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Conserved domains on  [gi|2462625504|ref|XP_054219324|]
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DENN domain-containing protein 1A isoform X1 [Homo sapiens]

Protein Classification

DENN domain-containing protein( domain architecture ID 10655395)

DENN domain-containing protein may be involved in Rab-mediated processes or regulation of mitogen-activated protein kinase (MAPK) signalling pathways

CATH:  1.10.287.2550|3.40.50.11500|3.30.450.200
Gene Ontology:  GO:0005085|GO:0032483
PubMed:  21330364|11563850
SCOP:  4007417|4006687

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DENN smart00799
Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The ...
 113-291 1.02e-63

Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The DENN domain is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


:

Pssm-ID: 214823  Cd Length: 183  Bit Score: 213.60  E-value: 1.02e-63
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462625504   113 SCFCILSYLPWFEVFYKLLNILADYTTKRQENQwNELLETLHKLPIPDPG-----VSVHLSVHSYFTVPDTRELPSIPen 187
Cdd:smart00799    3 KCICILSRLPFFELFRKILNELYRLLPSSSNLP-LELLISLLLYPVPPPGgslvlVSLGPGDLIELQRPLDSSLPLID-- 79

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462625504   188 RNLTEYFVAVDVNNMLHLYASMLYERRILIICSKLSTLTACIHGSAAMLYPMYWQHVYIPVLPPHLLDYCCAPMPYLIGI 267
Cdd:smart00799   80 FSLHELFECLGVENILQLFAALLLERRIIFTSSNLSTLSAVIEALLALLYPFVWQHIYIPILPASLLDVLSAPTPFIIGV 159

                           170       180
                    ....*....|....*....|....
gi 2462625504   268 HLSLMEKVRNMALDDVVILNVDTN 291
Cdd:smart00799  160 HSSYFEEVKELPDEDVVVVDLDTG 183
uDENN smart00800
Domain always found upstream of DENN domain, found in a variety of signalling proteins; The ...
 48-109 2.56e-19

Domain always found upstream of DENN domain, found in a variety of signalling proteins; The uDENN domain is part of the tripartite DENN domain. It is always found upstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


:

Pssm-ID: 214824  Cd Length: 89  Bit Score: 83.54  E-value: 2.56e-19
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462625504    48 DPEVQRQFPE-DYSDQEVLQTLTKFCFPFYVD--SLTVSQVGQNFTFVLTDIDSKQRFGFCRLSS 109
Cdd:smart00800   25 KPEILQRYPEkDFEDFPLPDSIPLFCFPEGLDfvTQTSSKDPQFFSFVLTDIDGSRRYGFCLRFY 89
dDENN smart00801
Domain always found downstream of DENN domain, found in a variety of signalling proteins; The ...
 323-389 5.33e-17

Domain always found downstream of DENN domain, found in a variety of signalling proteins; The dDENN domain is part of the tripartite DENN domain. It is always found downstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


:

Pssm-ID: 129037  Cd Length: 69  Bit Score: 76.17  E-value: 5.33e-17
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462625504   323 GDGVARAFLKAQAAFFGSYRNALK---IEPEEPITFCEEAFVSHyRSGAMRQFLQNATQLQLFKQFIDGR 389
Cdd:smart00801    1 NDEIREAFLRFFVNLFGGYRNFLRelrKEPGPVITFDKESFLKS-RPSSERPFLSKFLETQMFSQFIEER 69
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 723-1074 3.44e-11

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 68.04  E-value: 3.44e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462625504  723 DDMAIPSKPPAASPEKPSALLGNSLALPRRPQNRDSilnpsdkeevptPTLGSITIPRPQGRKTPELGIVPPPPIPRPAK 802
Cdd:PHA03247  2620 DTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDD------------PAPGRVSRPRRARRLGRAAQASSPPQRPRRRA 2687

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462625504  803 LQAAGAALGDVSErlqtdrdrraALSPGLLPGVVPQgPTELLQPLSPGPGAAGTSSDALLALLDPLSTAwSGSTLPSRPA 882
Cdd:PHA03247  2688 ARPTVGSLTSLAD----------PPPPPPTPEPAPH-ALVSATPLPPGPAAARQASPALPAAPAPPAVP-AGPATPGGPA 2755

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462625504  883 TPNV-ATPFTPQFSFPPAGTPTPFPQPPLNPFVPSMPAAPPTLPLVSTPAGPfgaPPASLGPAFASGLLLSSAGFCAPHR 961
Cdd:PHA03247  2756 RPARpPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADP---PAAVLAPAAALPPAASPAGPLPPPT 2832

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462625504  962 S-QPNLSALSMPNLFGQMPMGTHTSPLQPL---GPPAVAPSRI--RTLPLARSSARAA--ETKQGLALRPGDPPLLPprp 1033
Cdd:PHA03247  2833 SaQPTAPPPPPGPPPPSLPLGGSVAPGGDVrrrPPSRSPAAKPaaPARPPVRRLARPAvsRSTESFALPPDQPERPP--- 2909

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|.
gi 2462625504 1034 pqgleptlQPSAPQQARDPFEDLLQKTKQDVSPSPALAPAP 1074
Cdd:PHA03247  2910 --------QPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPP 2942
 
Name Accession Description Interval E-value
DENN smart00799
Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The ...
 113-291 1.02e-63

Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The DENN domain is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 214823  Cd Length: 183  Bit Score: 213.60  E-value: 1.02e-63
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462625504   113 SCFCILSYLPWFEVFYKLLNILADYTTKRQENQwNELLETLHKLPIPDPG-----VSVHLSVHSYFTVPDTRELPSIPen 187
Cdd:smart00799    3 KCICILSRLPFFELFRKILNELYRLLPSSSNLP-LELLISLLLYPVPPPGgslvlVSLGPGDLIELQRPLDSSLPLID-- 79

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462625504   188 RNLTEYFVAVDVNNMLHLYASMLYERRILIICSKLSTLTACIHGSAAMLYPMYWQHVYIPVLPPHLLDYCCAPMPYLIGI 267
Cdd:smart00799   80 FSLHELFECLGVENILQLFAALLLERRIIFTSSNLSTLSAVIEALLALLYPFVWQHIYIPILPASLLDVLSAPTPFIIGV 159

                           170       180
                    ....*....|....*....|....
gi 2462625504   268 HLSLMEKVRNMALDDVVILNVDTN 291
Cdd:smart00799  160 HSSYFEEVKELPDEDVVVVDLDTG 183
DENN pfam02141
DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a ...
 114-291 3.28e-44

DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a domain which occurs in several proteins involved in Rab- mediated processes or regulation of MAPK signalling pathways.


Pssm-ID: 460461  Cd Length: 186  Bit Score: 158.51  E-value: 3.28e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462625504  114 CFCILSYLPWFEVFYKLLNILAdytTKRQENQWNELLET-----LHKLPIPDPGVSVHLSVHS-----YFTVPDTRELPS 183
Cdd:pfam02141    5 AYCIISRLPFFNLFKKFLDELY---RRRTISPLPNPIERfianlLYEVPFPPPGRTQKLKPLGgtepiLLQRPEDSELPL 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462625504  184 ipENRNLTEYFVAVDVNNMLHLYASMLYERRILIICSKLSTLTACIHGSAAMLYPMYWQHVYIPVLPPHLLDYCCAPMPY 263
Cdd:pfam02141   82 --EGVDLHLLFRCLSPENILQLFEAALLERRIIFLSSDLARLTLVAEAVVALLYPFVWQHIYIPVLPASLLDVLSAPTPF 159

                          170       180
                   ....*....|....*....|....*...
gi 2462625504  264 LIGIHLSLMEKVRNmALDDVVILNVDTN 291
Cdd:pfam02141  160 IIGVHSRYFDLLED-PLDDVVLVDLDTG 186
uDENN smart00800
Domain always found upstream of DENN domain, found in a variety of signalling proteins; The ...
 48-109 2.56e-19

Domain always found upstream of DENN domain, found in a variety of signalling proteins; The uDENN domain is part of the tripartite DENN domain. It is always found upstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 214824  Cd Length: 89  Bit Score: 83.54  E-value: 2.56e-19
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462625504    48 DPEVQRQFPE-DYSDQEVLQTLTKFCFPFYVD--SLTVSQVGQNFTFVLTDIDSKQRFGFCRLSS 109
Cdd:smart00800   25 KPEILQRYPEkDFEDFPLPDSIPLFCFPEGLDfvTQTSSKDPQFFSFVLTDIDGSRRYGFCLRFY 89
dDENN smart00801
Domain always found downstream of DENN domain, found in a variety of signalling proteins; The ...
 323-389 5.33e-17

Domain always found downstream of DENN domain, found in a variety of signalling proteins; The dDENN domain is part of the tripartite DENN domain. It is always found downstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 129037  Cd Length: 69  Bit Score: 76.17  E-value: 5.33e-17
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462625504   323 GDGVARAFLKAQAAFFGSYRNALK---IEPEEPITFCEEAFVSHyRSGAMRQFLQNATQLQLFKQFIDGR 389
Cdd:smart00801    1 NDEIREAFLRFFVNLFGGYRNFLRelrKEPGPVITFDKESFLKS-RPSSERPFLSKFLETQMFSQFIEER 69
uDENN pfam03456
uDENN domain; This region is always found associated with pfam02141. It is predicted to form ...
 49-107 1.88e-11

uDENN domain; This region is always found associated with pfam02141. It is predicted to form an all beta domain.


Pssm-ID: 460926  Cd Length: 59  Bit Score: 60.32  E-value: 1.88e-11
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462625504   49 PEVQRQFPE-DYSDQEVLQTLTKFCFPFYVDSLtVSQVGQNFTFVLTDIDSKQRFGFCRL 107
Cdd:pfam03456    1 PEVLDRYPEdDWSDPPLPDGIPMFCFPEGLETL-SSREPTFFSFVLTDEDGSRLYGACLT 59
PHA03247 PHA03247
large tegument protein UL36; Provisional
 723-1074 3.44e-11

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 68.04  E-value: 3.44e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462625504  723 DDMAIPSKPPAASPEKPSALLGNSLALPRRPQNRDSilnpsdkeevptPTLGSITIPRPQGRKTPELGIVPPPPIPRPAK 802
Cdd:PHA03247  2620 DTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDD------------PAPGRVSRPRRARRLGRAAQASSPPQRPRRRA 2687

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462625504  803 LQAAGAALGDVSErlqtdrdrraALSPGLLPGVVPQgPTELLQPLSPGPGAAGTSSDALLALLDPLSTAwSGSTLPSRPA 882
Cdd:PHA03247  2688 ARPTVGSLTSLAD----------PPPPPPTPEPAPH-ALVSATPLPPGPAAARQASPALPAAPAPPAVP-AGPATPGGPA 2755

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462625504  883 TPNV-ATPFTPQFSFPPAGTPTPFPQPPLNPFVPSMPAAPPTLPLVSTPAGPfgaPPASLGPAFASGLLLSSAGFCAPHR 961
Cdd:PHA03247  2756 RPARpPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADP---PAAVLAPAAALPPAASPAGPLPPPT 2832

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462625504  962 S-QPNLSALSMPNLFGQMPMGTHTSPLQPL---GPPAVAPSRI--RTLPLARSSARAA--ETKQGLALRPGDPPLLPprp 1033
Cdd:PHA03247  2833 SaQPTAPPPPPGPPPPSLPLGGSVAPGGDVrrrPPSRSPAAKPaaPARPPVRRLARPAvsRSTESFALPPDQPERPP--- 2909

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|.
gi 2462625504 1034 pqgleptlQPSAPQQARDPFEDLLQKTKQDVSPSPALAPAP 1074
Cdd:PHA03247  2910 --------QPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPP 2942
dDENN pfam03455
dDENN domain; This region is always found associated with pfam02141. It is predicted to form a ...
 355-406 1.60e-07

dDENN domain; This region is always found associated with pfam02141. It is predicted to form a globular domain. Although not statistically supported it has been suggested that this domain may be similar to members of the Rho/Rac/Cdc42 GEF family. This N-terminal region of DENN folds into a longin module, consisting of a central antiparallel beta-sheet layered between helix H1 and helices H2 and H3 (strands S1-S5). Rab35 interacts with dDENN via residues in helix 1 and in the loop S3-S4.


Pssm-ID: 460925  Cd Length: 48  Bit Score: 48.73  E-value: 1.60e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 2462625504  355 FCEEAFVSHyRSGAMRQFLQNATQLQLFKQFIDGRLDLLNsgeGFSDVFEEE 406
Cdd:pfam03455    1 FDKEAFLKS-LPSDSRPFLSQFLETQMFNEFIEERLESSD---PSIDLFDEE 48
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 720-1076 1.18e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 43.22  E-value: 1.18e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462625504  720 LGQDDMAIPSKPPAASPEKPSALLGNSLALPRRPqnrdsilnPSDKEEVPTPTLGSITIPRPQGRKTPELGIVPPPPIPR 799
Cdd:pfam03154  167 LQTQPPVLQAQSGAASPPSPPPPGTTQAATAGPT--------PSAPSVPPQGSPATSQPPNQTQSTAAPHTLIQQTPTLH 238

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462625504  800 PAKLQAAGAALGDVSERLQTDRDRRAALSPGLLPGVVPQGPtellQPLSPGPGAAGTSSDALLALLDPLSTAWSGSTLPS 879
Cdd:pfam03154  239 PQRLPSPHPPLQPMTQPPPPSQVSPQPLPQPSLHGQMPPMP----HSLQTGPSHMQHPVPPQPFPLTPQSSQSQVPPGPS 314

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462625504  880 rpatPNVATPFTPQFSFPPAGTPTPFPQPPLNPFVPSMPAAPPTL-PLVSTPAGPFGAPPASLGPAFASGlllsSAGFCA 958
Cdd:pfam03154  315 ----PAAPGQSQQRIHTPPSQSQLQSQQPPREQPLPPAPLSMPHIkPPPTTPIPQLPNPQSHKHPPHLSG----PSPFQM 386

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462625504  959 PHRSQPNLSALSMPNLFGQMPMGTHTSPLQ------PLGPPAVAPSRIRTLPLARSSARAAETKQGLALRPGDPPLLPPR 1032
Cdd:pfam03154  387 NSNLPPPPALKPLSSLSTHHPPSAHPPPLQlmpqsqQLPPPPAQPPVLTQSQSLPPPAASHPPTSGLHQVPSQSPFPQHP 466

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*
gi 2462625504 1033 PPQGLEPT-LQPSAPQQARDPFEDLLQKTKQDVSPSPALAPAPDS 1076
Cdd:pfam03154  467 FVPGGPPPiTPPSGPPTSTSSAMPGIQPPSSASVSSSGPVPAAVS 511
Chi1 COG3469
Chitinase [Carbohydrate transport and metabolism];
833-939 3.33e-03

Chitinase [Carbohydrate transport and metabolism];


Pssm-ID: 442692 [Multi-domain]  Cd Length: 534  Bit Score: 41.28  E-value: 3.33e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462625504  833 PGVVPQGPTELLQPLSPGPGAAGTSSDALLALLDPLSTAWSGSTLPSRPATPNVATPFTPQFSFPPAGTPTPFPQPPLNP 912
Cdd:COG3469    108 GTSTVTTTSTGAGSVTSTTSSTAGSTTTSGASATSSAGSTTTTTTVSGTETATGGTTTTSTTTTTTSASTTPSATTTATA 187

                           90       100
                   ....*....|....*....|....*..
gi 2462625504  913 FVPSMPAAPPTLPLVSTPAGPFGAPPA 939
Cdd:COG3469    188 TTASGATTPSATTTATTTGPPTPGLPK 214
 
Name Accession Description Interval E-value
DENN smart00799
Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The ...
 113-291 1.02e-63

Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The DENN domain is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 214823  Cd Length: 183  Bit Score: 213.60  E-value: 1.02e-63
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462625504   113 SCFCILSYLPWFEVFYKLLNILADYTTKRQENQwNELLETLHKLPIPDPG-----VSVHLSVHSYFTVPDTRELPSIPen 187
Cdd:smart00799    3 KCICILSRLPFFELFRKILNELYRLLPSSSNLP-LELLISLLLYPVPPPGgslvlVSLGPGDLIELQRPLDSSLPLID-- 79

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462625504   188 RNLTEYFVAVDVNNMLHLYASMLYERRILIICSKLSTLTACIHGSAAMLYPMYWQHVYIPVLPPHLLDYCCAPMPYLIGI 267
Cdd:smart00799   80 FSLHELFECLGVENILQLFAALLLERRIIFTSSNLSTLSAVIEALLALLYPFVWQHIYIPILPASLLDVLSAPTPFIIGV 159

                           170       180
                    ....*....|....*....|....
gi 2462625504   268 HLSLMEKVRNMALDDVVILNVDTN 291
Cdd:smart00799  160 HSSYFEEVKELPDEDVVVVDLDTG 183
DENN pfam02141
DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a ...
 114-291 3.28e-44

DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a domain which occurs in several proteins involved in Rab- mediated processes or regulation of MAPK signalling pathways.


Pssm-ID: 460461  Cd Length: 186  Bit Score: 158.51  E-value: 3.28e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462625504  114 CFCILSYLPWFEVFYKLLNILAdytTKRQENQWNELLET-----LHKLPIPDPGVSVHLSVHS-----YFTVPDTRELPS 183
Cdd:pfam02141    5 AYCIISRLPFFNLFKKFLDELY---RRRTISPLPNPIERfianlLYEVPFPPPGRTQKLKPLGgtepiLLQRPEDSELPL 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462625504  184 ipENRNLTEYFVAVDVNNMLHLYASMLYERRILIICSKLSTLTACIHGSAAMLYPMYWQHVYIPVLPPHLLDYCCAPMPY 263
Cdd:pfam02141   82 --EGVDLHLLFRCLSPENILQLFEAALLERRIIFLSSDLARLTLVAEAVVALLYPFVWQHIYIPVLPASLLDVLSAPTPF 159

                          170       180
                   ....*....|....*....|....*...
gi 2462625504  264 LIGIHLSLMEKVRNmALDDVVILNVDTN 291
Cdd:pfam02141  160 IIGVHSRYFDLLED-PLDDVVLVDLDTG 186
uDENN smart00800
Domain always found upstream of DENN domain, found in a variety of signalling proteins; The ...
 48-109 2.56e-19

Domain always found upstream of DENN domain, found in a variety of signalling proteins; The uDENN domain is part of the tripartite DENN domain. It is always found upstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 214824  Cd Length: 89  Bit Score: 83.54  E-value: 2.56e-19
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462625504    48 DPEVQRQFPE-DYSDQEVLQTLTKFCFPFYVD--SLTVSQVGQNFTFVLTDIDSKQRFGFCRLSS 109
Cdd:smart00800   25 KPEILQRYPEkDFEDFPLPDSIPLFCFPEGLDfvTQTSSKDPQFFSFVLTDIDGSRRYGFCLRFY 89
dDENN smart00801
Domain always found downstream of DENN domain, found in a variety of signalling proteins; The ...
 323-389 5.33e-17

Domain always found downstream of DENN domain, found in a variety of signalling proteins; The dDENN domain is part of the tripartite DENN domain. It is always found downstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 129037  Cd Length: 69  Bit Score: 76.17  E-value: 5.33e-17
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462625504   323 GDGVARAFLKAQAAFFGSYRNALK---IEPEEPITFCEEAFVSHyRSGAMRQFLQNATQLQLFKQFIDGR 389
Cdd:smart00801    1 NDEIREAFLRFFVNLFGGYRNFLRelrKEPGPVITFDKESFLKS-RPSSERPFLSKFLETQMFSQFIEER 69
uDENN pfam03456
uDENN domain; This region is always found associated with pfam02141. It is predicted to form ...
 49-107 1.88e-11

uDENN domain; This region is always found associated with pfam02141. It is predicted to form an all beta domain.


Pssm-ID: 460926  Cd Length: 59  Bit Score: 60.32  E-value: 1.88e-11
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462625504   49 PEVQRQFPE-DYSDQEVLQTLTKFCFPFYVDSLtVSQVGQNFTFVLTDIDSKQRFGFCRL 107
Cdd:pfam03456    1 PEVLDRYPEdDWSDPPLPDGIPMFCFPEGLETL-SSREPTFFSFVLTDEDGSRLYGACLT 59
PHA03247 PHA03247
large tegument protein UL36; Provisional
 723-1074 3.44e-11

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 68.04  E-value: 3.44e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462625504  723 DDMAIPSKPPAASPEKPSALLGNSLALPRRPQNRDSilnpsdkeevptPTLGSITIPRPQGRKTPELGIVPPPPIPRPAK 802
Cdd:PHA03247  2620 DTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDD------------PAPGRVSRPRRARRLGRAAQASSPPQRPRRRA 2687

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462625504  803 LQAAGAALGDVSErlqtdrdrraALSPGLLPGVVPQgPTELLQPLSPGPGAAGTSSDALLALLDPLSTAwSGSTLPSRPA 882
Cdd:PHA03247  2688 ARPTVGSLTSLAD----------PPPPPPTPEPAPH-ALVSATPLPPGPAAARQASPALPAAPAPPAVP-AGPATPGGPA 2755

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462625504  883 TPNV-ATPFTPQFSFPPAGTPTPFPQPPLNPFVPSMPAAPPTLPLVSTPAGPfgaPPASLGPAFASGLLLSSAGFCAPHR 961
Cdd:PHA03247  2756 RPARpPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADP---PAAVLAPAAALPPAASPAGPLPPPT 2832

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462625504  962 S-QPNLSALSMPNLFGQMPMGTHTSPLQPL---GPPAVAPSRI--RTLPLARSSARAA--ETKQGLALRPGDPPLLPprp 1033
Cdd:PHA03247  2833 SaQPTAPPPPPGPPPPSLPLGGSVAPGGDVrrrPPSRSPAAKPaaPARPPVRRLARPAvsRSTESFALPPDQPERPP--- 2909

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|.
gi 2462625504 1034 pqgleptlQPSAPQQARDPFEDLLQKTKQDVSPSPALAPAP 1074
Cdd:PHA03247  2910 --------QPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPP 2942
dDENN pfam03455
dDENN domain; This region is always found associated with pfam02141. It is predicted to form a ...
 355-406 1.60e-07

dDENN domain; This region is always found associated with pfam02141. It is predicted to form a globular domain. Although not statistically supported it has been suggested that this domain may be similar to members of the Rho/Rac/Cdc42 GEF family. This N-terminal region of DENN folds into a longin module, consisting of a central antiparallel beta-sheet layered between helix H1 and helices H2 and H3 (strands S1-S5). Rab35 interacts with dDENN via residues in helix 1 and in the loop S3-S4.


Pssm-ID: 460925  Cd Length: 48  Bit Score: 48.73  E-value: 1.60e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 2462625504  355 FCEEAFVSHyRSGAMRQFLQNATQLQLFKQFIDGRLDLLNsgeGFSDVFEEE 406
Cdd:pfam03455    1 FDKEAFLKS-LPSDSRPFLSQFLETQMFNEFIEERLESSD---PSIDLFDEE 48
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
873-1074 9.53e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 46.41  E-value: 9.53e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462625504  873 SGSTLPSRPATPNVATPfTPQFSFPPAGTPTPfpqpplnpfvPSMPAAPPTLPLVSTPAGPFGAPPASLGPAFASGLLLS 952
Cdd:PRK12323   369 GGGAGPATAAAAPVAQP-APAAAAPAAAAPAP----------AAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAAR 437

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462625504  953 SAGFCAP-HRSQPNLSALSMPnlfgqmPMGTHTSPLQPLGPPAVAPSRIRTLPLARSSARAA------ETKQGLALRPGD 1025
Cdd:PRK12323   438 QASARGPgGAPAPAPAPAAAP------AAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADddpppwEELPPEFASPAP 511

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*....
gi 2462625504 1026 PPLLPPRPPQGLEPTLQPsAPQQARDPFEDLLQKTKQDVSPSPALAPAP 1074
Cdd:PRK12323   512 AQPDAAPAGWVAESIPDP-ATADPDDAFETLAPAPAAAPAPRAAAATEP 559
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 575-961 7.40e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 43.62  E-value: 7.40e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462625504  575 SEDSSDDECQREEGPSSGFTESfffSAPFEWPQPYRTLRESDSAEGDEAESPEQQVRKSTGPVPAPPDRAASI-DLLEDV 653
Cdd:PHA03307    58 GAAACDRFEPPTGPPPGPGTEA---PANESRSTPTWSLSTLAPASPAREGSPTPPGPSSPDPPPPTPPPASPPpSPAPDL 134

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462625504  654 FSNLDMEAALQPLGQAKSLEDLRAPKDLREQPGTFDYQRLDLGGSERSRGVTVALKLTHPYNKLWSLGQDDMAIPSKPPA 733
Cdd:PHA03307   135 SEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAALPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRSSPIS 214

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462625504  734 ASPEKPSALLGNSLALPRRPQNRDSILNPS------DKEEVPTPTLGSITIPRPQGRKTPelgivppppiprpAKLQAAG 807
Cdd:PHA03307   215 ASASSPAPAPGRSAADDAGASSSDSSSSESsgcgwgPENECPLPRPAPITLPTRIWEASG-------------WNGPSSR 281

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462625504  808 AalGDVSERlQTDRDRRAALSPG--LLPGVVPQGPTELLQPLSPGPGAAGTSSDALLALLDPLSTAWSGSTLPSRPATPN 885
Cdd:PHA03307   282 P--GPASSS-SSPRERSPSPSPSspGSGPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSRSPSPSRPPP 358

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462625504  886 VATPFTPQFSFPPAGTPTPFPQPPLNPFVPSMPAAPPTLPLVSTPAGPFGAPPASLGPAFASGlllSSAGFCAPHR 961
Cdd:PHA03307   359 PADPSSPRKRPRPSRAPSSPAASAGRPTRRRARAAVAGRARRRDATGRFPAGRPRPSPLDAGA---ASGAFYARYP 431
PHA03247 PHA03247
large tegument protein UL36; Provisional
 728-946 1.06e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.39  E-value: 1.06e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462625504  728 PSKPPAASPEKPSALLGNSLALPRRPQNRDSILNPSDKEE-VPTPTLGsitiPRPQGRKTPELGIVPPPPIPRPAKLQAA 806
Cdd:PHA03247  2867 PSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPErPPQPQAP----PPPQPQPQPPPPPQPQPPPPPPPRPQPP 2942

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462625504  807 GAALGDVSERLQTDRDRRAALSPGLLPGVVPQGPTELLQPLSPGPGAAGTSSDALLALLDPLSTAWSGSTLPSRPATPNV 886
Cdd:PHA03247  2943 LAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASSTPPLTGHSLSRVSSWASSLALHEETDPPPV 3022

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462625504  887 A---TPFTPQ-----------FSFPP---AGTPTPFPQPPLNPFVPSMPAAPPTLPLVSTPAGPFGAPPASLGPAFA 946
Cdd:PHA03247  3023 SlkqTLWPPDdtedsdadslfDSDSErsdLEALDPLPPEPHDPFAHEPDPATPEAGARESPSSQFGPPPLSANAALS 3099
PHA03247 PHA03247
large tegument protein UL36; Provisional
 726-1013 1.15e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.39  E-value: 1.15e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462625504  726 AIPSKPPAASPEKPSAL-LGNSLA----LPRRPQNRDSILNPSDKEEVPTPTLgsitiPRPQGRKTPElgivppppiprp 800
Cdd:PHA03247  2834 AQPTAPPPPPGPPPPSLpLGGSVApggdVRRRPPSRSPAAKPAAPARPPVRRL-----ARPAVSRSTE------------ 2896

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462625504  801 aklqaAGAALGDVSERLQTDRDRRAALSPGLLPGVVPQGPTELLQPLSPGPGAAGTSSDALLALLDPLSTAWSGSTLPSR 880
Cdd:PHA03247  2897 -----SFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGR 2971

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462625504  881 PATPNVATPFtpqfSFPPAGTPTPFPQPPLNPFVPSMPAAPPTLPL-VSTPAGPFGA-----PPASLGPAFASGLLLSSA 954
Cdd:PHA03247  2972 VAVPRFRVPQ----PAPSREAPASSTPPLTGHSLSRVSSWASSLALhEETDPPPVSLkqtlwPPDDTEDSDADSLFDSDS 3047

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462625504  955 GFCAPHRSQPN----LSALSMPNLFGQMPMGTHTSPLQPLGPPAVAPSRIRTLPLARSSARAA 1013
Cdd:PHA03247  3048 ERSDLEALDPLppepHDPFAHEPDPATPEAGARESPSSQFGPPPLSANAALSRRYVRSTGRSA 3110
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 720-1076 1.18e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 43.22  E-value: 1.18e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462625504  720 LGQDDMAIPSKPPAASPEKPSALLGNSLALPRRPqnrdsilnPSDKEEVPTPTLGSITIPRPQGRKTPELGIVPPPPIPR 799
Cdd:pfam03154  167 LQTQPPVLQAQSGAASPPSPPPPGTTQAATAGPT--------PSAPSVPPQGSPATSQPPNQTQSTAAPHTLIQQTPTLH 238

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462625504  800 PAKLQAAGAALGDVSERLQTDRDRRAALSPGLLPGVVPQGPtellQPLSPGPGAAGTSSDALLALLDPLSTAWSGSTLPS 879
Cdd:pfam03154  239 PQRLPSPHPPLQPMTQPPPPSQVSPQPLPQPSLHGQMPPMP----HSLQTGPSHMQHPVPPQPFPLTPQSSQSQVPPGPS 314

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462625504  880 rpatPNVATPFTPQFSFPPAGTPTPFPQPPLNPFVPSMPAAPPTL-PLVSTPAGPFGAPPASLGPAFASGlllsSAGFCA 958
Cdd:pfam03154  315 ----PAAPGQSQQRIHTPPSQSQLQSQQPPREQPLPPAPLSMPHIkPPPTTPIPQLPNPQSHKHPPHLSG----PSPFQM 386

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462625504  959 PHRSQPNLSALSMPNLFGQMPMGTHTSPLQ------PLGPPAVAPSRIRTLPLARSSARAAETKQGLALRPGDPPLLPPR 1032
Cdd:pfam03154  387 NSNLPPPPALKPLSSLSTHHPPSAHPPPLQlmpqsqQLPPPPAQPPVLTQSQSLPPPAASHPPTSGLHQVPSQSPFPQHP 466

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*
gi 2462625504 1033 PPQGLEPT-LQPSAPQQARDPFEDLLQKTKQDVSPSPALAPAPDS 1076
Cdd:pfam03154  467 FVPGGPPPiTPPSGPPTSTSSAMPGIQPPSSASVSSSGPVPAAVS 511
PHA03247 PHA03247
large tegument protein UL36; Provisional
 518-1013 1.30e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.00  E-value: 1.30e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462625504  518 LRPTRPPPkiqrSRPVRPPRPHVVKRPkSNIAVEGRRTSVPSPEHLVKPLrhyavfLSEDSSDDEcqREEGPSSGFTESf 597
Cdd:PHA03247  2555 LPPAAPPA----APDRSVPPPRPAPRP-SEPAVTSRARRPDAPPQSARPR------APVDDRGDP--RGPAPPSPLPPD- 2620

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462625504  598 ffSAPFEWPQPYRTLRESDSAEGDEAESP--EQQVRKSTGPVPAPPDRAASIDLLEDVFSNLD---MEAALQPLGQAKSL 672
Cdd:PHA03247  2621 --THAPDPPPPSPSPAANEPDPHPPPTVPppERPRDDPAPGRVSRPRRARRLGRAAQASSPPQrprRRAARPTVGSLTSL 2698

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462625504  673 EDLRAPKDLREqpgtfdyqrldlggsERSRGVTVALKLTHPYNklwSLGQDDMAIPSKP-PAASPEKPSALLGnslalPR 751
Cdd:PHA03247  2699 ADPPPPPPTPE---------------PAPHALVSATPLPPGPA---AARQASPALPAAPaPPAVPAGPATPGG-----PA 2755

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462625504  752 RPQNRDSILNPsdkeevPTPTLGSITIPRPQGRKTPelgivppppiprpaklqAAGAALGDVSERLQTDRDRRAALSPGL 831
Cdd:PHA03247  2756 RPARPPTTAGP------PAPAPPAAPAAGPPRRLTR-----------------PAVASLSESRESLPSPWDPADPPAAVL 2812

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462625504  832 LPGVVpQGPTELLQPLSPGPGAAGTSSDALLALLDPLSTAWSGSTLP---------SRPATPNVATPFTPQFSF----PP 898
Cdd:PHA03247  2813 APAAA-LPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPggdvrrrppSRSPAAKPAAPARPPVRRlarpAV 2891

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462625504  899 AGTPTPFPQPPLNPFVPSMPAAP------PTLPLVSTPAGPFGAPPASLGPAfASGLLLSSAGFCAPHRSQPNLSALSMP 972
Cdd:PHA03247  2892 SRSTESFALPPDQPERPPQPQAPpppqpqPQPPPPPQPQPPPPPPPRPQPPL-APTTDPAGAGEPSGAVPQPWLGALVPG 2970

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|.
gi 2462625504  973 NLfgQMPMGTHTSPLQPLGPPAVAPSRIRTLPLARSSARAA 1013
Cdd:PHA03247  2971 RV--AVPRFRVPQPAPSREAPASSTPPLTGHSLSRVSSWAS 3009
PHA03378 PHA03378
EBNA-3B; Provisional
 602-1016 3.32e-03

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 41.59  E-value: 3.32e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462625504  602 PFEWPQPYRTLRESDSAEGDEA------------ESPEQQVRKSTGPvPAPPD----RAASIDLLEDVFSNLDMEAALQP 665
Cdd:PHA03378   480 PLPHPQVTPVILHQPPAQGVQAhgsmldllekddEDMEQRVMATLLP-PSPPQpragRRAPCVYTEDLDIESDEPASTEP 558

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462625504  666 LgqAKSLEDLRAPKDLREQPGTFDYQRlDLGGSERSRGVTVALKlTHPynklwSLGQDDMAIPSKPPAASpeKPSALLGN 745
Cdd:PHA03378   559 V--HDQLLPAPGLGPLQIQPLTSPTTS-QLASSAPSYAQTPWPV-PHP-----SQTPEPPTTQSHIPETS--APRQWPMP 627

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462625504  746 SLALPRRPQNRDSI-LNPSDKEEVPTPTLGSITIPRPQGRKTPELGIVPPPPIPRPAKLQAAGAALGDVSERLQTdRDRR 824
Cdd:PHA03378   628 LRPIPMRPLRMQPItFNVLVFPTPHQPPQVEITPYKPTWTQIGHIPYQPSPTGANTMLPIQWAPGTMQPPPRAPT-PMRP 706

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462625504  825 AALSPGllPGVVPQGPTELLQPLSPGPGAAGTSSDALLALLDPLSTAWSGSTLPSRP--ATPNVATPFTPQFSFPPAGTP 902
Cdd:PHA03378   707 PAAPPG--RAQRPAAATGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPgrARPPAAAPGAPTPQPPPQAPP 784

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462625504  903 TPFPQPPLNPFVPSMPAAPPTLPLVSTPagpfgAPPASLGPAFASGLLLSSAGFCAPHRSQPNLSALSMPNLFGQMP--- 979
Cdd:PHA03378   785 APQQRPRGAPTPQPPPQAGPTSMQLMPR-----AAPGQQGPTKQILRQLLTGGVKRGRPSLKKPAALERQAAAGPTPspg 859

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|....
gi 2462625504  980 --MGTHTSPLQPLGPPAVAPSRI-----RTLPLARSSARAAETK 1016
Cdd:PHA03378   860 sgTSDKIVQAPVFYPPVLQPIQVmrqlgSVRAAAASTVTQAPTE 903
Chi1 COG3469
Chitinase [Carbohydrate transport and metabolism];
833-939 3.33e-03

Chitinase [Carbohydrate transport and metabolism];


Pssm-ID: 442692 [Multi-domain]  Cd Length: 534  Bit Score: 41.28  E-value: 3.33e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462625504  833 PGVVPQGPTELLQPLSPGPGAAGTSSDALLALLDPLSTAWSGSTLPSRPATPNVATPFTPQFSFPPAGTPTPFPQPPLNP 912
Cdd:COG3469    108 GTSTVTTTSTGAGSVTSTTSSTAGSTTTSGASATSSAGSTTTTTTVSGTETATGGTTTTSTTTTTTSASTTPSATTTATA 187

                           90       100
                   ....*....|....*....|....*..
gi 2462625504  913 FVPSMPAAPPTLPLVSTPAGPFGAPPA 939
Cdd:COG3469    188 TTASGATTPSATTTATTTGPPTPGLPK 214
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 726-1081 5.27e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 40.74  E-value: 5.27e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462625504  726 AIPSKPPAASPEKPSALLGNSLALPRRPQNRDSilNPSDKEEVPTPTLGSITIPRPQGRKTPELGIVPPPPIPRPAKLQA 805
Cdd:PRK07764   427 AAPQPAPAPAPAPAPPSPAGNAPAGGAPSPPPA--AAPSAQPAPAPAAAPEPTAAPAPAPPAAPAPAAAPAAPAAPAAPA 504

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462625504  806 AGAALGDVSER----LQTDRDRRAALSPGLLPGVV---PQGPTELLQPLSPGPGAA------------------------ 854
Cdd:PRK07764   505 GADDAATLRERwpeiLAAVPKRSRKTWAILLPEATvlgVRGDTLVLGFSTGGLARRfaspgnaevlvtalaeelggdwqv 584

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462625504  855 ----GTSSDALLALLDPLSTAWSGSTLPSRPATPnvATPFTPQFSFPPAGTPTPFPQPPLNPFVPSMPAAPPTLPLVSTP 930
Cdd:PRK07764   585 eavvGPAPGAAGGEGPPAPASSGPPEEAARPAAP--AAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDA 662

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462625504  931 AGPFGAPPASLGPAFASglllssagfcaphrsqpnlsalsmpnlfGQMPMGTHTSPLQPLG--PPAVAPSRIRTLPLARS 1008
Cdd:PRK07764   663 SDGGDGWPAKAGGAAPA----------------------------APPPAPAPAAPAAPAGaaPAQPAPAPAATPPAGQA 714

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462625504 1009 SARAAETKQGLALRPGDPPLLPPRPPQGLEPTLQPSAPQQARDPFEDLLQKTKQDVSPSPALAPAPDSVEQLR 1081
Cdd:PRK07764   715 DDPAAQPPQAAQGASAPSPAADDPVPLPPEPDDPPDPAGAPAQPPPPPAPAPAAAPAAAPPPSPPSEEEEMAE 787
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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