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Conserved domains on  [gi|2462508730|ref|XP_054192356|]
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regulator of G-protein signaling protein-like isoform X5 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RGS-like_2 cd08728
Uncharacterized Regulator of G protein Signaling (RGS) domain subfamily, child 2; These ...
 685-864 4.88e-90

Uncharacterized Regulator of G protein Signaling (RGS) domain subfamily, child 2; These uncharacterized RGS-like domains consists largely of hypothetical proteins. The RGS domain is an essential part of the Regulator of G-protein Signaling (RGS) protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. Several RGS proteins can fine-tune immune responses, while others play an important role in neuronal signal modulation. Some RGS proteins are the principal elements needed for proper vision.


:

Pssm-ID: 188683  Cd Length: 179  Bit Score: 284.43  E-value: 4.88e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462508730 685 LLNTQHLEFFREFLKERKAKIPLQFLTAVQKISIETNEKICKSLIENVIKTFFQGQLSPEEMLQCDAPIIKEIASMRHVT 764
Cdd:cd08728     1 LRNHTHLEYFKRFLKSRGSDGPLLFWIAVEKMRVEENEKEQKAKIELIVKRYFHGQDPPGVLLQCEAIIIREIAMMKVVT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462508730 765 TSTLLTLQGHVMKSIEEKWFKDYQDLFPPHHQEVEVQSEVQISSRKPSKIVSTYLqESQKKGWMRMISFIRSFCKYRRFM 844
Cdd:cd08728    81 TSMLLSIQHLVSKSLEERWFKKYQDTFPDCPHEVEPDEEIKVPLKPTKLKAPHVI-SSQKRAWEIFISFIRSFIKFRRFM 159

                         170       180
                  ....*....|....*....|
gi 2462508730 845 LNPSKRQEFEDYLHQEMQNS 864
Cdd:cd08728   160 VNREIRQEFEDYLVQEMENY 179
 
Name Accession Description Interval E-value
RGS-like_2 cd08728
Uncharacterized Regulator of G protein Signaling (RGS) domain subfamily, child 2; These ...
 685-864 4.88e-90

Uncharacterized Regulator of G protein Signaling (RGS) domain subfamily, child 2; These uncharacterized RGS-like domains consists largely of hypothetical proteins. The RGS domain is an essential part of the Regulator of G-protein Signaling (RGS) protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. Several RGS proteins can fine-tune immune responses, while others play an important role in neuronal signal modulation. Some RGS proteins are the principal elements needed for proper vision.


Pssm-ID: 188683  Cd Length: 179  Bit Score: 284.43  E-value: 4.88e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462508730 685 LLNTQHLEFFREFLKERKAKIPLQFLTAVQKISIETNEKICKSLIENVIKTFFQGQLSPEEMLQCDAPIIKEIASMRHVT 764
Cdd:cd08728     1 LRNHTHLEYFKRFLKSRGSDGPLLFWIAVEKMRVEENEKEQKAKIELIVKRYFHGQDPPGVLLQCEAIIIREIAMMKVVT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462508730 765 TSTLLTLQGHVMKSIEEKWFKDYQDLFPPHHQEVEVQSEVQISSRKPSKIVSTYLqESQKKGWMRMISFIRSFCKYRRFM 844
Cdd:cd08728    81 TSMLLSIQHLVSKSLEERWFKKYQDTFPDCPHEVEPDEEIKVPLKPTKLKAPHVI-SSQKRAWEIFISFIRSFIKFRRFM 159

                         170       180
                  ....*....|....*....|
gi 2462508730 845 LNPSKRQEFEDYLHQEMQNS 864
Cdd:cd08728   160 VNREIRQEFEDYLVQEMENY 179
 
Name Accession Description Interval E-value
RGS-like_2 cd08728
Uncharacterized Regulator of G protein Signaling (RGS) domain subfamily, child 2; These ...
 685-864 4.88e-90

Uncharacterized Regulator of G protein Signaling (RGS) domain subfamily, child 2; These uncharacterized RGS-like domains consists largely of hypothetical proteins. The RGS domain is an essential part of the Regulator of G-protein Signaling (RGS) protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. Several RGS proteins can fine-tune immune responses, while others play an important role in neuronal signal modulation. Some RGS proteins are the principal elements needed for proper vision.


Pssm-ID: 188683  Cd Length: 179  Bit Score: 284.43  E-value: 4.88e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462508730 685 LLNTQHLEFFREFLKERKAKIPLQFLTAVQKISIETNEKICKSLIENVIKTFFQGQLSPEEMLQCDAPIIKEIASMRHVT 764
Cdd:cd08728     1 LRNHTHLEYFKRFLKSRGSDGPLLFWIAVEKMRVEENEKEQKAKIELIVKRYFHGQDPPGVLLQCEAIIIREIAMMKVVT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462508730 765 TSTLLTLQGHVMKSIEEKWFKDYQDLFPPHHQEVEVQSEVQISSRKPSKIVSTYLqESQKKGWMRMISFIRSFCKYRRFM 844
Cdd:cd08728    81 TSMLLSIQHLVSKSLEERWFKKYQDTFPDCPHEVEPDEEIKVPLKPTKLKAPHVI-SSQKRAWEIFISFIRSFIKFRRFM 159

                         170       180
                  ....*....|....*....|
gi 2462508730 845 LNPSKRQEFEDYLHQEMQNS 864
Cdd:cd08728   160 VNREIRQEFEDYLVQEMENY 179
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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