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Conserved domains on  [gi|2462598394|ref|XP_054206571|]
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kelch-like protein 8 isoform X2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
128-382 1.55e-54

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 182.66  E-value: 1.55e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462598394 128 TPRKHTAGVLfcVGGR----GG--SGDPFRSIECYSINKNSWFFGPEMNSRRR-HVGVISVEGKVYAVGGHDGN----EH 196
Cdd:COG3055    11 TPRSEAAAAL--LDGKvyvaGGlsGGSASNSFEVYDPATNTWSELAPLPGPPRhHAAAVAQDGKLYVFGGFTGAnpssTP 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462598394 197 LGSMEMFDPLTNKWMMKASMNTKRRGIALASLGGPIYAIGGLDDNTCFNDVERYDIESDQWSTVAPMNTPRGGVGSVALV 276
Cdd:COG3055    89 LNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLPTPRDHLAAAVLP 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462598394 277 N-HVYAVGGNDGmaslssveryDPHLDKWIEVKEMGQRRAGNGVSKLHGCLYVVGGfdDNSPLSSVERYDPRSNKWDYVA 355
Cdd:COG3055   169 DgKILVIGGRNG----------SGFSNTWTTLAPLPTARAGHAAAVLGGKILVFGG--ESGFSDEVEAYDPATNTWTALG 236

                         250       260
                  ....*....|....*....|....*..
gi 2462598394 356 ALTTPRGGVGIATVMGKIFAVGGHNGN 382
Cdd:COG3055   237 ELPTPRHGHAAVLTDGKVYVIGGETKP 263
Kelch smart00612
Kelch domain;
372-416 9.60e-12

Kelch domain;


:

Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 59.49  E-value: 9.60e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 2462598394  372 KIFAVGGHNGNAYLNTVEAFDPVLNRWELVGSVSHCRAGAGVAVC 416
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVI 45
BACK super family cl28903
BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal ...
 73-111 1.20e-08

BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal to a BTB domain, in a diverse set of architectures together with Kelch, MATH, and/or TAZ domains. It is involved in interactions with the Cullin3 (Cul3) ubiquitin ligase complex, as well as in homo-oligomerization. Most proteins containing the BACK domain are understood to function as adaptor proteins that play a role in ubiquitination of various substrates.


The actual alignment was detected with superfamily member cd18452:

Pssm-ID: 475122 [Multi-domain]  Cd Length: 136  Bit Score: 53.56  E-value: 1.20e-08
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2462598394  73 VRLPLLPVDFLMGVVAKEQIVKQNLKCRDLLDEARNYHL 111
Cdd:cd18452    93 VRLPLLSPRYITDVVDAEPLIRCSLECRDLVDEAKKFHL 131
BTB_POZ super family cl38908
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 52-73 2.62e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.


The actual alignment was detected with superfamily member cd18238:

Pssm-ID: 453885 [Multi-domain]  Cd Length: 120  Bit Score: 43.43  E-value: 2.62e-05
                          10        20
                  ....*....|....*....|..
gi 2462598394  52 DFHGSLLRFYENGELCDVTLKV 73
Cdd:cd18238     1 DSFKVLHQFYENGELCDVTLKV 22
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
128-382 1.55e-54

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 182.66  E-value: 1.55e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462598394 128 TPRKHTAGVLfcVGGR----GG--SGDPFRSIECYSINKNSWFFGPEMNSRRR-HVGVISVEGKVYAVGGHDGN----EH 196
Cdd:COG3055    11 TPRSEAAAAL--LDGKvyvaGGlsGGSASNSFEVYDPATNTWSELAPLPGPPRhHAAAVAQDGKLYVFGGFTGAnpssTP 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462598394 197 LGSMEMFDPLTNKWMMKASMNTKRRGIALASLGGPIYAIGGLDDNTCFNDVERYDIESDQWSTVAPMNTPRGGVGSVALV 276
Cdd:COG3055    89 LNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLPTPRDHLAAAVLP 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462598394 277 N-HVYAVGGNDGmaslssveryDPHLDKWIEVKEMGQRRAGNGVSKLHGCLYVVGGfdDNSPLSSVERYDPRSNKWDYVA 355
Cdd:COG3055   169 DgKILVIGGRNG----------SGFSNTWTTLAPLPTARAGHAAAVLGGKILVFGG--ESGFSDEVEAYDPATNTWTALG 236

                         250       260
                  ....*....|....*....|....*..
gi 2462598394 356 ALTTPRGGVGIATVMGKIFAVGGHNGN 382
Cdd:COG3055   237 ELPTPRHGHAAVLTDGKVYVIGGETKP 263
PHA03098 PHA03098
kelch-like protein; Provisional
 136-352 2.02e-41

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 154.16  E-value: 2.02e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462598394 136 VLFCVGGRGGSGDPFRSIECYSINKNSWFFGPEMNSRRRHVGVISVEGKVYAVGGHDGNEHLGSMEMFDPLTNKWMMKAS 215
Cdd:PHA03098  296 VIYFIGGMNKNNLSVNSVVSYDTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGIYNSISLNTVESWKPGESKWREEPP 375

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462598394 216 MNTKRRGIALASLGGPIYAIGGLDDN-TCFNDVERYDIESDQWSTVAPMNTPRGGVGSVALVNHVYAVGG---NDGMASL 291
Cdd:PHA03098  376 LIFPRYNPCVVNVNNLIYVIGGISKNdELLKTVECFSLNTNKWSKGSPLPISHYGGCAIYHDGKIYVIGGisyIDNIKVY 455

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462598394 292 SSVERYDPHLDKWIEVKEMGQRRAGNGVSKLHGCLYVVGGFDDNSPLSSVERYDPRSNKWD 352
Cdd:PHA03098  456 NIVESYNPVTNKWTELSSLNFPRINASLCIFNNKIYVVGGDKYEYYINEIEVYDDKTNTWT 516
Kelch smart00612
Kelch domain;
325-371 3.52e-13

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 63.73  E-value: 3.52e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 2462598394  325 CLYVVGGFDDNSPLSSVERYDPRSNKWDYVAALTTPRGGVGIATVMG 371
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
Kelch smart00612
Kelch domain;
372-416 9.60e-12

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 59.49  E-value: 9.60e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 2462598394  372 KIFAVGGHNGNAYLNTVEAFDPVLNRWELVGSVSHCRAGAGVAVC 416
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVI 45
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 172-217 1.10e-11

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 59.16  E-value: 1.10e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 2462598394 172 RRRHVGVISVEGKVYAVGGHDGNEHLGSMEMFDPLTNKWMMKASMN 217
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46
BACK_KLHL12 cd18452
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also ...
 73-111 1.20e-08

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also termed CUL3-interacting protein 1 (C3IP1), or DKIR, is a substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport.


Pssm-ID: 350527 [Multi-domain]  Cd Length: 136  Bit Score: 53.56  E-value: 1.20e-08
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2462598394  73 VRLPLLPVDFLMGVVAKEQIVKQNLKCRDLLDEARNYHL 111
Cdd:cd18452    93 VRLPLLSPRYITDVVDAEPLIRCSLECRDLVDEAKKFHL 131
BTB_POZ_KLHL8 cd18238
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 52-73 2.62e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349547 [Multi-domain]  Cd Length: 120  Bit Score: 43.43  E-value: 2.62e-05
                          10        20
                  ....*....|....*....|..
gi 2462598394  52 DFHGSLLRFYENGELCDVTLKV 73
Cdd:cd18238     1 DSFKVLHQFYENGELCDVTLKV 22
muta_rot_YjhT TIGR03547
mutatrotase, YjhT family; Members of this protein family contain multiple copies of the ...
 267-393 1.38e-04

mutatrotase, YjhT family; Members of this protein family contain multiple copies of the beta-propeller-forming Kelch repeat. All are full-length homologs to YjhT of Escherichia coli, which has been identified as a mutarotase for sialic acid. This protein improves bacterial ability to obtain host sialic acid, and thus serves as a virulence factor. Some bacteria carry what appears to be a cyclically permuted homolog of this protein.


Pssm-ID: 274641 [Multi-domain]  Cd Length: 346  Bit Score: 43.85  E-value: 1.38e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462598394 267 RGGVGsvALVNHVYAVGGNDGMASLSSVERYDPHlDKWIEVKEM-GQRRAGNGVSKLHGCLYVVGGF----DDNSP--LS 339
Cdd:TIGR03547   9 KNGTG--AIIGDKVYVGLGSAGTSWYKLDLKKPS-KGWQKIADFpGGPRNQAVAAAIDGKLYVFGGIgkanSEGSPqvFD 85

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462598394 340 SVERYDPRSNKWDYVAAlTTPRGGVGIATVM---GKIFAVGGHNG---NAYLNTVEAFDP 393
Cdd:TIGR03547  86 DVYRYDPKKNSWQKLDT-RSPVGLLGASGFSlhnGQAYFTGGVNKnifDGYFADLSAADK 144
Kelch_6 pfam13964
Kelch motif;
360-408 7.83e-03

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 34.23  E-value: 7.83e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 2462598394 360 PRGGVGIATVMGKIFAVGG-HNGNAYLNTVEAFDPVLNRWELVGSVSHCR 408
Cdd:pfam13964   1 PRTFHSVVSVGGYIYVFGGyTNASPALNKLEVYNPLTKSWEELPPLPTPR 50
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
128-382 1.55e-54

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 182.66  E-value: 1.55e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462598394 128 TPRKHTAGVLfcVGGR----GG--SGDPFRSIECYSINKNSWFFGPEMNSRRR-HVGVISVEGKVYAVGGHDGN----EH 196
Cdd:COG3055    11 TPRSEAAAAL--LDGKvyvaGGlsGGSASNSFEVYDPATNTWSELAPLPGPPRhHAAAVAQDGKLYVFGGFTGAnpssTP 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462598394 197 LGSMEMFDPLTNKWMMKASMNTKRRGIALASLGGPIYAIGGLDDNTCFNDVERYDIESDQWSTVAPMNTPRGGVGSVALV 276
Cdd:COG3055    89 LNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLPTPRDHLAAAVLP 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462598394 277 N-HVYAVGGNDGmaslssveryDPHLDKWIEVKEMGQRRAGNGVSKLHGCLYVVGGfdDNSPLSSVERYDPRSNKWDYVA 355
Cdd:COG3055   169 DgKILVIGGRNG----------SGFSNTWTTLAPLPTARAGHAAAVLGGKILVFGG--ESGFSDEVEAYDPATNTWTALG 236

                         250       260
                  ....*....|....*....|....*..
gi 2462598394 356 ALTTPRGGVGIATVMGKIFAVGGHNGN 382
Cdd:COG3055   237 ELPTPRHGHAAVLTDGKVYVIGGETKP 263
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
162-415 1.98e-54

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 182.28  E-value: 1.98e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462598394 162 SWFFGPEMNSRRRHVGVISVEGKVYAVGGHDGNEHLGSMEMFDPLTNKWMMKASMNTKRR-GIALASLGGPIYAIGGLDD 240
Cdd:COG3055     2 TWSSLPDLPTPRSEAAAALLDGKVYVAGGLSGGSASNSFEVYDPATNTWSELAPLPGPPRhHAAAVAQDGKLYVFGGFTG 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462598394 241 N----TCFNDVERYDIESDQWSTVAPMNTPRGGVGSVALVNHVYAVGGNDGMASLSSVERYDPHLDKWIEVKEMGQRRAG 316
Cdd:COG3055    82 AnpssTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLPTPRDH 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462598394 317 -NGVSKLHGCLYVVGGFDDNSPlssverydprSNKWDYVAALTTPRGGVGIATVMGKIFAVGGHNGnaYLNTVEAFDPVL 395
Cdd:COG3055   162 lAAAVLPDGKILVIGGRNGSGF----------SNTWTTLAPLPTARAGHAAAVLGGKILVFGGESG--FSDEVEAYDPAT 229

                         250       260
                  ....*....|....*....|
gi 2462598394 396 NRWELVGSVSHCRAGAGVAV 415
Cdd:COG3055   230 NTWTALGELPTPRHGHAAVL 249
PHA03098 PHA03098
kelch-like protein; Provisional
 136-352 2.02e-41

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 154.16  E-value: 2.02e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462598394 136 VLFCVGGRGGSGDPFRSIECYSINKNSWFFGPEMNSRRRHVGVISVEGKVYAVGGHDGNEHLGSMEMFDPLTNKWMMKAS 215
Cdd:PHA03098  296 VIYFIGGMNKNNLSVNSVVSYDTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGIYNSISLNTVESWKPGESKWREEPP 375

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462598394 216 MNTKRRGIALASLGGPIYAIGGLDDN-TCFNDVERYDIESDQWSTVAPMNTPRGGVGSVALVNHVYAVGG---NDGMASL 291
Cdd:PHA03098  376 LIFPRYNPCVVNVNNLIYVIGGISKNdELLKTVECFSLNTNKWSKGSPLPISHYGGCAIYHDGKIYVIGGisyIDNIKVY 455

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462598394 292 SSVERYDPHLDKWIEVKEMGQRRAGNGVSKLHGCLYVVGGFDDNSPLSSVERYDPRSNKWD 352
Cdd:PHA03098  456 NIVESYNPVTNKWTELSSLNFPRINASLCIFNNKIYVVGGDKYEYYINEIEVYDDKTNTWT 516
PHA03098 PHA03098
kelch-like protein; Provisional
 232-419 1.42e-29

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 120.64  E-value: 1.42e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462598394 232 IYAIGGLD-DNTCFNDVERYDIESDQWSTVAPMNTPRGGVGSVALVNHVYAVGGNDGMASLSSVERYDPHLDKWIEVKEM 310
Cdd:PHA03098  297 IYFIGGMNkNNLSVNSVVSYDTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGIYNSISLNTVESWKPGESKWREEPPL 376

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462598394 311 GQRRAGNGVSKLHGCLYVVGGFDDN-SPLSSVERYDPRSNKWDYVAALTTPRGGVGIATVMGKIFAVGGH---NGNAYLN 386
Cdd:PHA03098  377 IFPRYNPCVVNVNNLIYVIGGISKNdELLKTVECFSLNTNKWSKGSPLPISHYGGCAIYHDGKIYVIGGIsyiDNIKVYN 456

                         170       180       190
                  ....*....|....*....|....*....|...
gi 2462598394 387 TVEAFDPVLNRWELVGSVSHCRAGAGVAVCSCL 419
Cdd:PHA03098  457 IVESYNPVTNKWTELSSLNFPRINASLCIFNNK 489
PHA03098 PHA03098
kelch-like protein; Provisional
 217-398 1.27e-20

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 94.06  E-value: 1.27e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462598394 217 NTKRRGIALASLGGPIYaIGGLDDNTCFNDVERYDIESDQWSTVApmNTPRGGVGSVALVNHVYAVGG-NDGMASLSSVE 295
Cdd:PHA03098  238 NLNKILPRSSTFGSIIY-IHITMSIFTYNYITNYSPLSEINTIID--IHYVYCFGSVVLNNVIYFIGGmNKNNLSVNSVV 314

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462598394 296 RYDPHLDKWIEVKEMGQRRAGNGVSKLHGCLYVVGGFDDNSPLSSVERYDPRSNKWDYVAALTTPRGGVGIATVMGKIFA 375
Cdd:PHA03098  315 SYDTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGIYNSISLNTVESWKPGESKWREEPPLIFPRYNPCVVNVNNLIYV 394

                         170       180
                  ....*....|....*....|....
gi 2462598394 376 VGGHNGNAY-LNTVEAFDPVLNRW 398
Cdd:PHA03098  395 IGGISKNDElLKTVECFSLNTNKW 418
PHA03098 PHA03098
kelch-like protein; Provisional
 135-258 5.50e-19

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 89.06  E-value: 5.50e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462598394 135 GVLFCVGGRGGSGDPFRSIECYSINKNSWFFGPEMNSRRRHVGVISVEGKVYAVGGH---DGNEHLGSMEMFDPLTNKWM 211
Cdd:PHA03098  390 NLIYVIGGISKNDELLKTVECFSLNTNKWSKGSPLPISHYGGCAIYHDGKIYVIGGIsyiDNIKVYNIVESYNPVTNKWT 469

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 2462598394 212 MKASMNTKRRGIALASLGGPIYAIGGLDDNTCFNDVERYDIESDQWS 258
Cdd:PHA03098  470 ELSSLNFPRINASLCIFNNKIYVVGGDKYEYYINEIEVYDDKTNTWT 516
Kelch smart00612
Kelch domain;
325-371 3.52e-13

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 63.73  E-value: 3.52e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 2462598394  325 CLYVVGGFDDNSPLSSVERYDPRSNKWDYVAALTTPRGGVGIATVMG 371
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
PLN02193 PLN02193
nitrile-specifier protein
 177-354 3.78e-13

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 71.14  E-value: 3.78e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462598394 177 GVISVEGKVYAVGG-----HDGNEHLgsmEMFDPLTNKWMMKASM----NTKRRGIALASLGGPIYAIGGLDDNTCFNDV 247
Cdd:PLN02193  170 GIAQVGNKIYSFGGeftpnQPIDKHL---YVFDLETRTWSISPATgdvpHLSCLGVRMVSIGSTLYVFGGRDASRQYNGF 246

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462598394 248 ERYDIESDQWSTVAPMN---TPRGGVGSVALVNHVYAVGGNDGMASLSSVERYDPHLDKWIEVKEMGQR---RAGNGVSK 321
Cdd:PLN02193  247 YSFDTTTNEWKLLTPVEegpTPRSFHSMAADEENVYVFGGVSATARLKTLDSYNIVDKKWFHCSTPGDSfsiRGGAGLEV 326

                         170       180       190
                  ....*....|....*....|....*....|...
gi 2462598394 322 LHGCLYVVGGFdDNSPLSSVERYDPRSNKWDYV 354
Cdd:PLN02193  327 VQGKVWVVYGF-NGCEVDDVHYYDPVQDKWTQV 358
Kelch smart00612
Kelch domain;
184-230 4.11e-13

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 63.35  E-value: 4.11e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 2462598394  184 KVYAVGGHDGNEHLGSMEMFDPLTNKWMMKASMNTKRRGIALASLGG 230
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
Kelch smart00612
Kelch domain;
232-275 6.84e-13

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 62.58  E-value: 6.84e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 2462598394  232 IYAIGGLDDNTCFNDVERYDIESDQWSTVAPMNTPRGGVGSVAL 275
Cdd:smart00612   2 IYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVI 45
PLN02153 PLN02153
epithiospecifier protein
 177-354 9.06e-13

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 68.86  E-value: 9.06e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462598394 177 GVISVEGKVYAVGGH-DGNEHLGS-MEMFDPLTNKWMMKASMNTKRR----GIALASLGGPIYAIGGLDDNTCFNDVERY 250
Cdd:PLN02153   27 GIAVVGDKLYSFGGElKPNEHIDKdLYVFDFNTHTWSIAPANGDVPRisclGVRMVAVGTKLYIFGGRDEKREFSDFYSY 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462598394 251 DIESDQWSTVAPMNTPRGGVGSV-----ALVNHVYAVGG--NDGMAS----LSSVERYDPHLDKWIEVKEMG---QRRAG 316
Cdd:PLN02153  107 DTVKNEWTFLTKLDEEGGPEARTfhsmaSDENHVYVFGGvsKGGLMKtperFRTIEAYNIADGKWVQLPDPGenfEKRGG 186

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 2462598394 317 NGVSKLHGCLYVVGGF--------DDNSPLSSVERYDPRSNKWDYV 354
Cdd:PLN02153  187 AGFAVVQGKIWVVYGFatsilpggKSDYESNAVQFFDPASGKWTEV 232
Kelch smart00612
Kelch domain;
372-416 9.60e-12

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 59.49  E-value: 9.60e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 2462598394  372 KIFAVGGHNGNAYLNTVEAFDPVLNRWELVGSVSHCRAGAGVAVC 416
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVI 45
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 172-217 1.10e-11

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 59.16  E-value: 1.10e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 2462598394 172 RRRHVGVISVEGKVYAVGGHDGNEHLGSMEMFDPLTNKWMMKASMN 217
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 313-358 2.62e-11

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 58.39  E-value: 2.62e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 2462598394 313 RRAGNGVSKLHGCLYVVGGFDDNSPLSSVERYDPRSNKWDYVAALT 358
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 220-264 4.86e-11

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 57.62  E-value: 4.86e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 2462598394 220 RRGIALASLGGPIYAIGGLDDNTCFNDVERYDIESDQWSTVAPMN 264
Cdd:pfam01344   2 RSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46
Kelch smart00612
Kelch domain;
278-319 1.06e-10

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 56.41  E-value: 1.06e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2462598394  278 HVYAVGGNDGMASLSSVERYDPHLDKWIEVKEMGQRRAGNGV 319
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGV 42
PLN02153 PLN02153
epithiospecifier protein
 225-401 1.61e-10

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 62.31  E-value: 1.61e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462598394 225 LASLGGPIYAIGG-LDDNTCFN-DVERYDIESDQWStVAPMN--TPR---GGVGSVALVNHVYAVGGNDGMASLSSVERY 297
Cdd:PLN02153   28 IAVVGDKLYSFGGeLKPNEHIDkDLYVFDFNTHTWS-IAPANgdVPRiscLGVRMVAVGTKLYIFGGRDEKREFSDFYSY 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462598394 298 DPHLDKW---IEVKEMG--QRRAGNGVSKLHGCLYVVGGFDD----NSP--LSSVERYDPRSNKWdyvAALTTP------ 360
Cdd:PLN02153  107 DTVKNEWtflTKLDEEGgpEARTFHSMASDENHVYVFGGVSKgglmKTPerFRTIEAYNIADGKW---VQLPDPgenfek 183

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 2462598394 361 RGGVGIATVMGKIFAV---------GGHNgNAYLNTVEAFDPVLNRWELV 401
Cdd:PLN02153  184 RGGAGFAVVQGKIWVVygfatsilpGGKS-DYESNAVQFFDPASGKWTEV 232
PHA02790 PHA02790
Kelch-like protein; Provisional
 228-400 2.12e-10

Kelch-like protein; Provisional


Pssm-ID: 165153 [Multi-domain]  Cd Length: 480  Bit Score: 62.37  E-value: 2.12e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462598394 228 LGGPIYAIGGLDDNTCFNDVERYDIESDQWSTVAPMNTPRGGVGSVALVNHVYAVGgndGMASLSSVERYDPHLDKWIEV 307
Cdd:PHA02790  270 VGEVVYLIGGWMNNEIHNNAIAVNYISNNWIPIPPMNSPRLYASGVPANNKLYVVG---GLPNPTSVERWFHGDAAWVNM 346

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462598394 308 KEMGQRRAGNGVSKLHGCLYVVGGFDDNSPLS-------------------------------------SVERYDPRSNK 350
Cdd:PHA02790  347 PSLLKPRCNPAVASINNVIYVIGGHSETDTTTeyllpnhdqwqfgpstyyphykscalvfgrrlflvgrNAEFYCESSNT 426

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 2462598394 351 WDYVAALTTPRGGVGIATVMGKIFAVGGHNGNAYLNTVEAFDPVLNRWEL 400
Cdd:PHA02790  427 WTLIDDPIYPRDNPELIIVDNKLLLIGGFYRGSYIDTIEVYNNRTYSWNI 476
PLN02193 PLN02193
nitrile-specifier protein
 176-313 5.84e-10

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 61.12  E-value: 5.84e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462598394 176 VGVISVEGKVYAVGGHDGNEHLGSMEMFDPLTNKWMMKASMN---TKRRGIALASLGGPIYAIGGLDDNTCFNDVERYDI 252
Cdd:PLN02193  222 VRMVSIGSTLYVFGGRDASRQYNGFYSFDTTTNEWKLLTPVEegpTPRSFHSMAADEENVYVFGGVSATARLKTLDSYNI 301

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462598394 253 ESDQW---STVAPMNTPRGGVGSVALVNHVYAVGGNDGmASLSSVERYDPHLDKWIEVKEMGQR 313
Cdd:PLN02193  302 VDKKWfhcSTPGDSFSIRGGAGLEVVQGKVWVVYGFNG-CEVDDVHYYDPVQDKWTQVETFGVR 364
PHA03098 PHA03098
kelch-like protein; Provisional
 322-415 7.71e-10

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 60.94  E-value: 7.71e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462598394 322 LHGCLYVVGGFDDNS-PLSSVERYDPRSNKWDYVAALTTPRGGVGIATVMGKIFAVGGHNGNAYLNTVEAFDPVLNRWEL 400
Cdd:PHA03098  293 LNNVIYFIGGMNKNNlSVNSVVSYDTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGIYNSISLNTVESWKPGESKWRE 372

                          90
                  ....*....|....*
gi 2462598394 401 VGSVSHCRAGAGVAV 415
Cdd:PHA03098  373 EPPLIFPRYNPCVVN 387
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 360-403 2.39e-09

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 52.61  E-value: 2.39e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 2462598394 360 PRGGVGIATVMGKIFAVGGHNGNAYLNTVEAFDPVLNRWELVGS 403
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPS 44
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 266-311 9.12e-09

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 51.07  E-value: 9.12e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 2462598394 266 PRGGVGSVALVNHVYAVGGNDGMASLSSVERYDPHLDKWIEVKEMG 311
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46
BACK_KLHL12 cd18452
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also ...
 73-111 1.20e-08

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also termed CUL3-interacting protein 1 (C3IP1), or DKIR, is a substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport.


Pssm-ID: 350527 [Multi-domain]  Cd Length: 136  Bit Score: 53.56  E-value: 1.20e-08
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2462598394  73 VRLPLLPVDFLMGVVAKEQIVKQNLKCRDLLDEARNYHL 111
Cdd:cd18452    93 VRLPLLSPRYITDVVDAEPLIRCSLECRDLVDEAKKFHL 131
PLN02153 PLN02153
epithiospecifier protein
 137-319 2.92e-08

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 55.38  E-value: 2.92e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462598394 137 LFCVGGRGGSGDPF-RSIECYSINKNSWFFGPEMNSRRR----HVGVISVEGKVYAVGGHDGNEHLGSMEMFDPLTNKWM 211
Cdd:PLN02153   35 LYSFGGELKPNEHIdKDLYVFDFNTHTWSIAPANGDVPRisclGVRMVAVGTKLYIFGGRDEKREFSDFYSYDTVKNEWT 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462598394 212 MKASMNTK-----RRGIALASLGGPIYAIGGLDDN------TCFNDVERYDIESDQWSTVA-PMNT--PRGGVGSVALVN 277
Cdd:PLN02153  115 FLTKLDEEggpeaRTFHSMASDENHVYVFGGVSKGglmktpERFRTIEAYNIADGKWVQLPdPGENfeKRGGAGFAVVQG 194

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2462598394 278 HVYAV---------GGNDGMASlSSVERYDPHLDKWIEVKEMGQRRAGNGV 319
Cdd:PLN02153  195 KIWVVygfatsilpGGKSDYES-NAVQFFDPASGKWTEVETTGAKPSARSV 244
BACK_KLHL3 cd18513
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 3 (KLHL3); KLHL3 serves as ...
 43-110 1.58e-07

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 3 (KLHL3); KLHL3 serves as a substrate adapter in Cullin3 (Cul3) E3 ubiquitin ligase complexes. It is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation.


Pssm-ID: 350588 [Multi-domain]  Cd Length: 130  Bit Score: 50.07  E-value: 1.58e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462598394  43 IFEANEAWKDfHGSLLRFYENGELCDvtlKVRLPLLPVDFLMGVVAKEQIVKQNLKCRDLLDEARNYH 110
Cdd:cd18513    67 VFEAVISWIK-YDKEARLEHMAKLME---HVRLPLLPRDYLVQTVEEEALIKNNNTCKDFLIEAMKYH 130
PRK14131 PRK14131
N-acetylneuraminate epimerase;
267-390 4.54e-07

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 51.55  E-value: 4.54e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462598394 267 RGGVGsvALVNHVYAVGGNDGMASLSSVERYDPHlDKWIEVKEM-GQRRAGNGVSKLHGCLYVVGGF----DDNSP--LS 339
Cdd:PRK14131   30 KNGTG--AIDNNTVYVGLGSAGTSWYKLDLNAPS-KGWTKIAAFpGGPREQAVAAFIDGKLYVFGGIgktnSEGSPqvFD 106

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462598394 340 SVERYDPRSNKWDYVAAlTTPRGGVGIATVM---GKIFAVGGHNG---NAYLNTVEA 390
Cdd:PRK14131  107 DVYKYDPKTNSWQKLDT-RSPVGLAGHVAVSlhnGKAYITGGVNKnifDGYFEDLAA 162
Kelch_6 pfam13964
Kelch motif;
220-267 5.01e-07

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 46.17  E-value: 5.01e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 2462598394 220 RRGIALASLGGPIYAIGGLDD-NTCFNDVERYDIESDQWSTVAPMNTPR 267
Cdd:pfam13964   2 RTFHSVVSVGGYIYVFGGYTNaSPALNKLEVYNPLTKSWEELPPLPTPR 50
PRK14131 PRK14131
N-acetylneuraminate epimerase;
208-284 1.19e-06

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 50.40  E-value: 1.19e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462598394 208 NKWMMKASM-NTKRRGIALASLGGPIYAIGGLDDN------TCFNDVERYDIESDQWSTVaPMNTPRGGVGSVALVNH-- 278
Cdd:PRK14131   62 KGWTKIAAFpGGPREQAVAAFIDGKLYVFGGIGKTnsegspQVFDDVYKYDPKTNSWQKL-DTRSPVGLAGHVAVSLHng 140


                  ....*..
gi 2462598394 279 -VYAVGG 284
Cdd:PRK14131  141 kAYITGG 147
Kelch smart00612
Kelch domain;
136-183 2.41e-06

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 44.09  E-value: 2.41e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 2462598394  136 VLFCVGGRGGsGDPFRSIECYSINKNSWFFGPEMNSRRRHVGVISVEG 183
Cdd:smart00612   1 KIYVVGGFDG-GQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
Kelch_6 pfam13964
Kelch motif;
314-361 2.90e-06

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 44.25  E-value: 2.90e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 2462598394 314 RAGNGVSKLHGCLYVVGGFDD-NSPLSSVERYDPRSNKWDYVAALTTPR 361
Cdd:pfam13964   2 RTFHSVVSVGGYIYVFGGYTNaSPALNKLEVYNPLTKSWEELPPLPTPR 50
PHA02790 PHA02790
Kelch-like protein; Provisional
 132-352 6.74e-06

Kelch-like protein; Provisional


Pssm-ID: 165153 [Multi-domain]  Cd Length: 480  Bit Score: 48.12  E-value: 6.74e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462598394 132 HTAGVLFCVGGRGGSGDPFRSIECYSINkNSWFFGPEMNSRRRHVGVISVEGKVYAVGGHDGNEhlgSMEMFDPLTNKWM 211
Cdd:PHA02790  269 HVGEVVYLIGGWMNNEIHNNAIAVNYIS-NNWIPIPPMNSPRLYASGVPANNKLYVVGGLPNPT---SVERWFHGDAAWV 344

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462598394 212 MKASMNTKRRGIALASLGGPIYAIGGLDDNTcfNDVERYDIESDQWSTVAPMNTPRGGVGSVALVNHVYAVGGNdgmasl 291
Cdd:PHA02790  345 NMPSLLKPRCNPAVASINNVIYVIGGHSETD--TTTEYLLPNHDQWQFGPSTYYPHYKSCALVFGRRLFLVGRN------ 416

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462598394 292 ssVERYDPHLDKWIEVKEMGQRRAGNGVSKLHGCLYVVGGFDDNSPLSSVERYDPRSNKWD 352
Cdd:PHA02790  417 --AEFYCESSNTWTLIDDPIYPRDNPELIIVDNKLLLIGGFYRGSYIDTIEVYNNRTYSWN 475
BACK_KLHL2_Mayven cd18512
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also ...
 43-110 8.89e-06

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation.


Pssm-ID: 350587 [Multi-domain]  Cd Length: 130  Bit Score: 45.02  E-value: 8.89e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462598394  43 IFEANEAWKDfHGSLLRFYENGELCDvtlKVRLPLLPVDFLMGVVAKEQIVKQNLKCRDLLDEARNYH 110
Cdd:cd18512    67 VFEAVIAWVN-HDKEVRQEHMAHLME---HVRLPLLSREYLVQRVEEETLVKNSSACKDYLIEAMKYH 130
Kelch_3 pfam13415
Galactose oxidase, central domain;
229-267 1.28e-05

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 42.28  E-value: 1.28e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 2462598394 229 GGPIYAIGGLDD--NTCFNDVERYDIESDQWSTVAPMNTPR 267
Cdd:pfam13415   1 GDKLYIFGGLGFdgQTRLNDLYVYDLDTNTWTQIGDLPPPR 41
BTB_POZ_KLHL8 cd18238
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 52-73 2.62e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349547 [Multi-domain]  Cd Length: 120  Bit Score: 43.43  E-value: 2.62e-05
                          10        20
                  ....*....|....*....|..
gi 2462598394  52 DFHGSLLRFYENGELCDVTLKV 73
Cdd:cd18238     1 DSFKVLHQFYENGELCDVTLKV 22
muta_rot_YjhT TIGR03547
mutatrotase, YjhT family; Members of this protein family contain multiple copies of the ...
 267-393 1.38e-04

mutatrotase, YjhT family; Members of this protein family contain multiple copies of the beta-propeller-forming Kelch repeat. All are full-length homologs to YjhT of Escherichia coli, which has been identified as a mutarotase for sialic acid. This protein improves bacterial ability to obtain host sialic acid, and thus serves as a virulence factor. Some bacteria carry what appears to be a cyclically permuted homolog of this protein.


Pssm-ID: 274641 [Multi-domain]  Cd Length: 346  Bit Score: 43.85  E-value: 1.38e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462598394 267 RGGVGsvALVNHVYAVGGNDGMASLSSVERYDPHlDKWIEVKEM-GQRRAGNGVSKLHGCLYVVGGF----DDNSP--LS 339
Cdd:TIGR03547   9 KNGTG--AIIGDKVYVGLGSAGTSWYKLDLKKPS-KGWQKIADFpGGPRNQAVAAAIDGKLYVFGGIgkanSEGSPqvFD 85

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462598394 340 SVERYDPRSNKWDYVAAlTTPRGGVGIATVM---GKIFAVGGHNG---NAYLNTVEAFDP 393
Cdd:TIGR03547  86 DVYRYDPKKNSWQKLDT-RSPVGLLGASGFSlhnGQAYFTGGVNKnifDGYFADLSAADK 144
PHA02713 PHA02713
hypothetical protein; Provisional
 224-376 7.22e-04

hypothetical protein; Provisional


Pssm-ID: 165086 [Multi-domain]  Cd Length: 557  Bit Score: 41.92  E-value: 7.22e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462598394 224 ALASLGGPIYAIGGLD-DNTCFNDVERYDIESDQWSTVAPMNTPRGGVGSVALVNHVYAVGGNDGMASLSSVERYDPHLD 302
Cdd:PHA02713  298 ASAIVDNEIIIAGGYNfNNPSLNKVYKINIENKIHVELPPMIKNRCRFSLAVIDDTIYAIGGQNGTNVERTIECYTMGDD 377

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462598394 303 KWIEVKEMGQRRAGNGVSKLHGCLYVVGG-----------------FDDNSPLSS-VERYDPRSNKWDYVAALTTPRGGV 364
Cdd:PHA02713  378 KWKMLPDMPIALSSYGMCVLDQYIYIIGGrtehidytsvhhmnsidMEEDTHSSNkVIRYDTVNNIWETLPNFWTGTIRP 457

                         170
                  ....*....|..
gi 2462598394 365 GIATVMGKIFAV 376
Cdd:PHA02713  458 GVVSHKDDIYVV 469
Kelch_2 pfam07646
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 313-357 1.21e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 462220 [Multi-domain]  Cd Length: 47  Bit Score: 36.55  E-value: 1.21e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 2462598394 313 RRAGNGVSKLHGCLYVVGGFDDNSPLSS--VERYDPRSNKWDYVAAL 357
Cdd:pfam07646   1 PRYPHASSVPGGKLYVVGGSDGLGDLSSsdVLVYDPETNVWTEVPRL 47
Kelch_4 pfam13418
Galactose oxidase, central domain;
232-263 1.82e-03

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 36.05  E-value: 1.82e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 2462598394 232 IYAIGGL-DDNTCFNDVERYDIESDQWSTVAPM 263
Cdd:pfam13418  15 IYLFGGEgEDGTLLSDLWVFDLSTNEWTRLGSL 47
Kelch_6 pfam13964
Kelch motif;
173-220 1.95e-03

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 36.16  E-value: 1.95e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 2462598394 173 RRHVGVISVEGKVYAVGG-HDGNEHLGSMEMFDPLTNKWMMKASMNTKR 220
Cdd:pfam13964   2 RTFHSVVSVGGYIYVFGGyTNASPALNKLEVYNPLTKSWEELPPLPTPR 50
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 135-170 2.11e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 36.05  E-value: 2.11e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 2462598394 135 GVLFCVGGRGGsGDPFRSIECYSINKNSWFFGPEMN 170
Cdd:pfam01344  12 GKIYVIGGFDG-NQSLNSVEVYDPETNTWSKLPSMP 46
Kelch_3 pfam13415
Galactose oxidase, central domain;
182-228 5.16e-03

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 34.96  E-value: 5.16e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 2462598394 182 EGKVYAVGG--HDGNEHLGSMEMFDPLTNKWMMKASMNTKRRGIALASL 228
Cdd:pfam13415   1 GDKLYIFGGlgFDGQTRLNDLYVYDLDTNTWTQIGDLPPPRSGHSATYI 49
Kelch_3 pfam13415
Galactose oxidase, central domain;
326-361 5.70e-03

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 34.96  E-value: 5.70e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 2462598394 326 LYVVGGFDD--NSPLSSVERYDPRSNKWDYVAALTTPR 361
Cdd:pfam13415   4 LYIFGGLGFdgQTRLNDLYVYDLDTNTWTQIGDLPPPR 41
Kelch_6 pfam13964
Kelch motif;
360-408 7.83e-03

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 34.23  E-value: 7.83e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 2462598394 360 PRGGVGIATVMGKIFAVGG-HNGNAYLNTVEAFDPVLNRWELVGSVSHCR 408
Cdd:pfam13964   1 PRTFHSVVSVGGYIYVFGGyTNASPALNKLEVYNPLTKSWEELPPLPTPR 50
PHA02713 PHA02713
hypothetical protein; Provisional
 167-282 9.84e-03

hypothetical protein; Provisional


Pssm-ID: 165086 [Multi-domain]  Cd Length: 557  Bit Score: 38.07  E-value: 9.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462598394 167 PEMNSRRRHVGVISVEGKVYAVGGHDGNEHLGSMEMFDPLTNKWMMKASMNTKRRGIALASLGGPIYAIGG--------- 237
Cdd:PHA02713  336 PPMIKNRCRFSLAVIDDTIYAIGGQNGTNVERTIECYTMGDDKWKMLPDMPIALSSYGMCVLDQYIYIIGGrtehidyts 415

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2462598394 238 --------LDDNT-CFNDVERYDIESDQWSTVAPMNTPRGGVGSVALVNHVYAV 282
Cdd:PHA02713  416 vhhmnsidMEEDThSSNKVIRYDTVNNIWETLPNFWTGTIRPGVVSHKDDIYVV 469
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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