NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2462613146|ref|XP_054213608|]
View 

laminin subunit beta-4 isoform X6 [Homo sapiens]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Laminin_N pfam00055
Laminin N-terminal (Domain VI);
28-263 5.69e-94

Laminin N-terminal (Domain VI);


:

Pssm-ID: 459653  Cd Length: 230  Bit Score: 302.96  E-value: 5.69e-94
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613146   28 CHPTTGDLLVGRntQLMASSTCGLSRAQKYCILSYLEGEQKCFICDSRFPYdpydqpNSHTIENVIvSFEPDREKKWWQS 107
Cdd:pfam00055    1 CYPAFGNLAFGR--EVSATSTCGLNGPERYCILSGLEGGKKCFICDSRDPH------NSHPPSNLT-DSNNGTNETWWQS 71

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613146  108 ENGL---DHVSIRLDLEALFRFSHLILTFKTFRPAAMLVERSTDYGHNWKVFKYFAKDCATSFpNITSGQAQGVGD--IV 182
Cdd:pfam00055   72 ETGViqyENVNLTLDLGKEFHFTYLILKFKSPRPAAMVLERSTDFGKTWQPYQYFASDCRRTF-GRPSGPSRGIKDdeVI 150

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613146  183 CDSKYSDIEPSTGGEVVLKVL--DPSFEIENpYSPYIQDLVTLTNLRINFTKLHTLGDALLGRRQndSLDKYYYALYEMI 260
Cdd:pfam00055  151 CTSEYSDISPLTGGEVIFSTLegRPSANIFD-YSPELQDWLTATNIRIRLLRLHTLGDELLDDPS--VLRKYYYAISDIS 227


                   ...
gi 2462613146  261 VRG 263
Cdd:pfam00055  228 VGG 230
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 1080-1128 4.02e-12

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


:

Pssm-ID: 395007  Cd Length: 49  Bit Score: 62.37  E-value: 4.02e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 2462613146 1080 CDCDPRTSQSSHCDQLTGQCPCKLGYGGKRCSECQENYYGDPPGRCIPC 1128
Cdd:pfam00053    1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 454-503 4.47e-11

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


:

Pssm-ID: 238012  Cd Length: 50  Bit Score: 59.29  E-value: 4.47e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 2462613146  454 PCDCNPLGSLPFlTCDVDTGQCLCLSYVTGAHCEECTVGYWGLGNHLHGC 503
Cdd:cd00055      1 PCDCNGHGSLSG-QCDPGTGQCECKPNTTGRRCDRCAPGYYGLPSQGGGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 505-549 9.05e-11

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


:

Pssm-ID: 238012  Cd Length: 50  Bit Score: 58.52  E-value: 9.05e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 2462613146  505 PCDCDIGGAYSNVCSPKNGQCECRPHVTGRSCSEPAPGYFFAPLN 549
Cdd:cd00055      1 PCDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLPSQ 45
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 395-452 1.82e-10

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


:

Pssm-ID: 395007  Cd Length: 49  Bit Score: 57.36  E-value: 1.82e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 2462613146  395 CECDPDGTiSGGICVSHSdpalgsvaGQCLCKENVEGAKCDQCKPNHYGLSATDPLGC 452
Cdd:pfam00053    1 CDCNPHGS-LSDTCDPET--------GQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 1127-1176 5.26e-10

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


:

Pssm-ID: 238012  Cd Length: 50  Bit Score: 56.21  E-value: 5.26e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 2462613146 1127 PCDCNRAGTQKPICDPDTGMCRCREGVSGQRCDRCARGHSQEFPTCLQCH 1176
Cdd:cd00055      1 PCDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLPSQGGGCQ 50
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 822-865 1.02e-09

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


:

Pssm-ID: 395007  Cd Length: 49  Bit Score: 55.44  E-value: 1.02e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 2462613146  822 QGSKDTVCDQVTGQCPCHGEVSGRRCDRCLAGYFGFPSCHPCPC 865
Cdd:pfam00053    6 HGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 768-809 1.47e-08

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


:

Pssm-ID: 238012  Cd Length: 50  Bit Score: 51.97  E-value: 1.47e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2462613146  768 ACKCHPQGSVGSSCSRLGGQCQCKPLVVGRCCDRCSTGSYDL 809
Cdd:cd00055      1 PCDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGL 42
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 1033-1077 2.53e-08

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


:

Pssm-ID: 395007  Cd Length: 49  Bit Score: 51.59  E-value: 2.53e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 2462613146 1033 ECPPGGGACL-CDPVTGACPCLPNVTGLACDRCADGYWNLV--PGRGC 1077
Cdd:pfam00053    2 DCNPHGSLSDtCDPETGQCLCKPGVTGRHCDRCKPGYYGLPsdPPQGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 862-909 2.37e-07

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


:

Pssm-ID: 238012  Cd Length: 50  Bit Score: 48.89  E-value: 2.37e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2462613146  862 PCPCNRFAEL---CDPETGSCFnCGGFTTGRNCERCIDGYYGNPSSGQPCR 909
Cdd:cd00055      1 PCDCNGHGSLsgqCDPGTGQCE-CKPNTTGRRCDRCAPGYYGLPSQGGGCQ 50
HEC1 super family cl34933
Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell ...
 1250-1495 7.05e-07

Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell division, chromosome partitioning];


The actual alignment was detected with superfamily member COG5185:

Pssm-ID: 444066 [Multi-domain]  Cd Length: 594  Bit Score: 53.81  E-value: 7.05e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613146 1250 SVRRQIMQLNEQLKAVYEFQdlkdTIERAKNEADLLLEDLQEEIDLQSSVLNASIADSSENIKKYYHIS--SSAEKKINE 1327
Cdd:COG5185    306 DIKKATESLEEQLAAAEAEQ----ELEESKRETETGIQNLTAEIEQGQESLTENLEAIKEEIENIVGEVelSKSSEELDS 381

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613146 1328 TSSTINTsanTRNDLLTILDTLTSKGNLSLERL-KQIKIPDIQI--LNEKVCGDPGNVPCVPLPCGGALCTGRKGHRKCR 1404
Cdd:COG5185    382 FKDTIES---TKESLDEIPQNQRGYAQEILATLeDTLKAADRQIeeLQRQIEQATSSNEEVSKLLNELISELNKVMREAD 458

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613146 1405 GpgchGSLTLSTNALQK-AQEAKSIIRNLDKQVRGLKNQIESISEQAEVSKNNalqLREKLGNIRNQSDSEEENINLFIK 1483
Cdd:COG5185    459 E----ESQSRLEEAYDEiNRSVRSKKEDLNEELTQIESRVSTLKATLEKLRAK---LERQLEGVRSKLDQVAESLKDFMR 531

                          250
                   ....*....|..
gi 2462613146 1484 KVKNFLLEENVP 1495
Cdd:COG5185    532 ARGYAHILALEN 543
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 264-320 2.13e-06

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


:

Pssm-ID: 238012  Cd Length: 50  Bit Score: 46.19  E-value: 2.13e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613146  264 SCFCNGHAS---ECRPmqkmrgdvfsppgmVHGQCVCQHNTDGPNCERCKDFFQDAPWRP 320
Cdd:cd00055      1 PCDCNGHGSlsgQCDP--------------GTGQCECKPNTTGRRCDRCAPGYYGLPSQG 46
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 970-1012 2.48e-06

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


:

Pssm-ID: 395007  Cd Length: 49  Bit Score: 45.81  E-value: 2.48e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 2462613146  970 CACNNNIDVTDpeSCSRVTGECLrCLHNTQGANCQLCKPGHYG 1012
Cdd:pfam00053    1 CDCNPHGSLSD--TCDPETGQCL-CKPGVTGRHCDRCKPGYYG 40
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 332-382 2.31e-05

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


:

Pssm-ID: 395007  Cd Length: 49  Bit Score: 43.11  E-value: 2.31e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2462613146  332 CSCNSHSS---RCHFdmttylasgglSGGVCeDCQHNTEGQHCDRCRPLFYRDP 382
Cdd:pfam00053    1 CDCNPHGSlsdTCDP-----------ETGQC-LCKPGVTGRHCDRCKPGYYGLP 42
 
Name Accession Description Interval E-value
Laminin_N pfam00055
Laminin N-terminal (Domain VI);
28-263 5.69e-94

Laminin N-terminal (Domain VI);


Pssm-ID: 459653  Cd Length: 230  Bit Score: 302.96  E-value: 5.69e-94
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613146   28 CHPTTGDLLVGRntQLMASSTCGLSRAQKYCILSYLEGEQKCFICDSRFPYdpydqpNSHTIENVIvSFEPDREKKWWQS 107
Cdd:pfam00055    1 CYPAFGNLAFGR--EVSATSTCGLNGPERYCILSGLEGGKKCFICDSRDPH------NSHPPSNLT-DSNNGTNETWWQS 71

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613146  108 ENGL---DHVSIRLDLEALFRFSHLILTFKTFRPAAMLVERSTDYGHNWKVFKYFAKDCATSFpNITSGQAQGVGD--IV 182
Cdd:pfam00055   72 ETGViqyENVNLTLDLGKEFHFTYLILKFKSPRPAAMVLERSTDFGKTWQPYQYFASDCRRTF-GRPSGPSRGIKDdeVI 150

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613146  183 CDSKYSDIEPSTGGEVVLKVL--DPSFEIENpYSPYIQDLVTLTNLRINFTKLHTLGDALLGRRQndSLDKYYYALYEMI 260
Cdd:pfam00055  151 CTSEYSDISPLTGGEVIFSTLegRPSANIFD-YSPELQDWLTATNIRIRLLRLHTLGDELLDDPS--VLRKYYYAISDIS 227


                   ...
gi 2462613146  261 VRG 263
Cdd:pfam00055  228 VGG 230
LamNT smart00136
Laminin N-terminal domain (domain VI); N-terminal domain of laminins and laminin-related ...
 23-263 1.46e-66

Laminin N-terminal domain (domain VI); N-terminal domain of laminins and laminin-related protein such as Unc-6/ netrins.


Pssm-ID: 214532  Cd Length: 238  Bit Score: 224.93  E-value: 1.46e-66
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613146    23 CNRGACHPTTGDLLVGRntQLMASSTCGLSRAQKYCILS-YLEGEQKCFICDSRFPYdpydqpNSHTIENVIVSFEPDRE 101
Cdd:smart00136    2 GRPRSCYPPFVNLAFGR--EVTATSTCGEPGPERYCKLVgHTEQGKKCDYCDARNPR------RSHPAENLTDGNNPNNP 73

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613146   102 KkWWQSEN---GLDHVSIRLDLEALFRFSHLILTFKTFRPAAMLVERStDYGHNWKVFKYFAKDCATSFPNITSG--QAQ 176
Cdd:smart00136   74 T-WWQSEPlsnGPQNVNLTLDLGKEFHVTYVILKFCSPRPSLWILERS-DFGKTWQPWQYFSSDCRRTFGRPPRGpiTKG 151

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613146   177 GVGDIVCDSKYSDIEPSTGGEVVLKVLDPSFEIEN-PYSPYIQDLVTLTNLRINFTKLHTLGDALLGRRQNDsLDKYYYA 255
Cdd:smart00136  152 NEDEVICTSEYSDIVPLEGGEIAFSLLEGRPSATDfDNSPVLQEWVTATNIRVRLTRLRTLGDELMDDRPEV-TRRYYYA 230


                    ....*...
gi 2462613146   256 LYEMIVRG 263
Cdd:smart00136  231 ISDIAVGG 238
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 1080-1128 4.02e-12

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 62.37  E-value: 4.02e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 2462613146 1080 CDCDPRTSQSSHCDQLTGQCPCKLGYGGKRCSECQENYYGDPPGRCIPC 1128
Cdd:pfam00053    1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 454-503 4.47e-11

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 59.29  E-value: 4.47e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 2462613146  454 PCDCNPLGSLPFlTCDVDTGQCLCLSYVTGAHCEECTVGYWGLGNHLHGC 503
Cdd:cd00055      1 PCDCNGHGSLSG-QCDPGTGQCECKPNTTGRRCDRCAPGYYGLPSQGGGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 505-549 9.05e-11

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 58.52  E-value: 9.05e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 2462613146  505 PCDCDIGGAYSNVCSPKNGQCECRPHVTGRSCSEPAPGYFFAPLN 549
Cdd:cd00055      1 PCDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLPSQ 45
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
1080-1125 9.69e-11

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 58.09  E-value: 9.69e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 2462613146  1080 CDCDPRTSQSSHCDQLTGQCPCKLGYGGKRCSECQENYYGDPPGRC 1125
Cdd:smart00180    1 CDCDPGGSASGTCDPDTGQCECKPNVTGRRCDRCAPGYYGDGPPGC 46
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 395-452 1.82e-10

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 57.36  E-value: 1.82e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 2462613146  395 CECDPDGTiSGGICVSHSdpalgsvaGQCLCKENVEGAKCDQCKPNHYGLSATDPLGC 452
Cdd:pfam00053    1 CDCNPHGS-LSDTCDPET--------GQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 1079-1121 5.01e-10

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 56.21  E-value: 5.01e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 2462613146 1079 SCDCDPRTSQSSHCDQLTGQCPCKLGYGGKRCSECQENYYGDP 1121
Cdd:cd00055      1 PCDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLP 43
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 1127-1176 5.26e-10

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 56.21  E-value: 5.26e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 2462613146 1127 PCDCNRAGTQKPICDPDTGMCRCREGVSGQRCDRCARGHSQEFPTCLQCH 1176
Cdd:cd00055      1 PCDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLPSQGGGCQ 50
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 455-508 7.37e-10

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 55.82  E-value: 7.37e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2462613146  455 CDCNPLGSLPFlTCDVDTGQCLCLSYVTGAHCEECTVGYWGlgnhLHGCSPCDC 508
Cdd:pfam00053    1 CDCNPHGSLSD-TCDPETGQCLCKPGVTGRHCDRCKPGYYG----LPSDPPQGC 49
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 822-865 1.02e-09

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 55.44  E-value: 1.02e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 2462613146  822 QGSKDTVCDQVTGQCPCHGEVSGRRCDRCLAGYFGFPSCHPCPC 865
Cdd:pfam00053    6 HGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
506-549 1.64e-09

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 54.62  E-value: 1.64e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 2462613146   506 CDCDIGGAYSNVCSPKNGQCECRPHVTGRSCSEPAPGYFFAPLN 549
Cdd:smart00180    1 CDCDPGGSASGTCDPDTGQCECKPNVTGRRCDRCAPGYYGDGPP 44
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
1128-1172 2.49e-09

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 54.24  E-value: 2.49e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 2462613146  1128 CDCNRAGTQKPICDPDTGMCRCREGVSGQRCDRCARGHSQE-FPTC 1172
Cdd:smart00180    1 CDCDPGGSASGTCDPDTGQCECKPNVTGRRCDRCAPGYYGDgPPGC 46
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 394-453 7.53e-09

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 53.13  E-value: 7.53e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613146  394 PCECDPDGTISGGiCVSHSdpalgsvaGQCLCKENVEGAKCDQCKPNHYGLsATDPLGCQ 453
Cdd:cd00055      1 PCDCNGHGSLSGQ-CDPGT--------GQCECKPNTTGRRCDRCAPGYYGL-PSQGGGCQ 50
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 1128-1165 8.52e-09

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 52.74  E-value: 8.52e-09
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2462613146 1128 CDCNRAGTQKPICDPDTGMCRCREGVSGQRCDRCARGH 1165
Cdd:pfam00053    1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGY 38
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
455-503 1.19e-08

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 52.31  E-value: 1.19e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*....
gi 2462613146   455 CDCNPLGSLPFlTCDVDTGQCLCLSYVTGAHCEECTVGYWglGNHLHGC 503
Cdd:smart00180    1 CDCDPGGSASG-TCDPDTGQCECKPNVTGRRCDRCAPGYY--GDGPPGC 46
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 768-809 1.47e-08

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 51.97  E-value: 1.47e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2462613146  768 ACKCHPQGSVGSSCSRLGGQCQCKPLVVGRCCDRCSTGSYDL 809
Cdd:cd00055      1 PCDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGL 42
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 769-809 1.71e-08

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 51.97  E-value: 1.71e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 2462613146  769 CKCHPQGSVGSSCSRLGGQCQCKPLVVGRCCDRCSTGSYDL 809
Cdd:pfam00053    1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGL 41
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 1033-1077 2.53e-08

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 51.59  E-value: 2.53e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 2462613146 1033 ECPPGGGACL-CDPVTGACPCLPNVTGLACDRCADGYWNLV--PGRGC 1077
Cdd:pfam00053    2 DCNPHGSLSDtCDPETGQCLCKPGVTGRHCDRCKPGYYGLPsdPPQGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 1021-1078 3.12e-08

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 51.20  E-value: 3.12e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462613146 1021 RCSCHASGVSPMECppgggaclcDPVTGACPCLPNVTGLACDRCADGYWNL-VPGRGCQ 1078
Cdd:cd00055      1 PCDCNGHGSLSGQC---------DPGTGQCECKPNTTGRRCDRCAPGYYGLpSQGGGCQ 50
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 822-859 5.50e-08

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 50.43  E-value: 5.50e-08
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2462613146  822 QGSKDTVCDQVTGQCPCHGEVSGRRCDRCLAGYFGFPS 859
Cdd:cd00055      7 HGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLPS 44
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
1022-1077 8.30e-08

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 50.00  E-value: 8.30e-08
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462613146  1022 CSCHASGVSPMECppgggaclcDPVTGACPCLPNVTGLACDRCADGYWNlVPGRGC 1077
Cdd:smart00180    1 CDCDPGGSASGTC---------DPDTGQCECKPNVTGRRCDRCAPGYYG-DGPPGC 46
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
395-448 1.22e-07

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 49.62  E-value: 1.22e-07
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....
gi 2462613146   395 CECDPDGTISGGiCVSHSdpalgsvaGQCLCKENVEGAKCDQCKPNHYGLSATD 448
Cdd:smart00180    1 CDCDPGGSASGT-CDPDT--------GQCECKPNVTGRRCDRCAPGYYGDGPPG 45
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 862-909 2.37e-07

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 48.89  E-value: 2.37e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2462613146  862 PCPCNRFAEL---CDPETGSCFnCGGFTTGRNCERCIDGYYGNPSSGQPCR 909
Cdd:cd00055      1 PCDCNGHGSLsgqCDPGTGQCE-CKPNTTGRRCDRCAPGYYGLPSQGGGCQ 50
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
769-808 2.75e-07

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 48.46  E-value: 2.75e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 2462613146   769 CKCHPQGSVGSSCSRLGGQCQCKPLVVGRCCDRCSTGSYD 808
Cdd:smart00180    1 CDCDPGGSASGTCDPDTGQCECKPNVTGRRCDRCAPGYYG 40
HEC1 COG5185
Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell ...
 1250-1495 7.05e-07

Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 444066 [Multi-domain]  Cd Length: 594  Bit Score: 53.81  E-value: 7.05e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613146 1250 SVRRQIMQLNEQLKAVYEFQdlkdTIERAKNEADLLLEDLQEEIDLQSSVLNASIADSSENIKKYYHIS--SSAEKKINE 1327
Cdd:COG5185    306 DIKKATESLEEQLAAAEAEQ----ELEESKRETETGIQNLTAEIEQGQESLTENLEAIKEEIENIVGEVelSKSSEELDS 381

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613146 1328 TSSTINTsanTRNDLLTILDTLTSKGNLSLERL-KQIKIPDIQI--LNEKVCGDPGNVPCVPLPCGGALCTGRKGHRKCR 1404
Cdd:COG5185    382 FKDTIES---TKESLDEIPQNQRGYAQEILATLeDTLKAADRQIeeLQRQIEQATSSNEEVSKLLNELISELNKVMREAD 458

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613146 1405 GpgchGSLTLSTNALQK-AQEAKSIIRNLDKQVRGLKNQIESISEQAEVSKNNalqLREKLGNIRNQSDSEEENINLFIK 1483
Cdd:COG5185    459 E----ESQSRLEEAYDEiNRSVRSKKEDLNEELTQIESRVSTLKATLEKLRAK---LERQLEGVRSKLDQVAESLKDFMR 531

                          250
                   ....*....|..
gi 2462613146 1484 KVKNFLLEENVP 1495
Cdd:COG5185    532 ARGYAHILALEN 543
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
822-858 8.73e-07

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 46.92  E-value: 8.73e-07
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 2462613146   822 QGSKDTVCDQVTGQCPCHGEVSGRRCDRCLAGYFGFP 858
Cdd:smart00180    6 GGSASGTCDPDTGQCECKPNVTGRRCDRCAPGYYGDG 42
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 264-320 2.13e-06

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 46.19  E-value: 2.13e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613146  264 SCFCNGHAS---ECRPmqkmrgdvfsppgmVHGQCVCQHNTDGPNCERCKDFFQDAPWRP 320
Cdd:cd00055      1 PCDCNGHGSlsgQCDP--------------GTGQCECKPNTTGRRCDRCAPGYYGLPSQG 46
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 970-1012 2.48e-06

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 45.81  E-value: 2.48e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 2462613146  970 CACNNNIDVTDpeSCSRVTGECLrCLHNTQGANCQLCKPGHYG 1012
Cdd:pfam00053    1 CDCNPHGSLSD--TCDPETGQCL-CKPGVTGRHCDRCKPGYYG 40
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 969-1016 3.04e-06

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 45.42  E-value: 3.04e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 2462613146  969 PCACNNNIDVtdPESCSRVTGECLrCLHNTQGANCQLCKPGHYGSALN 1016
Cdd:cd00055      1 PCDCNGHGSL--SGQCDPGTGQCE-CKPNTTGRRCDRCAPGYYGLPSQ 45
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 506-544 4.98e-06

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 45.04  E-value: 4.98e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 2462613146  506 CDCDIGGAYSNVCSPKNGQCECRPHVTGRSCSEPAPGYF 544
Cdd:pfam00053    1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYY 39
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 332-382 2.31e-05

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 43.11  E-value: 2.31e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2462613146  332 CSCNSHSS---RCHFdmttylasgglSGGVCeDCQHNTEGQHCDRCRPLFYRDP 382
Cdd:pfam00053    1 CDCNPHGSlsdTCDP-----------ETGQC-LCKPGVTGRHCDRCKPGYYGLP 42
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 331-384 2.96e-05

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 42.73  E-value: 2.96e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462613146  331 SCSCNSHSS---RCHFDmttylasgglsGGVCEdCQHNTEGQHCDRCRPLFYRDPLK 384
Cdd:cd00055      1 PCDCNGHGSlsgQCDPG-----------TGQCE-CKPNTTGRRCDRCAPGYYGLPSQ 45
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 1248-1555 5.24e-05

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 48.09  E-value: 5.24e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613146 1248 HDSVRRQIMQLNEQlkavyeFQDLKDTIERAKNEadllLEDLQEEID-LQSSVLNASiaDSSENIKKyyhissSAEKKIN 1326
Cdd:TIGR04523  213 NKSLESQISELKKQ------NNQLKDNIEKKQQE----INEKTTEISnTQTQLNQLK--DEQNKIKK------QLSEKQK 274

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613146 1327 EtsstINTSANTRNDLLTILDTLTSKgnlsLERLKQIKIPDI-QILNEKVcgdpgnvpcvplpcggalctgrkghrkcrg 1405
Cdd:TIGR04523  275 E----LEQNNKKIKELEKQLNQLKSE----ISDLNNQKEQDWnKELKSEL------------------------------ 316

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613146 1406 pgchgsltlsTNALQKAQEAKSIIRNLDKQVRGLKNQIESISEQAEVSKNNAL----QLREK---LGNIRNQSDSEEENI 1478
Cdd:TIGR04523  317 ----------KNQEKKLEEIQNQISQNNKIISQLNEQISQLKKELTNSESENSekqrELEEKqneIEKLKKENQSYKQEI 386

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613146 1479 NLFIKKVKNflLEENVppEDIEKVANgVLDIHLpipsQNLTDELVKIQKHMQLCEDYRTDEN----RLNEEaDGAQKLLV 1554
Cdd:TIGR04523  387 KNLESQIND--LESKI--QNQEKLNQ-QKDEQI----KKLQQEKELLEKEIERLKETIIKNNseikDLTNQ-DSVKELII 456


                   .
gi 2462613146 1555 K 1555
Cdd:TIGR04523  457 K 457
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 863-908 1.28e-04

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 41.18  E-value: 1.28e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 2462613146  863 CPCN---RFAELCDPETGSCFnCGGFTTGRNCERCIDGYYGNPS-SGQPC 908
Cdd:pfam00053    1 CDCNphgSLSDTCDPETGQCL-CKPGVTGRHCDRCKPGYYGLPSdPPQGC 49
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
972-1013 5.55e-04

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 39.22  E-value: 5.55e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 2462613146   972 CNNNIDVTDPESCSRVTGECLrCLHNTQGANCQLCKPGHYGS 1013
Cdd:smart00180    1 CDCDPGGSASGTCDPDTGQCE-CKPNVTGRRCDRCAPGYYGD 41
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
863-905 5.88e-04

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 39.22  E-value: 5.88e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 2462613146   863 CPCNR---FAELCDPETGSCfNCGGFTTGRNCERCIDGYYGNPSSG 905
Cdd:smart00180    1 CDCDPggsASGTCDPDTGQC-ECKPNVTGRRCDRCAPGYYGDGPPG 45
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
332-382 5.88e-04

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 39.22  E-value: 5.88e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....
gi 2462613146   332 CSCN---SHSSRCHFDmttylasgglsGGVCEdCQHNTEGQHCDRCRPLFYRDP 382
Cdd:smart00180    1 CDCDpggSASGTCDPD-----------TGQCE-CKPNVTGRRCDRCAPGYYGDG 42
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 265-323 1.08e-03

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 38.49  E-value: 1.08e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462613146  265 CFCNGHAS---ECRPMQkmrgdvfsppgmvhGQCVCQHNTDGPNCERCKDFFQDAPWRPAAD 323
Cdd:pfam00053    1 CDCNPHGSlsdTCDPET--------------GQCLCKPGVTGRHCDRCKPGYYGLPSDPPQG 48
PRK04778 PRK04778
septation ring formation regulator EzrA; Provisional
 1242-1563 1.31e-03

septation ring formation regulator EzrA; Provisional


Pssm-ID: 179877 [Multi-domain]  Cd Length: 569  Bit Score: 43.29  E-value: 1.31e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613146 1242 LKVKDY---HDSVRRQIMQLNEQLKAVYEfqDLKDT-IERAKNEadllLEDLQEEIDLQSSVLNASIAdssenikkyyhi 1317
Cdd:PRK04778   242 LVEEGYhldHLDIEKEIQDLKEQIDENLA--LLEELdLDEAEEK----NEEIQERIDQLYDILEREVK------------ 303

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613146 1318 sssAEKKINETSSTINTS---ANTRNDLLTildtltskgnLSLERLKQikipdiqilnekvcgdpgnvpcvplpcggalc 1394
Cdd:PRK04778   304 ---ARKYVEKNSDTLPDFlehAKEQNKELK----------EEIDRVKQ-------------------------------- 338

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613146 1395 tgrkghrkcrgpgchgSLTLSTNALQKAQEAKSIIRNLDKQVRG--------------LKNQIESISEQAEVSKNNALQL 1460
Cdd:PRK04778   339 ----------------SYTLNESELESVRQLEKQLESLEKQYDEiteriaeqeiayseLQEELEEILKQLEEIEKEQEKL 402

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613146 1461 REKLGNIRNQSDSEEENINLFIKK---VKNFLLEENVP--PEDI----EKVANGVldihlpipsQNLTDELVKIQKHM-- 1529
Cdd:PRK04778   403 SEMLQGLRKDELEAREKLERYRNKlheIKRYLEKSNLPglPEDYlemfFEVSDEI---------EALAEELEEKPINMea 473

                          330       340       350
                   ....*....|....*....|....*....|....*.
gi 2462613146 1530 --QLCEDYRTDENRLNEEADgaqKLLVKAKAAENLL 1563
Cdd:PRK04778   474 vnRLLEEATEDVETLEEETE---ELVENATLTEQLI 506
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
291-313 1.48e-03

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 38.06  E-value: 1.48e-03
                            10        20
                    ....*....|....*....|...
gi 2462613146   291 VHGQCVCQHNTDGPNCERCKDFF 313
Cdd:smart00180   16 DTGQCECKPNVTGRRCDRCAPGY 38
 
Name Accession Description Interval E-value
Laminin_N pfam00055
Laminin N-terminal (Domain VI);
28-263 5.69e-94

Laminin N-terminal (Domain VI);


Pssm-ID: 459653  Cd Length: 230  Bit Score: 302.96  E-value: 5.69e-94
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613146   28 CHPTTGDLLVGRntQLMASSTCGLSRAQKYCILSYLEGEQKCFICDSRFPYdpydqpNSHTIENVIvSFEPDREKKWWQS 107
Cdd:pfam00055    1 CYPAFGNLAFGR--EVSATSTCGLNGPERYCILSGLEGGKKCFICDSRDPH------NSHPPSNLT-DSNNGTNETWWQS 71

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613146  108 ENGL---DHVSIRLDLEALFRFSHLILTFKTFRPAAMLVERSTDYGHNWKVFKYFAKDCATSFpNITSGQAQGVGD--IV 182
Cdd:pfam00055   72 ETGViqyENVNLTLDLGKEFHFTYLILKFKSPRPAAMVLERSTDFGKTWQPYQYFASDCRRTF-GRPSGPSRGIKDdeVI 150

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613146  183 CDSKYSDIEPSTGGEVVLKVL--DPSFEIENpYSPYIQDLVTLTNLRINFTKLHTLGDALLGRRQndSLDKYYYALYEMI 260
Cdd:pfam00055  151 CTSEYSDISPLTGGEVIFSTLegRPSANIFD-YSPELQDWLTATNIRIRLLRLHTLGDELLDDPS--VLRKYYYAISDIS 227


                   ...
gi 2462613146  261 VRG 263
Cdd:pfam00055  228 VGG 230
LamNT smart00136
Laminin N-terminal domain (domain VI); N-terminal domain of laminins and laminin-related ...
 23-263 1.46e-66

Laminin N-terminal domain (domain VI); N-terminal domain of laminins and laminin-related protein such as Unc-6/ netrins.


Pssm-ID: 214532  Cd Length: 238  Bit Score: 224.93  E-value: 1.46e-66
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613146    23 CNRGACHPTTGDLLVGRntQLMASSTCGLSRAQKYCILS-YLEGEQKCFICDSRFPYdpydqpNSHTIENVIVSFEPDRE 101
Cdd:smart00136    2 GRPRSCYPPFVNLAFGR--EVTATSTCGEPGPERYCKLVgHTEQGKKCDYCDARNPR------RSHPAENLTDGNNPNNP 73

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613146   102 KkWWQSEN---GLDHVSIRLDLEALFRFSHLILTFKTFRPAAMLVERStDYGHNWKVFKYFAKDCATSFPNITSG--QAQ 176
Cdd:smart00136   74 T-WWQSEPlsnGPQNVNLTLDLGKEFHVTYVILKFCSPRPSLWILERS-DFGKTWQPWQYFSSDCRRTFGRPPRGpiTKG 151

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613146   177 GVGDIVCDSKYSDIEPSTGGEVVLKVLDPSFEIEN-PYSPYIQDLVTLTNLRINFTKLHTLGDALLGRRQNDsLDKYYYA 255
Cdd:smart00136  152 NEDEVICTSEYSDIVPLEGGEIAFSLLEGRPSATDfDNSPVLQEWVTATNIRVRLTRLRTLGDELMDDRPEV-TRRYYYA 230


                    ....*...
gi 2462613146   256 LYEMIVRG 263
Cdd:smart00136  231 ISDIAVGG 238
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 1080-1128 4.02e-12

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 62.37  E-value: 4.02e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 2462613146 1080 CDCDPRTSQSSHCDQLTGQCPCKLGYGGKRCSECQENYYGDPPGRCIPC 1128
Cdd:pfam00053    1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 454-503 4.47e-11

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 59.29  E-value: 4.47e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 2462613146  454 PCDCNPLGSLPFlTCDVDTGQCLCLSYVTGAHCEECTVGYWGLGNHLHGC 503
Cdd:cd00055      1 PCDCNGHGSLSG-QCDPGTGQCECKPNTTGRRCDRCAPGYYGLPSQGGGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 505-549 9.05e-11

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 58.52  E-value: 9.05e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 2462613146  505 PCDCDIGGAYSNVCSPKNGQCECRPHVTGRSCSEPAPGYFFAPLN 549
Cdd:cd00055      1 PCDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLPSQ 45
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
1080-1125 9.69e-11

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 58.09  E-value: 9.69e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 2462613146  1080 CDCDPRTSQSSHCDQLTGQCPCKLGYGGKRCSECQENYYGDPPGRC 1125
Cdd:smart00180    1 CDCDPGGSASGTCDPDTGQCECKPNVTGRRCDRCAPGYYGDGPPGC 46
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 395-452 1.82e-10

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 57.36  E-value: 1.82e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 2462613146  395 CECDPDGTiSGGICVSHSdpalgsvaGQCLCKENVEGAKCDQCKPNHYGLSATDPLGC 452
Cdd:pfam00053    1 CDCNPHGS-LSDTCDPET--------GQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 1079-1121 5.01e-10

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 56.21  E-value: 5.01e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 2462613146 1079 SCDCDPRTSQSSHCDQLTGQCPCKLGYGGKRCSECQENYYGDP 1121
Cdd:cd00055      1 PCDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLP 43
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 1127-1176 5.26e-10

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 56.21  E-value: 5.26e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 2462613146 1127 PCDCNRAGTQKPICDPDTGMCRCREGVSGQRCDRCARGHSQEFPTCLQCH 1176
Cdd:cd00055      1 PCDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLPSQGGGCQ 50
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 455-508 7.37e-10

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 55.82  E-value: 7.37e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2462613146  455 CDCNPLGSLPFlTCDVDTGQCLCLSYVTGAHCEECTVGYWGlgnhLHGCSPCDC 508
Cdd:pfam00053    1 CDCNPHGSLSD-TCDPETGQCLCKPGVTGRHCDRCKPGYYG----LPSDPPQGC 49
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 822-865 1.02e-09

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 55.44  E-value: 1.02e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 2462613146  822 QGSKDTVCDQVTGQCPCHGEVSGRRCDRCLAGYFGFPSCHPCPC 865
Cdd:pfam00053    6 HGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
506-549 1.64e-09

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 54.62  E-value: 1.64e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 2462613146   506 CDCDIGGAYSNVCSPKNGQCECRPHVTGRSCSEPAPGYFFAPLN 549
Cdd:smart00180    1 CDCDPGGSASGTCDPDTGQCECKPNVTGRRCDRCAPGYYGDGPP 44
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
1128-1172 2.49e-09

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 54.24  E-value: 2.49e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 2462613146  1128 CDCNRAGTQKPICDPDTGMCRCREGVSGQRCDRCARGHSQE-FPTC 1172
Cdd:smart00180    1 CDCDPGGSASGTCDPDTGQCECKPNVTGRRCDRCAPGYYGDgPPGC 46
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 394-453 7.53e-09

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 53.13  E-value: 7.53e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613146  394 PCECDPDGTISGGiCVSHSdpalgsvaGQCLCKENVEGAKCDQCKPNHYGLsATDPLGCQ 453
Cdd:cd00055      1 PCDCNGHGSLSGQ-CDPGT--------GQCECKPNTTGRRCDRCAPGYYGL-PSQGGGCQ 50
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 1128-1165 8.52e-09

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 52.74  E-value: 8.52e-09
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2462613146 1128 CDCNRAGTQKPICDPDTGMCRCREGVSGQRCDRCARGH 1165
Cdd:pfam00053    1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGY 38
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
455-503 1.19e-08

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 52.31  E-value: 1.19e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*....
gi 2462613146   455 CDCNPLGSLPFlTCDVDTGQCLCLSYVTGAHCEECTVGYWglGNHLHGC 503
Cdd:smart00180    1 CDCDPGGSASG-TCDPDTGQCECKPNVTGRRCDRCAPGYY--GDGPPGC 46
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 768-809 1.47e-08

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 51.97  E-value: 1.47e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2462613146  768 ACKCHPQGSVGSSCSRLGGQCQCKPLVVGRCCDRCSTGSYDL 809
Cdd:cd00055      1 PCDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGL 42
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 769-809 1.71e-08

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 51.97  E-value: 1.71e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 2462613146  769 CKCHPQGSVGSSCSRLGGQCQCKPLVVGRCCDRCSTGSYDL 809
Cdd:pfam00053    1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGL 41
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 1033-1077 2.53e-08

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 51.59  E-value: 2.53e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 2462613146 1033 ECPPGGGACL-CDPVTGACPCLPNVTGLACDRCADGYWNLV--PGRGC 1077
Cdd:pfam00053    2 DCNPHGSLSDtCDPETGQCLCKPGVTGRHCDRCKPGYYGLPsdPPQGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 1021-1078 3.12e-08

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 51.20  E-value: 3.12e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462613146 1021 RCSCHASGVSPMECppgggaclcDPVTGACPCLPNVTGLACDRCADGYWNL-VPGRGCQ 1078
Cdd:cd00055      1 PCDCNGHGSLSGQC---------DPGTGQCECKPNTTGRRCDRCAPGYYGLpSQGGGCQ 50
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 822-859 5.50e-08

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 50.43  E-value: 5.50e-08
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2462613146  822 QGSKDTVCDQVTGQCPCHGEVSGRRCDRCLAGYFGFPS 859
Cdd:cd00055      7 HGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLPS 44
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
1022-1077 8.30e-08

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 50.00  E-value: 8.30e-08
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462613146  1022 CSCHASGVSPMECppgggaclcDPVTGACPCLPNVTGLACDRCADGYWNlVPGRGC 1077
Cdd:smart00180    1 CDCDPGGSASGTC---------DPDTGQCECKPNVTGRRCDRCAPGYYG-DGPPGC 46
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
395-448 1.22e-07

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 49.62  E-value: 1.22e-07
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....
gi 2462613146   395 CECDPDGTISGGiCVSHSdpalgsvaGQCLCKENVEGAKCDQCKPNHYGLSATD 448
Cdd:smart00180    1 CDCDPGGSASGT-CDPDT--------GQCECKPNVTGRRCDRCAPGYYGDGPPG 45
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 862-909 2.37e-07

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 48.89  E-value: 2.37e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2462613146  862 PCPCNRFAEL---CDPETGSCFnCGGFTTGRNCERCIDGYYGNPSSGQPCR 909
Cdd:cd00055      1 PCDCNGHGSLsgqCDPGTGQCE-CKPNTTGRRCDRCAPGYYGLPSQGGGCQ 50
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
769-808 2.75e-07

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 48.46  E-value: 2.75e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 2462613146   769 CKCHPQGSVGSSCSRLGGQCQCKPLVVGRCCDRCSTGSYD 808
Cdd:smart00180    1 CDCDPGGSASGTCDPDTGQCECKPNVTGRRCDRCAPGYYG 40
HEC1 COG5185
Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell ...
 1250-1495 7.05e-07

Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 444066 [Multi-domain]  Cd Length: 594  Bit Score: 53.81  E-value: 7.05e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613146 1250 SVRRQIMQLNEQLKAVYEFQdlkdTIERAKNEADLLLEDLQEEIDLQSSVLNASIADSSENIKKYYHIS--SSAEKKINE 1327
Cdd:COG5185    306 DIKKATESLEEQLAAAEAEQ----ELEESKRETETGIQNLTAEIEQGQESLTENLEAIKEEIENIVGEVelSKSSEELDS 381

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613146 1328 TSSTINTsanTRNDLLTILDTLTSKGNLSLERL-KQIKIPDIQI--LNEKVCGDPGNVPCVPLPCGGALCTGRKGHRKCR 1404
Cdd:COG5185    382 FKDTIES---TKESLDEIPQNQRGYAQEILATLeDTLKAADRQIeeLQRQIEQATSSNEEVSKLLNELISELNKVMREAD 458

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613146 1405 GpgchGSLTLSTNALQK-AQEAKSIIRNLDKQVRGLKNQIESISEQAEVSKNNalqLREKLGNIRNQSDSEEENINLFIK 1483
Cdd:COG5185    459 E----ESQSRLEEAYDEiNRSVRSKKEDLNEELTQIESRVSTLKATLEKLRAK---LERQLEGVRSKLDQVAESLKDFMR 531

                          250
                   ....*....|..
gi 2462613146 1484 KVKNFLLEENVP 1495
Cdd:COG5185    532 ARGYAHILALEN 543
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
822-858 8.73e-07

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 46.92  E-value: 8.73e-07
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 2462613146   822 QGSKDTVCDQVTGQCPCHGEVSGRRCDRCLAGYFGFP 858
Cdd:smart00180    6 GGSASGTCDPDTGQCECKPNVTGRRCDRCAPGYYGDG 42
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 264-320 2.13e-06

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 46.19  E-value: 2.13e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613146  264 SCFCNGHAS---ECRPmqkmrgdvfsppgmVHGQCVCQHNTDGPNCERCKDFFQDAPWRP 320
Cdd:cd00055      1 PCDCNGHGSlsgQCDP--------------GTGQCECKPNTTGRRCDRCAPGYYGLPSQG 46
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 970-1012 2.48e-06

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 45.81  E-value: 2.48e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 2462613146  970 CACNNNIDVTDpeSCSRVTGECLrCLHNTQGANCQLCKPGHYG 1012
Cdd:pfam00053    1 CDCNPHGSLSD--TCDPETGQCL-CKPGVTGRHCDRCKPGYYG 40
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 969-1016 3.04e-06

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 45.42  E-value: 3.04e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 2462613146  969 PCACNNNIDVtdPESCSRVTGECLrCLHNTQGANCQLCKPGHYGSALN 1016
Cdd:cd00055      1 PCDCNGHGSL--SGQCDPGTGQCE-CKPNTTGRRCDRCAPGYYGLPSQ 45
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 506-544 4.98e-06

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 45.04  E-value: 4.98e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 2462613146  506 CDCDIGGAYSNVCSPKNGQCECRPHVTGRSCSEPAPGYF 544
Cdd:pfam00053    1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYY 39
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 332-382 2.31e-05

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 43.11  E-value: 2.31e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2462613146  332 CSCNSHSS---RCHFdmttylasgglSGGVCeDCQHNTEGQHCDRCRPLFYRDP 382
Cdd:pfam00053    1 CDCNPHGSlsdTCDP-----------ETGQC-LCKPGVTGRHCDRCKPGYYGLP 42
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 331-384 2.96e-05

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 42.73  E-value: 2.96e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462613146  331 SCSCNSHSS---RCHFDmttylasgglsGGVCEdCQHNTEGQHCDRCRPLFYRDPLK 384
Cdd:cd00055      1 PCDCNGHGSlsgQCDPG-----------TGQCE-CKPNTTGRRCDRCAPGYYGLPSQ 45
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 1248-1555 5.24e-05

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 48.09  E-value: 5.24e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613146 1248 HDSVRRQIMQLNEQlkavyeFQDLKDTIERAKNEadllLEDLQEEID-LQSSVLNASiaDSSENIKKyyhissSAEKKIN 1326
Cdd:TIGR04523  213 NKSLESQISELKKQ------NNQLKDNIEKKQQE----INEKTTEISnTQTQLNQLK--DEQNKIKK------QLSEKQK 274

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613146 1327 EtsstINTSANTRNDLLTILDTLTSKgnlsLERLKQIKIPDI-QILNEKVcgdpgnvpcvplpcggalctgrkghrkcrg 1405
Cdd:TIGR04523  275 E----LEQNNKKIKELEKQLNQLKSE----ISDLNNQKEQDWnKELKSEL------------------------------ 316

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613146 1406 pgchgsltlsTNALQKAQEAKSIIRNLDKQVRGLKNQIESISEQAEVSKNNAL----QLREK---LGNIRNQSDSEEENI 1478
Cdd:TIGR04523  317 ----------KNQEKKLEEIQNQISQNNKIISQLNEQISQLKKELTNSESENSekqrELEEKqneIEKLKKENQSYKQEI 386

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613146 1479 NLFIKKVKNflLEENVppEDIEKVANgVLDIHLpipsQNLTDELVKIQKHMQLCEDYRTDEN----RLNEEaDGAQKLLV 1554
Cdd:TIGR04523  387 KNLESQIND--LESKI--QNQEKLNQ-QKDEQI----KKLQQEKELLEKEIERLKETIIKNNseikDLTNQ-DSVKELII 456


                   .
gi 2462613146 1555 K 1555
Cdd:TIGR04523  457 K 457
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 863-908 1.28e-04

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 41.18  E-value: 1.28e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 2462613146  863 CPCN---RFAELCDPETGSCFnCGGFTTGRNCERCIDGYYGNPS-SGQPC 908
Cdd:pfam00053    1 CDCNphgSLSDTCDPETGQCL-CKPGVTGRHCDRCKPGYYGLPSdPPQGC 49
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
1249-1563 1.78e-04

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 45.66  E-value: 1.78e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613146 1249 DSVRRQIMQLNEQLKAV-YEFQDLKDTIERAKNEADLLLEDLQE-EIDLQSSvlNASIADSSENIKKYYHISSSAEKKIN 1326
Cdd:COG4372     41 DKLQEELEQLREELEQArEELEQLEEELEQARSELEQLEEELEElNEQLQAA--QAELAQAQEELESLQEEAEELQEELE 118

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613146 1327 ETSSTINTSANTRNDLLTILDTLTSKGNLSLERLKQIKIpDIQILNEKVcgdpgnvpcvplpcggalctgrkghrkcrgp 1406
Cdd:COG4372    119 ELQKERQDLEQQRKQLEAQIAELQSEIAEREEELKELEE-QLESLQEEL------------------------------- 166

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613146 1407 gchGSLTLSTNALQKAQeaksIIRNLDKQVRGLKNQIESISEQAEVSKNNALQLREKLGNIRNQSDSEEENINLFIKKVK 1486
Cdd:COG4372    167 ---AALEQELQALSEAE----AEQALDELLKEANRNAEKEEELAEAEKLIESLPRELAEELLEAKDSLEAKLGLALSALL 239

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462613146 1487 NFLLEENVPPEDIEKVANGVLDIHLPIPSQNLTDELVKIqkhmqlcEDYRTDENRLNEEADGAQKLLVKAKAAENLL 1563
Cdd:COG4372    240 DALELEEDKEELLEEVILKEIEELELAILVEKDTEEEEL-------EIAALELEALEEAALELKLLALLLNLAALSL 309
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
972-1013 5.55e-04

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 39.22  E-value: 5.55e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 2462613146   972 CNNNIDVTDPESCSRVTGECLrCLHNTQGANCQLCKPGHYGS 1013
Cdd:smart00180    1 CDCDPGGSASGTCDPDTGQCE-CKPNVTGRRCDRCAPGYYGD 41
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
863-905 5.88e-04

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 39.22  E-value: 5.88e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 2462613146   863 CPCNR---FAELCDPETGSCfNCGGFTTGRNCERCIDGYYGNPSSG 905
Cdd:smart00180    1 CDCDPggsASGTCDPDTGQC-ECKPNVTGRRCDRCAPGYYGDGPPG 45
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
332-382 5.88e-04

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 39.22  E-value: 5.88e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....
gi 2462613146   332 CSCN---SHSSRCHFDmttylasgglsGGVCEdCQHNTEGQHCDRCRPLFYRDP 382
Cdd:smart00180    1 CDCDpggSASGTCDPD-----------TGQCE-CKPNVTGRRCDRCAPGYYGDG 42
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 265-323 1.08e-03

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 38.49  E-value: 1.08e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462613146  265 CFCNGHAS---ECRPMQkmrgdvfsppgmvhGQCVCQHNTDGPNCERCKDFFQDAPWRPAAD 323
Cdd:pfam00053    1 CDCNPHGSlsdTCDPET--------------GQCLCKPGVTGRHCDRCKPGYYGLPSDPPQG 48
PRK04778 PRK04778
septation ring formation regulator EzrA; Provisional
 1242-1563 1.31e-03

septation ring formation regulator EzrA; Provisional


Pssm-ID: 179877 [Multi-domain]  Cd Length: 569  Bit Score: 43.29  E-value: 1.31e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613146 1242 LKVKDY---HDSVRRQIMQLNEQLKAVYEfqDLKDT-IERAKNEadllLEDLQEEIDLQSSVLNASIAdssenikkyyhi 1317
Cdd:PRK04778   242 LVEEGYhldHLDIEKEIQDLKEQIDENLA--LLEELdLDEAEEK----NEEIQERIDQLYDILEREVK------------ 303

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613146 1318 sssAEKKINETSSTINTS---ANTRNDLLTildtltskgnLSLERLKQikipdiqilnekvcgdpgnvpcvplpcggalc 1394
Cdd:PRK04778   304 ---ARKYVEKNSDTLPDFlehAKEQNKELK----------EEIDRVKQ-------------------------------- 338

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613146 1395 tgrkghrkcrgpgchgSLTLSTNALQKAQEAKSIIRNLDKQVRG--------------LKNQIESISEQAEVSKNNALQL 1460
Cdd:PRK04778   339 ----------------SYTLNESELESVRQLEKQLESLEKQYDEiteriaeqeiayseLQEELEEILKQLEEIEKEQEKL 402

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613146 1461 REKLGNIRNQSDSEEENINLFIKK---VKNFLLEENVP--PEDI----EKVANGVldihlpipsQNLTDELVKIQKHM-- 1529
Cdd:PRK04778   403 SEMLQGLRKDELEAREKLERYRNKlheIKRYLEKSNLPglPEDYlemfFEVSDEI---------EALAEELEEKPINMea 473

                          330       340       350
                   ....*....|....*....|....*....|....*.
gi 2462613146 1530 --QLCEDYRTDENRLNEEADgaqKLLVKAKAAENLL 1563
Cdd:PRK04778   474 vnRLLEEATEDVETLEEETE---ELVENATLTEQLI 506
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
291-313 1.48e-03

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 38.06  E-value: 1.48e-03
                            10        20
                    ....*....|....*....|...
gi 2462613146   291 VHGQCVCQHNTDGPNCERCKDFF 313
Cdd:smart00180   16 DTGQCECKPNVTGRRCDRCAPGY 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH