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Conserved domains on  [gi|2462578315|ref|XP_054200422|]
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V-type proton ATPase subunit E 2 isoform X1 [Homo sapiens]

Protein Classification

V-type proton ATPase subunit E( domain architecture ID 11126885)

V-type ATP synthase subunit E is part of the complex that produces ATP from ADP in the presence of a proton gradient across the membrane

CATH:  3.30.2320.30
Gene Ontology:  GO:0046961|GO:1902600
PubMed:  15473999

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
vATP-synt_E pfam01991
ATP synthase (E/31 kDa) subunit; This family includes the vacuolar ATP synthase E subunit, as ...
18-216 1.05e-61

ATP synthase (E/31 kDa) subunit; This family includes the vacuolar ATP synthase E subunit, as well as the archaebacterial ATP synthase E subunit.


:

Pssm-ID: 396537 [Multi-domain]  Cd Length: 199  Bit Score: 191.44  E-value: 1.05e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462578315  18 FIEQEANEKAEEIDAKAEEEFNIEKGRLVQTQRLKIMEYYEKKEKQIEQQKKILMSTMRNQARLKVLRARNDLISDLLSE 97
Cdd:pfam01991   1 FIRQEAEEKAEEIRAKAEEEFAIEKAELVQEAEEKIDEIYEKKEKQAEMQKKIIISNAKNEARLKVLEAREEILDEVFNE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462578315  98 AKLRLSRIVEDPEVYQGLLDKLVLQGLLRLLEPVMIVRCRPQDLLLVEAAVQKAIPEYMTISQKH-VEVQIDKEAYLaVN 176
Cdd:pfam01991  81 AEKKLAELEEDTDEYKDLLRKLIVQALVKLGEPEVIVRCRKRDEELVESALDKAAEEYKAKTKKVtVEKAGDENDFL-ID 159
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 2462578315 177 AAGGVEVYSGNQRIKVSNTLESRLDLSAKQKMPEIRMALF 216
Cdd:pfam01991 160 CAGGVVLEGADGKIRVNNTLEARLDLVKEQLLPEIRKALF 199
 
Name Accession Description Interval E-value
vATP-synt_E pfam01991
ATP synthase (E/31 kDa) subunit; This family includes the vacuolar ATP synthase E subunit, as ...
18-216 1.05e-61

ATP synthase (E/31 kDa) subunit; This family includes the vacuolar ATP synthase E subunit, as well as the archaebacterial ATP synthase E subunit.


Pssm-ID: 396537 [Multi-domain]  Cd Length: 199  Bit Score: 191.44  E-value: 1.05e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462578315  18 FIEQEANEKAEEIDAKAEEEFNIEKGRLVQTQRLKIMEYYEKKEKQIEQQKKILMSTMRNQARLKVLRARNDLISDLLSE 97
Cdd:pfam01991   1 FIRQEAEEKAEEIRAKAEEEFAIEKAELVQEAEEKIDEIYEKKEKQAEMQKKIIISNAKNEARLKVLEAREEILDEVFNE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462578315  98 AKLRLSRIVEDPEVYQGLLDKLVLQGLLRLLEPVMIVRCRPQDLLLVEAAVQKAIPEYMTISQKH-VEVQIDKEAYLaVN 176
Cdd:pfam01991  81 AEKKLAELEEDTDEYKDLLRKLIVQALVKLGEPEVIVRCRKRDEELVESALDKAAEEYKAKTKKVtVEKAGDENDFL-ID 159
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 2462578315 177 AAGGVEVYSGNQRIKVSNTLESRLDLSAKQKMPEIRMALF 216
Cdd:pfam01991 160 CAGGVVLEGADGKIRVNNTLEARLDLVKEQLLPEIRKALF 199
NtpE COG1390
Archaeal/vacuolar-type H+-ATPase subunit E/Vma4 [Energy production and conversion]; Archaeal ...
19-217 6.83e-14

Archaeal/vacuolar-type H+-ATPase subunit E/Vma4 [Energy production and conversion]; Archaeal/vacuolar-type H+-ATPase subunit E/Vma4 is part of the Pathway/BioSystem: A/V-type ATP synthase


Pssm-ID: 441000 [Multi-domain]  Cd Length: 196  Bit Score: 67.66  E-value: 6.83e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462578315  19 IEQEANEKAEEIDAKAEEEFNIEKGRLVQTQRLKIMEYYEKKEKQIEQQKKILMSTMRNQARLKVLRARNDLISDLLSEA 98
Cdd:COG1390    11 ILEEAEAEAEEILEEAEEEAEKILEEAEEEAEEIKEEILEKAEREAEREKRRIISSAELEARKELLEAKEELIEEVFEEA 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462578315  99 KLRLSRIVEDPEvYQGLLDKLVLQGLLRLLEPVMIVRCRPQDLLLVEAAVQKAIPEYMTISQKHVEVqidkeaylavnaA 178
Cdd:COG1390    91 LEKLKNLPKDPE-YKELLKKLLKEAAEELGSGDLVVYVNEKDKELLEELLKELKKKGLEVSEEDIDI------------L 157
                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 2462578315 179 GGVEVYSGNQRIKVSNTLESRLDLSAKQKMPEIRMALFG 217
Cdd:COG1390   158 GGVIVESEDGRIRVDNTFESLLERLKEELLKEIAEILFG 196
PRK03963 PRK03963
V-type ATP synthase subunit E; Provisional
19-217 6.17e-05

V-type ATP synthase subunit E; Provisional


Pssm-ID: 167649 [Multi-domain]  Cd Length: 198  Bit Score: 42.44  E-value: 6.17e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462578315  19 IEQEANEKAEEIDAKAEEEFNIEKGRLVQTQRLKIMEYYEKKEKQIEQQKKILMSTMRNQARLKVLRARNDLISDLLSEA 98
Cdd:PRK03963   11 INREAEQKIEYILEEAQKEAEKIKEEARKRAESKAEWILRKAKTQAELEKQRIIANAKLEVRRKRLAVQEELISEVLEAV 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462578315  99 KLRLSRIVEDpEVYQGLLDKLVLQGLLRLLEPVmIVRCRPQDLLLVEAAVqkaipEYMTISQKHVEVQIDKeaylAVNAA 178
Cdd:PRK03963   91 RERLAELPED-EYFETLKALTKEAVEELGEDKV-VVRSNERTLKLIDSRL-----EEIRDELGDVEIELGE----PIETI 159
                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 2462578315 179 GGVEVYSGNQRIKVSNTLESRLDLSAKQKMPEIRMALFG 217
Cdd:PRK03963  160 GGVIVETKDGTIRVDNTFEARMERLESELRAKIAKALFG 198
 
Name Accession Description Interval E-value
vATP-synt_E pfam01991
ATP synthase (E/31 kDa) subunit; This family includes the vacuolar ATP synthase E subunit, as ...
18-216 1.05e-61

ATP synthase (E/31 kDa) subunit; This family includes the vacuolar ATP synthase E subunit, as well as the archaebacterial ATP synthase E subunit.


Pssm-ID: 396537 [Multi-domain]  Cd Length: 199  Bit Score: 191.44  E-value: 1.05e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462578315  18 FIEQEANEKAEEIDAKAEEEFNIEKGRLVQTQRLKIMEYYEKKEKQIEQQKKILMSTMRNQARLKVLRARNDLISDLLSE 97
Cdd:pfam01991   1 FIRQEAEEKAEEIRAKAEEEFAIEKAELVQEAEEKIDEIYEKKEKQAEMQKKIIISNAKNEARLKVLEAREEILDEVFNE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462578315  98 AKLRLSRIVEDPEVYQGLLDKLVLQGLLRLLEPVMIVRCRPQDLLLVEAAVQKAIPEYMTISQKH-VEVQIDKEAYLaVN 176
Cdd:pfam01991  81 AEKKLAELEEDTDEYKDLLRKLIVQALVKLGEPEVIVRCRKRDEELVESALDKAAEEYKAKTKKVtVEKAGDENDFL-ID 159
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 2462578315 177 AAGGVEVYSGNQRIKVSNTLESRLDLSAKQKMPEIRMALF 216
Cdd:pfam01991 160 CAGGVVLEGADGKIRVNNTLEARLDLVKEQLLPEIRKALF 199
NtpE COG1390
Archaeal/vacuolar-type H+-ATPase subunit E/Vma4 [Energy production and conversion]; Archaeal ...
19-217 6.83e-14

Archaeal/vacuolar-type H+-ATPase subunit E/Vma4 [Energy production and conversion]; Archaeal/vacuolar-type H+-ATPase subunit E/Vma4 is part of the Pathway/BioSystem: A/V-type ATP synthase


Pssm-ID: 441000 [Multi-domain]  Cd Length: 196  Bit Score: 67.66  E-value: 6.83e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462578315  19 IEQEANEKAEEIDAKAEEEFNIEKGRLVQTQRLKIMEYYEKKEKQIEQQKKILMSTMRNQARLKVLRARNDLISDLLSEA 98
Cdd:COG1390    11 ILEEAEAEAEEILEEAEEEAEKILEEAEEEAEEIKEEILEKAEREAEREKRRIISSAELEARKELLEAKEELIEEVFEEA 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462578315  99 KLRLSRIVEDPEvYQGLLDKLVLQGLLRLLEPVMIVRCRPQDLLLVEAAVQKAIPEYMTISQKHVEVqidkeaylavnaA 178
Cdd:COG1390    91 LEKLKNLPKDPE-YKELLKKLLKEAAEELGSGDLVVYVNEKDKELLEELLKELKKKGLEVSEEDIDI------------L 157
                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 2462578315 179 GGVEVYSGNQRIKVSNTLESRLDLSAKQKMPEIRMALFG 217
Cdd:COG1390   158 GGVIVESEDGRIRVDNTFESLLERLKEELLKEIAEILFG 196
PRK03963 PRK03963
V-type ATP synthase subunit E; Provisional
19-217 6.17e-05

V-type ATP synthase subunit E; Provisional


Pssm-ID: 167649 [Multi-domain]  Cd Length: 198  Bit Score: 42.44  E-value: 6.17e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462578315  19 IEQEANEKAEEIDAKAEEEFNIEKGRLVQTQRLKIMEYYEKKEKQIEQQKKILMSTMRNQARLKVLRARNDLISDLLSEA 98
Cdd:PRK03963   11 INREAEQKIEYILEEAQKEAEKIKEEARKRAESKAEWILRKAKTQAELEKQRIIANAKLEVRRKRLAVQEELISEVLEAV 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462578315  99 KLRLSRIVEDpEVYQGLLDKLVLQGLLRLLEPVmIVRCRPQDLLLVEAAVqkaipEYMTISQKHVEVQIDKeaylAVNAA 178
Cdd:PRK03963   91 RERLAELPED-EYFETLKALTKEAVEELGEDKV-VVRSNERTLKLIDSRL-----EEIRDELGDVEIELGE----PIETI 159
                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 2462578315 179 GGVEVYSGNQRIKVSNTLESRLDLSAKQKMPEIRMALFG 217
Cdd:PRK03963  160 GGVIVETKDGTIRVDNTFEARMERLESELRAKIAKALFG 198
PRK02292 PRK02292
V-type ATP synthase subunit E; Provisional
1-217 8.88e-04

V-type ATP synthase subunit E; Provisional


Pssm-ID: 235026 [Multi-domain]  Cd Length: 188  Bit Score: 38.83  E-value: 8.88e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462578315   1 MALSDV--DVKKQIKHMMAFIEQEANEKAEEIDAKAEEEF-NIEKGRLvqtqrlkimeyyEKKEKQIEQQKKILMSTMRN 77
Cdd:PRK02292    1 MSLETVveDIRDEARARASEIRAEADEEAEEIIAEAEADAeEILEDRE------------AEAEREIEQLREQELSSAKL 68
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462578315  78 QARLKVLRARNDLISDLLSEAKLRLSRIVED--PEVYQGLLDKLVLqgllrllePVMIVRCRPQDLLLVEAavqkaipey 155
Cdd:PRK02292   69 EAKRERLNARKEVLEDVRNQVEDEIASLDGDkrEELTKSLLDAADA--------DGVRVYSRKDDEDLVKS--------- 131
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462578315 156 mtISQKHVEVQIDKEaylaVNAAGGVEVYSGNQRIKVSNTLESRLDLSAKQKMPEIRMALFG 217
Cdd:PRK02292  132 --LLSDYDGLEYAGN----IDCLGGVVVESEDGRVRVNNTFDSILEDVWEDNLKEISDRLFG 187
PRK12704 PRK12704
phosphodiesterase; Provisional
9-105 3.02e-03

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 38.22  E-value: 3.02e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462578315   9 KKQIKHMMAFIEQEANEKAEEIDAKAEEEFNIEKGRLVQT-QRLKI--------MEYYEKKEKQIEQQKKILmstmrnQA 79
Cdd:PRK12704   48 KKEAEAIKKEALLEAKEEIHKLRNEFEKELRERRNELQKLeKRLLQkeenldrkLELLEKREEELEKKEKEL------EQ 121
                          90       100
                  ....*....|....*....|....*.
gi 2462578315  80 RLKVLRARNDLISDLLSEAKLRLSRI 105
Cdd:PRK12704  122 KQQELEKKEEELEELIEEQLQELERI 147
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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