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Conserved domains on  [gi|2462513322|ref|XP_054194574|]
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putative neuroblastoma breakpoint family member 8 isoform X2 [Homo sapiens]

Protein Classification

NBPF family protein( domain architecture ID 10535968)

neuroblastoma breakpoint family (NBPF) protein is a DUF1220 domain-containing protein

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
Olduvai pfam06758
Olduvai domain; This domain formerly known as DUF1220 or NBPF domain has been renamed as the ...
321-380 1.66e-12

Olduvai domain; This domain formerly known as DUF1220 or NBPF domain has been renamed as the Olduvai domain. It is found highly duplicated in the human lineage.


:

Pssm-ID: 429104 [Multi-domain]  Cd Length: 68  Bit Score: 63.21  E-value: 1.66e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462513322 321 KVQKSSAP---REVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNIKITFEEDEVNSTL 380
Cdd:pfam06758   6 EDQEPLAPrlsRELPEVEEQEVPQDSLDECYLTPSVLPDLSDSYQPYRSTIFSFEEQQVSSAL 68
Olduvai pfam06758
Olduvai domain; This domain formerly known as DUF1220 or NBPF domain has been renamed as the ...
592-651 6.98e-12

Olduvai domain; This domain formerly known as DUF1220 or NBPF domain has been renamed as the Olduvai domain. It is found highly duplicated in the human lineage.


:

Pssm-ID: 429104 [Multi-domain]  Cd Length: 68  Bit Score: 61.28  E-value: 6.98e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462513322 592 KVQKSSAP---REVQKAEESKVPEDSLEECAITCSNSHGPCDFNQPHKNIKITFEEDEVNSTL 651
Cdd:pfam06758   6 EDQEPLAPrlsRELPEVEEQEVPQDSLDECYLTPSVLPDLSDSYQPYRSTIFSFEEQQVSSAL 68
PTZ00121 super family cl31754
MAEBL; Provisional
177-613 5.18e-03

MAEBL; Provisional


The actual alignment was detected with superfamily member PTZ00121:

Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 40.89  E-value: 5.18e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462513322  177 NLKERCFLTQLAGFLANRQKKYKYEECKDLIRFmlrneRQFKEEKLAEQLKQAEELRQYKVLVHSQE--RELTQLKEKLQ 254
Cdd:PTZ00121  1251 NEEIRKFEEARMAHFARRQAAIKAEEARKADEL-----KKAEEKKKADEAKKAEEKKKADEAKKKAEeaKKADEAKKKAE 1325
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462513322  255 EGRDASRSLNEHLQALLTLDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEDEKVQ--KSSAPREVQ 332
Cdd:PTZ00121  1326 EAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADeaKKKAEEDKK 1405
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462513322  333 KAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNIKITFEEDEVnstlvvdrESSHDECQDALNILSVPGPTSSATNVSm 412
Cdd:PTZ00121  1406 KADELKKAAAAKKKADEAKKKAEEKKKADEAKKKAEEAKKADEA--------KKKAEEAKKAEEAKKKAEEAKKADEAK- 1476
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462513322  413 vvsagplssEKAEMNilEINEKLHPQLAEKKQQFVNLKEKCFLTQLAGFLANRQKKYKYEECkdlirfmlrneRQFKEEK 492
Cdd:PTZ00121  1477 ---------KKAEEA--KKADEAKKKAEEAKKKADEAKKAAEAKKKADEAKKAEEAKKADEA-----------KKAEEAK 1534
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462513322  493 LAEQLKQAEELRQYKVLVHSQERELTQLKEKLQEGRDASRSLNEHLQALLTLDEPDKSQGQDLQEQLAEGCRLAQHLVQK 572
Cdd:PTZ00121  1535 KADEAKKAEEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKK 1614
                          410       420       430       440
                   ....*....|....*....|....*....|....*....|...
gi 2462513322  573 LSPENDEDEDEDVQVEEDEKVQ--KSSAPREVQKAEESKVPED 613
Cdd:PTZ00121  1615 AEEAKIKAEELKKAEEEKKKVEqlKKKEAEEKKKAEELKKAEE 1657
 
Name Accession Description Interval E-value
Olduvai pfam06758
Olduvai domain; This domain formerly known as DUF1220 or NBPF domain has been renamed as the ...
321-380 1.66e-12

Olduvai domain; This domain formerly known as DUF1220 or NBPF domain has been renamed as the Olduvai domain. It is found highly duplicated in the human lineage.


Pssm-ID: 429104 [Multi-domain]  Cd Length: 68  Bit Score: 63.21  E-value: 1.66e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462513322 321 KVQKSSAP---REVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNIKITFEEDEVNSTL 380
Cdd:pfam06758   6 EDQEPLAPrlsRELPEVEEQEVPQDSLDECYLTPSVLPDLSDSYQPYRSTIFSFEEQQVSSAL 68
Olduvai pfam06758
Olduvai domain; This domain formerly known as DUF1220 or NBPF domain has been renamed as the ...
592-651 6.98e-12

Olduvai domain; This domain formerly known as DUF1220 or NBPF domain has been renamed as the Olduvai domain. It is found highly duplicated in the human lineage.


Pssm-ID: 429104 [Multi-domain]  Cd Length: 68  Bit Score: 61.28  E-value: 6.98e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462513322 592 KVQKSSAP---REVQKAEESKVPEDSLEECAITCSNSHGPCDFNQPHKNIKITFEEDEVNSTL 651
Cdd:pfam06758   6 EDQEPLAPrlsRELPEVEEQEVPQDSLDECYLTPSVLPDLSDSYQPYRSTIFSFEEQQVSSAL 68
PTZ00121 PTZ00121
MAEBL; Provisional
177-613 5.18e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 40.89  E-value: 5.18e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462513322  177 NLKERCFLTQLAGFLANRQKKYKYEECKDLIRFmlrneRQFKEEKLAEQLKQAEELRQYKVLVHSQE--RELTQLKEKLQ 254
Cdd:PTZ00121  1251 NEEIRKFEEARMAHFARRQAAIKAEEARKADEL-----KKAEEKKKADEAKKAEEKKKADEAKKKAEeaKKADEAKKKAE 1325
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462513322  255 EGRDASRSLNEHLQALLTLDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEDEKVQ--KSSAPREVQ 332
Cdd:PTZ00121  1326 EAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADeaKKKAEEDKK 1405
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462513322  333 KAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNIKITFEEDEVnstlvvdrESSHDECQDALNILSVPGPTSSATNVSm 412
Cdd:PTZ00121  1406 KADELKKAAAAKKKADEAKKKAEEKKKADEAKKKAEEAKKADEA--------KKKAEEAKKAEEAKKKAEEAKKADEAK- 1476
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462513322  413 vvsagplssEKAEMNilEINEKLHPQLAEKKQQFVNLKEKCFLTQLAGFLANRQKKYKYEECkdlirfmlrneRQFKEEK 492
Cdd:PTZ00121  1477 ---------KKAEEA--KKADEAKKKAEEAKKKADEAKKAAEAKKKADEAKKAEEAKKADEA-----------KKAEEAK 1534
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462513322  493 LAEQLKQAEELRQYKVLVHSQERELTQLKEKLQEGRDASRSLNEHLQALLTLDEPDKSQGQDLQEQLAEGCRLAQHLVQK 572
Cdd:PTZ00121  1535 KADEAKKAEEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKK 1614
                          410       420       430       440
                   ....*....|....*....|....*....|....*....|...
gi 2462513322  573 LSPENDEDEDEDVQVEEDEKVQ--KSSAPREVQKAEESKVPED 613
Cdd:PTZ00121  1615 AEEAKIKAEELKKAEEEKKKVEqlKKKEAEEKKKAEELKKAEE 1657
 
Name Accession Description Interval E-value
Olduvai pfam06758
Olduvai domain; This domain formerly known as DUF1220 or NBPF domain has been renamed as the ...
321-380 1.66e-12

Olduvai domain; This domain formerly known as DUF1220 or NBPF domain has been renamed as the Olduvai domain. It is found highly duplicated in the human lineage.


Pssm-ID: 429104 [Multi-domain]  Cd Length: 68  Bit Score: 63.21  E-value: 1.66e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462513322 321 KVQKSSAP---REVQKAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNIKITFEEDEVNSTL 380
Cdd:pfam06758   6 EDQEPLAPrlsRELPEVEEQEVPQDSLDECYLTPSVLPDLSDSYQPYRSTIFSFEEQQVSSAL 68
Olduvai pfam06758
Olduvai domain; This domain formerly known as DUF1220 or NBPF domain has been renamed as the ...
592-651 6.98e-12

Olduvai domain; This domain formerly known as DUF1220 or NBPF domain has been renamed as the Olduvai domain. It is found highly duplicated in the human lineage.


Pssm-ID: 429104 [Multi-domain]  Cd Length: 68  Bit Score: 61.28  E-value: 6.98e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462513322 592 KVQKSSAP---REVQKAEESKVPEDSLEECAITCSNSHGPCDFNQPHKNIKITFEEDEVNSTL 651
Cdd:pfam06758   6 EDQEPLAPrlsRELPEVEEQEVPQDSLDECYLTPSVLPDLSDSYQPYRSTIFSFEEQQVSSAL 68
PTZ00121 PTZ00121
MAEBL; Provisional
177-613 5.18e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 40.89  E-value: 5.18e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462513322  177 NLKERCFLTQLAGFLANRQKKYKYEECKDLIRFmlrneRQFKEEKLAEQLKQAEELRQYKVLVHSQE--RELTQLKEKLQ 254
Cdd:PTZ00121  1251 NEEIRKFEEARMAHFARRQAAIKAEEARKADEL-----KKAEEKKKADEAKKAEEKKKADEAKKKAEeaKKADEAKKKAE 1325
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462513322  255 EGRDASRSLNEHLQALLTLDEPDKSQGQDLQEQLAEGCRLAQHLVQKLSPENDEDEDEDVQVEEDEKVQ--KSSAPREVQ 332
Cdd:PTZ00121  1326 EAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADeaKKKAEEDKK 1405
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462513322  333 KAEESKVPEDSLEECAITCSNSHGPCDSNQPHKNIKITFEEDEVnstlvvdrESSHDECQDALNILSVPGPTSSATNVSm 412
Cdd:PTZ00121  1406 KADELKKAAAAKKKADEAKKKAEEKKKADEAKKKAEEAKKADEA--------KKKAEEAKKAEEAKKKAEEAKKADEAK- 1476
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462513322  413 vvsagplssEKAEMNilEINEKLHPQLAEKKQQFVNLKEKCFLTQLAGFLANRQKKYKYEECkdlirfmlrneRQFKEEK 492
Cdd:PTZ00121  1477 ---------KKAEEA--KKADEAKKKAEEAKKKADEAKKAAEAKKKADEAKKAEEAKKADEA-----------KKAEEAK 1534
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462513322  493 LAEQLKQAEELRQYKVLVHSQERELTQLKEKLQEGRDASRSLNEHLQALLTLDEPDKSQGQDLQEQLAEGCRLAQHLVQK 572
Cdd:PTZ00121  1535 KADEAKKAEEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKK 1614
                          410       420       430       440
                   ....*....|....*....|....*....|....*....|...
gi 2462513322  573 LSPENDEDEDEDVQVEEDEKVQ--KSSAPREVQKAEESKVPED 613
Cdd:PTZ00121  1615 AEEAKIKAEELKKAEEEKKKVEqlKKKEAEEKKKAEELKKAEE 1657
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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