPRSS------GDPKTLAMAsCQLSTQGQYLVVTT 446
                          330
                   ....*....|.
gi 2462492653 1340 QPVTPKPTSRT 1350
Cdd:pfam17823  447 DPLTPALVDKM 457
Pneumo_att_G pfam05539
Pneumovirinae attachment membrane glycoprotein G;
1304-1466 9.64e-03

Pneumovirinae attachment membrane glycoprotein G;


Pssm-ID: 114270 [Multi-domain]  Cd Length: 408  Bit Score: 40.80  E-value: 9.64e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1304 KPTSRTTRSRTNMSSVKTPETVVPT--APELQISTSTDQPVTPKPTSRTT----RSRTNMSSVKNPESTVPIAPELPPST 1377
Cdd:pfam05539  167 EPKTAVTTSKTTSWPTEVSHPTYPSqvTPQSQPATQGHQTATANQRLSSTepvgTQGTTTSSNPEPQTEPPPSQRGPSGS 246
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492653 1378 STEQPVTPEPTSrATRGRKNRSsgkTPETLVPTAPklEPSTSTDQPVTPEPTSQATRGRTNRSSVKTPETVVPTAPELQP 1457
Cdd:pfam05539  247 PQHPPSTTSQDQ-STTGDGQEH---TQRRKTPPAT--SNRRSPHSTATPPPTTKRQETGRPTPRPTATTQSGSSPPHSSP 320

                   ....*....
gi 2462492653 1458 STSTDQPVT 1466
Cdd:pfam05539  321 PGVQANPTT 329
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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