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Conserved domains on  [gi|2462594550|ref|XP_054204733|]
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protein transport protein Sec24B isoform X10 [Homo sapiens]

Protein Classification

SEC24 family transport protein( domain architecture ID 1001573)

SEC24 family transport protein is a component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5028 super family cl34873
Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking ...
 367-1163 0e+00

Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion];


The actual alignment was detected with superfamily member COG5028:

Pssm-ID: 227361 [Multi-domain]  Cd Length: 861  Bit Score: 567.88  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594550  367 YPTLQPGYQNATAPLISGVQPSNpvysgfQQYPQQYPGVNqLSSSIGGLSLQSSP------QPESLRPVNLTQERNILPM 440
Cdd:COG5028     64 TAMHNTGANNPAPSVMSPAFQSQ------QKFSSPYGGSM-ADGTAPKPTNPLVPvdlfedQPPPISDLFLPPPPIVPPL 136

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594550  441 TPVWAPVpnlnadlKKLNCSPDSFRCTLTNIPQTQALLNKAKLPLGLLLHPFRDLT----QLPVITSNTIVRCRSCRTYI 516
Cdd:COG5028    137 TTNFVGS-------EQSNCSPKYVRSTMYAIPETNDLLKKSKIPFGLVIRPFLELYpeedPVPLVEDGSIVRCRRCRSYI 209

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594550  517 NPFVSFIDQ-RRWKCNLCYRVNDVPEEFmYNPLTRS--YGEPHKRPEVQNSTVEFIASSDYMLRPPQPAVYLFVLDVSHN 593
Cdd:COG5028    210 NPFVQFIEQgRKWRCNICRSKNDVPEGF-DNPSGPNdpRSDRYSRPELKSGVVDFLAPKEYSLRQPPPPVYVFLIDVSFE 288

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594550  594 AVEAGYLTILCQSLLENLDKLPG-DSRTRIGFMTFDSTIHFYNLQEGLSQpQMLIVSDIDDVFLPTP-DSLLVNLYESKE 671
Cdd:COG5028    289 AIKNGLVKAAIRAILENLDQIPNfDPRTKIAIICFDSSLHFFKLSPDLDE-QMLIVSDLDEPFLPFPsGLFVLPLKSCKQ 367

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594550  672 LIKDLLNALPNMFTNTRETHSALGPALQAAFKLMSPTGGRVSVFQTQLPSLGAGLLQSREDPNQRsstkvvqHLGPATDF 751
Cdd:COG5028    368 IIETLLDRVPRIFQDNKSPKNALGPALKAAKSLIGGTGGKIIVFLSTLPNMGIGKLQLREDKESS-------LLSCKDSF 440

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594550  752 YKKLALDCSGQQTAVDLFLLSSQYSDLASLACMSKYSAGCIYYYPSFHYThNPSQAEKLQKDLKRYLTRKIGFEAVMRIR 831
Cdd:COG5028    441 YKEFAIECSKVGISVDLFLTSEDYIDVATLSHLCRYTGGQTYFYPNFSAT-RPNDATKLANDLVSHLSMEIGYEAVMRVR 519

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594550  832 CTKGLSMHTFHGNFFVRSTDLLSLANINPDAGFAVQLSIEESLTdTSLVCFQTALLYTSSKGERRIRVHTLCLPVVSSLA 911
Cdd:COG5028    520 CSTGLRVSSFYGNFFNRSSDLCAFSTMPRDTSLLVEFSIDEKLM-TSDVYFQVALLYTLNDGERRIRVVNLSLPTSSSIR 598

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594550  912 DVYAGVDVQAAICLLANMAVDRSVSSSLSDARDALVNAVVDSLSAY-GSTVSNLQHSALMAPSSLKLFPLYVLALLKQKA 990
Cdd:COG5028    599 EVYASADQLAIACILAKKASTKALNSSLKEARVLINKSMVDILKAYkKELVKSNTSTQLPLPANLKLLPLLMLALLKSSA 678

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594550  991 FRTGtSTRLDDRVYAMCQIKSQPLVHLMKMIHPNLYRIDRLTDEGAVHVNDRIVPQPPLqKLSAEKLTREGAFLMDCGSV 1070
Cdd:COG5028    679 FRSG-STPSDIRISALNRLTSLPLKQLMRNIYPTLYALHDMPIEAGLPDEGLLVLPSPI-NATSSLLESGGLYLIDTGQK 756

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594550 1071 FYIWVGKGCDNNFIEDVLGYTNFASIPQKMTHLPELDTLSSERARSFITWLRDSRP-LSPILHIVKD--ESPAKAEFFQH 1147
Cdd:COG5028    757 IFLWFGKDAVPSLLQDLFGVDSLSDIPSGKFTLPPTGNEFNERVRNIIGELRSVNDdSTLPLVLVRGggDPSLRLWFFST 836

                          810
                   ....*....|....*.
gi 2462594550 1148 LIEDRTEAAFSYYEFL 1163
Cdd:COG5028    837 LVEDKTLNIPSYLDYL 852
 
Name Accession Description Interval E-value
COG5028 COG5028
Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking ...
 367-1163 0e+00

Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion];


Pssm-ID: 227361 [Multi-domain]  Cd Length: 861  Bit Score: 567.88  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594550  367 YPTLQPGYQNATAPLISGVQPSNpvysgfQQYPQQYPGVNqLSSSIGGLSLQSSP------QPESLRPVNLTQERNILPM 440
Cdd:COG5028     64 TAMHNTGANNPAPSVMSPAFQSQ------QKFSSPYGGSM-ADGTAPKPTNPLVPvdlfedQPPPISDLFLPPPPIVPPL 136

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594550  441 TPVWAPVpnlnadlKKLNCSPDSFRCTLTNIPQTQALLNKAKLPLGLLLHPFRDLT----QLPVITSNTIVRCRSCRTYI 516
Cdd:COG5028    137 TTNFVGS-------EQSNCSPKYVRSTMYAIPETNDLLKKSKIPFGLVIRPFLELYpeedPVPLVEDGSIVRCRRCRSYI 209

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594550  517 NPFVSFIDQ-RRWKCNLCYRVNDVPEEFmYNPLTRS--YGEPHKRPEVQNSTVEFIASSDYMLRPPQPAVYLFVLDVSHN 593
Cdd:COG5028    210 NPFVQFIEQgRKWRCNICRSKNDVPEGF-DNPSGPNdpRSDRYSRPELKSGVVDFLAPKEYSLRQPPPPVYVFLIDVSFE 288

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594550  594 AVEAGYLTILCQSLLENLDKLPG-DSRTRIGFMTFDSTIHFYNLQEGLSQpQMLIVSDIDDVFLPTP-DSLLVNLYESKE 671
Cdd:COG5028    289 AIKNGLVKAAIRAILENLDQIPNfDPRTKIAIICFDSSLHFFKLSPDLDE-QMLIVSDLDEPFLPFPsGLFVLPLKSCKQ 367

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594550  672 LIKDLLNALPNMFTNTRETHSALGPALQAAFKLMSPTGGRVSVFQTQLPSLGAGLLQSREDPNQRsstkvvqHLGPATDF 751
Cdd:COG5028    368 IIETLLDRVPRIFQDNKSPKNALGPALKAAKSLIGGTGGKIIVFLSTLPNMGIGKLQLREDKESS-------LLSCKDSF 440

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594550  752 YKKLALDCSGQQTAVDLFLLSSQYSDLASLACMSKYSAGCIYYYPSFHYThNPSQAEKLQKDLKRYLTRKIGFEAVMRIR 831
Cdd:COG5028    441 YKEFAIECSKVGISVDLFLTSEDYIDVATLSHLCRYTGGQTYFYPNFSAT-RPNDATKLANDLVSHLSMEIGYEAVMRVR 519

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594550  832 CTKGLSMHTFHGNFFVRSTDLLSLANINPDAGFAVQLSIEESLTdTSLVCFQTALLYTSSKGERRIRVHTLCLPVVSSLA 911
Cdd:COG5028    520 CSTGLRVSSFYGNFFNRSSDLCAFSTMPRDTSLLVEFSIDEKLM-TSDVYFQVALLYTLNDGERRIRVVNLSLPTSSSIR 598

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594550  912 DVYAGVDVQAAICLLANMAVDRSVSSSLSDARDALVNAVVDSLSAY-GSTVSNLQHSALMAPSSLKLFPLYVLALLKQKA 990
Cdd:COG5028    599 EVYASADQLAIACILAKKASTKALNSSLKEARVLINKSMVDILKAYkKELVKSNTSTQLPLPANLKLLPLLMLALLKSSA 678

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594550  991 FRTGtSTRLDDRVYAMCQIKSQPLVHLMKMIHPNLYRIDRLTDEGAVHVNDRIVPQPPLqKLSAEKLTREGAFLMDCGSV 1070
Cdd:COG5028    679 FRSG-STPSDIRISALNRLTSLPLKQLMRNIYPTLYALHDMPIEAGLPDEGLLVLPSPI-NATSSLLESGGLYLIDTGQK 756

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594550 1071 FYIWVGKGCDNNFIEDVLGYTNFASIPQKMTHLPELDTLSSERARSFITWLRDSRP-LSPILHIVKD--ESPAKAEFFQH 1147
Cdd:COG5028    757 IFLWFGKDAVPSLLQDLFGVDSLSDIPSGKFTLPPTGNEFNERVRNIIGELRSVNDdSTLPLVLVRGggDPSLRLWFFST 836

                          810
                   ....*....|....*.
gi 2462594550 1148 LIEDRTEAAFSYYEFL 1163
Cdd:COG5028    837 LVEDKTLNIPSYLDYL 852
Sec24-like cd01479
Sec24-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the ...
 579-822 2.54e-132

Sec24-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the budding and fusion of intracellular transport vesicles that selectively carry cargo proteins and lipids from donor to acceptor organelles. The two main classes of vesicular carriers within the endocytic and the biosynthetic pathways are COP- and clathrin-coated vesicles. Formation of COPII vesicles requires the ordered assembly of the coat built from several cytosolic components GTPase Sar1, complexes of Sec23-Sec24 and Sec13-Sec31. The process is initiated by the conversion of GDP to GTP by the GTPase Sar1 which then recruits the heterodimeric complex of Sec23 and Sec24. This heterodimeric complex generates the pre-budding complex. The final step leading to membrane deformation and budding of COPII-coated vesicles is carried by the heterodimeric complex Sec13-Sec31. The members of this CD belong to the Sec23-like family. Sec 24 is very similar to Sec23. The Sec23 and Sec24 polypeptides fold into five distinct domains: a beta-barrel, a zinc finger, a vWA or trunk, an all helical region and a carboxy Gelsolin domain. The members of this subgroup carry a partial MIDAS motif and have the overall Para-Rossmann type fold that is characteristic of this superfamily.


Pssm-ID: 238756 [Multi-domain]  Cd Length: 244  Bit Score: 402.81  E-value: 2.54e-132
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594550  579 PQPAVYLFVLDVSHNAVEAGYLTILCQSLLENLDKLPGD-SRTRIGFMTFDSTIHFYNLQEGLSQPQMLIVSDIDDVFLP 657
Cdd:cd01479      1 PQPAVYVFLIDVSYNAIKSGLLATACEALLSNLDNLPGDdPRTRVGFITFDSTLHFFNLKSSLEQPQMMVVSDLDDPFLP 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594550  658 TPDSLLVNLYESKELIKDLLNALPNMFTNTRETHSALGPALQAAFKLMSPTGGRVSVFQTQLPSLGAGLLQSREDPNQRS 737
Cdd:cd01479     81 LPDGLLVNLKESRQVIEDLLDQIPEMFQDTKETESALGPALQAAFLLLKETGGKIIVFQSSLPTLGAGKLKSREDPKLLS 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594550  738 STKVVQHLGPATDFYKKLALDCSGQQTAVDLFLLSSQYSDLASLACMSKYSAGCIYYYPSFHyTHNPSQAEKLQKDLKRY 817
Cdd:cd01479    161 TDKEKQLLQPQTDFYKKLALECVKSQISVDLFLFSNQYVDVATLGCLSRLTGGQVYYYPSFN-FSAPNDVEKLVNELARY 239


                   ....*
gi 2462594550  818 LTRKI 822
Cdd:cd01479    240 LTRKI 244
Sec23_trunk pfam04811
Sec23/Sec24 trunk domain; COPII-coated vesicles carry proteins from the endoplasmic reticulum ...
 579-818 3.21e-108

Sec23/Sec24 trunk domain; COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi complex. This vesicular transport can be reconstituted by using three cytosolic components containing five proteins: the small GTPase Sar1p, the Sec23p/24p complex, and the Sec13p/Sec31p complex. This domain is known as the trunk domain and has an alpha/beta vWA fold and forms the dimer interface.


Pssm-ID: 398467 [Multi-domain]  Cd Length: 241  Bit Score: 338.84  E-value: 3.21e-108
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594550  579 PQPAVYLFVLDVSHNAVEAGYLTILCQSLLENLDKLPGDSRTRIGFMTFDSTIHFYNLQEGLSQPQMLIVSDIDDVFLPT 658
Cdd:pfam04811    1 PQPPVFLFVIDVSYNAIKSGLLAALKESLLQSLDLLPGDPRARVGFITFDSTVHFFNLGSSLRQPQMLVVSDLQDMFLPL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594550  659 PDSLLVNLYESKELIKDLLNALPNMFTNTRETHSALGPALQAAFKLM--SPTGGRVSVFQTQLPSLGA-GLLQSREDPNQ 735
Cdd:pfam04811   81 PDRFLVPLSECRFVLEDLLEQLPPMFPVTKRPERCLGPALQAAFLLLkaAFTGGKIMVFQGGLPTVGPgGKLKSRLDESH 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594550  736 RSSTKVVQHLGPATD-FYKKLALDCSGQQTAVDLFLLSSQYSDLASLACMSKYSAGCIYYYPSFHYTHnpsQAEKLQKDL 814
Cdd:pfam04811  161 HGTDKEKAKLVKKADkFYKSLAKECVKQGHSVDLFAFSLDYVDVATLGQLSRLTGGQVYLYPSFQADV---DGSKFKQDL 237


                   ....
gi 2462594550  815 KRYL 818
Cdd:pfam04811  238 QRYF 241
PTZ00395 PTZ00395
Sec24-related protein; Provisional
 544-1172 2.79e-44

Sec24-related protein; Provisional


Pssm-ID: 185594 [Multi-domain]  Cd Length: 1560  Bit Score: 176.03  E-value: 2.79e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594550  544 MYNPLTRSYGEPHKRPEVQNStvefiassdYMLRPPQ-----PAVYLFVLDVSHNAVEAGYLTILCQSL---LENLdKLP 615
Cdd:PTZ00395   919 MKNLICEKNGEPDSAKIRRNS---------FLAKYPQvknmlPPYFVFVVECSYNAIYNNITYTILEGIryaVQNV-KCP 988

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594550  616 gdsRTRIGFMTFDSTIHFYNLQEGLSQP-------------QMLIVSDIDDVFLPTP-DSLLVNLYESKELIKDLLNALP 681
Cdd:PTZ00395   989 ---QTKIAIITFNSSIYFYHCKGGKGVSgeegdggggsgnhQVIVMSDVDDPFLPLPlEDLFFGCVEEIDKINTLIDTIK 1065

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594550  682 NMFTNTRETHSALGPALQAAFKLMSPTGG--RVSVFQTQLPSLGAGLLQSREDPNQRSSTKVVQHLgpatdFYKKLALDC 759
Cdd:PTZ00395  1066 SVSTTMQSYGSCGNSALKIAMDMLKERNGlgSICMFYTTTPNCGIGAIKELKKDLQENFLEVKQKI-----FYDSLLLDL 1140

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594550  760 SGQQTAVDLFLLSSQYSDLA--SLACMSKYSAGCIYYYPSFHYthnpsqaeklQKDLKR-YL-------TRKIGFEAVMR 829
Cdd:PTZ00395  1141 YAFNISVDIFIISSNNVRVCvpSLQYVAQNTGGKILFVENFLW----------QKDYKEiYMnimdtltSEDIAYCCELK 1210

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594550  830 IRCTKGLSMHTF---HGNF-FVRSTDLLSLANINPDAGFAVQLSIEESLTDTSLVCFQTALLYTSSKGERRIRVHTLCLP 905
Cdd:PTZ00395  1211 LRYSHHMSVKKLfccNNNFnSIISVDTIKIPKIRHDQTFAFLLNYSDISESKKQIYFQCACIYTNLWGDRFVRLHTTHMN 1290

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594550  906 VVSSLADVYAGVDVQAaiclLANMAVDRSVSSSLSDarDALVNAVVDSLSA----YGSTVSNLQHSA-LMAPSSLKLFPL 980
Cdd:PTZ00395  1291 LTSSLSTVFRYTDAEA----LMNILIKQLCTNILHN--DNYSKIIIDNLAAilfsYRINCASSAHSGqLILPDTLKLLPL 1364

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594550  981 YVLALLKQKAfrTGTSTRLDDRVYAMCQIKSQPLVHLMKMIHPNLY--RIDRLTDE-GAVHVNDRIVpQPPLQKLSAEKL 1057
Cdd:PTZ00395  1365 FTSSLLKHNV--TKKEILHDLKVYSLIKLLSMPIISSLLYVYPVMYviHIKGKTNEiDSMDVDDDLF-IPKTIPSSAEKI 1441

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594550 1058 TREGAFLMDCGSVFYIWVGKGCDNNFIEDVLGytnfaSIP-QKMTHLPEL-DTLSSERARSFItwlrdsRPLSPILH--- 1132
Cdd:PTZ00395  1442 YSNGIYLLDACTHFYLYFGFHSDANFAKEIVG-----DIPtEKNAHELNLtDTPNAQKVQRII------KNLSRIHHfnk 1510

                          650       660       670       680
                   ....*....|....*....|....*....|....*....|....*
gi 2462594550 1133 -----IVKDESPAKAEFFQHLIEDRTEAAFSYYEFLLHVQQQICK 1172
Cdd:PTZ00395  1511 yvplvMVAPKSNEEEHLISLCVEDKADKEYSYVNFLCFIHKLVHK 1555
GEL smart00262
Gelsolin homology domain; Gelsolin/severin/villin homology domain. Calcium-binding and ...
 1037-1079 9.03e-03

Gelsolin homology domain; Gelsolin/severin/villin homology domain. Calcium-binding and actin-binding. Both intra- and extracellular domains.


Pssm-ID: 214590 [Multi-domain]  Cd Length: 90  Bit Score: 36.50  E-value: 9.03e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 2462594550  1037 VHVNDRIVPQPPLQKLSAEKLTREGAFLMDCGSVFYIWVGKGC 1079
Cdd:smart00262    3 VRVKGKRNVRVPEVPFSQGSLNSGDCYILDTGSEIYVWVGKKS 45
 
Name Accession Description Interval E-value
COG5028 COG5028
Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking ...
 367-1163 0e+00

Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion];


Pssm-ID: 227361 [Multi-domain]  Cd Length: 861  Bit Score: 567.88  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594550  367 YPTLQPGYQNATAPLISGVQPSNpvysgfQQYPQQYPGVNqLSSSIGGLSLQSSP------QPESLRPVNLTQERNILPM 440
Cdd:COG5028     64 TAMHNTGANNPAPSVMSPAFQSQ------QKFSSPYGGSM-ADGTAPKPTNPLVPvdlfedQPPPISDLFLPPPPIVPPL 136

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594550  441 TPVWAPVpnlnadlKKLNCSPDSFRCTLTNIPQTQALLNKAKLPLGLLLHPFRDLT----QLPVITSNTIVRCRSCRTYI 516
Cdd:COG5028    137 TTNFVGS-------EQSNCSPKYVRSTMYAIPETNDLLKKSKIPFGLVIRPFLELYpeedPVPLVEDGSIVRCRRCRSYI 209

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594550  517 NPFVSFIDQ-RRWKCNLCYRVNDVPEEFmYNPLTRS--YGEPHKRPEVQNSTVEFIASSDYMLRPPQPAVYLFVLDVSHN 593
Cdd:COG5028    210 NPFVQFIEQgRKWRCNICRSKNDVPEGF-DNPSGPNdpRSDRYSRPELKSGVVDFLAPKEYSLRQPPPPVYVFLIDVSFE 288

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594550  594 AVEAGYLTILCQSLLENLDKLPG-DSRTRIGFMTFDSTIHFYNLQEGLSQpQMLIVSDIDDVFLPTP-DSLLVNLYESKE 671
Cdd:COG5028    289 AIKNGLVKAAIRAILENLDQIPNfDPRTKIAIICFDSSLHFFKLSPDLDE-QMLIVSDLDEPFLPFPsGLFVLPLKSCKQ 367

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594550  672 LIKDLLNALPNMFTNTRETHSALGPALQAAFKLMSPTGGRVSVFQTQLPSLGAGLLQSREDPNQRsstkvvqHLGPATDF 751
Cdd:COG5028    368 IIETLLDRVPRIFQDNKSPKNALGPALKAAKSLIGGTGGKIIVFLSTLPNMGIGKLQLREDKESS-------LLSCKDSF 440

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594550  752 YKKLALDCSGQQTAVDLFLLSSQYSDLASLACMSKYSAGCIYYYPSFHYThNPSQAEKLQKDLKRYLTRKIGFEAVMRIR 831
Cdd:COG5028    441 YKEFAIECSKVGISVDLFLTSEDYIDVATLSHLCRYTGGQTYFYPNFSAT-RPNDATKLANDLVSHLSMEIGYEAVMRVR 519

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594550  832 CTKGLSMHTFHGNFFVRSTDLLSLANINPDAGFAVQLSIEESLTdTSLVCFQTALLYTSSKGERRIRVHTLCLPVVSSLA 911
Cdd:COG5028    520 CSTGLRVSSFYGNFFNRSSDLCAFSTMPRDTSLLVEFSIDEKLM-TSDVYFQVALLYTLNDGERRIRVVNLSLPTSSSIR 598

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594550  912 DVYAGVDVQAAICLLANMAVDRSVSSSLSDARDALVNAVVDSLSAY-GSTVSNLQHSALMAPSSLKLFPLYVLALLKQKA 990
Cdd:COG5028    599 EVYASADQLAIACILAKKASTKALNSSLKEARVLINKSMVDILKAYkKELVKSNTSTQLPLPANLKLLPLLMLALLKSSA 678

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594550  991 FRTGtSTRLDDRVYAMCQIKSQPLVHLMKMIHPNLYRIDRLTDEGAVHVNDRIVPQPPLqKLSAEKLTREGAFLMDCGSV 1070
Cdd:COG5028    679 FRSG-STPSDIRISALNRLTSLPLKQLMRNIYPTLYALHDMPIEAGLPDEGLLVLPSPI-NATSSLLESGGLYLIDTGQK 756

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594550 1071 FYIWVGKGCDNNFIEDVLGYTNFASIPQKMTHLPELDTLSSERARSFITWLRDSRP-LSPILHIVKD--ESPAKAEFFQH 1147
Cdd:COG5028    757 IFLWFGKDAVPSLLQDLFGVDSLSDIPSGKFTLPPTGNEFNERVRNIIGELRSVNDdSTLPLVLVRGggDPSLRLWFFST 836

                          810
                   ....*....|....*.
gi 2462594550 1148 LIEDRTEAAFSYYEFL 1163
Cdd:COG5028    837 LVEDKTLNIPSYLDYL 852
Sec24-like cd01479
Sec24-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the ...
 579-822 2.54e-132

Sec24-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the budding and fusion of intracellular transport vesicles that selectively carry cargo proteins and lipids from donor to acceptor organelles. The two main classes of vesicular carriers within the endocytic and the biosynthetic pathways are COP- and clathrin-coated vesicles. Formation of COPII vesicles requires the ordered assembly of the coat built from several cytosolic components GTPase Sar1, complexes of Sec23-Sec24 and Sec13-Sec31. The process is initiated by the conversion of GDP to GTP by the GTPase Sar1 which then recruits the heterodimeric complex of Sec23 and Sec24. This heterodimeric complex generates the pre-budding complex. The final step leading to membrane deformation and budding of COPII-coated vesicles is carried by the heterodimeric complex Sec13-Sec31. The members of this CD belong to the Sec23-like family. Sec 24 is very similar to Sec23. The Sec23 and Sec24 polypeptides fold into five distinct domains: a beta-barrel, a zinc finger, a vWA or trunk, an all helical region and a carboxy Gelsolin domain. The members of this subgroup carry a partial MIDAS motif and have the overall Para-Rossmann type fold that is characteristic of this superfamily.


Pssm-ID: 238756 [Multi-domain]  Cd Length: 244  Bit Score: 402.81  E-value: 2.54e-132
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594550  579 PQPAVYLFVLDVSHNAVEAGYLTILCQSLLENLDKLPGD-SRTRIGFMTFDSTIHFYNLQEGLSQPQMLIVSDIDDVFLP 657
Cdd:cd01479      1 PQPAVYVFLIDVSYNAIKSGLLATACEALLSNLDNLPGDdPRTRVGFITFDSTLHFFNLKSSLEQPQMMVVSDLDDPFLP 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594550  658 TPDSLLVNLYESKELIKDLLNALPNMFTNTRETHSALGPALQAAFKLMSPTGGRVSVFQTQLPSLGAGLLQSREDPNQRS 737
Cdd:cd01479     81 LPDGLLVNLKESRQVIEDLLDQIPEMFQDTKETESALGPALQAAFLLLKETGGKIIVFQSSLPTLGAGKLKSREDPKLLS 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594550  738 STKVVQHLGPATDFYKKLALDCSGQQTAVDLFLLSSQYSDLASLACMSKYSAGCIYYYPSFHyTHNPSQAEKLQKDLKRY 817
Cdd:cd01479    161 TDKEKQLLQPQTDFYKKLALECVKSQISVDLFLFSNQYVDVATLGCLSRLTGGQVYYYPSFN-FSAPNDVEKLVNELARY 239


                   ....*
gi 2462594550  818 LTRKI 822
Cdd:cd01479    240 LTRKI 244
Sec23_trunk pfam04811
Sec23/Sec24 trunk domain; COPII-coated vesicles carry proteins from the endoplasmic reticulum ...
 579-818 3.21e-108

Sec23/Sec24 trunk domain; COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi complex. This vesicular transport can be reconstituted by using three cytosolic components containing five proteins: the small GTPase Sar1p, the Sec23p/24p complex, and the Sec13p/Sec31p complex. This domain is known as the trunk domain and has an alpha/beta vWA fold and forms the dimer interface.


Pssm-ID: 398467 [Multi-domain]  Cd Length: 241  Bit Score: 338.84  E-value: 3.21e-108
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594550  579 PQPAVYLFVLDVSHNAVEAGYLTILCQSLLENLDKLPGDSRTRIGFMTFDSTIHFYNLQEGLSQPQMLIVSDIDDVFLPT 658
Cdd:pfam04811    1 PQPPVFLFVIDVSYNAIKSGLLAALKESLLQSLDLLPGDPRARVGFITFDSTVHFFNLGSSLRQPQMLVVSDLQDMFLPL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594550  659 PDSLLVNLYESKELIKDLLNALPNMFTNTRETHSALGPALQAAFKLM--SPTGGRVSVFQTQLPSLGA-GLLQSREDPNQ 735
Cdd:pfam04811   81 PDRFLVPLSECRFVLEDLLEQLPPMFPVTKRPERCLGPALQAAFLLLkaAFTGGKIMVFQGGLPTVGPgGKLKSRLDESH 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594550  736 RSSTKVVQHLGPATD-FYKKLALDCSGQQTAVDLFLLSSQYSDLASLACMSKYSAGCIYYYPSFHYTHnpsQAEKLQKDL 814
Cdd:pfam04811  161 HGTDKEKAKLVKKADkFYKSLAKECVKQGHSVDLFAFSLDYVDVATLGQLSRLTGGQVYLYPSFQADV---DGSKFKQDL 237


                   ....
gi 2462594550  815 KRYL 818
Cdd:pfam04811  238 QRYF 241
trunk_domain cd01468
trunk domain. COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi ...
 579-816 1.50e-105

trunk domain. COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi complex. This vesicular transport can be reconstituted by using three cytosolic components containing five proteins: the small GTPase Sar1p, the Sec23p/24p complex, and the Sec13p/Sec31p complex. This domain is known as the trunk domain and has an alpha/beta vWA fold and forms the dimer interface. Some members of this family possess a partial MIDAS motif that is a characteristic feature of most vWA domain proteins.


Pssm-ID: 238745 [Multi-domain]  Cd Length: 239  Bit Score: 331.52  E-value: 1.50e-105
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594550  579 PQPAVYLFVLDVSHNAVEAGYLTILCQSLLENLDKLPGDSRTRIGFMTFDSTIHFYNLQEGLSQPQMLIVSDIDDVFLPT 658
Cdd:cd01468      1 PQPPVFVFVIDVSYEAIKEGLLQALKESLLASLDLLPGDPRARVGLITYDSTVHFYNLSSDLAQPKMYVVSDLKDVFLPL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594550  659 PDSLLVNLYESKELIKDLLNALPNMFTN--TRETHSALGPALQAAFKLMSPT--GGRVSVFQTQLPSLGAGLLQSREDPN 734
Cdd:cd01468     81 PDRFLVPLSECKKVIHDLLEQLPPMFWPvpTHRPERCLGPALQAAFLLLKGTfaGGRIIVFQGGLPTVGPGKLKSREDKE 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594550  735 QRSSTKVVQHLGPATDFYKKLALDCSGQQTAVDLFLLSSQYSDLASLACMSKYSAGCIYYYPSFHYthnPSQAEKLQKDL 814
Cdd:cd01468    161 PIRSHDEAQLLKPATKFYKSLAKECVKSGICVDLFAFSLDYVDVATLKQLAKSTGGQVYLYDSFQA---PNDGSKFKQDL 237


                   ..
gi 2462594550  815 KR 816
Cdd:cd01468    238 QR 239
PTZ00395 PTZ00395
Sec24-related protein; Provisional
 544-1172 2.79e-44

Sec24-related protein; Provisional


Pssm-ID: 185594 [Multi-domain]  Cd Length: 1560  Bit Score: 176.03  E-value: 2.79e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594550  544 MYNPLTRSYGEPHKRPEVQNStvefiassdYMLRPPQ-----PAVYLFVLDVSHNAVEAGYLTILCQSL---LENLdKLP 615
Cdd:PTZ00395   919 MKNLICEKNGEPDSAKIRRNS---------FLAKYPQvknmlPPYFVFVVECSYNAIYNNITYTILEGIryaVQNV-KCP 988

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594550  616 gdsRTRIGFMTFDSTIHFYNLQEGLSQP-------------QMLIVSDIDDVFLPTP-DSLLVNLYESKELIKDLLNALP 681
Cdd:PTZ00395   989 ---QTKIAIITFNSSIYFYHCKGGKGVSgeegdggggsgnhQVIVMSDVDDPFLPLPlEDLFFGCVEEIDKINTLIDTIK 1065

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594550  682 NMFTNTRETHSALGPALQAAFKLMSPTGG--RVSVFQTQLPSLGAGLLQSREDPNQRSSTKVVQHLgpatdFYKKLALDC 759
Cdd:PTZ00395  1066 SVSTTMQSYGSCGNSALKIAMDMLKERNGlgSICMFYTTTPNCGIGAIKELKKDLQENFLEVKQKI-----FYDSLLLDL 1140

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594550  760 SGQQTAVDLFLLSSQYSDLA--SLACMSKYSAGCIYYYPSFHYthnpsqaeklQKDLKR-YL-------TRKIGFEAVMR 829
Cdd:PTZ00395  1141 YAFNISVDIFIISSNNVRVCvpSLQYVAQNTGGKILFVENFLW----------QKDYKEiYMnimdtltSEDIAYCCELK 1210

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594550  830 IRCTKGLSMHTF---HGNF-FVRSTDLLSLANINPDAGFAVQLSIEESLTDTSLVCFQTALLYTSSKGERRIRVHTLCLP 905
Cdd:PTZ00395  1211 LRYSHHMSVKKLfccNNNFnSIISVDTIKIPKIRHDQTFAFLLNYSDISESKKQIYFQCACIYTNLWGDRFVRLHTTHMN 1290

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594550  906 VVSSLADVYAGVDVQAaiclLANMAVDRSVSSSLSDarDALVNAVVDSLSA----YGSTVSNLQHSA-LMAPSSLKLFPL 980
Cdd:PTZ00395  1291 LTSSLSTVFRYTDAEA----LMNILIKQLCTNILHN--DNYSKIIIDNLAAilfsYRINCASSAHSGqLILPDTLKLLPL 1364

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594550  981 YVLALLKQKAfrTGTSTRLDDRVYAMCQIKSQPLVHLMKMIHPNLY--RIDRLTDE-GAVHVNDRIVpQPPLQKLSAEKL 1057
Cdd:PTZ00395  1365 FTSSLLKHNV--TKKEILHDLKVYSLIKLLSMPIISSLLYVYPVMYviHIKGKTNEiDSMDVDDDLF-IPKTIPSSAEKI 1441

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594550 1058 TREGAFLMDCGSVFYIWVGKGCDNNFIEDVLGytnfaSIP-QKMTHLPEL-DTLSSERARSFItwlrdsRPLSPILH--- 1132
Cdd:PTZ00395  1442 YSNGIYLLDACTHFYLYFGFHSDANFAKEIVG-----DIPtEKNAHELNLtDTPNAQKVQRII------KNLSRIHHfnk 1510

                          650       660       670       680
                   ....*....|....*....|....*....|....*....|....*
gi 2462594550 1133 -----IVKDESPAKAEFFQHLIEDRTEAAFSYYEFLLHVQQQICK 1172
Cdd:PTZ00395  1511 yvplvMVAPKSNEEEHLISLCVEDKADKEYSYVNFLCFIHKLVHK 1555
Sec23_helical pfam04815
Sec23/Sec24 helical domain; COPII-coated vesicles carry proteins from the endoplasmic ...
 918-1019 2.58e-34

Sec23/Sec24 helical domain; COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi complex. This vesicular transport can be reconstituted by using three cytosolic components containing five proteins: the small GTPase Sar1p, the Sec23p/24p complex, and the Sec13p/Sec31p complex. This domain is composed of five alpha helices.


Pssm-ID: 461441 [Multi-domain]  Cd Length: 103  Bit Score: 126.85  E-value: 2.58e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594550  918 DVQAAICLLANMAVDRSVSSSLSDARDALVNAVVDSLSAYGSTVSNLQHSA-LMAPSSLKLFPLYVLALLKQKAFRTGTS 996
Cdd:pfam04815    1 DQEAIAVLLAKKAVEKALSSSLSDAREALDNKLVDILAAYRKYCASSSSPGqLILPESLKLLPLYMLALLKSPALRGGNS 80

                           90       100
                   ....*....|....*....|...
gi 2462594550  997 TRLDDRVYAMCQIKSQPLVHLMK 1019
Cdd:pfam04815   81 SPSDERAYARHLLLSLPVEELLL 103
Sec23_BS pfam08033
Sec23/Sec24 beta-sandwich domain;
823-907 2.41e-32

Sec23/Sec24 beta-sandwich domain;


Pssm-ID: 429794 [Multi-domain]  Cd Length: 86  Bit Score: 120.72  E-value: 2.41e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594550  823 GFEAVMRIRCTKGLSMHTFHGNFFVRS-TDLLSLANINPDAGFAVQLSIEESLTDTSLVCFQTALLYTSSKGERRIRVHT 901
Cdd:pfam08033    1 GFNAVLRVRTSKGLKVSGFIGNFVSRSsGDTWKLPSLDPDTSYAFEFDIDEPLPNGSNAYIQFALLYTHSSGERRIRVTT 80


                   ....*.
gi 2462594550  902 LCLPVV 907
Cdd:pfam08033   81 VALPVT 86
SEC23 COG5047
Vesicle coat complex COPII, subunit SEC23 [Intracellular trafficking and secretion];
462-1078 2.66e-22

Vesicle coat complex COPII, subunit SEC23 [Intracellular trafficking and secretion];


Pssm-ID: 227380 [Multi-domain]  Cd Length: 755  Bit Score: 103.42  E-value: 2.66e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594550  462 DSFRCTLTNIPQTQALLNKAKLPLGLLLHPFRDLTQLPVITSNTIVRCRSCRTYINPFVSfIDQRR--WKCNLCYRVNDV 539
Cdd:COG5047     10 DGIRLTWNVFPATRGDATRTVIPIACLYTPLHEDDALTVNYYEPVKCTAPCKAVLNPYCH-IDERNqsWICPFCNQRNTL 88

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594550  540 PEEfmYNPLTRSYGEPhkRPEVQNSTVEFIASsdymlRPPQ-PAVYLFVLDVshnAVEAGYLTILCQSLLENLDKLPGDS 618
Cdd:COG5047     89 PPQ--YRDISNANLPL--ELLPQSSTIEYTLS-----KPVIlPPVFFFVVDA---CCDEEELTALKDSLIVSLSLLPPEA 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594550  619 rtRIGFMTFDSTIHF----------------------YNLQE--GLSQPQMLIV--SDIDDVFLPTPDSLLVNLYESKEL 672
Cdd:COG5047    157 --LVGLITYGTSIQVhelnaenhrrsyvfsgnkeytkENLQEllALSKPTKSGGfeSKISGIGQFASSRFLLPTQQCEFK 234

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594550  673 IKDLLNAL-------PNMFTNTRETHSALGPA---LQAAFKLMsptGGRVSVFQTQLPSLGAGLLQSRE--DP---NQRS 737
Cdd:COG5047    235 LLNILEQLqpdpwpvPAGKRPLRCTGSALNIAsslLEQCFPNA---GCHIVLFAGGPCTVGPGTVVSTElkEPmrsHHDI 311

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594550  738 STKVVQHLGPATDFYKKLALDCSGQQTAVDLFLLSSQYSDLASLACMSKYSAGCIYYYPSFhythnpsQAEKLQKDLKRY 817
Cdd:COG5047    312 ESDSAQHSKKATKFYKGLAERVANQGHALDIFAGCLDQIGIMEMEPLTTSTGGALVLSDSF-------TTSIFKQSFQRI 384

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594550  818 LTR------KIGFEAVMRIRCTKGLSMHTFHGN---------------FFVRSTDLLSLANINPDAGFAVQLSIEESLTD 876
Cdd:COG5047    385 FNRdsegylKMGFNANMEVKTSKNLKIKGLIGHavsvkkkannisdseIGIGATNSWKMASLSPKSNYALYFEIALGAAS 464

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594550  877 TS-------LVCFQTalLYTSSKGERRIRVHTLCLPVVSSLADV-YAGVDVQAAICLLANMAVDRSVSSSLSDArDALVN 948
Cdd:COG5047    465 GSaqrpaeaYIQFIT--TYQHSSGTYRIRVTTVARMFTDGGLPKiNRSFDQEAAAVFMARIAAFKAETEDIIDV-FRWID 541

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594550  949 AVVDSLSAYGSTVSNLQHSALMAPSSLKLFPLYVLALLKQKAFRTGtSTRLDDRVYAMCQIKSQPLVHLMKMIHPNLYRI 1028
Cdd:COG5047    542 RNLIRLCQKFADYRKDDPSSFRLDPNFTLYPQFMYHLRRSPFLSVF-NNSPDETAFYRHMLNNADVNDSLIMIQPTLQSY 620

                          650       660       670       680       690
                   ....*....|....*....|....*....|....*....|....*....|
gi 2462594550 1029 DRLTDEGAVHVnDRIVPQPPLQKLSAEKLTregaFLMDCGSVFYIWVGKG 1078
Cdd:COG5047    621 SFEKGGVPVLL-DSVSVKPDVILLLDTFFH----ILIFHGSYIAQWRNAG 665
zf-Sec23_Sec24 pfam04810
Sec23/Sec24 zinc finger; COPII-coated vesicles carry proteins from the endoplasmic reticulum ...
 506-542 4.96e-16

Sec23/Sec24 zinc finger; COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi complex. This vesicular transport can be reconstituted by using three cytosolic components containing five proteins: the small GTPase Sar1p, the Sec23p/24p complex, and the Sec13p/Sec31p complex. This domain is found to be zinc binding domain.


Pssm-ID: 461437 [Multi-domain]  Cd Length: 38  Bit Score: 72.48  E-value: 4.96e-16
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2462594550  506 IVRCRSCRTYINPFVSFIDQ-RRWKCNLCYRVNDVPEE 542
Cdd:pfam04810    1 PVRCRRCRAYLNPFCQFDFGgKKWTCNFCGTRNPVPPE 38
PLN00162 PLN00162
transport protein sec23; Provisional
 462-946 5.08e-14

transport protein sec23; Provisional


Pssm-ID: 215083 [Multi-domain]  Cd Length: 761  Bit Score: 76.90  E-value: 5.08e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594550  462 DSFRCTLTNIPQTQALLNKAKLPLGLLLHPFRDLTQLPVITSNTIvRCRSCRTYINPF--VSFiDQRRWKCNLCYRVNDV 539
Cdd:PLN00162    10 DGVRMSWNVWPSSKIEASKCVIPLAALYTPLKPLPELPVLPYDPL-RCRTCRAVLNPYcrVDF-QAKIWICPFCFQRNHF 87

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594550  540 PeefmynpltRSY---GEPHKRPEV--QNSTVEFiASSDYMLRPPQPAVYLFVLDVSHNAVEAGYLTilcQSLLENLDKL 614
Cdd:PLN00162    88 P---------PHYssiSETNLPAELfpQYTTVEY-TLPPGSGGAPSPPVFVFVVDTCMIEEELGALK---SALLQAIALL 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594550  615 PGDSrtRIGFMTFDSTIHFYNL------------------------QEGLS----QPQMLIVSDIDDVFLPTP-DSLLVN 665
Cdd:PLN00162   155 PENA--LVGLITFGTHVHVHELgfsecsksyvfrgnkevskdqileQLGLGgkkrRPAGGGIAGARDGLSSSGvNRFLLP 232

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594550  666 LYESKELIKDLLNALPNMFTNTRETHSAL---GPALQAAFKLM---SP-TGGRVSVFqTQLPS-LGAGLLQSREDPNQRS 737
Cdd:PLN00162   233 ASECEFTLNSALEELQKDPWPVPPGHRPArctGAALSVAAGLLgacVPgTGARIMAF-VGGPCtEGPGAIVSKDLSEPIR 311

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594550  738 STK-----VVQHLGPATDFYKKLALDCSGQQTAVDLFLLSSQYSDLASLACMSKYSAGCIYYYPSFHythnpsqAEKLQK 812
Cdd:PLN00162   312 SHKdldkdAAPYYKKAVKFYEGLAKQLVAQGHVLDVFACSLDQVGVAEMKVAVERTGGLVVLAESFG-------HSVFKD 384

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594550  813 DLKRYLTR------KIGFEAVMRIRCTKGL----------SMH----------TFHGNffvrsTDLLSLANINPDAGFAV 866
Cdd:PLN00162   385 SLRRVFERdgegslGLSFNGTFEVNCSKDVkvqgaigpcaSLEkkgpsvsdteIGEGG-----TTAWKLCGLDKKTSLAV 459

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594550  867 --QLSIEESLTDTSL---VCFQTALLYTSSKGERRIRVHTLCLPVV--SSLADVYAGVDVQAAICLLANMAVDRSVSssl 939
Cdd:PLN00162   460 ffEVANSGQSNPQPPgqqFFLQFLTRYQHSNGQTRLRVTTVTRRWVegSSSEELVAGFDQEAAAVVMARLASHKMET--- 536


                   ....*..
gi 2462594550  940 SDARDAL 946
Cdd:PLN00162   537 EEEFDAT 543
Gelsolin pfam00626
Gelsolin repeat;
1044-1118 2.95e-11

Gelsolin repeat;


Pssm-ID: 395501 [Multi-domain]  Cd Length: 76  Bit Score: 60.40  E-value: 2.95e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462594550 1044 VPQPPLQKLSAEKLTREGAFLMDCGSVFYIWVGKGcdNNFIEDVLGYTNFASIP-QKMTHLPELDTLS-SERARSFI 1118
Cdd:pfam00626    2 FVLPPPVPLSQESLNSGDCYLLDNGFTIFLWVGKG--SSLLEKLFAALLAAQLDdDERFPLPEVIRVPqGKEPARFL 76
GEL smart00262
Gelsolin homology domain; Gelsolin/severin/villin homology domain. Calcium-binding and ...
 1037-1079 9.03e-03

Gelsolin homology domain; Gelsolin/severin/villin homology domain. Calcium-binding and actin-binding. Both intra- and extracellular domains.


Pssm-ID: 214590 [Multi-domain]  Cd Length: 90  Bit Score: 36.50  E-value: 9.03e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 2462594550  1037 VHVNDRIVPQPPLQKLSAEKLTREGAFLMDCGSVFYIWVGKGC 1079
Cdd:smart00262    3 VRVKGKRNVRVPEVPFSQGSLNSGDCYILDTGSEIYVWVGKKS 45
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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