NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2462494865|ref|XP_054186995|]
View 

uncharacterized protein C6orf136 isoform X1 [Homo sapiens]

Protein Classification

nuclear transport factor 2 family protein( domain architecture ID 233)

nuclear transport factor 2 (NTF2) family protein, similar to Aspergillus flavus scytalone dehydratases, Pseudomonas putida benzene 1,2-dioxygenase subunit beta, and many other members with similar structural details but divergent functions

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
NTF2_like super family cl09109
Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 ...
 330-363 6.63e-11

Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of divergent evolution wherein the proteins have many common structural details but diverge greatly in their function. For example, nuclear transport factor 2 (NTF2) mediates the nuclear import of RanGDP and binds to both RanGDP and FxFG repeat-containing nucleoporins while Ketosteroid isomerases catalyze the isomerization of delta-5-3-ketosteroid to delta-4-3-ketosteroid, by intramolecular transfer of the C4-beta proton to the C6-beta position. While the function of the beta sub-unit of the Ring hydroxylating dioxygenases is not known, Scytalone Dehydratases catalyzes two reactions in the biosynthetic pathway that produces fungal melanin. Members of the NTF2-like superfamily are widely distributed among bacteria, archaea and eukaryotes.


The actual alignment was detected with superfamily member pfam10184:

Pssm-ID: 471850  Cd Length: 113  Bit Score: 58.81  E-value: 6.63e-11
                          10        20        30
                  ....*....|....*....|....*....|....
gi 2462494865 330 SVMYERLRQELPKLFLQSHDYSLYSLDVEFINEI 363
Cdd:pfam10184   1 ADVVEILREDLPRLFPKDQDYSIYSEDVYFIDPL 34
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 116-324 4.11e-03

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 39.54  E-value: 4.11e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462494865  116 PDSPRLPVPRGDLKGRGREIRSPAAAPSrssPAQTRPAGRPQqPARLALGERSWQEGRPV---CTRFGPLRPGWQDGHAP 192
Cdd:PHA03247  2619 PDTHAPDPPPPSPSPAANEPDPHPPPTV---PPPERPRDDPA-PGRVSRPRRARRLGRAAqasSPPQRPRRRAARPTVGS 2694

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462494865  193 SRDGASRTPSGTEDQLYP-GTLPFPPLWPHSTTTTSPSSPLFWSPLPPRLPTQRLPQVPPLPLPQIQALSSAWVVLPPGK 271
Cdd:PHA03247  2695 LTSLADPPPPPPTPEPAPhALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAA 2774

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 2462494865  272 GEEGPGPELHSGCLDGLRSLFEGPPCPYPGAWIPFQVPG-----TAHPSPATPSGDPS 324
Cdd:PHA03247  2775 PAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLApaaalPPAASPAGPLPPPT 2832
 
Name Accession Description Interval E-value
DUF2358 pfam10184
Uncharacterized conserved protein (DUF2358); DUF2358 is a family of conserved proteins found ...
 330-363 6.63e-11

Uncharacterized conserved protein (DUF2358); DUF2358 is a family of conserved proteins found from plants to humans. The function is unknown.


Pssm-ID: 370865  Cd Length: 113  Bit Score: 58.81  E-value: 6.63e-11
                          10        20        30
                  ....*....|....*....|....*....|....
gi 2462494865 330 SVMYERLRQELPKLFLQSHDYSLYSLDVEFINEI 363
Cdd:pfam10184   1 ADVVEILREDLPRLFPKDQDYSIYSEDVYFIDPL 34
PHA03247 PHA03247
large tegument protein UL36; Provisional
 116-324 4.11e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 39.54  E-value: 4.11e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462494865  116 PDSPRLPVPRGDLKGRGREIRSPAAAPSrssPAQTRPAGRPQqPARLALGERSWQEGRPV---CTRFGPLRPGWQDGHAP 192
Cdd:PHA03247  2619 PDTHAPDPPPPSPSPAANEPDPHPPPTV---PPPERPRDDPA-PGRVSRPRRARRLGRAAqasSPPQRPRRRAARPTVGS 2694

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462494865  193 SRDGASRTPSGTEDQLYP-GTLPFPPLWPHSTTTTSPSSPLFWSPLPPRLPTQRLPQVPPLPLPQIQALSSAWVVLPPGK 271
Cdd:PHA03247  2695 LTSLADPPPPPPTPEPAPhALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAA 2774

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 2462494865  272 GEEGPGPELHSGCLDGLRSLFEGPPCPYPGAWIPFQVPG-----TAHPSPATPSGDPS 324
Cdd:PHA03247  2775 PAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLApaaalPPAASPAGPLPPPT 2832
 
Name Accession Description Interval E-value
DUF2358 pfam10184
Uncharacterized conserved protein (DUF2358); DUF2358 is a family of conserved proteins found ...
 330-363 6.63e-11

Uncharacterized conserved protein (DUF2358); DUF2358 is a family of conserved proteins found from plants to humans. The function is unknown.


Pssm-ID: 370865  Cd Length: 113  Bit Score: 58.81  E-value: 6.63e-11
                          10        20        30
                  ....*....|....*....|....*....|....
gi 2462494865 330 SVMYERLRQELPKLFLQSHDYSLYSLDVEFINEI 363
Cdd:pfam10184   1 ADVVEILREDLPRLFPKDQDYSIYSEDVYFIDPL 34
PHA03247 PHA03247
large tegument protein UL36; Provisional
 116-324 4.11e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 39.54  E-value: 4.11e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462494865  116 PDSPRLPVPRGDLKGRGREIRSPAAAPSrssPAQTRPAGRPQqPARLALGERSWQEGRPV---CTRFGPLRPGWQDGHAP 192
Cdd:PHA03247  2619 PDTHAPDPPPPSPSPAANEPDPHPPPTV---PPPERPRDDPA-PGRVSRPRRARRLGRAAqasSPPQRPRRRAARPTVGS 2694

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462494865  193 SRDGASRTPSGTEDQLYP-GTLPFPPLWPHSTTTTSPSSPLFWSPLPPRLPTQRLPQVPPLPLPQIQALSSAWVVLPPGK 271
Cdd:PHA03247  2695 LTSLADPPPPPPTPEPAPhALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAA 2774

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 2462494865  272 GEEGPGPELHSGCLDGLRSLFEGPPCPYPGAWIPFQVPG-----TAHPSPATPSGDPS 324
Cdd:PHA03247  2775 PAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLApaaalPPAASPAGPLPPPT 2832
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH