NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2462512151|ref|XP_054194005|]
View 

leucine-rich repeat-containing G-protein coupled receptor 6 isoform X8 [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11471190)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
7tmA_LGR6 cd15362
leucine-rich repeats-containing G protein-coupled receptor 6, the class A of 7-transmembrane ...
 447-719 7.53e-164

leucine-rich repeats-containing G protein-coupled receptor 6, the class A of 7-transmembrane GPCRs; The leucine-rich repeat containing G-protein coupled receptor LGR5, together with its family members LGR4 and LGR6, is structurally related to the glycoprotein hormone receptor family, which includes the luteinizing hormone (LH) receptor, the follicle-stimulating hormone (FSH) receptor, and the pituitary thyroid-stimulating hormone (TSH) receptor. LGR4-6 are receptors for the R-spondin (Rspo) family of secreted proteins containing two N-terminal furin-like repeats and a thrombospondin domain. The Rspo proteins are involved in regulating proliferation and differentiation of adult stem cells by potently enhancing the WNT-stimulated beta-catenin signaling. LGR5 serves as a marker for resident stem cell in numerous epithelial cell layers, including small intestine, colon, stomach, and kidney. LGR6 is a marker for multipotent stem cells in the hair follicle that generate all skin cell lineages. In addition, LGR4 is broadly expressed in proliferating cells, and its deficient mice display development defects in multiple organs. Members of this group are characterized by a very large extracellular N-terminal domain containing 17 leucine-rich repeats (LRRs), flanked by cysteine-rich N- and C-terminal capping domains, and the extracellular domain is responsible for high-affinity binding with the Rspo proteins.


:

Pssm-ID: 320484  Cd Length: 276  Bit Score: 476.98  E-value: 7.53e-164
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512151 447 WGIRLAVWAIVLLSVLCNGLVLLTVFAGgPAPLPPVKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLG 526
Cdd:cd15362     1 WVVRLGVWAIVLVSVLCNGLVILTVFAS-PGYLSPVKFVIGSIAGANLLTGICTGTLALVDALTFGQFAKYGARWETGLG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512151 527 CRATGFLAVLGSEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASVGEYGASPLCLPYA 606
Cdd:cd15362    80 CRATGFLSVFASEASILLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAAALCCLALSLTAAALPLFSVGEYGASPLCLPSP 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512151 607 PPEGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFEAVWDCAMVRHVAWLIFADGLLYCPVAFLSFASMLGLF 686
Cdd:cd15362   160 LPDGKPSTLGFTVALIMMNTLCFLVITGTYIKLYCDLLKGEFDAIWDCAMIKHVAWLIFTNCLLYCPVAFLTFSSLLNLF 239

                         250       260       270
                  ....*....|....*....|....*....|...
gi 2462512151 687 PVTPEAVKSVLLVVLPLPACLNPLLYLLFNPHF 719
Cdd:cd15362   240 PISPEVIKSVLLVVLPLPACLNPLLYLLFNPHF 272
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
33-342 6.20e-34

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 135.45  E-value: 6.20e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512151  33 NNLTELQPGLFHHLRFLEELRLSGNhlshipgQAFSGLYSLKILMLQNNQLGGIPAEaLWELPSLQSLRLDANLISLVPE 112
Cdd:COG4886    82 LSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDLPEE-LANLTNLKELDLSNNQLTDLPE 153

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512151 113 rSFEGLSSLRHLWLDDNALTEIPvRALNNLPALQAMTLALNRISHIPDyAFQNLTSLVVLDLNYNKLQEFPVAIRTLGRL 192
Cdd:COG4886   154 -PLGNLTNLKSLDLSNNQLTDLP-EELGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQLTDLPEPLANLTNL 230

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512151 193 QELGFHNNNIKAIPEKAfmgnpllqtihfydnpiqfvgrsafqylpklhtlslngamdiqefpdlkgttsleiltltrag 272
Cdd:COG4886   231 ETLDLSNNQLTDLPELG--------------------------------------------------------------- 247

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512151 273 irllpsgmcqQLPRLRVLELSHNQIEELPSLHRCQKLEEMDLTDNQLTTLPLAGLGGLMHLKLKGNLALS 342
Cdd:COG4886   248 ----------NLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLL 307
LRR_8 pfam13855
Leucine rich repeat;
191-247 1.09e-06

Leucine rich repeat;


:

Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 46.36  E-value: 1.09e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462512151 191 RLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNG 247
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSG 58
 
Name Accession Description Interval E-value
7tmA_LGR6 cd15362
leucine-rich repeats-containing G protein-coupled receptor 6, the class A of 7-transmembrane ...
 447-719 7.53e-164

leucine-rich repeats-containing G protein-coupled receptor 6, the class A of 7-transmembrane GPCRs; The leucine-rich repeat containing G-protein coupled receptor LGR5, together with its family members LGR4 and LGR6, is structurally related to the glycoprotein hormone receptor family, which includes the luteinizing hormone (LH) receptor, the follicle-stimulating hormone (FSH) receptor, and the pituitary thyroid-stimulating hormone (TSH) receptor. LGR4-6 are receptors for the R-spondin (Rspo) family of secreted proteins containing two N-terminal furin-like repeats and a thrombospondin domain. The Rspo proteins are involved in regulating proliferation and differentiation of adult stem cells by potently enhancing the WNT-stimulated beta-catenin signaling. LGR5 serves as a marker for resident stem cell in numerous epithelial cell layers, including small intestine, colon, stomach, and kidney. LGR6 is a marker for multipotent stem cells in the hair follicle that generate all skin cell lineages. In addition, LGR4 is broadly expressed in proliferating cells, and its deficient mice display development defects in multiple organs. Members of this group are characterized by a very large extracellular N-terminal domain containing 17 leucine-rich repeats (LRRs), flanked by cysteine-rich N- and C-terminal capping domains, and the extracellular domain is responsible for high-affinity binding with the Rspo proteins.


Pssm-ID: 320484  Cd Length: 276  Bit Score: 476.98  E-value: 7.53e-164
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512151 447 WGIRLAVWAIVLLSVLCNGLVLLTVFAGgPAPLPPVKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLG 526
Cdd:cd15362     1 WVVRLGVWAIVLVSVLCNGLVILTVFAS-PGYLSPVKFVIGSIAGANLLTGICTGTLALVDALTFGQFAKYGARWETGLG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512151 527 CRATGFLAVLGSEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASVGEYGASPLCLPYA 606
Cdd:cd15362    80 CRATGFLSVFASEASILLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAAALCCLALSLTAAALPLFSVGEYGASPLCLPSP 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512151 607 PPEGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFEAVWDCAMVRHVAWLIFADGLLYCPVAFLSFASMLGLF 686
Cdd:cd15362   160 LPDGKPSTLGFTVALIMMNTLCFLVITGTYIKLYCDLLKGEFDAIWDCAMIKHVAWLIFTNCLLYCPVAFLTFSSLLNLF 239

                         250       260       270
                  ....*....|....*....|....*....|...
gi 2462512151 687 PVTPEAVKSVLLVVLPLPACLNPLLYLLFNPHF 719
Cdd:cd15362   240 PISPEVIKSVLLVVLPLPACLNPLLYLLFNPHF 272
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
33-342 6.20e-34

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 135.45  E-value: 6.20e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512151  33 NNLTELQPGLFHHLRFLEELRLSGNhlshipgQAFSGLYSLKILMLQNNQLGGIPAEaLWELPSLQSLRLDANLISLVPE 112
Cdd:COG4886    82 LSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDLPEE-LANLTNLKELDLSNNQLTDLPE 153

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512151 113 rSFEGLSSLRHLWLDDNALTEIPvRALNNLPALQAMTLALNRISHIPDyAFQNLTSLVVLDLNYNKLQEFPVAIRTLGRL 192
Cdd:COG4886   154 -PLGNLTNLKSLDLSNNQLTDLP-EELGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQLTDLPEPLANLTNL 230

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512151 193 QELGFHNNNIKAIPEKAfmgnpllqtihfydnpiqfvgrsafqylpklhtlslngamdiqefpdlkgttsleiltltrag 272
Cdd:COG4886   231 ETLDLSNNQLTDLPELG--------------------------------------------------------------- 247

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512151 273 irllpsgmcqQLPRLRVLELSHNQIEELPSLHRCQKLEEMDLTDNQLTTLPLAGLGGLMHLKLKGNLALS 342
Cdd:COG4886   248 ----------NLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLL 307
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 29-338 6.76e-20

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 95.30  E-value: 6.76e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512151  29 DLSMNNLTELQP---GLFHHLRFLEelrLSGNHLS-HIPGqAFSGLYSLKILMLQNNQL-GGIPAEaLWELPSLQSLRLD 103
Cdd:PLN00113  146 DLSNNMLSGEIPndiGSFSSLKVLD---LGGNVLVgKIPN-SLTNLTSLEFLTLASNQLvGQIPRE-LGQMKSLKWIYLG 220

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512151 104 ANLISLVPERSFEGLSSLRHLWLDDNALT-EIPVrALNNLPALQAMTLALNRIS-HIPDYAFqNLTSLVVLDLNYNKLQ- 180
Cdd:PLN00113  221 YNNLSGEIPYEIGGLTSLNHLDLVYNNLTgPIPS-SLGNLKNLQYLFLYQNKLSgPIPPSIF-SLQKLISLDLSDNSLSg 298

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512151 181 EFPVAIRTLGRLQELG-FHNNNIKAIPEkAFMGNPLLQTIHFYDN------PIQFVGRSAFQYLpKLHTLSLNG------ 247
Cdd:PLN00113  299 EIPELVIQLQNLEILHlFSNNFTGKIPV-ALTSLPRLQVLQLWSNkfsgeiPKNLGKHNNLTVL-DLSTNNLTGeipegl 376

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512151 248 --------------AMDIQEFPDLKGTTSLEILTLTRAGIR-LLPSGMCQ-----------------------QLPRLRV 289
Cdd:PLN00113  377 cssgnlfklilfsnSLEGEIPKSLGACRSLRRVRLQDNSFSgELPSEFTKlplvyfldisnnnlqgrinsrkwDMPSLQM 456

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2462512151 290 LELSHNQIE-ELPSLHRCQKLEEMDLTDNQLT-TLP--LAGLGGLMHLKLKGN 338
Cdd:PLN00113  457 LSLARNKFFgGLPDSFGSKRLENLDLSRNQFSgAVPrkLGSLSELMQLKLSEN 509
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 30-206 3.21e-14

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 72.51  E-value: 3.21e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512151  30 LSMN--NLTELqpGLFHHLRFLEELRLSGNHLSHIPGqaFSGLYSLKILMLQNNQLGGIpaEALWELPSLQSLRLDANLI 107
Cdd:cd21340     7 LYLNdkNITKI--DNLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKI--ENLENLVNLKKLYLGGNRI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512151 108 SLVpErSFEGLSSLRHLWLDDNALTE-----IPVRALNNL-PALQAMTLALNRISHIPDyaFQNLTSLVVLDLNYNKLQE 181
Cdd:cd21340    81 SVV-E-GLENLTNLEELHIENQRLPPgekltFDPRSLAALsNSLRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQISD 156

                         170       180
                  ....*....|....*....|....*...
gi 2462512151 182 FP---VAIRTLGRLQELGFHNNNIKAIP 206
Cdd:cd21340   157 LEellDLLSSWPSLRELDLTGNPVCKKP 184
LRR_8 pfam13855
Leucine rich repeat;
49-107 1.29e-13

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 66.01  E-value: 1.29e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462512151  49 LEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLRLDANLI 107
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
191-247 1.09e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 46.36  E-value: 1.09e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462512151 191 RLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNG 247
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSG 58
LRR smart00370
Leucine-rich repeats, outliers;
46-69 9.48e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 34.25  E-value: 9.48e-03
                           10        20
                   ....*....|....*....|....
gi 2462512151   46 LRFLEELRLSGNHLSHIPGQAFSG 69
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
 
Name Accession Description Interval E-value
7tmA_LGR6 cd15362
leucine-rich repeats-containing G protein-coupled receptor 6, the class A of 7-transmembrane ...
 447-719 7.53e-164

leucine-rich repeats-containing G protein-coupled receptor 6, the class A of 7-transmembrane GPCRs; The leucine-rich repeat containing G-protein coupled receptor LGR5, together with its family members LGR4 and LGR6, is structurally related to the glycoprotein hormone receptor family, which includes the luteinizing hormone (LH) receptor, the follicle-stimulating hormone (FSH) receptor, and the pituitary thyroid-stimulating hormone (TSH) receptor. LGR4-6 are receptors for the R-spondin (Rspo) family of secreted proteins containing two N-terminal furin-like repeats and a thrombospondin domain. The Rspo proteins are involved in regulating proliferation and differentiation of adult stem cells by potently enhancing the WNT-stimulated beta-catenin signaling. LGR5 serves as a marker for resident stem cell in numerous epithelial cell layers, including small intestine, colon, stomach, and kidney. LGR6 is a marker for multipotent stem cells in the hair follicle that generate all skin cell lineages. In addition, LGR4 is broadly expressed in proliferating cells, and its deficient mice display development defects in multiple organs. Members of this group are characterized by a very large extracellular N-terminal domain containing 17 leucine-rich repeats (LRRs), flanked by cysteine-rich N- and C-terminal capping domains, and the extracellular domain is responsible for high-affinity binding with the Rspo proteins.


Pssm-ID: 320484  Cd Length: 276  Bit Score: 476.98  E-value: 7.53e-164
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512151 447 WGIRLAVWAIVLLSVLCNGLVLLTVFAGgPAPLPPVKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLG 526
Cdd:cd15362     1 WVVRLGVWAIVLVSVLCNGLVILTVFAS-PGYLSPVKFVIGSIAGANLLTGICTGTLALVDALTFGQFAKYGARWETGLG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512151 527 CRATGFLAVLGSEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASVGEYGASPLCLPYA 606
Cdd:cd15362    80 CRATGFLSVFASEASILLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAAALCCLALSLTAAALPLFSVGEYGASPLCLPSP 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512151 607 PPEGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFEAVWDCAMVRHVAWLIFADGLLYCPVAFLSFASMLGLF 686
Cdd:cd15362   160 LPDGKPSTLGFTVALIMMNTLCFLVITGTYIKLYCDLLKGEFDAIWDCAMIKHVAWLIFTNCLLYCPVAFLTFSSLLNLF 239

                         250       260       270
                  ....*....|....*....|....*....|...
gi 2462512151 687 PVTPEAVKSVLLVVLPLPACLNPLLYLLFNPHF 719
Cdd:cd15362   240 PISPEVIKSVLLVVLPLPACLNPLLYLLFNPHF 272
7tmA_LRR_GPR cd15138
orphan leucine-rich repeat-containing G protein-coupled receptors, member of the class A ...
 447-719 7.79e-146

orphan leucine-rich repeat-containing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes leucine-rich repeat-containing G-protein coupled receptor 4 (LGR4), 5 (LGR5), and 6 (LGR6). These receptors contain a subfamily of receptors related to the glycoprotein hormone receptor family, which includes the luteinizing hormone (LH) receptor, the follicle-stimulating hormone (FSH) receptor, and the pituitary thyroid-stimulating hormone (TSH) receptor. LGR4-6 are receptors for the R-spondin (Rspo) family of secreted proteins containing two N-terminal furin-like repeats and a thrombospondin domain. The RSPO proteins are involved in regulating proliferation and differentiation of adult stem cells by potently enhancing the WNT-stimulated beta-catenin signaling. LGR4 is broadly expressed in proliferating cells, and its deficient mice display development defects in multiple organs. LGR5 acts as a marker for resident stem cell in numerous epithelial cell layers, including small intestine, colon, stomach, and kidney. LGR6 also serves as a marker of multipotent stem cells in the hair follicle that generate all skin cell lineages. Members of this group are characterized by a very large extracellular N-terminal domain containing 17 leucine-rich repeats (LRRs), flanked by cysteine-rich N- and C-terminal capping domains, and the extracellular domain is responsible for high-affinity binding with the Rspo proteins.


Pssm-ID: 320266  Cd Length: 274  Bit Score: 430.81  E-value: 7.79e-146
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512151 447 WGIRLAVWAIVLLSVLCNGLVLLTVFAGGPAPlPPVKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLG 526
Cdd:cd15138     1 WMIRLTVWFIFLLALFCNLLVILTVFASCTSL-PPSKLFIGLIAVSNLLTGISTGILAFVDAVTFGRFAEFGAWWETGSG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512151 527 CRATGFLAVLGSEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASVGEYGASPLCLPYA 606
Cdd:cd15138    80 CKVAGFLAVFSSESSVFLLTLAAVERSLSVKDIMKNGKSNHLKSFRVAALLCFLLATVAAAFPLFHRGEYGASPLCLPFP 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512151 607 PpeGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFEAVWDCAMVRHVAWLIFADGLLYCPVAFLSFASMLGLF 686
Cdd:cd15138   160 T--GEPPSLGFTVALVLLNSLCFLLMAVAYTKLYCNLEKGDLEENWDCSMVKHVAWLIFTNCILFCPVAFLSFASLITLI 237

                         250       260       270
                  ....*....|....*....|....*....|...
gi 2462512151 687 PVTPEAVKSVLLVVLPLPACLNPLLYLLFNPHF 719
Cdd:cd15138   238 SISPEIMKSVLLVVFPLPACLNPLLYVLFNPHF 270
7tmA_LGR5 cd15363
leucine-rich repeats-containing G protein-coupled receptor 5, member of the class A family of ...
 447-719 2.20e-95

leucine-rich repeats-containing G protein-coupled receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The leucine-rich repeat containing G-protein coupled receptor LGR6, together with its family members LGR4 and LGR5, is structurally related to the glycoprotein hormone receptor family, which includes the luteinizing hormone (LH) receptor, the follicle-stimulating hormone (FSH) receptor, and the pituitary thyroid-stimulating hormone (TSH) receptor. LGR4-6 are receptors for the R-spondin (Rspo) family of secreted proteins containing two N-terminal furin-like repeats and a thrombospondin domain. The Rspo proteins are involved in regulating proliferation and differentiation of adult stem cells by potently enhancing the WNT-stimulated beta-catenin signaling. LGR6 serves as a marker of multipotent stem cells in the hair follicle that generate all skin cell lineages, whereas LGR5 is a marker for resident stem cell in numerous epithelial cell layers, including small intestine, colon, stomach, and kidney. In addition, LGR4 is broadly expressed in proliferating cells, and its deficient mice display development defects in multiple organs. Members of this group are characterized by a very large extracellular N-terminal domain containing 17 leucine-rich repeats (LRRs), flanked by cysteine-rich N- and C-terminal capping domains, and the extracellular domain is responsible for high-affinity binding with the Rspo proteins.


Pssm-ID: 320485  Cd Length: 274  Bit Score: 299.84  E-value: 2.20e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512151 447 WGIRLAVWAIVLLSVLCNGLVLLTVFAGgPAPLPPVKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLG 526
Cdd:cd15363     1 WLIRIGVWTIAVLALVCNALVTATVFRS-PLYISSIKLLIGLIAIVNMLMGVSSAVLAGVDAFTFGSFAQHGAWWESGVG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512151 527 CRATGFLAVLGSEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASVGEYGASPLCLPYa 606
Cdd:cd15363    80 CQITGFLSIFASESSVFLLTLAALERGFSVKCSTKFETKSPFLSLKAIILLCFLLALTIAVIPLLGGSEYGASPLCLPL- 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512151 607 pPEGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFEAVWDCAMVRHVAWLIFADGLLYCPVAFLSFASMLGLF 686
Cdd:cd15363   159 -PFGEPSAMGYMVALVLLNSLCFLVMTIAYTKLYCSLEKGELENIWDCSMVKHIALLLFTNCILYCPVAFLSFSSLLNLT 237

                         250       260       270
                  ....*....|....*....|....*....|...
gi 2462512151 687 PVTPEAVKSVLLVVLPLPACLNPLLYLLFNPHF 719
Cdd:cd15363   238 FISPEVIKFILLVIVPLPACLNPLLYILFNPHF 270
7tmA_LGR4 cd15361
leucine-rich repeats-containing G protein-coupled receptor 4, member of the class A family of ...
 447-719 4.45e-76

leucine-rich repeats-containing G protein-coupled receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The leucine-rich repeat containing G-protein coupled receptor Lgr4 (formerly known as Gpr48), together with its close family members LGR5 and LGR6, is structurally related to the glycoprotein hormone receptor family, which includes the luteinizing hormone (LH) receptor, the follicle-stimulating hormone (FSH) receptor, and the pituitary thyroid-stimulating hormone (TSH) receptor. LGR4-6 are receptors for the R-spondin (Rspo) family of secreted proteins containing two N-terminal furin-like repeats and a thrombospondin domain. The Rspo proteins are involved in regulating proliferation and differentiation of adult stem cells by potently enhancing the WNT-stimulated beta-catenin signaling. LGR4 is broadly expressed in proliferating cells, and its deficient mice display development defects in multiple organs. LGR5 acts as a marker for resident stem cell in numerous epithelial cell layers, including small intestine, colon, stomach, and kidney. LGR6 also serves as a marker of multipotent stem cells in the hair follicle that generate all skin cell lineages. Members of this group are characterized by a very large extracellular N-terminal domain containing 17 leucine-rich repeats (LRRs), flanked by cysteine-rich N- and C-terminal capping domains, and the extracellular domain is responsible for high-affinity binding with the Rspo proteins.


Pssm-ID: 320483  Cd Length: 274  Bit Score: 248.62  E-value: 4.45e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512151 447 WGIRLAVWAIVLLSVLCNGLVLLTVFAGGpAPLPPVKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLG 526
Cdd:cd15361     1 WMIRLTVWFIFLVALFFNLLVILTTFASC-TSLPSSKLFVGLIAVSNLFMGVYTGILTFLDTVSWGRFAEFGIWWETGSG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512151 527 CRATGFLAVLGSEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASVGEYGASPLCLPYa 606
Cdd:cd15361    80 CKVAGFLAVFSSESAIFLLMLAAVERSLSAKDIMKKGKSNRLRQFQIAALLAFLVATAAGCLPLFHGGEYSASPLCLPF- 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512151 607 pPEGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFEAVWDCAMVRHVAWLIFADGLLYCPVAFLSFASMLGLF 686
Cdd:cd15361   159 -PTGETPSLGFTVTLVLLNSLAFLLMAVIYTKLYCNLEKEDLSENSQSSMIKHVAWLIFTNCIFFCPVAFFSFAPLITAI 237

                         250       260       270
                  ....*....|....*....|....*....|...
gi 2462512151 687 PVTPEAVKSVLLVVLPLPACLNPLLYLLFNPHF 719
Cdd:cd15361   238 SISPEIMKSVTLIFFPLPACLNPVLYVFFNPKF 270
7tmA_Glycoprotein_LRR_R-like cd14980
glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, ...
 447-719 4.03e-39

glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the glycoprotein hormone receptors (GPHRs), vertebrate receptors containing 17 leucine-rich repeats (LGR4-6), and the relaxin family peptide receptors (also known as LGR7 and LGR8). They are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone receptor family contains receptors for the pituitary hormones, thyrotropin (thyroid-stimulating hormone receptor), follitropin (follicle-stimulating hormone receptor), and lutropin (luteinizing hormone receptor). Glycoprotein hormone receptors couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein. Two orphan GPCRs, LGR7 and LGR8, have been recently identified as receptors for the relaxin peptide hormones.


Pssm-ID: 320111 [Multi-domain]  Cd Length: 286  Bit Score: 147.00  E-value: 4.03e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512151 447 WGIRLAVWAIVLLSVLCNGLVLLTVFAGGPAPLPPVKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLG 526
Cdd:cd14980     1 ISLRIFIWIIGILALIGNILVIIWHISSKKKKKKVPKLLIINLAIADFLMGIYLLIIAIADQYYRGRYAQYSEEWLRSPP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512151 527 CRATGFLAVLGSEASVLLLTLAAVQ----CSVSVSCVRAYGKSP--------SLGSVRAGVLGCLalaglaaalplaSVG 594
Cdd:cd14980    81 CLLACFLVSLSSLMSVLMMLLITLDryicIVYPFSNKRLSYKSAkiililgwLFSIIFAAIPILY------------SIN 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512151 595 E------YGASPLCLPYAPpeGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFEAV-----WDCAMVRHVAWL 663
Cdd:cd14980   149 QpgdnrlYGYSSICMPSNV--SNPYYRGWLIAYLLLTFIAWIIICILYILIFISVRKSRKSARrssskRDKRIAIRLALI 226

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462512151 664 IFADGLLYCPVAFLSFASMLGLFPVTPEAVKSVLLVVLPLPACLNPLLYLLFNPHF 719
Cdd:cd14980   227 LITDLICWLPYYIVIFSGLLTSTEIDIHVLQFIAILALPLNSAINPYLYTLTTPTF 282
7tmA_Glyco_hormone_R cd15136
glycoprotein hormone receptors, member of the class A family of seven-transmembrane G ...
 447-719 3.32e-36

glycoprotein hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors (GPHRs) are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG) and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. GPHRs couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein.


Pssm-ID: 320264 [Multi-domain]  Cd Length: 275  Bit Score: 138.12  E-value: 3.32e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512151 447 WGIRLAVWAIVLLSVLCNGLVLLtVFAGGPAPLPPVKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLG 526
Cdd:cd15136     1 WWLRIGVWFVFLLALVGNIIVLL-VLLTSRTKLTVPRFLMCNLAFADFCMGIYLGLLAIVDAKTLGEYYNYAIDWQTGAG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512151 527 CRATGFLAVLGSEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASVGEYGASPLCLPYA 606
Cdd:cd15136    80 CKTAGFLAVFSSELSVFTLTVITLERWYAITHAMHLNKRLSLRQAAIIMLGGWIFALIMALLPLVGVSSYSKTSICLPFE 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512151 607 ppEGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFEAVW-DCAMVRHVAWLIFADGLLYCPVAFLSFASMLGL 685
Cdd:cd15136   160 --TETPVSKAYVIFLLLFNGLAFLIICGCYIKIYLSVRGSGRAANSnDTRIAKRMALLVFTDFLCWAPIAFFGLTAAFGL 237

                         250       260       270
                  ....*....|....*....|....*....|....
gi 2462512151 686 FPVTPEAVKSVLLVVLPLPACLNPLLYLLFNPHF 719
Cdd:cd15136   238 PLISVSNAKILLVFFYPLNSCANPFLYAIFTKQF 271
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
33-342 6.20e-34

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 135.45  E-value: 6.20e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512151  33 NNLTELQPGLFHHLRFLEELRLSGNhlshipgQAFSGLYSLKILMLQNNQLGGIPAEaLWELPSLQSLRLDANLISLVPE 112
Cdd:COG4886    82 LSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDLPEE-LANLTNLKELDLSNNQLTDLPE 153

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512151 113 rSFEGLSSLRHLWLDDNALTEIPvRALNNLPALQAMTLALNRISHIPDyAFQNLTSLVVLDLNYNKLQEFPVAIRTLGRL 192
Cdd:COG4886   154 -PLGNLTNLKSLDLSNNQLTDLP-EELGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQLTDLPEPLANLTNL 230

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512151 193 QELGFHNNNIKAIPEKAfmgnpllqtihfydnpiqfvgrsafqylpklhtlslngamdiqefpdlkgttsleiltltrag 272
Cdd:COG4886   231 ETLDLSNNQLTDLPELG--------------------------------------------------------------- 247

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512151 273 irllpsgmcqQLPRLRVLELSHNQIEELPSLHRCQKLEEMDLTDNQLTTLPLAGLGGLMHLKLKGNLALS 342
Cdd:COG4886   248 ----------NLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLL 307
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
29-322 1.22e-32

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 131.59  E-value: 1.22e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512151  29 DLSMNNLTELqPGLFHHLRFLEELRLSGNHLSHIPgQAFSGLYSLKILMLQNNQLGGIPAEaLWELPSLQSLRLDANLIS 108
Cdd:COG4886   119 DLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLTDLPEE-LGNLTNLKELDLSNNQIT 195

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512151 109 LVPErSFEGLSSLRHLWLDDNALTEIPvRALNNLPALQAMTLALNRISHIPDyaFQNLTSLVVLDLNYNKLQEFPvAIRT 188
Cdd:COG4886   196 DLPE-PLGNLTNLEELDLSGNQLTDLP-EPLANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLP-PLAN 270

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512151 189 LGRLQELGFHNNNI-----KAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDLKGTTSL 263
Cdd:COG4886   271 LTNLKTLDLSNNQLtdlklKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALL 350

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462512151 264 EILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELPSLHRCQKLEEMDLTDNQLTTL 322
Cdd:COG4886   351 TLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLD 409
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
90-338 1.94e-32

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 130.82  E-value: 1.94e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512151  90 ALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNalteipvRALNNLPALQAMTLALNRISHIPDyAFQNLTSL 169
Cdd:COG4886    67 LLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDLPE-ELANLTNL 138

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512151 170 VVLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEkafmgnpllqtihfydnpiqfvgrsAFQYLPKLHTLSLNGAm 249
Cdd:COG4886   139 KELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPE-------------------------ELGNLTNLKELDLSNN- 192

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512151 250 DIQEFPD-LKGTTSLEILTLTRAGIRLLPSGMcQQLPRLRVLELSHNQIEELPSLHRCQKLEEMDLTDNQLTTLP-LAGL 327
Cdd:COG4886   193 QITDLPEpLGNLTNLEELDLSGNQLTDLPEPL-ANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPpLANL 271

                         250
                  ....*....|.
gi 2462512151 328 GGLMHLKLKGN 338
Cdd:COG4886   272 TNLKTLDLSNN 282
7tmA_TSH-R cd15964
thyroid-stimulating hormone receptor (or thyrotropin receptor), member of the class A family ...
 449-719 5.76e-26

thyroid-stimulating hormone receptor (or thyrotropin receptor), member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. TSH-R plays an important role thyroid physiology, and its activation stimulates the production of thyroxine (T4) and triiodothyronine (T3). Defects in TSH-R are a cause of several types of hyperthyroidism. The receptor is predominantly found on the surface of the thyroid epithelial cells and couples to the G(s)-protein and activates adenylate cyclase, thereby promoting cAMP production. TSH and cAMP stimulate thyroid cell proliferation, differentiation, and function.


Pssm-ID: 320630 [Multi-domain]  Cd Length: 275  Bit Score: 108.45  E-value: 5.76e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512151 449 IRLAVWAIVLLSVLCNGLVLLTVFAGGPAPLPPvKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLGCR 528
Cdd:cd15964     3 LRIVVWFVNLLAILGNVFVLLILLTSHYKLTVP-RFLMCNLAFADFCMGIYLLLIASVDLHTRSEYYNHAIDWQTGPGCN 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512151 529 ATGFLAVLGSEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASVGEYGASPLCLPYAPP 608
Cdd:cd15964    82 TAGFFTVFASELSVYTLTVITLERWYAITFAMRLDRKIRLRHASAIMLGGWVFCFLLALLPLVGVSSYAKVSICLPMDTE 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512151 609 egQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFEA-VWDCAMVRHVAWLIFADGLLYCPVAFLSFASMLGLFP 687
Cdd:cd15964   162 --TPLAQAYIVFVLMLNIIAFVIICACYIKIYITVRNPQYKSgDKDTKIAKRMAVLIFTDFICMAPISFYALSAILNKPL 239

                         250       260       270
                  ....*....|....*....|....*....|..
gi 2462512151 688 VTPEAVKSVLLVVLPLPACLNPLLYLLFNPHF 719
Cdd:cd15964   240 ITVSNSKILLVLFYPLNSCANPFLYAIFTKAF 271
7tmA_FSH-R cd15360
follicle-stimulating hormone receptor, member of the class A family of seven-transmembrane G ...
 449-719 6.07e-23

follicle-stimulating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. FSH-R functions in gonad development and is found in the ovary, testis, and uterus. Defects in this receptor cause ovarian dysgenesis type 1, and also ovarian hyperstimulation syndrome. The FSH-R activation couples to the G(s)-protein and stimulates adenylate cyclase, thereby promoting cAMP production.


Pssm-ID: 320482  Cd Length: 275  Bit Score: 99.55  E-value: 6.07e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512151 449 IRLAVWAIVLLSVLCNgLVLLTVFAGGPAPLPPVKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLGCR 528
Cdd:cd15360     3 LRVLIWFINILAITGN-IVVLAILLTSQYKLTVPRFLMCNLAFADLCMGIYLLLIASVDIRTKSQYYNYAIDWQTGAGCA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512151 529 ATGFLAVLGSEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASVGEYGASPLCLPYAPP 608
Cdd:cd15360    82 AAGFFTVFASELSVYTLTVITLERWHTITYAMQLDRKVRLRHAAVIMVGGWIFAFTVALLPIFGISSYMKVSICLPMDIE 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512151 609 egQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDF-EAVWDCAMVRHVAWLIFADGLLYCPVAFLSFASMLGLFP 687
Cdd:cd15360   162 --SPLSQAYIIFILVLNVLAFLIICACYIKIYLTVRNPNFvSSNSDTKIAKRMAVLIFTDFLCMAPISFFAISASLKVPL 239

                         250       260       270
                  ....*....|....*....|....*....|..
gi 2462512151 688 VTPEAVKSVLLVVLPLPACLNPLLYLLFNPHF 719
Cdd:cd15360   240 ITVSKSKILLVLFYPINSCANPFLYAIFTKTF 271
7tmA_LHCGR cd15359
luteinizing hormone-choriogonadotropin receptor, member of the class A family of ...
 449-719 2.49e-21

luteinizing hormone-choriogonadotropin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. LHCGR is expressed predominantly in the ovary and testis, and plays an essential role in sexual development and reproductive processes. LHCGR couples primarily to the G(s)-protein and activates adenylate cyclase, thereby promoting cAMP production.


Pssm-ID: 320481 [Multi-domain]  Cd Length: 275  Bit Score: 94.93  E-value: 2.49e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512151 449 IRLAVWAIVLLSVLCNGLVLLtVFAGGPAPLPPVKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLGCR 528
Cdd:cd15359     3 LRVLIWFINILAIAGNLIVLF-VLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDSQTKSQYYNHAIDWQTGSGCS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512151 529 ATGFLAVLGSEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASVGEYGASPLCLPYAPP 608
Cdd:cd15359    82 TAGFFTVFASELSVYTLTVITLERWHTITYAMQLDRKLRLRHAILIMLGGWVFSLLIAVLPLVGVSNYMKVSICLPMDIE 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512151 609 EGQPAAlgFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFEAV-WDCAMVRHVAWLIFADGLLYCPVAFLSFASMLGLFP 687
Cdd:cd15359   162 TLLSQA--YILLILVLNVIAFLVICACYIKIYLAVQNPELVAKnKDTKIAKRMAILIFTDFTCMAPISFFAISAAFKVPL 239

                         250       260       270
                  ....*....|....*....|....*....|..
gi 2462512151 688 VTPEAVKSVLLVVLPLPACLNPLLYLLFNPHF 719
Cdd:cd15359   240 ITVTNSKILLVLFYPINSCANPFLYAIFTKAF 271
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 29-338 6.76e-20

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 95.30  E-value: 6.76e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512151  29 DLSMNNLTELQP---GLFHHLRFLEelrLSGNHLS-HIPGqAFSGLYSLKILMLQNNQL-GGIPAEaLWELPSLQSLRLD 103
Cdd:PLN00113  146 DLSNNMLSGEIPndiGSFSSLKVLD---LGGNVLVgKIPN-SLTNLTSLEFLTLASNQLvGQIPRE-LGQMKSLKWIYLG 220

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512151 104 ANLISLVPERSFEGLSSLRHLWLDDNALT-EIPVrALNNLPALQAMTLALNRIS-HIPDYAFqNLTSLVVLDLNYNKLQ- 180
Cdd:PLN00113  221 YNNLSGEIPYEIGGLTSLNHLDLVYNNLTgPIPS-SLGNLKNLQYLFLYQNKLSgPIPPSIF-SLQKLISLDLSDNSLSg 298

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512151 181 EFPVAIRTLGRLQELG-FHNNNIKAIPEkAFMGNPLLQTIHFYDN------PIQFVGRSAFQYLpKLHTLSLNG------ 247
Cdd:PLN00113  299 EIPELVIQLQNLEILHlFSNNFTGKIPV-ALTSLPRLQVLQLWSNkfsgeiPKNLGKHNNLTVL-DLSTNNLTGeipegl 376

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512151 248 --------------AMDIQEFPDLKGTTSLEILTLTRAGIR-LLPSGMCQ-----------------------QLPRLRV 289
Cdd:PLN00113  377 cssgnlfklilfsnSLEGEIPKSLGACRSLRRVRLQDNSFSgELPSEFTKlplvyfldisnnnlqgrinsrkwDMPSLQM 456

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2462512151 290 LELSHNQIE-ELPSLHRCQKLEEMDLTDNQLT-TLP--LAGLGGLMHLKLKGN 338
Cdd:PLN00113  457 LSLARNKFFgGLPDSFGSKRLENLDLSRNQFSgAVPrkLGSLSELMQLKLSEN 509
7tmA_Relaxin_R cd15137
relaxin family peptide receptors, member of the class A family of seven-transmembrane G ...
 449-719 7.84e-19

relaxin family peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes relaxin/insulin-like family peptide receptor 1 (RXFP1 or LGR7) and 2 (RXFP2 or LGR8), which contain a very large extracellular N-terminal domain with numerous leucine-rich repeats responsible for hormone recognition and binding. Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural but low sequence similarity, and exert their physiological functions by activating a group of four GPCRs, RXFP1-4. Relaxin and INSL3 are the endogenous ligands for RXFP1 and RXFP2, respectively. Upon receptor binding, relaxin activates a variety of signaling pathways to produce second messengers such as cAMP.


Pssm-ID: 320265 [Multi-domain]  Cd Length: 284  Bit Score: 87.64  E-value: 7.84e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512151 449 IRLAVWAIVLLSVLCNGLVL---LTVFAGGPAPLppvkFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGL 525
Cdd:cd15137     3 LRVFIWVVGIIALLGNLFVLiwrLKYKEENKVHS----FLIKNLAIADFLMGVYLLIIASVDLYYRGVYIKHDEEWRSSW 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512151 526 GCRATGFLAVLGSEASVLLLTLAAVQ---CSVS-VSCVRAygKSPSLGSVRAGVLGCLALAGLAAALPLASVGE-YGASP 600
Cdd:cd15137    79 LCTFAGFLATLSSEVSVLILTLITLDrfiCIVFpFSGRRL--GLRRAIIVLACIWLIGLLLAVLPLLPWDYFGNfYGRSG 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512151 601 LCLPYAPPEGQPAALGFTVALVM-MNSFCFLVVAGAYIKLYCDLPR-----GDFEAVWDCAMVRHVAWLIFADGLLYCPV 674
Cdd:cd15137   157 VCLPLHITDERPAGWEYSVFVFLgLNFLAFVFILLSYIAMFISIRRtrkaaASRKSKRDMAVAKRFFLIVLTDFLCWIPI 236

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 2462512151 675 AFLSFASMLGlFPVTPEAVKSVLLVVLPLPACLNPLLYLLFNPHF 719
Cdd:cd15137   237 IVIGILALSG-VPIPGEVYAWVAVFVLPINSALNPILYTLSTPKF 280
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 29-338 7.73e-18

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 88.75  E-value: 7.73e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512151  29 DLSMNNLTELQPGLFHHLRFLEELRLSGNHLS-HIPGQAFSGLYSLKILMLQNNQL-GGIPAEAlweLPSLQSLRLDANL 106
Cdd:PLN00113   75 DLSGKNISGKISSAIFRLPYIQTINLSNNQLSgPIPDDIFTTSSSLRYLNLSNNNFtGSIPRGS---IPNLETLDLSNNM 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512151 107 ISLVPERSFEGLSSLRHLWLDDNALT-EIPVrALNNLPALQAMTLALNR-ISHIPDYAFQnLTSLVVLDLNYNKLQ-EFP 183
Cdd:PLN00113  152 LSGEIPNDIGSFSSLKVLDLGGNVLVgKIPN-SLTNLTSLEFLTLASNQlVGQIPRELGQ-MKSLKWIYLGYNNLSgEIP 229

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512151 184 VAIRTLGRLQELGF-HNNNIKAIPEKafMGN-PLLQTIHFYDNPIQ-FVGRSAFQyLPKLHTLSLNGAMDIQEFPDL-KG 259
Cdd:PLN00113  230 YEIGGLTSLNHLDLvYNNLTGPIPSS--LGNlKNLQYLFLYQNKLSgPIPPSIFS-LQKLISLDLSDNSLSGEIPELvIQ 306

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512151 260 TTSLEILTLTRAGIR-LLPSGMCqQLPRLRVLELSHNQIE-ELPS-LHRCQKLEEMDLTDNQLT-TLP--LAGLGGLMHL 333
Cdd:PLN00113  307 LQNLEILHLFSNNFTgKIPVALT-SLPRLQVLQLWSNKFSgEIPKnLGKHNNLTVLDLSTNNLTgEIPegLCSSGNLFKL 385


                  ....*
gi 2462512151 334 KLKGN 338
Cdd:PLN00113  386 ILFSN 390
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 30-206 3.21e-14

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 72.51  E-value: 3.21e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512151  30 LSMN--NLTELqpGLFHHLRFLEELRLSGNHLSHIPGqaFSGLYSLKILMLQNNQLGGIpaEALWELPSLQSLRLDANLI 107
Cdd:cd21340     7 LYLNdkNITKI--DNLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKI--ENLENLVNLKKLYLGGNRI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512151 108 SLVpErSFEGLSSLRHLWLDDNALTE-----IPVRALNNL-PALQAMTLALNRISHIPDyaFQNLTSLVVLDLNYNKLQE 181
Cdd:cd21340    81 SVV-E-GLENLTNLEELHIENQRLPPgekltFDPRSLAALsNSLRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQISD 156

                         170       180
                  ....*....|....*....|....*...
gi 2462512151 182 FP---VAIRTLGRLQELGFHNNNIKAIP 206
Cdd:cd21340   157 LEellDLLSSWPSLRELDLTGNPVCKKP 184
LRR_8 pfam13855
Leucine rich repeat;
49-107 1.29e-13

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 66.01  E-value: 1.29e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462512151  49 LEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLRLDANLI 107
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
119-179 7.63e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 58.30  E-value: 7.63e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462512151 119 SSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLDLNYNKL 179
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
7tmA_RXFP2_LGR8 cd15966
relaxin receptor 2 (or LGR8), member of the class A family of seven-transmembrane G ...
 492-719 1.11e-10

relaxin receptor 2 (or LGR8), member of the class A family of seven-transmembrane G protein-coupled receptors; Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural similarity, but low sequence similarity, and exert their physiological functions by activating a group of four G protein-coupled receptors, RXFP1-4. INSL3 is the endogenous ligand for RXFP2, which couples to the G(s) protein to increase intracellular cAMP levels, but also to the GoB protein to decrease cAMP formation. RXFP2 (or LGR8) is expressed in various tissues including the brain, kidney, muscle, testis, thyroid, uterus, and peripheral blood cells, among others.


Pssm-ID: 320632  Cd Length: 287  Bit Score: 63.27  E-value: 1.11e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512151 492 ANTLTGISCGLLASVDALTFGQFSEYGARWETGLGCRATGFLAVLGSEASVLLLTLAAVQCSVSV----SCVRAyGKSPS 567
Cdd:cd15966    45 ADCLMGVYLFFVGIFDVKYRGEYNKYALLWMESLQCRIIGFLAMLSTEVSVLLLTYLTLEKYLVIvfpfSNIRP-GKCQT 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512151 568 LgSVRAGVLGCLALAGLAAALPLASVGE-YGASPLCLP-YAPPEGQPAALGFTVALVM-MNSFCFLVVAGAYIKLYCDLP 644
Cdd:cd15966   124 L-IILISIWLVGFIIAVIPFWNEDFFGNyYGKNGVCFPlHSDQTEKIGAKGYSTGIFLgLNLLAFIIIVFSYSSMFCSIQ 202

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512151 645 RGDFEAV-------WDCAMVRHVAWLIFADGLLYCPVAFLsfaSMLGLFPV-TPEAVKS-VLLVVLPLPACLNPLLYLLF 715
Cdd:cd15966   203 KTGLQTTevrshihRDVAVANRFFFIVFSDAICWIPIFLL---KILSLFQVeIPGTITSwIVIFILPINSALNPILYTLT 279


                  ....
gi 2462512151 716 NPHF 719
Cdd:cd15966   280 TSFF 283
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 29-320 1.85e-10

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 64.87  E-value: 1.85e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512151  29 DLSMNNLTELQPGLFHHLRFLEELRLSGNHLS-HIPGqAFSGLYSLKILMLQNNQL-GGIPAEaLWELPSLQSLRLDAN- 105
Cdd:PLN00113  290 DLSDNSLSGEIPELVIQLQNLEILHLFSNNFTgKIPV-ALTSLPRLQVLQLWSNKFsGEIPKN-LGKHNNLTVLDLSTNn 367

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512151 106 LISLVPersfEGLSSLRHLW---LDDNAL-TEIPvRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLDLNYNKLQe 181
Cdd:PLN00113  368 LTGEIP----EGLCSSGNLFkliLFSNSLeGEIP-KSLGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQ- 441

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512151 182 fpvairtlGRLQELGFHnnnikaipekafmgnpllqtihfydnpiqfvgrsafqyLPKLHTLSLNGAMDIQEFPDLKGTT 261
Cdd:PLN00113  442 --------GRINSRKWD--------------------------------------MPSLQMLSLARNKFFGGLPDSFGSK 475

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462512151 262 SLEILTLTRAGIR-LLPSGMcQQLPRLRVLELSHNQIE-ELPS-LHRCQKLEEMDLTDNQLT 320
Cdd:PLN00113  476 RLENLDLSRNQFSgAVPRKL-GSLSELMQLKLSENKLSgEIPDeLSSCKKLVSLDLSHNQLS 536
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
28-323 1.92e-10

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 64.72  E-value: 1.92e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512151  28 RDLSMNNLTELQpglfhhlrfLEELRLSgNHLSHIPGQafsglysLKILMLQNNQLGGIPaEALWelPSLQSLRLDANLI 107
Cdd:PRK15370  173 RDCLKNNKTELR---------LKILGLT-TIPACIPEQ-------ITTLILDNNELKSLP-ENLQ--GNIKTLYANSNQL 232

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512151 108 SLVPERSFEglsSLRHLWLDDNALTEIPVRalnnLP-ALQAMTLALNRISHIPDYAFQNLTSLVVLDLNYNKLQE-FPVA 185
Cdd:PRK15370  233 TSIPATLPD---TIQEMELSINRITELPER----LPsALQSLDLFHNKISCLPENLPEELRYLSVYDNSIRTLPAhLPSG 305

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512151 186 IrtlgrlQELGFHNNNIKAIPEKAFMGnplLQTIHFYDNPIQFVGRSafqyLPklhtlslngamdiqefPDLKgttsleI 265
Cdd:PRK15370  306 I------THLNVQSNSLTALPETLPPG---LKTLEAGENALTSLPAS----LP----------------PELQ------V 350

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2462512151 266 LTLTRAGIRLLPSGMCqqlPRLRVLELSHNQIEELPSlHRCQKLEEMDLTDNQLTTLP 323
Cdd:PRK15370  351 LDVSKNQITVLPETLP---PTITTLDVSRNALTNLPE-NLPAALQIMQASRNNLVRLP 404
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 118-338 4.59e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 60.57  E-value: 4.59e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512151 118 LSSLRHLWLDDNALTEIPvrALNNLPALQAMTLALNRISHIPDyaFQNLTSLVVLDLNYNKLQEfpvaIRTLGRLQELgf 197
Cdd:cd21340     1 LKRITHLYLNDKNITKID--NLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEK----IENLENLVNL-- 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512151 198 hnnnikaipEKAFMGNpllqtihfydNPIQFVgrSAFQYLPKLHTLSLNGamdiQefpDLKGTTSLEILTLTRAGIRllp 277
Cdd:cd21340    71 ---------KKLYLGG----------NRISVV--EGLENLTNLEELHIEN----Q---RLPPGEKLTFDPRSLAALS--- 119

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462512151 278 sgmcqqlPRLRVLELSHNQIEELPSLHRCQKLEEMDLTDNQLT-----TLPLAGLGGLMHLKLKGN 338
Cdd:cd21340   120 -------NSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISdleelLDLLSSWPSLRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
29-83 1.10e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 54.84  E-value: 1.10e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2462512151  29 DLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQL 83
Cdd:pfam13855   7 DLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 47-184 1.37e-09

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 61.79  E-value: 1.37e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512151  47 RFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLRLDANLISLVPERSFeGLSSLRHLWL 126
Cdd:PLN00113  404 RSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLARNKFFGGLPDSF-GSKRLENLDL 482

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462512151 127 DDNALTEIPVRALNNLPALQAMTLALNRIS-HIPDyAFQNLTSLVVLDLNYNKLQ--------EFPV 184
Cdd:PLN00113  483 SRNQFSGAVPRKLGSLSELMQLKLSENKLSgEIPD-ELSSCKKLVSLDLSHNQLSgqipasfsEMPV 548
LRR_8 pfam13855
Leucine rich repeat;
143-202 1.24e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 51.76  E-value: 1.24e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462512151 143 PALQAMTLALNRISHIPDYAFQNLTSLVVLDLNYNKLQEF-PVAIRTLGRLQELGFHNNNI 202
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 88-321 2.01e-08

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 56.98  E-value: 2.01e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512151  88 AEALWELPSLQSLRLDANLISlvpERSFEGLS-------SLRHLWLDDNALTEIPV------RALNNLPALQAMTLALNR 154
Cdd:cd00116    16 TELLPKLLCLQVLRLEGNTLG---EEAAKALAsalrpqpSLKELCLSLNETGRIPRglqsllQGLTKGCGLQELDLSDNA 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512151 155 IShiPD-----YAFQNLTSLVVLDLNYNKLQEFPVAI--RTLG----RLQELGFHNNNIKAIP----EKAFMGNPLLQTI 219
Cdd:cd00116    93 LG--PDgcgvlESLLRSSSLQELKLNNNGLGDRGLRLlaKGLKdlppALEKLVLGRNRLEGAScealAKALRANRDLKEL 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512151 220 HFYDNPIQFVG-RSAFQYLP---KLHTLSLN-------GAMDIQE-FPDLKgttSLEILTL-----TRAGIRLLPSGMCQ 282
Cdd:cd00116   171 NLANNGIGDAGiRALAEGLKancNLEVLDLNnngltdeGASALAEtLASLK---SLEVLNLgdnnlTDAGAAALASALLS 247

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 2462512151 283 QLPRLRVLELSHNQIEELPSLHRCQ------KLEEMDLTDNQLTT 321
Cdd:cd00116   248 PNISLLTLSLSCNDITDDGAKDLAEvlaekeSLLELDLRGNKFGE 292
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 96-240 1.57e-07

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 51.01  E-value: 1.57e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512151  96 SLQSLRLDANLISlVPERSFEGLSSLRHLWLDDNaLTEIPVRALNNLPaLQAMTLAlNRISHIPDYAFQNLTSLVVLDLn 175
Cdd:pfam13306  12 SLTSITIPSSLTS-IGEYAFSNCTSLKSITLPSS-LTSIGSYAFYNCS-LTSITIP-SSLTSIGEYAFSNCSNLKSITL- 86

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462512151 176 ynklqefpvairtlgrlqelgfhNNNIKAIPEKAFMGNPlLQTIHFYDNpIQFVGRSAFQYLPKL 240
Cdd:pfam13306  87 -----------------------PSNLTSIGSYAFSNCS-LKSITIPSS-VTTIGSYAFSNCSNL 126
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 29-181 6.02e-07

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 52.36  E-value: 6.02e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512151  29 DLSMNNLT----ELQPGLFHHLRFLEELRLSGNHLSH--IP--GQAFSGLYSLKILMLQNNQL----GGIPAEALWELPS 96
Cdd:cd00116   143 VLGRNRLEgascEALAKALRANRDLKELNLANNGIGDagIRalAEGLKANCNLEVLDLNNNGLtdegASALAETLASLKS 222

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512151  97 LQSLRLDANLISLVPERSF-----EGLSSLRHLWLDDNALTEIPVRALnnLPALQAMtlalnrishipdyafqnlTSLVV 171
Cdd:cd00116   223 LEVLNLGDNNLTDAGAAALasallSPNISLLTLSLSCNDITDDGAKDL--AEVLAEK------------------ESLLE 282

                         170
                  ....*....|
gi 2462512151 172 LDLNYNKLQE 181
Cdd:cd00116   283 LDLRGNKFGE 292
7tmA_RXFP1_LGR7 cd15965
relaxin receptor 1 (or LGR7), member of the class A family of seven-transmembrane G ...
 492-714 6.33e-07

relaxin receptor 1 (or LGR7), member of the class A family of seven-transmembrane G protein-coupled receptors; Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural but low sequence similarity, and exert their physiological functions by activating a group of four G protein-coupled receptors, RXFP1-4. Relaxin is the endogenous ligand for RXFP1, which has a large extracellular N-terminal domain containing 10 leucine-rich repeats and a unique low-density lipoprotein type A (LDLa) module which is necessary for receptor activation. Upon receptor binding, relaxin activates a variety of signaling pathways to produce second messengers such as cAMP and nitric oxide. RXFP1 is expressed in various tissues including uterus, ovary, placenta, cerebral cortex, heart, lung and kidney, among others.


Pssm-ID: 320631 [Multi-domain]  Cd Length: 287  Bit Score: 51.79  E-value: 6.33e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512151 492 ANTLTGISCGLLASVDALTFGQFSEYGARWETGLGCRATGFLAVLGSEASVLLLTLAAVQ---CSV-SVSCVRAyGKSPS 567
Cdd:cd15965    45 ADCLMGIYLFVIGAFDLKYRGEYNKHAQLWMDSTQCQLVGSLAILSTEVSVLLLTYLTLEkyiCIVyPFRCLTP-GKCRT 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512151 568 LGSVRAGVLGCLALAGLAAALPLASVGEYGASPLCLPY--APPEGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPR 645
Cdd:cd15965   124 ITILILIWIIGFIIAFIPLSNKEFFRNYYGTNGVCFPLhsEQPESTGAQIYSVVIFLGLNLAAFIIIVFSYGSMFYSIHQ 203

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462512151 646 GDFEAVW-------DCAMVRHVAWLIFADGLLYCPVAFLSFASMLGLfpVTPEAVKS-VLLVVLPLPACLNPLLYLL 714
Cdd:cd15965   204 TAIMATEisnhikkEMTLAKRFFFIVFTDALCWIPIFILKLLSLLQV--EIPGTISSwVVIFILPINSALNPILYTL 278
LRR_8 pfam13855
Leucine rich repeat;
191-247 1.09e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 46.36  E-value: 1.09e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462512151 191 RLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNG 247
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSG 58
LRR_8 pfam13855
Leucine rich repeat;
285-339 6.36e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.44  E-value: 6.36e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512151 285 PRLRVLELSHNQIEELP--SLHRCQKLEEMDLTDNQLTTLP---LAGLGGLMHLKLKGNL 339
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDdgAFKGLSNLKVLDLSNNLLTTLSpgaFSGLPSLRYLDLSGNR 60
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 29-288 7.83e-06

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 49.40  E-value: 7.83e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512151  29 DLSMNNLTELQPGLFHHLRFLEEL-------------RLSGNHLSHIPGQAFSGLY-----SLKILMLQNNQLGGIPAEA 90
Cdd:COG5238   120 RRIMAKTLEDSLILYLALPRRINLiqvlkdplggnavHLLGLAARLGLLAAISMAKalqnnSVETVYLGCNQIGDEGIEE 199

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512151  91 LWEL----PSLQSLRLDANLISLVPERSF----EGLSSLRHLWLDDNALTEIPVRALNNlpALQAMT------LALNRIS 156
Cdd:COG5238   200 LAEAltqnTTVTTLWLKRNPIGDEGAEILaealKGNKSLTTLDLSNNQIGDEGVIALAE--ALKNNTtvetlyLSGNQIG 277

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512151 157 H----IPDYAFQNLTSLVVLDLNYNKLQEFPV-----AIRTLGRLQELGFHNNNI-----KAIPeKAFMGNPLLQTIHFY 222
Cdd:COG5238   278 AegaiALAKALQGNTTLTSLDLSVNRIGDEGAialaeGLQGNKTLHTLNLAYNGIgaqgaIALA-KALQENTTLHSLDLS 356

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462512151 223 DNPIQFVGRSAF-QYL---PKLHTLSLnGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSG------MCQQLPRLR 288
Cdd:COG5238   357 DNQIGDEGAIALaKYLegnTTLRELNL-GKNNIGKQGAEALIDALQTNRLHTLILDGNLIGaeaqqrLEQLLERIK 431
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 49-169 2.30e-05

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 44.46  E-value: 2.30e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512151  49 LEELRLSgNHLSHIPGQAFSGLYSLKILMLQNNqLGGIPAEALWELpSLQSLRLDANLISLvPERSFEGLSSLRHLWLDD 128
Cdd:pfam13306  13 LTSITIP-SSLTSIGEYAFSNCTSLKSITLPSS-LTSIGSYAFYNC-SLTSITIPSSLTSI-GEYAFSNCSNLKSITLPS 88

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2462512151 129 NaLTEIPVRALNNLPaLQAMTLALNrISHIPDYAFQNLTSL 169
Cdd:pfam13306  89 N-LTSIGSYAFSNCS-LKSITIPSS-VTTIGSYAFSNCSNL 126
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
125-366 2.47e-05

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 48.15  E-value: 2.47e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512151 125 WLDDNALTEIPvralNNLPALQAM---------TLALNRI--SHIPDYAFQNLTSLVvldLNYNKLQEFPVAIRtlGRLQ 193
Cdd:PRK15370  153 WVKEAPAKEAA----NREEAVQRMrdclknnktELRLKILglTTIPACIPEQITTLI---LDNNELKSLPENLQ--GNIK 223

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512151 194 ELGFHNNNIKAIPEkafmgnpllqtihfydnpiqfvgrsafqylpklhTLslngamdiqefPDlkgttSLEILTLTRAGI 273
Cdd:PRK15370  224 TLYANSNQLTSIPA----------------------------------TL-----------PD-----TIQEMELSINRI 253

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512151 274 RLLPsgmcQQLPR-LRVLELSHNQIEELPSlHRCQKLEEMDLTDNQLTTLPLAGLGGLMHLKLKGNlalSQAFSKDSFP- 351
Cdd:PRK15370  254 TELP----ERLPSaLQSLDLFHNKISCLPE-NLPEELRYLSVYDNSIRTLPAHLPSGITHLNVQSN---SLTALPETLPp 325

                         250
                  ....*....|....*.
gi 2462512151 352 KLRILEV-PYAYQCCP 366
Cdd:PRK15370  326 GLKTLEAgENALTSLP 341
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 285-323 2.60e-05

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 41.85  E-value: 2.60e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 2462512151 285 PRLRVLELSHNQIEELPSLHRCQKLEEMDLTDN-QLTTLP 323
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSGNnKITDLS 40
LRR_8 pfam13855
Leucine rich repeat;
261-319 4.76e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.74  E-value: 4.76e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462512151 261 TSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELP--SLHRCQKLEEMDLTDNQL 319
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSpgAFSGLPSLRYLDLSGNRL 61
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
 455-716 2.71e-04

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 43.82  E-value: 2.71e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512151 455 AIVLLSVLCNGLVLLTVFAGgPAPLPPVKFVVGAIAGANTLTGISCGLLASVDALTFGQfseygarWETGLGCRATGFLA 534
Cdd:cd00637     7 LIFVVGLVGNLLVILVILRN-RRLRTVTNYFILNLAVADLLVGLLVIPFSLVSLLLGRW-------WFGDALCKLLGFLQ 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512151 535 VLGSEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASVGEYGASPLCLPYAPPEGQPAA 614
Cdd:cd00637    79 SVSLLASILTLTAISVDRYLAIVHPLRYRRRFTRRRAKLLIALIWLLSLLLALPPLLGWGVYDYGGYCCCCLCWPDLTLS 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512151 615 LGFTVALVMMNSF-CFLVVAGAYIKLYCDL-------------PRGDFEAVWDCAMVRHVAWLIFADGLLYCPVAFLSFA 680
Cdd:cd00637   159 KAYTIFLFVLLFLlPLLVIIVCYVRIFRKLrrhrrrirssssnSSRRRRRRRERKVTKTLLIVVVVFLLCWLPYFILLLL 238

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 2462512151 681 SMLGLFPV-TPEAVKSVLLVVLPLPACLNPLLYLLFN 716
Cdd:cd00637   239 DVFGPDPSpLPRILYFLALLLAYLNSAINPIIYAFFN 275
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 49-204 1.05e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 41.96  E-value: 1.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512151  49 LEELRLSGNHLS-HIPG--QAFSGLYSLKILMLQNNQLGG----IPAEALWEL-PSLQSLRLDANLISLVPERS----FE 116
Cdd:cd00116    83 LQELDLSDNALGpDGCGvlESLLRSSSLQELKLNNNGLGDrglrLLAKGLKDLpPALEKLVLGRNRLEGASCEAlakaLR 162

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512151 117 GLSSLRHLWLDDNALTE--IPV--RALNNLPALQAMTLALNRISHIPDYA----FQNLTSLVVLDLNYNKLQEFPVA--- 185
Cdd:cd00116   163 ANRDLKELNLANNGIGDagIRAlaEGLKANCNLEVLDLNNNGLTDEGASAlaetLASLKSLEVLNLGDNNLTDAGAAala 242

                         170       180
                  ....*....|....*....|..
gi 2462512151 186 ---IRTLGRLQELGFHNNNIKA 204
Cdd:cd00116   243 salLSPNISLLTLSLSCNDITD 264
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
139-323 1.16e-03

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 42.46  E-value: 1.16e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512151 139 LNNLPALqaMTLALNRISHIPDYAFQNLTSLVVLDLNYNKLQEFPVAIRTlgrlqeLGFHNNNIKAIPekafMGNPLLQT 218
Cdd:PRK15387  199 LNNGNAV--LNVGESGLTTLPDCLPAHITTLVIPDNNLTSLPALPPELRT------LEVSGNQLTSLP----VLPPGLLE 266

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512151 219 IHFYDNPIqfvgrsafQYLPKLHT----LSLNGAmDIQEFPDL-KGTTSLEILTLTRAGIRLLPSGMCQqlprlrvLELS 293
Cdd:PRK15387  267 LSIFSNPL--------THLPALPSglckLWIFGN-QLTSLPVLpPGLQELSVSDNQLASLPALPSELCK-------LWAY 330

                         170       180       190
                  ....*....|....*....|....*....|
gi 2462512151 294 HNQIEELPSLHrcQKLEEMDLTDNQLTTLP 323
Cdd:PRK15387  331 NNQLTSLPTLP--SGLQELSVSDNQLASLP 358
PLN03150 PLN03150
hypothetical protein; Provisional
 142-225 1.63e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 42.11  E-value: 1.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512151 142 LPALQAMTLALNRISHIPDYAFQNLTSLVVLDLNYNKLQ-EFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTI- 219
Cdd:PLN03150  441 LRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSLSGRVPAALGGRLLHRASf 520


                  ....*.
gi 2462512151 220 HFYDNP 225
Cdd:PLN03150  521 NFTDNA 526
LRR_8 pfam13855
Leucine rich repeat;
214-297 2.71e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 36.73  E-value: 2.71e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512151 214 PLLQTIHFYDNPIQFVGRSAFQYLPklhtlslngamdiqefpdlkgttSLEILTLTRAGIRLLPSGMCQQLPRLRVLELS 293
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLS-----------------------NLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLS 57


                  ....
gi 2462512151 294 HNQI 297
Cdd:pfam13855  58 GNRL 61
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 158-234 8.21e-03

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 37.14  E-value: 8.21e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462512151 158 IPDYAFQN--LTSLVvldlnynklqeFPvairtlgrlqelgfhnNNIKAIPEKAFMGNPLLQTIHFYDNpIQFVGRSAF 234
Cdd:pfam13306   3 IGSYAFYNcsLTSIT-----------IP----------------SSLTSIGEYAFSNCTSLKSITLPSS-LTSIGSYAF 53
PLN03150 PLN03150
hypothetical protein; Provisional
 30-108 8.71e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 39.80  E-value: 8.71e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512151  30 LSMNN--LTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLRLDANLI 107
Cdd:PLN03150  423 LGLDNqgLRGFIPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSL 502


                  .
gi 2462512151 108 S 108
Cdd:PLN03150  503 S 503
LRR smart00370
Leucine-rich repeats, outliers;
46-69 9.48e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 34.25  E-value: 9.48e-03
                           10        20
                   ....*....|....*....|....
gi 2462512151   46 LRFLEELRLSGNHLSHIPGQAFSG 69
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
46-69 9.48e-03

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 34.25  E-value: 9.48e-03
                           10        20
                   ....*....|....*....|....
gi 2462512151   46 LRFLEELRLSGNHLSHIPGQAFSG 69
Cdd:smart00369   1 LPNLRELDLSNNQLSSLPPGAFQG 24
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH