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Conserved domains on  [gi|2462508382|ref|XP_054192189|]
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telomere zinc finger-associated protein isoform X3 [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11473500)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11179890|12665246|10940247|11361095|22803940
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
154-215 1.57e-06

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 49.69  E-value: 1.57e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462508382 154 RPHVCEFCSHAFTQKANLNMHLRTHTGEKPFQCHL--CGKTFRTQASLDKHNRTHTGERPFSCE 215
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNS 95
SFP1 super family cl25788
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 65-150 5.61e-06

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


The actual alignment was detected with superfamily member COG5189:

Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 48.18  E-value: 5.61e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462508382  65 GEMPYKCS--SCSQQFMQKKDLQSHMIKLHGAPKPHACPTCAKcflsrtelqlHEAFKHRgEKLFVCEECGHRASSRNGL 142
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHMLHGHQNQKLHENPSPEK----------MNIFSAK-DKPYRCEVCDKRYKNLNGL 414


                  ....*...
gi 2462508382 143 QMHIKAKH 150
Cdd:COG5189   415 KYHRKHSH 422
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 269-291 4.11e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


:

Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 4.11e-03
                          10        20
                  ....*....|....*....|...
gi 2462508382 269 FECTECGYKFTRQAHLRRHMEIH 291
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
256-280 4.68e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 4.68e-03
                          10        20
                  ....*....|....*....|....*
gi 2462508382 256 LRVHVRRHKGVRKFECTECGYKFTR 280
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
154-215 1.57e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 49.69  E-value: 1.57e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462508382 154 RPHVCEFCSHAFTQKANLNMHLRTHTGEKPFQCHL--CGKTFRTQASLDKHNRTHTGERPFSCE 215
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNS 95
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 65-150 5.61e-06

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 48.18  E-value: 5.61e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462508382  65 GEMPYKCS--SCSQQFMQKKDLQSHMIKLHGAPKPHACPTCAKcflsrtelqlHEAFKHRgEKLFVCEECGHRASSRNGL 142
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHMLHGHQNQKLHENPSPEK----------MNIFSAK-DKPYRCEVCDKRYKNLNGL 414


                  ....*...
gi 2462508382 143 QMHIKAKH 150
Cdd:COG5189   415 KYHRKHSH 422
zf-H2C2_2 pfam13465
Zinc-finger double domain;
170-195 1.51e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 1.51e-04
                          10        20
                  ....*....|....*....|....*.
gi 2462508382 170 NLNMHLRTHTGEKPFQCHLCGKTFRT 195
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 269-291 4.11e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 4.11e-03
                          10        20
                  ....*....|....*....|...
gi 2462508382 269 FECTECGYKFTRQAHLRRHMEIH 291
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
256-280 4.68e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 4.68e-03
                          10        20
                  ....*....|....*....|....*
gi 2462508382 256 LRVHVRRHKGVRKFECTECGYKFTR 280
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
154-215 1.57e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 49.69  E-value: 1.57e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462508382 154 RPHVCEFCSHAFTQKANLNMHLRTHTGEKPFQCHL--CGKTFRTQASLDKHNRTHTGERPFSCE 215
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNS 95
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
155-303 4.03e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.54  E-value: 4.03e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462508382 155 PHVCEFCSHAFTQKANLNMHLRT--HTGE--KPFQC--HLCGKTFRTQASLDKHNRTHTGERPFSCEFCEQRFTEKGPLL 228
Cdd:COG5048   289 PIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLN 368

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462508382 229 -RHVASRHQEGRPH----FC---QICGKTFKAVEQLRVHVRRHKGVR--KFECTECGYKFTRQAHLRRHMEIHDRVENYN 298
Cdd:COG5048   369 nEPPQSLQQYKDLKndkkSEtlsNSCIRNFKRDSNLSLHIITHLSFRpyNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLL 448


                  ....*
gi 2462508382 299 PRQRK 303
Cdd:COG5048   449 CSILK 453
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 65-150 5.61e-06

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 48.18  E-value: 5.61e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462508382  65 GEMPYKCS--SCSQQFMQKKDLQSHMIKLHGAPKPHACPTCAKcflsrtelqlHEAFKHRgEKLFVCEECGHRASSRNGL 142
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHMLHGHQNQKLHENPSPEK----------MNIFSAK-DKPYRCEVCDKRYKNLNGL 414


                  ....*...
gi 2462508382 143 QMHIKAKH 150
Cdd:COG5189   415 KYHRKHSH 422
zf-H2C2_2 pfam13465
Zinc-finger double domain;
170-195 1.51e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 1.51e-04
                          10        20
                  ....*....|....*....|....*.
gi 2462508382 170 NLNMHLRTHTGEKPFQCHLCGKTFRT 195
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
35-204 6.95e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.61  E-value: 6.95e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462508382  35 NRSEQVFTCSVCQETFRRRMELRVHM--VSHTGE--MPYKCSS--CSQQFMQKKDLQSHmIKLHGAPKPHACPTCA---- 104
Cdd:COG5048   284 KGFSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRH-ILLHTSISPAKEKLLNsssk 362

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462508382 105 --KCFLSRTELQLHEAFKHRGEKLFVCE--ECGHRASSRNGLQMHIKaKHRNERPHVCEF--CSHAFTQKANLNMHLRTH 178
Cdd:COG5048   363 fsPLLNNEPPQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHII-THLSFRPYNCKNppCSKSFNRHYNLIPHKKIH 441

                         170       180
                  ....*....|....*....|....*.
gi 2462508382 179 TGEKPFQCHLCGKTFRTQaSLDKHNR 204
Cdd:COG5048   442 TNHAPLLCSILKSFRRDL-DLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
72-156 1.50e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.45  E-value: 1.50e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462508382  72 SSCSQQFMQKKdlQSHMIKLHGAPKPHACPTCAKCFlSRTELQLHEAFKHRGEKLFVCEECGHRASSRNGLQMHIKAKHR 151
Cdd:COG5048    10 SSNNSVLSSTP--KSTLKSLSNAPRPDSCPNCTDSF-SRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTH 86


                  ....*
gi 2462508382 152 NERPH 156
Cdd:COG5048    87 HNNPS 91
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 269-291 4.11e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 4.11e-03
                          10        20
                  ....*....|....*....|...
gi 2462508382 269 FECTECGYKFTRQAHLRRHMEIH 291
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
256-280 4.68e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 4.68e-03
                          10        20
                  ....*....|....*....|....*
gi 2462508382 256 LRVHVRRHKGVRKFECTECGYKFTR 280
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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