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Conserved domains on  [gi|2462589040|ref|XP_054202126|]
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vesicle-trafficking protein SEC22a isoform X1 [Homo sapiens]

Protein Classification

longin domain-containing protein( domain architecture ID 13000475)

longin domain-containing protein such as synaptobrevin family proteins, Arabidopsis thaliana phytolongin and mammalian vesicle-trafficking protein SEC2, which are involved in membrane-trafficking and vesicle transport, respectively

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Longin cd14824
longin domain; Longin-domain is N-terminal domain of a subgroup of R-SNARE proteins, including ...
 5-126 5.64e-32

longin domain; Longin-domain is N-terminal domain of a subgroup of R-SNARE proteins, including VAMP7, Ykt6, and Sec22. Longin is one of the approximately 26 components required for transporting proteins from the ER to the plasma membrane, via the Golgi apparatus. It is necessary for the steps of the transfer from the ER to the Golgi complex. Longins are the only R-SNAREs that are common to all eukaryotes, and they are characterized by a conserved N-terminal domain with a profilin-like fold called a longin domain.


:

Pssm-ID: 341428  Cd Length: 122  Bit Score: 115.05  E-value: 5.64e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462589040   5 LSASVIRVRDGLPLSASTDYEQ-STGMQECRKYFKMLSRKLAQLPDRCTLKTGHYNINFISSLGVSYMMLCTENYPNVLA 83
Cdd:cd14824     1 LYALIARGSDGLILAEYTDLSSfSSVKENFKFVAKTILERTPPSGQRQSVEEGDYVFHYLVEDGLCYLCITDKEYPKRVA 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 2462589040  84 FSFLDELQKEFITTYNMMKTnTAVRPYCFIEFDNFIQRTKQRY 126
Cdd:cd14824    81 FAFLEEVLDEFLSKYGSSAW-TAARPYLFSEFDPELKKLMKKY 122
 
Name Accession Description Interval E-value
Longin cd14824
longin domain; Longin-domain is N-terminal domain of a subgroup of R-SNARE proteins, including ...
 5-126 5.64e-32

longin domain; Longin-domain is N-terminal domain of a subgroup of R-SNARE proteins, including VAMP7, Ykt6, and Sec22. Longin is one of the approximately 26 components required for transporting proteins from the ER to the plasma membrane, via the Golgi apparatus. It is necessary for the steps of the transfer from the ER to the Golgi complex. Longins are the only R-SNAREs that are common to all eukaryotes, and they are characterized by a conserved N-terminal domain with a profilin-like fold called a longin domain.


Pssm-ID: 341428  Cd Length: 122  Bit Score: 115.05  E-value: 5.64e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462589040   5 LSASVIRVRDGLPLSASTDYEQ-STGMQECRKYFKMLSRKLAQLPDRCTLKTGHYNINFISSLGVSYMMLCTENYPNVLA 83
Cdd:cd14824     1 LYALIARGSDGLILAEYTDLSSfSSVKENFKFVAKTILERTPPSGQRQSVEEGDYVFHYLVEDGLCYLCITDKEYPKRVA 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 2462589040  84 FSFLDELQKEFITTYNMMKTnTAVRPYCFIEFDNFIQRTKQRY 126
Cdd:cd14824    81 FAFLEEVLDEFLSKYGSSAW-TAARPYLFSEFDPELKKLMKKY 122
Longin pfam13774
Regulated-SNARE-like domain; Longin is one of the approximately 26 components required for ...
 38-117 1.65e-20

Regulated-SNARE-like domain; Longin is one of the approximately 26 components required for transporting proteins from the ER to the plasma membrane, via the Golgi apparatus. It is necessary for the steps of the transfer from the ER to the Golgi complex. Longins are the only R-SNAREs that are common to all eukaryotes, and they are characterized by a conserved N-terminal domain with a profilin-like fold called a longin domain.


Pssm-ID: 463978  Cd Length: 81  Bit Score: 83.74  E-value: 1.65e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462589040  38 KMLSRKLAQLPDRCTLKTGHYNINFISSLGVSYMMLCTENYPNVLAFSFLDELQKEFITTYNMMkTNTAVRPYCFI-EFD 116
Cdd:pfam13774   2 KTILEKIPQNPQRQTYEGDNYTFHYLIEDGLTYLVIADKSYPRRLAFAFLEEIKDEFLSTYGPW-TASALRPYAFNkEFD 80


                  .
gi 2462589040 117 N 117
Cdd:pfam13774  81 T 81
SNC1 COG5143
Synaptobrevin/VAMP-like protein [Intracellular trafficking and secretion];
4-146 4.20e-07

Synaptobrevin/VAMP-like protein [Intracellular trafficking and secretion];


Pssm-ID: 227472 [Multi-domain]  Cd Length: 190  Bit Score: 49.35  E-value: 4.20e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462589040   4 ILSASVIRVrDGLPLSASTD-YEQSTGMQECRKYFKMLSRKLA-QLPDRCTLKTGHYNIN-FISSLGVSYMMLCTENYPN 80
Cdd:COG5143     1 IASISLFRV-KGEPLRTLSDaESLSSFSFFHRSKVKEVLRFLSkTSASRASIESGDYFFHyLKMSSGIVYVPISDKEYPN 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462589040  81 VLAFSFLDELQKEFITTYNMMKTNTAVRPYCFIEFDNFIQRtkqRYNNPRSlstKINLSDMQTEIK 146
Cdd:COG5143    80 KLAYGYLNSIATEFLKSSALEQLIDDTVGIMRVNIDKVIEK---GYRDPSI---QDKLDQLQQELE 139
 
Name Accession Description Interval E-value
Longin cd14824
longin domain; Longin-domain is N-terminal domain of a subgroup of R-SNARE proteins, including ...
 5-126 5.64e-32

longin domain; Longin-domain is N-terminal domain of a subgroup of R-SNARE proteins, including VAMP7, Ykt6, and Sec22. Longin is one of the approximately 26 components required for transporting proteins from the ER to the plasma membrane, via the Golgi apparatus. It is necessary for the steps of the transfer from the ER to the Golgi complex. Longins are the only R-SNAREs that are common to all eukaryotes, and they are characterized by a conserved N-terminal domain with a profilin-like fold called a longin domain.


Pssm-ID: 341428  Cd Length: 122  Bit Score: 115.05  E-value: 5.64e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462589040   5 LSASVIRVRDGLPLSASTDYEQ-STGMQECRKYFKMLSRKLAQLPDRCTLKTGHYNINFISSLGVSYMMLCTENYPNVLA 83
Cdd:cd14824     1 LYALIARGSDGLILAEYTDLSSfSSVKENFKFVAKTILERTPPSGQRQSVEEGDYVFHYLVEDGLCYLCITDKEYPKRVA 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 2462589040  84 FSFLDELQKEFITTYNMMKTnTAVRPYCFIEFDNFIQRTKQRY 126
Cdd:cd14824    81 FAFLEEVLDEFLSKYGSSAW-TAARPYLFSEFDPELKKLMKKY 122
Longin pfam13774
Regulated-SNARE-like domain; Longin is one of the approximately 26 components required for ...
 38-117 1.65e-20

Regulated-SNARE-like domain; Longin is one of the approximately 26 components required for transporting proteins from the ER to the plasma membrane, via the Golgi apparatus. It is necessary for the steps of the transfer from the ER to the Golgi complex. Longins are the only R-SNAREs that are common to all eukaryotes, and they are characterized by a conserved N-terminal domain with a profilin-like fold called a longin domain.


Pssm-ID: 463978  Cd Length: 81  Bit Score: 83.74  E-value: 1.65e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462589040  38 KMLSRKLAQLPDRCTLKTGHYNINFISSLGVSYMMLCTENYPNVLAFSFLDELQKEFITTYNMMkTNTAVRPYCFI-EFD 116
Cdd:pfam13774   2 KTILEKIPQNPQRQTYEGDNYTFHYLIEDGLTYLVIADKSYPRRLAFAFLEEIKDEFLSTYGPW-TASALRPYAFNkEFD 80


                  .
gi 2462589040 117 N 117
Cdd:pfam13774  81 T 81
longin-like cd14818
Longin-like domains; Longin-like domains are small protein domains present in a variety of ...
 7-122 9.98e-12

Longin-like domains; Longin-like domains are small protein domains present in a variety of proteins and members of protein complexes involved in or required for different steps during the transport of proteins from the ribosome to the ER to the plasma membrane, via the Golgi apparatus. Examples are mu and sigma subunits of the heterotetrameric adaptor protein (AP) complex, zeta and delta subunits of the heterotetrameric F-COPI complex, a subgroup of R-SNARE proteins, a subfamily of the transport protein particle (TRAPP), and the signal recognition particle receptor subunit alpha (SR-alpha).


Pssm-ID: 341426  Cd Length: 117  Bit Score: 61.00  E-value: 9.98e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462589040   7 ASVIRVRDGLPLSASTDYEQSTGMQECRKYFKMLSRKLAQL-PDRCTLKTGHYNINFISSLGVSYMMLCTENYPNVLAFS 85
Cdd:cd14818     2 QLAVFDPQGQVLAASNWLGKKPSVKFSLIQIKSFFSKLITSgFDFLTLTIGSYTFHYYLNKGLYFVVITDEQELRQELFQ 81

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2462589040  86 FLDELQKEFITTYnMMKTNTAVRPYCFIEFDNFIQRT 122
Cdd:cd14818    82 TLNLLLKEFNSLH-GSEVITKNIEDDLEEFESYLDIK 117
SNC1 COG5143
Synaptobrevin/VAMP-like protein [Intracellular trafficking and secretion];
4-146 4.20e-07

Synaptobrevin/VAMP-like protein [Intracellular trafficking and secretion];


Pssm-ID: 227472 [Multi-domain]  Cd Length: 190  Bit Score: 49.35  E-value: 4.20e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462589040   4 ILSASVIRVrDGLPLSASTD-YEQSTGMQECRKYFKMLSRKLA-QLPDRCTLKTGHYNIN-FISSLGVSYMMLCTENYPN 80
Cdd:COG5143     1 IASISLFRV-KGEPLRTLSDaESLSSFSFFHRSKVKEVLRFLSkTSASRASIESGDYFFHyLKMSSGIVYVPISDKEYPN 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462589040  81 VLAFSFLDELQKEFITTYNMMKTNTAVRPYCFIEFDNFIQRtkqRYNNPRSlstKINLSDMQTEIK 146
Cdd:COG5143    80 KLAYGYLNSIATEFLKSSALEQLIDDTVGIMRVNIDKVIEK---GYRDPSI---QDKLDQLQQELE 139
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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