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Conserved domains on  [gi|2462509032|ref|XP_054192498|]
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protein SPO16 homolog isoform X2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SCRE super family cl21028
Protein SPO16 homolog; This entry represents the Protein SPO16 homolog (SPO16, also known as ...
 1-111 8.44e-73

Protein SPO16 homolog; This entry represents the Protein SPO16 homolog (SPO16, also known as Synaptonemal complex reinforcing element SCRE), including the mammalian orthologue of budding yeast Spo16. It plays a key role in reinforcing the integrity of the central element of the synaptonemal complex (SC), resulting in the SC stabilization which ensures the progression of meiotic prophase I in male and female germ cells. It promotes homologous recombination and crossing-over in meiotic prophase I via its association with SHOC1. It is also required for the localization of TEX11 and MSH4 to recombination intermediates.


The actual alignment was detected with superfamily member pfam15162:

Pssm-ID: 464538  Cd Length: 162  Bit Score: 213.80  E-value: 8.44e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462509032   1 MDTKECLLSTEEIFLAKIEKFINIHQNSFLVLSAALHGPEEWKLMFRIQQRFLGCNLRILPVHNTVNAINLMCTIAKTTS 80
Cdd:pfam15162  52 VDAQDLFKSAEEGFFERIEKFIQIHRNSFLLLSAALHGPREWEVMFRIQQRFLGSNLRILPVHNTAEIVKLMLTIAKATS 131

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2462509032  81 KPYIDSICYRMITAKAYIIEQSPVWKTLQKI 111
Cdd:pfam15162 132 KPHVDSIRYRMALAKAQIIEQSPVWEMLQKL 162
 
Name Accession Description Interval E-value
SCRE pfam15162
Protein SPO16 homolog; This entry represents the Protein SPO16 homolog (SPO16, also known as ...
 1-111 8.44e-73

Protein SPO16 homolog; This entry represents the Protein SPO16 homolog (SPO16, also known as Synaptonemal complex reinforcing element SCRE), including the mammalian orthologue of budding yeast Spo16. It plays a key role in reinforcing the integrity of the central element of the synaptonemal complex (SC), resulting in the SC stabilization which ensures the progression of meiotic prophase I in male and female germ cells. It promotes homologous recombination and crossing-over in meiotic prophase I via its association with SHOC1. It is also required for the localization of TEX11 and MSH4 to recombination intermediates.


Pssm-ID: 464538  Cd Length: 162  Bit Score: 213.80  E-value: 8.44e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462509032   1 MDTKECLLSTEEIFLAKIEKFINIHQNSFLVLSAALHGPEEWKLMFRIQQRFLGCNLRILPVHNTVNAINLMCTIAKTTS 80
Cdd:pfam15162  52 VDAQDLFKSAEEGFFERIEKFIQIHRNSFLLLSAALHGPREWEVMFRIQQRFLGSNLRILPVHNTAEIVKLMLTIAKATS 131

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2462509032  81 KPYIDSICYRMITAKAYIIEQSPVWKTLQKI 111
Cdd:pfam15162 132 KPHVDSIRYRMALAKAQIIEQSPVWEMLQKL 162
 
Name Accession Description Interval E-value
SCRE pfam15162
Protein SPO16 homolog; This entry represents the Protein SPO16 homolog (SPO16, also known as ...
 1-111 8.44e-73

Protein SPO16 homolog; This entry represents the Protein SPO16 homolog (SPO16, also known as Synaptonemal complex reinforcing element SCRE), including the mammalian orthologue of budding yeast Spo16. It plays a key role in reinforcing the integrity of the central element of the synaptonemal complex (SC), resulting in the SC stabilization which ensures the progression of meiotic prophase I in male and female germ cells. It promotes homologous recombination and crossing-over in meiotic prophase I via its association with SHOC1. It is also required for the localization of TEX11 and MSH4 to recombination intermediates.


Pssm-ID: 464538  Cd Length: 162  Bit Score: 213.80  E-value: 8.44e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462509032   1 MDTKECLLSTEEIFLAKIEKFINIHQNSFLVLSAALHGPEEWKLMFRIQQRFLGCNLRILPVHNTVNAINLMCTIAKTTS 80
Cdd:pfam15162  52 VDAQDLFKSAEEGFFERIEKFIQIHRNSFLLLSAALHGPREWEVMFRIQQRFLGSNLRILPVHNTAEIVKLMLTIAKATS 131

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2462509032  81 KPYIDSICYRMITAKAYIIEQSPVWKTLQKI 111
Cdd:pfam15162 132 KPHVDSIRYRMALAKAQIIEQSPVWEMLQKL 162
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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