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Conserved domains on  [gi|2462575433|ref|XP_054199066|]
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tetratricopeptide repeat protein 7A isoform X3 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TTC7_N super family cl44857
Tetratricopeptide repeat protein 7 N-terminal; This is the N-terminal domain of TTC7, a ...
 1-403 2.34e-152

Tetratricopeptide repeat protein 7 N-terminal; This is the N-terminal domain of TTC7, a protein that forms the regulatory subunit of the PI4KIIIalpha complex (also known as PI4KA). This complex is composed of PI4KIIIalpha, TTC7 and FAM126A and catalyzes the first step in plasma membrane phosphoinositide synthesis. This TTC7 N-terminal domain contains basic residues suitable for interaction with the acidic inner leaflet of the plasma membrane and is required for localising the active site near its substrate. TTC7 acts as a bridge between PI4KA and EFR3B-FAM126A, via direct interactions. ERF3B is not part of the complex but contributes to its recruitment to the membrane.


The actual alignment was detected with superfamily member pfam19440:

Pssm-ID: 466084  Cd Length: 386  Bit Score: 449.61  E-value: 2.34e-152
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575433   1 MAAKGAHGSYlKVESELERCRAEGHWDRMPELVRQLQTLSMPggggnrrgspsaaftfpdTDDFGKLLLAEALLEQCLKE 80
Cdd:pfam19440   1 MTSRISFSGY-RLETEIERCRSECQWDKVPELVEQLKAKRIA------------------NDDMANLLLGEGKLEQYLKE 61

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575433  81 NHAKIKDSMpllEKNEPKMSEAKNYLSSILNHGRLSPQYMCEAMLILGKLHYVEGSYRDAISMYARAGIDDMSMENKPLY 160
Cdd:pfam19440  62 NPPILENST---EKNQPKLSEAKKHLTSALDRGNLKPEFLQEAHLLLAKLNYVEGDYREALNMYARAGLDDLTLKELPVY 138

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575433 161 QMRLLSEAFVIKGLSLERLPNSIASRFRLTEREEEVITCFERASWIAQVFLQELEKTTNNSTSRHLK-GCHPLDYELTYF 239
Cdd:pfam19440 139 RLRLLAEAYAIKGLCLEKQAVSSSSRVRLAEREEEMITCYEKAGDIALLYLQELERINSNTQNRSPKpGPPSQEQELGFF 218

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575433 240 LEAALQSAYVKNLKKGNIVKGMRELREVLRTVETKATQNFKVMAAKHLAGVLLHSLSEECYWSPLSHPLPEFMGKEES-S 318
Cdd:pfam19440 219 LETALQRAYVLYFKKGNLARGVGRYREILRAVETRTTQNLRMTIARQLAEVLLRGVCEQSYWNPLEDPPPQSLLDEPLkG 298

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575433 319 FATQA---LRKPHLYEGDNLYCPKDNIEEALLLLLISESMATRDVVLSRVPEQEEDRTVSLQNAAAIYDLLSITLGRRGQ 395
Cdd:pfam19440 299 TNTKNytpSRKPRVYSGENIFCPQDNVEEALLLLLISESMANRDAVLSRSPEHREARIISLQNATAVYDLLTIAMGRRGQ 378


                  ....*...
gi 2462575433 396 YVMLSECL 403
Cdd:pfam19440 379 YEMLSECL 386
Spy super family cl27809
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 627-764 2.23e-20

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


The actual alignment was detected with superfamily member COG3914:

Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 96.22  E-value: 2.23e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575433 627 LEQIWLQAAELFMEQQHLKEAGFCIQEAAGLFPTSHSVLYMRGRLAEVKGNLEEAKQLYKEALTVNPDGVRIMHSLGLML 706
Cdd:COG3914    77 LAALLELAALLLQALGRYEEALALYRRALALNPDNAEALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEAL 156

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2462575433 707 SRLGHKSLAQKVLRDAVERQSTCHEAWQGLGEVLQAQGQNEAAVDCFLTALELEASSP 764
Cdd:COG3914   157 RRLGRLEEAIAALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALELDPDNA 214
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 361-545 2.33e-05

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 47.03  E-value: 2.33e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575433 361 VLSRVPEQEEDRTVSLQNAAAIYDllsitlgRRGQYVMLSECLERAMKFAFGEFHLWYQVALSMVACGKSAYAVSLLREC 440
Cdd:COG2956    98 LLEKLLELDPDDAEALRLLAEIYE-------QEGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIEALEKA 170

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575433 441 VKLRPSDPTVPLMAAKVCIGSLRWiSSAMEQLQEALKVRKDDAHALHLLALLFSAQKHHQHALDVVNMAITEHPENfNLM 520
Cdd:COG2956   171 LKLDPDCARALLLLAELYLEQGDY-EEAIAALERALEQDPDYLPALPRLAELYEKLGDPEEALELLRKALELDPSD-DLL 248

                         170       180
                  ....*....|....*....|....*
gi 2462575433 521 FTKVKLEQVLKGPEEALVTCRQVLR 545
Cdd:COG2956   249 LALADLLERKEGLEAALALLERQLR 273
 
Name Accession Description Interval E-value
TTC7_N pfam19440
Tetratricopeptide repeat protein 7 N-terminal; This is the N-terminal domain of TTC7, a ...
 1-403 2.34e-152

Tetratricopeptide repeat protein 7 N-terminal; This is the N-terminal domain of TTC7, a protein that forms the regulatory subunit of the PI4KIIIalpha complex (also known as PI4KA). This complex is composed of PI4KIIIalpha, TTC7 and FAM126A and catalyzes the first step in plasma membrane phosphoinositide synthesis. This TTC7 N-terminal domain contains basic residues suitable for interaction with the acidic inner leaflet of the plasma membrane and is required for localising the active site near its substrate. TTC7 acts as a bridge between PI4KA and EFR3B-FAM126A, via direct interactions. ERF3B is not part of the complex but contributes to its recruitment to the membrane.


Pssm-ID: 466084  Cd Length: 386  Bit Score: 449.61  E-value: 2.34e-152
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575433   1 MAAKGAHGSYlKVESELERCRAEGHWDRMPELVRQLQTLSMPggggnrrgspsaaftfpdTDDFGKLLLAEALLEQCLKE 80
Cdd:pfam19440   1 MTSRISFSGY-RLETEIERCRSECQWDKVPELVEQLKAKRIA------------------NDDMANLLLGEGKLEQYLKE 61

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575433  81 NHAKIKDSMpllEKNEPKMSEAKNYLSSILNHGRLSPQYMCEAMLILGKLHYVEGSYRDAISMYARAGIDDMSMENKPLY 160
Cdd:pfam19440  62 NPPILENST---EKNQPKLSEAKKHLTSALDRGNLKPEFLQEAHLLLAKLNYVEGDYREALNMYARAGLDDLTLKELPVY 138

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575433 161 QMRLLSEAFVIKGLSLERLPNSIASRFRLTEREEEVITCFERASWIAQVFLQELEKTTNNSTSRHLK-GCHPLDYELTYF 239
Cdd:pfam19440 139 RLRLLAEAYAIKGLCLEKQAVSSSSRVRLAEREEEMITCYEKAGDIALLYLQELERINSNTQNRSPKpGPPSQEQELGFF 218

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575433 240 LEAALQSAYVKNLKKGNIVKGMRELREVLRTVETKATQNFKVMAAKHLAGVLLHSLSEECYWSPLSHPLPEFMGKEES-S 318
Cdd:pfam19440 219 LETALQRAYVLYFKKGNLARGVGRYREILRAVETRTTQNLRMTIARQLAEVLLRGVCEQSYWNPLEDPPPQSLLDEPLkG 298

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575433 319 FATQA---LRKPHLYEGDNLYCPKDNIEEALLLLLISESMATRDVVLSRVPEQEEDRTVSLQNAAAIYDLLSITLGRRGQ 395
Cdd:pfam19440 299 TNTKNytpSRKPRVYSGENIFCPQDNVEEALLLLLISESMANRDAVLSRSPEHREARIISLQNATAVYDLLTIAMGRRGQ 378


                  ....*...
gi 2462575433 396 YVMLSECL 403
Cdd:pfam19440 379 YEMLSECL 386
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 627-764 2.23e-20

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 96.22  E-value: 2.23e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575433 627 LEQIWLQAAELFMEQQHLKEAGFCIQEAAGLFPTSHSVLYMRGRLAEVKGNLEEAKQLYKEALTVNPDGVRIMHSLGLML 706
Cdd:COG3914    77 LAALLELAALLLQALGRYEEALALYRRALALNPDNAEALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEAL 156

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2462575433 707 SRLGHKSLAQKVLRDAVERQSTCHEAWQGLGEVLQAQGQNEAAVDCFLTALELEASSP 764
Cdd:COG3914   157 RRLGRLEEAIAALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALELDPDNA 214
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 521-772 3.69e-08

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 56.92  E-value: 3.69e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575433 521 FTKVKLEQVLKGPEEALVTCRQVLRLWQTLYSFSQLGGLEKDGSFGEGlTMKKQSGMHLTLPDAhDADSGSRRASSIAAS 600
Cdd:TIGR00990 242 FAESKAKEILETKPENLPSVTFVGNYLQSFRPKPRPAGLEDSNELDEE-TGNGQLQLGLKSPES-KADESYEEAARAFEK 319

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575433 601 RLE-------EAMS-ELTMPSSVLKQGP----------MQLWTTLEQIWLQAAELFMEQQHLKEAGFCIQEAAGLFPTSH 662
Cdd:TIGR00990 320 ALDlgklgekEAIAlNLRGTFKCLKGKHlealadlsksIELDPRVTQSYIKRASMNLELGDPDKAEEDFDKALKLNSEDP 399

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575433 663 SVLYMRGRLAEVKGNLEEAKQLYKEALTVNPDGVRIMHSLGLMLSRLGHKSLAQKVLRDAVERQSTCHEAWQGLGEVLQA 742
Cdd:TIGR00990 400 DIYYHRAQLHFIKGEFAQAGKDYQKSIDLDPDFIFSHIQLGVTQYKEGSIASSMATFRRCKKNFPEAPDVYNYYGELLLD 479

                         250       260       270
                  ....*....|....*....|....*....|
gi 2462575433 743 QGQNEAAVDCFLTALELEASSPVLPFSIIP 772
Cdd:TIGR00990 480 QNKFDEAIEKFDTAIELEKETKPMYMNVLP 509
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 361-545 2.33e-05

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 47.03  E-value: 2.33e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575433 361 VLSRVPEQEEDRTVSLQNAAAIYDllsitlgRRGQYVMLSECLERAMKFAFGEFHLWYQVALSMVACGKSAYAVSLLREC 440
Cdd:COG2956    98 LLEKLLELDPDDAEALRLLAEIYE-------QEGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIEALEKA 170

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575433 441 VKLRPSDPTVPLMAAKVCIGSLRWiSSAMEQLQEALKVRKDDAHALHLLALLFSAQKHHQHALDVVNMAITEHPENfNLM 520
Cdd:COG2956   171 LKLDPDCARALLLLAELYLEQGDY-EEAIAALERALEQDPDYLPALPRLAELYEKLGDPEEALELLRKALELDPSD-DLL 248

                         170       180
                  ....*....|....*....|....*
gi 2462575433 521 FTKVKLEQVLKGPEEALVTCRQVLR 545
Cdd:COG2956   249 LALADLLERKEGLEAALALLERQLR 273
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 353-765 2.49e-05

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 47.77  E-value: 2.49e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575433 353 ESMATRDVVLSRVPEQEEdrtvslqnAAAIYDLLSItlgRRGQYVMLSECLERAMKFAFGEFHLWYQVALSMVACGKSAY 432
Cdd:TIGR02917 245 EAEKHADALLKKAPNSPL--------AHYLKALVDF---QKKNYEDARETLQDALKSAPEYLPALLLAGASEYQLGNLEQ 313

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575433 433 AVSLLRECVKLRPSDPTVPLMAAKVCIGSLRwISSAMEQLQEALKVRKDDAHALHLLALLFSAQKHHQHALDVVNMAITE 512
Cdd:TIGR02917 314 AYQYLNQILKYAPNSHQARRLLASIQLRLGR-VDEAIATLSPALGLDPDDPAALSLLGEAYLALGDFEKAAEYLAKATEL 392

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575433 513 HPENFNLmFTKVKLEQVLKG-PEEALVTCRQVLRLwqtlysfsqlgglekDGSFGEGLTMkkqsgMHLTLPDAHDADsgs 591
Cdd:TIGR02917 393 DPENAAA-RTQLGISKLSQGdPSEAIADLETAAQL---------------DPELGRADLL-----LILSYLRSGQFD--- 448

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575433 592 rRASSIAASRLEEamseltMPSSVLkqgpmqLWTTLEQIWLQAAELFMEQQHLKEAgfcIQEAAGLFPTSHSVLymrgRL 671
Cdd:TIGR02917 449 -KALAAAKKLEKK------QPDNAS------LHNLLGAIYLGKGDLAKAREAFEKA---LSIEPDFFPAAANLA----RI 508

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575433 672 AEVKGNLEEAKQLYKEALTVNPDGVRIMHSLGLMLSRLGHKS---------------------------LAQK------- 717
Cdd:TIGR02917 509 DIQEGNPDDAIQRFEKVLTIDPKNLRAILALAGLYLRTGNEEeavawlekaaelnpqeiepalalaqyyLGKGqlkkala 588

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*...
gi 2462575433 718 VLRDAVERQSTCHEAWQGLGEVLQAQGQNEAAVDCFLTALELEASSPV 765
Cdd:TIGR02917 589 ILNEAADAAPDSPEAWLMLGRAQLAAGDLNKAVSSFKKLLALQPDSAL 636
TPR_11 pfam13414
TPR repeat;
675-710 1.29e-03

TPR repeat;


Pssm-ID: 315977 [Multi-domain]  Cd Length: 42  Bit Score: 37.07  E-value: 1.29e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 2462575433 675 KGNLEEAKQLYKEALTVNPDGVRIMHSLGLMLSRLG 710
Cdd:pfam13414   7 QGKYEEAIEAYKKALKLDPDNPEAYYNLGLAYYKLG 42
 
Name Accession Description Interval E-value
TTC7_N pfam19440
Tetratricopeptide repeat protein 7 N-terminal; This is the N-terminal domain of TTC7, a ...
 1-403 2.34e-152

Tetratricopeptide repeat protein 7 N-terminal; This is the N-terminal domain of TTC7, a protein that forms the regulatory subunit of the PI4KIIIalpha complex (also known as PI4KA). This complex is composed of PI4KIIIalpha, TTC7 and FAM126A and catalyzes the first step in plasma membrane phosphoinositide synthesis. This TTC7 N-terminal domain contains basic residues suitable for interaction with the acidic inner leaflet of the plasma membrane and is required for localising the active site near its substrate. TTC7 acts as a bridge between PI4KA and EFR3B-FAM126A, via direct interactions. ERF3B is not part of the complex but contributes to its recruitment to the membrane.


Pssm-ID: 466084  Cd Length: 386  Bit Score: 449.61  E-value: 2.34e-152
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575433   1 MAAKGAHGSYlKVESELERCRAEGHWDRMPELVRQLQTLSMPggggnrrgspsaaftfpdTDDFGKLLLAEALLEQCLKE 80
Cdd:pfam19440   1 MTSRISFSGY-RLETEIERCRSECQWDKVPELVEQLKAKRIA------------------NDDMANLLLGEGKLEQYLKE 61

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575433  81 NHAKIKDSMpllEKNEPKMSEAKNYLSSILNHGRLSPQYMCEAMLILGKLHYVEGSYRDAISMYARAGIDDMSMENKPLY 160
Cdd:pfam19440  62 NPPILENST---EKNQPKLSEAKKHLTSALDRGNLKPEFLQEAHLLLAKLNYVEGDYREALNMYARAGLDDLTLKELPVY 138

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575433 161 QMRLLSEAFVIKGLSLERLPNSIASRFRLTEREEEVITCFERASWIAQVFLQELEKTTNNSTSRHLK-GCHPLDYELTYF 239
Cdd:pfam19440 139 RLRLLAEAYAIKGLCLEKQAVSSSSRVRLAEREEEMITCYEKAGDIALLYLQELERINSNTQNRSPKpGPPSQEQELGFF 218

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575433 240 LEAALQSAYVKNLKKGNIVKGMRELREVLRTVETKATQNFKVMAAKHLAGVLLHSLSEECYWSPLSHPLPEFMGKEES-S 318
Cdd:pfam19440 219 LETALQRAYVLYFKKGNLARGVGRYREILRAVETRTTQNLRMTIARQLAEVLLRGVCEQSYWNPLEDPPPQSLLDEPLkG 298

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575433 319 FATQA---LRKPHLYEGDNLYCPKDNIEEALLLLLISESMATRDVVLSRVPEQEEDRTVSLQNAAAIYDLLSITLGRRGQ 395
Cdd:pfam19440 299 TNTKNytpSRKPRVYSGENIFCPQDNVEEALLLLLISESMANRDAVLSRSPEHREARIISLQNATAVYDLLTIAMGRRGQ 378


                  ....*...
gi 2462575433 396 YVMLSECL 403
Cdd:pfam19440 379 YEMLSECL 386
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 627-764 2.23e-20

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 96.22  E-value: 2.23e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575433 627 LEQIWLQAAELFMEQQHLKEAGFCIQEAAGLFPTSHSVLYMRGRLAEVKGNLEEAKQLYKEALTVNPDGVRIMHSLGLML 706
Cdd:COG3914    77 LAALLELAALLLQALGRYEEALALYRRALALNPDNAEALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEAL 156

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2462575433 707 SRLGHKSLAQKVLRDAVERQSTCHEAWQGLGEVLQAQGQNEAAVDCFLTALELEASSP 764
Cdd:COG3914   157 RRLGRLEEAIAALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALELDPDNA 214
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
629-760 2.01e-18

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 85.44  E-value: 2.01e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575433 629 QIWLQAAELFMEQQHLKEAGFCIQEAAGLFPTSHSVLYMRGRLAEVKGNLEEAKQLYKEALTVNPDGVRIMHSLGLMLSR 708
Cdd:COG0457     9 EAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLALQA 88

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2462575433 709 LGHKSLAQKVLRDAVERQSTCHEAWQGLGEVLQAQGQNEAAVDCFLTALELE 760
Cdd:COG0457    89 LGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELD 140
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 629-761 5.08e-16

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 75.61  E-value: 5.08e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575433 629 QIWLQAAELFMEQQHLKEAGFCIQEAAGLFPTSHSVLYMRGRLAEVKGNLEEAKQLYKEALTVNPDGVRIMHSLGLMLSR 708
Cdd:COG4783     5 EALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLK 84

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2462575433 709 LGHKSLAQKVLRDAVERQSTCHEAWQGLGEVLQAQGQNEAAVDCFLTALELEA 761
Cdd:COG4783    85 AGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALELDP 137
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 597-766 4.70e-15

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 76.31  E-value: 4.70e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575433 597 IAASRLEEAMSELtmpSSVLKQGPMQlwttlEQIWLQAAELFMEQQHLKEAGFCIQEAAGLFPTSHSVLYMRGRLAEVKG 676
Cdd:COG2956    87 LKAGLLDRAEELL---EKLLELDPDD-----AEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQG 158

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575433 677 NLEEAKQLYKEALTVNPDGVRIMHSLGLMLSRLGHKSLAQKVLRDAVERQSTCHEAWQGLGEVLQAQGQNEAAVDCFLTA 756
Cdd:COG2956   159 DYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQDPDYLPALPRLAELYEKLGDPEEALELLRKA 238

                         170
                  ....*....|
gi 2462575433 757 LELEASSPVL 766
Cdd:COG2956   239 LELDPSDDLL 248
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
629-761 1.07e-14

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 74.66  E-value: 1.07e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575433 629 QIWLQAAELFMEQQHLKEAGFCIQEAAGLFPTSHSVLYMRGRLAEVKGNLEEAKQLYKEALTVNPDGVRIMHSLGLMLSR 708
Cdd:COG0457    43 EALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLE 122

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2462575433 709 LGHKSLAQKVLRDAVERQSTCHEAWQGLGEVLQAQGQNEAAVDCFLTALELEA 761
Cdd:COG0457   123 LGRYDEAIEAYERALELDPDDADALYNLGIALEKLGRYEEALELLEKLEAAAL 175
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
657-764 1.17e-14

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 74.27  E-value: 1.17e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575433 657 LFPTSHSVLYMRGRLAEVKGNLEEAKQLYKEALTVNPDGVRIMHSLGLMLSRLGHKSLAQKVLRDAVERQSTCHEAWQGL 736
Cdd:COG0457     3 LDPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNL 82

                          90       100
                  ....*....|....*....|....*...
gi 2462575433 737 GEVLQAQGQNEAAVDCFLTALELEASSP 764
Cdd:COG0457    83 GLALQALGRYEEALEDYDKALELDPDDA 110
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 628-760 2.29e-14

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 74.00  E-value: 2.29e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575433 628 EQIWLQAAELFMEQQHLKEAGFCIQEAAGLFPTSHSVLYMRGRLAEVKGNLEEAKQLYKEALTVNPDGVRIMHSLGLMLS 707
Cdd:COG2956    76 AEALLELAQDYLKAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCELAELYL 155

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2462575433 708 RLGHKSLAQKVLRDAVERQSTCHEAWQGLGEVLQAQGQNEAAVDCFLTALELE 760
Cdd:COG2956   156 EQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQD 208
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 627-764 4.85e-14

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 75.80  E-value: 4.85e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575433 627 LEQIWLQAAELFMEQQHLKEAGFCIQEAAGLFPTSHSVLYMRGRLAEVKGNLEEAKQLYKEALTVNPDGVRIMHSLGLML 706
Cdd:COG3914    43 LALLLLAALAEAAAAALLALAAGEAAAAAAALLLLAALLELAALLLQALGRYEEALALYRRALALNPDNAEALFNLGNLL 122

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2462575433 707 SRLGHKSLAQKVLRDAVERQSTCHEAWQGLGEVLQAQGQNEAAVDCFLTALELEASSP 764
Cdd:COG3914   123 LALGRLEEALAALRRALALNPDFAEAYLNLGEALRRLGRLEEAIAALRRALELDPDNA 180
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 663-764 2.41e-13

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 67.91  E-value: 2.41e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575433 663 SVLYMRGRLAEVKGNLEEAKQLYKEALTVNPDGVRIMHSLGLMLSRLGHKSLAQKVLRDAVERQSTCHEAWQGLGEVLQA 742
Cdd:COG4783     5 EALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLK 84

                          90       100
                  ....*....|....*....|..
gi 2462575433 743 QGQNEAAVDCFLTALELEASSP 764
Cdd:COG4783    85 AGDYDEALALLEKALKLDPEHP 106
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 628-758 5.83e-13

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 69.76  E-value: 5.83e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575433 628 EQIWLQAAELFMEQQHLKEAGFCIQEAAGLFPTSHSVLYMRGRLAEVKGNLEEAKQLYKEALTVNPDGVRIMHSLGLMLS 707
Cdd:COG2956   144 AHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQDPDYLPALPRLAELYE 223

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2462575433 708 RLGHKSLAQKVLRDAVERQSTcHEAWQGLGEVLQAQGQNEAAVDCFLTALE 758
Cdd:COG2956   224 KLGDPEEALELLRKALELDPS-DDLLLALADLLERKEGLEAALALLERQLR 273
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 627-760 2.93e-12

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 65.37  E-value: 2.93e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575433 627 LEQIWLQAAELFMEQQHLKEAGFCIQEAAGLFPTSHSVLYMRgrlaevKGNLEEAKQLYKEALTVNPDGVRIMHSLGLML 706
Cdd:COG5010    25 EKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNK------LGDFEESLALLEQALQLDPNNPELYYNLALLY 98

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2462575433 707 SRLGHKSLAQKVLRDAVERQSTCHEAWQGLGEVLQAQGQNEAAVDCFLTALELE 760
Cdd:COG5010    99 SRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAKAALQRALGTS 152
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 646-759 6.65e-12

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 63.49  E-value: 6.65e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575433 646 EAGFCIQEAAGLFPTSHSVLYMRGRLAEVKGNLEEAKQLYKEALTVNPDGVRIMHSLGLMLSRLGHKSLAQKVLRDAVER 725
Cdd:COG4235     1 EAIARLRQALAANPNDAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALAL 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 2462575433 726 QSTCHEAWQGLGEVLQAQGQNEAAVDCFLTALEL 759
Cdd:COG4235    81 DPDNPEALYLLGLAAFQQGDYAEAIAAWQKLLAL 114
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 631-759 2.34e-11

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 65.14  E-value: 2.34e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575433 631 WLQAAELFMEQQHLKEAGFCIQEAAGLFPTSHSVLYMRGRLAEVKGNLEEAKQLYKEALTVNPDGVRIMHSLGLMLSRLG 710
Cdd:COG2956    11 WYFKGLNYLLNGQPDKAIDLLEEALELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAG 90

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 2462575433 711 HKSLAQKVLRDAVERQSTCHEAWQGLGEVLQAQGQNEAAVDCFLTALEL 759
Cdd:COG2956    91 LLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKL 139
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 629-764 9.40e-11

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 63.21  E-value: 9.40e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575433 629 QIWLQAAELFMEQQHLKEAGFCIQEAAGLFPTSHSVLYMRGRLAEVKGNLEEAKQLYKEALTVNPDGVRIMHSLGLMLSR 708
Cdd:COG2956    43 EAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQ 122

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462575433 709 LGHKSLAQKVLRDAVERQSTCHEAWQGLGEVLQAQGQNEAAVDCFLTALELEASSP 764
Cdd:COG2956   123 EGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCA 178
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
675-762 2.03e-10

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 57.87  E-value: 2.03e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575433 675 KGNLEEAKQLYKEALTVNPDGVRIMHSLGLMLSRLGHKSLAQKvLRDAVERQSTCHEAWQGLGEVLQAQGQNEAAVDCFL 754
Cdd:COG3063     5 LGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAIA-LEKALKLDPNNAEALLNLAELLLELGDYDEALAYLE 83


                  ....*...
gi 2462575433 755 TALELEAS 762
Cdd:COG3063    84 RALELDPS 91
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 629-770 4.77e-10

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 63.09  E-value: 4.77e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575433 629 QIWLQAAELFMEQQHLKEAGFCIQEAAGLFPTSHSVLYMRGRLAEVKGNLEEAKQLYKEALTVNPDGVRIMHSLGLMLSR 708
Cdd:COG3914   113 EALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEALRRLGRLEEAIAALRRALELDPDNAEALNNLGNALQD 192

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462575433 709 LGHKSLAQKVLRDAVERQSTCHEAWQGLGEVLQAQGQNEAAVDCFLTALELEASSPVL-PFSI 770
Cdd:COG3914   193 LGRLEEAIAAYRRALELDPDNADAHSNLLFALRQACDWEVYDRFEELLAALARGPSELsPFAL 255
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 666-764 7.63e-10

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 60.51  E-value: 7.63e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575433 666 YMRGRLAEVKGNLEEAKQLYKEALTVNPDGVRIMHSLGLMLSRLGHKSLAQKVLRDAVERQSTCHEAWQGLGEVLQAQGQ 745
Cdd:COG2956    12 YFKGLNYLLNGQPDKAIDLLEEALELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGL 91

                          90
                  ....*....|....*....
gi 2462575433 746 NEAAVDCFLTALELEASSP 764
Cdd:COG2956    92 LDRAEELLEKLLELDPDDA 110
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 629-725 2.21e-09

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 56.17  E-value: 2.21e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575433 629 QIWLQAAELFMEQQHLKEAGFCIQEAAGLFPTSHSVLYMRGRLAEVKGNLEEAKQLYKEALTVNPDGVRIMHSLGLMLSR 708
Cdd:COG4235    18 EGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALALDPDNPEALYLLGLAAFQ 97

                          90
                  ....*....|....*..
gi 2462575433 709 LGHKSLAQKVLRDAVER 725
Cdd:COG4235    98 QGDYAEAIAAWQKLLAL 114
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 521-772 3.69e-08

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 56.92  E-value: 3.69e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575433 521 FTKVKLEQVLKGPEEALVTCRQVLRLWQTLYSFSQLGGLEKDGSFGEGlTMKKQSGMHLTLPDAhDADSGSRRASSIAAS 600
Cdd:TIGR00990 242 FAESKAKEILETKPENLPSVTFVGNYLQSFRPKPRPAGLEDSNELDEE-TGNGQLQLGLKSPES-KADESYEEAARAFEK 319

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575433 601 RLE-------EAMS-ELTMPSSVLKQGP----------MQLWTTLEQIWLQAAELFMEQQHLKEAGFCIQEAAGLFPTSH 662
Cdd:TIGR00990 320 ALDlgklgekEAIAlNLRGTFKCLKGKHlealadlsksIELDPRVTQSYIKRASMNLELGDPDKAEEDFDKALKLNSEDP 399

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575433 663 SVLYMRGRLAEVKGNLEEAKQLYKEALTVNPDGVRIMHSLGLMLSRLGHKSLAQKVLRDAVERQSTCHEAWQGLGEVLQA 742
Cdd:TIGR00990 400 DIYYHRAQLHFIKGEFAQAGKDYQKSIDLDPDFIFSHIQLGVTQYKEGSIASSMATFRRCKKNFPEAPDVYNYYGELLLD 479

                         250       260       270
                  ....*....|....*....|....*....|
gi 2462575433 743 QGQNEAAVDCFLTALELEASSPVLPFSIIP 772
Cdd:TIGR00990 480 QNKFDEAIEKFDTAIELEKETKPMYMNVLP 509
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
637-726 4.00e-08

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 51.32  E-value: 4.00e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575433 637 LFMEQQHLKEAGFCIQEAAGLFPTSHSVLYMRGRLAEVKGNLEEAKQlYKEALTVNPDGVRIMHSLGLMLSRLGHKSLAQ 716
Cdd:COG3063     1 LYLKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAIA-LEKALKLDPNNAEALLNLAELLLELGDYDEAL 79

                          90
                  ....*....|
gi 2462575433 717 KVLRDAVERQ 726
Cdd:COG3063    80 AYLERALELD 89
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
689-760 4.99e-07

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 51.55  E-value: 4.99e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462575433 689 LTVNPDGVRIMHSLGLMLSRLGHKSLAQKVLRDAVERQSTCHEAWQGLGEVLQAQGQNEAAVDCFLTALELE 760
Cdd:COG0457     1 LELDPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELD 72
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
622-758 1.95e-06

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 49.53  E-value: 1.95e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575433 622 QLWTTLEQIWLQAAELFMEQQHLKEAGFCIQEAAGLFPTSHSVLYMRGRLAEVKGNLEEAKQLYKEALTVNPDGVRIMHS 701
Cdd:COG4785    67 LALPDLAQLYYERGVAYDSLGDYDLAIADFDQALELDPDLAEAYNNRGLAYLLLGDYDAALEDFDRALELDPDYAYAYLN 146

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462575433 702 LGLMLSRLGHKSLAQKVLRDAVERQSTCHEA--WQGL------------------GEVLQAQGQNEAAVDCFLTALE 758
Cdd:COG4785   147 RGIALYYLGRYELAIADLEKALELDPNDPERalWLYLaerkldpekalallledwATAYLLQGDTEEARELFKLALA 223
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
665-764 1.33e-05

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 47.22  E-value: 1.33e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575433 665 LYMRGRLAEVKGNLEEAKQLYKEALTVNPDGVRIMHSLGLMLSRLGHKSLAQKVLRDAVERQSTCHEAWQGLGEVLQAQG 744
Cdd:COG4785    76 YYERGVAYDSLGDYDLAIADFDQALELDPDLAEAYNNRGLAYLLLGDYDAALEDFDRALELDPDYAYAYLNRGIALYYLG 155

                          90       100
                  ....*....|....*....|
gi 2462575433 745 QNEAAVDCFLTALELEASSP 764
Cdd:COG4785   156 RYELAIADLEKALELDPNDP 175
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 680-764 1.83e-05

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 45.00  E-value: 1.83e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575433 680 EAKQLYKEALTVNPDGVRIMHSLGLMLSRLGHKSLAQKVLRDAVERQSTCHEAWQGLGEVLQAQGQNEAAVDCFLTALEL 759
Cdd:COG4235     1 EAIARLRQALAANPNDAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALAL 80


                  ....*
gi 2462575433 760 EASSP 764
Cdd:COG4235    81 DPDNP 85
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 361-545 2.33e-05

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 47.03  E-value: 2.33e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575433 361 VLSRVPEQEEDRTVSLQNAAAIYDllsitlgRRGQYVMLSECLERAMKFAFGEFHLWYQVALSMVACGKSAYAVSLLREC 440
Cdd:COG2956    98 LLEKLLELDPDDAEALRLLAEIYE-------QEGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIEALEKA 170

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575433 441 VKLRPSDPTVPLMAAKVCIGSLRWiSSAMEQLQEALKVRKDDAHALHLLALLFSAQKHHQHALDVVNMAITEHPENfNLM 520
Cdd:COG2956   171 LKLDPDCARALLLLAELYLEQGDY-EEAIAALERALEQDPDYLPALPRLAELYEKLGDPEEALELLRKALELDPSD-DLL 248

                         170       180
                  ....*....|....*....|....*
gi 2462575433 521 FTKVKLEQVLKGPEEALVTCRQVLR 545
Cdd:COG2956   249 LALADLLERKEGLEAALALLERQLR 273
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 353-765 2.49e-05

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 47.77  E-value: 2.49e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575433 353 ESMATRDVVLSRVPEQEEdrtvslqnAAAIYDLLSItlgRRGQYVMLSECLERAMKFAFGEFHLWYQVALSMVACGKSAY 432
Cdd:TIGR02917 245 EAEKHADALLKKAPNSPL--------AHYLKALVDF---QKKNYEDARETLQDALKSAPEYLPALLLAGASEYQLGNLEQ 313

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575433 433 AVSLLRECVKLRPSDPTVPLMAAKVCIGSLRwISSAMEQLQEALKVRKDDAHALHLLALLFSAQKHHQHALDVVNMAITE 512
Cdd:TIGR02917 314 AYQYLNQILKYAPNSHQARRLLASIQLRLGR-VDEAIATLSPALGLDPDDPAALSLLGEAYLALGDFEKAAEYLAKATEL 392

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575433 513 HPENFNLmFTKVKLEQVLKG-PEEALVTCRQVLRLwqtlysfsqlgglekDGSFGEGLTMkkqsgMHLTLPDAHDADsgs 591
Cdd:TIGR02917 393 DPENAAA-RTQLGISKLSQGdPSEAIADLETAAQL---------------DPELGRADLL-----LILSYLRSGQFD--- 448

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575433 592 rRASSIAASRLEEamseltMPSSVLkqgpmqLWTTLEQIWLQAAELFMEQQHLKEAgfcIQEAAGLFPTSHSVLymrgRL 671
Cdd:TIGR02917 449 -KALAAAKKLEKK------QPDNAS------LHNLLGAIYLGKGDLAKAREAFEKA---LSIEPDFFPAAANLA----RI 508

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575433 672 AEVKGNLEEAKQLYKEALTVNPDGVRIMHSLGLMLSRLGHKS---------------------------LAQK------- 717
Cdd:TIGR02917 509 DIQEGNPDDAIQRFEKVLTIDPKNLRAILALAGLYLRTGNEEeavawlekaaelnpqeiepalalaqyyLGKGqlkkala 588

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*...
gi 2462575433 718 VLRDAVERQSTCHEAWQGLGEVLQAQGQNEAAVDCFLTALELEASSPV 765
Cdd:TIGR02917 589 ILNEAADAAPDSPEAWLMLGRAQLAAGDLNKAVSSFKKLLALQPDSAL 636
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 629-695 2.64e-05

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 44.61  E-value: 2.64e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462575433 629 QIWLQAAELFMEQQHLKEAGFCIQEAAGLFPTSHSVLYMRGRLAEVKGNLEEAKQLYKEALTVNPDG 695
Cdd:COG4235    52 DALLDLAEALLAAGDTEEAEELLERALALDPDNPEALYLLGLAAFQQGDYAEAIAAWQKLLALLPAD 118
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
378-545 7.72e-05

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 45.00  E-value: 7.72e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575433 378 NAAAIYDLLSITLGRRGQYVMLSECLERAMKFAFGEFHLWYQVALSMVACGKSAYAVSLLRECVKLRPSDPTVPLMAAKV 457
Cdd:COG0457     6 DDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLA 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575433 458 CIGSLRWiSSAMEQLQEALKVRKDDAHALHLLALLFSAQKHHQHALDVVNMAITEHPENFNLMFTKVKLEQVLKGPEEAL 537
Cdd:COG0457    86 LQALGRY-EEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGRYEEAL 164


                  ....*...
gi 2462575433 538 VTCRQVLR 545
Cdd:COG0457   165 ELLEKLEA 172
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 696-764 1.27e-04

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 42.87  E-value: 1.27e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462575433 696 VRIMHSLGLMLSRLGHKSLAQKVLRDAVERQSTCHEAWQGLGEVLQAQGQNEAAVDCFLTALELEASSP 764
Cdd:COG4783     4 AEALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEP 72
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 664-725 1.27e-04

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 41.90  E-value: 1.27e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462575433 664 VLYMRGRLAEVKGNLEEAKQLYKEALTVNPDGVRI---MHSLGLMLSRLGHKSLAQKVLRDAVER 725
Cdd:COG1729    32 ALYWLGEAYYALGDYDEAAEAFEKLLKRYPDSPKApdaLLKLGLSYLELGDYDKARATLEELIKK 96
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 377-482 2.15e-04

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 42.10  E-value: 2.15e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575433 377 QNAAAiYDLLSITLGRRGQYVMLSECLERAMKFAFGEFHLWYQVALSMVACGKSAYAVSLLRECVKLRPSDPTVPLMAAK 456
Cdd:COG4783    36 DNPEA-FALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLAR 114

                          90       100
                  ....*....|....*....|....*.
gi 2462575433 457 VCIGSLRWiSSAMEQLQEALKVRKDD 482
Cdd:COG4783   115 AYRALGRP-DEAIAALEKALELDPDD 139
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 632-725 2.66e-04

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 44.69  E-value: 2.66e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575433 632 LQAAELFMEQQHLKEAGFCIQEAAGLFPTSHSVLYMRGRLAEVKGNLEEAKQLYKEALTVNPDGVRIMHSLGLMLSRLGH 711
Cdd:TIGR02917 163 LGLAQLALAENRFDEARALIDEVLTADPGNVDALLLKGDLLLSLGNIELALAAYRKAIALRPNNIAVLLALATILIEAGE 242

                          90
                  ....*....|....
gi 2462575433 712 KSLAQKVLRDAVER 725
Cdd:TIGR02917 243 FEEAEKHADALLKK 256
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 378-482 2.95e-04

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 44.21  E-value: 2.95e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575433 378 NAAAIYDLLSITLGRRGQYVMLSECLERAMKFAFGEFHLWYQVALSMVACGKSAYAVSLLRECVKLRPSDPTVPLMAAKV 457
Cdd:COG3914   110 DNAEALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEALRRLGRLEEAIAALRRALELDPDNAEALNNLGNA 189

                          90       100
                  ....*....|....*....|....*
gi 2462575433 458 CIGSLRWiSSAMEQLQEALKVRKDD 482
Cdd:COG3914   190 LQDLGRL-EEAIAAYRRALELDPDN 213
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 417-546 3.92e-04

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 41.33  E-value: 3.92e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575433 417 WYQVALSMVACGKSAYAVSLLRECVKLRPSDPTVPLMAAKVCIGSLRWiSSAMEQLQEALKVRKDDAHALHLLALLFSAQ 496
Cdd:COG4783     7 LYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDL-DEAIVLLHEALELDPDEPEARLNLGLALLKA 85

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 2462575433 497 KHHQHALDVVNMAITEHPENFNLMFTKVKLEQVLKGPEEALVTCRQVLRL 546
Cdd:COG4783    86 GDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALEL 135
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 671-765 4.44e-04

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 41.48  E-value: 4.44e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575433 671 LAEVKGNLEEAKQLYKEALTVNPDGVRIMHSLGLMLSRLGHKSLAQKVLRDAVERQSTCHEAWQGLGEVLQAQGQNEAAV 750
Cdd:COG5010    29 AALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNNPELYYNLALLYSRSGDKDEAK 108

                          90
                  ....*....|....*
gi 2462575433 751 DCFLTALELEASSPV 765
Cdd:COG5010   109 EYYEKALALSPDNPN 123
HemYx COG3071
Uncharacterized protein HemY, contains HemY_N domain and TPR repeats (unrelated to ...
 630-759 6.13e-04

Uncharacterized protein HemY, contains HemY_N domain and TPR repeats (unrelated to protoporphyrinogen oxidase HemY) [Function unknown];


Pssm-ID: 442305 [Multi-domain]  Cd Length: 323  Bit Score: 42.59  E-value: 6.13e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575433 630 IWLQAAELFMEQQHLKEAGFCIQEAAGLFPTSHSVLYMrGRLAEvkGNLEEAKQLYKEALTVNPDGVRIMHSLGLMLSRL 709
Cdd:COG3071   195 LAAAYARALIALGDHDEAERLLREALKRQWDPRLVRLY-GRLQG--GDPAKQLKRAEKWLKKHPNDPDLLLALGRLCLRN 271

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 2462575433 710 GHKSLAQKVLRDAVERQSTChEAWQGLGEVLQAQGQNEAAVDCFLTALEL 759
Cdd:COG3071   272 QLWGKAREYLEAALALRPSA-EAYAELARLLEQLGDPEEAAEHYRKALAL 320
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 664-759 7.21e-04

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 43.15  E-value: 7.21e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575433 664 VLYMRGRLAEVKGNLEEAKQLYKEALTVNPDGVRIMHSLGLMLSRLGHKSLAQKVLRDAVERQSTCHEAWQGLGEVLQAQ 743
Cdd:TIGR02917 127 LLALRGLAYLGLGQLELAQKSYEQALAIDPRSLYAKLGLAQLALAENRFDEARALIDEVLTADPGNVDALLLKGDLLLSL 206

                          90
                  ....*....|....*.
gi 2462575433 744 GQNEAAVDCFLTALEL 759
Cdd:TIGR02917 207 GNIELALAAYRKAIAL 222
TPR_11 pfam13414
TPR repeat;
675-710 1.29e-03

TPR repeat;


Pssm-ID: 315977 [Multi-domain]  Cd Length: 42  Bit Score: 37.07  E-value: 1.29e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 2462575433 675 KGNLEEAKQLYKEALTVNPDGVRIMHSLGLMLSRLG 710
Cdd:pfam13414   7 QGKYEEAIEAYKKALKLDPDNPEAYYNLGLAYYKLG 42
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 377-516 1.37e-03

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 39.79  E-value: 1.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575433 377 QNAAAIYDLLSITLGRRGQYVMLSECLERAMKFAFGEFHLWYQVALSMVACGKSAYAVSLLRECVKLRPSDPTVPLMAAK 456
Cdd:COG4783     1 AACAEALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575433 457 VCIgSLRWISSAMEQLQEALKVRKDDAHALHLLALLFSAQKHHQHALDVVNMAITEHPEN 516
Cdd:COG4783    81 ALL-KAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALELDPDD 139
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
476-726 1.68e-03

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 40.76  E-value: 1.68e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575433 476 LKVRKDDAHALHLLALLFSAQKHHQHALDVVNMAITEHPENFNLMFTKVKLEQVLKGPEEALVTCRQVLRLwqtlysfsq 555
Cdd:COG0457     1 LELDPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALEL--------- 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575433 556 lgglekdgsfgegltmkkqsgmhltlpDAHDAdsgsrrassiaasrleeamseltmpssvlkqgpmqlwttleQIWLQAA 635
Cdd:COG0457    72 ---------------------------DPDDA-----------------------------------------EALNNLG 83

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575433 636 ELFMEQQHLKEAGFCIQEAAGLFPTSHSVLYMRGRLAEVKGNLEEAKQLYKEALTVNPDGVRIMHSLGLMLSRLGHKSLA 715
Cdd:COG0457    84 LALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGRYEEA 163

                         250
                  ....*....|.
gi 2462575433 716 QKVLRDAVERQ 726
Cdd:COG0457   164 LELLEKLEAAA 174
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 392-546 2.03e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 40.87  E-value: 2.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575433 392 RRGQYVMLSECLERAMKFAFGEFHLWYQVALSMVACGKSAYAVSLLRECVKLRPSDPTVPLMAAKVCIGSLRWiSSAMEQ 471
Cdd:COG2956    54 RRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDW-EKAIEV 132

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462575433 472 LQEALKVRKDDAHALHLLALLFSAQKHHQHALDVVNMAITEHPENFNLMFTKVKLEQVLKGPEEALVTCRQVLRL 546
Cdd:COG2956   133 LERLLKLGPENAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQ 207
TPR_2 pfam07719
Tetratricopeptide repeat; This Pfam entry includes outlying Tetratricopeptide-like repeats ...
 664-694 2.56e-03

Tetratricopeptide repeat; This Pfam entry includes outlying Tetratricopeptide-like repeats (TPR) that are not matched by pfam00515.


Pssm-ID: 429619 [Multi-domain]  Cd Length: 33  Bit Score: 35.96  E-value: 2.56e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 2462575433 664 VLYMRGRLAEVKGNLEEAKQLYKEALTVNPD 694
Cdd:pfam07719   3 ALYNLGLAYYKLGDYEEALEAYEKALELDPN 33
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
629-694 3.24e-03

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 37.46  E-value: 3.24e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462575433 629 QIWLQAAELFMEQQHLKEAgFCIQEAAGLFPTSHSVLYMRGRLAEVKGNLEEAKQLYKEALTVNPD 694
Cdd:COG3063    27 DALNNLGLLLLEQGRYDEA-IALEKALKLDPNNAEALLNLAELLLELGDYDEALAYLERALELDPS 91
TPR_1 pfam00515
Tetratricopeptide repeat;
664-694 3.55e-03

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 35.47  E-value: 3.55e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 2462575433 664 VLYMRGRLAEVKGNLEEAKQLYKEALTVNPD 694
Cdd:pfam00515   3 ALYNLGNAYFKLGKYDEALEYYEKALELNPN 33
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 629-694 3.85e-03

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 38.25  E-value: 3.85e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462575433 629 QIWLQAAELFMEQQHLKEAGFCIQEAAGLFPTSHSVLYMRGRLAEVKGNLEEAKQLYKEALTVNPD 694
Cdd:COG4783    73 EARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALELDPD 138
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 629-693 5.86e-03

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 38.40  E-value: 5.86e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462575433 629 QIWLQAAELFMEQQHLKEAGFCIQEAAGLFPTSHSVLYMRGRLAEVKGNLEEAKQLYKEALTVNP 693
Cdd:COG5010    89 ELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAKAALQRALGTSP 153
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 675-764 6.24e-03

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 37.28  E-value: 6.24e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575433 675 KGNLEEAKQLYKEALTVNPDGV---RIMHSLGLMLSRLGHKSLAQKVLRDAVERQ---STCHEAWQGLGEVLQAQGQNEA 748
Cdd:COG1729     6 AGDYDEAIAAFKAFLKRYPNSPlapDALYWLGEAYYALGDYDEAAEAFEKLLKRYpdsPKAPDALLKLGLSYLELGDYDK 85

                          90
                  ....*....|....*.
gi 2462575433 749 AVDCFLTALELEASSP 764
Cdd:COG1729    86 ARATLEELIKKYPDSE 101
TPR_16 pfam13432
Tetratricopeptide repeat; This family is found predominantly at the C-terminus of ...
 632-695 7.33e-03

Tetratricopeptide repeat; This family is found predominantly at the C-terminus of transglutaminase enzyme core regions.


Pssm-ID: 433202 [Multi-domain]  Cd Length: 68  Bit Score: 35.77  E-value: 7.33e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462575433 632 LQAAELFMEQQHLKEAGFCIQEAAGLFPTS---HSVLYMRGRLAEVKGNLEEAKQLYKEALTVNPDG 695
Cdd:pfam13432   1 LALARAALRAGDYDDAAAALEAALARFPESpdaAAALLLLGLAALRQGRLAEAAAAYRAALRAAPGD 67
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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