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Conserved domains on  [gi|2462492160|ref|XP_054185932|]
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transcription factor TFIIIB component B'' homolog isoform X2 [Homo sapiens]

Protein Classification

HYOU1-like protein; Homer/Vesl family protein( domain architecture ID 13870179)

HYOU1 (hypoxia up-regulated protein 1)-like protein| Homer/Vesl family protein is a synaptic scaffolding protein, required for long-term potentiation, a form of synaptic plasticity thought to underlie memory formation

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
Myb_DNA-bind_7 pfam15963
Myb DNA-binding like;
293-377 9.98e-36

Myb DNA-binding like;


:

Pssm-ID: 464956 [Multi-domain]  Cd Length: 85  Bit Score: 131.12  E-value: 9.98e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492160  293 SFRKNYYSKPWSNKETDMFFLAISMVGTDFSMIGQLFPHRARIEIKNKFKREEKTNGWRIDKAFQEKRPFDFDFFAHLLQ 372
Cdd:pfam15963    1 SFRKRKKTKRWSKEETELFYKALSMFGTDFSLIAQLFPGRTRRQIKLKFKREERKNPELVDKALKNRKPFDLEEFKRLLE 80


                   ....*
gi 2462492160  373 KVLAE 377
Cdd:pfam15963   81 KEKEE 85
PRK02224 super family cl32023
DNA double-strand break repair Rad50 ATPase;
824-1336 5.99e-03

DNA double-strand break repair Rad50 ATPase;


The actual alignment was detected with superfamily member PRK02224:

Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 41.95  E-value: 5.99e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492160  824 RREISSKEEVLEKILVSGEMAAALRETVRLDTSPKEMVPAEINT-KEMQSDLKETGRRAISPREKILDVIDD----TIEM 898
Cdd:PRK02224   212 ESELAELDEEIERYEEQREQARETRDEADEVLEEHEERREELETlEAEIEDLRETIAETEREREELAEEVRDlrerLEEL 291

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492160  899 ETGLKAMGREICLREKTPEVI-DATEEIDKDLEEAgRREISPQKNGPEEVKplGEVETdlkATGNESSPREKTPEVTDAT 977
Cdd:PRK02224   292 EEERDDLLAEAGLDDADAEAVeARREELEDRDEEL-RDRLEECRVAAQAHN--EEAES---LREDADDLEERAEELREEA 365

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492160  978 EEIDKNLEETgRRKISPRENGPEEVKpvDEMETDLNATGressprektpeviDATEEIDLEETEREvSPQENGLEEVKPL 1057
Cdd:PRK02224   366 AELESELEEA-REAVEDRREEIEELE--EEIEELRERFG-------------DAPVDLGNAEDFLE-ELREERDELRERE 428

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492160 1058 GEMETDLK------ATGRDSFPRGKTPE---------VIDAIEEIEIDLEETEREISPQENGLEEVKPLGEMQTDLKATG 1122
Cdd:PRK02224   429 AELEATLRtarervEEAEALLEAGKCPEcgqpvegspHVETIEEDRERVEELEAELEDLEEEVEEVEERLERAEDLVEAE 508

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492160 1123 REISPREKTPEviDATEEIDKDLEETGRREISPEEngpeevkpVDEMETDLKTTGREgsSREKTREVIDAAEVIETDLEE 1202
Cdd:PRK02224   509 DRIERLEERRE--DLEELIAERRETIEEKRERAEE--------LRERAAELEAEAEE--KREAAAEAEEEAEEAREEVAE 576

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492160 1203 TEREISPQENGPEEVKPVGKMETDLKEIREEISQREKVLAEFSAIREKEID-LKETGKRDIPIMEKVSGkmAVVEEMEAD 1281
Cdd:PRK02224   577 LNSKLAELKERIESLERIRTLLAAIADAEDEIERLREKREALAELNDERRErLAEKRERKRELEAEFDE--ARIEEARED 654

                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2462492160 1282 LKETgkENFRERGSEEICVTEEKVAELkqtgKTDISPRENELEETSTSRQTDTHL 1336
Cdd:PRK02224   655 KERA--EEYLEQVEEKLDELREERDDL----QAEIGAVENELEELEELRERREAL 703
 
Name Accession Description Interval E-value
Myb_DNA-bind_7 pfam15963
Myb DNA-binding like;
293-377 9.98e-36

Myb DNA-binding like;


Pssm-ID: 464956 [Multi-domain]  Cd Length: 85  Bit Score: 131.12  E-value: 9.98e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492160  293 SFRKNYYSKPWSNKETDMFFLAISMVGTDFSMIGQLFPHRARIEIKNKFKREEKTNGWRIDKAFQEKRPFDFDFFAHLLQ 372
Cdd:pfam15963    1 SFRKRKKTKRWSKEETELFYKALSMFGTDFSLIAQLFPGRTRRQIKLKFKREERKNPELVDKALKNRKPFDLEEFKRLLE 80


                   ....*
gi 2462492160  373 KVLAE 377
Cdd:pfam15963   81 KEKEE 85
BDP1 COG5118
Transcription initiation factor TFIIIB, Bdp1 subunit [Transcription];
254-388 2.52e-17

Transcription initiation factor TFIIIB, Bdp1 subunit [Transcription];


Pssm-ID: 227448 [Multi-domain]  Cd Length: 507  Bit Score: 87.85  E-value: 2.52e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492160  254 GSIILDEESLTVEVLRTKGPCVVE----ENDPIFERgstTTYSSFRKNYYSKPWSNKETDMFFLAISMVGTDFSMIGQLF 329
Cdd:COG5118    318 GHIVVDEANMYVDRHKNASIEVEEmevvEENPFARI---VTSSTFGKKKGALRWSKKEIEKFYKALSIWGTDFSLISSLF 394

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462492160  330 PHRARIEIKNKFKREEKTNGWRIDKAFQEKRPFDFDFFAHLLQKV---LAEEEKRKQKSVKN 388
Cdd:COG5118    395 PNRERKQIKAKFIKEEKVNPERINEALNEKKPFDQVEYNKLRSYLlekLIELQNEHKHHMKE 456
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
824-1336 5.99e-03

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 41.95  E-value: 5.99e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492160  824 RREISSKEEVLEKILVSGEMAAALRETVRLDTSPKEMVPAEINT-KEMQSDLKETGRRAISPREKILDVIDD----TIEM 898
Cdd:PRK02224   212 ESELAELDEEIERYEEQREQARETRDEADEVLEEHEERREELETlEAEIEDLRETIAETEREREELAEEVRDlrerLEEL 291

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492160  899 ETGLKAMGREICLREKTPEVI-DATEEIDKDLEEAgRREISPQKNGPEEVKplGEVETdlkATGNESSPREKTPEVTDAT 977
Cdd:PRK02224   292 EEERDDLLAEAGLDDADAEAVeARREELEDRDEEL-RDRLEECRVAAQAHN--EEAES---LREDADDLEERAEELREEA 365

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492160  978 EEIDKNLEETgRRKISPRENGPEEVKpvDEMETDLNATGressprektpeviDATEEIDLEETEREvSPQENGLEEVKPL 1057
Cdd:PRK02224   366 AELESELEEA-REAVEDRREEIEELE--EEIEELRERFG-------------DAPVDLGNAEDFLE-ELREERDELRERE 428

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492160 1058 GEMETDLK------ATGRDSFPRGKTPE---------VIDAIEEIEIDLEETEREISPQENGLEEVKPLGEMQTDLKATG 1122
Cdd:PRK02224   429 AELEATLRtarervEEAEALLEAGKCPEcgqpvegspHVETIEEDRERVEELEAELEDLEEEVEEVEERLERAEDLVEAE 508

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492160 1123 REISPREKTPEviDATEEIDKDLEETGRREISPEEngpeevkpVDEMETDLKTTGREgsSREKTREVIDAAEVIETDLEE 1202
Cdd:PRK02224   509 DRIERLEERRE--DLEELIAERRETIEEKRERAEE--------LRERAAELEAEAEE--KREAAAEAEEEAEEAREEVAE 576

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492160 1203 TEREISPQENGPEEVKPVGKMETDLKEIREEISQREKVLAEFSAIREKEID-LKETGKRDIPIMEKVSGkmAVVEEMEAD 1281
Cdd:PRK02224   577 LNSKLAELKERIESLERIRTLLAAIADAEDEIERLREKREALAELNDERRErLAEKRERKRELEAEFDE--ARIEEARED 654

                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2462492160 1282 LKETgkENFRERGSEEICVTEEKVAELkqtgKTDISPRENELEETSTSRQTDTHL 1336
Cdd:PRK02224   655 KERA--EEYLEQVEEKLDELREERDDL----QAEIGAVENELEELEELRERREAL 703
 
Name Accession Description Interval E-value
Myb_DNA-bind_7 pfam15963
Myb DNA-binding like;
293-377 9.98e-36

Myb DNA-binding like;


Pssm-ID: 464956 [Multi-domain]  Cd Length: 85  Bit Score: 131.12  E-value: 9.98e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492160  293 SFRKNYYSKPWSNKETDMFFLAISMVGTDFSMIGQLFPHRARIEIKNKFKREEKTNGWRIDKAFQEKRPFDFDFFAHLLQ 372
Cdd:pfam15963    1 SFRKRKKTKRWSKEETELFYKALSMFGTDFSLIAQLFPGRTRRQIKLKFKREERKNPELVDKALKNRKPFDLEEFKRLLE 80


                   ....*
gi 2462492160  373 KVLAE 377
Cdd:pfam15963   81 KEKEE 85
BDP1 COG5118
Transcription initiation factor TFIIIB, Bdp1 subunit [Transcription];
254-388 2.52e-17

Transcription initiation factor TFIIIB, Bdp1 subunit [Transcription];


Pssm-ID: 227448 [Multi-domain]  Cd Length: 507  Bit Score: 87.85  E-value: 2.52e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492160  254 GSIILDEESLTVEVLRTKGPCVVE----ENDPIFERgstTTYSSFRKNYYSKPWSNKETDMFFLAISMVGTDFSMIGQLF 329
Cdd:COG5118    318 GHIVVDEANMYVDRHKNASIEVEEmevvEENPFARI---VTSSTFGKKKGALRWSKKEIEKFYKALSIWGTDFSLISSLF 394

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462492160  330 PHRARIEIKNKFKREEKTNGWRIDKAFQEKRPFDFDFFAHLLQKV---LAEEEKRKQKSVKN 388
Cdd:COG5118    395 PNRERKQIKAKFIKEEKVNPERINEALNEKKPFDQVEYNKLRSYLlekLIELQNEHKHHMKE 456
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
824-1336 5.99e-03

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 41.95  E-value: 5.99e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492160  824 RREISSKEEVLEKILVSGEMAAALRETVRLDTSPKEMVPAEINT-KEMQSDLKETGRRAISPREKILDVIDD----TIEM 898
Cdd:PRK02224   212 ESELAELDEEIERYEEQREQARETRDEADEVLEEHEERREELETlEAEIEDLRETIAETEREREELAEEVRDlrerLEEL 291

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492160  899 ETGLKAMGREICLREKTPEVI-DATEEIDKDLEEAgRREISPQKNGPEEVKplGEVETdlkATGNESSPREKTPEVTDAT 977
Cdd:PRK02224   292 EEERDDLLAEAGLDDADAEAVeARREELEDRDEEL-RDRLEECRVAAQAHN--EEAES---LREDADDLEERAEELREEA 365

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492160  978 EEIDKNLEETgRRKISPRENGPEEVKpvDEMETDLNATGressprektpeviDATEEIDLEETEREvSPQENGLEEVKPL 1057
Cdd:PRK02224   366 AELESELEEA-REAVEDRREEIEELE--EEIEELRERFG-------------DAPVDLGNAEDFLE-ELREERDELRERE 428

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492160 1058 GEMETDLK------ATGRDSFPRGKTPE---------VIDAIEEIEIDLEETEREISPQENGLEEVKPLGEMQTDLKATG 1122
Cdd:PRK02224   429 AELEATLRtarervEEAEALLEAGKCPEcgqpvegspHVETIEEDRERVEELEAELEDLEEEVEEVEERLERAEDLVEAE 508

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492160 1123 REISPREKTPEviDATEEIDKDLEETGRREISPEEngpeevkpVDEMETDLKTTGREgsSREKTREVIDAAEVIETDLEE 1202
Cdd:PRK02224   509 DRIERLEERRE--DLEELIAERRETIEEKRERAEE--------LRERAAELEAEAEE--KREAAAEAEEEAEEAREEVAE 576

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492160 1203 TEREISPQENGPEEVKPVGKMETDLKEIREEISQREKVLAEFSAIREKEID-LKETGKRDIPIMEKVSGkmAVVEEMEAD 1281
Cdd:PRK02224   577 LNSKLAELKERIESLERIRTLLAAIADAEDEIERLREKREALAELNDERRErLAEKRERKRELEAEFDE--ARIEEARED 654

                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2462492160 1282 LKETgkENFRERGSEEICVTEEKVAELkqtgKTDISPRENELEETSTSRQTDTHL 1336
Cdd:PRK02224   655 KERA--EEYLEQVEEKLDELREERDDL----QAEIGAVENELEELEELRERREAL 703
PTZ00121 PTZ00121
MAEBL; Provisional
 913-1358 8.69e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 41.67  E-value: 8.69e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492160  913 EKTPEVIDATEEIDKDLEEAGRREISPQKngPEEVKPLGEVETDLKATGNESSPREKTPEVTDATEEIDKNLEEtgrRKI 992
Cdd:PTZ00121  1437 KKKAEEAKKADEAKKKAEEAKKAEEAKKK--AEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEA---KKK 1511

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492160  993 SPRENGPEEVKPVDEMETDLNAtgRESSPREKTPEVIDATEEIDLEETEREvspqenglEEVKplgEMETDLKATGRDSF 1072
Cdd:PTZ00121  1512 ADEAKKAEEAKKADEAKKAEEA--KKADEAKKAEEKKKADELKKAEELKKA--------EEKK---KAEEAKKAEEDKNM 1578

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492160 1073 PRGKTPEVIDAIEEIEIDLEETEREISPQEngLEEVKPLGEMQTDLKATGREISPREKTPEVIDATEEIDKDLEETGRRE 1152
Cdd:PTZ00121  1579 ALRKAEEAKKAEEARIEEVMKLYEEEKKMK--AEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAE 1656

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492160 1153 ISPEENGPEEVKPVDEMETDLKTTGREGSSREKTREVIDAAEVIETDLEETEREISPQENGPEEVKPVGKMETDLKEIRE 1232
Cdd:PTZ00121  1657 EENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKKAEELKKAEEENKIKAEEAK 1736

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462492160 1233 EISQREKVLAEFSAIREKEID-LKETGKRDIPIMEKVSGKMAVVEEMEADLKETGKENFRERGSEEICVTEEKVAELKQT 1311
Cdd:PTZ00121  1737 KEAEEDKKKAEEAKKDEEEKKkIAHLKKEEEKKAEEIRKEKEAVIEEELDEEDEKRRMEVDKKIKDIFDNFANIIEGGKE 1816

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|....*..
gi 2462492160 1312 GKTDISPREnELEETSTSRQTDTHLMQSGSNDFSAVPSLDIQNISSE 1358
Cdd:PTZ00121  1817 GNLVINDSK-EMEDSAIKEVADSKNMQLEEADAFEKHKFNKNNENGE 1862
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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