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Conserved domains on  [gi|2462618867|ref|XP_054216208|]
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dynein axonemal assembly factor 11 isoform X6 [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1903219)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 29-161 9.51e-20

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd21340:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 220  Bit Score: 87.15  E-value: 9.51e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462618867  29 LEELSLHQQEIERLEHIDKwCRDLKILYLQNNLIGKIENVSKLKKLE------------------------------YLN 78
Cdd:cd21340    48 LTHLYLQNNQIEKIENLEN-LVNLKKLYLGGNRISVVEGLENLTNLEelhienqrlppgekltfdprslaalsnslrVLN 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462618867  79 LALNNIEKIENLEGCEELAKLDLTVNFIGELSSIKN-LQHNIHLKELFLMGNPCASFDHYREFVVATLPQLKWLDGKEIE 157
Cdd:cd21340   127 ISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELLDlLSSWPSLRELDLTGNPVCKKPKYRDKIILASKSLEVLDGKEIT 206


                  ....
gi 2462618867 158 PSER 161
Cdd:cd21340   207 DTER 210
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 29-161 9.51e-20

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 87.15  E-value: 9.51e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462618867  29 LEELSLHQQEIERLEHIDKwCRDLKILYLQNNLIGKIENVSKLKKLE------------------------------YLN 78
Cdd:cd21340    48 LTHLYLQNNQIEKIENLEN-LVNLKKLYLGGNRISVVEGLENLTNLEelhienqrlppgekltfdprslaalsnslrVLN 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462618867  79 LALNNIEKIENLEGCEELAKLDLTVNFIGELSSIKN-LQHNIHLKELFLMGNPCASFDHYREFVVATLPQLKWLDGKEIE 157
Cdd:cd21340   127 ISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELLDlLSSWPSLRELDLTGNPVCKKPKYRDKIILASKSLEVLDGKEIT 206


                  ....
gi 2462618867 158 PSER 161
Cdd:cd21340   207 DTER 210
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
28-152 1.68e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 59.18  E-value: 1.68e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462618867  28 SLEELSLHQQEIERLEHIDKWCRDLKILYLQNNLIGKI-ENVSKLKKLEYLNLALNNIEKI-ENLEGCEELAKLDLTVNF 105
Cdd:COG4886   114 NLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLpEPLGNLTNLKSLDLSNNQLTDLpEELGNLTNLKELDLSNNQ 193

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2462618867 106 IGELS-SIKNLQhniHLKELFLMGNPCASFDHyrefVVATLPQLKWLD 152
Cdd:COG4886   194 ITDLPePLGNLT---NLEELDLSGNQLTDLPE----PLANLTNLETLD 234
LRR_9 pfam14580
Leucine-rich repeat;
31-166 9.52e-09

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 54.38  E-value: 9.52e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462618867  31 ELSLHQQEIERLEHIDKWCRDLKILYLQNNLIGKIENVSKLKKLEYLNLALNNIEKIEnlEGCEE----LAKLDLTVNFI 106
Cdd:pfam14580  23 ELDLRGYKIPIIENLGATLDQFDTIDFSDNEIRKLDGFPLLRRLKTLLLNNNRICRIG--EGLGEalpnLTELILTNNNL 100

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462618867 107 GELSSIKNLQHNIHLKELFLMGNPCASFDHYREFVVATLPQLKWLDGKEIEPSERIKALQ 166
Cdd:pfam14580 101 QELGDLDPLASLKKLTFLSLLRNPVTNKPHYRLYVIYKVPQLRLLDFRKVKQKERQAAEK 160
LRRcap smart00446
occurring C-terminal to leucine-rich repeats; A motif occurring C-terminal to leucine-rich ...
 134-152 2.98e-04

occurring C-terminal to leucine-rich repeats; A motif occurring C-terminal to leucine-rich repeats in "sds22-like" and "typical" LRR-containing proteins.


Pssm-ID: 197729  Cd Length: 19  Bit Score: 37.67  E-value: 2.98e-04
                           10
                   ....*....|....*....
gi 2462618867  134 FDHYREFVVATLPQLKWLD 152
Cdd:smart00446   1 LAHYREKVIELLPQLRKLD 19
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 29-161 9.51e-20

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 87.15  E-value: 9.51e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462618867  29 LEELSLHQQEIERLEHIDKwCRDLKILYLQNNLIGKIENVSKLKKLE------------------------------YLN 78
Cdd:cd21340    48 LTHLYLQNNQIEKIENLEN-LVNLKKLYLGGNRISVVEGLENLTNLEelhienqrlppgekltfdprslaalsnslrVLN 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462618867  79 LALNNIEKIENLEGCEELAKLDLTVNFIGELSSIKN-LQHNIHLKELFLMGNPCASFDHYREFVVATLPQLKWLDGKEIE 157
Cdd:cd21340   127 ISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELLDlLSSWPSLRELDLTGNPVCKKPKYRDKIILASKSLEVLDGKEIT 206


                  ....
gi 2462618867 158 PSER 161
Cdd:cd21340   207 DTER 210
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
28-152 1.68e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 59.18  E-value: 1.68e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462618867  28 SLEELSLHQQEIERLEHIDKWCRDLKILYLQNNLIGKI-ENVSKLKKLEYLNLALNNIEKI-ENLEGCEELAKLDLTVNF 105
Cdd:COG4886   114 NLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLpEPLGNLTNLKSLDLSNNQLTDLpEELGNLTNLKELDLSNNQ 193

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2462618867 106 IGELS-SIKNLQhniHLKELFLMGNPCASFDHyrefVVATLPQLKWLD 152
Cdd:COG4886   194 ITDLPePLGNLT---NLEELDLSGNQLTDLPE----PLANLTNLETLD 234
LRR_9 pfam14580
Leucine-rich repeat;
31-166 9.52e-09

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 54.38  E-value: 9.52e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462618867  31 ELSLHQQEIERLEHIDKWCRDLKILYLQNNLIGKIENVSKLKKLEYLNLALNNIEKIEnlEGCEE----LAKLDLTVNFI 106
Cdd:pfam14580  23 ELDLRGYKIPIIENLGATLDQFDTIDFSDNEIRKLDGFPLLRRLKTLLLNNNRICRIG--EGLGEalpnLTELILTNNNL 100

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462618867 107 GELSSIKNLQHNIHLKELFLMGNPCASFDHYREFVVATLPQLKWLDGKEIEPSERIKALQ 166
Cdd:pfam14580 101 QELGDLDPLASLKKLTFLSLLRNPVTNKPHYRLYVIYKVPQLRLLDFRKVKQKERQAAEK 160
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
28-166 8.91e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 53.78  E-value: 8.91e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462618867  28 SLEELSLHQQEIERLEHIDKWCRDLKILYLQNNLIGKIENVSKLKKLEYLNLALNNIEKIENLEGCEELAKLDLTVNFIG 107
Cdd:COG4886   206 NLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLT 285

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462618867 108 ELsSIKNLQHNIHLKELFLMGNPCASFDHYREFVVATLPQLKWLDGKEIEPSERIKALQ 166
Cdd:COG4886   286 DL-KLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALS 343
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 52-92 8.23e-06

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 42.62  E-value: 8.23e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 2462618867  52 LKILYLQNNLIGKIENVSKLKKLEYLNLALNN-IEKIENLEG 92
Cdd:pfam12799   3 LEVLDLSNNQITDIPPLAKLPNLETLDLSGNNkITDLSDLAN 44
LRR_8 pfam13855
Leucine rich repeat;
52-104 6.08e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.59  E-value: 6.08e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462618867  52 LKILYLQNNLIGKIENVS--KLKKLEYLNLALNNIEKIEN--LEGCEELAKLDLTVN 104
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAfkGLSNLKVLDLSNNLLTTLSPgaFSGLPSLRYLDLSGN 59
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
52-152 1.06e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 44.15  E-value: 1.06e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462618867  52 LKILYLQNNligkiENVSKLKKLEYLNLALNNIEKI-ENLEGCEELAKLDLTVNFIGEL-SSIKNLQhniHLKELFLMGN 129
Cdd:COG4886    98 LTELDLSGN-----EELSNLTNLESLDLSGNQLTDLpEELANLTNLKELDLSNNQLTDLpEPLGNLT---NLKSLDLSNN 169

                          90       100
                  ....*....|....*....|...
gi 2462618867 130 PCASFDHyrefVVATLPQLKWLD 152
Cdd:COG4886   170 QLTDLPE----ELGNLTNLKELD 188
LRRcap smart00446
occurring C-terminal to leucine-rich repeats; A motif occurring C-terminal to leucine-rich ...
 134-152 2.98e-04

occurring C-terminal to leucine-rich repeats; A motif occurring C-terminal to leucine-rich repeats in "sds22-like" and "typical" LRR-containing proteins.


Pssm-ID: 197729  Cd Length: 19  Bit Score: 37.67  E-value: 2.98e-04
                           10
                   ....*....|....*....
gi 2462618867  134 FDHYREFVVATLPQLKWLD 152
Cdd:smart00446   1 LAHYREKVIELLPQLRKLD 19
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 71-129 1.22e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 40.15  E-value: 1.22e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462618867  71 LKKLEYLNLALNNIEKIENLEGCEELAKLDLTVNFIgelSSIKNLQHNIHLKELFLMGN 129
Cdd:cd21340     1 LKRITHLYLNDKNITKIDNLSLCKNLKVLYLYDNKI---TKIENLEFLTNLTHLYLQNN 56
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 52-130 1.31e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 40.54  E-value: 1.31e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462618867  52 LKILYLQNNLIGK------IENVSKLKKLEYLNLALNNI------EKIENLEGCEELAKLDLTVNFIGELSSI---KNLQ 116
Cdd:COG5238   210 VTTLWLKRNPIGDegaeilAEALKGNKSLTTLDLSNNQIgdegviALAEALKNNTTVETLYLSGNQIGAEGAIalaKALQ 289

                          90
                  ....*....|....
gi 2462618867 117 HNIHLKELFLMGNP 130
Cdd:COG5238   290 GNTTLTSLDLSVNR 303
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 55-130 1.40e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 40.54  E-value: 1.40e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462618867  55 LYLQNNLIGK------IENVSKLKKLEYLNLALNNI------EKIENLEGCEELAKLDLTVNFIGELSSI---KNLQHNI 119
Cdd:COG5238   269 LYLSGNQIGAegaialAKALQGNTTLTSLDLSVNRIgdegaiALAEGLQGNKTLHTLNLAYNGIGAQGAIalaKALQENT 348

                          90
                  ....*....|.
gi 2462618867 120 HLKELFLMGNP 130
Cdd:COG5238   349 TLHSLDLSDNQ 359
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 72-114 1.86e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.07  E-value: 1.86e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 2462618867  72 KKLEYLNLALNNIEKIENLEGCEELAKLDLT-VNFIGELSSIKN 114
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSgNNKITDLSDLAN 44
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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