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Conserved domains on  [gi|2462513706|ref|XP_054194763|]
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zinc finger MYM-type protein 1 isoform X4 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF4371 super family cl46273
Domain of unknown function (DUF4371);
419-652 3.64e-29

Domain of unknown function (DUF4371);


The actual alignment was detected with superfamily member pfam14291:

Pssm-ID: 480613  Cd Length: 236  Bit Score: 116.95  E-value: 3.64e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462513706  419 SFATHGTSNWKK--TLEKFRKHEKSEMH----LKSLEFWREYQFCDGAVsddlsIHSKQIEGNKK--YLKLIIENILFLG 490
Cdd:pfam14291    2 AFLSTGFCSWNKadRLDQFVGHQVNSFHniakRKCEDLMRQGQSIKHIL-----HKETDLEKNDYriWLKASIDIIIHLL 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462513706  491 KQCLPLRGNDQSVSSVNKGNFLELLEMRAKDKGEETFRLMN-SQVDFYNSTQIQSDIIEIIKTEMLQDIVNEInDSSAFS 569
Cdd:pfam14291   77 HQGLPLRGHDESEESTNKGLFVELLKYTAGQDEVVKKVLKNaPKNNTYTSPPIQNDIVNCFSNEVTRSIIEEM-DNDVFG 155

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462513706  570 IICDETINSAMKEQLSICVRYPQKSSKAIlikERFLGFVDTEEMTGTHLHRTIKTYLQQIGVDMDKIHGQAYDSTTNLKI 649
Cdd:pfam14291  156 ILVDETADASDKEQMAIVFRYVDKYGVPI---ERFIGVIHVQETSSLSLKSAIDSLLKSLGISLKKLRSQCYDGASNMSG 232


                   ...
gi 2462513706  650 KFN 652
Cdd:pfam14291  233 EFN 235
Dimer_Tnp_hAT pfam05699
hAT family C-terminal dimerization region; This dimerization region is found at the C terminus ...
 954-1043 6.77e-14

hAT family C-terminal dimerization region; This dimerization region is found at the C terminus of the transposases of elements belonging to the Activator superfamily (hAT element superfamily). The isolated dimerization region forms extremely stable dimers in vitro.


:

Pssm-ID: 399013  Cd Length: 83  Bit Score: 68.06  E-value: 6.77e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462513706  954 FYRHYAKLNFVIDDSCINfvsLGCLFIQHglHSNIPCLSKLLYIALSWPITSASTENSFSTLprLKTYLCNTMGQEKLTG 1033
Cdd:pfam05699    1 ELDQYLSEPVLPRNEDFD---PLEWWKEN--SSRYPNLSKLARDILSIPVSSAASERSFSTL--GKVILESRNRLEPLNV 73

                           90
                   ....*....|
gi 2462513706 1034 PALMAVEQEL 1043
Cdd:pfam05699   74 EALLCIEDWL 83
zf-FCS pfam06467
MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...
 56-96 3.04e-05

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.


:

Pssm-ID: 428958  Cd Length: 40  Bit Score: 41.97  E-value: 3.04e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 2462513706   56 SKRTCSNCSKDILNPKDVISVQLEDttSCKTFCSLSCLSSY 96
Cdd:pfam06467    2 VKATCWFCKKLIKNKPTVIVLQNDG--SVGQFCSQSCLDSY 40
ZnF_TTF super family cl02692
zinc finger in transposases and transcription factors;
377-456 1.17e-04

zinc finger in transposases and transcription factors;


The actual alignment was detected with superfamily member smart00597:

Pssm-ID: 214739  Cd Length: 91  Bit Score: 42.09  E-value: 1.17e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462513706   377 KSRSIKKSCCADFEC-LENS-KKDVAFCYSCQLFCQKYFScGRESFATHGTSNWKKTLEKFRKHEKSEMH---LKSLEFW 451
Cdd:smart00597    1 KPRRFQKSWFHQFPDwLEYSvEKDAAFCKYCYLFRPGRDG-GSDLFVTEGFCSWKKERIRLKQHEVSKRHrnaRLCVNLM 79


                    ....*
gi 2462513706   452 REYQF 456
Cdd:smart00597   80 EQRQS 84
 
Name Accession Description Interval E-value
DUF4371 pfam14291
Domain of unknown function (DUF4371);
419-652 3.64e-29

Domain of unknown function (DUF4371);


Pssm-ID: 405048  Cd Length: 236  Bit Score: 116.95  E-value: 3.64e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462513706  419 SFATHGTSNWKK--TLEKFRKHEKSEMH----LKSLEFWREYQFCDGAVsddlsIHSKQIEGNKK--YLKLIIENILFLG 490
Cdd:pfam14291    2 AFLSTGFCSWNKadRLDQFVGHQVNSFHniakRKCEDLMRQGQSIKHIL-----HKETDLEKNDYriWLKASIDIIIHLL 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462513706  491 KQCLPLRGNDQSVSSVNKGNFLELLEMRAKDKGEETFRLMN-SQVDFYNSTQIQSDIIEIIKTEMLQDIVNEInDSSAFS 569
Cdd:pfam14291   77 HQGLPLRGHDESEESTNKGLFVELLKYTAGQDEVVKKVLKNaPKNNTYTSPPIQNDIVNCFSNEVTRSIIEEM-DNDVFG 155

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462513706  570 IICDETINSAMKEQLSICVRYPQKSSKAIlikERFLGFVDTEEMTGTHLHRTIKTYLQQIGVDMDKIHGQAYDSTTNLKI 649
Cdd:pfam14291  156 ILVDETADASDKEQMAIVFRYVDKYGVPI---ERFIGVIHVQETSSLSLKSAIDSLLKSLGISLKKLRSQCYDGASNMSG 232


                   ...
gi 2462513706  650 KFN 652
Cdd:pfam14291  233 EFN 235
Dimer_Tnp_hAT pfam05699
hAT family C-terminal dimerization region; This dimerization region is found at the C terminus ...
 954-1043 6.77e-14

hAT family C-terminal dimerization region; This dimerization region is found at the C terminus of the transposases of elements belonging to the Activator superfamily (hAT element superfamily). The isolated dimerization region forms extremely stable dimers in vitro.


Pssm-ID: 399013  Cd Length: 83  Bit Score: 68.06  E-value: 6.77e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462513706  954 FYRHYAKLNFVIDDSCINfvsLGCLFIQHglHSNIPCLSKLLYIALSWPITSASTENSFSTLprLKTYLCNTMGQEKLTG 1033
Cdd:pfam05699    1 ELDQYLSEPVLPRNEDFD---PLEWWKEN--SSRYPNLSKLARDILSIPVSSAASERSFSTL--GKVILESRNRLEPLNV 73

                           90
                   ....*....|
gi 2462513706 1034 PALMAVEQEL 1043
Cdd:pfam05699   74 EALLCIEDWL 83
zf-FCS pfam06467
MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...
 56-96 3.04e-05

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.


Pssm-ID: 428958  Cd Length: 40  Bit Score: 41.97  E-value: 3.04e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 2462513706   56 SKRTCSNCSKDILNPKDVISVQLEDttSCKTFCSLSCLSSY 96
Cdd:pfam06467    2 VKATCWFCKKLIKNKPTVIVLQNDG--SVGQFCSQSCLDSY 40
TRASH smart00746
metallochaperone-like domain;
60-100 8.98e-05

metallochaperone-like domain;


Pssm-ID: 214799  Cd Length: 39  Bit Score: 40.82  E-value: 8.98e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 2462513706    60 CSNCSKDILNPKDVISVQLEDTTscKTFCSLSCLSSYEEKR 100
Cdd:smart00746    1 CSFCGKDIYNPGTGIMVVNDGKV--YYFCSSKCLSKFKKKR 39
ZnF_TTF smart00597
zinc finger in transposases and transcription factors;
377-456 1.17e-04

zinc finger in transposases and transcription factors;


Pssm-ID: 214739  Cd Length: 91  Bit Score: 42.09  E-value: 1.17e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462513706   377 KSRSIKKSCCADFEC-LENS-KKDVAFCYSCQLFCQKYFScGRESFATHGTSNWKKTLEKFRKHEKSEMH---LKSLEFW 451
Cdd:smart00597    1 KPRRFQKSWFHQFPDwLEYSvEKDAAFCKYCYLFRPGRDG-GSDLFVTEGFCSWKKERIRLKQHEVSKRHrnaRLCVNLM 79


                    ....*
gi 2462513706   452 REYQF 456
Cdd:smart00597   80 EQRQS 84
 
Name Accession Description Interval E-value
DUF4371 pfam14291
Domain of unknown function (DUF4371);
419-652 3.64e-29

Domain of unknown function (DUF4371);


Pssm-ID: 405048  Cd Length: 236  Bit Score: 116.95  E-value: 3.64e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462513706  419 SFATHGTSNWKK--TLEKFRKHEKSEMH----LKSLEFWREYQFCDGAVsddlsIHSKQIEGNKK--YLKLIIENILFLG 490
Cdd:pfam14291    2 AFLSTGFCSWNKadRLDQFVGHQVNSFHniakRKCEDLMRQGQSIKHIL-----HKETDLEKNDYriWLKASIDIIIHLL 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462513706  491 KQCLPLRGNDQSVSSVNKGNFLELLEMRAKDKGEETFRLMN-SQVDFYNSTQIQSDIIEIIKTEMLQDIVNEInDSSAFS 569
Cdd:pfam14291   77 HQGLPLRGHDESEESTNKGLFVELLKYTAGQDEVVKKVLKNaPKNNTYTSPPIQNDIVNCFSNEVTRSIIEEM-DNDVFG 155

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462513706  570 IICDETINSAMKEQLSICVRYPQKSSKAIlikERFLGFVDTEEMTGTHLHRTIKTYLQQIGVDMDKIHGQAYDSTTNLKI 649
Cdd:pfam14291  156 ILVDETADASDKEQMAIVFRYVDKYGVPI---ERFIGVIHVQETSSLSLKSAIDSLLKSLGISLKKLRSQCYDGASNMSG 232


                   ...
gi 2462513706  650 KFN 652
Cdd:pfam14291  233 EFN 235
Dimer_Tnp_hAT pfam05699
hAT family C-terminal dimerization region; This dimerization region is found at the C terminus ...
 954-1043 6.77e-14

hAT family C-terminal dimerization region; This dimerization region is found at the C terminus of the transposases of elements belonging to the Activator superfamily (hAT element superfamily). The isolated dimerization region forms extremely stable dimers in vitro.


Pssm-ID: 399013  Cd Length: 83  Bit Score: 68.06  E-value: 6.77e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462513706  954 FYRHYAKLNFVIDDSCINfvsLGCLFIQHglHSNIPCLSKLLYIALSWPITSASTENSFSTLprLKTYLCNTMGQEKLTG 1033
Cdd:pfam05699    1 ELDQYLSEPVLPRNEDFD---PLEWWKEN--SSRYPNLSKLARDILSIPVSSAASERSFSTL--GKVILESRNRLEPLNV 73

                           90
                   ....*....|
gi 2462513706 1034 PALMAVEQEL 1043
Cdd:pfam05699   74 EALLCIEDWL 83
zf-FCS pfam06467
MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...
 56-96 3.04e-05

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.


Pssm-ID: 428958  Cd Length: 40  Bit Score: 41.97  E-value: 3.04e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 2462513706   56 SKRTCSNCSKDILNPKDVISVQLEDttSCKTFCSLSCLSSY 96
Cdd:pfam06467    2 VKATCWFCKKLIKNKPTVIVLQNDG--SVGQFCSQSCLDSY 40
TRASH smart00746
metallochaperone-like domain;
60-100 8.98e-05

metallochaperone-like domain;


Pssm-ID: 214799  Cd Length: 39  Bit Score: 40.82  E-value: 8.98e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 2462513706    60 CSNCSKDILNPKDVISVQLEDTTscKTFCSLSCLSSYEEKR 100
Cdd:smart00746    1 CSFCGKDIYNPGTGIMVVNDGKV--YYFCSSKCLSKFKKKR 39
ZnF_TTF smart00597
zinc finger in transposases and transcription factors;
377-456 1.17e-04

zinc finger in transposases and transcription factors;


Pssm-ID: 214739  Cd Length: 91  Bit Score: 42.09  E-value: 1.17e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462513706   377 KSRSIKKSCCADFEC-LENS-KKDVAFCYSCQLFCQKYFScGRESFATHGTSNWKKTLEKFRKHEKSEMH---LKSLEFW 451
Cdd:smart00597    1 KPRRFQKSWFHQFPDwLEYSvEKDAAFCKYCYLFRPGRDG-GSDLFVTEGFCSWKKERIRLKQHEVSKRHrnaRLCVNLM 79


                    ....*
gi 2462513706   452 REYQF 456
Cdd:smart00597   80 EQRQS 84
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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