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Conserved domains on  [gi|2462615926|ref|XP_054214890|]
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radial spoke head 10 homolog B2 isoform X7 [Homo sapiens]

Protein Classification

MORN repeat-containing protein( domain architecture ID 11468649)

membrane-occupation-and-recognition-nexus (MORN) repeat-containing protein may be involved in protein-protein interactions

PubMed:  33296386|35568981

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
4-128 1.79e-35

Uncharacterized conserved protein [Function unknown];


:

Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 135.08  E-value: 1.79e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615926   4 GTGSYKSGNIYEGQWEDNMRHGEGRMRWlTTNEEYTGRWERGIQNGFGTHTWflkrirssqyPLRNEYIGEFVNGYRHGR 83
Cdd:COG4642   140 GIYTFPNGDVYEGEFKNGKPHGQGTLTY-ADGDRYEGEFKNGKRHGQGTLTY----------ANGDVYEGEFKNGQRHGQ 208

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 2462615926  84 GKFYYASGAMYDGEWVSNKKHGMGRLTFKNGRVYEGAFSNDHIAG 128
Cdd:COG4642   209 GTYTYADGDRYEGEFKNGKRHGQGTLTYADGDRYEGEFKNGKRHG 253
 
Name Accession Description Interval E-value
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
4-128 1.79e-35

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 135.08  E-value: 1.79e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615926   4 GTGSYKSGNIYEGQWEDNMRHGEGRMRWlTTNEEYTGRWERGIQNGFGTHTWflkrirssqyPLRNEYIGEFVNGYRHGR 83
Cdd:COG4642   140 GIYTFPNGDVYEGEFKNGKPHGQGTLTY-ADGDRYEGEFKNGKRHGQGTLTY----------ANGDVYEGEFKNGQRHGQ 208

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 2462615926  84 GKFYYASGAMYDGEWVSNKKHGMGRLTFKNGRVYEGAFSNDHIAG 128
Cdd:COG4642   209 GTYTYADGDRYEGEFKNGKRHGQGTLTYADGDRYEGEFKNGKRHG 253
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 11-121 7.56e-17

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 84.50  E-value: 7.56e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615926  11 GNIYEGQWEDNMRHGEGRMRWlTTNEEYTGRWERGIQNGFGTHTWflkrirssqyPLRNEYIGEFVNGYRHGRGKFYYAS 90
Cdd:PLN03185    8 GDFYSGSLLGNVPEGPGKYLW-SDGCMYEGEWRRGMRHGNGKISW----------PSGATYEGEFSGGYMHGSGTYTGTD 76

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2462615926  91 GAMYDGEWVSNKKHGMGRLTFKNGRVYEGAF 121
Cdd:PLN03185   77 GTTYKGRWRLNLKHGLGYQRYPNGDVFEGSW 107
MORN smart00698
Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;
12-31 2.17e-05

Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;


Pssm-ID: 197832 [Multi-domain]  Cd Length: 22  Bit Score: 41.56  E-value: 2.17e-05
                           10        20
                   ....*....|....*....|
gi 2462615926   12 NIYEGQWEDNMRHGEGRMRW 31
Cdd:smart00698   1 DRYEGEWRNGKRHGRGVYTY 20
MORN pfam02493
MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple ...
 71-93 4.44e-05

MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple copies in several proteins including junctophilins (See Takeshima et al. Mol. Cell 2000;6:11-22). A MORN-repeat protein has been identified in the parasite Toxoplasma gondiis a dynamic component of cell division apparatus in Toxoplasma gondii. It has been hypothesized to functions as a linker protein between certain membrane regions and the parasite's cytoskeleton.


Pssm-ID: 308220 [Multi-domain]  Cd Length: 23  Bit Score: 40.47  E-value: 4.44e-05
                          10        20
                  ....*....|....*....|...
gi 2462615926  71 YIGEFVNGYRHGRGKFYYASGAM 93
Cdd:pfam02493   1 YEGEWKNGKRHGKGVYTWPDGDR 23
 
Name Accession Description Interval E-value
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
4-128 1.79e-35

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 135.08  E-value: 1.79e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615926   4 GTGSYKSGNIYEGQWEDNMRHGEGRMRWlTTNEEYTGRWERGIQNGFGTHTWflkrirssqyPLRNEYIGEFVNGYRHGR 83
Cdd:COG4642   140 GIYTFPNGDVYEGEFKNGKPHGQGTLTY-ADGDRYEGEFKNGKRHGQGTLTY----------ANGDVYEGEFKNGQRHGQ 208

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 2462615926  84 GKFYYASGAMYDGEWVSNKKHGMGRLTFKNGRVYEGAFSNDHIAG 128
Cdd:COG4642   209 GTYTYADGDRYEGEFKNGKRHGQGTLTYADGDRYEGEFKNGKRHG 253
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
4-123 5.93e-34

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 130.85  E-value: 5.93e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615926   4 GTGSYKSGNIYEGQWEDNMRHGEGRMRWlTTNEEYTGRWERGIQNGFGTHTWflkrirssqyPLRNEYIGEFVNGYRHGR 83
Cdd:COG4642   163 GTLTYADGDRYEGEFKNGKRHGQGTLTY-ANGDVYEGEFKNGQRHGQGTYTY----------ADGDRYEGEFKNGKRHGQ 231

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 2462615926  84 GKFYYASGAMYDGEWVSNKKHGMGRLTFKNGRVYEGAFSN 123
Cdd:COG4642   232 GTLTYADGDRYEGEFKNGKRHGQGTMTYADGSVYEGEWKN 271
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
4-129 8.13e-24

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 101.57  E-value: 8.13e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615926   4 GTGSYKSGNIYEGQWEDNMRHGEGRMRWLTTNEEYTGRWERGIQNGFG---------THTWFLKRIRSSQ----YPLRNE 70
Cdd:COG4642    70 GGVTAAGGGGGGGGGKGDGGDGGGGEGGFGGGGGGGGGKKGGGGGGGGvlegddgggYGGGTADGGRGGGgiytFPNGDV 149

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462615926  71 YIGEFVNGYRHGRGKFYYASGAMYDGEWVSNKKHGMGRLTFKNGRVYEGAFSNDHIAGF 129
Cdd:COG4642   150 YEGEFKNGKPHGQGTLTYADGDRYEGEFKNGKRHGQGTLTYANGDVYEGEFKNGQRHGQ 208
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 11-121 7.56e-17

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 84.50  E-value: 7.56e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615926  11 GNIYEGQWEDNMRHGEGRMRWlTTNEEYTGRWERGIQNGFGTHTWflkrirssqyPLRNEYIGEFVNGYRHGRGKFYYAS 90
Cdd:PLN03185    8 GDFYSGSLLGNVPEGPGKYLW-SDGCMYEGEWRRGMRHGNGKISW----------PSGATYEGEFSGGYMHGSGTYTGTD 76

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2462615926  91 GAMYDGEWVSNKKHGMGRLTFKNGRVYEGAF 121
Cdd:PLN03185   77 GTTYKGRWRLNLKHGLGYQRYPNGDVFEGSW 107
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 4-122 2.08e-16

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 83.34  E-value: 2.08e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615926   4 GTGSY--KSGNIYEGQWEDNMRHGEGRMRWlTTNEEYTGRWERGIQNGFGTHTWflkrirssqyPLRNEYIGEFVNGYRH 81
Cdd:PLN03185   68 GSGTYtgTDGTTYKGRWRLNLKHGLGYQRY-PNGDVFEGSWIQGLQEGPGKYTW----------ANGNVYLGDMKGGKMS 136

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2462615926  82 GRGKFYYASGAMYDGEWVSNKKHGMGRLTFKNGRVYEGAFS 122
Cdd:PLN03185  137 GKGTLTWVSGDSYEGQWLDGMMHGFGVYTWSDGGCYVGTWT 177
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 4-129 2.77e-15

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 79.49  E-value: 2.77e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615926   4 GTGSY--KSGNIYEGQWEDNMRHGEGRMRWlTTNEEYTGRWERGIQNGFGTHT----------WFLKR---IRSSQYPLR 68
Cdd:PLN03185   22 GPGKYlwSDGCMYEGEWRRGMRHGNGKISW-PSGATYEGEFSGGYMHGSGTYTgtdgttykgrWRLNLkhgLGYQRYPNG 100

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462615926  69 NEYIGEFVNGYRHGRGKFYYASGAMYDGEWVSNKKHGMGRLTFKNGRVYEGAFSNDHIAGF 129
Cdd:PLN03185  101 DVFEGSWIQGLQEGPGKYTWANGNVYLGDMKGGKMSGKGTLTWVSGDSYEGQWLDGMMHGF 161
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 4-107 3.57e-11

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 66.40  E-value: 3.57e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615926   4 GTGSYKSGNIYEGQWEDNMRHGEGRMRWLTTNEeYTGRWERGIQNGFGTHTWFLKrirssqyplrNEYIGEFVNGYRHGR 83
Cdd:PLN03185   93 GYQRYPNGDVFEGSWIQGLQEGPGKYTWANGNV-YLGDMKGGKMSGKGTLTWVSG----------DSYEGQWLDGMMHGF 161

                          90       100
                  ....*....|....*....|....
gi 2462615926  84 GKFYYASGAMYDGEWVSNKKHGMG 107
Cdd:PLN03185  162 GVYTWSDGGCYVGTWTRGLKDGKG 185
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
4-129 2.04e-10

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 61.90  E-value: 2.04e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615926   4 GTGSYKSGNIYEGQWEDNMRHGEGRMRWLTTNEEYTGRWERGIQNGFGTHTWFLKRIRSSQY--PLRNEYIGEFVNGYRH 81
Cdd:COG4642    35 GGLGTLPGGGGYGGGADGGGGGGGGTGVAGGGGGEGGVTAAGGGGGGGGGKGDGGDGGGGEGgfGGGGGGGGGKKGGGGG 114

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2462615926  82 GRGKFYYASGAMYDGEWVSNKKHGMGRLTFKNGRVYEGAFSNDHIAGF 129
Cdd:COG4642   115 GGGVLEGDDGGGYGGGTADGGRGGGGIYTFPNGDVYEGEFKNGKPHGQ 162
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 66-129 1.19e-08

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 58.31  E-value: 1.19e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462615926  66 PLRNEYIGEFVNGYRHGRGKFYYASGAMYDGEWVSNKKHGMGRLTFKNGRVYEGAFSNDHIAGF 129
Cdd:PLN03185    6 SNGDFYSGSLLGNVPEGPGKYLWSDGCMYEGEWRRGMRHGNGKISWPSGATYEGEFSGGYMHGS 69
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 4-87 1.45e-06

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 51.37  E-value: 1.45e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615926   4 GTGSY--KSGNIYEGQWEDNMRHGEGRMRWlTTNEEYTGRWERGIQNGFGTHTWflkrirssqyplrNE---YIGEFVNG 78
Cdd:PLN03185  114 GPGKYtwANGNVYLGDMKGGKMSGKGTLTW-VSGDSYEGQWLDGMMHGFGVYTW-------------SDggcYVGTWTRG 179


                  ....*....
gi 2462615926  79 YRHGRGKFY 87
Cdd:PLN03185  180 LKDGKGVFY 188
YwqK COG2849
Antitoxin component YwqK of the YwqJK toxin-antitoxin module [Defense mechanisms];
8-124 1.42e-05

Antitoxin component YwqK of the YwqJK toxin-antitoxin module [Defense mechanisms];


Pssm-ID: 442097 [Multi-domain]  Cd Length: 163  Bit Score: 45.83  E-value: 1.42e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615926   8 YKSGNI-YEGQWEDNMRHGEGRMRWlttneeytgrwergiQNGfgthtwflkRIRSsqyplrneyIGEFVNGYRHGRGKF 86
Cdd:COG2849    74 YPNGQLkSEGTYKNGKLEGEWKEYY---------------ENG---------KLKS---------EGNYKNGKLHGEWKE 120

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 2462615926  87 YYASGA-MYDGEWVSNKKHGMGRLTFKNGR-VYEGAFSND 124
Cdd:COG2849   121 YYENGKlKEEGNYKNGKKDGVWKYYDENGKlVKEEEYKNG 160
MORN smart00698
Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;
12-31 2.17e-05

Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;


Pssm-ID: 197832 [Multi-domain]  Cd Length: 22  Bit Score: 41.56  E-value: 2.17e-05
                           10        20
                   ....*....|....*....|
gi 2462615926   12 NIYEGQWEDNMRHGEGRMRW 31
Cdd:smart00698   1 DRYEGEWRNGKRHGRGVYTY 20
YwqK COG2849
Antitoxin component YwqK of the YwqJK toxin-antitoxin module [Defense mechanisms];
70-128 3.80e-05

Antitoxin component YwqK of the YwqJK toxin-antitoxin module [Defense mechanisms];


Pssm-ID: 442097 [Multi-domain]  Cd Length: 163  Bit Score: 44.67  E-value: 3.80e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462615926  70 EYIGEFVNGYRHGRGKFYYASGAM-YDGEWVSNKKHGMGRLTFKNGRV-YEGAFSNDHIAG 128
Cdd:COG2849    80 KSEGTYKNGKLEGEWKEYYENGKLkSEGNYKNGKLHGEWKEYYENGKLkEEGNYKNGKKDG 140
MORN pfam02493
MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple ...
 71-93 4.44e-05

MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple copies in several proteins including junctophilins (See Takeshima et al. Mol. Cell 2000;6:11-22). A MORN-repeat protein has been identified in the parasite Toxoplasma gondiis a dynamic component of cell division apparatus in Toxoplasma gondii. It has been hypothesized to functions as a linker protein between certain membrane regions and the parasite's cytoskeleton.


Pssm-ID: 308220 [Multi-domain]  Cd Length: 23  Bit Score: 40.47  E-value: 4.44e-05
                          10        20
                  ....*....|....*....|...
gi 2462615926  71 YIGEFVNGYRHGRGKFYYASGAM 93
Cdd:pfam02493   1 YEGEWKNGKRHGKGVYTWPDGDR 23
MORN smart00698
Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;
69-89 2.32e-04

Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;


Pssm-ID: 197832 [Multi-domain]  Cd Length: 22  Bit Score: 38.48  E-value: 2.32e-04
                           10        20
                   ....*....|....*....|.
gi 2462615926   69 NEYIGEFVNGYRHGRGKFYYA 89
Cdd:smart00698   1 DRYEGEWRNGKRHGRGVYTYA 21
MORN pfam02493
MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple ...
 94-114 2.91e-04

MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple copies in several proteins including junctophilins (See Takeshima et al. Mol. Cell 2000;6:11-22). A MORN-repeat protein has been identified in the parasite Toxoplasma gondiis a dynamic component of cell division apparatus in Toxoplasma gondii. It has been hypothesized to functions as a linker protein between certain membrane regions and the parasite's cytoskeleton.


Pssm-ID: 308220 [Multi-domain]  Cd Length: 23  Bit Score: 38.16  E-value: 2.91e-04
                          10        20
                  ....*....|....*....|.
gi 2462615926  94 YDGEWVSNKKHGMGRLTFKNG 114
Cdd:pfam02493   1 YEGEWKNGKRHGKGVYTWPDG 21
MORN smart00698
Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;
92-113 3.21e-04

Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;


Pssm-ID: 197832 [Multi-domain]  Cd Length: 22  Bit Score: 38.09  E-value: 3.21e-04
                           10        20
                   ....*....|....*....|..
gi 2462615926   92 AMYDGEWVSNKKHGMGRLTFKN 113
Cdd:smart00698   1 DRYEGEWRNGKRHGRGVYTYAN 22
MORN pfam02493
MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple ...
 14-31 6.57e-04

MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple copies in several proteins including junctophilins (See Takeshima et al. Mol. Cell 2000;6:11-22). A MORN-repeat protein has been identified in the parasite Toxoplasma gondiis a dynamic component of cell division apparatus in Toxoplasma gondii. It has been hypothesized to functions as a linker protein between certain membrane regions and the parasite's cytoskeleton.


Pssm-ID: 308220 [Multi-domain]  Cd Length: 23  Bit Score: 37.39  E-value: 6.57e-04
                          10
                  ....*....|....*...
gi 2462615926  14 YEGQWEDNMRHGEGRMRW 31
Cdd:pfam02493   1 YEGEWKNGKRHGKGVYTW 18
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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