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Conserved domains on  [gi|2462594713|ref|XP_054204812|]
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annexin A10 isoform X1 [Homo sapiens]

Protein Classification

annexin( domain architecture ID 10446041)

annexin belongs to a family of calcium- and phospholipid-binding proteins that have been implicated in many cellular processes, including channel formation, membrane fusion, vesicle transport, and regulation of phospholipase A2 activity

CATH:  1.10.220.10
Gene Ontology:  GO:0005509|GO:0005544|GO:0048306|GO:0003723
PubMed:  15059252|1646719
SCOP:  4001063
TCDB:  1.A.31

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 113-178 2.46e-24

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


:

Pssm-ID: 395139  Cd Length: 66  Bit Score: 94.08  E-value: 2.46e-24
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462594713 113 YDAHELWHAMKGVGTDENCLIEILASRTNGEIFQMREAYCLQYSNNLQEDIYSETSGHFRDTLMNL 178
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 271-336 6.84e-22

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


:

Pssm-ID: 395139  Cd Length: 66  Bit Score: 87.53  E-value: 6.84e-22
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462594713 271 YFAYRLYSAIHDFGFHNKTVIRILIARSEIDLLTIRKRYKERYGKSLFHDIRNFASGHYKKALLAI 336
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 195-261 4.32e-17

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


:

Pssm-ID: 395139  Cd Length: 66  Bit Score: 74.43  E-value: 4.32e-17
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462594713 195 QDAMVLWEACQqKTGEHKTMLQMILCNKSYQQLRLVFQEFQNISGQDMVDAINECYDGYFQELLVAI 261
Cdd:pfam00191   1 YDAELLRKAMK-GLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 22-65 3.23e-12

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


:

Pssm-ID: 395139  Cd Length: 66  Bit Score: 60.95  E-value: 3.23e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 2462594713  22 DAQMLGGALQGFDCDKDMLINILTQRCNAQRMMIAEAYQSMYGR 65
Cdd:pfam00191   2 DAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGK 45
 
Name Accession Description Interval E-value
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 113-178 2.46e-24

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 94.08  E-value: 2.46e-24
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462594713 113 YDAHELWHAMKGVGTDENCLIEILASRTNGEIFQMREAYCLQYSNNLQEDIYSETSGHFRDTLMNL 178
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 271-336 6.84e-22

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 87.53  E-value: 6.84e-22
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462594713 271 YFAYRLYSAIHDFGFHNKTVIRILIARSEIDLLTIRKRYKERYGKSLFHDIRNFASGHYKKALLAI 336
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 195-261 4.32e-17

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 74.43  E-value: 4.32e-17
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462594713 195 QDAMVLWEACQqKTGEHKTMLQMILCNKSYQQLRLVFQEFQNISGQDMVDAINECYDGYFQELLVAI 261
Cdd:pfam00191   1 YDAELLRKAMK-GLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
ANX smart00335
Annexin repeats;
288-336 3.08e-15

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 68.97  E-value: 3.08e-15
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 2462594713  288 KTVIRILIARSEIDLLTIRKRYKERYGKSLFHDIRNFASGHYKKALLAI 336
Cdd:smart00335   5 KTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
ANX smart00335
Annexin repeats;
126-178 1.44e-14

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 67.05  E-value: 1.44e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2462594713  126 GTDENCLIEILASRTNGEIFQMREAYCLQYSNNLQEDIYSETSGHFRDTLMNL 178
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 22-65 3.23e-12

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 60.95  E-value: 3.23e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 2462594713  22 DAQMLGGALQGFDCDKDMLINILTQRCNAQRMMIAEAYQSMYGR 65
Cdd:pfam00191   2 DAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGK 45
ANX smart00335
Annexin repeats;
218-261 1.58e-06

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 44.71  E-value: 1.58e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 2462594713  218 ILCNKSYQQLRLVFQEFQNISGQDMVDAIneCYD--GYFQELLVAI 261
Cdd:smart00335  10 ILASRSNAQLQAIKQAYKKRYGKDLEDDI--KSEtsGDFEKLLLAL 53
ANX smart00335
Annexin repeats;
36-65 1.87e-06

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 44.32  E-value: 1.87e-06
                           10        20        30
                   ....*....|....*....|....*....|
gi 2462594713   36 DKDMLINILTQRCNAQRMMIAEAYQSMYGR 65
Cdd:smart00335   3 DEKTLIEILASRSNAQLQAIKQAYKKRYGK 32
 
Name Accession Description Interval E-value
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 113-178 2.46e-24

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 94.08  E-value: 2.46e-24
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462594713 113 YDAHELWHAMKGVGTDENCLIEILASRTNGEIFQMREAYCLQYSNNLQEDIYSETSGHFRDTLMNL 178
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 271-336 6.84e-22

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 87.53  E-value: 6.84e-22
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462594713 271 YFAYRLYSAIHDFGFHNKTVIRILIARSEIDLLTIRKRYKERYGKSLFHDIRNFASGHYKKALLAI 336
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 195-261 4.32e-17

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 74.43  E-value: 4.32e-17
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462594713 195 QDAMVLWEACQqKTGEHKTMLQMILCNKSYQQLRLVFQEFQNISGQDMVDAINECYDGYFQELLVAI 261
Cdd:pfam00191   1 YDAELLRKAMK-GLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
ANX smart00335
Annexin repeats;
288-336 3.08e-15

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 68.97  E-value: 3.08e-15
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 2462594713  288 KTVIRILIARSEIDLLTIRKRYKERYGKSLFHDIRNFASGHYKKALLAI 336
Cdd:smart00335   5 KTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
ANX smart00335
Annexin repeats;
126-178 1.44e-14

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 67.05  E-value: 1.44e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2462594713  126 GTDENCLIEILASRTNGEIFQMREAYCLQYSNNLQEDIYSETSGHFRDTLMNL 178
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 22-65 3.23e-12

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 60.95  E-value: 3.23e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 2462594713  22 DAQMLGGALQGFDCDKDMLINILTQRCNAQRMMIAEAYQSMYGR 65
Cdd:pfam00191   2 DAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGK 45
ANX smart00335
Annexin repeats;
218-261 1.58e-06

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 44.71  E-value: 1.58e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 2462594713  218 ILCNKSYQQLRLVFQEFQNISGQDMVDAIneCYD--GYFQELLVAI 261
Cdd:smart00335  10 ILASRSNAQLQAIKQAYKKRYGKDLEDDI--KSEtsGDFEKLLLAL 53
ANX smart00335
Annexin repeats;
36-65 1.87e-06

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 44.32  E-value: 1.87e-06
                           10        20        30
                   ....*....|....*....|....*....|
gi 2462594713   36 DKDMLINILTQRCNAQRMMIAEAYQSMYGR 65
Cdd:smart00335   3 DEKTLIEILASRSNAQLQAIKQAYKKRYGK 32
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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