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Conserved domains on  [gi|2462496347|ref|XP_054187665|]
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S-arrestin isoform X3 [Homo sapiens]

Protein Classification

arrestin family protein( domain architecture ID 10432337)

arrestin family protein with both N-terminal and C-terminal Ig-like beta-sandwich domains found in arrestin (S antigen)

CATH:  2.60.40.840
PubMed:  7720881|7833798
SCOP:  4007521

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Arrestin_C smart01017
Arrestin (or S-antigen), C-terminal domain; Ig-like beta-sandwich fold. Scop reports ...
 103-264 4.36e-32

Arrestin (or S-antigen), C-terminal domain; Ig-like beta-sandwich fold. Scop reports duplication with N-terminal domain. Arrestins comprise a family of closely-related proteins that includes beta-arrestin-1 and -2, which regulate the function of beta-adrenergic receptors by binding to their phosphorylated forms, impairing their capacity to activate G(S) proteins; Cone photoreceptors C-arrestin (arrestin-X). which could bind to phosphorylated red/green opsins; and Drosophila phosrestins I and II, which undergo light-induced phosphorylation, and probably play a role in photoreceptor transduction.


:

Pssm-ID: 214976 [Multi-domain]  Cd Length: 142  Bit Score: 116.29  E-value: 4.36e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496347  103 SDKPLHLAVSLNKEIYFHGEPIPVTVTVTNNTEKTVKKIKAFVEQVANVvlYSSDYYVKPVAMEEAQEKVPPNSTLTKTL 182
Cdd:smart01017   1 WSGPLSLEVSLPKKGYVPGETIPVTIKITNLSKKTVKKIKVSLVQTVTY--VSSDGPVKRSLAEKSKEKKADRKTLVKEL 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496347  183 TLLPLLANNRERRgialDGKIKHEDTNLAsstiikegiDRTVLGILVSYQIKVKLTVSGFlgeltSSEVATEVPFRLMHP 262
Cdd:smart01017  79 DGGPVLPGNKDKF----EGQLKVPPLPPT---------SRTCRLIKVEYKLKVKLRLSGK-----HSELRLELPITIGTV 140


                   ..
gi 2462496347  263 QP 264
Cdd:smart01017 141 PL 142
Arrestin_N super family cl22903
Arrestin (or S-antigen), N-terminal domain; Ig-like beta-sandwich fold. Scop reports ...
 23-84 2.60e-04

Arrestin (or S-antigen), N-terminal domain; Ig-like beta-sandwich fold. Scop reports duplication with C-terminal domain.


The actual alignment was detected with superfamily member pfam00339:

Pssm-ID: 451447  Cd Length: 148  Bit Score: 40.35  E-value: 2.60e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462496347  23 TLQFPDYLPCSVmlqpapqdSGKSCGVDFEVKAFATDStdaeeDKIPKKSS-VRLLIRKVQHA 84
Cdd:pfam00339  99 SFTLPPNCPSSF--------EGKHGGIRYEVKVTLDRP-----WKFNKSFRrVFTVIPKLDLN 148
 
Name Accession Description Interval E-value
Arrestin_C smart01017
Arrestin (or S-antigen), C-terminal domain; Ig-like beta-sandwich fold. Scop reports ...
 103-264 4.36e-32

Arrestin (or S-antigen), C-terminal domain; Ig-like beta-sandwich fold. Scop reports duplication with N-terminal domain. Arrestins comprise a family of closely-related proteins that includes beta-arrestin-1 and -2, which regulate the function of beta-adrenergic receptors by binding to their phosphorylated forms, impairing their capacity to activate G(S) proteins; Cone photoreceptors C-arrestin (arrestin-X). which could bind to phosphorylated red/green opsins; and Drosophila phosrestins I and II, which undergo light-induced phosphorylation, and probably play a role in photoreceptor transduction.


Pssm-ID: 214976 [Multi-domain]  Cd Length: 142  Bit Score: 116.29  E-value: 4.36e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496347  103 SDKPLHLAVSLNKEIYFHGEPIPVTVTVTNNTEKTVKKIKAFVEQVANVvlYSSDYYVKPVAMEEAQEKVPPNSTLTKTL 182
Cdd:smart01017   1 WSGPLSLEVSLPKKGYVPGETIPVTIKITNLSKKTVKKIKVSLVQTVTY--VSSDGPVKRSLAEKSKEKKADRKTLVKEL 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496347  183 TLLPLLANNRERRgialDGKIKHEDTNLAsstiikegiDRTVLGILVSYQIKVKLTVSGFlgeltSSEVATEVPFRLMHP 262
Cdd:smart01017  79 DGGPVLPGNKDKF----EGQLKVPPLPPT---------SRTCRLIKVEYKLKVKLRLSGK-----HSELRLELPITIGTV 140


                   ..
gi 2462496347  263 QP 264
Cdd:smart01017 141 PL 142
Arrestin_C pfam02752
Arrestin (or S-antigen), C-terminal domain; Ig-like beta-sandwich fold. Scop reports ...
 103-264 2.95e-14

Arrestin (or S-antigen), C-terminal domain; Ig-like beta-sandwich fold. Scop reports duplication with N-terminal domain.


Pssm-ID: 460676  Cd Length: 135  Bit Score: 68.51  E-value: 2.95e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496347 103 SDKPLHLAVSLNKEIYFHGEPIPVTVTVTNNTEKTVKKIKA-FVEQV---ANVVLYSSDYYVKPVAmEEAQEKVPPNStl 178
Cdd:pfam02752   1 WSGKVSYSVSLPKKGYVPGETIPVTIEIDNQSKKKIKKIKIsLVQQLtykAKTPLGESKREERVVA-KEKNPGVAPGS-- 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496347 179 tktltllpllannrerrgialDGKIKHEDT-----NLASSTIIKEGIDrtvlgilVSYQIKVKLTVSGFLGELTssevaT 253
Cdd:pfam02752  78 ---------------------KDKWEKELQlqiptDLPPSSTKCKIIK-------VEYKLKVTVDLSGSASELR-----L 124

                         170
                  ....*....|.
gi 2462496347 254 EVPFRLMHPQP 264
Cdd:pfam02752 125 ELPITIGTSPL 135
Arrestin_N pfam00339
Arrestin (or S-antigen), N-terminal domain; Ig-like beta-sandwich fold. Scop reports ...
 23-84 2.60e-04

Arrestin (or S-antigen), N-terminal domain; Ig-like beta-sandwich fold. Scop reports duplication with C-terminal domain.


Pssm-ID: 425619  Cd Length: 148  Bit Score: 40.35  E-value: 2.60e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462496347  23 TLQFPDYLPCSVmlqpapqdSGKSCGVDFEVKAFATDStdaeeDKIPKKSS-VRLLIRKVQHA 84
Cdd:pfam00339  99 SFTLPPNCPSSF--------EGKHGGIRYEVKVTLDRP-----WKFNKSFRrVFTVIPKLDLN 148
FliD COG1345
Flagellar capping protein FliD [Cell motility];
125-147 2.95e-03

Flagellar capping protein FliD [Cell motility];


Pssm-ID: 440956 [Multi-domain]  Cd Length: 450  Bit Score: 39.05  E-value: 2.95e-03
                          10        20
                  ....*....|....*....|...
gi 2462496347 125 PVTVTVTNNTEKTVKKIKAFVEQ 147
Cdd:COG1345   250 PVTLTVSTDTDAIKKAIKDFVDA 272
 
Name Accession Description Interval E-value
Arrestin_C smart01017
Arrestin (or S-antigen), C-terminal domain; Ig-like beta-sandwich fold. Scop reports ...
 103-264 4.36e-32

Arrestin (or S-antigen), C-terminal domain; Ig-like beta-sandwich fold. Scop reports duplication with N-terminal domain. Arrestins comprise a family of closely-related proteins that includes beta-arrestin-1 and -2, which regulate the function of beta-adrenergic receptors by binding to their phosphorylated forms, impairing their capacity to activate G(S) proteins; Cone photoreceptors C-arrestin (arrestin-X). which could bind to phosphorylated red/green opsins; and Drosophila phosrestins I and II, which undergo light-induced phosphorylation, and probably play a role in photoreceptor transduction.


Pssm-ID: 214976 [Multi-domain]  Cd Length: 142  Bit Score: 116.29  E-value: 4.36e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496347  103 SDKPLHLAVSLNKEIYFHGEPIPVTVTVTNNTEKTVKKIKAFVEQVANVvlYSSDYYVKPVAMEEAQEKVPPNSTLTKTL 182
Cdd:smart01017   1 WSGPLSLEVSLPKKGYVPGETIPVTIKITNLSKKTVKKIKVSLVQTVTY--VSSDGPVKRSLAEKSKEKKADRKTLVKEL 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496347  183 TLLPLLANNRERRgialDGKIKHEDTNLAsstiikegiDRTVLGILVSYQIKVKLTVSGFlgeltSSEVATEVPFRLMHP 262
Cdd:smart01017  79 DGGPVLPGNKDKF----EGQLKVPPLPPT---------SRTCRLIKVEYKLKVKLRLSGK-----HSELRLELPITIGTV 140


                   ..
gi 2462496347  263 QP 264
Cdd:smart01017 141 PL 142
Arrestin_C pfam02752
Arrestin (or S-antigen), C-terminal domain; Ig-like beta-sandwich fold. Scop reports ...
 103-264 2.95e-14

Arrestin (or S-antigen), C-terminal domain; Ig-like beta-sandwich fold. Scop reports duplication with N-terminal domain.


Pssm-ID: 460676  Cd Length: 135  Bit Score: 68.51  E-value: 2.95e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496347 103 SDKPLHLAVSLNKEIYFHGEPIPVTVTVTNNTEKTVKKIKA-FVEQV---ANVVLYSSDYYVKPVAmEEAQEKVPPNStl 178
Cdd:pfam02752   1 WSGKVSYSVSLPKKGYVPGETIPVTIEIDNQSKKKIKKIKIsLVQQLtykAKTPLGESKREERVVA-KEKNPGVAPGS-- 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496347 179 tktltllpllannrerrgialDGKIKHEDT-----NLASSTIIKEGIDrtvlgilVSYQIKVKLTVSGFLGELTssevaT 253
Cdd:pfam02752  78 ---------------------KDKWEKELQlqiptDLPPSSTKCKIIK-------VEYKLKVTVDLSGSASELR-----L 124

                         170
                  ....*....|.
gi 2462496347 254 EVPFRLMHPQP 264
Cdd:pfam02752 125 ELPITIGTSPL 135
Arrestin_N pfam00339
Arrestin (or S-antigen), N-terminal domain; Ig-like beta-sandwich fold. Scop reports ...
 23-84 2.60e-04

Arrestin (or S-antigen), N-terminal domain; Ig-like beta-sandwich fold. Scop reports duplication with C-terminal domain.


Pssm-ID: 425619  Cd Length: 148  Bit Score: 40.35  E-value: 2.60e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462496347  23 TLQFPDYLPCSVmlqpapqdSGKSCGVDFEVKAFATDStdaeeDKIPKKSS-VRLLIRKVQHA 84
Cdd:pfam00339  99 SFTLPPNCPSSF--------EGKHGGIRYEVKVTLDRP-----WKFNKSFRrVFTVIPKLDLN 148
FliD COG1345
Flagellar capping protein FliD [Cell motility];
125-147 2.95e-03

Flagellar capping protein FliD [Cell motility];


Pssm-ID: 440956 [Multi-domain]  Cd Length: 450  Bit Score: 39.05  E-value: 2.95e-03
                          10        20
                  ....*....|....*....|...
gi 2462496347 125 PVTVTVTNNTEKTVKKIKAFVEQ 147
Cdd:COG1345   250 PVTLTVSTDTDAIKKAIKDFVDA 272
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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